{"id":8050,"date":"2022-08-16T05:47:00","date_gmt":"2022-08-15T21:47:00","guid":{"rendered":"https:\/\/www.franchise.com.hk\/sirnaomics%e7%a0%94%e7%99%bc%e7%94%a8%e6%96%bc%e5%84%aa%e5%8c%96galnac%e9%81%9e%e9%80%81%e5%b9%b3%e5%8f%b0%e7%9a%84%e8%82%bd%e5%b0%8d%e6%8e%a5%e8%bc%89%e9%ab%94%ef%bc%88pdovtm%ef%bc%89%ef%bc%8c\/8050"},"modified":"2022-08-16T05:47:00","modified_gmt":"2022-08-15T21:47:00","slug":"sirnaomics%e7%a0%94%e7%99%bc%e7%94%a8%e6%96%bc%e5%84%aa%e5%8c%96galnac%e9%81%9e%e9%80%81%e5%b9%b3%e5%8f%b0%e7%9a%84%e8%82%bd%e5%b0%8d%e6%8e%a5%e8%bc%89%e9%ab%94%ef%bc%88pdovtm%ef%bc%89%ef%bc%8c","status":"publish","type":"post","link":"https:\/\/www.franchise.com.hk\/zh-hans\/sirnaomics%e7%a0%94%e7%99%bc%e7%94%a8%e6%96%bc%e5%84%aa%e5%8c%96galnac%e9%81%9e%e9%80%81%e5%b9%b3%e5%8f%b0%e7%9a%84%e8%82%bd%e5%b0%8d%e6%8e%a5%e8%bc%89%e9%ab%94%ef%bc%88pdovtm%ef%bc%89%ef%bc%8c\/8050","title":{"rendered":"Sirnaomics\u7814\u767c\u7528\u65bc\u512a\u5316GalNAc\u905e\u9001\u5e73\u53f0\u7684\u80bd\u5c0d\u63a5\u8f09\u9ad4\uff08PDoV(TM)\uff09\uff0c\u81f4\u529b\u65bc\u5275\u65b0siRNA\u7642\u6cd5"},"content":{"rendered":"

\u4e00\u7a2e\u5c08\u6709\u7684GalNAc\u905e\u9001\u7cfb\u7d71\uff0c\u5177\u5099\u5f37\u5316\u7684\u5167\u6db5\u9ad4\u9003\u9038\u6027\u548c\u96d9\u9776\u5411\u6027<\/p>\n

\u7f8e\u570b\u99ac\u91cc\u862d\u5dde\u84cb\u745f\u65af\u5821\u5e02\u548c\u4e2d\u570b\u8607\u5dde<\/span>2022\u5e748\u670816\u65e5<\/span> \/\u7f8e\u901a\u793e\/ —\u00a0Sirnaomics Ltd.\uff08\u300c\u516c\u53f8\u300d\uff0c\u300cSirnaomics\u300d\uff0c\u80a1\u4efd\u4ee3\u865f\uff1a2257.HK\uff09\uff0c\u662f\u4e00\u5bb6\u884c\u696d\u9818\u5148\u7684\u5c08\u6ce8\u65bc\u63a2\u7d22\u53ca\u958b\u767cRNAi\u7642\u6cd5\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\u3002Sirnaomics\u5ba3\u4f48\u516c\u53f8\u5df2\u6210\u529f\u7814\u767c\u80bd\u5c0d\u63a5\u8f09\u9ad4\uff08PDoV\u2122\uff09\uff0c\u9032\u4e00\u6b65\u512a\u5316\u516c\u53f8siRNA\u85e5\u7269\u905e\u9001\u7684\u591a\u80bdGalNAc\u5e73\u53f0\u3002<\/p>\n

Sirnaomics\u7684GalNAc\u905e\u9001\u5e73\u53f0\u5229\u7528\u4e86PDoV\u2122\u8a2d\u8a08\u4e2d\u6240\u9078\u5b9a\u7684\u5c0f\u80bd\u4e4b\u512a\u52e2\uff0c\u8a72\u985e\u5c0f\u80bd\u4e0d\u4f46\u5177\u6709\u6d3b\u8e8d\u7684\u5167\u6db5\u9ad4\u9003\u9038\u6027\uff0c\u4e14\u70ba\u96d9siRNA\u6291\u5236\u5291\u5076\u806f\u63d0\u4f9b\u4e86\u5169\u500b\u7d50\u5408\u4f4d\u9ede\u3002\u5728\u7d30\u80de\u57f9\u990a\u548c\u52d5\u7269\u6a21\u578b\u4e2d\uff0c\u5f97\u76ca\u65bcPDoV\u6240\u5177\u5099\u7684\u5feb\u901f\u5167\u6db5\u9ad4\u9003\u9038\u7684\u7279\u6027\uff0c\u76f8\u8f03\u55ae\u7368\u4f7f\u7528GalNAc\u5e73\u53f0\uff0cPDoV-GalNAc\u5e73\u53f0\u53ef\u66f4\u5feb\u5730\u5be6\u73fe\u5c0d\u65bc\u9776\u5411\u57fa\u56e0\u7684\u6572\u4f4e\u3002\u5728\u4e0a\u8ff0\u7814\u7a76\u7684\u7b2c\u4e00\u5468PDoV-GalNAc\u5e73\u53f0\u5df2\u5be6\u73fe\u9776\u5411\u57fa\u56e0\u7684\u6700\u5927\u6572\u4f4e\uff0c\u800c\u55ae\u7368\u4f7f\u7528GalNAc\u5e73\u53f0\u5247\u9700\u8981\u5230\u7b2c\u4e09\u5468\u65b9\u53ef\u9054\u6210\u3002<\/p>\n

PDoV-GalNAc\u905e\u9001\u6280\u8853\u53ef\u4ee5\u6709\u6548\u5730\u9069\u7528\u65bc\u5177\u6709\u4e0d\u540csiRNA\u7684\u96d9\u9776\u5411siRNA\u7642\u6cd5\uff0c\u540c\u6642\u4ea6\u80fd\u91dd\u5c0d\u540c\u4e00mRNA\u7684\u5169\u500b\u5340\u57df\u6216\uff08\u5169\u500b\u85e5\u7269\u9776\u9ede\u4e2d\uff09\u4e0d\u540cmRNA\u3002\u96d9\u9776\u9edePDoV-GalNAc siRNA\u8a2d\u8a08\u5df2\u8b49\u660e\uff0c\u76f8\u6bd4\u8d77\u55ae\u4e00\u7684siRNA\u8a2d\u8a08\uff0c\u5176\u5728\u9ad4\u5916\u5c07\u9776\u5411\u57fa\u56e0\u6572\u4f4e\u7684\u6548\u7387\u9ad810\u81f315\u500d\u3002\u76ee\u524dSirnaomics\u6b63\u5728\u5229\u7528\u8a72\u6280\u8853\u958b\u767c\u591a\u6b3e\u65b0\u578b\u7684siRNA\u5019\u9078\u85e5\u7269\uff0c\u5305\u62ec\u7528\u65bc\u6cbb\u7642\u8840\u9ad8\u7518\u6cb9\u4e09\u916f\u5347\u9ad8\u9776\u5411\u809d\u7d30\u80de\u8868\u9054\u7684PCSK9\u57fa\u56e0\u7684STP135G\u3001\u9776\u5411\u4e59\u578b\u809d\u708e\u75c5\u6bd2mRNA\u7684STP145G\u4ee5\u53ca\u7528\u65bc\u6cbb\u7642\u9ad8\u8840\u58d3\u9776\u5411\u809d\u7d30\u80de\u8868\u9054\u7684\u8840\u7ba1\u7dca\u5f35\u7d20\u539f\u7684STP165G\u3002<\/p>\n

Sirnaomics\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u6703\u4e3b\u5e2d\u3001\u57f7\u884c\u8463\u4e8b\u3001\u7e3d\u88c1\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u9678\u967d\u535a\u58eb\u8868\u793a\uff1a\u300cSirnaomics\u5c0dGalNAc\u905e\u9001\u5e73\u53f0\u9032\u884c\u4e86\u5927\u91cf\u6295\u8cc7\uff0c\u56e0\u70ba\u8207\u76ee\u524d\u7528\u65bc\u81e8\u5e8a\u958b\u767c\u7684\u5176\u4ed6\u905e\u9001\u5e73\u53f0\u76f8\u6bd4\uff0cGalNAc\u905e\u9001\u5e73\u53f0\u5305\u542b\u4e86\u66f4\u70ba\u7368\u7279\u7684\u8a2d\u8a08\u8207\u5275\u65b0\u6280\u8853\u3002\u96a8\u8457\u6211\u5011\u5229\u7528PDoV-GalNAc\u548cGalAhead\u2122\u905e\u9001\u5e73\u53f0\u7814\u767c\u7684siRNA\u5019\u9078\u7522\u54c1\u9032\u5165\u81e8\u5e8a\u968e\u6bb5\uff0cSirnaomics\u6b63\u5728\u958b\u767c\u8207\u809d\u7d30\u80de\u76f8\u95dc\u75be\u75c5\u7684\u5275\u65b0\u7642\u6cd5\u3002\u6211\u5011\u7684GalNAc\u548c\u591a\u80bd\u7d0d\u7c73\u7c92\u5b50\uff08PNP\uff09\u905e\u9001\u6280\u8853\u70ba\u89e3\u6c7a\u5ee3\u6cdb\u672a\u6eff\u8db3\u7684\u91ab\u7642\u9700\u6c42\u5960\u5b9a\u4e86\u5805\u5be6\u7684\u57fa\u790e\u3002\u300d<\/p>\n

\u300c\u6211\u5011\u7684\u9ad4\u5916\u53ca\u9ad4\u5167\u7684\u6578\u64da\u5df2\u7d93\u8b49\u5be6\uff0c\u91dd\u5c0d\u901a\u904eGalNAc\u905e\u9001\u5e73\u53f0\u7814\u767c\u7684\u6cbb\u7642\u65b9\u6cd5\uff0c\u6211\u5011\u7684PDoV\u8a2d\u8a08\u5177\u6709\u89e3\u6c7a\u5167\u6db5\u9ad4\u9003\u9038\u65b9\u9762\u6311\u6230\u7684\u50f9\u503c\u3002\u300dSirnaomics\u57f7\u884c\u8463\u4e8b\u517c\u9996\u5e2d\u79d1\u5b78\u5b98David Evans\u535a\u58eb\u8aaa\u9053\uff0c\u300cPDoV-GalNAc\u905e\u9001\u5e73\u53f0\u4e0d\u50c5\u589e\u5f37\u4e86\u55ae\u4e00siRNA\u7642\u6cd5\u7684\u512a\u52e2\uff0c\u800c\u4e14\u9084\u9032\u4e00\u6b65\u589e\u52a0\u4e86\u96d9\u9776\u5411siRNA\u5019\u9078\u85e5\u7269\u7684\u7642\u6548\u3002Sirnaomics\u7684\u79d1\u5b78\u5718\u968a\u5c07\u901a\u904e\u958b\u767c\u9019\u985e\u5c16\u7aef\u6280\u8853\u4ee5\u7e7c\u7e8c\u63a8\u9032\u6211\u5011\u7684\u5275\u65b0RNAi\u7642\u6cd5\u3002\u300d<\/p>\n

\u95dc\u65bcSirnaomics<\/p>\n

Sirnaomics\u662f\u4e00\u5bb6RNA\u7642\u6cd5\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u516c\u53f8\u5019\u9078\u7522\u54c1\u8655\u65bc\u81e8\u5e8a\u524d\u53ca\u81e8\u5e8a\u968e\u6bb5\uff0c\u5c08\u6ce8\u65bc\u63a2\u7d22\u53ca\u958b\u767c\u5275\u65b0\u85e5\u7269\uff0c\u7528\u65bc\u6cbb\u7642\u5b58\u5728\u91ab\u7642\u9700\u6c42\u53ca\u9f90\u5927\u5e02\u5834\u6a5f\u6703\u7684\u9069\u61c9\u75c7\u3002Sirnaomics\u662f\u5728\u4e2d\u570b\u548c\u7f8e\u570b\u5747\u64c1\u6709\u91cd\u8981\u5e02\u5834\u5730\u4f4d\u7684\u9996\u5bb6\u81e8\u5e8a\u968e\u6bb5RNA\u7642\u6cd5\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u4e14\u662f\u9996\u5bb6\u5c07\u5176\u6838\u5fc3\u7522\u54c1STP705\u7684RNAi\u7642\u6cd5\u5728\u816b\u7624\u5b78\u9818\u57df\u53d6\u5f97\u7a4d\u6975IIa\u671f\u81e8\u5e8a\u7d50\u679c\u7684\u516c\u53f8\u3002\u5982\u6b32\u4e86\u89e3\u66f4\u591a\u95dc\u65bc\u516c\u53f8\u8cc7\u8a0a\uff0c\u53ef\u700f\u89bd\uff1awww.sirnaomics.com<\/a>\u3002<\/p>\n

\u806f\u7e6b\u65b9\u5f0f\uff1a
David M. Evans\u535a\u58eb
Sirnaomics\u57f7\u884c\u8463\u4e8b\u517c\u9996\u5e2d\u79d1\u5b78\u5b98
\u96fb\u90f5\uff1aDavidEvans@sirnaomics.com<\/a><\/p>\n

\u6295\u8cc7\u8005\u95dc\u4fc2\uff1a
\u8449\u6c38\u57fa
Sirnaomics\u4e2d\u570b\u5340\u9996\u5e2d\u8ca1\u52d9\u5b98
\u96fb\u90f5\uff1aNigelYip@sirnaomics.com<\/a><\/p>\n

\u7f8e\u570b\u50b3\u5a92\u67e5\u8a62\uff1a
Alexis Feinberg<\/span>
\u96fb\u8a71\uff1a+1 203 939 2225
\u96fb\u90f5\uff1aAlexis.Feinberg@westwicke.com<\/a><\/p>\n

\u4e9e\u6d32\u50b3\u5a92\u67e5\u8a62\uff1a
\u674e\u8000\u69ae
\u96fb\u8a71\uff1a+852 3150 6707
\u96fb\u90f5\uff1asirnaomics.hk@pordahavas.com<\/a><\/p>\n

\u00a0<\/p>","protected":false},"excerpt":{"rendered":"

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