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\u95dc\u65bc\u4ee3\u8b1d\u76f8\u95dc\u8102\u80aa\u809d\u75c5\uff08 MAFLD\uff09 <\/p>\n

MAFLD\u662f\u5168\u7403\u6700\u5e38\u898b\u7684\u6162\u6027\u809d\u75c5\uff0c\u5168\u7403MAFLD\u7e3d\u9ad4\u60a3\u75c5\u7387\u4f30\u8a08\u70ba32.4%\uff0c\u4e14\u60a3\u75c5\u7387\u9010\u5e74\u5347\u9ad8\u3002\u80a5\u80d6\u4f5c\u70baMAFLD\u7684\u5371\u96aa\u56e0\u7d20\u4e4b\u4e00\uff0c\u5168\u7403\u80a5\u80d6\u4eba\u7fa4\u4e2d\u7684MAFLD\u60a3\u75c5\u7387\u9054\u523075.3%\u3002\u5728\u4e2d\u570b\uff0cMAFLD\u4e14\u5df2\u7d93\u53d6\u4ee3\u75c5\u6bd2\u6027\u809d\u708e\u6210\u70ba\u4e2d\u570b\u7b2c\u4e00\u5927\u6162\u6027\u809d\u75c5\u3002\u4e2d\u570b\u80a5\u80d6\u4eba\u7fa4MAFLD\u60a3\u75c5\u7387\u70ba81.8%[1]\u3002\u540c\u6642\uff0c\u4e2d\u570bMAFLD\u5e74\u767c\u75c5\u7387\u5728\u6b63\u5e38\u4eba\u7fa4\u6216\u80a5\u80d6\u4eba\u7fa4\u4e2d\u5747\u70ba\u5168\u7403\u6700\u9ad8\u3002<\/p>\n

MAFLD\u6cbb\u7642\u76ee\u6a19\u5305\u62ec\u6e1b\u5c11\u9ad4\u8cea\u91cf\u548c\u8170\u570d\u3001\u6539\u5584\u80f0\u5cf6\u7d20\u62b5\u6297\u3001\u9632\u6cbb\u4ee3\u8b1d\u76f8\u95dc\u7d9c\u5408\u5f81\u3001\u9006\u8f49\u7e96\u7dad\u5316\u7b49\u7b49\uff0c\u8207\u80a5\u80d6\u60a3\u8005\u7684\u6cbb\u7642\u539f\u5247\u5b58\u5728\u76f8\u4f3c\u4e4b\u8655\u3002\u5c0d\u65bc\u8d85\u91cd\u6216\u80a5\u80d6\u5408\u4f75MAFLD\u7684\u60a3\u8005\uff0c\u5728\u751f\u6d3b\u65b9\u5f0f\u5e72\u9810\u7684\u57fa\u790e\u4e0a\u8f14\u4ee5\u85e5\u7269\u6cbb\u7642\u662f\u5be6\u73fe\u6709\u6548\u6e1b\u91cd\u3001\u6539\u5584\u5408\u4f75\u75c7\u4ee5\u53ca\u63d0\u9ad8\u751f\u6d3b\u8cea\u91cf\u7684\u512a\u9078\u65b9\u6848\u3002<\/p>\n

\u95dc\u65bc\u746a\u4ed5\u5ea6\u80bd\uff08 IBI362\uff09 <\/p>\n

\u746a\u4ed5\u5ea6\u80bd\uff08IBI362\uff09\u662f\u4fe1\u9054\u751f\u7269\u8207\u79ae\u4f86\u88fd\u85e5\u5171\u540c\u63a8\u9032\u7684\u4e00\u6b3e\u80f0\u9ad8\u8840\u7cd6\u7d20\uff08GCG\uff09\/\u80f0\u9ad8\u8840\u7cd6\u7d20\u6a23\u80bd-1\uff08GLP-1\uff09\u96d9\u53d7\u9ad4\u6fc0\u52d5\u5291\u3002\u4f5c\u70ba\u4e00\u7a2e\u54fa\u4e73\u52d5\u7269\u80c3\u6ccc\u9178\u8abf\u7bc0\u7d20\uff08OXM\uff09\u985e\u4f3c\u7269\uff0c\u746a\u4ed5\u5ea6\u80bd\u9664\u4e86\u901a\u904e\u6fc0\u52d5GLP-1R\u4fc3\u9032\u80f0\u5cf6\u7d20\u5206\u6ccc\u3001\u964d\u4f4e\u8840\u7cd6\u548c\u6e1b\u8f15\u9ad4\u91cd\u5916\uff0c\u9084\u53ef\u901a\u904e\u6fc0\u52d5GCGR\u589e\u52a0\u80fd\u91cf\u6d88\u8017\u589e\u5f37\u6e1b\u91cd\u7642\u6548\uff0c\u540c\u6642\u6539\u5584\u809d\u81df\u8102\u80aa\u4ee3\u8b1d\u3002\u746a\u4ed5\u5ea6\u80bd\u5df2\u5728\u591a\u9805\u81e8\u5e8a\u7814\u7a76\u4e2d\u5c55\u73fe\u51fa\u512a\u79c0\u7684\u6e1b\u91cd\u548c\u964d\u7cd6\u7642\u6548\uff0c\u4ee5\u53ca\u964d\u4f4e\u8170\u570d\u3001\u8840\u8102\u3001\u8840\u58d3\u3001\u8840\u5c3f\u9178\u3001\u809d\u9176\u53ca\u809d\u81df\u8102\u80aa\u542b\u91cf\uff0c\u4ee5\u53ca\u6539\u5584\u80f0\u5cf6\u7d20\u654f\u611f\u6027\uff0c\u5e36\u4f86\u591a\u91cd\u4ee3\u8b1d\u7372\u76ca\u3002<\/p>\n

\u746a\u4ed5\u5ea6\u80bd\u7576\u524d\u5171\u6709\u5169\u9805NDA\u7372NMPA\u53d7\u7406\u5be9\u8a55\uff0c\u5305\u62ec\uff1a<\/p>\n

\u7528\u65bc\u6210\u4eba\u80a5\u80d6\u6216\u8d85\u91cd\u60a3\u8005\u7684\u9577\u671f\u9ad4\u91cd\u63a7\u5236\uff1b \u7528\u65bc\u6210\u4eba2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u8840\u7cd6\u63a7\u5236\u3002 <\/p>\n

\u746a\u4ed5\u5ea6\u80bd\u7576\u524d\u5171\u958b\u5c55\u4e86\u516d\u9805III\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u5305\u62ec\uff1a<\/p>\n

\u5728\u4e2d\u570b\u8d85\u91cd\u6216\u80a5\u80d6\u53d7\u8a66\u8005\u4e2d\u958b\u5c55\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff08GLORY-1\uff09\uff1b \u5728\u4e2d\u570b\u4e2d\u91cd\u5ea6\u80a5\u80d6\u53d7\u8a66\u8005\u4e2d\u958b\u5c55\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff08GLORY-2\uff09\uff1b \u5728\u4e2d\u570b\u8d85\u91cd\u6216\u80a5\u80d6\u5408\u4f75MAFLD\u53d7\u8a66\u8005\u4e2d\u958b\u5c55\u7684\u5c0d\u6bd4\u746a\u4ed5\u5ea6\u80bd\u548c\u53f8\u7f8e\u683c\u9b6f\u80bd\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff08GLORY-3\uff09; \u5728\u521d\u6cbb\u7684\u4e2d\u570b2\u578b\u7cd6\u5c3f\u75c5\u53d7\u8a66\u8005\u4e2d\u958b\u5c55\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff08DREAMS-1\uff09\uff1b \u5728\u53e3\u670d\u85e5\u7269\u6cbb\u7642\u8840\u7cd6\u63a7\u5236\u4e0d\u4f73\u7684\u4e2d\u570b2\u578b\u7cd6\u5c3f\u75c5\u53d7\u8a66\u8005\u4e2d\u958b\u5c55\u7684\u5c0d\u6bd4\u746a\u4ed5\u5ea6\u80bd\u548c\u5ea6\u62c9\u7cd6\u80bd\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff08DREAMS-2\uff09\uff1b \u5728\u4e2d\u570b2\u578b\u7cd6\u5c3f\u75c5\u5408\u4f75\u80a5\u80d6\u7684\u53d7\u8a66\u8005\u4e2d\u958b\u5c55\u7684\u5c0d\u6bd4\u746a\u4ed5\u5ea6\u80bd\u548c\u53f8\u7f8e\u683c\u9b6f\u80bd\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff08DREAMS-3\uff09\u3002 <\/p>\n

\u5176\u4e2d\uff0cGLORY-1\u3001DREAMS-1\u548cDREAMS-2\u7814\u7a76\u5747\u5df2\u9054\u6210\u7d42\u9ede\u3002<\/p>\n

\u6b64\u5916\uff0c\u746a\u4ed5\u5ea6\u80bd\u7684\u591a\u9805\u65b0\u81e8\u5e8a\u7814\u7a76\u8a08\u5283\u555f\u52d5\uff0c\u5176\u4e2d\u5305\u62ec\u6cbb\u7642\u9752\u5c11\u5e74\u80a5\u80d6\u548c\u963b\u585e\u6027\u7761\u7720\u547c\u5438\u66ab\u505c\uff08OSA\uff09\u7684\u5169\u9805III\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u4ee5\u53ca\u6cbb\u7642\u4ee3\u8b1d\u76f8\u95dc\u8102\u80aa\u6027\u809d\u708e\uff08MASH\uff09\u3001\u5c04\u8840\u5206\u6578\u4fdd\u7559\u5fc3\u529b\u8870\u7aed\uff08HFpEF\uff09\u7b49\u65b0\u81e8\u5e8a\u7814\u7a76\u3002<\/p>\n

\u95dc\u65bc\u4fe1\u9054\u751f\u7269 <\/p>\n

\u300c\u59cb\u65bc\u4fe1\uff0c\u9054\u65bc\u884c\u300d\uff0c\u958b\u767c\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8cea\u91cf\u751f\u7269\u85e5\uff0c\u662f\u4fe1\u9054\u751f\u7269\u7684\u4f7f\u547d\u548c\u76ee\u6a19\u3002\u4fe1\u9054\u751f\u7269\u6210\u7acb\u65bc2011\u5e74\uff0c\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u7684\u5275\u65b0\u85e5\u7269\uff0c\u8b93\u6211\u5011\u7684\u5de5\u4f5c\u60e0\u53ca\u66f4\u591a\u7684\u751f\u547d\u3002\u516c\u53f8\u5df2\u670915\u500b\u7522\u54c1\u7372\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c\u5b83\u5011\u5206\u5225\u662f\u4fe1\u8fea\u5229\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u4f2f\u8212\u00ae\uff09\uff0c\u8c9d\u4f10\u73e0\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u6538\u540c\u00ae\uff09\uff0c\u963f\u9054\u6728\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u8607\u7acb\u4fe1\u00ae\uff09\uff0c\u5229\u59a5\u6614\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u4f2f\u83ef\u00ae\uff09\uff0c\u4f69\u7c73\u66ff\u5c3c\u7247\uff08\u9054\u4f2f\u5766\u00ae\uff09\uff0c\u5967\u96f7\u5df4\u66ff\u5c3c\u7247\uff08\u8010\u7acb\u514b\u00ae\uff09\uff0c \u96f7\u83ab\u897f\u5c24\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u5e0c\u5189\u64c7\u00ae\uff09\uff0c\u585e\u666e\u66ff\u5c3c\u81a0\u56ca\uff08\u777f\u59a5\u00ae\uff09\uff0c\u4f0a\u57fa\u5967\u4f96\u8cfd\u6ce8\u5c04\u6db2\uff08\u798f\u53ef\u8607\u00ae\uff09\uff0c\u6258\u840a\u897f\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u4fe1\u5fc5\u6a02\u00ae\uff09\uff0c\u6c1f\u6fa4\u96f7\u585e\u7247\uff08\u9054\u4f2f\u7279\u00ae\uff09\uff0c\u5339\u59a5\u5e03\u66ff\u5c3c\u7247\uff08\u6377\u5e15\u529b\u00ae\uff09\uff0c\u5df1\u4e8c\u9178\u4ed6\u96f7\u66ff\u5c3c\u81a0\u56ca\uff08\u9054\u4f2f\u6a02\u00ae\uff09\uff0c\u5229\u5384\u66ff\u5c3c\u7247\uff08\u5967\u58f9\u65b0\u00ae\uff09\u548c\u66ff\u59a5\u5c24\u55ae\u6297N01\u6ce8\u5c04\u6db2\uff08\u4fe1\u5fc5\u654f\u00ae\uff09\u3002\u76ee\u524d\uff0c\u540c\u6642\u9084\u67093\u500b\u54c1\u7a2e\u5728NMPA\u5be9\u8a55\u4e2d\uff0c4\u500b\u65b0\u85e5\u5206\u5b50\u9032\u5165III\u671f\u6216\u95dc\u9375\u6027\u81e8\u5e8a\u7814\u7a76\uff0c\u53e6\u5916\u9084\u670915\u500b\u65b0\u85e5\u54c1\u7a2e\u5df2\u9032\u5165\u81e8\u5e8a\u7814\u7a76\u3002<\/p>\n

\u516c\u53f8\u5df2\u8207\u79ae\u4f86\u3001\u7f85\u6c0f\u3001\u8cfd\u8afe\u83f2\u3001Adimab\u3001Incyte\u548cMD Anderson \u764c\u75c7\u4e2d\u5fc3\u7b49\u570b\u969b\u5408\u4f5c\u65b9\u9054\u621030\u591a\u9805\u6230\u7565\u5408\u4f5c\u3002\u4fe1\u9054\u751f\u7269\u5728\u4e0d\u65b7\u81ea\u7814\u5275\u65b0\u85e5\u7269\u3001\u8b00\u6c42\u81ea\u8eab\u767c\u5c55\u7684\u540c\u6642\uff0c\u79c9\u627f\u7d93\u6fdf\u5efa\u8a2d\u4ee5\u4eba\u6c11\u70ba\u4e2d\u5fc3\u7684\u767c\u5c55\u601d\u60f3\u3002\u591a\u5e74\u4f86\uff0c\u59cb\u7d42\u5fc3\u61f7\u79d1\u5b78\u5584\u5ff5\uff0c\u5805\u5b88\u300c\u4ee5\u60a3\u8005\u70ba\u4e2d\u5fc3\u300d\uff0c\u5fc3\u7e6b\u60a3\u8005\u4e26\u95dc\u6ce8\u60a3\u8005\u5bb6\u5ead\uff0c\u7a4d\u6975\u5c65\u884c\u793e\u6703\u8cac\u4efb\u3002\u516c\u53f8\u9678\u7e8c\u767c\u8d77\u3001\u53c3\u8207\u4e86\u591a\u9805\u85e5\u54c1\u516c\u76ca\u63f4\u52a9\u9805\u76ee\uff0c\u8b93\u8d8a\u4f86\u8d8a\u591a\u7684\u60a3\u8005\u80fd\u5920\u5f97\u76ca\u65bc\u751f\u547d\u79d1\u5b78\u7684\u9032\u6b65\uff0c\u8cb7\u5f97\u5230\u3001\u7528\u5f97\u8d77\u9ad8\u8cea\u91cf\u7684\u751f\u7269\u85e5\u3002\u622a\u81f3\u76ee\u524d\uff0c\u4fe1\u9054\u751f\u7269\u60a3\u8005\u63f4\u52a9\u9805\u76ee\u5df2\u60e0\u53ca20\u9918\u842c\u666e\u901a\u60a3\u8005\uff0c\u85e5\u7269\u6350\u8d08\u7e3d\u50f9\u503c36\u5104\u5143\u4eba\u6c11\u5e63\u3002\u4fe1\u9054\u751f\u7269\u5e0c\u671b\u548c\u5927\u5bb6\u4e00\u8d77\u52aa\u529b\uff0c\u63d0\u9ad8\u4e2d\u570b\u751f\u7269\u88fd\u85e5\u7522\u696d\u7684\u767c\u5c55\u6c34\u5e73\uff0c\u4ee5\u6eff\u8db3\u767e\u59d3\u7528\u85e5\u53ef\u53ca\u6027\u548c\u4eba\u6c11\u5c0d\u751f\u547d\u5065\u5eb7\u7f8e\u597d\u9858\u671b\u7684\u8ffd\u6c42\u3002<\/p>\n

\u8a73\u60c5\u8acb\u8a2a\u554f\u516c\u53f8\u7db2\u7ad9\uff1awww.innoventbio.com<\/a>\u6216\u516c\u53f8\u9818\u82f1\u8cec\u865f www.linkedin.com\/<\/a> \u00a0<\/p>\n

\n

\u8072\u660e\uff1a 1.\u4fe1\u9054\u751f\u7269\u4e0d\u63a8\u85a6\u672a\u7372\u6279\u7684\u85e5\u54c1\/\u9069\u61c9\u75c7\u7684\u4f7f\u7528\u3002 <\/span> <\/p>\n

2.\u96f7\u83ab\u897f\u5c24\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u5e0c\u5189\u64c7\u00ae\uff09\uff0c\u585e\u666e\u66ff\u5c3c\u81a0\u56ca\uff08\u777f\u59a5\u00ae\uff09\u548c\u5339\u59a5\u5e03\u66ff\u5c3c\u7247\uff08\u6377\u5e15\u529b\u00ae\uff09\u7531\u79ae\u4f86\u516c\u53f8\u7814\u767c <\/span> <\/p>\n<\/div>\n

\u00a0<\/p>\n

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[1] Chen K, Shen Z, Gu W, Lyu Z, Qi X, Mu Y, Ning Y; Meinian Investigator Group. Prevalence of obesity and associated complications in China: A cross-sectional, real-world study in 15.8 million adults. Diabetes Obes Metab. 2023 Nov;25\uff0811\uff09:3390-3399.<\/span> <\/p>\n

[2]\u00a0Pan XF, Wang L, Pan A. Epidemiology and determinants of obesity in China. Lancet Diabetes Endocrinol 2021; 9: 373\u201392.<\/span> <\/p>\n

[3] Institute for Health Metrics and Evaluation. Global Health Data Exchange. GBD results tool.http:\/\/ghdx.healthdata.org\/gbd-resultstool \u00a0\uff08accessed Jan 10, 2021\uff09.<\/span> <\/p>\n<\/div>\n

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