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<span>Inc<\/span>.\u9054\u6210\u6230\u7565\u4ea4\u53c9\u8a31\u53ef\u5354\u8b70\uff0c\u96d9\u65b9\u5c07\u5171\u540c\u7814\u767c\u65b0\u4e00\u4ee3\u9ad4\u5167\u57fa\u56e0\u7d44\u7de8\u8f2f\u7642\u6cd5\u3002<\/p>\n<p>\u6b64\u9805\u5408\u4f5c\u7d50\u5408\u4e86\u96d9\u65b9\u95dc\u9375\u4e14\u9ad8\u5ea6\u4e92\u88dc\u7684\u751f\u7269\u6280\u8853\uff0c\u5373ToolGen\u9802\u5c16\u7684\u57fa\u56e0\u7d44\u7de8\u8f2f\u5668(CRISPR-Cas9)\u5e73\u53f0\u8207\u5f15\u6b63\u57fa\u56e0\u884c\u696d\u9818\u5148\u7684\u8102\u8cea\u7d0d\u7c73\u7c92\uff08LNP\uff09\u905e\u9001\u7cfb\u7d71\uff0c\u65e8\u5728\u5171\u540c\u7814\u767c\u5275\u65b0\u7684\u57fa\u56e0\u7d44\u7de8\u8f2f\u7642\u6cd5\uff0c\u70ba\u81e8\u5e8a\u91ab\u6cbb\u672a\u80fd\u6eff\u8db3\u7684\u75be\u75c5\u63d0\u4f9b\u55ae\u6b21\u6cbb\u7642\u5373\u5b8c\u6210\uff08\u300c\u4e00\u6b21\u5b8c\u6210\u300d\uff09\u7684\u6cbb\u7642\u65b9\u6848\u3002<\/p>\n<p>\u9ad4\u5167\u57fa\u56e0\u7d44\u7de8\u8f2f\u7684\u6210\u529f\u4e0d\u50c5\u4f9d\u8cf4\u65bc\u9ad8\u7cbe\u6e96\u5ea6\u7684\u57fa\u56e0\u7d44\u7de8\u8f2f\u5668\uff0c\u4e5f\u9700\u4f7f\u7528\u5b89\u5168\u548c\u9ad8\u6548\u7684\u905e\u9001\u7cfb\u7d71\u628a\u57fa\u56e0\u7d44\u7de8\u8f2f\u85e5\u7269\u6e96\u78ba\u9001\u5230\u76ee\u6a19\u7d44\u7e54\u548c\u7d30\u80de\u3002\u6b64\u6b21\u5408\u4f5c\u5145\u5206\u767c\u63ee\u96d9\u65b9\u7684\u6280\u8853\u512a\u52e2\uff0c\u5728\u7814\u767c\u4e2d\u7522\u751f\u5f37\u5927\u7684\u5354\u540c\u6548\u76ca\u3002<\/p>\n<p>\u5f15\u6b63\u57fa\u56e0\u958b\u767c\u4e2d\u7684\u7814\u7a76\u6027\u85e5\u7269GEB-200\u662f\u4e00\u6b3e\u91dd\u5c0d\u52d5\u8108\u7ca5\u6a23\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u75c5\uff08ASCVD\uff09\u7684\u57fa\u56e0\u7d44\u7de8\u8f2f\u7642\u6cd5\u3002\u9ad4\u5167\u8102\u86cb\u767da\u00a0\uff08Lp(a)\uff09\u6c34\u6e96\u504f\u9ad8\u662f\u5c0dASCVD\u5df2\u77e5\u7684\u907a\u50b3\u6027\u98a8\u96aa\u56e0\u7d20\uff0c\u5f71\u97ff\u5168\u7403\u8fd1\u5169\u6210\u4eba\u53e3\u3002\u5f15\u6b63\u57fa\u56e0\u5c08\u6709\u4e26\u7d93\u512a\u5316\u7684\u8102\u8cea\u7d0d\u7c73\u7c92\u53ca\u5176\u4ed6\u95dc\u9375\u905e\u9001\u6280\u8853\u80fd\u628a\u57fa\u56e0\u7d44\u7de8\u8f2f\u5668\u5b89\u5168\u548c\u9ad8\u6548\u5730\u9001\u5230\u9ad4\u5167\uff0c\u70ba\u76f8\u95dc\u57fa\u56e0\u9032\u884c\u7de8\u8f2f\uff0c\u5f9e\u800c\u964d\u4f4eLp(a)\u7684\u6c34\u5e73\u3002\u6b64\u9805\u76ee\u56e0\u5177\u6709\u6f5b\u529b\u70ba\u73fe\u6709\u9700\u8981\u9577\u671f\u670d\u85e5\u7684\u5fc3\u8840\u7ba1\u75be\u75c5\u63d0\u4f9b\u300c\u4e00\u6b21\u5b8c\u6210\u300d\u7684\u66ff\u4ee3\u6cbb\u7642\u65b9\u6848\u800c\u5099\u53d7\u95dc\u6ce8\u3002<\/p>\n<p>ToolGen\u8207\u5f15\u6b63\u57fa\u56e0\u81eaGEB-200\u958b\u767c\u65e9\u671f\u5df2\u7dca\u5bc6\u5408\u4f5c\uff0c\u7d50\u5408\u5404\u81ea\u6280\u8853\u512a\u52e2\u63a8\u52d5\u9805\u76ee\u3002\u5169\u5bb6\u516c\u53f8\u8fd1\u671f\u5b8c\u6210\u5728\u975e\u4eba\u985e\u9748\u9577\u985e\u52d5\u7269\uff08NHP\uff09\u7684\u81e8\u5e8a\u524d\u7814\u7a76\uff0c\u6210\u529f\u9a57\u8b49\u7de8\u8f2f\u76ee\u6a19\u57fa\u56e0\u7684\u5b89\u5168\u6027\uff0c\u6a19\u8a8c\u8457\u9081\u5411\u63d0\u4ea4\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57(IND)\u7533\u8acb\u7684\u91cd\u8981\u91cc\u7a0b\u7891\u3002\u5c55\u671b\u672a\u4f86\uff0c\u5c07\u52a0\u901fGEB-200\u7684\u7814\u767c\u8207\u76e3\u7ba1\u7533\u8acb\u9032\u7a0b\uff0c\u4e26\u6839\u64da\u96d9\u65b9\u5354\u8b70\u63a2\u7d22\u5168\u7403\u6388\u6b0a\u6a5f\u9047\u3002<\/p>\n<p>\u5f15\u6b63\u57fa\u56e0\u806f\u5408\u5275\u59cb\u4eba\u517c\u8463\u4e8b\u9577\u912d\u5b97\u7acb\u6559\u6388\u8868\u793a\uff1a\u300c\u5f15\u6b63\u57fa\u56e0\u8207ToolGen\u5171\u540c\u79c9\u6301 \u300e\u651c\u624b\u540c\u5fc3\uff0c\u529b\u91cf\u500d\u589e\u300f\u7684\u7406\u5ff5\uff0c\u4e5f\u5f7c\u6b64\u56e0\u70ba\u64c1\u6709\u70ba\u75c5\u60a3\u8005\u5e36\u4f86\u5b89\u5168\u548c\u6709\u6548\u7684\u57fa\u56e0\u7d44\u7de8\u8f2f\u7642\u6cd5\u6b64\u4e00\u5171\u540c\u76ee\u6a19\u800c\u8d70\u5728\u4e00\u8d77\u3002\u6211\u5011\u5c0d\u8207ToolGen\u7c3d\u7f72\u9019\u4efd\u4ea4\u53c9\u8a31\u53ef\u5354\u8b70\u5c07GEB-200\u7684\u7814\u767c\u52a0\u901f\u9032\u5165\u81e8\u5e8a\u968e\u6bb5\u5145\u6eff\u671f\u5f85\u3002\u6b64\u6b21\u5408\u4f5c\u9ad4\u73fe\u4e86\u6211\u5011\u516c\u53f8\u9ad8\u901a\u91cfLNP\u6a19\u8a18\u7cfb\u7d71\u5728\u81e8\u5e8a\u8f49\u5316\u4e2d\u9ad8\u9810\u6e2c\u6027\u7684\u6280\u8853\u512a\u52e2\uff0c\u540c\u6642\u51f8\u986fToolGen\u5728CRISPR-Cas9\u57fa\u56e0\u7d44\u7de8\u8f2f\u5668\u65b9\u9762\u7684\u9802\u5c16\u6280\u8853\u3002\u300d<\/p>\n<p>ToolGen \u9996\u5e2d\u57f7\u884c\u5b98\u67f3\u5b97\u76f8\u535a\u58eb\u8868\u793a: \u300c\u6295\u8cc7\u8005\u65e5\u76ca\u91cd\u8996\u91dd\u5c0d\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u57fa\u56e0\u7d44\u7de8\u8f2f\u7642\u6cd5\u3002\u8de8\u570b\u85e5\u4f01\u79ae\u4f86\u516c\u53f8\u6700\u8fd1\u5c31\u4ee510\u5104\u7f8e\u5143\u9996\u671f\u8cbb\u7528\u548c\u6700\u591a3\u5104\u7f8e\u5143\u689d\u4ef6\u50f9\u503c\u6b0a\u76ca\u6536\u8cfcVerve Therapeutics\uff0c\u7576\u4e2d\u5728\u7814\u7ba1\u7dab\u5305\u62ec\u9776\u5411Lp(a)\u7684\u57fa\u56e0\u7de8\u8f2f\u7642\u6cd5\u3002ToolGen\u4eca\u6b21\u900f\u904e\u8207\u5f15\u6b63\u57fa\u56e0\u7684\u6230\u7565\u5408\u4f5c\uff0c\u76ee\u6a19\u662f\u628a\u6211\u5011\u5728\u57fa\u56e0\u7d44\u7de8\u8f2f\u5668\u7684\u9802\u5c16\u512a\u52e2\u7d50\u5408\u5979\u5011\u7684\u9ad8\u7aef\u905e\u9001\u6280\u8853\uff0c\u529b\u6c42\u5728\u57fa\u56e0\u7d44\u7de8\u8f2f\u6cbb\u7642\u9818\u57df\u5be6\u73fe\u7a81\u7834\uff0c\u5c07\u5275\u65b0\u7684\u300e\u4e00\u6b21\u5b8c\u6210\u300f\u6cbb\u7642\u65b9\u6848\u5e36\u7d66\u5168\u7403\u60a3\u8005\u3002\u300d<\/p>\n<p>\u95dc\u65bcToolGen<\/p>\n<p>\u7e3d\u90e8\u4f4d\u65bc\u97d3\u570b\u9996\u723e\u7684ToolGen\u662f\u4e00\u5bb6\u9818\u5148\u7684\u751f\u7269\u79d1\u6280\u4f01\u696d\uff0c\u64c1\u6709\u57fa\u56e0\u7d44\u7de8\u8f2f\u5668(CRISPR-Cas9)\u7684\u57fa\u790e\u5c08\u5229\uff0c\u5c08\u9580\u61c9\u7528\u65bc\u5c08\u5229\u6536\u76ca\u3001\u91ab\u5b78\u6cbb\u7642\u548c\u8fb2\u696d\u79d1\u5b78\u4e09\u500b\u6838\u5fc3\u9818\u57df\uff0c\u4ee5\u63a8\u52d5\u7814\u767c\u8207\u5546\u696d\u767c\u5c55\u3002CRISPR-Cas9\u4f5c\u70ba\u95dc\u9375\u57fa\u56e0\u7d44\u7de8\u8f2f\u6280\u8853\uff0c\u53ef\u7cbe\u6e96\u4fee\u6539\u7d30\u80de\u5167\u907a\u50b3\u8b8a\u7570\uff0c\u73fe\u5df2\u5ee3\u6cdb\u61c9\u7528\u65bc\u751f\u547d\u79d1\u5b78\u9818\u57df\u3002\u5176\u6838\u5fc3\u5c08\u5229\u5df2\u572810\u500b\u4e3b\u8981\u570b\u5bb6\u548c\u5730\u5340\u7372\u5f97\u53d7\u6b0a\uff0c\u5305\u62ec\u7f8e\u570b\u3001\u6b50\u6d32\u3001\u4e2d\u570b\u3001\u6fb3\u6d32\u548c\u65e5\u672c\u3002\u6b64\u5916\uff0c\u8a72\u6280\u8853\u5df2\u6388\u6b0a\u7d66\u884c\u696d\u8de8\u570b\u4f01\u696d\u5982\u5b5f\u5c71\u90fd\uff08Monsanto\uff09\u548c\u8cfd\u9ed8\u98db\u4e16\u723e\uff08Thermo Fisher Scientific\uff09\uff0c\u5c55\u73fe\u5168\u7403\u7af6\u722d\u512a\u52e2\u3002<\/p>\n<p>\u95dc\u65bc\u5f15\u6b63\u57fa\u56e0\u00a0GenEditBio <\/p>\n<p>\u5f15\u6b63\u57fa\u56e0\u6210\u7acb\u65bc\u00a02021 \u5e74\uff0c\u7e3d\u90e8\u4f4d\u65bc\u4e2d\u570b\u9999\u6e2f\uff0c\u662f\u4e00\u5bb6\u81e8\u5e8a\u968e\u6bb5\u7684\u57fa\u56e0\u6cbb\u7642\u521d\u5275\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u63d0\u4f9b\u5b89\u5168\u3001\u7cbe\u6e96\u3001\u53ef\u7de8\u7a0b\u548c\u53ef\u6839\u6cbb\u7684\u9ad4\u5167\u57fa\u56e0\u7d44\u7de8\u8f2f\u6cbb\u7642\u89e3\u6c7a\u65b9\u6848\uff08\u7c21\u7a31\u300cDNA \u624b\u8853\u300d\uff09\uff0c\u4ee5\u586b\u88dc\u81e8\u5e8a\u91ab\u6cbb\u672a\u80fd\u6eff\u8db3\u7684\u9700\u6c42\u3002\u516c\u53f8\u7684\u6838\u5fc3\u7814\u767c\u9818\u57df\u5305\u62ec\u65b0\u578b\u00a0Cas \u6838\u9178\u9176\u57fa\u56e0\u7d44\u7de8\u8f2f\u5668\u7684\u958b\u767c\uff0c\u4ee5\u53ca\u5229\u7528\u8102\u8cea\u7d0d\u7c73\u9846\u7c92\uff08LNP\uff09\u8207\u5de5\u7a0b\u5316\u86cb\u767d\u905e\u9001\u8f09\u9ad4\uff08PDV\uff09\u5be6\u73fe\u5b89\u5168\u548c\u9ad8\u6548\u7684\u9ad4\u5167\u905e\u9001\u3002\u516c\u53f8\u5728\u9999\u6e2f\u3001\u5317\u4eac\u548c\u6ce2\u58eb\u9813\u8a2d\u6709\u7814\u7a76\u5be6\u9a57\u5ba4\u548c\u8fa6\u516c\u5ba4\u3002\u5f15\u6b63\u57fa\u56e0\u7531\u9802\u7d1a\u751f\u547d\u79d1\u5b78\u6295\u8cc7\u8005\u8cc7\u52a9\uff0c\u5305\u62ec\u555f\u660e\u5275\u6295\u3001\u65b9\u5713\u8cc7\u672c\u3001\u665f\u5fb7\u3001\u9806\u5929\u91ab\u85e5\u3001\u9999\u6e2f\u79d1\u6280\u5712\u5275\u6295\u57fa\u91d1\u7b49\u3002\u5982\u8981\u66f4\u591a\u8cc7\u8a0a\uff0c\u8acb\u5230\u8a2a\u516c\u53f8\u7db2\u9801<a href=\"http:\/\/www.geneditbio.com\/\" target=\"_blank\" rel=\"noopener\">www.geneditbio.com<\/a>\u3002<\/p>\n<p><span>ToolGen<\/span><\/p>\n<p class=\"prntaj\"><span>\u806f\u7e6b\u6211\u5011<\/span><span>(<\/span><span>\u6295\u8cc7\u8005<\/span><span>)<br \/><\/span><a href=\"mailto:Ig.lee@toolgen.com\" target=\"_blank\" rel=\"noopener\"><span>Ig.lee@toolgen.com<\/span><\/a><\/p>\n<p class=\"prntaj\"><span>\u5f15\u6b63\u57fa\u56e0<\/span><\/p>\n<p class=\"prntaj\"><span>\u806f\u7e6b\u6211\u5011<\/span><span>(<\/span><span>\u5a92\u9ad4<\/span><span>)<br \/><\/span><a href=\"mailto:geb.media@geneditbio.com\" target=\"_blank\" rel=\"noopener\"><span>geb.media@geneditbio.com<\/span><\/a><\/p>\n<p class=\"prntaj\"><span>\u806f\u7e6b\u6211\u5011<\/span><span>(<\/span><span>\u6295\u8cc7\u8005<\/span><span>)<br \/><\/span><a href=\"mailto:bd@geneditbio.com\" target=\"_blank\" rel=\"noopener\"><span>bd@geneditbio.com<\/span><\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>\u7d50\u5408 ToolGen \u9802\u5c16\u7684\u57fa\u56e0\u7d44\u7de8\u8f2f\u5668(CRISPR-Cas9) 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