{"id":27819,"date":"2025-08-28T23:45:00","date_gmt":"2025-08-28T15:45:00","guid":{"rendered":"https:\/\/www.franchise.com.hk\/%e9%9b%b2%e9%a0%82%e6%96%b0%e8%80%80%e7%99%bc%e5%b8%832025%e5%b9%b4%e4%b8%ad%e6%9c%9f%e6%a5%ad%e7%b8%be%e5%8f%8a%e6%a5%ad%e5%8b%99%e9%80%b2%e5%b1%95\/27819"},"modified":"2025-08-28T23:45:00","modified_gmt":"2025-08-28T15:45:00","slug":"%e9%9b%b2%e9%a0%82%e6%96%b0%e8%80%80%e7%99%bc%e5%b8%832025%e5%b9%b4%e4%b8%ad%e6%9c%9f%e6%a5%ad%e7%b8%be%e5%8f%8a%e6%a5%ad%e5%8b%99%e9%80%b2%e5%b1%95","status":"publish","type":"post","link":"https:\/\/www.franchise.com.hk\/zh-hans\/%e9%9b%b2%e9%a0%82%e6%96%b0%e8%80%80%e7%99%bc%e5%b8%832025%e5%b9%b4%e4%b8%ad%e6%9c%9f%e6%a5%ad%e7%b8%be%e5%8f%8a%e6%a5%ad%e5%8b%99%e9%80%b2%e5%b1%95\/27819","title":{"rendered":"\u96f2\u9802\u65b0\u8000\u767c\u5e032025\u5e74\u4e2d\u671f\u696d\u7e3e\u53ca\u696d\u52d9\u9032\u5c55"},"content":{"rendered":"

\u4e0a\u6d77<\/span>2025\u5e748\u670829\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u96f2\u9802\u65b0\u8000\uff08<\/span>HKEX 1952.HK<\/span>\uff09\uff0c\u4e00\u5bb6\u5c08\u6ce8\u65bc\u5275\u65b0\u85e5\u53ca\u75ab\u82d7\u958b\u767c\u3001\u88fd\u9020\u53ca\u5546\u696d\u5316\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u4eca\u65e5\u516c\u5e03<\/span>2025<\/span>\u5e74\u5ea6\u4e2d\u671f\u696d\u7e3e\u5831\u544a\uff08\u622a\u81f3<\/span>2025<\/span>\u5e74<\/span>6<\/span>\u6708<\/span>30<\/span>\u65e5\uff09\u53ca\u696d\u52d9\u9032\u5c55\u3002<\/span><\/p>\n

\u96f2\u9802\u65b0\u8000\u9996\u5e2d\u57f7\u884c\u5b98\u7f85\u6c38\u6176\u8868\u793a\uff1a\u300c<\/span>2025<\/span>\u5e74\u4e0a\u534a\u5e74\uff0c\u96f2\u9802\u65b0\u8000\u901a\u904e\u6df1\u5316\u300e\u96d9\u8f2a\u9a45\u52d5\u300f\u6230\u7565\u6b63\u5728\u7a81\u7834\u6210\u70ba\u5168\u7403\u9818\u5148\u7684<\/span>Biopharma<\/span>\u516c\u53f8\uff0c\u6210\u529f\u69cb\u5efa\u4ee5\u958b\u767c\u9ad8\u6f5b\u529b\u85cd\u6d77\u5e02\u5834\u7684\u5927\u55ae\u54c1\u5546\u696d\u5316\u5e73\u53f0\u70ba\u57fa\u77f3\u3001\u4ee5\u81ea\u9ad4\u751f\u6210<\/span>CAR-T<\/span>\u5e73\u53f0\u8207<\/span>mRNA<\/span>\u816b\u7624\u6cbb\u7642\u6027\u75ab\u82d7\u5e73\u53f0\u7684\u81ea\u4e3b\u7814\u767c\u8207\u81e8\u5e8a\u8f49\u5316\u70ba\u5f15\u64ce\u7684\u50f9\u503c\u9ad4\u7cfb<\/span>\uff0c\u63a8\u52d5\u516c\u53f8\u5728\u5546\u696d\u5316\u8207\u7814\u767c\u5169\u5927\u9818\u57df\u5be6\u73fe\u7a81\u7834\u6027\u9032\u5c55\u3002<\/span><\/p>\n

\u516c\u53f82025\u5e74\u4e0a\u534a\u5e74\u7684\u7e3d\u6536\u5165\u9054\u4eba\u6c11\u5e634.46\u5104\u5143\uff0c\u540c\u6bd4\u589e\u957748%\uff0c\u904b\u71df\u8cbb\u7528\u4f54\u6536\u5165\u6bd4\u91cd\u5927\u5e45\u6e1b\u5c11<\/span>40.1<\/span>\u500b\u767e\u5206\u9ede\uff0c\u5c55\u73fe\u4e86\u5353\u8d8a\u7684\u904b\u71df\u6548\u7387<\/span>\uff1b\u975e\u570b\u969b\u8ca1\u52d9\u6e96\u5247\u8667\u640d\u7e3d\u984d\u986f\u8457\u6536\u7a8431%\uff1b\u5254\u9664\u975e\u73fe\u91d1\u9805\u76ee\u5f8c\u6bdb\u5229\u7387\u70ba76.4%\uff1b\u622a\u81f36\u6708\u5e95\uff0c\u73fe\u91d1\u5132\u5099\u5145\u88d5\uff0c\u9054\u4eba\u6c11\u5e6316\u5104\u5143\u3002\u6b64\u5916\uff0c\u516c\u53f8\u65bc8\u67081\u65e5\u5b8c\u6210\u914d\u80a1\u52df\u8cc7\uff0c\u52df\u8cc7\u6de8\u984d15.53\u5104\u6e2f\u5143\u5df2\u5230\u8cec\uff0c\u70ba\u5f8c\u7e8c\u696d\u52d9\u767c\u5c55\u63d0\u4f9b\u4e86\u5805\u5be6\u4fdd\u969c\u3002<\/p>\n

\u5546\u696d\u5316\u5c64\u9762<\/span>\uff0c\u516c\u53f8\u6838\u5fc3\u7522\u54c1\u6301\u7e8c\u91cb\u653e\u5e02\u5834\u6f5b\u529b\uff0c\u8010\u8ce6\u5eb7\u00ae<\/span>\u548c\u4f9d\u5609\u00ae<\/span>\u5be6\u73fe\u4e86\u53ef\u6301\u7e8c\u7684\u81ea\u6211\u9020\u8840\uff0c\u7dad\u9069\u5e73\u00ae<\/span>\uff08\u827e\u66f2\u83ab\u5fb7\uff09\u4f5c\u70ba\u4e0b\u4e00\u500b\u78ba\u5b9a\u6027\u5927\u55ae\u54c1\uff0c\u5c07\u6210\u70ba\u672a\u4f86\u65b0\u589e\u9577\u9ede\uff0c\u5171\u540c\u63a8\u52d5\u6574\u9ad4\u696d\u52d9\u5448\u73fe\u5f37\u52c1\u589e\u9577\u614b\u52e2\u3002<\/span><\/p>\n

\u814e\u75c5\u6cbb\u7642\u9818\u57df\u5927\u55ae\u54c1\u8010\u8ce6\u5eb7\u00ae\u4eca\u5e74\u4e0a\u534a\u5e74\u92b7\u552e\u6536\u5165\u9054\u4eba\u6c11\u5e633.03\u5104\u5143\uff0c\u540c\u6bd4\u589e\u957781%\u3002\u5728\u64f4\u7522\u88dc\u5145\u7533\u8acb\u7372\u6279\u5f8c\uff0c\u4f9b\u61c9\u80fd\u529b\u9032\u4e00\u6b65\u63d0\u5347\uff0c\u8010\u8ce6\u5eb7\u00ae1-8\u6708\u92b7\u552e\u6536\u5165\u5df2\u9054\u4eba\u6c11\u5e638.25\u5104\u5143\uff0c\u6062\u5fa9\u6b63\u5e38\u4f9b\u61c9\u5f8c\uff0c8\u6708\u55ae\u6708\u92b7\u552e\u6536\u5165\u9054\u4eba\u6c11\u5e635.20\u5104\u5143\uff0c\u9810\u8a08\u5168\u5e74\u92b7\u552e\u984d\u5c07\u9054\u4eba\u6c11\u5e6312-14\u5104\u5143\uff0c\u4e26\u5c07\u57282026\u5e74\u7e7c\u7e8c\u4fdd\u6301\u9ad8\u901f\u589e\u9577\uff0c\u9810\u8a08\u5c07\u9054\u4eba\u6c11\u5e6324-26\u5104\u5143\u3002 \u5168\u7403\u9996\u500b\u6c1f\u74b0\u7d20\u985e\u6297\u83cc\u85e5\u7269\u4f9d\u5609\u00ae\u6301\u7e8c\u7a69\u5065\u589e\u9577\uff0c\u4e0a\u534a\u5e74\u6536\u5165\u9054\u4eba\u6c11\u5e631.43\u5104\u5143\uff0c\u540c\u6bd4\u589e\u95776%\uff0c\u901a\u904e\u805a\u7126\u76ee\u6a19\u6838\u5fc3\u91ab\u9662\uff0c\u91ab\u9662\u7aef\u7d14\u92b7\u540c\u6bd4\u589e\u957737%\u3002 \u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u9818\u57df\u7684\u6700\u4f73\u85e5\u7269\u7dad\u9069\u5e73\u00ae\u5728\u4e2d\u570b\u5927\u9678\u7684\u4e0a\u5e02\u9032\u7a0b\u7a69\u6b65\u63a8\u9032\uff0c\u9810\u8a082026\u4e0a\u534a\u5e74\u7372\u6279\u4e0a\u5e02\u3002\u516c\u53f8\u5609\u5584\u672c\u5730\u5316\u751f\u7522\u5efa\u8a2d\u9805\u76ee\u5df2\u65bc\u4eca\u5e743\u6708\u6b63\u5f0f\u555f\u52d5\uff0c\u5c07\u70ba\u7dad\u9069\u5e73\u00ae\u7684\u5546\u696d\u5316\u63d0\u4f9b\u6709\u529b\u4fdd\u969c\u3002 <\/p>\n

\u57fa\u65bc\u8010\u8ce6\u5eb7\u00ae<\/span>\u5f37\u52c1\u7684\u5e02\u5834\u589e\u9577\u52e2\u982d\u8207\u4f9d\u5609\u00ae<\/span>\u7684\u7a69\u5065\u8868\u73fe\uff0c\u6211\u5011\u5c0d\u5be6\u73fe\u5168\u5e74\u4eba\u6c11\u5e63<\/span>16-18<\/span>\u5104\u5143\u7684\u92b7\u552e\u76ee\u6a19\u5145\u6eff\u4fe1\u5fc3\uff0c\u4e26\u5c07\u5728<\/span>Q4<\/span>\u5be6\u73fe\u7d93\u71df\u6027\u73fe\u91d1\u6d41\u8f49\u6b63\u3002<\/span><\/p>\n

\u81ea\u4e3b\u7814\u767c\u5c64\u9762<\/span>\uff0c<\/span>\u516c\u53f8\u6301\u7e8c\u805a\u7126\u81ea\u7814\u6838\u5fc3\u7ba1\u7dda\u7684\u95dc\u9375\u7a81\u7834\uff0c\u4e26\u52a0\u5feb\u5168\u7403\u6b0a\u76ca\u7522\u54c1\u7684\u81e8\u5e8a\u958b\u767c\u8207\u570b\u969b\u5316\u5e03\u5c40\u3002\u4f9d\u6258\u65bc\u696d\u5167\u9818\u5148\u7684\u81ea\u7814mRNA\u816b\u7624\u6cbb\u7642\u6027\u75ab\u82d7\u5e73\u53f0\u53ca\u81ea\u9ad4\u751f\u6210CAR-T\u5e73\u53f0\uff0c\u69cb\u5efa\u8d77\u5177\u5099\u5168\u7403\u7af6\u722d\u529b\u7684\u7814\u767c\u7ba1\u7dda\u3002<\/p>\n

\u81ea\u9ad4\u751f\u6210CAR-T\u9805\u76eeEVM18\u5df2\u5b8c\u6210\u591a\u9805\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\uff08\u7334\uff09\u7814\u7a76\uff0c\u4e26\u78ba\u5b9a\u81e8\u5e8a\u5019\u9078\u5206\u5b50\uff0c\u9810\u8a08\u65bc2025\u5e74\u5e95\u524d\u555f\u52d5\u81e8\u5e8a\u8a66\u9a57\u3002 \u500b\u6027\u5316\u816b\u7624\u6cbb\u7642\u6027\u75ab\u82d7EVM16\u5df2\u5728\u4e2d\u570b\u555f\u52d5\u9996\u6b21\u4eba\u9ad4\u81e8\u5e8a\u8a66\u9a57\u4e26\u5b8c\u6210\u60a3\u8005\u7d66\u85e5\uff1bIIT\u81e8\u5e8a\u8a66\u9a57\u5df2\u5b8c\u6210\u4f4e\u3001\u4e2d\u5291\u91cf\u7d44\u722c\u5761\uff0c\u521d\u6b65\u6578\u64da\u7a4d\u6975\u3002 \u901a\u7528\u578b\u73fe\u8ca8\u816b\u7624\u6cbb\u7642\u6027\u75ab\u82d7EVM14\u6ce8\u5c04\u6db2\u7684\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\uff08IND\uff09\u7533\u8acb\u5df2\u7372\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u548c\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u7684\u53d7\u7406\uff0c\u7f8e\u570bI\u671f\u81e8\u5e8a\u8a66\u9a57\u555f\u52d5\u4e2d\uff0c\u9810\u8a082025\u5e749\u6708\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u5165\u7d44\u3002 \u73fe\u8ca8\u578b\u514d\u75ab\u8abf\u7bc0\u75ab\u82d7EVM15\u5df2\u5b8c\u6210\u81e8\u5e8a\u524d\u6982\u5ff5\u9a57\u8b49\uff0c\u4e26\u78ba\u5b9a\u81e8\u5e8a\u5019\u9078\u5206\u5b50\u3002 \u65b0\u4e00\u4ee3\u5171\u50f9\u53ef\u9006BTK\u6291\u5236\u5291EVER001\uff08\u5e0c\u5e03\u66ff\u5c3c\uff09\u53d6\u5f97\u7a4d\u6975\u76841b\/2a\u671f\u81e8\u5e8a\u6578\u64da\uff0c\u5168\u7403\u7814\u767c\u9032\u7a0b\u7a69\u6b65\u63a8\u9032\u3002 <\/p>\n

\u516c\u53f8\u767c\u5c55\u5c64\u9762\uff0c\u8fd1\u671f\u4e00\u7cfb\u5217\u6230\u7565\u8209\u63aa\u70ba\u9577\u671f\u589e\u9577\u6ce8\u5165\u5f37\u52c1\u52d5\u529b\u3002<\/span>\u516c\u53f8\u901a\u904e\u5148\u820a\u5f8c\u65b0\u914d\u552e\u6210\u529f\u52df\u8cc7\uff0c\u9032\u4e00\u6b65\u5145\u5be6\u8cc7\u91d1\u5be6\u529b\uff0c\u52a0\u901f\u5275\u65b0\u7ba1\u7dda\u7814\u767c\u3001<\/span>AI+mRNA<\/span>\u5e73\u53f0\u5347\u7d1a\u53ca\u73fe\u6709\u7522\u54c1\u7684\u5546\u696d\u5316\u9032\u7a0b\u3002\u4eca\u5e74<\/span>4<\/span>\u6708\uff0c\u9999\u6e2f\u806f\u5408\u4ea4\u6613\u6240\u6279\u51c6\u79fb\u9664\u516c\u53f8\u80a1\u7968\u7c21\u7a31\u5f8c\u7684<\/span>\u300cB\u300d<\/span>\u6a19\u8a18\uff0c\u9ad4\u73fe\u4e86\u8cc7\u672c\u5e02\u5834\u5c0d\u516c\u53f8\u7814\u767c\u5be6\u529b\u3001\u5546\u696d\u5316\u9032\u7a0b\u53ca\u6574\u9ad4\u696d\u52d9\u57fa\u790e\u7684\u5145\u5206\u8a8d\u53ef\u3002\u6b64\u5916\uff0c\u516c\u53f8\u65bc<\/span>8<\/span>\u6708\u5b8c\u6210\u5c0d<\/span>I-Mab<\/span>\u7684\u6230\u7565\u6027\u80a1\u6b0a\u6295\u8cc7\uff0c\u9032\u4e00\u6b65\u63a8\u52d5\u4e86\u6211\u5011\u5728\u65b0\u4e00\u4ee3\u816b\u7624\u514d\u75ab\u6cbb\u7642\u9818\u57df\u7684\u5168\u7403\u5316\u5e03\u5c40\u3002<\/span><\/p>\n

\u6191\u501f\u7a69\u5065\u7684\u8cc7\u91d1\u5132\u5099\u548c\u4e0d\u65b7\u589e\u5f37\u7684\u7814\u767c\u53ca\u5546\u696d\u5316\u80fd\u529b\uff0c\u516c\u53f8\u529b\u722d\u5728<\/span>2025<\/span>\u5e74\u4e0b\u534a\u5e74\u5be6\u73fe\u7d93\u71df\u6027\u76c8\u5229\u3002<\/span><\/p>\n

\u5c55\u671b\u672a\u4f86\uff0c\u516c\u53f8\u5c07\u6301\u7e8c\u6df1\u5316<\/span>\u300c<\/span>\u96d9\u8f2a\u9a45\u52d5\u300d<\/span>\u6230\u7565\u5e03\u5c40\uff0c\u4e00\u65b9\u9762\u4f9d\u6258\u5f37\u5927\u7684\u5546\u696d\u5316\u5e73\u53f0\uff0c\u805a\u7126\u8010\u8ce6\u5eb7\u00ae<\/span>\u8207\u7dad\u9069\u5e73\u00ae<\/span>\u300c<\/span>\u96d9\u5927\u55ae\u54c1\u300d<\/span>\uff0c\u4e26\u6191\u501f\u4f9d\u5609\u00ae<\/span>\u3001\u982d\u5b62\u5421\u809f<\/span>–<\/span>\u4ed6\u5c3c\u787c\u5df4\u5766\u3001<\/span>EVER001<\/span>\uff08\u5e0c\u5e03\u66ff\u5c3c\uff09\u53ca\u66f4\u591a\u5f15\u9032\u54c1\u7a2e\u7b49<\/span>\u300c<\/span>\u9ad8\u6f5b\u7d44\u5408<\/span>\u300d<\/span>\uff0c\u767c\u63ee\u5354\u540c\u6548\u61c9\uff0c\u9810\u8a08\u672a\u4f86\u92b7\u552e\u5cf0\u503c\u8d85<\/span>250<\/span>\u5104\u5143\u3002<\/span><\/p>\n

\u53e6\u4e00\u65b9\u9762\uff0c\u57fa\u65bc<\/span>AI+mRNA<\/span>\u6280\u8853\u5e73\u53f0\u958b\u5c55\u65e9\u671f\u7814\u767c\uff0c\u63a8\u52d5\u7ba1\u7dda\u6709\u6a5f\u589e\u9577\u3002\u4f9d\u6258\u81ea\u9ad4\u751f\u6210<\/span>CAR-T<\/span>\u5e73\u53f0\u8207<\/span>mRNA<\/span>\u816b\u7624\u6cbb\u7642\u6027\u75ab\u82d7\u5e73\u53f0\uff0c\u70ba\u6301\u7e8c\u5275\u65b0\u548c\u570b\u969b\u5316\u767c\u5c55\u6ce8\u5165\u5f37\u52c1\u52d5\u529b\u3002<\/span>\u6301\u7e8c\u70ba\u60a3\u8005\u63d0\u4f9b\u5275\u65b0\u7642\u6cd5\uff0c\u70ba\u80a1\u6771\u5275\u9020\u9577\u671f\u50f9\u503c\uff0c\u529b\u722d\u6210\u70ba\u5168\u7403\u9818\u5148\u7684<\/span>Biopharma<\/span>\u3002\u300d<\/span><\/p>\n

\u6700\u65b0\u4e3b\u8981\u7522\u54c1\u4eae\u9ede\u548c\u9810\u671f\u91cc\u7a0b\u7891<\/span><\/p>\n

\u814e\u75c5\u7ba1\u7dda<\/span><\/p>\n

\u8010\u8ce6\u5eb7\u00ae<\/span>\uff08<\/span>NEFECON\u00ae<\/span>\uff09<\/span><\/p>\n

– 2025<\/span>\u5e74<\/span>1<\/span>\u6708\uff0c\u8010\u8ce6\u5eb7\u00ae<\/span>\u958b\u59cb\u57f7\u884c\u91ab\u4fdd\u65b0\u50f9\u683c\uff0c\u6b64\u524d\u8010\u8ce6\u5eb7\u00ae<\/span>\u65bc<\/span>2024<\/span>\u5e74<\/span>11<\/span>\u6708\u88ab\u7d0d\u5165\u570b\u5bb6\u91ab\u4fdd\u85e5\u54c1\u76ee\u9304\u3002\u60a3\u8005\u53ef\u5728\u5b9a\u9ede\u91ab\u7642\u6a5f\u69cb\u6216\u5b9a\u9ede\u85e5\u5e97\u8cfc\u8cb7\u8010\u8ce6\u5eb7\u00ae<\/span>\uff0c\u4e26\u4eab\u53d7\u91ab\u4fdd\u5831\u92b7\u50f9\u683c\u3002\u570b\u5bb6\u91ab\u4fdd\u85e5\u54c1\u76ee\u9304\u7684\u6b63\u5f0f\u5be6\u65bd\u63d0\u5347\u4e86\u8010\u8ce6\u5eb7\u00ae<\/span>\u7684\u53ef\u53ca\u6027\uff0c\u6e1b\u8f15\u60a3\u8005\u8ca0\u64d4\uff0c\u4f7f\u66f4\u591a\u4e2d\u570b<\/span>IgA<\/span>\u814e\u75c5\u60a3\u8005\u5f9e\u9019\u6b3e\u5275\u65b0\u85e5\u7269\u4e2d\u7372\u76ca\u3002<\/span><\/p>\n

– 2025<\/span>\u5e74<\/span>5<\/span>\u6708\uff0c\u8010\u8ce6\u5eb7\u00ae<\/span>\u6b63\u5f0f\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08<\/span>NMPA<\/span>\uff09\u6279\u51c6\uff0c\u7531\u9644\u689d\u4ef6\u6279\u51c6\u8f49\u70ba\u5b8c\u5168\u6279\u51c6\uff0c\u53d6\u6d88\u86cb\u767d\u5c3f\u6c34\u5e73\u9650\u5236\u3002\u9019\u4e00\u91cc\u7a0b\u7891\u610f\u5473\u8457\u8010\u8ce6\u5eb7\u00ae<\/span>\u6210\u70ba\u9996\u500b\u4e14\u552f\u4e00\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08<\/span>NMPA<\/span>\uff09\u5b8c\u5168\u6279\u51c6\u7684<\/span>IgA<\/span>\u814e\u75c5\u5c0d\u56e0\u6cbb\u7642\u85e5\u7269\u3002\u6b64\u6b21\u7372\u6279\u662f\u57fa\u65bc<\/span>NefIgArd III<\/span>\u671f\u81e8\u5e8a\u7814\u7a76\u7684\u5b8c\u6574\u6578\u64da\u3002<\/span>NefIgArd III<\/span>\u671f\u81e8\u5e8a\u8a66\u9a57\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5168\u7403\u591a\u4e2d\u5fc3\u7814\u7a76\uff0c\u5728\u63a5\u53d7<\/span>RAS<\/span>\u6291\u5236\u5291\u512a\u5316\u652f\u6301\u6cbb\u7642\u7684\u539f\u767c\u6027<\/span>IgA<\/span>\u814e\u75c5\u6210\u4eba\u60a3\u8005\u4e2d\u8a55\u4f30\u4e86\u8010\u8ce6\u5eb7\u00ae<\/span>\uff08<\/span>16mg<\/span>\uff0c\u6bcf\u65e5\u4e00\u6b21\uff09\u8207\u5b89\u6170\u5291\u76f8\u6bd4\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u3002<\/span><\/p>\n

– 2025<\/span>\u5e74<\/span>5<\/span>\u6708\uff0c\u8010\u8ce6\u5eb7\u00ae<\/span>\u88ab\u7d0d\u5165\u300a\u4e2d\u570b\u6210\u4eba<\/span>IgA<\/span>\u814e\u75c5\u53ca<\/span>IgA<\/span>\u8840\u7ba1\u708e\u81e8\u5e8a\u5be6\u8e10\u6307\u5357\uff08\u9810\u5be9\u7248\u672c\uff09\u300b\uff0c\u63a8\u85a6\u5c0d\u6709\u75be\u75c5\u9032\u5c55\u98a8\u96aa\u7684<\/span>IgA<\/span>\u814e\u75c5\u60a3\u8005\u9032\u884c<\/span>9<\/span>\u500b\u6708\u7684\u5e03\u5730\u5948\u5fb7\u8178\u6eb6\u81a0\u56ca\u5c0d\u56e0\u6cbb\u7642\uff0c\u4e0d\u53d7\u86cb\u767d\u5c3f\u6c34\u5e73\u7684\u9650\u5236\uff0c\u4ee5\u964d\u4f4e\u81f4\u75c5\u6027<\/span>IgA<\/span>\uff08<\/span>Gd-IgA1<\/span>\uff09\u3002\u6307\u5357\u5efa\u8b70\u5c0d\u65bc\u86cb\u767d\u5c3f\u2265<\/span>0.5 g\/d<\/span>\uff08\u6216\u540c\u7b49\u6c34\u5e73\uff09\u7684\u60a3\u8005\u5efa\u8b70\u814e\u6d3b\u6aa2\u4e26\u555f\u52d5\u6cbb\u7642\u3002\u540c\u6642\uff0c\u6307\u5357\u9996\u6b21\u63d0\u51fa\u91dd\u5c0d\u514d\u75ab\u6027\u640d\u50b7\u9032\u884c\u5e72\u9810\uff0c\u5305\u62ec\u63a1\u53d6\u6e1b\u5c11\u81f4\u75c5\u6027<\/span>IgA<\/span>\u7b49\u6cbb\u7642\u63aa\u65bd\u3002 \u6e1b\u5c11\u81f4\u75c5\u6027<\/span>IgA<\/span>\u7684\u6cbb\u7642\uff0c\u9996\u9078\u8010\u8ce6\u5eb7\u00ae<\/span>\u3002\u9054\u5230\u77ed\u671f\u6cbb\u7642\u76ee\u6a19\u5f8c\uff0c\u5373\u86cb\u767d\u5c3f\u7de9\u89e3\uff08\u86cb\u767d\u5c3f<\/span><0.5 g\/d<\/span>\uff0c\u7406\u60f3\u60c5\u6cc1<\/span><0.3 g\/d<\/span>\uff09\u53ca\u814e\u529f\u80fd\u7a69\u5b9a\uff0c\u53ef\u4ee5\u63a1\u53d6\u5c0f\u5291\u91cf\u7dad\u6301\u6216\u91cd\u8986\u5b89\u5168\u6709\u6548\u7684\u514d\u75ab\u6cbb\u7642\u548c\u7e7c\u7e8c\u7dad\u6301\u652f\u6301\u6cbb\u7642\uff0c\u4ee5\u4fdd\u8b49<\/span>eGFR<\/span>\u6bcf\u5e74\u4e0b\u964d<\/span><1 ml\/min<\/span>\u3002<\/span><\/p>\n

– 2025<\/span>\u5e74<\/span>6<\/span>\u6708\uff0c\u96f2\u9802\u65b0\u8000\u5728\u7b2c<\/span>62<\/span>\u5c46\u6b50\u6d32\u814e\u81df\u5354\u6703\uff08<\/span>ERA 2025<\/span>\uff09\u5927\u6703\u4e0a\uff0c\u5c55\u793a\u4e86\u8010\u8ce6\u5eb7\u00ae<\/span>9<\/span>\u9805\u6700\u65b0\u7814\u7a76\u6210\u679c\uff0c\u5305\u62ec<\/span>8<\/span>\u9805\u53e3\u982d\u5831\u544a\u548c<\/span>1<\/span>\u9805\u96fb\u5b50\u58c1\u5831\u3002\u6700\u65b0\u767c\u5e03\u7684\u7814\u7a76\u7d50\u679c\u6db5\u84cb\u4e86\u5f9e\u7642\u6548\u9810\u6e2c\u6a19\u8a8c\u7269\u5230\u4e0d\u540c\u8a3a\u65b7\u6642\u9593\u3001\u57fa\u7dda\u814e\u529f\u80fd\u6c34\u5e73\u60a3\u8005\u7684\u7642\u6548\u8a55\u4f30\uff0c\u4ee5\u53ca\u9577\u671f\u6cbb\u7642\u7684\u53ef\u6301\u7e8c\u6027\u5206\u6790\uff0c\u7279\u5225\u662f\u5c0d\u4f5c\u7528\u6a5f\u5236\u548c\u5b89\u5168\u6027\u7684\u63a2\u8a0e\u3002\u7814\u7a76\u8868\u660e\uff0c\u8010\u8ce6\u5eb7\u00ae<\/span>\u5c0d\u4e0d\u540c<\/span>eGFR<\/span>\u57fa\u7dda\u548c\u78ba\u8a3a\u6642\u9593\u7684<\/span>IgA<\/span>\u814e\u75c5\u60a3\u8005\u5747\u5177\u6709\u986f\u8457\u7684\u814e\u81df\u4fdd\u8b77\u4f5c\u7528\u3002 \u6b64\u6b21\u6703\u4e0a\u516c\u5e03\u7684\u8010\u8ce6\u5eb7\u00ae<\/span>\u591a\u9805\u6700\u65b0\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u5728\u75be\u75c5\u65e9\u671f\u4f7f\u7528\u8010\u8ce6\u5eb7\u00ae<\/span>\u53ef\u4f7f\u60a3\u8005\u7372\u5f97\u66f4\u986f\u8457\u7684\u814e\u529f\u80fd\u4fdd\u8b77\u548c\u5ef6\u7de9\u75be\u75c5\u9032\u5c55\uff0c\u70ba<\/span>IgA<\/span>\u814e\u75c5\u76e1\u65e9\u958b\u555f\u6e90\u982d\u5e72\u9810\u63d0\u4f9b\u4e86\u6709\u529b\u4f9d\u64da\uff0c\u70ba\u60a3\u8005\u5e36\u4f86\u4e86\u66f4\u79d1\u5b78\u7684\u6cbb\u7642\u65b9\u6848\u548c\u66f4\u597d\u7684\u751f\u6d3b\u8cea\u91cf\u3002\u9019\u4e9b\u7814\u7a76\u7d50\u679c\u652f\u6301\u300c\u5c0d\u56e0\u6cbb\u7642\u3001\u76e1\u65e9\u6cbb\u7642\u3001\u5168\u90e8\u6cbb\u7642\u3001\u9577\u671f\u6cbb\u7642\u300d\u7684<\/span>IgA<\/span>\u814e\u75c5\u65b0\u7ba1\u7406\u7b56\u7565\uff0c\u70ba<\/span>IgA<\/span>\u814e\u75c5\u7684\u5168\u65b9\u4f4d\u7ba1\u7406\u63d0\u4f9b\u6709\u529b\u8b49\u64da\u3002<\/span><\/p>\n

\u5831\u544a\u671f\u5f8c\u7684\u6210\u5c31\u53ca\u9810\u671f\u91cc\u7a0b\u7891\uff1a<\/span> <\/p>\n

– 2025<\/span>\u5e74<\/span>8<\/span>\u6708\uff0c\u516c\u53f8\u5ba3\u5e03\u5176\u4e2d\u570b\u9996\u500b\u4e14\u552f\u4e00\u7372\u5f97\u5b8c\u5168\u6279\u51c6\u7684<\/span>IgA<\/span>\u814e\u75c5\u5c0d\u56e0\u6cbb\u7642\u85e5\u7269\u8010\u8ce6\u5eb7\u00ae<\/span>\u64f4\u7522\u88dc\u5145\u7533\u8acb\u5df2\u6b63\u5f0f\u7372\u5f97\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u3002\u4f5c\u70ba\u5168\u7403\u9996\u500b\u4e14\u76ee\u524d\u552f\u4e00\u5728\u4e2d\u570b\u3001\u7f8e\u570b\u548c\u6b50\u6d32\u7372\u5f97\u5b8c\u5168\u6279\u51c6\u7684<\/span>IgA<\/span>\u814e\u75c5\u5c0d\u56e0\u6cbb\u7642\u85e5\u7269\uff0c\u6b64\u6b21\u64f4\u7522\u7372\u6279\u5c07\u9032\u4e00\u6b65\u63d0\u5347\u8010\u8ce6\u5eb7\u00ae<\/span>\u7522\u80fd\uff0c\u589e\u52a0\u7522\u54c1\u4f9b\u61c9\uff0c\u66f4\u9ad8\u6548\u5730\u56de\u61c9\u4e2d\u570b\u53ca\u4e9e\u6d32\u5730\u5340\u5c0d\u8010\u8ce6\u5eb7\u00ae<\/span>\u7684\u6301\u7e8c\u589e\u9577\u7684\u81e8\u5e8a\u9700\u6c42\u3002<\/span><\/p>\n

– 2025<\/span>\u5e74<\/span>8<\/span>\u6708\uff0c\u516c\u53f8\u5ba3\u5e03\u4e2d\u570b\u53f0\u7063\u5730\u5340\u85e5\u653f\u90e8\u9580\u5df2\u6b63\u5f0f\u6279\u51c6\u8010\u8ce6\u5eb7\u00ae<\/span>\u7684\u88dc\u5145\u7533\u8acb\u3002\u8010\u8ce6\u5eb7\u00ae<\/span>\u9069\u7528\u65bc\u7f79\u60a3\u539f\u767c\u6027\u514d\u75ab\u7403\u86cb\u767d<\/span>A<\/span>\u814e\u75c5\uff08<\/span>IgA<\/span>\u814e\u75c5\uff09\u4e14\u75c5\u60c5\u6709\u60e1\u5316\u98a8\u96aa\u7684\u6210\u4eba\u75c5\u4eba\uff0c\u7528\u4ee5\u6e1b\u7de9\u814e\u529f\u80fd\u4e0b\u964d\u3002\u6b64\u524d\uff0c\u8010\u8ce6\u5eb7\u00ae<\/span>\u5df2\u5728\u4e2d\u570b\u5927\u9678\u3001\u65b0\u52a0\u5761\u3001\u4e2d\u570b\u9999\u6e2f\u3001\u4e2d\u570b\u6fb3\u9580\u548c\u97d3\u570b\u7372\u5f97\u5b8c\u5168\u6279\u51c6\uff0c\u7528\u65bc\u6cbb\u7642\u7f79\u60a3\u539f\u767c\u6027\u514d\u75ab\u7403\u86cb\u767d<\/span>A<\/span>\u814e\u75c5\u8b8a\u7684\u6210\u4eba\u60a3\u8005\u3002\u81f3\u6b64\uff0c\u8010\u8ce6\u5eb7\u00ae<\/span>\u5df2\u5728\u96f2\u9802\u65b0\u8000\u8986\u84cb\u7684\u6240\u6709\u6388\u6b0a\u5340\u57df\u5be6\u73fe\u5b8c\u5168\u6279\u51c6\uff0c\u978f\u56fa\u4e86\u5176\u5728\u4e9e\u6d32\u4f5c\u70ba<\/span>IgA<\/span>\u814e\u75c5\u4e00\u7dda\u6cbb\u7642\u57fa\u77f3\u7684\u5730\u4f4d\uff0c\u63a8\u52d5<\/span>IgA<\/span>\u814e\u75c5\u6cbb\u7642\u7684\u6a19\u6e96\u5316\u8207\u898f\u7bc4\u5316\u9032\u7a0b\u3002<\/span><\/p>\n

– <\/span>\u516c\u53f8\u9810\u8a08\u8010\u8ce6\u5eb7\u00ae<\/span>\u4e0b\u534a\u5e74\u5c07\u88ab\u6b63\u5f0f\u7d0d\u5165\u6539\u5584\u5168\u7403\u9810\u5f8c\uff08<\/span>KDIGO<\/span>\uff09<\/span>2025<\/span>\u6307\u5357\uff0c\u4e26\u88ab\u7d0d\u5165\u4e2d\u570b\u9996\u500b<\/span>IgA<\/span>\u814e\u75c5\u8a3a\u7642\u6307\u5357\u3002<\/span><\/p>\n

EVER001<\/span>\uff08\u5e0c\u5e03\u66ff\u5c3c\uff09<\/span>\u662f\u65b0\u4e00\u4ee3\u5275\u65b0\u6027\u7684\u5171\u50f9\u53ef\u9006<\/span>BTK<\/span>\u6291\u5236\u5291\uff0c\u6f5b\u5728\u7528\u65bc\u6cbb\u7642\u5305\u62ec\u539f\u767c\u6027\u819c\u6027\u814e\u75c5\u3001<\/span>IgA<\/span>\u814e\u75c5\u3001\u5fae\u5c0f\u75c5\u8b8a\u6027\u814e\u75c5\u3001\u5c40\u7076\u7bc0\u6bb5\u6027\u814e\u5c0f\u7403\u786c\u5316\u548c\u72fc\u7621\u6027\u814e\u708e\u7b49\u814e\u81df\u75be\u75c5\u5728\u5167\u7684\u81ea\u8eab\u514d\u75ab\u6027\u814e\u75c5\u3002\u8207\u5171\u50f9\u4e0d\u53ef\u9006<\/span>BTK<\/span>\u6291\u5236\u5291\u76f8\u6bd4\uff0c<\/span>EVER001<\/span>\u4f5c\u70ba\u4e00\u6b3e\u6f5b\u5728\u7684\u540c\u985e\u6700\u4f73\u7522\u54c1\uff0c\u5728\u4fdd\u6301\u9ad8\u6d3b\u6027\u7684\u540c\u6642\u5177\u6709\u9ad8\u9078\u64c7\u6027\uff0c\u907f\u514d\u6301\u7e8c\u6291\u5236\u5e36\u4f86\u7684\u6bd2\u526f\u4f5c\u7528\u3002\u96f2\u9802\u65b0\u8000\u64c1\u6709\u9019\u6b3e\u7522\u54c1\u7528\u65bc\u814e\u75c5\u6cbb\u7642\u7684\u5168\u7403\u6b0a\u76ca\u3002<\/span><\/p>\n

– 2025<\/span>\u5e74<\/span>6<\/span>\u6708\uff0c\u96f2\u9802\u65b0\u8000\u5728\u7b2c<\/span>62<\/span>\u5c46\u6b50\u6d32\u814e\u81df\u5354\u6703<\/span>(ERA 2025)<\/span>\u5927\u6703\u4e0a\u516c\u5e03<\/span>EVER001<\/span>\u5728\u4e2d\u570b\u6b63\u5728\u9032\u884c\u4e2d\u7684<\/span>1b<\/span>\/2a<\/span>\u671f\u81e8\u5e8a\u8a66\u9a57\u7684\u7a4d\u6975\u7d50\u679c\uff0c\u5305\u62ec\u622a\u81f3<\/span>2024<\/span>\u5e74<\/span>12<\/span>\u6708<\/span>17<\/span>\u65e5\u6536\u96c6\u5230\u7684\u66f4\u591a\u60a3\u8005\u7684\u66f4\u9577\u671f\u6578\u64da\u3002\u5176\u4e2d\u4f4e\u5291\u91cf\u7d44<\/span>10<\/span>\u4f4d\u60a3\u8005\u96a8\u8a2a\u81f3<\/span>52<\/span>\u5468\uff0c\u9ad8\u5291\u91cf\u7d44<\/span>10<\/span>\u4f4d\u60a3\u8005\u5b8c\u6210\u4e86<\/span>24<\/span>\u5468\u6cbb\u7642\u3002\u76f8\u5c0d\u65bc\u57fa\u7dda\uff0c\u6297<\/span>-PLA2R<\/span>\u81ea\u8eab\u6297\u9ad4\u6700\u5c0f\u4e8c\u4e58\u6cd5<\/span>(LS)<\/span>\u5e7e\u4f55\u5e73\u5747\u503c\u5728<\/span>12<\/span>\u5468\u6642\u4f4e\u5291\u91cf\u7d44\u548c\u9ad8\u5291\u91cf\u7d44 \u5206\u5225\u4e0b\u964d<\/span>62.1%<\/span>\u548c<\/span>87.3%<\/span>\uff0c\u800c\u5728<\/span>24<\/span>\u5468\u6642\u5169\u7d44\u964d\u5e45\u5747\u589e\u81f3<\/span>93%<\/span>\u5de6\u53f3\u3002\u6b64\u5916\uff0c\u4f4e\u5291\u91cf\u7d44\u5728<\/span>36<\/span>\u5468\u86cb\u767d\u5c3f\u6c34\u5e73\u8f03\u57fa\u7dda\u4e0b\u964d<\/span>78.0%<\/span>\u4e26\u65bc\u505c\u85e5\u5f8c\u7dad\u6301\u5230\u7b2c<\/span>52<\/span>\u5468\uff1b\u9ad8\u5291\u91cf\u7d44\u5728<\/span>24<\/span>\u5468\u5373\u51fa\u73fe\u86cb\u767d\u5c3f<\/span>70.1%<\/span>\u7684\u4e0b\u964d\uff0c\u5176\u4e2d<\/span>80.0%<\/span>\u7684\u60a3\u8005\u5df2\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\u3002\u5169\u500b\u5291\u91cf\u7d44\u7684\u60a3\u8005\u5728\u6cbb\u7642\u671f\u9593\u5747\u4fdd\u6301\u4e86\u814e\u529f\u80fd\u7684\u7a69\u5b9a\u3002<\/span>EVER001<\/span>\u81e8\u5e8a\u7e3d\u9ad4\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u826f\u597d\uff0c\u672a\u89c0\u5bdf\u5230\u5728\u5176\u4ed6\u5171\u50f9\u975e\u53ef\u9006<\/span>BTK <\/span>\u6291\u5236\u5291\u4e0a\u5e38\u898b\u7684\u4e00\u4e9b\u6709\u81e8\u5e8a\u610f\u7fa9\u7684\u4e0d\u826f\u4e8b\u4ef6\u3002<\/span><\/p>\n

\u5831\u544a\u671f\u5f8c\u7684\u6210\u5c31\u53ca\u9810\u671f\u91cc\u7a0b\u7891\uff1a<\/span> <\/p>\n

– 2025<\/span>\u5e74<\/span>7<\/span>\u6708\uff0c\u96f2\u9802\u65b0\u8000\u5ba3\u5e03\u6b63\u5728\u9032\u884c\u4e2d\u7684<\/span>EVER001<\/span>\u7684<\/span>1b<\/span>\/2a<\/span>\u671f\u81e8\u5e8a\u8a66\u9a57\u6700\u65b0\u968e\u6bb5\u6027\u6578\u64da\u53d6\u5f97\u7a4d\u6975\u7d50\u679c\uff0c\u6536\u96c6\u5230\u7684\u6578\u64da\u622a\u81f3<\/span>2025<\/span>\u5e74<\/span>3<\/span>\u6708<\/span>21<\/span>\u65e5\uff0c\uff08\u4f4e\u5291\u91cf\u7d44<\/span>11<\/span>\u4f4d\u60a3\u8005\u96a8\u8a2a\u81f3<\/span>52<\/span>\u5468\uff0c\u9ad8\u5291\u91cf\u7d44\u5206\u5225\u6709<\/span>16<\/span>\u4f4d\u548c<\/span>12<\/span>\u4f4d\u60a3\u8005\u5b8c\u6210\u4e86<\/span>24<\/span>\u5468\u548c<\/span>36<\/span>\u5468\u6cbb\u7642\uff0c\u4e26\u6709<\/span>7<\/span>\u4f4d\u60a3\u8005\u96a8\u8a2a\u81f3<\/span>52<\/span>\u5468\uff09\u3002\u76f8\u5c0d\u65bc\u57fa\u7dda\uff0c\u6297<\/span>-PLA2R<\/span>\u81ea\u8eab\u6297\u9ad4\u6700\u5c0f\u4e8c\u4e58\u6cd5\uff08<\/span>LS<\/span>\uff09\u5e7e\u4f55\u5e73\u5747\u503c\u5728<\/span>12<\/span>\u5468\u6642\u4f4e\u5291\u91cf\u7d44\u548c\u9ad8\u5291\u91cf\u7d44\u5206\u5225\u4e0b\u964d<\/span>62.1%<\/span>\u548c<\/span>87.3%<\/span>\uff0c\u5728<\/span>24<\/span>\u5468\u6642\u5169\u7d44\u964d\u5e45\u5747\u589e\u81f3<\/span>93%<\/span>\u4ee5\u4e0a\uff0c\u4e26\u7dad\u6301\u5230\u7b2c<\/span>52<\/span>\u5468\u3002<\/span>24<\/span>\u5468\u6642\uff0c<\/span>76.9%<\/span>\u7684\u4f4e\u5291\u91cf\u7d44\u548c<\/span>88.2%<\/span>\u7684\u9ad8\u5291\u91cf\u7d44\u60a3\u8005\u5df2\u9054\u5230\u514d\u75ab\u5b78\u5b8c\u5168\u7de9\u89e3\u3002<\/span>24<\/span>\u5c0f\u6642\u86cb\u767d\u5c3f<\/span>LS<\/span>\u5e7e\u4f55\u5e73\u5747\u503c\uff0c\u5728<\/span>24<\/span>\u5468\u6642\u4f4e\u5291\u91cf\u7d44\u548c\u9ad8\u5291\u91cf\u7d44\u5206\u5225\u4e0b\u964d<\/span>57.0%<\/span>\u548c<\/span>67.6%<\/span>\uff0c<\/span>36<\/span>\u5468\u6642\u964d\u5e45\u5206\u5225\u589e\u81f3<\/span>76.7% <\/span>\u548c<\/span>80.6%<\/span>\uff0c\u4e26\u7dad\u6301\u5230\u7b2c<\/span>52<\/span>\u5468\u3002\u8207\u6b64\u524d\u89c0\u5bdf\u7d50\u679c\u4e00\u81f4\uff0c<\/span>24<\/span>\u5468\u6642\uff0c<\/span>38.5%<\/span>\u7684\u4f4e\u5291\u91cf\u7d44\u60a3\u8005\u548c<\/span>70.6%<\/span>\u7684\u9ad8\u5291\u91cf\u7d44\u60a3\u8005\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\uff0c\u800c\u5728<\/span>36<\/span>\u5468\u6642\u9019\u4e00\u6bd4\u4f8b\u9032\u4e00\u6b65\u4e0a\u5347\u81f3<\/span>69.2%<\/span>\u548c<\/span>91.7%<\/span>\u3002\u5169\u500b\u5291\u91cf\u7d44\u7684\u60a3\u8005\u5728\u6cbb\u7642\u671f\u9593\u7684\u5e73\u5747\u8840\u6e05\u767d\u86cb\u767d\u6c34\u5e73\u5747\u9054\u5230\u4e86\u6b63\u5e38\u7bc4\u570d\uff0c\u540c\u6642\u4fdd\u6301\u4e86\u814e\u529f\u80fd\u7684\u7a69\u5b9a\u3002\u7e3d\u9ad4\u800c\u8a00\uff0c<\/span>EVER00<\/span>\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u826f\u597d\uff0c\u8207\u6b64\u524d\u89c0\u5bdf\u7d50\u679c\u4e00\u81f4\u3002\u7d55\u5927\u90e8\u5206\u5831\u544a\u7684\u4e0d\u826f\u4e8b\u4ef6\u5747\u70ba<\/span>1<\/span>\u7d1a\u6216<\/span>2<\/span>\u7d1a\uff0c\u672a\u89c0\u5bdf\u5230\u5728\u5176\u4ed6\u5171\u50f9\u975e\u53ef\u9006<\/span>BTK<\/span>\u6291\u5236\u5291\u4e0a\u5e38\u898b\u7684\u6709\u81e8\u5e8a\u610f\u7fa9\u7684\u4e0d\u826f\u4e8b\u4ef6\u3002<\/span><\/p>\n

– <\/span>\u516c\u53f8\u9810\u8a08\u5728<\/span>9<\/span>\u6708\u516c\u5e03<\/span>EVER001 1b<\/span>\/2a<\/span>\u671f\u81e8\u5e8a\u8a66\u9a57\u7684\u4e00\u5e74\u96a8\u8a2a\u6578\u64da\u3002<\/span><\/p>\n

\u611f\u67d3\u6027\u75be\u75c5\u7ba1\u7dda<\/span><\/p>\n

\u4f9d\u5609\u00ae<\/span>\uff08\u4f9d\u62c9\u74b0\u7d20\uff09<\/span><\/p>\n

– 2025<\/span>\u5e74<\/span>6<\/span>\u6708\uff0c\u300a\u4e2d\u83ef\u6aa2\u9a57\u91ab\u5b78\u96dc\u8a8c\u300b\u6b63\u5f0f\u767c\u8868\u300a\u4f9d\u62c9\u74b0\u7d20\u9ad4\u5916\u85e5\u7269\u654f\u611f\u6027\u8a66\u9a57\u898f\u7bc4\uff08<\/span>2025<\/span>\uff09\u300b\uff0c\u70ba\u898f\u7bc4\u958b\u5c55\u4f9d\u62c9\u74b0\u7d20\u9ad4\u5916\u85e5\u654f\u8a66\u9a57\u548c\u7d50\u679c\u89e3\u8b80\u63d0\u4f9b\u53c3\u8003\uff0c\u4ee5\u671f\u300c\u6709\u64da\u53ef\u4f9d\u300d\u5730\u6307\u5c0e\u81e8\u5e8a\u5408\u7406\u7528\u85e5<\/span>; <\/span>\u540c\u6642\u4e5f\u6709\u52a9\u65bc\u4fc3\u9032\u81e8\u5e8a\u5fae\u751f\u7269\u5b78\u5be6\u9a57\u5ba4\u5c0d\u4f9d\u62c9\u74b0\u7d20\u85e5\u654f\u8a66\u9a57\u4f5c\u65b9\u6cd5\u7684\u898f\u8303\u6027\u548c\u7d50\u679c\u5831\u544a\u7684\u6e96\u78ba\u6027\uff0c\u300c\u6709\u4f9d\u53ef\u9760\u300d\u5730\u652f\u6301\u4f9d\u62c9\u74b0\u7d20\u61c9\u5c0d\u81e8\u5e8a\u591a\u91cd\u8010\u85e5\u83cc\u611f\u67d3\u548c\u5fa9\u96dc\u611f\u67d3\u7684\u6311\u6230\u3002\u8a72\u898f\u7bc4\u7531\u570b\u5bb6\u885b\u751f\u5065\u5eb7\u59d4\u81e8\u5e8a\u6297\u5fae\u751f\u7269\u85e5\u7269\u654f\u611f\u6027\u6298\u9ede\u7814\u7a76\u548c\u6a19\u6e96\u5236\u5b9a\u5c08\u5bb6\u59d4\u54e1\u6703\uff08<\/span>ChinaCAST<\/span>\uff09\u3001\u4e2d\u570b\u91ab\u9662\u5354\u6703\u81e8\u5e8a\u5fae\u751f\u7269\u5be6\u9a57\u5ba4\u5c08\u696d\u59d4\u54e1\u6703\u3001\u6b50\u6d32\u81e8\u5e8a\u5fae\u751f\u7269\u8207\u611f\u67d3\u75c5\u5b78\u6703\u85e5\u654f\u59d4\u54e1\u6703\u83ef\u4eba\u85e5\u654f\u8a66\u9a57\u59d4\u54e1\u6703\u5171\u540c\u5236\u5b9a\u3002\u6b64\u6b21\u767c\u5e03\u7684\u898f\u7bc4\u8207<\/span>2024<\/span>\u5e74<\/span>ChinaCAST<\/span>\u767c\u5e03\u7684\u4f9d\u62c9\u74b0\u7d20\u4e2d\u570b\u81e8\u5e8a\u6298\u9ede\u76f8\u8f14\u76f8\u6210\uff0c\u5f62\u6210\u300c\u5c3a\u898f\u5408\u4e00\u300d\u7684\u5b8c\u6574\u6280\u8853\u9ad4\u7cfb\u3002<\/span><\/p>\n

\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7ba1\u7dda<\/span><\/p>\n

\u827e\u66f2\u83ab\u5fb7\uff08<\/span>VELSIPITY\u00ae<\/span>\uff0c<\/span>etrasimod<\/span>\uff09<\/span><\/p>\n

– 2025<\/span>\u5e74<\/span>2<\/span>\u6708\uff0c\u827e\u66f2\u83ab\u5fb7\u7684\u4e9e\u6d32\u591a\u4e2d\u5fc3<\/span>III<\/span>\u671f\u81e8\u5e8a\u7814\u7a76\u7684\u5b8c\u6574\u7dad\u6301\u671f\u6578\u64da\uff0c\u5728\u7b2c<\/span>20<\/span>\u5c46\u6b50\u6d32\u514b\u7f85\u6069\u75c5\u548c\u7d50\u8178\u708e\u7d44\u7e54\u5927\u6703\uff08<\/span>ECCO 2025<\/span>\uff09\u4e0a\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u516c\u5e03\u3002\u827e\u66f2\u83ab\u5fb7\u662f\u8fc4\u4eca\u70ba\u6b62\u5728\u4e9e\u6d32\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027<\/span>UC<\/span>\u4eba\u7fa4\u4e2d\u552f\u4e00\u5b8c\u6210\u5927\u6a23\u672c\u96a8\u6a5f\u5c0d\u7167\u95dc\u9375\u6027\u7814\u7a76\u7684<\/span>UC<\/span>\u5148\u9032\u7642\u6cd5\u3002<\/span>ES101002<\/span>\u7814\u7a76\u7d50\u679c\u70ba\u827e\u66f2\u83ab\u5fb7\u5728\u4e9e\u6d32\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027<\/span>UC<\/span>\u60a3\u8005\u4e2d\u7684\u61c9\u7528\u63d0\u4f9b\u4e86\u5f37\u6709\u529b\u7684\u8b49\u64da\u652f\u6301\u3002\u6578\u64da\u8b49\u5be6\uff0c\u7d93\u904e<\/span>40<\/span>\u5468\u4ee5<\/span>2mg<\/span>\u5291\u91cf\u7684\u7dad\u6301\u6cbb\u7642\u5f8c\uff0c\u827e\u66f2\u83ab\u5fb7\u7d44\u5177\u6709\u986f\u8457\u7684\u81e8\u5e8a\u548c\u5167\u93e1\u5b78\u65b9\u9762\u7684\u7372\u76ca\uff0c\u5305\u62ec\u9ecf\u819c\u6108\u5408\u3001\u5167\u93e1\u6062\u5fa9\u6b63\u5e38\u548c\u7d44\u7e54\u5b78\u6539\u5584\u3002\u827e\u66f2\u83ab\u5fb7\u5b89\u5168\u6027\u6578\u64da\u8207\u5df2\u77e5\u7279\u5fb5\u4e00\u81f4\uff0c\u6c92\u6709\u89c0\u5bdf\u5230\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002<\/span><\/p>\n

– 2025<\/span>\u5e74<\/span>3<\/span>\u6708\uff0c\u827e\u66f2\u83ab\u5fb7\u4f4d\u65bc\u5609\u5584\u5de5\u5ee0\u7684\u751f\u7522\u5efa\u8a2d\u9805\u76ee\u6b63\u5f0f\u555f\u52d5\u3002\u8a72\u9805\u76ee\u7e3d\u6295\u8cc7\u70ba<\/span>7000<\/span>\u842c\u5143\uff0c\u9810\u8a08\u6b63\u5f0f\u6295\u7522\u5f8c\u827e\u66f2\u83ab\u5fb7\u7684\u5e74\u7522\u80fd\u53ef\u9054<\/span>5000<\/span>\u842c\u7247\uff0c\u8a08\u5283\u4f9b\u61c9\u5730\u5340\u8986\u84cb\u5305\u62ec\u4e2d\u570b\u5927\u9678\u3001\u4e2d\u570b\u9999\u6e2f\u3001\u4e2d\u570b\u6fb3\u9580\u3001\u4e2d\u570b\u53f0\u7063\u3001\u97d3\u570b\u4ee5\u53ca\u65b0\u52a0\u5761\u5728\u5167\u7684\u96f2\u9802\u65b0\u8000\u6388\u6b0a\u5340\u57df\u3002<\/span><\/p>\n

– 2025<\/span>\u5e74<\/span>4<\/span>\u6708\uff0c\u4e2d\u570b\u9999\u6e2f\u885b\u751f\u7f72\u6b63\u5f0f\u6279\u51c6\u827e\u66f2\u83ab\u5fb7\u7528\u65bc\u6cbb\u7642\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\uff08<\/span>UC<\/span>\uff09\u6210\u4eba\u60a3\u8005\u7684\u65b0\u85e5\u4e0a\u5e02\u8a31\u53ef\u7533\u8acb\u3002<\/span><\/p>\n

– 2025<\/span>\u5e74<\/span>6<\/span>\u6708\uff0c\u97d3\u570b\u98df\u54c1\u85e5\u54c1\u5b89\u5168\u90e8\uff08<\/span>MFDS<\/span>\uff09\u6b63\u5f0f\u53d7\u7406\u827e\u66f2\u83ab\u5fb7\u7528\u65bc\u6cbb\u7642\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\uff08<\/span>UC<\/span>\uff09\u60a3\u8005\u7684\u65b0\u85e5\u4e0a\u5e02\u8a31\u53ef\u7533\u8acb\uff08<\/span>NDA<\/span>\uff09\u3002<\/span><\/p>\n

– 2025<\/span>\u5e74<\/span>6<\/span>\u6708\uff0c\u827e\u66f2\u83ab\u5fb7\u88ab\u7d0d\u5165\u300a<\/span>2025 ACG <\/span>\u81e8\u5e8a\u6307\u5357\uff1a\u6210\u4eba\u6f70\u760d\u6027\u7d50\u8178\u708e\u300b\u3002\u65b0\u7248\u6307\u5357\u5f37\u70c8\u63a8\u85a6\u5c07\u827e\u66f2\u83ab\u5fb7\u7528\u65bc\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\u60a3\u8005\u7684\u8a98\u5c0e\u7de9\u89e3\u6cbb\u7642\uff08\u4e2d\u7b49\u8cea\u91cf\u8b49\u64da\uff09\uff0c\u4e26\u63a8\u85a6\u5728\u7d93\u9798\u6c28\u9187<\/span>-1 –<\/span>\u78f7\u9178<\/span> (S1P) <\/span>\u53d7\u9ad4\u8abf\u7bc0\u5291\u8a98\u5c0e\u7de9\u89e3\u5f8c\u7e7c\u7e8c\u4f7f\u7528\u827e\u66f2\u83ab\u5fb7\u4ee5\u7dad\u6301\u7de9\u89e3\uff08\u5f37\u70c8\u63a8\u85a6\uff0c\u4e2d\u7b49\u8cea\u91cf\u8b49\u64da\uff09\u3002\u9019\u4e00\u91cd\u8981\u9032\u5c55\u4e0d\u50c5\u9ad4\u73fe\u4e86\u570b\u969b\u6b0a\u5a01\u91ab\u5b78\u6307\u5357\u5c0d\u827e\u66f2\u83ab\u5fb7\u81e8\u5e8a\u50f9\u503c\u7684\u9ad8\u5ea6\u8a8d\u53ef\uff0c\u4e5f\u9032\u4e00\u6b65\u5f70\u986f\u4e86\u5176\u5728\u6eff\u8db3<\/span>UC<\/span>\u60a3\u8005\u672a\u88ab\u6eff\u8db3\u7684\u6cbb\u7642\u9700\u6c42\u65b9\u9762\u7684\u6f5b\u529b\uff0c\u70ba\u5168\u7403<\/span>UC<\/span>\u60a3\u8005\u63d0\u4f9b\u65b0\u7684\u6cbb\u7642\u9078\u64c7\u3002<\/span><\/p>\n

\u5831\u544a\u671f\u5f8c\u7684\u6210\u5c31\u53ca\u9810\u671f\u91cc\u7a0b\u7891\uff1a<\/span> <\/p>\n

– 2025<\/span>\u5e74<\/span>7<\/span>\u6708\uff0c\u827e\u66f2\u83ab\u5fb7\u6cbb\u7642\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\uff08<\/span>UC<\/span>\uff09\u60a3\u8005\u7684\u5168\u7403<\/span>4<\/span>\u5e74\u5b89\u5168\u6027\u96a8\u8a2a\u6578\u64da\u5728\u7b2c<\/span>13<\/span>\u5c46\u4e9e\u6d32\u708e\u75c7\u6027\u8178\u75c5\u5354\u6703\uff08<\/span>AOCC 2025<\/span>\uff09\u5e74\u6703\u4e0a\u516c\u5e03\u3002\u9019\u4e9b\u6578\u64da\u4e4b\u524d\u5df2\u5728\u6b50\u6d32\u514b\u7f85\u6069\u75c5\u548c\u7d50\u8178\u708e\u7d44\u7e54<\/span>(ECCO)<\/span>\u5927\u6703\u53ca\u6d88\u5316\u75be\u75c5\u5468<\/span>(DDW)<\/span>\u6703\u8b70\u4e0a\u516c\u5e03\u3002\u6578\u64da\u986f\u793a\uff0c\u827e\u66f2\u83ab\u5fb7\u9577\u671f\u6cbb\u7642\u4ecd\u80fd\u4fdd\u6301\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u5176\u826f\u597d\u7684\u5b89\u5168\u6027\u7279\u5fb5\u5728\u9577\u671f\u6cbb\u7642\u671f\u9593\u672a\u767c\u751f\u6539\u8b8a\u3002<\/span><\/p>\n

– 2025<\/span>\u5e74<\/span>8<\/span>\u6708\uff0c\u4e2d\u570b\u53f0\u7063\u885b\u751f\u798f\u5229\u90e8<\/span>(TFDA)<\/span>\u6b63\u5f0f\u53d7\u7406\u827e\u66f2\u83ab\u5fb7\u7528\u65bc\u6cbb\u7642\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\u60a3\u8005\u7684\u65b0\u85e5\u4e0a\u5e02\u8a31\u53ef\u7533\u8acb\u3002\u827e\u66f2\u83ab\u5fb7\u7372\u97d3\u570b\u548c\u4e2d\u570b\u53f0\u7063\u53d7\u7406\uff0c\u6a19\u5fd7\u8457\u7e7c\u4e2d\u570b\u6fb3\u9580\u3001\u65b0\u52a0\u5761\u548c\u4e2d\u570b\u9999\u6e2f\u7372\u6279\u4e4b\u5f8c\uff0c\u5176\u5728\u4e9e\u6d32\u5e02\u5834\u7684\u51c6\u5165\u53d6\u5f97\u91cd\u8981\u9032\u5c55\u3002<\/span><\/p>\n

– <\/span>\u516c\u53f8\u9810\u8a08\u827e\u66f2\u83ab\u5fb7\u5c07\u65bc<\/span>2026<\/span>\u5e74\u4e0a\u534a\u5e74\u5728\u4e2d\u570b\u5927\u9678\u7372\u5f97\u65b0\u85e5\u4e0a\u5e02\u6279\u51c6\u3002<\/span><\/p>\n

mRNA<\/span>\u6280\u8853\u5e73\u53f0<\/span><\/p>\n

\u96f2\u9802\u65b0\u8000\u5df2\u69cb\u5efa\u696d\u5167\u9818\u5148\u7684\u3001\u5b8c\u5168\u6574\u5408\u4e14\u672c\u5730\u5316\u7684<\/span>AI+mRNA<\/span>\u5e73\u53f0\uff0c\u4e26\u5728\u6b64\u57fa\u790e\u4e0a\u591a\u8def\u5f91\u63a8\u9032<\/span>mRNA<\/span>\u816b\u7624\u6cbb\u7642\u6027\u75ab\u82d7\u548c\u81ea\u9ad4\u751f\u6210<\/span>CAR-T<\/span>\u5e73\u53f0\uff0c\u6cbb\u7642\u816b\u7624\u53ca\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u3002<\/span><\/p>\n

EVM16<\/span>\u57fa\u65bc<\/span>AI<\/span>\u9a45\u52d5\u7684\u7b2c\u4e09\u4ee3\u300c\u5999\u7b97\u300d\u65b0\u6297\u539f\u7b97\u6cd5\uff0c\u91dd\u5c0d\u60a3\u8005\u7279\u7570\u6027\u7a81\u8b8a\u8a2d\u8a08<\/span>mRNA<\/span>\u5e8f\u5217\uff0c\u901a\u904e<\/span>LNP<\/span>\u905e\u9001\u555f\u52d5<\/span>T<\/span>\u7d30\u80de\u514d\u75ab\uff0c\u5df2\u5728\u5c0f\u9f20\u9ed1\u8272\u7d20\u7624\u6a21\u578b\u4e2d\u9a57\u8b49\u7642\u6548\u4e26\u5c55\u73fe\u8207<\/span>PD-1<\/span>\u6297\u9ad4\u806f\u7528\u5177\u6709\u5354\u540c\u4f5c\u7528\u3002<\/span>EVM14<\/span>\u9776\u5411<\/span>5<\/span>\u7a2e\u816b\u7624\u76f8\u95dc\u6297\u539f\uff0c\u9069\u7528\u65bc\u591a\u7a2e\u9c57\u764c\uff0c\u81e8\u5e8a\u524d\u7814\u7a76\u767c\u73fe\u5176\u5177\u5099\u8a98\u5c0e\u514d\u75ab\u8a18\u61b6\u3001\u964d\u4f4e\u816b\u7624\u5fa9\u767c\u7684\u6f5b\u529b\u3002\u76ee\u524d<\/span>EVM14<\/span>\u7684\u7f8e\u570b<\/span>IND<\/span>\u7533\u8acb\u5df2\u7372<\/span>FDA<\/span>\u6279\u51c6\uff0c\u4e2d\u570b<\/span>IND<\/span>\u7533\u8acb\u5df2\u7372<\/span>CDE<\/span>\u53d7\u7406\u3002\u514d\u75ab\u8abf\u7bc0\u816b\u7624\u75ab\u82d7<\/span>EVM15<\/span>\u7684\u81e8\u5e8a\u524d\u7814\u7a76\u6b63\u5728\u9032\u884c\u4e2d\uff0c\u9810\u8a08<\/span>2025<\/span>\u5e74\u5167\u53d6\u5f97\u81e8\u5e8a\u524d\u6982\u5ff5\u9a57\u8b49\u3002<\/span><\/p>\n

\u81ea\u9ad4\u751f\u6210<\/span>CAR-T<\/span>\u5e73\u53f0\u4e5f\u5df2\u5728\u4eba\u6e90\u5316\u5c0f\u9f20\u8207\u975e\u4eba\u9748\u9577\u985e\uff08\u7334\uff09\u6a21\u578b\u4e2d\u9a57\u8b49\u6709\u6548\uff0c\u76f8\u8f03\u50b3\u7d71<\/span>CAR-T<\/span>\u7642\u6cd5\u5177\u5099\u73fe\u8ca8\u578b\u3001\u7121\u9700\u6dcb\u5df4\u8017\u7aed\u3001\u5291\u91cf\u53ef\u63a7\u7b49\u512a\u52e2\uff0c\u5c55\u73fe\u4e86\u958b\u767c\u7528\u65bc\u816b\u7624\u53ca\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u7684\u6f5b\u529b\uff0c\u9ad4\u73fe\u516c\u53f8\u5f9e\u300c\u6388\u6b0a\u5f15\u9032\u300d\u5411\u300c\u81ea\u4e3b\u5275\u65b0\u300d\u7684\u8f49\u578b\u5347\u7d1a\u3002<\/span><\/p>\n

– 2025<\/span>\u5e74<\/span>3<\/span>\u6708\uff0c\u516c\u53f8\u5ba3\u5e03\u81ea\u4e3b\u7814\u767c\u7684\u9996\u6b3e\u65b0\u578b<\/span>mRNA<\/span>\u500b\u6027\u5316\u816b\u7624\u6cbb\u7642\u6027\u75ab\u82d7<\/span>EVM16<\/span>\u5df2\u5728\u5317\u4eac\u5927\u5b78\u816b\u7624\u91ab\u9662\u9806\u5229\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u7d66\u85e5\uff0c\u6a19\u8a8c\u8457\u6b64\u9805\u81e8\u5e8a\u8a66\u9a57\u9805\u76ee\u7684\u91cc\u7a0b\u7891\u9032\u5c55\u3002\u81e8\u5e8a\u8a66\u9a57\u9805\u76ee<\/span>EVM16CX01<\/span>\u662f<\/span>EVM16<\/span>\u958b\u5c55\u7684\u9996\u6b21\u4eba\u9ad4\u8a66\u9a57\uff0c\u7531\u5317\u4eac\u5927\u5b78\u816b\u7624\u91ab\u9662\u548c\u5fa9\u65e6\u5927\u5b78\u9644\u5c6c\u816b\u7624\u91ab\u9662\u767c\u8d77\uff0c\u7528\u65bc\u8a55\u4f30<\/span>EVM16<\/span>\u6ce8\u5c04\u6db2\u55ae\u85e5\u53ca\u806f\u5408<\/span>PD-1<\/span>\u6297\u9ad4\u6cbb\u7642\u5728\u665a\u671f\u6216\u5fa9\u767c\u5be6\u9ad4\u7624\u53d7\u8a66\u8005\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u514d\u75ab\u539f\u6027\u548c\u521d\u6b65\u7642\u6548\u7684\u5291\u91cf\u905e\u589e\u53ca\u64f4\u5c55\u7814\u7a76\u3002<\/span><\/p>\n

– 2025<\/span>\u5e74<\/span>3<\/span>\u6708\uff0c\u516c\u53f8\u5ba3\u5e03\u5176\u901a\u7528\u578b\u7684\u73fe\u8ca8\u816b\u7624\u6cbb\u7642\u6027\u75ab\u82d7<\/span>EVM14<\/span>\u6ce8\u5c04\u6db2\u7684\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\u7533\u8acb\uff08<\/span>IND<\/span>\uff09\u7372\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u76e3\u7763\u7ba1\u7406\u5c40\uff08<\/span>FDA<\/span>\uff09\u7684\u6279\u51c6\u3002<\/span>EVM14<\/span>\u6ce8\u5c04\u6db2\u662f\u57fa\u65bc\u96f2\u9802\u65b0\u8000\u81ea\u4e3b\u77e5\u8b58\u7522\u6b0a\u7684<\/span>mRNA<\/span>\u6280\u8853\u5e73\u53f0\u7814\u767c\u3002\u4f5c\u70ba\u516c\u53f8\u9996\u500b\u7372\u5f97<\/span>FDA IND<\/span>\u6279\u51c6\u7684\u81ea\u4e3b\u7814\u767c\u65b0\u85e5\uff0c<\/span>EVM14<\/span>\u6a19\u8a8c\u8457\u516c\u53f8\u5728<\/span>mRNA<\/span>\u816b\u7624\u9818\u57df\u7684\u5275\u65b0\u5be6\u529b\u7372\u5f97\u570b\u969b\u6b0a\u5a01\u6a5f\u69cb\u7684\u8a8d\u53ef\uff0c\u662f\u516c\u53f8\u81ea\u4e3b\u7814\u767c\u6b77\u7a0b\u4e2d\u7684\u91cd\u8981\u91cc\u7a0b\u7891\u3002<\/span><\/p>\n

– 2025<\/span>\u5e74<\/span>6<\/span>\u6708\uff0c\u516c\u53f8\u5ba3\u5e03\u5176\u4f4d\u65bc\u4e2d\u570b\u6d59\u6c5f\u7701\u7684\u5609\u5584\u5de5\u5ee0\u5df2\u9806\u5229\u5b8c\u6210\u901a\u7528\u578b\u7684\u73fe\u8ca8\u816b\u7624\u6cbb\u7642\u6027\u75ab\u82d7<\/span>EVM14<\/span>\u9805\u76ee\u9996\u6279\u81e8\u5e8a\u6a23\u54c1\u7684\u653e\u884c\u3002\u8a72\u6279\u6a23\u54c1\u5c07\u7528\u65bc\u652f\u6301\u96f2\u9802\u65b0\u8000\u5728\u4e2d\u7f8e\u5169\u5730\u958b\u5c55<\/span>EVM14<\/span>\u7684\u81e8\u5e8a\u8a66\u9a57\u3002<\/span><\/p>\n

– 2025<\/span>\u5e74<\/span>6<\/span>\u6708\uff0c\u516c\u53f8\u6210\u529f\u5728\u4e0a\u6d77\u8209\u8fa6\u300c<\/span>2025<\/span>\u96f2\u9802\u65b0\u8000<\/span>mRNA<\/span>\u5275\u65b0\u6280\u8853\u5e73\u53f0\u7814\u767c\u65e5\u300d\uff0c\u7cfb\u7d71\u96c6\u4e2d\u5c55\u793a\u4e86\u96f2\u9802\u65b0\u8000\u81ea\u4e3b\u7814\u767c\u7684<\/span>AI+mRNA<\/span>\u6280\u8853\u5e73\u53f0\u7684\u6700\u65b0\u9032\u5c55\uff0c\u4ee5\u53ca\u57fa\u65bc\u8a72\u5e73\u53f0\u958b\u767c\u7684\u816b\u7624\u53ca\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u9818\u57df\u6838\u5fc3\u7ba1\u7dda\uff0c\u6a19\u8a8c\u8457\u300c\u96d9\u8f2a\u9a45\u52d5\u300d\u6230\u7565\u7684\u9032\u4e00\u6b65\u6df1\u5316\u8207\u5347\u7d1a\u3002<\/span><\/p>\n

\u5831\u544a\u671f\u5f8c\u7684\u6210\u5c31\u53ca\u9810\u671f\u91cc\u7a0b\u7891\uff1a<\/span> <\/p>\n

– 2025<\/span>\u5e74<\/span>7<\/span>\u6708\uff0c<\/span>EVM14<\/span>\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\u7533\u8acb\u5df2\u6b63\u5f0f\u7372\u5f97\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3<\/span>(CDE)<\/span>\u53d7\u7406\u3002<\/span><\/p>\n

– <\/span>\u516c\u53f8\u9810\u8a08\u5c07\u65bc<\/span>2025<\/span>\u5e74\u4e0b\u534a\u5e74\u5728\u7f8e\u570b\u5b8c\u6210<\/span>EVM14<\/span>\u9805\u76ee\u9996\u4f8b\u60a3\u8005\u5165\u7d44\u3002<\/span><\/p>\n

– <\/span>\u516c\u53f8\u9810\u8a08<\/span>EVM14<\/span>\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\u7533\u8acb\u5c07\u65bc<\/span>2025<\/span>\u5e74\u4e0b\u534a\u5e74\u7372\u5f97\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u3002<\/span><\/p>\n

– <\/span>\u516c\u53f8\u9810\u8a08<\/span>mRNA<\/span>\u6280\u8853\u5e73\u53f0\u81ea\u9ad4\u751f\u6210<\/span>CAR-T<\/span>\u9805\u76ee\u5c07\u65bc<\/span>2025<\/span>\u5e74\u4e0b\u534a\u5e74\u5b8c\u6210\u81e8\u5e8a\u524d\u5019\u9078\u85e5\u7269\u91cc\u7a0b\u7891\u3002<\/span><\/p>\n

– <\/span>\u516c\u53f8\u9810\u8a08<\/span>EVM16 <\/span>\u7814\u7a76\u8005\u767c\u8d77\u7684\u81e8\u5e8a\u8a66\u9a57<\/span>(IIT) <\/span>\u7814\u7a76\u5c07\u65bc<\/span>2025<\/span>\u5e74\u4e0b\u534a\u5e74\u5b8c\u6210\u60a3\u8005\u5165\u7d44\u3002<\/span><\/p>\n

\u5546\u696d\u5316\u9032\u5c55<\/span><\/p>\n

\u6211\u5011\u7684\u5546\u696d\u5316\u7522\u54c1\u7d44\u5408\u5df2\u6db5\u84cb\u75be\u75c5\u9996\u5275<\/span>IgA<\/span>\u814e\u75c5\u85e5\u7269\u8010\u8ce6\u5eb7\u00ae<\/span>\u3001\u9ad8\u7aef\u6297\u83cc\u85e5\u7269\u4f9d\u5609\u00ae<\/span>\u548c\u6f70\u760d\u6027\u7d50\u8178\u708e\u4e00\u7dda\u5148\u9032\u6cbb\u7642\u85e5\u7269\u7dad\u9069\u5e73\u00ae<\/span>\u4e09\u6b3e\u5177\u6709\u5f37\u52c1\u6536\u5165\u589e\u9577\u6f5b\u529b\u53ca\u5177\u6709\u7368\u7279\u5e02\u5834\u6230\u7565\u6027\u5b9a\u4f4d\u7684\u7522\u54c1\u3002<\/span>2025<\/span>\u5e74\u4e0a\u534a\u5e74\uff0c\u8010\u8ce6\u5eb7\u00ae<\/span>\u548c\u4f9d\u5609\u00ae<\/span>\u5169\u6b3e\u7522\u54c1\u53d6\u5f97<\/span>4.46<\/span>\u5104\u5143\u4eba\u6c11\u5e63\u7684\u92b7\u552e\u6536\u5165\u3002<\/span><\/p>\n

\u96a8\u8457\u8010\u8ce6\u5eb7\u00ae<\/span>\u65bc<\/span>2025<\/span>\u5e74<\/span>1<\/span>\u6708<\/span>1<\/span>\u65e5\u6b63\u5f0f\u7d0d\u5165\u300a\u570b\u5bb6\u91ab\u4fdd\u85e5\u54c1\u76ee\u9304\u300b\u4e26\u751f\u6548\uff0c\u5176\u4e0a\u534a\u5e74\u92b7\u552e\u6536\u5165\u5448\u5feb\u901f\u589e\u9577\u3002\u9019\u4e00\u589e\u9577\u4e3b\u8981\u5f97\u76ca\u65bc\u6838\u5fc3\u91ab\u9662\u8986\u84cb\u7bc4\u570d\u7684\u64f4\u5927\uff0c\u76ee\u524d\u5df2\u8986\u84cb<\/span>800<\/span>\u5bb6\u91ab\u9662\uff0c\u4f54\u5e02\u5834\u6f5b\u529b\u7684<\/span>80%<\/span>\u4ee5\u4e0a\uff0c\u6211\u5011\u7684\u5c08\u696d\u814e\u79d1\u92b7\u552e\u5718\u968a\u589e\u52a0\u5230\u4e86\u7d04<\/span>160<\/span>\u4eba\u3002\u901a\u904e\u91ab\u9662\u6b63\u5f0f\u51c6\u5165\u6216\u96d9\u901a\u9053\u85e5\u623f\u6a21\u5f0f\uff0c\u6211\u5011\u5feb\u901f\u63a8\u9032\u76ee\u6a19\u91ab\u9662\u5b8c\u6210\u91ab\u4fdd\u843d\u5730\uff0c\u622a\u81f3<\/span>6<\/span>\u6708\u5e95\u5df2\u6709\u7d04<\/span>80%<\/span>\u7684\u6838\u5fc3\u91ab\u9662\u5b8c\u6210\u8010\u8ce6\u5eb7\u00ae<\/span>\u91ab\u4fdd\u50f9\u683c\u8986\u84cb\u3002\u5728\u5404\u90e8\u9580\u7684\u52aa\u529b\u4e0b\uff0c\u4e0a\u534a\u5e74\u60a3\u8005\u6578\u91cf\u6fc0\u589e\uff0c\u7d2f\u8a08\u65b0\u589e\u60a3\u8005\u8d85\u904e<\/span>2<\/span>\u842c\u4eba\u3002<\/span><\/p>\n

\u91dd\u5c0d\u8010\u8ce6\u5eb7\u00ae<\/span>\u81e8\u5e8a\u50f9\u503c\u7684\u652f\u6301\u8b49\u64da\u6b63\u4e0d\u65b7\u7d2f\u7a4d\u3002\u4eca\u5e74\u4e0a\u534a\u5e74\uff0c\u8010\u8ce6\u5eb7\u00ae<\/span>\u88ab\u7d0d\u5165\u300a\u4e2d\u570b\u6210\u4eba<\/span>IgA<\/span>\u814e\u75c5\u53ca<\/span>IgA<\/span>\u8840\u7ba1\u708e\u81e8\u5e8a\u5be6\u8e10\u6307\u5357\uff08\u9810\u5be9\u7248\u672c\uff09\u300b\uff0c\u63a8\u85a6\u5c0d\u6709\u75be\u75c5\u9032\u5c55\u98a8\u96aa\u7684<\/span>IgA<\/span>\u814e\u75c5\u60a3\u8005\u9032\u884c<\/span>9<\/span>\u500b\u6708\u7684\u5e03\u5730\u5948\u5fb7\u8178\u6eb6\u81a0\u56ca\u5c0d\u56e0\u6cbb\u7642\uff0c\u4e0d\u53d7\u86cb\u767d\u5c3f\u6c34\u5e73\u7684\u9650\u5236\uff0c\u4ee5\u964d\u4f4e\u81f4\u75c5\u6027<\/span>IgA<\/span>\uff08<\/span>Gd-IgA1)<\/span>\uff1b\u6307\u5357\u9996\u6b21\u63d0\u51fa\u91dd\u5c0d\u514d\u75ab\u6027\u640d\u50b7\u9032\u884c\u5e72\u9810\uff0c\u5305\u62ec\u63a1\u53d6\u6e1b\u5c11\u81f4\u75c5\u6027<\/span>IgA<\/span>\u7b49\u6cbb\u7642\uff0c\u800c\u8010\u8ce6\u5eb7\u00ae<\/span>\u662f\u5c0d\u56e0\u6cbb\u7642\u7684\u9996\u9078\u3002\u9054\u5230\u77ed\u671f\u6cbb\u7642\u76ee\u6a19\u5f8c\uff0c\u5373\u86cb\u767d\u5c3f\u7de9\u89e3\uff08\u86cb\u767d\u5c3f<\/span><0.5 g\/d<\/span>\uff0c\u7406\u60f3\u60c5\u6cc1<\/span><0.3 g\/d<\/span>\uff09\u53ca\u814e\u529f\u80fd\u7a69\u5b9a\uff0c\u53ef\u4ee5\u63a1\u53d6\u5c0f\u5291\u91cf\u7dad\u6301\u6216\u91cd\u8986\u5b89\u5168\u6709\u6548\u7684\u514d\u75ab\u6cbb\u7642\u548c\u7e7c\u7e8c\u7dad\u6301\u652f\u6301\u6cbb\u7642\uff0c\u4ee5\u4fdd\u8b49<\/span>eGFR<\/span>\u6bcf\u5e74\u4e0b\u964d<\/span><1 ml\/min<\/span>\u3002\u6839\u64da\u6307\u5357\u9810\u5be9\u7248\u7684\u6307\u5f15\uff0c\u6211\u5011\u5236\u5b9a\u4e86\u91dd\u5c0d<\/span>IgA<\/span>\u814e\u75c5\u7684\u5e02\u5834\u53ca\u75be\u75c5\u7ba1\u7406\u7b56\u7565\uff0c\u5373\u300c\u5c0d\u56e0\u6cbb\u7642\u3001\u76e1\u65e9\u6cbb\u7642\u3001\u5168\u90e8\u6cbb\u7642\u3001\u9577\u671f\u6cbb\u7642\u300d\uff0c\u800c\u8010\u8ce6\u5eb7\u00ae<\/span>\u5168\u7403<\/span>III<\/span>\u671f\u7814\u7a76\u53ca\u4e9e\u7d44\u5206\u6790\u7684\u6578\u64da\u4e5f\u5168\u9762\u652f\u6301\u8a72\u6cbb\u7642\u7b56\u7565\u3002\u540c\u6642\uff0c\u6211\u5011\u5728\u4e0a\u534a\u5e74\u555f\u52d5\u4e86\u591a\u9805\u771f\u5be6\u4e16\u754c\u7814\u7a76\uff0c\u5305\u62ec\u91dd\u5c0d\u8010\u8ce6\u5eb7\u00ae<\/span>\u591a\u7a2e\u806f\u5408\u7528\u85e5\u65b9\u6848\u7684\u7814\u7a76\uff0c\u70ba\u91ab\u751f\u672a\u4f86\u81e8\u5e8a\u61c9\u7528\u63d0\u4f9b\u4f9d\u64da\uff0c\u4ee5\u652f\u6301\u8010\u8ce6\u5eb7\u00ae<\/span>\u9577\u671f\u7684\u92b7\u552e\u589e\u9577\u3002<\/span><\/p>\n

\u6b64\u5916\uff0c\u591a\u7bc7\u95dc\u65bc\u8010\u8ce6\u5eb7\u00ae<\/span>\u7684\u8ad6\u6587\u5df2\u5728\u6b0a\u5a01\u91ab\u5b78\u671f\u520a\u4e0a\u767c\u8868\uff0c\u5305\u62ec\u5317\u4eac\u5927\u5b78\u7b2c\u4e00\u91ab\u9662\u814e\u5167\u79d1\u5442\u7e7c\u6210\u6559\u6388\u7b49\u767c\u8868\u7684\u300a\u5e03\u5730\u5948\u5fb7\u8178\u6eb6\u81a0\u56ca\u5728<\/span>IgA<\/span>\u814e\u75c5\u4e2d\u7684\u514d\u75ab\u8abf\u7bc0\u4f5c\u7528\u548c\u7814\u7a76\u9032\u5c55\u300b\u548c\u300a\u9776\u5411\u91cb\u653e\u5e03\u5730\u5948\u5fb7\u8178\u6eb6\u81a0\u56ca\u6cbb\u7642<\/span>IgA<\/span>\u814e\u75c5\u6642<\/span>Gd-IgA1<\/span>\u8207\u591a\u805a<\/span>IgA<\/span>\u767c\u63ee\u7684\u9810\u6e2c\u50f9\u503c\u7814\u7a76\u300b\uff0c\u9577\u5f81\u91ab\u9662\u814e\u81df\u75c5\u79d1\u6bdb\u5fd7\u570b\u6559\u6388\u7b49\u767c\u8868\u7684\u300a\u9776\u5411\u91cb\u653e\u5e03\u5730\u5948\u5fb7\uff08<\/span>TRF-budesonide<\/span>\uff09\u6cbb\u7642<\/span>IgA<\/span>\u814e\u75c5\u7684\u6709\u6548\u6027\u8207\u5b89\u5168\u6027\uff1a\u4e00\u9805<\/span>Meta<\/span>\u5206\u6790\u300b\uff0c\u4e2d\u5c71\u5927\u5b78\u9644\u5c6c\u7b2c\u4e00\u91ab\u9662\u814e\u5167\u79d1\u9673\u5d34\u6559\u6388\u7b49\u767c\u8868\u7684\u300a<\/span>IgA<\/span>\u814e\u75c5\u8a3a\u7642\u65b0\u9032\u5c55\u300b \u4ee5\u53ca\u4e0a\u6d77\u4ea4\u901a\u5927\u5b78\u91ab\u5b78\u9662\u9644\u5c6c\u745e\u91d1\u91ab\u9662\u814e\u81df\u79d1\u4e3b\u4efb\u8b1d\u975c\u9060\u6559\u6388\u7b49\u767c\u8868\u7684\u300a\u5e03\u5730\u5948\u5fb7\u9776\u5411\u91cb\u653e\u5236\u5291\u6cbb\u7642\u4f34\u56b4\u91cd\u814e\u529f\u80fd\u640d\u5bb3\u7684<\/span>IgA<\/span>\u814e\u75c5\u300b\u3002<\/span><\/p>\n

\u4eca\u5e74\u4e0a\u534a\u5e74\uff0c\u6211\u5011\u9084\u9032\u4e00\u6b65\u63d0\u9ad8\u4e86\u4f9d\u5609\u00ae<\/span>\uff08\u4f9d\u62c9\u74b0\u7d20\uff09\u5728<\/span>300<\/span>\u5bb6\u5de6\u53f3\u6838\u5fc3\u91ab\u9662\u7684\u6ef2\u900f\uff0c\u7279\u5225\u662f\u5728\u5177\u6709\u8f03\u9ad8\u5e02\u5834\u6f5b\u529b\u7684\u91ab\u9662\u4e2d\uff0c\u92b7\u552e\u6536\u5165\u7a69\u6b65\u589e\u9577\u3002\u540c\u6642\u901a\u904e\u512a\u5316\u7684\u5408\u540c\u92b7\u552e\u7d44\u7e54\uff08<\/span>CSO<\/span>\uff09\u6a21\u5f0f\uff0c\u60e0\u53ca\u4e86\u66f4\u591a\u7684\u60a3\u8005\uff0c\u64f4\u5927\u4e86\u8a72\u9ad8\u7d1a\u5225\u6297\u83cc\u85e5\u7269\u7684\u53ef\u53ca\u6027\u3002\u4f9d\u62c9\u74b0\u7d20\u7684\u4e2d\u570b\u6298\u9ede\u5df2\u7372<\/span>CDE<\/span>\u6279\u51c6\u4e26\u66f4\u65b0\u9032\u8aaa\u660e\u66f8\u3002\u4eca\u5e74\u4f9d\u62c9\u74b0\u7d20\u5df2\u6709\u591a\u7bc7\u81e8\u5e8a\u61c9\u7528\u7684\u6578\u64da\u88ab\u767c\u8868\uff0c\u4e14\u88ab\u7d0d\u5165\u300a\u8840\u6db2\u816b\u7624\u60a3\u8005\u78b3\u9752\u9709\u70ef\u985e\u8010\u85e5\u8178\u687f\u83cc\u79d1\u7d30\u83cc\uff08<\/span>CRE<\/span>\uff09\u611f\u67d3\u7684\u8a3a\u6cbb\u8207\u9632\u63a7\u4e2d\u570b\u5c08\u5bb6\u5171\u8b58\uff08<\/span>2025 <\/span>\u5e74\u7248\uff09\u300b\u3002\u9019\u4e9b\u6587\u737b\u548c\u6307\u5357\u7684\u767c\u8868\u4e0d\u50c5\u9ad4\u73fe\u4e86\u91ab\u751f\u5c0d\u4f9d\u5609\u00ae<\/span>\u81e8\u5e8a\u50f9\u503c\u7684\u8a8d\u53ef\uff0c\u4e5f\u70ba\u4fc3\u9032\u4e86\u8a72\u7522\u54c1\u66f4\u5ee3\u6cdb\u5730\u5408\u7406\u61c9\u7528\u63d0\u4f9b\u4e86\u652f\u6301\u8b49\u64da\u3002<\/span><\/p>\n

\n

\u6a19\u984c<\/span><\/p>\n

\u520a\u7269<\/span><\/p>\n

\u767c\u8868\u65e5\u671f<\/span><\/p>\n

\u809d\u81df\u79fb\u690d\u8853\u5f8c\u591a\u91cd\u8010\u85e5\u83cc\u611f\u67d3\u8a3a\u7642\u7684\u591a\u4e2d\u5fc3\u5c08\u5bb6\u5171\u8b58<\/span><\/p>\n

\u4e2d\u570b\u666e\u5916\u57fa\u790e\u8207\u81e8\u5e8a\u96dc\u8a8c<\/span><\/p>\n

2025\/1<\/span><\/p>\n

\u8001\u5e74\u80ba\u708e\u81e8\u5e8a\u8a3a\u65b7\u8207\u6cbb\u7642\u5c08\u5bb6\u5171\u8b58\uff082024\u5e74\u7248\uff09<\/span><\/p>\n

\u4e2d\u83ef\u7d50\u6838\u548c\u547c\u5438\u96dc\u8a8c<\/span><\/p>\n

2025\/1<\/span><\/p>\n

\u809d\u79fb\u690d\u4f9b\u9ad4\u8010\u78b3\u9752\u9709\u70ef\u985e\u80ba\u708e\u514b\u96f7\u4f2f\u83cc\u611f\u67d3\u9632\u6cbb\u591a\u4e2d\u5fc3\u5c08\u5bb6\u5171\u8b58<\/span><\/p>\n

\u4e2d\u570b\u666e\u5916\u57fa\u790e\u8207\u81e8\u5e8a\u96dc\u8a8c<\/span><\/p>\n

2025\/2<\/span><\/p>\n

2023\u5e74\u5168\u570b\u8840\u6d41\u611f\u67d3\u7d30\u83cc\u8010\u85e5\u76e3\u6e2c\u5831\u544a\uff1a\u9769\u862d\u9670\u6027\u83cc<\/span><\/p>\n

\u4e2d\u83ef\u81e8\u5e8a\u611f\u67d3\u75c5\u96dc\u8a8c\uff08\u4e2d\u82f1\u6587\uff09<\/span><\/p>\n

2025\/2<\/span><\/p>\n

\u8166\u5ba4\u5167\u6ce8\u5c04\u4f9d\u62c9\u74b0\u7d20\u6cbb\u7642\u78b3\u9752\u9709\u70ef\u985e\u8010\u85e5\u9b91\u66fc\u4e0d\u52d5\u687f\u83cc\u8166\u819c\u708e\uff1a1\u4f8b\u75c5\u4f8b\u5831\u544a<\/span><\/p>\n

J Antimicrob Chemother<\/span><\/p>\n

2025\/3<\/span><\/p>\n

\u4f9d\u62c9\u74b0\u7d20\u7fa4\u9ad4\u85e5\u4ee3\u52d5\u529b\u5b78\u548c\u80ba\u90e8\u5efa\u6a21\uff0c\u4ee5\u53ca\u5fae\u751f\u7269\u5b78\u6298\u9ede\u548cPKPD\u754c\u503c\u78ba\u5b9a<\/span><\/p>\n

Antimicrob Agents Chemother<\/span><\/p>\n

2025\/3<\/span><\/p>\n

\u4f9d\u62c9\u74b0\u7d20\u85e5\u654f\u8a66\u9a57\u4e2d\u7d19\u7247\u64f4\u6563\u6cd5\u3001MIC\u8a66\u7d19\u689d\u6cd5\u548c\u8089\u6e6f\u5fae\u91cf\u7a00\u91cb\u6cd5\u7684\u6bd4\u8f03<\/span><\/p>\n

Clinical Microbiology Infections<\/span><\/p>\n

2025\/4<\/span><\/p>\n

\u4f2f\u514b\u970d\u723e\u5fb7\u83cc\u5fa9\u5408\u7fa4\u4e2d\u4e0d\u540c\u83cc\u682a\u7684\u7a2e\u985e\u5206\u5e03\u548c\u6297\u83cc\u85e5\u7269\u654f\u611f\u6027<\/span><\/p>\n

Microb Drug Resist.<\/span><\/p>\n

2025\/4<\/span><\/p>\n

\u4f9d\u62c9\u74b0\u7d20\u55ae\u7368\u6216\u8207\u5404\u7a2e\u6297\u751f\u7d20\u806f\u5408\u5c0d\u7522OXA-48\u8178\u687f\u83cc\u76ee\u7d30\u83cc\u7684\u9ad4\u5916\u5354\u540c\u6548\u61c9\u548c\u7a81\u8b8a\u9810\u9632\u6fc3\u5ea6<\/span><\/p>\n

J Antibiot (Tokyo)<\/span><\/p>\n

2025\/5<\/span><\/p>\n

\u4f9d\u62c9\u74b0\u7d20\u5c0d\u80ba\u708e\u514b\u96f7\u4f2f\u83cc\u5206\u96e2\u682a\u7684\u9ad4\u5916\u6297\u83cc\u6d3b\u6027\u7814\u7a76<\/span><\/p>\n

Microbiol Spectr.<\/span><\/p>\n

2025\/5<\/span><\/p>\n

\u4f0a\u9e97\u838e\u767d\u83cc\u81f4\u8001\u5e74\u5275\u50b7\u60a3\u8005\u6557\u8840\u75c7\u4f11\u514b\uff1a\u75c5\u4f8b\u5831\u544a\u53ca\u7cfb\u7d71\u6587\u737b\u7d9c\u8ff0<\/span><\/p>\n

Frontiers in Medicine<\/span><\/p>\n

2025\/5<\/span><\/p>\n

\u4f9d\u62c9\u74b0\u7d20\u8207\u66ff\u52a0\u74b0\u7d20\u806f\u5408\u65b9\u6848\u6cbb\u7642\u91cd\u75c7\u76e3\u8b77\u75c5\u623f\u60a3\u8005\u78b3\u9752\u9709\u70ef\u985e\u8010\u85e5\u9b91\u66fc\u4e0d\u52d5\u687f\u83cc\u80ba\u708e\u7684\u7642\u6548\u6bd4\u8f03<\/span><\/p>\n

Anti-infection Pharmacy<\/span><\/p>\n

2025\/5<\/span><\/p>\n

\u4f9d\u62c9\u74b0\u7d20\u4f5c\u70ba\u91cd\u75c7\u60a3\u8005\u96e3\u6cbb\u6027\u8010\u85e5\u9b91\u66fc\u4e0d\u52d5\u687f\u83cc\u611f\u67d3\u7684\u300c\u6700\u5f8c\u9632\u7dda\u300d\u85e5\u4ee3\u52d5\u529b\u5b78\u5206\u6790\u7684\u4e09\u4f8b\u75c5\u4f8b\u5831\u544a<\/span><\/p>\n

JAC Antimicrob Resist<\/span><\/p>\n

2025\/6<\/span><\/p>\n

\u8840\u6db2\u816b\u7624\u60a3\u8005\u78b3\u9752\u9709\u70ef\u985e\u8010\u85e5\u8178\u687f\u83cc\u79d1\u7d30\u83cc\uff08CRE\uff09\u611f\u67d3\u7684\u8a3a\u6cbb\u8207\u9632\u63a7\u4e2d\u570b\u5c08\u5bb6\u5171\u8b58\uff082025 \u5e74\u7248\uff09<\/span><\/p>\n

\u4e2d\u83ef\u8840\u6db2\u5b78\u96dc\u8a8c<\/span><\/p>\n

2025\/6<\/span><\/p>\n

\u4ee5\u4f9d\u62c9\u74b0\u7d20\u70ba\u57fa\u790e\u7684\u806f\u5408\u65b9\u6848\u6cbb\u7642ICU\u78b3\u9752\u9709\u70ef\u8010\u85e5\u9b91\u66fc\u4e0d\u52d5\u687f\u83cc\u80ba\u708e\u7642\u6548\u8207\u5b89\u5168\u6027\uff1a\u4e00\u9805\u56de\u9867\u6027\u7814\u7a76<\/span><\/p>\n

Infect Drug Resist.<\/span><\/p>\n

2025\/6<\/span><\/p>\n

\u4f9d\u62c9\u74b0\u7d20\u6cbb\u7642\u55dc\u9ea5\u82bd\u7a84\u98df\u55ae\u80de\u83cc\u611f\u67d3\u81e8\u5e8a\u7d50\u5c40<\/span><\/p>\n

Infect Dis Therapy<\/span><\/p>\n

2025\/6<\/span><\/p>\n

\u4f9d\u62c9\u74b0\u7d20\u9ad4\u5916\u85e5\u7269\u654f\u611f\u6027\u8a66\u9a57\u898f\u7bc4\uff082025\uff09<\/span><\/p>\n

\u4e2d\u83ef\u6aa2\u9a57\u91ab\u5b78\u96dc\u8a8c<\/span><\/p>\n

2025\/6<\/span><\/p>\n<\/div>\n

\u7dad\u9069\u5e73\u00ae<\/span>(<\/span>\u827e\u66f2\u83ab\u5fb7<\/span>)<\/span>\u76ee\u524d\u5df2\u5728\u5ee3\u6771\u7701<\/span>9<\/span>\u5bb6\u91ab\u7642\u6a5f\u69cb\u901a\u904e\u300c<\/span>\u6e2f\u6fb3\u85e5\u68b0\u901a\u300d<\/span>\u653f\u7b56\u5148\u884c\u4f7f\u7528\uff0c\u70ba\u5176\u9810\u8a08\u65bc<\/span>2026<\/span>\u5e74\u4e0a\u534a\u5e74\u5728\u4e2d\u570b\u7372\u5f97\u65b0\u85e5\u4e0a\u5e02\u6279\u51c6\u6253\u4e0b\u826f\u597d\u7684\u91ab\u751f\u548c\u60a3\u8005\u57fa\u790e\u3002\u6211\u5011\u5df2\u555f\u52d5\u5927\u7063\u5340\u771f\u5be6\u4e16\u754c\u7814\u7a76\uff0c\u4ee5\u7372\u53d6\u66f4\u591a\u81e8\u5e8a\u6578\u64da\u4e26\u70ba\u7d0d\u5165\u6cbb\u7642\u6307\u5357\u63d0\u4f9b\u4f9d\u64da\uff0c\u5f9e\u800c\u5728\u4e2d\u570b\u5927\u9678\u7372\u6279\u4e0a\u5e02\u5f8c\u70ba\u91ab\u751f\u63d0\u4f9b\u66f4\u591a\u7528\u85e5\u6307\u5c0e\u3002\u7e7c<\/span>2024<\/span>\u5e74<\/span>12<\/span>\u6708\uff0c\u827e\u66f2\u83ab\u5fb7\u88ab\u7d0d\u5165\u7f8e\u570b\u80c3\u8178\u75c5\u5354\u6703\uff08<\/span>AGA<\/span>\uff09\u81e8\u5e8a\u5be6\u8e10\u6307\u5357\uff0c\u4eca\u5e74<\/span>6<\/span>\u6708\u4efd\u53c8\u88ab\u7d0d\u5165\u7f8e\u570b\u80c3\u8178\u75c5\u5b78\u6703\uff08<\/span>ACG<\/span>\uff09\u81e8\u5e8a\u6307\u5357\uff0c\u5f37\u70c8\u63a8\u85a6\u5c07\u827e\u66f2\u83ab\u5fb7\u7528\u65bc\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\u60a3\u8005\u7684\u8a98\u5c0e\u7de9\u89e3\u6cbb\u7642\uff0c\u4e26\u5f37\u70c8\u63a8\u85a6\u5728\u7d93\u9798\u6c28\u9187<\/span>-1 –<\/span>\u78f7\u9178<\/span> (S1P) <\/span>\u53d7\u9ad4\u8abf\u7bc0\u5291\u8a98\u5c0e\u7de9\u89e3\u5f8c\u7e7c\u7e8c\u4f7f\u7528\u827e\u66f2\u83ab\u5fb7\u4ee5\u7dad\u6301\u7de9\u89e3\u3002\u6b64\u5916\uff0c\u70ba\u52a0\u5f37\u7dad\u9069\u5e73\u00ae<\/span>\u7684\u4f9b\u61c9\u4fdd\u969c\uff0c\u6211\u5011\u5728\u5609\u5584\u5de5\u5ee0\u6295\u8cc7<\/span>7000<\/span>\u842c\u5143\u4eba\u6c11\u5e63\u555f\u52d5\u4e86\u672c\u571f\u5316\u751f\u7522\u9805\u76ee\u3002\u9805\u76ee\u9054\u7522\u5f8c\u5e74\u7522\u80fd\u53ef\u9054<\/span>500<\/span>\u842c\u74f6\uff0c\u5c07\u6709\u529b\u4fdd\u969c\u9577\u671f\u7a69\u5b9a\u4f9b\u61c9\u3002<\/span><\/p>\n

\u5546\u696d\u5316\u5c55\u671b<\/span><\/p>\n

2025<\/span>\u5e74\u4e0b\u534a\u5e74\uff0c\u6211\u5011\u5c07\u7e7c\u7e8c\u52a0\u901f\u5546\u696d\u5316\u9032\u7a0b\uff0c\u64f4\u5927\u5275\u65b0\u7642\u6cd5\u7684\u53ef\u53ca\u6027\u3002\u76ee\u524d\u6b63\u5168\u529b\u63a8\u9032\u8010\u8ce6\u5eb7\u00ae<\/span>\u5728\u6838\u5fc3\u91ab\u9662\u7684\u5168\u9762\u91ab\u4fdd\u843d\u5730\uff0c\u540c\u6642\u901a\u904e\u91ab\u60a3\u6559\u80b2\u548c\u771f\u5be6\u4e16\u754c\u7814\u7a76\uff0c\u63d0\u5347\u91ab\u751f\u548c\u60a3\u8005\u5c0d\u300c\u5c0d\u56e0\u6cbb\u7642\u3001\u76e1\u65e9\u6cbb\u7642\u3001\u5168\u90e8\u6cbb\u7642\u3001\u9577\u671f\u6cbb\u7642\u300d\u6cbb\u7642\u7b56\u7565\u7684\u8a8d\u77e5\u3002\u6211\u5011\u9810\u8a08\u8010\u8ce6\u5eb7\u00ae<\/span>\u4e0b\u534a\u5e74\u5c07\u88ab\u6b63\u5f0f\u7d0d\u5165<\/span>2025<\/span>\u7248\u300a<\/span>KDIGO IgA<\/span>\u814e\u75c5\u548c<\/span>IgA<\/span>\u8840\u7ba1\u708e\u81e8\u5e8a\u7ba1\u7406\u5be6\u8e10\u6307\u5357\u300b\uff0c\u4e26\u7d0d\u5165\u4e2d\u570b\u9996\u500b<\/span>IgA<\/span>\u814e\u75c5\u81e8\u5e8a\u8a3a\u7642\u6307\u5357\uff0c\u9019\u4e9b\u6307\u5357\u7684\u7d0d\u5165\u5c07\u978f\u56fa\u8010\u8ce6\u5eb7\u00ae<\/span>\u4f5c\u70ba<\/span>IgA<\/span>\u814e\u75c5\u4e00\u7dda\u57fa\u77f3\u6cbb\u7642\u5730\u4f4d\u3002\u653e\u773c\u4e2d\u570b\u5927\u9678\u4ee5\u5916\u7684\u5730\u5340\uff0c\u8010\u8ce6\u5eb7\u00ae<\/span>\u5df2\u5728\u96f2\u9802\u65b0\u8000\u8986\u84cb\u7684\u6240\u6709\u6388\u6b0a\u5340\u57df\u5be6\u73fe\u5b8c\u5168\u6279\u51c6\uff0c\u978f\u56fa\u4e86\u5176\u5728\u4e9e\u6d32\u4f5c\u70ba<\/span>IgA<\/span>\u814e\u75c5\u4e00\u7dda\u6cbb\u7642\u57fa\u77f3\u7684\u5730\u4f4d\uff1b\u6211\u5011\u9810\u8a08\u8010\u8ce6\u5eb7\u00ae<\/span>\u7684\u6d77\u5916\u92b7\u552e\u8ca2\u737b\u5c07\u5f9e<\/span>2026<\/span>\u5e74\u958b\u59cb\u589e\u901f\uff0c\u5c46\u6642\u4e2d\u570b\u53f0\u7063\u5730\u5340\u548c\u97d3\u570b\u7684\u91ab\u4fdd\u5831\u92b7\u653f\u7b56\u6709\u671b\u6b63\u5f0f\u8986\u84cb\u8a72\u85e5\u7269\u3002<\/span><\/p>\n

2025<\/span>\u5e74<\/span>8<\/span>\u6708\uff0c\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u6b63\u5f0f\u6279\u51c6\u8010\u8ce6\u5eb7\u00ae<\/span>\u7684\u64f4\u7522\u88dc\u5145\u7533\u8acb\u3002\u4f5c\u70ba\u5168\u7403\u9996\u500b\u4e14\u76ee\u524d\u552f\u4e00\u5728\u4e2d\u570b\u3001\u7f8e\u570b\u548c\u6b50\u6d32\u7372\u5f97\u5b8c\u5168\u6279\u51c6\u7684<\/span>IgA<\/span>\u814e\u75c5\u5c0d\u56e0\u6cbb\u7642\u85e5\u7269\uff0c\u6b64\u6b21\u64f4\u7522\u7372\u6279\u5c07\u9032\u4e00\u6b65\u63d0\u5347\u8010\u8ce6\u5eb7\u00ae<\/span>\u7522\u80fd\uff0c\u589e\u52a0\u7522\u54c1\u4f9b\u61c9\uff0c\u66f4\u9ad8\u6548\u5730\u56de\u61c9\u4e2d\u570b\u53ca\u4e9e\u6d32\u5730\u5340\u5c0d\u8010\u8ce6\u5eb7\u00ae<\/span>\u7684\u6301\u7e8c\u589e\u9577\u7684\u81e8\u5e8a\u9700\u6c42\uff0c\u52a9\u529b\u66f4\u591a\u60a3\u8005\u76e1\u65e9\u958b\u555f\u898f\u7bc4\u6cbb\u7642\u3001\u63a8\u9072\u75be\u75c5\u9032\u5c55\u3001\u4fdd\u8b77\u814e\u529f\u80fd\u3002\u8010\u8ce6\u5eb7\u00ae<\/span>\u7684\u7522\u80fd\u64f4\u589e\u88dc\u5145\u7533\u8acb\u7372\u6279\uff0c\u70ba<\/span>2025<\/span>\u5e74\u4e0b\u534a\u5e74\u5927\u5e45\u7684\u92b7\u552e\u589e\u9577\u92ea\u5e73\u9053\u8def\u3002\u6211\u5011\u9810\u8a08\u8010\u8ce6\u5eb7\u00ae<\/span>\u5168\u5e74\u92b7\u552e\u984d\u5c07\u9054\u5230<\/span>12<\/span>\u81f3<\/span>14<\/span>\u5104\u5143\u4eba\u6c11\u5e63\u3002<\/span><\/p>\n

\u6211\u5011\u5c07\u6301\u7e8c\u63a8\u52d5\u4f9d\u5609\u00ae<\/span>\u5728\u6838\u5fc3\u91ab\u9662\u7684\u6df1\u5ea6\u6ef2\u900f\uff0c\u91cd\u9ede\u958b\u767c\u5e02\u5834\u6f5b\u529b\u7a81\u51fa\u7684\u91ab\u7642\u6a5f\u69cb\u4ee5\u53ca\u5c0d\u591a\u91cd\u8010\u85e5\u83cc\u611f\u67d3\u85e5\u7269\u9700\u6c42\u65fa\u76db\u7684\u79d1\u5ba4\u5982<\/span>ICU<\/span>\u7b49\u3002\u4f5c\u70ba\u5546\u696d\u5316\u6230\u7565\u7684\u91cd\u8981\u7d44\u6210\u90e8\u5206\uff0c\u6211\u5011\u5c07\u9032\u4e00\u6b65\u512a\u5316\u975e\u6838\u5fc3\u5e02\u5834\u7684<\/span>CSO<\/span>\uff08\u5408\u540c\u92b7\u552e\u7d44\u7e54\uff09\u5408\u4f5c\u6a21\u5f0f\uff0c\u4e26\u901a\u904e\u7cfb\u5217\u8209\u63aa\u63a8\u9032\u4f9d\u5609\u00ae<\/span>\u5411\u66f4\u524d\u7dda\u6cbb\u7642\u65b9\u6848\u7684\u5347\u7d1a\uff0c\u5c07\u5176\u6253\u9020\u6210\u70ba\u591a\u91cd\u8010\u85e5\u611f\u67d3\u7d93\u9a57\u6027\u6cbb\u7642\u4e2d\u4e0d\u53ef\u6216\u7f3a\u7684\u9078\u64c7\u3002\u8010\u8ce6\u5eb7\u00ae<\/span>\u548c\u4f9d\u5609\u00ae<\/span>\u5169\u6b3e\u7522\u54c1\u7684<\/span>2025<\/span>\u5e74\u5168\u5e74\u7e3d\u71df\u6536\u9810\u8a08\u5c07\u9054\u5230<\/span>16<\/span>\u81f3<\/span>18<\/span>\u5104\u5143\u4eba\u6c11\u5e63\u3002<\/span><\/p>\n

\u7dad\u9069\u5e73\u00ae<\/span>\u7684\u4e2d\u570b\u5927\u9678\u4e0a\u5e02\u7c4c\u5099\u5de5\u4f5c\u6b63\u5728\u7a4d\u6975\u63a8\u9032\u3002<\/span>2025<\/span>\u5e74\u4e0b\u534a\u5e74\uff0c\u6211\u5011\u5c07\u91cd\u9ede\u958b\u5c55\u4e0a\u5e02\u524d\u51c6\u5099\u5de5\u4f5c\u548c\u5927\u7063\u5340\u7684\u771f\u5be6\u4e16\u754c\u7814\u7a76\uff0c\u70ba\u5728<\/span>2026<\/span>\u5e74\u4e0a\u534a\u5e74\u7372\u5f97\u570b\u5bb6\u85e5\u76e3\u5c40\u6279\u51c6\u5f8c\u5feb\u901f\u5168\u9762\u9032\u5165\u4e2d\u570b\u5e02\u5834\u5960\u5b9a\u57fa\u790e\u3002<\/span><\/p>\n

\u81ea\u4e3b\u7814\u767c<\/span><\/p>\n

2025<\/span>\u5e74\u4e0a\u534a\u5e74\u662f\u516c\u53f8\u300c<\/span>\u96d9\u8f2a\u9a45\u52d5\u300d<\/span>\u6230\u7565\u8207<\/span>mRNA<\/span>\u5e73\u53f0\u767c\u5c55\u7684\u95dc\u9375\u57f7\u884c\u671f\u3002\u516d\u6708\uff0c\u516c\u53f8\u6210\u529f\u8209\u8fa6\u300c<\/span>2025<\/span>\u96f2\u9802\u65b0\u8000<\/span>mRNA<\/span>\u5275\u65b0\u6280\u8853\u5e73\u53f0\u7814\u767c\u65e5\u300d\uff0c\u96c6\u4e2d\u5c55\u793a\u4e86\u516c\u53f8\u81ea\u4e3b\u7814\u767c\u7684<\/span>AI<\/span>\u9a45\u52d5\u7684<\/span>mRNA<\/span>\u6280\u8853\u5e73\u53f0\u7684\u6700\u65b0\u9032\u5c55\uff0c\u5305\u542b\u4e86<\/span>mRNA<\/span>\u816b\u7624\u6cbb\u7642\u6027\u75ab\u82d7\u7ba1\u7dda\u548c\u81ea\u9ad4\u751f\u6210<\/span>CAR-T<\/span>\u5e73\u53f0\uff0c\u7528\u65bc\u958b\u767c\u816b\u7624\u53ca\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u9818\u57df\u3002<\/span><\/p>\n

\u4f5c\u70ba\u96f2\u9802\u65b0\u8000\u81ea\u4e3b\u7814\u767c\u7684\u9996\u6b3e\u500b\u6027\u5316<\/span>mRNA<\/span>\u6cbb\u7642\u6027\u816b\u7624\u75ab\u82d7\uff0c<\/span>EVM16 IIT<\/span>\u7814\u7a76\u4eca\u5e74<\/span>3<\/span>\u6708\u65bc\u5317\u4eac\u5927\u5b78\u816b\u7624\u91ab\u9662\u9806\u5229\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u7d66\u85e5\uff0c\u76ee\u524d\u5df2\u5b8c\u6210\u4f4e\u3001\u4e2d\u3001\u9ad8\u5291\u91cf<\/span>9<\/span>\u540d\u60a3\u8005\u7d66\u85e5\uff0c\u8a72\u81e8\u5e8a\u8a66\u9a57\u521d\u6b65\u6578\u64da\u986f\u793a\uff0c\u5373\u4f7f\u4f4e\u8d77\u59cb\u5291\u91cf\u4e5f\u80fd\u6fc0\u767c\u665a\u671f\u816b\u7624\u60a3\u8005\u7279\u7570\u6027<\/span>T<\/span>\u7d30\u80de\u53cd\u61c9\uff0c\u5177\u6709\u826f\u597d\u7684\u514d\u75ab\u539f\u6027\u3002<\/span>EVM16<\/span>\u6839\u64da\u6bcf\u4f4d\u60a3\u8005\u7279\u6709\u7684\u816b\u7624\u7d30\u80de\u7a81\u8b8a\uff0c\u4f7f\u7528\u81ea\u4e3b\u7814\u767c\u4e14\u5177\u5099\u81ea\u6211\u8fed\u4ee3\u80fd\u529b\u7684<\/span>EVER-NEO-1 \u300c<\/span>\u5999\u7b97\u300d\u816b\u7624\u65b0\u6297\u539f<\/span>AI<\/span>\u7b97\u6cd5\u7cfb\u7d71\uff0c\u8b58\u5225\u51fa\u5177\u6709\u8f03\u9ad8\u514d\u75ab\u539f\u6027\u6f5b\u529b\u7684\u816b\u7624\u65b0\u6297\u539f\uff0c\u4e26\u8a2d\u8a08\u51fa\u7de8\u78bc\u6578\u5341\u7a2e\u816b\u7624\u65b0\u6297\u539f\u7684<\/span>mRNA<\/span>\u75ab\u82d7\u3002<\/span>EVM16<\/span>\u901a\u904e\u8102\u8cea\u7d0d\u7c73\u9846\u7c92\uff08<\/span>LNP<\/span>\uff09\u905e\u9001\u7cfb\u7d71\u5728\u9ad4\u5167\u9032\u884c\u9ad8\u6548\u7684\u6297\u539f\u5448\u905e\uff0c\u555f\u52d5\u60a3\u8005\u81ea\u8eab\u7684\u65b0\u6297\u539f\u7279\u7570\u6027<\/span>T<\/span>\u7d30\u80de\u514d\u75ab\uff0c\u9032\u800c\u9054\u5230\u6bba\u50b7\u816b\u7624\u7d30\u80de\u548c\u6cbb\u7642\u764c\u75c7\u7684\u76ee\u7684\u3002<\/span><\/p>\n

\u81ea\u4e3b\u7814\u767c\u7684\u901a\u7528\u578b<\/span>TAA mRNA<\/span>\u816b\u7624\u75ab\u82d7<\/span>EVM14<\/span>\u5728\u4eca\u5e74\u4e0a\u534a\u5e74\u540c\u6642\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u7684\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\uff08<\/span>IND<\/span>\uff09\u6279\u51c6\uff0c\u4ee5\u53ca\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\u7684<\/span>IND<\/span>\u7533\u8acb\u53d7\u7406\uff0c\u6210\u70ba\u516c\u53f8\u9996\u500b\u5be6\u73fe\u4e2d\u7f8e\u96d9\u5831\u7684\u5019\u9078\u7522\u54c1\u3002\u9019\u662f\u4e00\u6b3e\u9776\u5411<\/span>5<\/span>\u500b\u816b\u7624\u76f8\u95dc\u6297\u539f\u7684\u901a\u7528\u578b\u7684\u73fe\u8ca8\u816b\u7624\u6cbb\u7642\u6027\u75ab\u82d7\uff0c\u64ec\u7528\u65bc\u9c57\u72c0\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u3001\u982d\u9838\u9c57\u764c\u7b49\u7624\u7a2e\u7684\u6cbb\u7642\u3002\u81e8\u5e8a\u524d\u8a66\u9a57\u7d50\u679c\u8868\u660e\uff0c<\/span>EVM14<\/span>\u5728\u5c0f\u9f20\u4e2d\u8a98\u5c0e\u4e86\u5291\u91cf\u4f9d\u8cf4\u6027\u7684\u6297\u539f\u7279\u7570\u6027\u514d\u75ab\u61c9\u7b54\uff0c\u4e26\u5728\u591a\u500b\u5c0f\u9f20\u540c\u6e90\u816b\u7624\u6a21\u578b\u4e2d\u986f\u8457\u5730\u6291\u5236\u4e86\u816b\u7624\u751f\u9577\u3002\u540c\u6642\uff0c<\/span>EVM14<\/span>\u80fd\u5920\u8a98\u5c0e\u514d\u75ab\u8a18\u61b6\uff0c\u5c55\u73fe\u51fa\u6709\u6548\u964d\u4f4e\u816b\u7624\u5fa9\u767c\u53ca\u8f49\u79fb\u7684\u80fd\u529b\u3002\u96f2\u9802\u65b0\u8000\u5609\u5584\u5de5\u5ee0\u5df2\u65bc<\/span>2025<\/span>\u5e74<\/span>6<\/span>\u6708<\/span>9<\/span>\u65e5\u9806\u5229\u653e\u884c\u9996\u6279<\/span>GMP<\/span>\u81e8\u5e8a\u8a66\u9a57\u6a23\u54c1\uff0c\u8a72\u6279\u6a23\u54c1\u5c07\u7528\u65bc\u652f\u6301\u96f2\u9802\u65b0\u8000\u5728\u4e2d\u7f8e\u5169\u5730\u958b\u5c55<\/span>EVM14<\/span>\u7684\u81e8\u5e8a\u8a66\u9a57\u3002\u5408\u4f5c\u7684\u81e8\u5e8a\u8a66\u9a57\u4e2d\u5fc3\u5305\u62ec\u7f8e\u570b<\/span>MD Anderson<\/span>\u764c\u75c7\u4e2d\u5fc3\u548c\u4e2d\u570b\u4e0a\u6d77\u5e02\u80f8\u79d1\u91ab\u9662\u7b49\u3002\u9019\u9a57\u8b49\u4e86\u516c\u53f8\u5177\u6709\u5168\u7522\u696d\u93c8\u80fd\u529b\u7684<\/span>mRNA <\/span>\u5e73\u53f0\uff0c\u6db5\u84cb\u6297\u539f\u8a2d\u8a08\u3001\u57fa\u65bc<\/span>LNP<\/span>\u7684\u905e\u9001\u7cfb\u7d71\u3001<\/span>CMC<\/span>\u5de5\u85dd\u958b\u767c\u548c\u7b26\u5408<\/span>GMP<\/span>\u898f\u7bc4\u7684\u751f\u7522\u88fd\u9020\u7b49\u95dc\u9375\u74b0\u7bc0\uff0c\u70ba\u672a\u4f86\u7ba1\u7dda\u63a8\u9032\u81e8\u5e8a\u548c\u5546\u696d\u5316\u5960\u5b9a\u4e86\u5805\u5be6\u57fa\u790e\u3002\u6211\u5011\u9810\u8a08\u8a72\u9805\u76ee\u5c07\u65bc<\/span>2026<\/span>\u5e74\u7372\u5f97\u81e8\u5e8a\u6578\u64da\u8b80\u51fa\u3002<\/span><\/p>\n

2025<\/span>\u5e74\u4e0a\u534a\u5e74\uff0c\u6211\u5011\u7684<\/span>mRNA<\/span>\u81ea\u9ad4\u751f\u6210<\/span>CAR-T<\/span>\u5e73\u53f0\u4e5f\u53d6\u5f97\u4e86\u91cd\u8981\u9032\u5c55\u3002\u516c\u53f8\u57fa\u65bc\u81ea\u4e3b\u7814\u767c\u7684\u9776\u5411<\/span>LNP<\/span>\uff08<\/span>tLNP<\/span>\uff09\u7cfb\u7d71\u958b\u767c\u7684\u81ea\u9ad4\u751f\u6210<\/span>CAR-T<\/span>\u9805\u76ee\u5df2\u53d6\u5f97\u591a\u9805\u81e8\u5e8a\u524d\u9a57\u8b49\u6210\u679c\u3002\u516c\u53f8\u5df2\u5efa\u7acb\u4e00\u7a2e\u7a69\u5b9a\u7684\u5076\u806f\u65b9\u6cd5\uff0c\u78ba\u4fdd\u5076\u806f\u6548\u7387\u7684\u4e00\u81f4\u6027\u548c\u9ad8\u6548\u6027\uff1b\u4e26\u7be9\u9078\u51fa\u53ef\u6709\u6548\u5f15\u5c0e<\/span>CAR<\/span>\u5728<\/span>T<\/span>\u7d30\u80de\u4e2d\u7279\u7570\u4e14\u9ad8\u6548\u8868\u9054\u7684\u9776\u5411\u5206\u5b50\u3002\u5728\u4eba\u6e90\u5316\u5c0f\u9f20\u816b\u7624\u6a21\u578b\u4e2d\uff0c\u8a72\u7642\u6cd5\u5df2\u5be6\u73fe\u6709\u6548\u7684\u816b\u7624\u7d30\u80de\u6e05\u9664\uff1b\u5728\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\uff08\u7334\uff09\u6a21\u578b\u4e2d\uff0c\u4e5f\u5df2\u9a57\u8b49<\/span>T<\/span>\u7d30\u80de\u7684\u9ad8\u6548\u8f49\u67d3\u3001<\/span>CAR<\/span>\u7684\u8868\u9054\u4ee5\u53ca<\/span>B<\/span>\u7d30\u80de\u7684\u6e05\u9664\u6548\u679c\uff0c\u6f5b\u5728\u958b\u767c\u7528\u65bc\u816b\u7624\u53ca\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u3002\u9019\u4e00\u7642\u6cd5\u96d6\u7136\u4ecd\u8655\u65bc\u65e9\u671f\u7814\u767c\u968e\u6bb5\uff0c\u4f46\u6709\u671b\u6210\u70ba\u50b3\u7d71<\/span>CAR-T<\/span>\u7642\u6cd5\u7684\u9769\u547d\u6027\u66ff\u4ee3\u65b9\u6848\uff0c\u5728\u60a3\u8005\u53ef\u53ca\u6027\u3001\u73fe\u8ca8\u578b\u548c\u898f\u6a21\u5316\u751f\u7522\u7b49\u591a\u65b9\u9762\u5c55\u73fe\u51fa\u986f\u8457\u512a\u52e2\u3002<\/span><\/p>\n

\u5c55\u671b<\/span>2025<\/span>\u5e74\u4e0b\u534a\u5e74\uff0c\u6211\u5011\u7684<\/span>mRNA<\/span>\u7814\u767c\u7ba1\u7dda\uff0c\u5305\u542b<\/span>mRNA<\/span>\u816b\u7624\u6cbb\u7642\u6027\u75ab\u82d7\u548c\u81ea\u9ad4\u751f\u6210<\/span>CAR-T<\/span>\u5e73\u53f0\uff0c\u9810\u8a08\u5c07\u5be6\u73fe\u591a\u9805\u91cd\u8981\u91cc\u7a0b\u7891\u3002\u500b\u6027\u5316\u816b\u7624\u75ab\u82d7<\/span>EVM16<\/span>\u5c07\u6309\u8a08\u5283\u5b8c\u6210<\/span>Ia<\/span>\u968e\u6bb5\u60a3\u8005\u5165\u7d44\uff0c\u4e26\u7372\u5f97\u5b89\u5168\u6027\u548c\u514d\u75ab\u539f\u6027\u7684\u521d\u6b65\u4eba\u9ad4\u6578\u64da\u3002\u91dd\u5c0d<\/span>EVM14<\/span>\u9805\u76ee\uff0c\u6211\u5011\u9810\u8a08\u5c07\u5728\u7f8e\u570b\u555f\u52d5\u9996\u4f8b\u60a3\u8005\u7d66\u85e5\uff0c\u4e26\u6709\u671b\u7372\u5f97\u4e2d\u570b\u570b\u5bb6\u85e5\u76e3\u5c40\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\u7684<\/span>IND<\/span>\u6279\u51c6\u3002\u514d\u75ab\u8abf\u7bc0\u816b\u7624\u75ab\u82d7<\/span>EVM15<\/span>\u7684\u81e8\u5e8a\u524d\u7814\u7a76\u6b63\u5728\u9032\u884c\u4e2d\uff0c\u9810\u8a08<\/span>2025<\/span>\u5e74\u5167\u53d6\u5f97\u81e8\u5e8a\u524d\u6982\u5ff5\u9a57\u8b49\u3002\u8207\u6b64\u540c\u6642\uff0c\u81ea\u9ad4\u751f\u6210<\/span>CAR-T<\/span>\u5e73\u53f0\u9810\u8a08\u5728\u4e0b\u534a\u5e74\u78ba\u5b9a\u81e8\u5e8a\u5019\u9078\u5206\u5b50\uff0c\u5f9e\u800c\u6709\u671b\u5728<\/span>2026<\/span>\u5e74\u7372\u53d6\u9996\u6279\u4eba\u9ad4\u81e8\u5e8a\u6578\u64da\u3002<\/span><\/p>\n

\u696d\u52d9\u62d3\u5c55<\/span><\/p>\n

2025<\/span>\u5e74\uff0c\u6211\u5011\u7684\u696d\u52d9\u767c\u5c55\u6230\u7565\u5c07\u59cb\u7d42\u805a\u7126\u65bc\u9ad8\u81e8\u5e8a\u50f9\u503c\u3001\u5177\u6709\u5dee\u7570\u5316\u7684\u5168\u7403\u9996\u5275\u6216\u540c\u985e\u6700\u4f73\u8cc7\u7522\uff0c\u91cd\u9ede\u5e03\u5c40\u814e\u81df\u75be\u75c5\u3001\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u548c\u6297\u611f\u67d3\u85e5\u7269\u4e09\u5927\u9818\u57df\u3002<\/span><\/p>\n

\u5728\u6388\u6b0a\u5f15\u9032\u65b9\u9762\uff0c\u6211\u5011\u5c07\u7e7c\u7e8c\u5c0b\u6c42\u8655\u65bc\u5546\u696d\u5316\u6216\u81e8\u8fd1\u5546\u696d\u5316\u968e\u6bb5\u7684\u8cc7\u7522\uff0c\u501f\u52a9\u5728\u4e2d\u570b\u5df2\u5efa\u7acb\u7684\u9ad8\u6548\u5546\u696d\u5316\u5e73\u53f0\u5be6\u73fe\u904b\u71df\u5354\u540c\u6548\u61c9\u4e26\u5f62\u6210\u898f\u6a21\u512a\u52e2\u3002\u540c\u6642\uff0c\u6211\u5011\u4ecd\u5c07\u7a4d\u6975\u767c\u6398\u5177\u6709\u5168\u7403\u6b0a\u76ca\u7684\u65e9\u671f\u968e\u6bb5\u8cc7\u7522\uff0c\u901a\u904e\u5feb\u901f\u7372\u5f97\u81e8\u5e8a\u6982\u5ff5\u9a57\u8b49\uff08<\/span>POC<\/span>\uff09\u6578\u64da\u70ba\u80a1\u6771\u5275\u9020\u986f\u8457\u50f9\u503c\u3002<\/span><\/p>\n

\u5728\u5c0d\u5916\u6388\u6b0a\u65b9\u9762\uff0c\u6211\u5011\u6b63\u7a4d\u6975\u70ba\u5177\u6709\u5168\u7403\u6b0a\u76ca\u7684\u65e9\u671f\u8cc7\u7522\u5c0b\u6c42\u570b\u969b\u5408\u4f5c\u6a5f\u6703\u3002\u65b0\u4e00\u4ee3\u5171\u50f9\u53ef\u9006<\/span>BTK<\/span>\u6291\u5236\u5291<\/span>EVER001<\/span>\uff08\u5e0c\u5e03\u66ff\u5c3c\uff09\u5373\u5c07\u5b8c\u6210<\/span>Ib\/IIa<\/span>\u671f\u81e8\u5e8a\u8a66\u9a57\u539f\u767c\u6027\u819c\u6027\u814e\u75c5\u60a3\u8005\u7684<\/span>1<\/span>\u5e74\u96a8\u8a2a\u6578\u64da\uff0c\u5176\u6578\u64da\u9810\u8a08\u5c07\u65bc<\/span>9<\/span>\u6708\u516c\u5e03\u3002\u57fa\u65bc\u512a\u7570\u7684\u5b89\u5168\u6027\u548c\u81e8\u5e8a\u7372\u76ca\uff0c<\/span>EVER001<\/span>\u6709\u671b\u9806\u5229\u63a8\u9032\u81f3\u4e0b\u4e00\u81e8\u5e8a\u968e\u6bb5\uff0c\u4e26\u958b\u5c55\u91dd\u5c0d\u591a\u7a2e\u81ea\u8eab\u514d\u75ab\u6027\u814e\u81df\u75be\u75c5\u7684\u7c43\u5b50\u8a66\u9a57\uff08<\/span>basket trial<\/span>\uff09\uff0c\u5f9e\u800c\u52a0\u901f\u7814\u767c\u9032\u7a0b\u4e26\u64f4\u5927\u51fa\u6d77\u6f5b\u529b\u3002\u57fa\u65bc<\/span>mRNA<\/span>\u5e73\u53f0\u7684\u6cbb\u7642\u6027\u816b\u7624\u75ab\u82d7\u9805\u76ee<\/span>EVM16<\/span>\uff08\u500b\u6027\u5316\u816b\u7624\u75ab\u82d7\uff09\u548c<\/span>EVM14<\/span>\uff08<\/span>TAA<\/span>\u75ab\u82d7\uff09\u5c07\u5206\u5225\u65bc\u4eca\u5e74\u4e0b\u534a\u5e74\u548c\u660e\u5e74\u4e0a\u534a\u5e74\u7372\u5f97\u95dc\u9375\u7684\u521d\u6b65\u4eba\u9ad4\u6578\u64da\uff0c\u70ba\u6f5b\u5728\u7684\u5168\u7403\u5408\u4f5c\u6253\u4e0b\u5805\u5be6\u57fa\u790e\uff1b\u540c\u6642\uff0c\u6211\u5011\u7684<\/span>mRNA<\/span>\u81ea\u9ad4\u751f\u6210<\/span>CAR-T<\/span>\u9805\u76ee\uff0c\u5c07\u65bc\u4eca\u5e74\u4e0b\u534a\u5e74\u5728\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u4e2d\u7372\u5f97\u81e8\u5e8a\u524d\u6982\u5ff5\u9a57\u8b49\uff0c\u6709\u671b\u78ba\u5b9a\u9996\u500b\u81e8\u5e8a\u524d\u5019\u9078\u85e5\u7269\uff0c\u9019\u5c07\u986f\u8457\u63d0\u5347\u8a72\u9805\u76ee\u7684\u5c0d\u5916\u6388\u6b0a\u50f9\u503c\u3002\u6211\u5011\u6df1\u4fe1\uff0c\u6230\u7565\u6027\u570b\u969b\u5408\u4f5c\u4f19\u4f34\u95dc\u4fc2\u5c07\u662f\u6700\u5927\u5316\u5275\u65b0\u7ba1\u7dda\u9577\u671f\u50f9\u503c\u7684\u95dc\u9375\u3002<\/span><\/p>\n

\u4eca\u5e74<\/span>8<\/span>\u6708\uff0c\u6211\u5011\u4e5f\u975e\u5e38\u9ad8\u8208\u6210\u529f\u5730\u6230\u7565\u589e\u6301<\/span>I-Mab<\/span>\u516c\u53f8\u80a1\u6b0a\uff0c\u5411<\/span>I-Mab<\/span>\u516c\u53f8\u6295\u8cc7<\/span>3,090<\/span>\u842c\u7f8e\u5143\u3002\u52a0\u4e0a\u6b64\u524d\u5df2\u6301\u6709\u7684<\/span>I-Mab<\/span>\u80a1\u4efd\u5728\u5167\uff0c\u516c\u53f8\u5408\u8a08\u6301\u6709<\/span>I-Mab<\/span>\u7d04<\/span>16.1%<\/span>\u7684\u80a1\u4efd\uff0c\u6210\u70ba<\/span>I-Mab<\/span>\u7684\u7b2c\u4e00\u5927\u80a1\u6771\u3002<\/span>I-Mab<\/span>\u662f\u4e00\u5bb6\u5c08\u6ce8\u65bc\u816b\u7624\u7cbe\u6e96\u514d\u75ab\u6cbb\u7642\u7684\u5168\u7403\u6027\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u65bc\u7f8e\u570b\u7d0d\u65af\u9054\u514b\u5168\u7403\u5e02\u5834\u639b\u724c\u4e0a\u5e02\u3002\u6b64\u6b21\u589e\u52a0\u5c0d<\/span>I-Mab<\/span>\u7684\u6230\u7565\u6027\u80a1\u6b0a\u6295\u8cc7\u9032\u4e00\u6b65\u63a8\u52d5\u4e86\u6211\u5011\u5728\u5168\u7403\u7bc4\u570d\u5e03\u5c40\u65b0\u4e00\u4ee3\u816b\u7624\u514d\u75ab\u6cbb\u7642\u7ba1\u7dda\uff0c\u6a19\u8a8c\u8457\u96f2\u9802\u65b0\u8000\u5728\u65b0\u4e00\u4ee3\u816b\u7624\u514d\u75ab\u7642\u6cd5\u9818\u57df\u7684\u6230\u7565\u5e03\u5c40\u9081\u51fa\u95dc\u9375\u4e00\u6b65\u3002\u96d9\u65b9\u6709\u671b\u5145\u5206\u767c\u63ee\u5404\u81ea\u5728\u4e2d\u7f8e\u5169\u5730\u7684\u5c08\u696d\u80fd\u529b\uff0c\u5354\u540c\u958b\u5c55\u81e8\u5e8a\u958b\u767c\u548c\u5546\u52d9\u62d3\u5c55\u3002<\/span><\/p>\n

\u516c\u53f8\u767c\u5c55<\/span><\/p>\n

– 2025<\/span>\u5e74<\/span>4<\/span>\u6708\uff0c\u96f2\u9802\u65b0\u8000\u80a1\u4efd\u7c21\u7a31\u4e2d\u7684\u300c<\/span>B\u300d<\/span>\u6a19\u8a18\u7372\u5f97\u6279\u51c6\u79fb\u9664\uff0c\u76f8\u95dc\u8b8a\u66f4\u81ea<\/span>2025<\/span>\u5e74<\/span>5<\/span>\u6708<\/span>2<\/span>\u65e5\u8d77\u6b63\u5f0f\u751f\u6548\u3002\u80a1\u4efd\u7c21\u7a31\u300c<\/span>B\u300d<\/span>\u6a19\u8a18\u7684\u79fb\u9664\u7531\u9999\u6e2f\u806f\u4ea4\u6240\u6279\u51c6\u3002\u79fb\u9664\u300c<\/span>B\u300d<\/span>\u6a19\u8a18\u9ad4\u73fe\u96f2\u9802\u65b0\u8000\u5728\u7814\u767c\u7ba1\u7dda\u3001\u5546\u696d\u5316\u80fd\u529b\u53ca\u6574\u9ad4\u696d\u52d9\u57fa\u672c\u9762\u7684\u7d9c\u5408\u8003\u616e\u8207\u80fd\u529b\u3002<\/span><\/p>\n

– 2025<\/span>\u5e74<\/span>7<\/span>\u6708\uff0c\u516c\u53f8\u5ba3\u5e03\u4ee5\u5148\u820a\u5f8c\u65b0\u914d\u552e<\/span>22,561,000<\/span>\u80a1\uff0c\u52df\u8cc7\u7d04<\/span>15.5<\/span>\u5104\u6e2f\u5143\u3002\u6b64\u6b21\u914d\u552e\u53d7\u5230\u591a\u5bb6\u570b\u969b\u9577\u7dda\u6301\u6709\u57fa\u91d1\u9752\u775e\uff0c\u7372\u5f97\u6578\u500d\u8d85\u984d\u8a8d\u8cfc\uff0c\u53cd\u6620\u4e86\u8cc7\u672c\u5e02\u5834\u5c0d\u516c\u53f8\u5546\u696d\u5316\u80fd\u529b\u8207\u5275\u65b0\u7814\u767c\u5be6\u529b\u7684\u9ad8\u5ea6\u8a8d\u53ef\uff0c\u4e5f\u9ad4\u73fe\u51fa\u6295\u8cc7\u8005\u5c0d\u516c\u53f8\u9577\u671f\u767c\u5c55\u6230\u7565\u7684\u5145\u5206\u4fe1\u5fc3\u3002\u6211\u5011\u5c07\u5145\u5206\u5229\u7528\u6b64\u6b21\u878d\u8cc7\u6240\u5f97\uff0c\u52a0\u5feb\u5275\u65b0\u85e5\u7269\u548c<\/span>AI+mRNA<\/span>\u5e73\u53f0\u7684\u958b\u767c\uff0c\u540c\u6642\u63a8\u9032\u73fe\u6709\u7522\u54c1\u7684\u5546\u696d\u5316\u9032\u7a0b\u3002<\/span><\/p>\n

– 2025<\/span>\u5e74<\/span>8<\/span>\u6708\uff0c\u516c\u53f8\u5ba3\u5e03\u6230\u7565\u589e\u6301<\/span>I-Mab<\/span>\u516c\u53f8\u80a1\u6b0a\u3002\u96f2\u9802\u65b0\u8000\u5c07\u5411<\/span>I-Mab<\/span>\u516c\u53f8\u6295\u8cc7<\/span>3,090<\/span>\u842c\u7f8e\u5143\u3002\u4ea4\u6613\u5b8c\u6210\u5f8c\uff0c\u52a0\u4e0a\u6b64\u524d\u96f2\u9802\u65b0\u8000\u5df2\u6301\u6709\u7684<\/span>I-Mab<\/span>\u80a1\u4efd\u5728\u5167\uff0c\u516c\u53f8\u5c07\u5408\u8a08\u6301\u6709<\/span>I-Mab<\/span>\u7d04<\/span>16.1%<\/span>\u7684\u80a1\u4efd\uff0c\u6210\u70ba<\/span>I-Mab<\/span>\u7684\u7b2c\u4e00\u5927\u80a1\u6771\u3002<\/span>I-Mab<\/span>\u662f\u4e00\u5bb6\u5c08\u6ce8\u65bc\u816b\u7624\u7cbe\u6e96\u514d\u75ab\u6cbb\u7642\u7684\u5168\u7403\u6027\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u65bc\u7f8e\u570b\u7d0d\u65af\u9054\u514b\u5168\u7403\u5e02\u5834\u639b\u724c\u4e0a\u5e02\u3002<\/span><\/p>\n

\u8ca1\u52d9\u4eae\u9ede<\/span><\/p>\n

\u570b\u969b\u8ca1\u52d9\u5831\u544a\u6e96\u5247\u6578\u5b57<\/span><\/p>\n

\u622a\u81f3<\/span>2025<\/span>\u5e74<\/span>6<\/span>\u6708<\/span>30<\/span>\u65e5\u6b62\u516d\u500b\u6708\u7684\u6536\u76ca\u5927\u5e45\u589e\u52a0\u4eba\u6c11\u5e63<\/span>144.6<\/span>\u767e\u842c\u6e2f\u5143\u6216<\/span>48.0%<\/span>\u81f3\u4eba\u6c11\u5e63<\/span>446.1<\/span>\u767e\u842c\u5143\uff0c\u800c\u622a\u81f3<\/span>2024<\/span>\u5e74<\/span>6<\/span>\u6708<\/span>30<\/span>\u65e5\u6b62\u516d\u500b\u6708\u5247\u70ba\u4eba\u6c11\u5e63<\/span>301.5<\/span>\u767e\u842c\u5143\u3002\u6536\u76ca\u589e\u52a0\u4e3b\u8981\u7531\u65bc\u8010\u8ce6\u5eb7\u00ae<\/span>\u53ca\u4f9d\u5609\u00ae<\/span>\u5728\u5df2\u5546\u696d\u5316\u5e02\u5834\u4e0a\u6301\u7e8c\u589e\u9577\u6240\u81f4\u3002<\/span><\/p>\n

\u4e2d\u570b\u5e02\u5834\u65b9\u9762\uff0c\u8010\u8ce6\u5eb7\u00ae<\/span>\u7372\u7d0d\u5165\u570b\u5bb6\u91ab\u4fdd\u85e5\u54c1\u76ee\u9304\uff0c\u4e26\u6210\u70ba\u4e3b\u8981\u589e\u9577\u52d5\u529b\uff0c\u4f7f\u8010\u8ce6\u5eb7\u00ae<\/span>\u622a\u81f3<\/span>2025<\/span>\u5e74<\/span>6<\/span>\u6708<\/span>30<\/span>\u65e5\u6b62\u516d\u500b\u6708\u7684\u6536\u76ca\u5927\u5e45\u589e\u52a0\u3002\u4f9d\u5609\u00ae<\/span>\u7684\u5e02\u5834\u6ef2\u900f\u7387\u6301\u7e8c\u6df1\u5316\uff0c\u70ba\u6536\u76ca\u6301\u7e8c\u589e\u9577\u4f5c\u51fa\u8ca2\u737b\u3002\u540c\u6642\uff0c\u8010\u8ce6\u5eb7\u00ae<\/span>\u5728\u53f0\u7063\u6210\u529f\u4e0a\u5e02\uff0c\u9054\u6210\u91cc\u7a0b\u7891\u3002 <\/span><\/p>\n

\u4e2d\u570b\u5883\u5916\u5e02\u5834\u65b9\u9762\uff0c\u7dad\u9069\u5e73\u00ae<\/span>\u65bc<\/span>2025<\/span>\u5e74\u4e0a\u534a\u5e74\u6210\u529f\u5f15\u5165\u65b0\u52a0\u5761\u5e02\u5834\u3002\u8a72\u7b49\u6210\u5c31\u5f70\u986f\u672c\u96c6\u5718\u5728\u62d3\u5c55\u570b\u969b\u5e02\u5834\u53ca\u63d0\u5347\u85e5\u7269\u53ef\u53ca\u6027\u65b9\u9762\u7684\u9032\u5c55\u3002<\/span><\/p>\n

\u6bdb\u5229\u7387\u7531\u622a\u81f3<\/span>2024<\/span>\u5e74<\/span>6<\/span>\u6708<\/span>30<\/span>\u65e5\u6b62\u516d\u500b\u6708\u7684<\/span>76.6%<\/span>\u6e1b\u5c11\u81f3\u622a\u81f3<\/span>2025<\/span>\u5e74<\/span>6<\/span>\u6708<\/span>30<\/span>\u65e5\u6b62\u516d\u500b\u6708\u7684<\/span>67.1%<\/span>\u3002\u5254\u9664\u7121\u5f62\u8cc7\u7522\u6524\u92b7\u5f8c\uff0c\u6bdb\u5229\u7387\u7531\u622a\u81f3<\/span>2024<\/span>\u5e74<\/span>6<\/span>\u6708<\/span>30<\/span>\u65e5\u6b62\u516d\u500b\u6708\u7684<\/span>83.0%<\/span>\u6e1b\u5c11\u81f3\u622a\u81f3<\/span>2025<\/span>\u5e74<\/span>6<\/span>\u6708<\/span>30<\/span>\u65e5\u6b62\u516d\u500b\u6708\u7684<\/span>76.4%<\/span>\u3002\u6e1b\u5c11\u4e3b\u8981\u7531\u65bc\u8010\u8ce6\u5eb7\u00ae<\/span>\u5728\u4e2d\u570b\u5927\u9678\u7684\u570b\u5bb6\u91ab\u4fdd\u85e5\u54c1\u76ee\u9304\u50f9\u683c\u4e0b\u8abf\u53ca\u512a\u5316\u7522\u54c1\u6210\u672c\u6240\u81f4\u3002<\/span><\/p>\n

\u7814\u767c\uff08\u300c\u7814\u767c\u300d\uff09\u958b\u652f\u7531\u622a\u81f3<\/span>2024<\/span>\u5e74<\/span>6<\/span>\u6708<\/span>30<\/span>\u65e5\u6b62\u516d\u500b\u6708\u7684\u4eba\u6c11\u5e63<\/span>253.2<\/span>\u767e\u842c\u5143\u6e1b\u5c11\u81f3\u622a\u81f3<\/span>2025<\/span>\u5e74<\/span>6<\/span>\u6708<\/span>30<\/span>\u65e5\u6b62\u516d\u500b\u6708\u7684\u4eba\u6c11\u5e63<\/span>195.2<\/span>\u767e\u842c\u5143\uff0c\u53cd\u6620\u7b56\u7565\u8cc7\u6e90\u512a\u5316\uff0c\u5c08\u6ce8\u65bc\u6838\u5fc3\u7ba1\u7dda\u7a81\u7834\u3002<\/span><\/p>\n

\u5728\u4e0a\u534a\u5e74\u5be6\u73fe\u591a\u500b\u7814\u767c\u91cc\u7a0b\u7891\u7684\u540c\u6642\uff0c\u672c\u516c\u53f8\u6b63\u7a4d\u6975\u512a\u5316\u7814\u767c\u7b56\u7565\uff0c\u52a0\u5feb\u958b\u767c\u81ea\u9ad4\u751f\u6210<\/span>CAR-T<\/span>\u53ca<\/span>mRNA<\/span>\u5e73\u53f0\uff0c\u70ba\u4e0b\u4e00\u968e\u6bb5\u7684\u7814\u7a76\u53ca\u81e8\u5e8a\u505a\u597d\u51c6\u5099\uff0c\u4e26\u7e7c\u7e8c\u958b\u767c<\/span>EVER001 (Civorebrutinib)<\/span>\u7684\u50f9\u503c\u3002<\/span><\/p>\n

\u4e00\u822c\u53ca\u884c\u653f\u958b\u652f\u7531\u622a\u81f3<\/span>2024<\/span>\u5e74<\/span>6<\/span>\u6708<\/span>30<\/span>\u65e5\u6b62\u516d\u500b\u6708\u7684\u4eba\u6c11\u5e63<\/span>87.0<\/span>\u767e\u842c\u5143\u589e\u52a0\u4eba\u6c11\u5e63<\/span>23.8<\/span>\u767e\u842c\u5143\u81f3\u622a\u81f3<\/span>2025<\/span>\u5e74<\/span>6<\/span>\u6708<\/span>30<\/span>\u65e5\u6b62\u516d\u500b\u6708\u7684\u4eba\u6c11\u5e63<\/span>110.8<\/span>\u767e\u842c\u5143\u3002\u8a72\u589e\u52a0\u4e3b\u8981\u7531\u65bc\u50f1\u54e1\u4eba\u6578\u589e\u52a0\u6240\u81f4\uff0c\u53cd\u6620\u70ba\u652f\u6301\u7ba1\u7dda\u767c\u5c55\u53ca\u5e02\u5834\u64f4\u5f35\u800c\u9032\u884c\u7684\u91dd\u5c0d\u6027\u4eba\u624d\u6295\u8cc7\uff0c\u4ee5\u914d\u5408\u6211\u5011\u7684\u7b56\u7565\u6027\u589e\u9577\u63aa\u65bd\u3002<\/span><\/p>\n

\u5206\u92b7\u53ca\u92b7\u552e\u958b\u652f\u7531\u622a\u81f3<\/span>2024<\/span>\u5e74<\/span>6<\/span>\u6708<\/span>30<\/span>\u65e5\u6b62\u516d\u500b\u6708\u7684\u4eba\u6c11\u5e63<\/span>200.4<\/span>\u767e\u842c\u5143\u589e\u52a0\u4eba\u6c11\u5e63<\/span>114.4<\/span>\u767e\u842c\u5143\u81f3\u622a\u81f3<\/span>2025<\/span>\u5e74<\/span>6<\/span>\u6708<\/span>30<\/span>\u65e5\u6b62\u516d\u500b\u6708\u7684\u4eba\u6c11\u5e63<\/span>314.7<\/span>\u767e\u842c\u5143\u3002\u8a72\u589e\u52a0\u4e3b\u8981\u7531\u4ee5\u4e0b\u5404\u9805\u6240\u5e36\u52d5\uff1a<\/span>(i)<\/span>\u8010\u8ce6\u5eb7\u00ae<\/span>\u7372\u7d0d\u5165\u4e2d\u570b\u570b\u5bb6\u91ab\u4fdd\u85e5\u54c1\u76ee\u9304\uff0c\u4e26\u5728\u4e9e\u6d32\u5730\u5340\u5168\u9762\u7372\u6279\uff0c\u672c\u516c\u53f8\u4e3b\u52d5\u589e\u52a0\u5728\u91ab\u7642\u6a5f\u69cb\u3001\u5b78\u8853\u63a8\u5ee3\u53ca\u91ab\u5b78\u6559\u80b2\u65b9\u9762\u7684\u8986\u84cb\uff1b\u53ca<\/span>(ii)<\/span>\u70ba\u652f\u6301\u4f9d\u5609\u00ae<\/span>\u7684\u5e02\u5834\u6ef2\u900f\u800c\u589e\u52a0\u7684\u5546\u696d\u6d3b\u52d5\u3002<\/span><\/p>\n

\u7d93\u71df\u958b\u652f\u7e3d\u984d\uff08\u5305\u62ec\u4e00\u822c\u53ca\u884c\u653f\u958b\u652f\u3001\u7814\u767c\u958b\u652f\u4ee5\u53ca\u5206\u92b7\u53ca\u92b7\u552e\u958b\u652f\uff09\u4f54\u92b7\u552e\u984d\u7684\u6bd4\u7387\u4e0b\u964d<\/span>40.1<\/span>\u500b\u767e\u5206\u9ede\uff0c\u53cd\u6620\u51fa\u696d\u52d9\u53ca\u7d93\u71df\u6548\u7387\u6709\u6240\u63d0\u5347\u4ee5\u53ca\u8cc7\u6e90\u7684\u96c6\u4e2d\u5206\u914d\u3002<\/span><\/p>\n

\u671f\u5167\u8667\u640d\u7531\u622a\u81f3<\/span>2024<\/span>\u5e74<\/span>6<\/span>\u6708<\/span>30<\/span>\u65e5\u6b62\u516d\u500b\u6708\u7684\u4eba\u6c11\u5e63<\/span>632.4<\/span>\u767e\u842c\u5143\u6e1b\u5c11\u4eba\u6c11\u5e63<\/span>382.6<\/span>\u767e\u842c\u5143\u81f3\u622a\u81f3<\/span>2025<\/span>\u5e74<\/span>6<\/span>\u6708<\/span>30<\/span>\u65e5\u6b62\u516d\u500b\u6708\u7684\u4eba\u6c11\u5e63<\/span>249.8<\/span>\u767e\u842c\u5143\u3002\u8a72\u6e1b\u5c11\u4e3b\u8981\u7531\u65bc\u7522\u54c1\u92b7\u552e\u5f37\u52c1\u3001\u696d\u52d9\u53ca\u7d93\u71df\u6548\u7387\u6709\u6240\u6539\u5584\uff0c\u4ee5\u53ca\u622a\u81f3<\/span>2024<\/span>\u5e74<\/span>6<\/span>\u6708<\/span>30<\/span>\u65e5\u6b62\u516d\u500b\u6708\u8207<\/span>mRNA COVID-19<\/span>\u75ab\u82d7\u6709\u95dc\u7684\u7121\u5f62\u8cc7\u7522\u7684\u4e00\u6b21\u6027\u3001\u975e\u7d93\u5e38\u6027\u6e1b\u503c\u8667\u640d\u3002<\/span><\/p>\n

\u622a\u81f3<\/span>2025<\/span>\u5e74<\/span>6<\/span>\u6708<\/span>30<\/span>\u65e5\uff0c\u73fe\u91d1\u53ca\u73fe\u91d1\u7b49\u50f9\u7269\u4ee5\u53ca\u9280\u884c\u5b58\u6b3e\u70ba\u4eba\u6c11\u5e63<\/span>1,585.9<\/span>\u767e\u842c\u5143\u3002<\/span><\/p>\n

\u975e\u570b\u969b\u8ca1\u52d9\u5831\u544a\u6e96\u5247\u6578\u5b57<\/span><\/p>\n

\u671f\u5167\u7d93\u8abf\u6574\u8667\u640d<\/span>[1]\u7531\u622a\u81f3<\/span>2024<\/span>\u5e74<\/span>6<\/span>\u6708<\/span>30<\/span>\u65e5\u6b62\u516d\u500b\u6708\u7684\u4eba\u6c11\u5e63<\/span>212.6<\/span>\u767e\u842c\u5143\u6536\u7a84\u81f3\u622a\u81f3<\/span>2025<\/span>\u5e74<\/span>6<\/span>\u6708<\/span>30<\/span>\u65e5\u6b62\u516d\u500b\u6708\u7684\u4eba\u6c11\u5e63<\/span>146.9<\/span>\u767e\u842c\u5143\uff0c\u6e1b\u5c11\u4eba\u6c11\u5e63<\/span>65.7<\/span>\u767e\u842c\u5143\uff0c\u4e3b\u8981\u662f\u5254\u9664\u7121\u5f62\u8cc7\u7522\u6e1b\u503c\u7684\u4e00\u6b21\u6027\u53ca\u975e\u7d93\u5e38\u6027\u8667\u640d\u3001\u4ee5\u80a1\u4efd\u70ba\u57fa\u790e\u7684\u85aa\u916c\u7684\u975e\u73fe\u91d1\u958b\u652f\u53ca\u7121\u5f62\u8cc7\u7522\u6524\u92b7\u3002<\/span><\/p>\n

\u6709\u95dc\u96f2\u9802\u65b0\u8000<\/span><\/p>\n

\u96f2\u9802\u65b0\u8000\u662f\u4e00\u5bb6\u5c08\u6ce8\u65bc\u5275\u65b0\u85e5\u548c\u75ab\u82d7\u7814\u767c\u3001\u81e8\u5e8a\u958b\u767c\u3001\u88fd\u9020\u53ca\u5546\u696d\u5316\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u6eff\u8db3\u4e9e\u6d32\u5e02\u5834\u5c1a\u672a\u6eff\u8db3\u7684\u91ab\u7642\u9700\u6c42\u3002\u96f2\u9802\u65b0\u8000\u7684\u7ba1\u7406\u5718\u968a\u5728\u4e2d\u570b\u53ca\u5168\u7403\u9818\u5148\u88fd\u85e5\u4f01\u696d\u5f9e\u4e8b\u904e\u9ad8\u8cea\u91cf\u7814\u767c\u3001\u81e8\u5e8a\u958b\u767c\u3001\u85e5\u653f\u4e8b\u52d9\u3001\u5316\u5b78\u5236\u9020\u8207\u63a7\u5236\uff08<\/span>CMC<\/span>\uff09\u3001\u696d\u52d9\u767c\u5c55\u548c\u5546\u696d\u5316\u904b\u71df\uff0c\u64c1\u6709\u6df1\u539a\u7684\u5c08\u9577\u548c\u8c50\u5bcc\u7684\u7d93\u9a57\u3002\u96f2\u9802\u65b0\u8000\u5df2\u6253\u9020\u591a\u6b3e\u75be\u75c5\u9996\u5275\u6216\u8005\u540c\u985e\u6700\u4f73\u7684\u85e5\u7269\u7d44\u5408\u3002\u516c\u53f8\u7684\u6cbb\u7642\u9818\u57df\u5305\u62ec\u814e\u79d1\u75be\u75c5\u3001\u611f\u67d3\u6027\u548c\u50b3\u67d3\u6027\u75be\u75c5\u3001\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3002\u6709\u95dc\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\u516c\u53f8\u7db2\u7ad9\uff1a<\/span>www.everestmedicines.com<\/a><\/span>\u3002<\/span><\/p>\n

\u524d\u77bb\u6027\u8072\u660e<\/span><\/p>\n

\u672c\u65b0\u805e\u7a3f\u6240\u767c\u5e03\u7684\u4fe1\u606f\u4e2d\u53ef\u80fd\u6703\u5305\u542b\u67d0\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\uff0c\u4e43\u57fa\u65bc\u672c\u516c\u53f8\u6216\u7ba1\u7406\u5c64\u5728\u505a\u51fa\u8868\u8ff0\u6642\u5c0d\u516c\u53f8\u696d\u52d9\u904b\u71df\u60c5\u6cc1\u53ca\u8ca1\u52d9\u72c0\u6cc1\u7684\u73fe\u6709\u770b\u6cd5\u3001\u76f8\u4fe1\u3001\u548c\u73fe\u6709\u9810\u671f\uff0c\u53ef\u80fd\u6703\u4f7f\u7528\u300c\u5c07\u300d\u3001\u300c\u9810\u671f\u300d\u3001\u300c\u9810\u6e2c\u300d\u3001\u300c\u671f\u671b\u300d\u3001\u300c\u6253\u7b97\u300d\u3001\u300c\u8a08\u5283\u300d\u3001\u300c\u76f8\u4fe1\u300d\u3001\u300c\u9810\u4f30\u300d\u3001\u300c\u78ba\u4fe1\u300d\u53ca\u5176\u4ed6\u985e\u4f3c\u8a5e\u8a9e\u9032\u884c\u8868\u8ff0\u3002\u9019\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u4e26\u975e\u5c0d\u672a\u4f86\u696d\u7e3e\u7684\u4fdd\u8b49\uff0c\u6703\u53d7\u5230\u98a8\u96aa\u3001\u4e0d\u78ba\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u97ff\uff0c\u6709\u4e9b\u4e43\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u7bc4\u570d\uff0c\u96e3\u4ee5\u9810\u8a08\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u5011\u7684\u696d\u52d9\u3001\u7af6\u722d\u74b0\u5883\u3001\u653f\u6cbb\u3001\u7d93\u6fdf\u3001\u6cd5\u5f8b\u548c\u793e\u6703\u60c5\u6cc1\u7684\u672a\u4f86\u8b8a\u5316\u53ca\u767c\u5c55\u7b49\u5404\u7a2e\u56e0\u7d20\u53ca\u5047\u8a2d\u7684\u5f71\u97ff\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u6703\u8207\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u6578\u64da\u6709\u8f03\u5927\u5dee\u5225\u3002\u672c\u516c\u53f8\u53ca\u5404\u9644\u5c6c\u516c\u53f8\u3001\u5404\u4f4d\u8463\u4e8b\u3001\u7ba1\u7406\u4eba\u54e1\u3001\u9867\u554f\u53ca\u4ee3\u7406\u672a\u66fe\u4e14\u6982\u4e0d\u627f\u64d4\u66f4\u65b0\u8a72\u7a3f\u4ef6\u6240\u8f09\u524d\u77bb\u6027\u8868\u8ff0\u4ee5\u53cd\u6620\u5728\u672c\u65b0\u805e\u7a3f\u767c\u5e03\u723e\u65e5\u5f8c\u6700\u65b0\u4fe1\u606f\u3001\u672a\u4f86\u9805\u76ee\u6216\u60c5\u5f62\u7684\u4efb\u4f55\u7fa9\u52d9\uff0c\u9664\u975e\u6cd5\u5f8b\u8981\u6c42\u3002<\/span><\/p>\n

\n

[1] \u671f\u5167\u7d93\u8abf\u6574\u8667\u640d\u6307\u672a\u8a08\u53ca\u82e5\u5e72\u975e\u73fe\u91d1\u9805\u76ee\u53ca\u4e00\u6b21\u6027\u4e8b\u4ef6\u5f71\u97ff\u7684\u672c\u516c\u53f8\u6b0a\u76ca\u6301\u6709\u4eba\u61c9\u4f54\u671f\u5167\u8667\u640d\uff0c\u8a72\u7b49\u975e\u73fe\u91d1\u9805\u76ee\u53ca\u4e00\u6b21\u6027\u4e8b\u4ef6\u6307\u6309\u516c\u5141\u503c\u8a08\u5165\u640d\u76ca\u7684\u91d1\u878d\u8cc7\u7522\u516c\u5141\u503c\u8b8a\u52d5\u8667\u640d\u3001\u512a\u5148\u80a1\u516c\u5141\u503c\u8b8a\u52d5\u7522\u751f\u7684\u8667\u640d\uff08\u6309\u516c\u5141\u503c\u8a08\u5165\u640d\u76ca\u8a08\u91cf\u7684\u975e\u6d41\u52d5\u91d1\u878d\u8ca0\u50b5\uff09\u3001\u4ee5\u80a1\u4efd\u70ba\u57fa\u790e\u7684\u85aa\u916c\u958b\u652f\u3001\u7121\u5f62\u8cc7\u7522\u7684\u6e1b\u503c\u8667\u640d\u53ca\u7121\u5f62\u8cc7\u7522\u6524\u92b7\u3002\u6709\u95dc\u975e\u570b\u969b\u8ca1\u52d9\u5831\u544a\u6e96\u5247\u8a08\u91cf\u7684\u8a08\u7b97\u65b9\u6cd5\u53ca\u5c0d\u8cec\uff0c\u8acb\u53c3\u95b1\u8ca1\u5831\u300c\u8ca1\u52d9\u56de\u9867\u300d\u7de8\u865f14\u4e00\u6bb5\u3002<\/span><\/p>\n<\/div>\n

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