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\u6578\u64da\u6458\u8981<\/p>\n

01 \u7de8\u865f\uff1aP-45
\u82f1\u6587\u6a19\u984c\uff1aBeyond Nine Months: Real – World Efficacy and Safety of Extended Nefecon Therapy in IgA Nephropathy
\u4e2d\u6587\u6a19\u984c\uff1a\u8d85\u8d8a\u4e5d\u6708\u4e4b\u9650\uff1a\u5ef6\u9577\u8010\u8ce6\u5eb7\u00ae\u6cbb\u7642\u5728IgA\u814e\u75c5\u4e2d\u7684\u771f\u5be6\u4e16\u754c\u7642\u6548\u8207\u5b89\u5168\u6027
\u5167\u5bb9\u6982\u8ff0\uff1a\u65e8\u5728\u8a55\u4f30\u8010\u8ce6\u5eb7\u00ae\u5728\u771f\u5be6\u4e16\u754c\u4e2d\u5c0dIgA\u814e\u75c5\u60a3\u8005\u9032\u884c12\u500b\u6708\u6cbb\u7642\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\uff0c\u4e26\u8207\u50b3\u7d71\u6cbb\u7642\u9032\u884c\u6bd4\u8f03\u3002\u7d50\u679c\u986f\u793a\uff0c12\u500b\u6708\u7684\u8010\u8ce6\u5eb7\u00ae\u6cbb\u7642\u53ef\u986f\u8457\u964d\u4f4eIgA\u814e\u75c5\u60a3\u8005\u7684\u86cb\u767d\u5c3f\u4e26\u4fdd\u8b77\u814e\u529f\u80fd\uff0c\u4e14\u8207\u50b3\u7d71\u7684\u5168\u8eab\u7cd6\u76ae\u8cea\u6fc0\u7d20\u53ca\u514d\u75ab\u6291\u5236\u5291\u6cbb\u7642\u76f8\u6bd4\uff0c\u5177\u6709\u66f4\u597d\u7684\u5b89\u5168\u6027\u3002
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\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u6b50\u967d\u6893\u83ef\uff0c\u6fb3\u9580\u93e1\u6e56\u91ab\u9662<\/p>\n

02 \u7de8\u865f\uff1aP-44
\u82f1\u6587\u6a19\u984c\uff1aEfficacy and Safety of Nefecon in IgA Nephropathy: A 6-Month Retrospective Cohort Study
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03 \u7de8\u865f\uff1aP-43
\u82f1\u6587\u6a19\u984c\uff1aBudesonide enteric capsules for IgA nephropathy with hepatitis B virus infection: Two cases
\u4e2d\u6587\u6a19\u984c\uff1a\u5e03\u5730\u5948\u5fb7\u8178\u6eb6\u81a0\u56ca\u7528\u65bc\u5408\u4e26\u4e59\u578b\u809d\u708e\u75c5\u6bd2\u611f\u67d3\u7684IgA\u814e\u75c5\uff1a\u5169\u4f8b\u75c5\u4f8b\u5831\u544a
\u5167\u5bb9\u6982\u8ff0\uff1a\u65e8\u5728\u8a55\u4f30\u5e03\u5730\u5948\u5fb7\u8178\u6eb6\u81a0\u56ca\u5728\u540c\u6642\u60a3\u6709IgA\u814e\u75c5\u548c\u6162\u6027\u4e59\u578b\u809d\u708e(HBV)\u60a3\u8005\u4e2d\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\u3002\u7d50\u679c\u986f\u793a\uff0c\u5e03\u5730\u5948\u5fb7\u8178\u6eb6\u81a0\u56ca\u806f\u5408\u5f37\u5316\u652f\u6301\u6cbb\u7642\u53ef\u6709\u6548\u6539\u5584\u4f34\u6709HBV\u5408\u4e26\u611f\u67d3\u7684IgA\u814e\u75c5\u60a3\u8005\u7684\u814e\u81df\u7d50\u5c40\uff0c\u4e14\u672a\u5f15\u767c\u75c5\u6bd2\u518d\u6fc0\u6d3b\u3002\u672c\u75c5\u4f8b\u5831\u544a\u70ba\u5e03\u5730\u5948\u5fb7\u8178\u6eb6\u81a0\u56ca\u5728\u9019\u4e00\u7279\u6b8a\u4eba\u7fa4\u4e2d\u7684\u4f7f\u7528\u63d0\u4f9b\u4e86\u5faa\u8b49\u4f9d\u64da\uff0c\u63d0\u793a\u5728\u56b4\u683c\u76e3\u6e2cHBV\u751f\u7269\u6a19\u8a8c\u7269\u7684\u524d\u63d0\u4e0b\uff0c\u901a\u904e\u9776\u5411\u8178\u9053\u514d\u75ab\u8abf\u7bc0\u56de\u8178\u6d3e\u723e\u96c6\u5408\u6dcb\u5df4\u7d50\u4e2d\u9ecf\u819cB\u7d30\u80de\u7684\u6578\u91cf\u548c\u6d3b\u6027\uff0c\u53ef\u80fd\u662f\u4e00\u7a2e\u512a\u9078\u7b56\u7565\u3002
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04 \u7de8\u865f\uff1aP-63
\u82f1\u6587\u6a19\u984c\uff1aFirst real-world evidence of Nefecon efficacy in pediatric patients with IgA nephropathy or IgA vasculitis nephritis
\u4e2d\u6587\u6a19\u984c\uff1a\u9996\u500b\u8010\u8ce6\u5eb7\u00ae\u5c0d\u5152\u7ae5IgA\u814e\u75c5\u6216IgA\u8840\u7ba1\u708e\u814e\u708e\u7684\u7642\u6548\u7684\u771f\u5be6\u4e16\u754c\u8b49\u64da
\u5167\u5bb9\u6982\u8ff0\uff1a\u65e8\u5728\u8a55\u4f30\u8010\u8ce6\u5eb7\u00ae\u5c0d\u5152\u7ae5IgA\u814e\u75c5\u6216IgA\u8840\u7ba1\u708e\u814e\u708e\u7684\u7642\u6548\u3002\u7d50\u679c\u986f\u793a\uff0c\u5728\u771f\u5be6\u4e16\u754c\u74b0\u5883\u4e2d\uff0c\u8010\u8ce6\u5eb7\u00ae\u5728\u5152\u7ae5IgA\u814e\u75c5\u6216IgA\u8840\u7ba1\u708e\u814e\u708e\uff08IgAVN\uff09\u60a3\u8005\u4e2d\u53ef\u986f\u8457\u964d\u4f4e\u86cb\u767d\u5c3f\u548c\u8840\u5c3f\u3002\u7136\u800c\uff0c\u5176\u5c0d\u4e0b\u4e18\u8166-\u5782\u9ad4-\u814e\u4e0a\u817a\u8ef8\u7684\u6f5b\u5728\u6291\u5236\u4ecd\u9700\u5f15\u8d77\u5152\u7ae5\u814e\u81df\u79d1\u91ab\u751f\u7684\u9ad8\u5ea6\u95dc\u6ce8\u8207\u8b39\u614e\u8a55\u4f30\u3002
\u4e3b\u8981\u4f5c\u8005\u53ca\u91ab\u9662\uff1a\u5f35\u745c\u3001\u5468\u5efa\u83ef\uff0c\u83ef\u4e2d\u79d1\u6280\u5927\u5b78\u540c\u6fdf\u91ab\u5b78\u9662\u9644\u5c6c\u540c\u6fdf\u91ab\u9662<\/p>\n

05 \u7de8\u865f\uff1aP-64
\u82f1\u6587\u6a19\u984c\uff1aEfficacy and Safety Profile of Nefecon in 26 Chinese Patients with IgA Nephropathy: A Real-World Observational Study
\u4e2d\u6587\u6a19\u984c\uff1a\u8010\u8ce6\u5eb7\u00ae\u6cbb\u764226\u4f8b\u4e2d\u570bIgA\u814e\u75c5\u60a3\u8005\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\u7279\u5fb5\uff1a\u4e00\u9805\u771f\u5be6\u4e16\u754c\u89c0\u5bdf\u6027\u7814\u7a76
\u5167\u5bb9\u6982\u8ff0\uff1a\u65e8\u5728\u8a55\u4f30\u8010\u8ce6\u5eb7\u00ae\u5728\u4e2d\u570bIgA\u814e\u75c5\u60a3\u8005\u4e2d\u7684\u771f\u5be6\u4e16\u754c\u81e8\u5e8a\u7642\u6548\u53ca\u5b89\u5168\u6027\u3002\u9019\u9805\u771f\u5be6\u4e16\u754c\u5206\u6790\u986f\u793a\uff0c\u8010\u8ce6\u5eb7\u00ae\u5728\u4e2d\u570bIgA\u814e\u75c5\u60a3\u8005\u4e2d\u5177\u6709\u6301\u7e8c\u7684\u814e\u81df\u4fdd\u8b77\u4f5c\u7528\uff0c\u5c24\u5176\u662f\u814e\u529f\u80fd\u5c1a\u53ef\uff08eGFR \u226535 mL\/min\/1.73m\u00b2\uff09\u7684\u60a3\u8005\uff0c\u8868\u73fe\u70ba\u86cb\u767d\u5c3f\u9010\u6b65\u4e0b\u964d\u548c\u8840\u5c3f\u6d88\u9000\u3002\u826f\u597d\u7684\u5b89\u5168\u6027\u9032\u4e00\u6b65\u652f\u6301\u5176\u5728\u8a72\u4eba\u7fa4\u4e2d\u7684\u81e8\u5e8a\u61c9\u7528\u50f9\u503c\u3002
\u4e3b\u8981\u4f5c\u8005\u53ca\u91ab\u9662\uff1a\u5f35\u8ecd\u8ecd\u3001\u8d99\u5360\u6b63\uff0c\u912d\u5dde\u5927\u5b78\u7b2c\u4e00\u9644\u5c6c\u91ab\u9662<\/p>\n

06 \u7de8\u865f\uff1aP-48
\u82f1\u6587\u6a19\u984c\uff1aNefecon Treatment in Patients with Primary IgA Nephropathy and Renal Insufficiency: A 6-Month Observational Study
\u4e2d\u6587\u6a19\u984c\uff1a\u8010\u8ce6\u5eb7\u00ae\u6cbb\u7642\u5408\u4e26\u814e\u529f\u80fd\u4e0d\u5168\u7684\u539f\u767c\u6027IgA\u814e\u75c5\u60a3\u8005\uff1a\u4e00\u9805\u70ba\u671f6\u500b\u6708\u7684\u89c0\u5bdf\u6027\u7814\u7a76
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\u4e3b\u8981\u4f5c\u8005\u53ca\u91ab\u9662\uff1a\u65b9\u660e\uff0c\u5927\u9023\u91ab\u79d1\u5927\u5b78\u9644\u5c6c\u7b2c\u4e00\u91ab\u9662<\/p>\n

07 \u7de8\u865f\uff1aP-62
\u82f1\u6587\u6a19\u984c\uff1aEarly Intervention with Budesonide Enteric-Coated Capsules in IgA Nephropathy: 2 Case Demonstrating Reduced Proteinuria and Stabilized Renal Function
\u4e2d\u6587\u6a19\u984c\uff1a\u5e03\u5730\u5948\u5fb7\u8178\u6eb6\u81a0\u56ca\u65e9\u671f\u5e72\u9810IgA\u814e\u75c5\uff1a\u5169\u4f8b\u986f\u793a\u86cb\u767d\u5c3f\u6e1b\u5c11\u548c\u7a69\u5b9a\u814e\u529f\u80fd\u7684\u75c5\u4f8b\u5831\u544a
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\u95dc\u65bc\u8010\u8ce6\u5eb7\u00ae\uff08NEFECON\u00ae\uff09<\/p>\n

\u8010\u8ce6\u5eb7\u00ae(NEFECON\u00ae)\u662f\u5e03\u5730\u5948\u5fb7\u8178\u6eb6\u81a0\u56ca\uff0c\u4f5c\u70ba\u5168\u7403\u9996\u500b\u5c0d\u56e0\u6cbb\u7642IgA\u814e\u75c5\u7684\u85e5\u7269\uff0c\u662f\u9776\u5411\u8178\u9053\u9ecf\u819cB\u7d30\u80de\u7684\u514d\u75ab\u8abf\u7bc0\u5291\uff0c\u80fd\u6e1b\u5c1150%\u814e\u529f\u80fd\u4e0b\u964d[1]<\/span>\uff0c\u5728\u4e2d\u570b\u4eba\u7fa4\u4e2d\u80fd\u5ef6\u7de9\u814e\u529f\u80fd\u8870\u9000\u905466%[2]<\/span>\uff0c\u9810\u8a08\u5c07\u75be\u75c5\u9032\u5c55\u81f3\u900f\u6790\u6216\u814e\u79fb\u690d\u7684\u6642\u9593\u5ef6\u7de912.8\u5e74[3]<\/span>\u3002\u540c\u6642\u5e03\u5730\u5948\u5fb7\u9996\u904e\u4ee3\u8b1d\u7387\u905490%[4]<\/span>\uff0c\u5177\u6709\u826f\u597d\u7684\u5b89\u5168\u6027\u3002\u8010\u8ce6\u5eb7\u00ae\u5c08\u70baIgA\u814e\u75c5\u60a3\u8005\u7814\u5236\uff0c\u6bcf\u9846\u81a0\u56ca\u542b\u5e03\u5730\u5948\u5fb74mg\uff0c\u901a\u904e\u7279\u6b8a\u7684\u9072\u91cb\u53ca\u7de9\u91cb\u96d9\u91cd\u5236\u5291\u5de5\u85dd\uff0c\u5c07\u5e03\u5730\u5948\u5fb7\u4e09\u5c64\u5305\u8863\u5fae\u4e38\u9776\u5411\u91cb\u653e\u65bc\u56de\u8178\u672b\u7aef\u7684\u9ecf\u819cB\u7d30\u80de\uff08\u5305\u62ec\u6d3e\u723e\u96c6\u5408\u6dcb\u5df4\u7d50\uff09\uff0c\u4e09\u5c64\u5305\u8863\u5fae\u4e38\u6301\u7e8c\u7a69\u5b9a\u91cb\u653e\u5e03\u5730\u5948\u5fb7\uff0c\u9ad8\u6fc3\u5ea6\u8986\u84cb\u6574\u500b\u9776\u5340\u57df\uff0c\u5f9e\u800c\u6e1b\u5c11\u8a98\u767cIgA\u814e\u75c5\u7684\u534a\u4e73\u7cd6\u7f3a\u9677\u7684IgA1\uff08Gd-IgA1\uff09\u7522\u751f\uff0c\u9032\u800c\u5e72\u9810\u767c\u75c5\u6a5f\u5236\u4e0a\u6e38\u968e\u6bb5\uff0c\u9054\u5230\u6cbb\u7642IgA\u814e\u75c5\u7684\u4f5c\u7528\u3002<\/p>\n

2019\u5e746\u6708\uff0c\u96f2\u9802\u65b0\u8000\u8207Calliditas Therapeutics \u7c3d\u8a02\u7368\u5bb6\u6388\u6b0a\u8a31\u53ef\u5354\u8b70\uff0c\u7372\u5f97\u5728\u5927\u4e2d\u83ef\u5730\u5340\u548c\u65b0\u52a0\u5761\u958b\u767c\u4ee5\u53ca\u5546\u696d\u5316\u8010\u8ce6\u5eb7\u00ae\u7684\u6b0a\u5229\u3002\u8a72\u5354\u8b70\u65bc2022\u5e743\u6708\u64f4\u5c55\uff0c\u5c07\u97d3\u570b\u7d0d\u5165\u96f2\u9802\u65b0\u8000\u7684\u6388\u6b0a\u8a31\u53ef\u7bc4\u570d\u3002<\/p>\n

\u95dc\u65bc\u96f2\u9802\u65b0\u8000<\/p>\n

\u96f2\u9802\u65b0\u8000\u662f\u4e00\u5bb6\u5c08\u6ce8\u65bc\u5275\u65b0\u85e5\u548c\u75ab\u82d7\u7814\u767c\u3001\u81e8\u5e8a\u958b\u767c\u3001\u88fd\u9020\u548c\u5546\u696d\u5316\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u6eff\u8db3\u4e9e\u6d32\u5e02\u5834\u5c1a\u672a\u6eff\u8db3\u7684\u91ab\u7642\u9700\u6c42\u3002\u96f2\u9802\u65b0\u8000\u7684\u7ba1\u7406\u5718\u968a\u5728\u4e2d\u570b\u53ca\u5168\u7403\u9818\u5148\u88fd\u85e5\u4f01\u696d\u5f9e\u4e8b\u904e\u9ad8\u8cea\u91cf\u7814\u767c\u3001\u81e8\u5e8a\u958b\u767c\u3001\u85e5\u653f\u4e8b\u52d9\u3001\u5316\u5b78\u88fd\u9020\u8207\u63a7\u5236\uff08CMC\uff09\u3001\u696d\u52d9\u767c\u5c55\u548c\u5546\u696d\u5316\u904b\u71df\uff0c\u64c1\u6709\u6df1\u539a\u7684\u5c08\u9577\u548c\u8c50\u5bcc\u7684\u7d93\u9a57\u3002\u96f2\u9802\u65b0\u8000\u5df2\u6253\u9020\u591a\u6b3e\u75be\u75c5\u9996\u5275\u6216\u8005\u540c\u985e\u6700\u4f73\u7684\u85e5\u7269\u7d44\u5408\uff0c\u516c\u53f8\u7684\u6cbb\u7642\u9818\u57df\u5305\u62ec\u814e\u79d1\u75be\u75c5\u3001\u611f\u67d3\u6027\u548c\u50b3\u67d3\u6027\u75be\u75c5\u3001\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3002\u6709\u95dc\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\u516c\u53f8\u7db2\u7ad9\uff1a www.everestmedicines.com<\/a>\u3002\u00a0<\/p>\n

\u524d\u77bb\u6027\u8072\u660e<\/p>\n

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\u53c2\u8003\u6587\u732e<\/span><\/p>\n

[1] Lafayette R,et al. Lancet. 2023 Sep 9<\/span>;402(10405):859-870.<\/span><\/p>\n

[2] 2023ASN. Oral presentation.<\/span><\/p>\n

[3] Jonathan Barratt,et al. 2023 ASN. Poster no. SA-PO886.<\/span><\/p>\n

[4] Edsb\u00e4cker S,et al. Aliment Pharmacol Ther. 1999 Feb;13(2):219-24.<\/span><\/p>\n

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