{"id":30872,"date":"2026-03-13T10:06:00","date_gmt":"2026-03-13T02:06:00","guid":{"rendered":"https:\/\/www.franchise.com.hk\/%e9%9b%b2%e9%a0%82%e6%96%b0%e8%80%80%e5%90%88%e4%bd%9c%e5%a4%a5%e4%bc%b4%e6%96%b0%e6%a9%8b%e7%94%9f%e7%89%a9%e8%88%87visara%e5%ae%a3%e4%bd%88vis-101-iia%e6%9c%9f%e8%87%a8%e5%ba%8a%e5%9c%a8%e6%bf%95\/30872"},"modified":"2026-03-13T10:06:00","modified_gmt":"2026-03-13T02:06:00","slug":"%e9%9b%b2%e9%a0%82%e6%96%b0%e8%80%80%e5%90%88%e4%bd%9c%e5%a4%a5%e4%bc%b4%e6%96%b0%e6%a9%8b%e7%94%9f%e7%89%a9%e8%88%87visara%e5%ae%a3%e4%bd%88vis-101-iia%e6%9c%9f%e8%87%a8%e5%ba%8a%e5%9c%a8%e6%bf%95","status":"publish","type":"post","link":"https:\/\/www.franchise.com.hk\/zh-hans\/%e9%9b%b2%e9%a0%82%e6%96%b0%e8%80%80%e5%90%88%e4%bd%9c%e5%a4%a5%e4%bc%b4%e6%96%b0%e6%a9%8b%e7%94%9f%e7%89%a9%e8%88%87visara%e5%ae%a3%e4%bd%88vis-101-iia%e6%9c%9f%e8%87%a8%e5%ba%8a%e5%9c%a8%e6%bf%95\/30872","title":{"rendered":"\u96f2\u9802\u65b0\u8000\u5408\u4f5c\u5925\u4f34\u65b0\u6a4b\u751f\u7269\u8207Visara\u5ba3\u4f48VIS-101 IIa\u671f\u81e8\u5e8a\u5728\u6fd5\u6027AMD\u53d6\u5f97\u7a4d\u6975\u9802\u7dda\u6578\u64da"},"content":{"rendered":"

VIS-101\u662f\u4e00\u6b3e\u9776\u5411VEGF-A\/ANG-2\u7684\u65b0\u578b\u56db\u50f9\u96d9\u7279\u7570\u6027\u6297\u9ad4\uff0c\u6191\u501f\u5176\u5275\u65b0\u7684\u56db\u50f9\u8a2d\u8a08\uff0c\u65e8\u5728\u6210\u70ba\u6cbb\u7642\u8996\u7db2\u819c\u8840\u7ba1\u75be\u75c5\u7684\u6f5b\u5728\u540c\u985e\u6700\u4f73\uff08Best-in-class\uff09\u85e5\u7269 IIa\u671f\u9802\u7dda\u6578\u64da\u986f\u793a\uff0cVIS-101\u5728\u6cbb\u7642\u6fd5\u6027\u5e74\u9f61\u76f8\u95dc\u6027\u9ec3\u6591\u8b8a\u6027\uff08\u6fd5\u6027AMD\uff09\u6642\uff0c\u5c55\u793a\u51fa\u8d77\u6548\u8fc5\u901f\u3001\u5f37\u6548\u6301\u4e45\u7684\u6cbb\u7642\u53cd\u61c9
\n\u60a3\u8005\u5e73\u5747\u6700\u4f73\u77ef\u6b63\u8996\u529b\uff08BCVA\uff09\u6539\u5584\u8d85\u904e10\u500bETDRS\u5b57\u6bcd\uff0c\u4e2d\u592e\u8996\u7db2\u819c\u539a\u5ea6\uff08CST\uff09\u6539\u5584\u4e2d\u4f4d\u6578\u5728100-150\u03bcm\u4e4b\u9593
\n \u8a72\u85e5\u7269\u5177\u6709\u6f5b\u5728\u300c\u540c\u985e\u6700\u4f73\u300d\u7684\u6301\u4e45\u6027
\n\u7d042\/3\u7684\u60a3\u8005\u57284\u500b\u6708\u5167\u7121\u9700\u518d\u6b21\u6cbb\u7642\uff0c\u7d04\u534a\u6578\u60a3\u8005\u57286\u500b\u6708\u5167\u7121\u9700\u518d\u6b21\u6cbb\u7642
\n \u5b89\u5168\u6027\u826f\u597d\uff0c\u672a\u89c0\u5bdf\u5230\u5291\u91cf\u9650\u5236\u6027\u6bd2\u6027 \u57fa\u65bc\u7a4d\u6975\u7684\u81e8\u5e8a\u6578\u64da\uff0cVisara\u9810\u8a08\u5c07\u65bc2026\u5e74\u4e0b\u534a\u5e74\u555f\u52d5IIb\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u4e26\u65bc2027\u5e74\u555f\u52d5\u5168\u7403III\u671f\u81e8\u5e8a\u7814\u7a76 <\/p>\n

\u4e0a\u6d77<\/span>2026\u5e743\u670813\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u96f2\u9802\u65b0\u8000\uff08HKEX 1952.HK\uff09\u7684\u5408\u4f5c\u5925\u4f34\u65b0\u6a4b\u751f\u7269\uff08\u7d0d\u65af\u9054\u514b\u80a1\u7968\u4ee3\u78bc\uff1aNBP\uff0c\u4e0b\u7a31\u300c\u65b0\u6a4b\u751f\u7269\u300d\uff09\u53ca\u5176\u63a7\u80a1\u5b50\u516c\u53f8Visara, Inc.\uff08\u4ee5\u4e0b\u7c21\u7a31\u300cVisara\u300d\uff09\u5ba3\u4f48\uff0c\u5728\u7814\u773c\u79d1\u7ba1\u7ddaVIS-101\u6cbb\u7642\u6fd5\u6027\u5e74\u9f61\u76f8\u95dc\u6027\u9ec3\u6591\u8b8a\u6027(\u6fd5\u6027AMD)\u7684IIa\u671f\u7814\u7a76\u53d6\u5f97\u7a4d\u6975\u9802\u7dda\u6578\u64da\u3002\u6578\u64da\u986f\u793a\uff0cVIS-101\u5c55\u793a\u51fa\u8d77\u6548\u8fc5\u901f\u3001\u5f37\u6548\u6301\u4e45\u7684\u6cbb\u7642\u53cd\u61c9\uff0c\u53ca\u826f\u597d\u7684\u5b89\u5168\u6027\u53ca\u8010\u53d7\u6027\uff0c\u4e26\u9a57\u8b49\u4e86\u5176\u4f5c\u70ba\u6f5b\u5728\u300c\u540c\u985e\u6700\u4f73\u300d\uff08Best-in-class\uff09\u6301\u4e45\u6027\u7684\u81e8\u5e8a\u50f9\u503c\u3002<\/p>\n

IIa\u671f\u81e8\u5e8a\u7814\u7a76\u9802\u7dda\u6578\u64da\u986f\u793a\uff0cVIS-101\u57283\u6beb\u514b\u548c6\u6beb\u514b\u5291\u91cf\u7d44\u4e2d\uff0c\u5747\u986f\u793a\u51fa\u8d77\u6548\u8fc5\u901f\u3001\u5f37\u6548\u6301\u4e45\u7684\u6cbb\u7642\u53cd\u61c9\uff0c\u53ca\u826f\u597d\u7684\u5b89\u5168\u6027\u53ca\u8010\u53d7\u6027<\/p>\n

\u5f37\u6548\u7684\u81e8\u5e8a\u61c9\u7b54
\n\u60a3\u8005\u5e73\u5747\u6700\u4f73\u77ef\u6b63\u8996\u529b\uff08BCVA\uff09\u6539\u5584\u8d85\u904e10\u500bETDRS\u5b57\u6bcd \u4e2d\u592e\u8996\u7db2\u819c\u539a\u5ea6\uff08CST\uff09\u6539\u5584\u4e2d\u4f4d\u6578\u5728100-150\u03bcm\u4e4b\u9593
\n \u5177\u6709\u6f5b\u5728\u300c\u540c\u985e\u6700\u4f73\u300d\u7684\u6301\u4e45\u6027
\n\u7d042\/3\u7684\u60a3\u8005\u57284\u500b\u6708\u5167\u7121\u9700\u518d\u6b21\u6cbb\u7642 \u7d04\u534a\u6578\u60a3\u8005\u57286\u500b\u6708\u5167\u7121\u9700\u518d\u6b21\u6cbb\u7642
\n \u5b89\u5168\u6027\u53ca\u8010\u53d7\u6027\u826f\u597d\uff0c\u672a\u89c0\u5bdf\u5230\u5291\u91cf\u9650\u5236\u6027\u6bd2\u6027 <\/p>\n

VIS-101\u662f\u4e00\u6b3e\u9776\u5411 VEGF-A\/ANG2 \u7684\u65b0\u578b\u56db\u50f9\u96d9\u7279\u7570\u6027\u6297\u9ad4\uff0c\u65e8\u5728\u70ba\u6fd5\u6027\u5e74\u9f61\u76f8\u95dc\u6027\u9ec3\u6591\u8b8a\u6027\uff08\u6fd5\u6027AMD\uff09\u3001\u7cd6\u5c3f\u75c5\u6027\u9ec3\u6591\u6c34\u816b\uff08DME\uff09\u53ca\u8996\u7db2\u819c\u975c\u8108\u963b\u585e\uff08RVO\uff09\u7b49\u8996\u7db2\u819c\u8840\u7ba1\u75be\u75c5\u63d0\u4f9b\u65b0\u4e00\u4ee3\u6cbb\u7642\u89e3\u6c7a\u65b9\u6848\u3002\u64da\u7d71\u8a08\uff0c\u5168\u7403\u6709\u8d85\u904e2000\u842c\u4eba\u53d7\u6fd5\u6027AMD\u5f71\u97ff[1]\uff0cVIS-101\u4ee4\u4eba\u632f\u596e\u7684\u7814\u7a76\u9032\u5c55\u6709\u671b\u5927\u5e45\u63a8\u52d5\u8a72\u75be\u75c5\u7684\u6cbb\u7642\u6548\u679c\uff0c\u6539\u5584\u5168\u7403\u60a3\u8005\u751f\u6d3b\u8cea\u91cf\u3002<\/p>\n

\u96f2\u9802\u65b0\u8000\u9996\u5e2d\u57f7\u884c\u5b98\u7f85\u6c38\u6176\u5148\u751f\u8868\u793a\uff1a\u300c\u6211\u5011\u975e\u5e38\u9ad8\u8208\u770b\u5230\u5408\u4f5c\u5925\u4f34\u5728 VIS 101 IIa \u671f\u7814\u7a76\u4e2d\u53d6\u5f97\u4e86\u7a4d\u6975\u7684\u9802\u7dda\u7d50\u679c\u3002<\/p>\n

\u6211\u5011\u6ce8\u610f\u5230\uff0cVEGF-A\/ANG-2\u96d9\u9776\u9ede\u6291\u5236\u5df2\u88ab\u9a57\u8b49\u4f5c\u70ba\u8996\u7db2\u819c\u8840\u7ba1\u75be\u75c5\u7684\u6838\u5fc3\u65b9\u5411\uff0c\u800c\u7642\u6548\u7684\u6301\u4e45\u6027\u662f\u7576\u524d\u4e9f\u9700\u6eff\u8db3\u7684\u95dc\u9375\u81e8\u5e8a\u9700\u6c42\u3002<\/p>\n

\u5f9eVIS-101 IIa\u671f\u6578\u64da\u4f86\u770b\uff0c\u50c5\u4e09\u6b21\u8ca0\u8377\u5291\u91cf\u6ce8\u5c04\u5f8c\uff0c\u7d04\u534a\u6578\u65e2\u5f80\u672a\u63a5\u53d7\u6cbb\u7642\u7684\u60a3\u8005\u5be6\u73fe\u4e86\u9577\u9054\u516d\u500b\u6708\u7684\u7121\u5fa9\u6cbb\u9593\u9694\uff0c\u5c55\u73fe\u51fa\u986f\u8457\u7684\u7642\u6548\u6301\u4e45\u6027\u3002\u540c\u6642\uff0c\u6578\u64da\u9084\u986f\u793a\u51fa\u5176\u5728\u8996\u529b\u548c\u89e3\u5256\u5b78\u6539\u5584\u4e0a\u7684\u5f37\u52c1\u6f5b\u529b\uff0c\u4ee5\u53ca\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u9019\u4e9b\u7d50\u679c\u5145\u5206\u9ad4\u73fe\u4e86\u5176\u5728\u81e8\u5e8a\u958b\u767c\u4e2d\u7684\u6f5b\u529b\uff0c\u4e26\u63d0\u4f9b\u6709\u529b\u652f\u6301\u3002<\/p>\n

VIS-101 \u517c\u5177\u9ad8\u5ea6\u5dee\u7570\u5316\u548c\u5546\u696d\u6f5b\u529b\u3002\u57fa\u65bc\u96d9\u65b9\u5df2\u9054\u6210\u7684\u6230\u7565\u5408\u4f5c\uff0c\u6211\u5011\u5c07\u4f9d\u6258\u96f2\u9802\u65b0\u8000\u8c50\u5bcc\u7684\u81e8\u5e8a\u958b\u767c\u7d93\u9a57\u548c\u6210\u719f\u7684\u5275\u65b0\u85e5\u5546\u696d\u5316\u5e73\u53f0\uff0c\u7a4d\u6975\u63a8\u52d5\u9019\u6b3e\u6f5b\u5728\u540c\u985e\u6700\u4f73\u7684\u96d9\u529f\u80fd\u751f\u7269\u5236\u5291\u5728\u4e2d\u570b\u53ca\u4e9e\u6d32\u5730\u5340\u7684\u81e8\u5e8a\u958b\u767c\u8207\u5546\u696d\u5316\uff0c\u76e1\u5feb\u70ba\u60a3\u8005\u63d0\u4f9b\u9019\u4e00\u5275\u65b0\u6cbb\u7642\u9078\u64c7\u3002\u300d<\/p>\n

\u65b0\u6a4b\u751f\u7269\u8463\u4e8b\u6703\u526f\u4e3b\u5e2d\u3001Visara\u5275\u59cb\u4eba\u517c\u57f7\u884c\u4e3b\u5e2dEmmett T. Cunningham, Jr.\u535a\u58eb\u8868\u793a\uff1a\u300cVIS-101 IIa\u671f\u7814\u7a76\u53d6\u5f97\u4e86\u4ee4\u4eba\u9f13\u821e\u7684\u5b89\u5168\u6027\u548c\u6301\u4e45\u6027\u6578\u64da\uff0c\u9019\u4e0d\u50c5\u5370\u8b49\u4e86\u5176\u5728\u6fd5\u6027AMD\u6cbb\u7642\u4e2d\u5be6\u73fe\u4e86\u6700\u5927\u5316\u8996\u529b\u7372\u76ca\u7684\u6f5b\u529b\uff0c\u4e5f\u70ba\u5f8c\u7e8c\u81e8\u5e8a\u958b\u767c\u5960\u5b9a\u4e86\u5805\u5be6\u57fa\u790e\u3002\u57fa\u65bc\u9019\u4e00\u7a4d\u6975\u9032\u5c55\uff0c\u516c\u53f8\u6b63\u52a0\u901f\u63a8\u9032\u4e0b\u4e00\u968e\u6bb5\u7814\u767c\u8a08\u5283\u2014\u2014\u9810\u8a08\u65bc\u4eca\u5e74\u4e0b\u534a\u5e74\u555f\u52d5IIb\u671f\u5291\u91cf\u63a2\u7d22\u7814\u7a76\uff0c2027\u5e74\u555f\u52d5\u5168\u7403III\u671f\u81e8\u5e8a\u8a66\u9a57\u3002\u300d<\/p>\n

\u96f2\u9802\u65b0\u8000\u65bc2025\u5e7410\u670830\u65e5\u5ba3\u4f48\u8207Visara\u7c3d\u8a02\u5354\u8b70\uff0c\u7372\u5f97\u7368\u5bb6\u8a31\u53ef\uff0c\u5728\u5927\u4e2d\u83ef\u5340\u3001\u65b0\u52a0\u5761\u3001\u97d3\u570b\u53ca\u82e5\u5e72\u6771\u5357\u4e9e\u570b\u5bb6\u9032\u884c\u81e8\u5e8a\u958b\u767c\u3001\u751f\u7522\u548c\u5546\u696d\u5316VIS-101\u3002<\/p>\n

\u95dc\u65bcVIS-101\u6cbb\u7642\u6fd5\u6027AMD\u7684\u96a8\u6a5fIIa\u671f\u7814\u7a76<\/p>\n

\u60a3\u8005\u7279\u5fb5\uff1a\u8a72\u7814\u7a76\u5728\u4e2d\u570b\u5171\u5165\u7d4438\u4f8b\u6fd5\u6027AMD\u60a3\u8005\uff0c\u6db5\u84cb\u65e2\u5f80\u672a\u63a5\u53d7\u904e\u6cbb\u7642\u7684\u60a3\u8005\uff0c\u4ee5\u53ca\u66fe\u63a5\u53d7VEGF\u6cbb\u7642\u7684\u60a3\u8005\u3002\u60a3\u8005\u63092:1\u7684\u6bd4\u4f8b\u96a8\u6a5f\u5206\u914d\u81f36mg\u7d44\uff0825\u4f8b\uff09\u548c3mg\u7d44\uff0813\u4f8b\uff09\u3002<\/p>\n

\u60a3\u8005\u57fa\u7dda\u4eba\u53e3\u5b78\u7279\u5fb5\uff1a\u5169\u7d44\u60a3\u8005\u7684\u57fa\u7dda\u7279\u5fb5\u5177\u6709\u53ef\u6bd4\u6027\uff086mg\u5291\u91cf\u7d44\u4e2d\u65e2\u5f80\u63a5\u53d7\u904e\u6cbb\u7642\u7684\u60a3\u8005\u6bd4\u4f8b\u7565\u9ad8\uff09\u3002<\/p>\n

\n

IIa\u671f\u9802\u7dda\u6578\u64da<\/span><\/p>\n

\u57fa\u65bc6mg\u548c3mg\u5291\u91cf\u7d44\u7684\u60a3\u8005\u6578\u64da<\/span><\/p>\n

\u5291\u91cf\u7d44<\/span><\/p>\n

6mg<\/span><\/p>\n

\uff0825\u4f8b\uff09<\/span><\/p>\n

3mg<\/span><\/p>\n

\uff0813\u4f8b\uff09<\/span><\/p>\n

\u7e3d\u8a08<\/span><\/p>\n

\uff0838\u4f8b\uff09<\/span><\/p>\n

\u60a3\u8005\u5e73\u5747\u5e74\u9f61<\/span><\/p>\n

69.5\u6b72<\/span><\/p>\n

71.5\u6b72<\/span><\/p>\n

<\/p>\n

\u6027\u5225<\/span><\/p>\n

\uff08\u7537\/\u5973\uff09<\/span><\/p>\n

68%\/<\/span><\/p>\n

32%<\/span><\/p>\n

61.5%\/<\/span><\/p>\n

38.5%<\/span><\/p>\n

65.8%\/<\/span><\/p>\n

34.2%<\/span><\/p>\n

\u57fa\u7ddaBCVA\u5747\u503c<\/span><\/p>\n

\uff08\u5b57\u6bcd\u6578\uff09<\/span><\/p>\n

54.7<\/span><\/p>\n

52.3<\/span><\/p>\n

53.9<\/span><\/p>\n

\u57fa\u7ddaCST\u6539\u5584\u4e2d\u4f4d\u6578<\/span><\/p>\n

\uff08\u03bcm\uff09<\/span><\/p>\n

417.2<\/span><\/p>\n

407.6<\/span><\/p>\n

413.9<\/span><\/p>\n

\u662f\u5426\u63a5\u53d7\u904e\u6297VEGF\u6cbb\u7642<\/span><\/p>\n

\uff08\u6709\/\u7121\uff09<\/span><\/p>\n

52%\/<\/span><\/p>\n

48%<\/span><\/p>\n

30.8%\/<\/span><\/p>\n

69.2%<\/span><\/p>\n

44.7%\/<\/span><\/p>\n

55.3%<\/span><\/p>\n<\/div>\n

\u5b89\u5168\u6027\uff1aVIS-101\u8868\u73fe\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u7279\u5fb5\uff0c\u672a\u89c0\u5bdf\u5230\u5291\u91cf\u9650\u5236\u6027\u6bd2\u6027\uff08DLT\uff09<\/p>\n

\u6cbb\u7642\u76f8\u95dc\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TEAEs\uff09\u767c\u751f\u7387\uff1a\u57283mg\u5291\u91cf\u7d44\u70ba0%\uff080\u4f8b\uff09\uff0c\u57286mg\u5291\u91cf\u7d44\u70ba8%\uff082\u4f8b\uff09\uff0c\u5747\u70ba\u5169\u500b\u4e0d\u540c\u60a3\u8005\u5404\u767c\u751f1\u4f8b\u4e8b\u4ef6\uff1b \u5728\u6cbb\u7642\u671f\u4e0d\u826f\u4e8b\u4ef6\u4e2d\uff0c\u672a\u767c\u73fe\u5b89\u5168\u6027\u4fe1\u865f\u3002 <\/p>\n

\u7814\u7a76\u76ee\u7684\u8207\u4e3b\u8981\u7d42\u9ede\uff1a\u9019\u9805\u96a8\u6a5fIIa\u671f\u7814\u7a76\uff08NCT05456832\uff09\u65e8\u5728\u8a55\u4f30VIS-101\u5728\u6cbb\u7642\u6fd5\u6027AMD\u60a3\u8005\u6642\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u7814\u7a76\u4e3b\u8981\u7d42\u9ede\u70ba\u5b89\u5168\u6027\u548c\u85e5\u4ee3\u52d5\u529b\u5b78\u7279\u5fb5\uff0c\u6b21\u8981\u7d42\u9ede\u70ba\u6709\u6548\u6027\uff0c\u8a55\u50f9\u6307\u6a19\u5305\u62ec\uff1a\u6700\u4f73\u77ef\u6b63\u8996\u529b\uff08BCVA\uff09\u8f03\u57fa\u7dda\u7684\u8b8a\u5316\uff08\u63a1\u7528ETDRS\u5b57\u6bcd\u91cf\u8868\u8a55\u4f30\uff09\u3001\u4e2d\u592e\u8996\u7db2\u819c\u539a\u5ea6\uff08CST\uff09\u8b8a\u5316\uff0c\u4ee5\u53ca\u518d\u6cbb\u7642\u7387\u3002<\/p>\n

\u53d7\u8a66\u8005\u5728\u7b2c0\u30014\u30018\u5468\u63a5\u53d7\u4e09\u6b21\u8ca0\u8377\u5291\u91cf\u7d66\u85e5\u5f8c\uff0c\u6bcf\u6708\u96a8\u8a2a\u4e00\u6b21\u76f4\u81f3\u7b2c36\u5468\uff1b\u6216\u6839\u64da\u65b9\u6848\u9810\u8a2d\u7684\u75be\u75c5\u6d3b\u52d5\u6a19\u6e96\uff08\u57fa\u65bcBCVA\u3001CST\u53ca\u6fd5\u6027AMD\u6d3b\u52d5\u6027\u8a55\u4f30\uff09\uff0c\u5224\u5b9a\u9700\u518d\u6cbb\u7642\u6642\u63d0\u524d\u7d42\u6b62\u96a8\u8a2a\u3002\u6bcf\u6b21\u8a2a\u8996\u5747\u5c0d\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7d42\u9ede\u9032\u884c\u8a55\u4f30\uff0c\u5305\u62ec\u672b\u6b21\u8ca0\u8377\u5291\u91cf\u5f8c24\u5468\uff086\u500b\u6708\uff09\u7684\u8a2a\u8996\u3002<\/p>\n

\u95dc\u65bcVIS-101<\/p>\n

VIS-101\uff08\u53c8\u540dASKG712\u6216AM712) \u662f\u4e00\u6b3e\u9776\u5411 VEGF-A\/ANG-2 \u7684\u65b0\u578b\u96d9\u7279\u7570\u6027\u751f\u7269\u5236\u5291\uff0c\u5206\u5b50\u6d3b\u6027\u66f4\u5f37\u3002\u76f8\u8f03\u73fe\u884c\u6a19\u6e96\u7642\u6cd5\uff0c\u8a72\u85e5\u7269\u6709\u671b\u70ba\u6fd5\u6027\u5e74\u9f61\u76f8\u95dc\u6027\u9ec3\u6591\u8b8a\u6027\uff08\u6fd5\u6027 AMD\uff09\u3001\u7cd6\u5c3f\u75c5\u6027\u9ec3\u6591\u6c34\u816b\uff08DME\uff09\u53ca\u8996\u7db2\u819c\u975c\u8108\u963b\u585e\uff08RVO\uff09\u60a3\u8005\u63d0\u4f9b\u66f4\u6709\u6548\u66f4\u6301\u4e45\u7684\u6cbb\u7642\u7372\u76ca\u3002VIS-101 \u5df2\u5728\u7f8e\u570b\u548c\u4e2d\u570b\u5b8c\u6210\u521d\u6b65\u7684\u5b89\u5168\u6027\u53ca\u5291\u91cf\u905e\u589e\u7814\u7a76\uff0c\u76ee\u524d\u6b63\u5728\u4e2d\u570b\u5b8c\u6210\u4e00\u9805\u96a8\u6a5f\u5c0d\u7167\u5291\u91cf\u7bc4\u570d II \u671f\u7814\u7a76\u3002IIa\u671f\u9802\u7dda\u6578\u64da\u986f\u793a\uff0cVIS-101\u5728\u6cbb\u7642\u6fd5\u6027AMD\u6642\u7522\u751f\u4e86\u8d77\u6548\u8fc5\u901f\u3001\u5f37\u6548\u4e14\u6301\u4e45\u7684\u6cbb\u7642\u53cd\u61c9\uff0c\u5b89\u5168\u6027\u53ca\u8010\u53d7\u6027\u826f\u597d\uff0c\u5177\u6709\u6f5b\u5728\u300c\u540c\u985e\u6700\u4f73\u300d\u7684\u6301\u4e45\u6027\uff0c\u4ee5\u53ca\u540c\u985e\u6700\u4f73\u7642\u6cd5\u7684\u6f5b\u529b\u3002\u8a72\u85e5\u7269IIb\u671f\u81e8\u5e8a\u7814\u7a76\u9810\u8a08\u5c07\u65bc2026\u5e74\u4e0b\u534a\u5e74\u555f\u52d5\uff0c\u5168\u7403III\u671f\u81e8\u5e8a\u7814\u7a76\u9810\u8a08\u65bc2027\u5e74\u555f\u52d5\u3002<\/p>\n

\n

\u4fe1\u606f\u4f86\u6e90\uff1a
1.\u300a\u773c\u79d1\u7814\u7a76\u8207\u8996\u89ba\u79d1\u5b78\uff08Investigative Ophthalmology & Visual Science\uff09\u300b\uff0c2021\u5e7411\u670824\u65e5\uff1b\u7b2c62\u5377\uff0814\u671f\uff09\uff1a\u7b2c26\u9801\u3002doi\uff1a10.1167\/iovs.62.14.26<\/span><\/p>\n<\/div>\n

\u95dc\u65bc\u96f2\u9802\u65b0\u8000<\/p>\n

\u96f2\u9802\u65b0\u8000\u662f\u4e00\u5bb6\u5c08\u6ce8\u65bc\u5275\u65b0\u85e5\u7814\u767c\u3001\u81e8\u5e8a\u958b\u767c\u3001\u88fd\u9020\u548c\u5546\u696d\u5316\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u6eff\u8db3\u5168\u7403\u5e02\u5834\u5c1a\u672a\u6eff\u8db3\u7684\u91ab\u7642\u9700\u6c42\u3002\u96f2\u9802\u65b0\u8000\u7684\u7ba1\u7406\u5718\u968a\u5728\u4e2d\u570b\u53ca\u5168\u7403\u9818\u5148\u88fd\u85e5\u4f01\u696d\u64c1\u6709\u6df1\u539a\u7684\u5c08\u9577\u548c\u8c50\u5bcc\u7684\u7d93\u9a57\u3002\u516c\u53f8\u5728\u6d59\u6c5f\u5609\u5584\u64c1\u6709\u5177\u5099\u5546\u696d\u5316\u898f\u6a21\u7684\u5168\u7403\u751f\u7522\u57fa\u5730\uff0c\u4e26\u56b4\u683c\u6309\u7167\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u548c\u6b50\u6d32\u85e5\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u7684GMP\u8981\u6c42\u53ca\u4e16\u754c\u885b\u751f\u7d44\u7e54\uff08WHO\uff09PQ\u6a19\u6e96\u5efa\u8a2d\u3002<\/p>\n

\u516c\u53f8\u805a\u7126\u81ea\u8eab\u514d\u75ab\u3001\u773c\u79d1\u3001\u6025\u91cd\u75c7\u53caCKM\uff08\u5fc3\u8840\u7ba1\u3001\u814e\u81df\u53ca\u4ee3\u8b1d\uff09\u7b49\u75be\u75c5\u6cbb\u7642\u9818\u57df\uff0c\u5df2\u6253\u9020\u96c6\u5168\u6e20\u9053\u5546\u696d\u5316\u9ad4\u7cfb\u8207\u85e5\u54c1\u5168\u751f\u547d\u9031\u671f\u5546\u696d\u5316\u80fd\u529b\u65bc\u4e00\u9ad4\u7684\u5546\u696d\u5316\u5e73\u53f0\uff0c\u4e26\u4ee5\u64c1\u6709\u5168\u7403\u6b0a\u76ca\u7684\u81ea\u7814mRNA\u5e73\u53f0\u70ba\u57fa\u790e\uff0c\u6301\u7e8c\u63a8\u9032mRNA in vivo CAR-T\u8207mRNA\u816b\u7624\u75ab\u82d7\u7b49\u73fe\u6709\u7ba1\u7dda\uff0c\u540c\u6642\u901a\u904e\u5f15\u9032\u53ca\u751f\u614b\u5b75\u5316\u6f5b\u529b\u5e73\u53f0\uff0c\u62d3\u5c55\u7814\u767c\u80fd\u529b\uff0c\u540c\u6642\u5f37\u5316\u5168\u7403\u5316\u4f48\u5c40\uff0c\u52a0\u5feb\u570b\u969b\u5316\u767c\u5c55\u9032\u7a0b\u3002\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\u516c\u53f8\u5b98\u7db2\uff1awww.everestmedicines.com<\/a>\u3002<\/p>\n

\u95dc\u65bcVISARA<\/p>\n

Visara \u662f\u4e00\u5bb6\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u5c08\u6ce8\u65bc\u958b\u767c\u540c\u985e\u6700\u4f73\u7684\u773c\u79d1\u6cbb\u7642\u85e5\u7269\u3002\u8a72\u516c\u53f8\u7531\u806f\u5408\u5275\u59cb\u4eba\u517c\u57f7\u884c\u8463\u4e8b\u9577 Emmett T. Cunningham, Jr. \u535a\u58eb\u548c\u9996\u5e2d\u91ab\u5b78\u5b98Cadmus Rich\u535a\u58eb\u9818\u5c0e\u3002Cunningham\u535a\u58eb\u662f\u4e00\u4f4d\u91ab\u751f\u3001\u5275\u65b0\u8005\u3001\u4f01\u696d\u5bb6\u548c\u6295\u8cc7\u8005\uff0c\u4e5f\u662f\u570b\u969b\u516c\u8a8d\u7684\u611f\u67d3\u6027\u548c\u708e\u75c7\u6027\u773c\u75c5\u5c08\u5bb6\u3002\u81ea2026\u5e742\u6708\u8d77\uff0c \u4ed6\u64d4\u4efb\u65b0\u6a4b\u751f\u7269\u8463\u4e8b\u6703\u526f\u4e3b\u5e2d\uff0c\u4e26\u4f5c\u70ba\u516c\u53f8\u8463\u4e8b\u6703\u7814\u767c\u59d4\u54e1\u6703\u6210\u54e1\u8ca0\u8cac\u63a8\u52d5\u85e5\u7269\u5275\u65b0\u7814\u767c\u3002\u4f5c\u70ba\u65b0\u6a4b\u751f\u7269\u5b50\u516c\u53f8 Visara, Inc.\u806f\u5408\u5275\u59cb\u4eba\uff0c Cunningham \u535a\u58eb\u5728Visara\u53ca\u591a\u5bb6\u751f\u547d\u79d1\u5b78\u516c\u53f8\u8463\u4e8b\u6703\u4efb\u8077\u3002Cunningham \u535a\u58eb\u57282018\u5e7411\u6708\u81f32023\u5e743\u6708\u64d4\u4efb\u9ed1\u77f3\u96c6\u5718\uff08The Blackstone Group Inc.\uff09\u9ad8\u7d1a\u8463\u4e8b\u7e3d\u7d93\u7406\uff0c\u96a8\u5f8c\u64d4\u4efb\u57f7\u884c\u9867\u554f\uff0c\u4e26\u65bc2023\u5e7412\u6708\u5f9e\u8a72\u516c\u53f8\u9000\u4f11\u3002\u6b64\u524d\uff0cCunningham\u535a\u58eb\u65bc2006\u5e74Clarus Ventures\u5275\u7acb\u4e4b\u521d\u5373\u52a0\u5165\u4e26\u64d4\u4efb\u8463\u4e8b\u7e3d\u7d93\u7406\u3002\u5728Clarus\u88ab\u9ed1\u77f3\u96c6\u5718\u6536\u8cfc\u5f8c\uff0c\u4ed6\u96a8\u4e4b\u52a0\u5165\u9ed1\u77f3\uff0c\u7e7c\u7e8c\u64d4\u4efb\u9ad8\u7d1a\u8463\u4e8b\u7e3d\u7d93\u7406\u3002\u5728\u52a0\u5165 Clarus Ventures \u4e4b\u524d\uff0cCunningham \u535a\u58eb\u66fe\u5728 Eyetech Pharmaceuticals, Inc. \u64d4\u4efb\u91ab\u7642\u6230\u7565\u9ad8\u7d1a\u526f\u7e3d\u88c1\uff0c\u662f\u8a72\u516c\u53f8\u7684\u9818\u5c0e\u5718\u968a\u6210\u54e1\u4e4b\u4e00\u3002\u518d\u4e4b\u524d\uff0c\u4ed6\u66fe\u5728\u8f1d\u745e\u516c\u53f8\uff08Pfizer Inc.\uff09\u64d4\u4efb\u591a\u500b\u91cd\u8981\u8077\u4f4d\u3002<\/p>\n

Cadmus Rich\u535a\u58eb\u4e0d\u50c5\u662f\u4e00\u4f4d\u8cc7\u6df1\u4f01\u696d\u5bb6\uff0c\u4e5f\u662f\u7d93\u9a57\u8c50\u5bcc\u7684\u773c\u79d1\u85e5\u7269\u7814\u767c\u5c08\u5bb6\u3002\u65b0\u6a4b\u751f\u7269\u662f Visara \u7684\u63a7\u80a1\u80a1\u6771\uff0cVisara \u64c1\u6709 VIS-101 \u5728\u5927\u4e2d\u83ef\u5340\u53ca\u4e9e\u6d32\u67d0\u4e9b\u570b\u5bb6\u4ee5\u5916\u5168\u7403\u6b0a\u76ca\u7684\u7368\u5bb6\u8a31\u53ef\u3002\u6b64\u524d\uff0cVisara\u5df2\u8f49\u8b93\u5176\u7368\u5bb6\u8a31\u53ef\u5354\u8b70\u7d66\u96f2\u9802\u65b0\u8000(Everest Medicines\uff1b\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a1952)\uff0c\u6388\u4e88\u5176\u5728\u5927\u4e2d\u83ef\u5340\u53ca\u4e9e\u6d32\u67d0\u4e9b\u570b\u5bb6\u958b\u767c\u3001\u751f\u7522\u8207\u5546\u696d\u5316 VIS-101\u7684\u6b0a\u76ca\u3002<\/p>\n

\u95dc\u65bc\u65b0\u6a4b\u751f\u7269<\/p>\n

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\u524d\u77bb\u6027\u8072\u660e<\/p>\n

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