{"id":7636,"date":"2022-07-19T00:00:00","date_gmt":"2022-07-18T16:00:00","guid":{"rendered":"https:\/\/www.franchise.com.hk\/%e9%99%8d%e7%b3%96%e5%92%8c%e6%b8%9b%e9%87%8d%e7%99%82%e6%95%88%e9%a1%af%e8%91%97%ef%bc%9a%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%ae%a3%e4%bd%88mazdutideibi362-%e5%9c%a8%e4%b8%ad%e5%9c%8b2%e5%9e%8b\/7636"},"modified":"2022-07-19T00:00:00","modified_gmt":"2022-07-18T16:00:00","slug":"%e9%99%8d%e7%b3%96%e5%92%8c%e6%b8%9b%e9%87%8d%e7%99%82%e6%95%88%e9%a1%af%e8%91%97%ef%bc%9a%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%ae%a3%e4%bd%88mazdutideibi362-%e5%9c%a8%e4%b8%ad%e5%9c%8b2%e5%9e%8b","status":"publish","type":"post","link":"https:\/\/www.franchise.com.hk\/zh-hans\/%e9%99%8d%e7%b3%96%e5%92%8c%e6%b8%9b%e9%87%8d%e7%99%82%e6%95%88%e9%a1%af%e8%91%97%ef%bc%9a%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%ae%a3%e4%bd%88mazdutideibi362-%e5%9c%a8%e4%b8%ad%e5%9c%8b2%e5%9e%8b\/7636","title":{"rendered":"\u964d\u7cd6\u548c\u6e1b\u91cd\u7642\u6548\u986f\u8457\uff1a\u4fe1\u9054\u751f\u7269\u5ba3\u4f48Mazdutide(IBI362) \u5728\u4e2d\u570b2\u578b\u7cd6\u5c3f\u75c5\u53d7\u8a66\u8005\u4e2d\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\u9054\u5230\u4e3b\u8981\u7d42\u9ede"},"content":{"rendered":"

\u7f8e\u570b\u820a\u91d1\u5c71\u548c\u4e2d\u570b\u8607\u5dde2022\u5e747\u670819\u65e5 \/\u7f8e\u901a\u793e\/ — \u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u80a1\u7968\u4ee3\u78bc\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u514d\u3001\u4ee3\u8b1d\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u5275\u65b0\u85e5\u7269\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u4f48\uff1a\u80f0\u9ad8\u8840\u7cd6\u7d20\u6a23\u80bd-1\u53d7\u9ad4\uff08glucagon-like peptide-1 receptor, GLP-1R\uff09\/\u80f0\u9ad8\u8840\u7cd6\u7d20\u53d7\u9ad4\uff08glucagon receptor, GCGR\uff09\u96d9\u91cd\u6fc0\u52d5\u5291mazdutide\uff08\u7814\u767c\u4ee3\u865f\uff1aIBI362\uff09\u5728\u4e2d\u570b2\u578b\u7cd6\u5c3f\u75c5\u53d7\u8a66\u8005\u4e2d\u7684\u4e00\u9805\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u5b89\u6170\u5291\/\u5ea6\u62c9\u7cd6\u80bd\u5c0d\u7167\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\u9054\u5230\u4e3b\u8981\u7d42\u9ede\u3002<\/p>\n

\u6b64\u9805\u7814\u7a76\uff08ClinicalTrials.gov, NCT04965506\uff09\u65e8\u5728\u8a55\u4f30mazdutide\u5728\u7d93\u81f3\u5c113\u500b\u6708\u751f\u6d3b\u65b9\u5f0f\u5e72\u9810\u4f34\u6216\u8005\u4e0d\u4f34\u7a69\u5b9a\u5291\u91cf\u4e8c\u7532\u96d9\u80cd\u6cbb\u7642\u5f8c\u7cd6\u5316\u8840\u7d05\u86cb\u767d\uff08HbA1c\uff09\u4ecd\u4e0d\u9054\u6a19\u7684\u4e2d\u570b2\u578b\u7cd6\u5c3f\u75c5\u53d7\u8a66\u8005\u4e2d\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u5171\u5165\u7d44252\u4f8b\u53d7\u8a66\u8005\uff0c\u96a8\u6a5f\u63a5\u53d7mazdutide 3.0 mg\u30014.5 mg\u62166.0 mg\u3001\u5b89\u6170\u5291\u6216\u5ea6\u62c9\u7cd6\u80bd1.5 mg\uff0c\u6bcf\u9031\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u7d66\u85e5\uff0c\u9023\u7e8c\u7d66\u85e520\u5468\uff08\u542b4\u5468\u62168\u5468\u6ef4\u5b9a\u671f\uff09\u3002\u7814\u7a76\u4e3b\u8981\u7d42\u9ede\u70ba\u8207\u5b89\u6170\u5291\u76f8\u6bd4\uff0c\u9023\u7e8c\u7d66\u85e520\u5468\u5f8cHbA1c\u8f03\u57fa\u7dda\u7684\u8b8a\u5316\u3002\u5404\u7d44\u53d7\u8a66\u8005\u5e73\u5747\u7cd6\u5c3f\u75c5\u75c5\u53f2\u70ba4.0~5.7\u5e74\uff0cHbA1c\u57fa\u7dda\u5e73\u5747\u503c\u57287.94%~8.16%\u4e4b\u9593\u3002<\/p>\n

\u8207\u5b89\u6170\u5291\u76f8\u6bd4\uff0cmazdutide\u5404\u5291\u91cf\u7d44\u5747\u80fd\u986f\u8457\u964d\u4f4e\u53d7\u8a66\u8005HbA1c\u6c34\u5e73\uff08\u8207\u5b89\u6170\u5291\u7d44\u76f8\u6bd4, p\u503c\u5747\u5c0f\u65bc0.0001\uff09\u3002\u7d66\u85e520\u5468\u5f8c\uff0cmazdutide\u5404\u5291\u91cf\u7d44HbA1c\u6c34\u5e73\u8f03\u57fa\u7dda\u8b8a\u5316\u7684\u6700\u5c0f\u4e8c\u4e58\u5747\u503c\u5206\u5225\u70ba\u22121.41%\uff0895%CI\uff1a\u22121.70, \u22121.13\uff1b3.0 mg\uff09\u3001\u22121.67%\uff08\u22121.95, \u22121.39\uff1b4.5 mg\uff09\u548c\u22121.54%\uff08\u22121.83, \u22121.25\uff1b6.0 mg\uff09\uff0c\u5ea6\u62c9\u7cd6\u80bd1.5 mg\u7d44\u70ba\u22121.35% (\u22121.63, \u22121.07)\uff0c\u5b89\u6170\u5291\u7d44\u70ba0.03%\uff08\u22120.25, 0.31\uff09\uff1bMazdutide\u7d44HbA1c < 7.0%\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u5206\u5225\u70ba62.8%\uff083.0 mg\uff09\u300174.4%\uff084.5 mg\uff09\u548c78.3%\uff086.0 mg\uff09\uff1b\u5ea6\u62c9\u7cd6\u80bd1.5 mg\u7d44\u70ba69.8%\uff0c\u5b89\u6170\u5291\u7d44\u70ba20.0%\u3002<\/p>\n

\u5728\u53d7\u8a66\u8005\u7684\u9ad4\u91cd\u7ba1\u7406\u65b9\u9762\uff0c\u8207\u5b89\u6170\u5291\u76f8\u6bd4\uff0cmazdutide\u5404\u5291\u91cf\u5747\u53ef\u986f\u8457\u964d\u4f4e\u9ad4\u91cd\uff0c\u4e14\u5448\u73fe\u5291\u91cf\u4f9d\u8cf4\u6027\u3002\u7d66\u85e520\u5468\u5f8c\uff0cMazdutide\u00a06.0 mg\u7d44\u9ad4\u91cd\u8f03\u57fa\u7dda\u767e\u5206\u6bd4\u8b8a\u5316\u7684\u6700\u5c0f\u4e8c\u4e58\u5747\u503c\u70ba\u22127.14%\uff0895%CI\uff1a\u22128.49, \u22125.79\uff09\uff0c\u5ea6\u62c9\u7cd6\u80bd1.5 mg\u7d44\u70ba\u22122.69%\uff08\u22124.02, \u22121.37\uff09\uff0c\u5b89\u6170\u5291\u7d44\u70ba\u22121.38%\uff08\u22122.70, \u22120.06\uff09\uff0c\u8207\u5ea6\u62c9\u7cd6\u80bd\u7d44\u548c\u5b89\u6170\u5291\u7d44\u76f8\u6bd4\uff0cp\u503c\u5747\u5c0f\u65bc0.0001\uff1bmazdutide 6.0 mg \u7d44HbA1c<7.0%\u4e14\u9ad4\u91cd\u8f03\u57fa\u7dda\u4e0b\u964d\u22655%\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u9ad8\u905452.2%\uff08\u5ea6\u62c9\u7cd6\u80bd1.5 mg\u7d44\u70ba14.0%\uff0c\u5b89\u6170\u5291\u7d44\u70ba0%\uff09\u3002<\/p>\n

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\u672c\u7814\u7a76\u7684\u6578\u64da\u9084\u5728\u9032\u4e00\u6b65\u6574\u7406\u548c\u5206\u6790\u4e2d\uff0c\u76f8\u95dc\u7d50\u679c\u5c07\u6703\u5728\u540c\u884c\u8a55\u5be9\u7684\u5b78\u8853\u671f\u520a\u767c\u8868\u3002<\/p>\n

CIBI362A201\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u4e2d\u65e5\u53cb\u597d\u91ab\u9662\u694a\u6587\u82f1\u6559\u6388\u8868\u793a\uff1a\u300c\u76ee\u524d\uff0c\u6211\u570b2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u4ecd\u5b58\u5728\u8840\u7cd6\u7e3d\u9ad4\u9054\u6a19\u7387\u504f\u4f4e\uff0c\u4e14\u60a3\u8005\u5f80\u5f80\u5408\u4f75\u591a\u7a2e\u5fc3\u8840\u7ba1\u98a8\u96aa\u56e0\u7d20\uff0c\u5982\u80a5\u80d6\u3001\u9ad8\u8102\u8840\u75c7\u3001\u51a0\u5fc3\u75c5\u3001\u8102\u80aa\u809d\u3001\u75db\u98a8\u7b49\u60c5\u6cc1\uff0c\u9019\u65e2\u589e\u52a0\u4e86\u60a3\u8005\u7684\u75be\u75c5\u8ca0\u64d4\uff0c\u4e5f\u7d66\u91ab\u751f\u6cbb\u7642\u589e\u52a0\u4e86\u96e3\u5ea6\u548c\u8907\u96dc\u6027\uff1b\u81e8\u5e8a\u4e0a\u8feb\u5207\u9700\u8981\u80fd\u6709\u7642\u6548\u78ba\u5207\uff0c\u5b89\u5168\u6027\u597d\uff0c\u7d66\u85e5\u4fbf\u6377\uff0c\u4f4e\u8840\u7cd6\u98a8\u96aa\u4f4e\uff0c\u4e14\u80fd\u5be6\u73fe\u591a\u7a2e\u5fc3\u8840\u7ba1\u7372\u76ca\u7684\u5275\u65b0\u85e5\u7269\u3002\u6211\u5f88\u9ad8\u8208\u5730\u770b\u5230\u65b0\u4e00\u4ee3GLP-1R\/ GCGR\u96d9\u91cd\u6fc0\u52d5\u5291mazdutide\uff0c\u5728\u4e2d\u570b2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u4e2d\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\u53d6\u5f97\u4e86\u6fc0\u52d5\u4eba\u5fc3\u7684\u7d50\u679c\uff0c\u4e0d\u50c5\u5c55\u793a\u51fa\u986f\u8457\u964d\u7cd6\u7642\u6548\uff0c\u5728\u6e1b\u91cd\u6307\u6a19\u4e0a\u9084\u5c55\u793a\u51fa\u512a\u6548\u65bc\u570b\u969b\u4e3b\u6d41\u85e5\u7269\u5ea6\u62c9\u7cd6\u80bd\u7684\u6548\u679c\u7684\u6f5b\u8cea\u3002\u6211\u76f8\u4fe1mazdutide\u4e00\u5b9a\u6703\u5728\u5373\u5c07\u958b\u5c55\u7684III\u671f\u7814\u7a76\u4e2d\u6709\u66f4\u51fa\u8272\u7684\u8868\u73fe\uff0c\u4e26\u671f\u5f85\u5176\u65e9\u65e5\u7533\u5831\u4e0a\u5e02\uff0c\u60e0\u53ca\u60a3\u8005\u3002\u300d<\/p>\n

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\u95dc\u65bc\u7cd6\u5c3f\u75c5<\/p>\n

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\u95dc\u65bcMazdutide\uff08IBI362\uff09<\/p>\n

Mazdutide\uff08IBI362\uff09\u662f\u4fe1\u9054\u751f\u7269\u88fd\u85e5\u8207\u79ae\u4f86\u88fd\u85e5\u5171\u540c\u63a8\u9032\u7684\u4e00\u6b3e\u80c3\u6ccc\u9178\u8abf\u7bc0\u7d20\u5275\u65b0\u5316\u5408\u7269\uff08OXM3\uff09\uff0c\u5728\u540c\u985e\u7522\u54c1\u4e2d\u5177\u6709\u6700\u512a\u6f5b\u529b\u3002\u4f5c\u70ba\u4e00\u7a2e\u8207\u54fa\u4e73\u52d5\u7269\u80c3\u6ccc\u9178\u8abf\u7bc0\u7d20\u985e\u4f3c\u7684\u9577\u6548\u5408\u6210\u80bd\uff0cmazdutide\u5229\u7528\u8102\u80aa\u9170\u57fa\u5074\u93c8\u5ef6\u9577\u4f5c\u7528\u6642\u9593\uff0c\u5141\u8a31\u6bcf\u9031\u7d66\u85e5\u4e00\u6b21\u3002mazdutide\u7684\u4f5c\u7528\u88ab\u8a8d\u70ba\u662f\u901a\u904eGLP-1R\u548cGCGR\u7684\u7d50\u5408\u548c\u6fc0\u6d3b\u4ecb\u5c0e\u7684\uff0c\u8207OXM\u5177\u6709\u76f8\u4f3c\u4f5c\u7528\u6a5f\u5236\uff0c\u56e0\u6b64\u9810\u8a08\u5176\u53ef\u4ee5\u6539\u5584\u8461\u8404\u7cd6\u8010\u91cf\u4e26\u6e1b\u8f15\u9ad4\u91cd\u3002\u9664\u4e86GLP-1R\u6fc0\u52d5\u5291\u5177\u6709\u7684\u4fc3\u9032\u80f0\u5cf6\u7d20\u5206\u6ccc\u3001\u964d\u4f4e\u8840\u7cd6\u548c\u6e1b\u8f15\u9ad4\u91cd\u7b49\u4f5c\u7528\u5916\uff0cmazdutide\u9084\u53ef\u80fd\u901a\u904eGCGR\u7684\u6fc0\u6d3b\u5177\u6709\u589e\u52a0\u80fd\u91cf\u6d88\u8017\u548c\u6539\u5584\u809d\u81df\u8102\u80aa\u4ee3\u8b1d\u7b49\u6548\u61c9\u3002\u901a\u904e\u958b\u767c\u540c\u6642\u6fc0\u52d5\u591a\u500b\u8207\u4ee3\u8b1d\u76f8\u95dc\u7684\u9776\u9ede\u4f86\u6cbb\u7642\u4ee3\u8b1d\u6027\u75be\u75c5\u662f\u76ee\u524d\u570b\u969b\u4e0a\u65b0\u85e5\u7814\u767c\u6700\u65b0\u7684\u8da8\u52e2\u3002<\/p>\n

\u95dc\u65bc\u4fe1\u9054\u751f\u7269<\/p>\n

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\u4fe1\u9054\u751f\u7269\u5df2\u7d44\u5efa\u4e86\u4e00\u652f\u5177\u6709\u570b\u969b\u5148\u9032\u6c34\u5e73\u7684\u9ad8\u7aef\u751f\u7269\u85e5\u958b\u767c\u3001\u7522\u696d\u5316\u4eba\u624d\u5718\u968a\uff0c\u5305\u62ec\u773e\u591a\u6d77\u6b78\u5c08\u5bb6\uff0c\u4e26\u8207\u7f8e\u570b\u79ae\u4f86\u88fd\u85e5\u3001Adimab\u3001Incyte\u3001MD Anderson \u764c\u75c7\u4e2d\u5fc3\u548c\u97d3\u570bHanmi\u7b49\u570b\u969b\u5408\u4f5c\u65b9\u9054\u6210\u6230\u7565\u5408\u4f5c\u3002\u4fe1\u9054\u751f\u7269\u5e0c\u671b\u548c\u5927\u5bb6\u4e00\u8d77\u52aa\u529b\uff0c\u63d0\u9ad8\u4e2d\u570b\u751f\u7269\u88fd\u85e5\u7522\u696d\u7684\u767c\u5c55\u6c34\u5e73\uff0c\u4ee5\u6eff\u8db3\u767e\u59d3\u7528\u85e5\u53ef\u53ca\u6027\u548c\u4eba\u6c11\u5c0d\u751f\u547d\u5065\u5eb7\u7f8e\u597d\u9858\u671b\u7684\u8ffd\u6c42\u3002\u8a73\u60c5\u8acb\u8a2a\u554f\u516c\u53f8\u7db2\u7ad9\uff1awww.innoventbio.com<\/a>\u6216\u516c\u53f8\u9818\u82f1\u8cec\u865fwww.linkedin.com\/company\/innovent-biologics\/<\/a>\u3002<\/p>\n

\u8072\u660e\uff1a<\/p>\n

1. \u8a72\u9069\u61c9\u75c7\u70ba\u7814\u7a76\u4e2d\u7684\u85e5\u54c1\u7528\u6cd5\uff0c\u5c1a\u672a\u5728\u4e2d\u570b\u7372\u6279\uff1b
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\u524d\u77bb\u6027\u8072\u660e<\/p>\n

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