{"id":25823,"date":"2025-04-28T00:00:00","date_gmt":"2025-04-27T16:00:00","guid":{"rendered":"https:\/\/www.franchise.com.hk\/2025-aacr-%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%a4%9a%e9%a0%85%e5%89%b5%e6%96%b0%e9%9b%99%e6%8a%97%e3%80%81%e4%b8%89%e6%8a%97%e5%8f%8a%e9%9b%99%e6%8a%97adc%e8%87%a8%e5%ba%8a%e5%89%8d%e6%95%b8\/25823"},"modified":"2025-04-28T00:00:00","modified_gmt":"2025-04-27T16:00:00","slug":"2025-aacr-%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%a4%9a%e9%a0%85%e5%89%b5%e6%96%b0%e9%9b%99%e6%8a%97%e3%80%81%e4%b8%89%e6%8a%97%e5%8f%8a%e9%9b%99%e6%8a%97adc%e8%87%a8%e5%ba%8a%e5%89%8d%e6%95%b8","status":"publish","type":"post","link":"https:\/\/www.franchise.com.hk\/zh-hans\/2025-aacr-%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%a4%9a%e9%a0%85%e5%89%b5%e6%96%b0%e9%9b%99%e6%8a%97%e3%80%81%e4%b8%89%e6%8a%97%e5%8f%8a%e9%9b%99%e6%8a%97adc%e8%87%a8%e5%ba%8a%e5%89%8d%e6%95%b8\/25823","title":{"rendered":"2025 AACR | \u4fe1\u9054\u751f\u7269\u591a\u9805\u5275\u65b0\u96d9\u6297\u3001\u4e09\u6297\u53ca\u96d9\u6297ADC\u81e8\u5e8a\u524d\u6578\u64da\u4eae\u76f8"},"content":{"rendered":"

\u7f8e\u570b\u820a\u91d1\u5c71\u548c\u4e2d\u570b\u8607\u5dde<\/span> 2025\u5e744\u670828\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u80a1\u7968\u4ee3\u78bc\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u53ca\u5fc3\u8840\u7ba1\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u5275\u65b0\u85e5\u7269\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u5ba3\u4f48\u5728 2025 \u5e74\u7f8e\u570b\u764c\u75c7\u7814\u7a76\u5354\u6703\uff08AACR\uff09\u5e74\u6703\u4e0a\u516c\u4f48\u591a\u9805\u6700\u65b0\u81e8\u5e8a\u524d\u6578\u64da\uff0c\u5305\u62ec\u516c\u53f8\u65d7\u4e0b\u4e00\u7cfb\u5217\u96d9\u6297\u3001\u4e09\u6297\u53ca\u96d9\u6297\u9ad4\u5076\u806f\u85e5\u7269\uff08ADC\uff09\u816b\u7624\u7ba1\u7dda\u3002\u672c\u5c46 AACR \u5e74\u6703\u65bc\u7576\u5730\u6642\u95932025\u5e744\u670825\u65e5-30\u65e5\u5728\u7f8e\u570b\u829d\u52a0\u54e5\u8209\u8fa6\u3002<\/p>\n

\u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\u816b\u7624\u751f\u7269\u5b78\u8207 ADC\u85e5\u7269\u7814\u7a76\u526f\u7e3d\u88c1\u4f55\u958b\u5091\u535a\u58eb\u8868\u793a\uff1a\u300c\u96a8\u8457\u570b\u6e05\u9662\u6280\u8853\u5e73\u53f0\u7684\u62d3\u5c55\u5347\u7d1a\uff0c\u4fe1\u9054\u751f\u7269\u7684\u5168\u7403\u7814\u767c\u80fd\u529b\u5df2\u9054\u5230\u65b0\u9ad8\u5ea6\uff0c\u9032\u4e00\u6b65\u589e\u5f37\u4e86\u6211\u5011\u5728\u570b\u969b\u751f\u7269\u88fd\u85e5\u9818\u57df\u7684\u7af6\u722d\u5730\u4f4d\uff0c\u4e5f\u63d0\u5347\u4e86\u6211\u5011\u8a2d\u8a08\u548c\u958b\u767c\u5177\u6709\u5168\u7403\u5f71\u97ff\u529b\u7684\u5275\u65b0\u5019\u9078\u85e5\u7269\u7684\u80fd\u529b\u3002\u5f88\u9ad8\u8208\u5728\u672c\u6b21AACR\u5e74\u6703\u4e0a\u570b\u6e05\u9662\u5c55\u793a\u591a\u9805\u81e8\u5e8a\u524d\u7814\u7a76\u6210\u679c\uff0c\u5305\u62ec\u591a\u500b\u5168\u7403\u9996\u5275\u7684\u96d9\u6297\u3001\u591a\u6297\u53caADC\u7684\u9996\u6b21\u4eae\u76f8\uff0c\u9019\u4e0d\u50c5\u5c55\u73fe\u4e86\u6211\u5011\u7684\u7814\u767c\u5be6\u529b\uff0c\u4e5f\u9032\u4e00\u6b65\u5805\u5b9a\u4e86\u6211\u5011\u5728\u5168\u7403\u7bc4\u570d\u5167\u70ba\u60a3\u8005\u63d0\u4f9b\u7a81\u7834\u6027\u6cbb\u7642\u9078\u64c7\u7684\u4fe1\u5fc3\u3002\u6211\u5011\u5c07\u6301\u7e8c\u805a\u7126\u5275\u65b0\uff0c\u63a2\u7d22\u7cbe\u6e96\u9776\u9ede\u7684\u512a\u5316\u8207\u65b0\u6a5f\u5236\uff0c\u70ba\u96e3\u6cbb\u6027\u75be\u75c5\u63d0\u4f9b\u7a81\u7834\u6027\u89e3\u6c7a\u65b9\u6848\uff0c\u78ba\u4fdd\u5168\u7403\u66f4\u591a\u60a3\u8005\u80fd\u5920\u7372\u5f97\u524d\u6cbf\u6cbb\u7642\u6280\u8853\u5e36\u4f86\u7684\u76ca\u8655\u3002\u300d<\/p>\n

\u6458\u8981\u4eae\u9ede\u7bc0\u9078\u5982\u4e0b\uff1a<\/p>\n

\u91cd\u78c5\u7814\u7a76\uff08 Late-Breaking Research\uff09
\u6a19\u984c\uff1a IAR037\uff0c\u4e00\u7a2e\u65b0\u578bCD40\/PD-L1\u96d9\u7279\u7570\u6027\u6297\u9ad4\u7528\u65bc\u6cbb\u7642\u514d\u75ab\u6aa2\u67e5\u9ede\u6291\u5236\u5291\u8010\u85e5\u665a\u671f\u5be6\u9ad4\u7624\u7684\u81e8\u5e8a\u524d\u6578\u64da
\u6458\u8981\u865f\uff1aLB139
\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831
\u6642\u9593\uff1a2025\u5e744\u670828\u65e5\uff08\u661f\u671f\u4e00\uff09 9\uff1a00 AM \u2013 12\uff1a00 PM \uff08\u7576\u5730\u6642\u9593\uff09
\u5730\u9ede\uff1aPoster Section 52<\/p>\n

IAR037\u662f\u4e00\u7a2e\u65b0\u578bCD40\/PD-L1\u96d9\u7279\u7570\u6027\u6297\u9ad4\uff0c\u53ef\u540c\u6642\u6fc0\u6d3bCD40\u901a\u8def\u4e26\u963b\u65b7PD-1\/L1\u76f8\u4e92\u4f5c\u7528\uff0c\u5728PD-1\u8010\u85e5\u7684\u540c\u6e90\u5c0f\u9f20\u6a21\u578b\u4e2d\u986f\u793a\u51fa\u5f37\u6548\u6297\u816b\u7624\u6d3b\u6027\uff0c\u4e26\u8207PD-1\/IL-2\u03b1-bias\u878d\u5408\u86cb\u767dIBI363\u7522\u751f\u5354\u540c\u6548\u61c9\u3002\u81e8\u5e8a\u524d\u7814\u7a76\u986f\u793a\u5176\u5177\u6709\u816b\u7624\u7279\u7570\u6027\u514d\u75ab\u6fc0\u6d3b\u4f5c\u7528\uff0c\u7cfb\u7d71\u526f\u4f5c\u7528\u6975\u5c0f\uff0c\u4e26\u5728\u98df\u87f9\u7334\u4e2d\u5c55\u73fe\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u3002<\/p>\n

IAR037\u70ba\u514d\u75ab\u6aa2\u67e5\u9ede\u6291\u5236\u5291\uff08ICI\uff09\u8010\u85e5\u7684\u665a\u671f\u5be6\u9ad4\u7624\u63d0\u4f9b\u4e86\u5275\u65b0\u6cbb\u7642\u65b9\u6848\uff0c\u76ee\u524dIND\u6b63\u5728\u63a8\u9032\u4e2d\u3002<\/p>\n

\u6a19\u984c\uff1a IBI3010\uff0c\u4e00\u7a2e\u9776\u5411FR\u03b1\u7684\u96d9\u8868\u4f4dADC\uff0c\u7528\u65bc\u6cbb\u7642FR\u03b1\u8868\u9054\u816b\u7624\u7684\u81e8\u5e8a\u524d\u7279\u6027\u7814\u7a76
\u6458\u8981\u865f\uff1aLB222
\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831
\u6642\u9593\uff1a2025\u5e744\u670828\u65e5\uff08\u661f\u671f\u4e00\uff09 2\uff1a00 PM \u2013 5\uff1a00 PM \uff08\u7576\u5730\u6642\u9593\uff09
\u5730\u9ede\uff1aPoster Section 53<\/p>\n

IBI3010\u662f\u4e00\u6b3e\u9776\u5411FR\u03b1\u7684\u96d9\u8868\u4f4dADC\uff0cpayload\u70ba\u65b0\u578b\u62d3\u64b2\u7570\u69cb\u9176I\u6291\u5236\u5291NT1\uff08DAR8\uff09\u3002\u5176\u96d9\u8868\u4f4d\u8a2d\u8a08\u986f\u8457\u589e\u5f37\u4e86\u816b\u7624\u7d50\u5408\u8207\u5167\u541e\u3002<\/p>\n

\u9ad4\u5916\u5be6\u9a57\u986f\u793a\uff0cIBI3010\u8f03Mirvetuximab Soravtansine\uff08IMGN853\uff09\u5177\u6709\u66f4\u512a\u7684\u7d30\u80de\u6bba\u50b7\u6bd2\u6027\u53ca\u65c1\u89c0\u8005\u6548\u61c9\u3002\u5728FR\u03b1\u8868\u9054\u7684CDX\u6a21\u578b\u4e2d\uff0cIBI3010\u5c55\u73fe\u51fa\u66f4\u512a\u7570\u7684\u6297\u816b\u7624\u6d3b\u6027\uff0c\u5c24\u5176\u5728\u4f4eFR\u03b1\u8868\u9054\u7684\u6a21\u578b\u4e2d\u512a\u52e2\u66f4\u70ba\u986f\u8457\u3002\u98df\u87f9\u7334GLP\u6bd2\u7406\u7814\u7a76\u986f\u793a\uff0c\u5176\u6700\u9ad8\u975e\u56b4\u91cd\u6bd2\u6027\u5291\u91cf\uff08HNSTD\uff09\u70ba60mg\/kg\u3002<\/p>\n

\u4e0a\u8ff0\u6578\u64da\u652f\u6301IBI3010\u63a8\u9032\u81e8\u5e8a\u7814\u7a76\uff0c\u8a55\u4f30\u5176\u4f5c\u70baADC\u7642\u6cd5\u6cbb\u7642FR\u03b1\u967d\u6027\u5be6\u9ad4\u7624\uff08\u7279\u5225\u662f\u4f4e\u8868\u9054\u4e9e\u578b\uff09\u7684\u6f5b\u529b\u3002<\/p>\n

\u58c1\u5831\u5c55\u793a
\u6703\u8b70\u985e\u5225\uff1a\u5be6\u9a57\u8207\u5206\u5b50\u6cbb\u7642\u5b78 – \u764c\u75c7\u751f\u5316\u8abf\u7bc0\u5291\/\u5206\u5316\u6cbb\u7642\u7b56\u7565
\u6a19\u984c\uff1aIBI3014\uff0c\u4e00\u7a2e\u5728\u55ae\u4e00\u5206\u5b50\u4e2d\u6574\u5408ADC\u6bba\u50b7\u4f5c\u7528\u8207\u6aa2\u67e5\u9ede\u963b\u65b7\u529f\u80fd\u7684TROP2\u00d7PD-L1\u96d9\u6297ADC\uff0c\u5728\u81e8\u5e8a\u524d\u6a21\u578b\u4e2d\u5c55\u73fe\u51fa\u826f\u597d\u7684\u7642\u6548\u8207\u5b89\u5168\u6027
\u6458\u8981\u865f\uff1a344
\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831
\u6642\u9593\uff1a2025\u5e744\u670827\u65e5\uff08\u661f\u671f\u65e5\uff092:00 PM – 5:00 PM\uff08\u7576\u5730\u6642\u9593\uff09
\u5730\u9ede\uff1aPoster Section 16<\/p>\n

IBI3014 \u662f\u4e00\u6b3e\u9776\u5411TROP2\u548cPD-L1\u7684\u96d9\u7279\u7570\u6027ADC\uff0c\u6574\u5408\u4e86TROP2\u4ecb\u5c0e\u7684\u816b\u7624\u6bba\u50b7\u8207PD-L1\u514d\u75ab\u6aa2\u67e5\u9ede\u963b\u65b7\uff0c\u589e\u5f37\u4e86\u514d\u75ab\u539f\u6027\u7d30\u80de\u6b7b\u4ea1\uff08ICD\uff09\u548cT\u7d30\u80de\u6d78\u6f64\u3002<\/p>\n

\u5728\u5177\u6709\u4e0d\u540cTROP2\/PD-L1\u8868\u9054\u6c34\u5e73\u7684CDX\u6a21\u578b\u4e2d\uff0cIBI3014\u76f8\u8f03\u65bcbenchmark ADC\u5c55\u73fe\u51fa\u66f4\u512a\u7684\u7d30\u80de\u6bba\u50b7\u6bd2\u6027\uff0c\u4e14\u53ef\u8986\u84cb\u66f4\u5ee3\u6cdb\u7684\u816b\u7624\u985e\u578b\u3002\u5728\u5c0f\u9f20\u548c\u98df\u87f9\u7334\u9ad4\u5167\u5747\u4fdd\u6301\u826f\u597d\u7684\u7a69\u5b9a\u6027\uff0c\u98df\u87f9\u7334\u5b89\u5168\u6027\u7814\u7a76\u986f\u793a\u5176\u6700\u9ad8\u975e\u56b4\u91cd\u6bd2\u6027\u5291\u91cf\uff08HNSTD\uff09\u70ba50 mg\/kg\uff0c\u8010\u53d7\u6027\u826f\u597d\u3002<\/p>\n

IBI3014\u4e0d\u50c5\u986f\u8457\u63d0\u9ad8\u4e86\u6cbb\u7642\u6548\u679c\uff0c\u540c\u6642\u7dad\u6301\u4e86\u826f\u597d\u7684\u5b89\u5168\u6027\u7279\u5fb5\uff0c\u70ba\u5be6\u9ad4\u7624\u6cbb\u7642\u63d0\u4f9b\u4e86\u7a81\u7834\u6027\u7b56\u7565\u3002<\/p>\n

\u6703\u8b70\u985e\u5225\uff1a\u5be6\u9a57\u8207\u5206\u5b50\u6cbb\u7642\u5b78 – \u91dd\u5c0d\u816b\u7624\u5fae\u74b0\u5883\u7684\u6cbb\u7642\u7b56\u7565
\u6a19\u984c\uff1aTrop2\u00d7B7H4\u96d9\u6297ADC\u5728\u5a66\u79d1\u816b\u7624\u6cbb\u7642\u4e2d\u5c55\u73fe\u51fa\u66f4\u597d\u7684\u7642\u6548\u548c\u5b89\u5168\u6027
\u6458\u8981\u865f\uff1a345
\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831
\u6642\u9593\uff1a2025\u5e744\u670827\u65e5\uff08\u661f\u671f\u65e5\uff092:00 PM – 5:00 PM\uff08\u7576\u5730\u6642\u9593\uff09
\u5730\u9ede\uff1aPoster Section 16<\/p>\n

IBI3022 \u662f\u4e00\u6b3e\u9776\u5411Trop2\/B7H4\u7684\u96d9\u7279\u7570\u6027ADC\uff0c\u901a\u904e\u7d50\u5408\u55ae\u81c2Trop2\u6297\u9ad4\u548c\u4f4e\u6bd2\u6027NT3 linker payload\u4f86\u964d\u4f4e\u8207Trop2\u76f8\u95dc\u7684\u812b\u9776\u6bd2\u6027\u3002<\/p>\n

\u9ad4\u5916\u7814\u7a76\u8868\u660e\uff0cIBI3022\u5728\u904e\u8868\u9054Trop2\u548cB7H4\u7684HT29\u7d30\u80de\u4e2d\u8868\u73fe\u51fa\u512a\u65bcTrop2\u6216B7H4\u00a0 benchmark ADC\u7684\u7d30\u80de\u6bba\u50b7\u6bd2\u6027\u3002\u9ad4\u5167\u7814\u7a76\u4e2d\uff0cIBI3022\u5728\u4e0d\u540c\u8868\u9054\u6c34\u5e73\u7684Trop2\u548cB7H4\u816b\u7624\u6a21\u578b\u4e2d\u5c55\u793a\u4e86\u8f03\u55ae\u6297benchmark ADC\u66f4\u5f37\u7684\u816b\u7624\u6291\u5236\u6548\u679c\u3002<\/p>\n

IBI3022\u4f5c\u70ba\u4e00\u7a2e\u6709\u6f5b\u529b\u7684\u7528\u65bc\u6cbb\u7642\u5a66\u79d1\u816b\u7624\u7684\u96d9\u7279\u7570\u6027ADC\uff0c\u5177\u6709\u66f4\u597d\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u3002<\/p>\n

\u6703\u8b70\u985e\u5225\uff1a\u5be6\u9a57\u8207\u5206\u5b50\u6cbb\u7642\u5b78 – \u91dd\u5c0d\u816b\u7624\u5fae\u74b0\u5883\u7684\u6cbb\u7642\u7b56\u7565
\u6a19\u984c\uff1aIBI3026\uff0c\u4e00\u7a2e\u5168\u7403\u9996\u5275\uff08First-in-Class\uff09\u7684\u6297PD-1\/IL-12\u878d\u5408\u86cb\u767d\uff0c\u901a\u904e\u89e3\u9664\u514d\u75ab\u53cd\u61c9\u7684\u6291\u5236\u4e26\u5f37\u6548\u6fc0\u6d3b\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u7684T\u7d30\u80de\u548cNK\u7d30\u80de\uff0c\u5c55\u73fe\u51fa\u6210\u70ba\u65b0\u578b\u816b\u7624\u514d\u75ab\u7642\u6cd5\u7684\u6f5b\u529b
\u6458\u8981\u865f\uff1a3118
\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831
\u6642\u9593\uff1a2025\u5e744\u670828\u65e5\uff08\u661f\u671f\u4e00\uff092:00 PM – 5:00 PM\uff08\u7576\u5730\u6642\u9593\uff09
\u5730\u9ede\uff1aPoster Section 24<\/p>\n

IBI3026 \u662f\u4e00\u6b3e\u5168\u7403\u9996\u5275\u7684\u9776\u5411PD-1\u548cIL-12\u53d7\u9ad4\u7684\u96d9\u7279\u7570\u6027\u514d\u75ab\u6fc0\u52d5\u5291\uff0c\u901a\u904e\u964d\u4f4eIL-12\u6d3b\u6027\u4f86\u63d0\u9ad8\u5b89\u5168\u6027\uff0c\u540c\u6642\u901a\u904ePD-1\u967d\u6027T\u7d30\u80de\u5bcc\u96c6\u5be6\u73fe\u816b\u7624\u9776\u5411\u6fc0\u6d3b\u3002<\/p>\n

\u5728\u7d93\u9810\u8655\u7406\u7684\u4eba\u5916\u5468\u8840\u55ae\u500b\u6838\u7d30\u80de\uff08PBMCs\uff09\u4e2d\uff0cIBI3026\u5c55\u73fe\u51fa\u986f\u8457\u7684\u514d\u75ab\u6fc0\u6d3b\u6548\u61c9\uff08STAT4\/IFN-\u03b3\u4fe1\u865f\u901a\u8def\u6fc0\u6d3b\uff09\uff0c\u4e26\u5728\u591a\u7a2e\u816b\u7624\u6a21\u578b\uff08EMT6\u3001CT26\u3001A375\u3001BxPC-3\uff09\u4e2d\u5be6\u73fe\u5b8c\u5168\u816b\u7624\u6291\u5236\u3002\u98df\u87f9\u7334\u5b89\u5168\u6027\u7814\u7a76\u986f\u793a\u5176\u6700\u9ad8\u975e\u56b4\u91cd\u6bd2\u6027\u5291\u91cf\uff08HNSTD\uff09\u70ba150 mg\/kg\uff0c\u6cbb\u7642\u6307\u6578\u905463\u3002<\/p>\n

IBI3026\u5c07PD-1\u963b\u65b7\u8207\u5c40\u90e8IL-12\u6fc0\u6d3b\u76f8\u7d50\u5408\uff0c\u70ba\u7576\u524d\u514d\u75ab\u7642\u6cd5\u8010\u85e5\u6027\u816b\u7624\u63d0\u4f9b\u4e86\u5275\u65b0\u6cbb\u7642\u7b56\u7565\u3002<\/p>\n

\u6703\u8b70\u985e\u5225\uff1a\u514d\u75ab\u5b78 – T\u7d30\u80de\u929c\u63a5\u5668
\u6a19\u984c\uff1a\u4e00\u7a2e2+1\u5f62\u5f0f\u7684MUC16\u9776\u5411T\u7d30\u80de\u929c\u63a5\u5668\u8a98\u5c0eMUC16\u4f9d\u8cf4\u6027T\u7d30\u80de\u6d3b\u6027\u4e26\u8868\u73fe\u51fa\u5353\u8d8a\u7684\u6297\u816b\u7624\u6d3b\u6027
\u6458\u8981\u865f\uff1a3510
\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831
\u6642\u9593\uff1a2025\u5e744\u670828\u65e5\uff08\u661f\u671f\u4e00\uff092:00 PM – 5:00 PM\uff08\u7576\u5730\u6642\u9593\uff09
\u5730\u9ede\uff1aPoster Section 38<\/p>\n

\u6b64\u6b21\u5831\u544a\u5206\u5b50\u662f\u4e00\u7a2e2+1\u5f62\u5f0f\u7684MUC16 \u9776\u5411T\u7d30\u80de\u929c\u63a5\u5668\uff08TCE\uff09\uff0c\u5177\u6709\u6539\u5584\u7684\u816b\u7624\u7d30\u80de\u7d50\u5408\u89aa\u548c\u529b\uff0c\u589e\u5f37\u7684\u816b\u7624\u7d30\u80de\u6bba\u50b7\u6d3b\u6027\u4ee5\u53caMUC16\u4f9d\u8cf4\u6027T\u7d30\u80de\u7d50\u5408\u548c\u6fc0\u6d3b\u3002<\/p>\n

\u81e8\u5e8a\u524d\u7814\u7a76\u986f\u793a\uff0c\u76f8\u8f03\u65bcbenchmark TCE\uff0c\u8a72\u5206\u5b50\u5728\u6c92\u6709 MUC16 \u7684\u60c5\u6cc1\u4e0b\u986f\u793a\u51fa\u6709\u9650\u7684 T \u7d30\u80de\u7d50\u5408\u548c\u6fc0\u6d3b\uff0c\u5f9e\u800c\u6700\u5927\u9650\u5ea6\u5730\u6e1b\u5c11\u4e86\u812b\u9776\u6bd2\u6027\u3002\u5728xenograft\u6a21\u578b\u4e2d\u4e5f\u986f\u793a\u51fa\u826f\u597d\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\u7279\u5fb5\uff0c\u4e14\u812b\u9776\u6bd2\u6027\u986f\u8457\u964d\u4f4e\u3002<\/p>\n

\u8a72\u5206\u5b50\u5728\u6cbb\u7642MUC16\u967d\u6027\u816b\u7624\uff08\u5c24\u5176\u662f\u5316\u7642\u8010\u85e5\u6027\u5375\u5de2\u764c\uff09\u65b9\u9762\u5c55\u73fe\u51fa\u91cd\u5927\u6f5b\u529b\uff0c\u8207\u73fe\u6709\u6cbb\u7642\u65b9\u6848\u806f\u7528\u6642\u53ef\u7522\u751f\u5354\u540c\u6548\u679c\uff0c\u53ef\u80fd\u4f7f\u4e0d\u540cMUC16\u8868\u9054\u6c34\u5e73\u7684\u60a3\u8005\u7fa4\u9ad4\u7372\u76ca\u3002<\/p>\n

\u6703\u8b70\u985e\u5225\uff1a\u5be6\u9a57\u8207\u5206\u5b50\u6cbb\u7642\u5b78 – \u65b0\u8208\u764c\u75c7\u85e5\u7269\u9776\u9ede
\u6a19\u984c\uff1aIBI3019\uff0c\u4e00\u7a2e\u5168\u7403\u9996\u5275\uff08First-in-Class\uff09\u7684EGFR\/CDH17\/CD16A\u4e09\u7279\u7570\u6027\u6297\u9ad4\uff0c\u5728\u81e8\u5e8a\u524d\u7814\u7a76\u4e2d\u5c0d\u7d50\u76f4\u8178\u764c\uff08CRC\uff09\u5c55\u73fe\u51fa\u5f37\u6548\u7642\u6548\u548c\u512a\u7570\u7684\u5b89\u5168\u6027\u7279\u5fb5
\u6458\u8981\u865f\uff1a4249
\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831
\u6642\u9593\uff1a2025\u5e744\u670829\u65e5\uff08\u661f\u671f\u4e8c\uff099:00 AM – 12:00 PM\uff08\u7576\u5730\u6642\u9593\uff09
\u5730\u9ede\uff1aPoster Section 17<\/p>\n

IBI3019 \u662f\u4e00\u6b3e\u9776\u5411EGFR\u3001CDH17\u548cCD16A\u7684\u65b0\u578b\u4e09\u7279\u7570\u6027\u6297\u9ad4\uff0c\u7528\u65bc\u7d50\u76f4\u8178\u764c\u6cbb\u7642\u3002\u8a72\u5206\u5b50\u901a\u904e\u9776\u5411\u816b\u7624\u9ad8\u8868\u9054\u7684CDH17\u589e\u5f37\u816b\u7624\u7279\u7570\u6027EGFR\u6291\u88fd\u4f5c\u7528\uff0c\u540c\u6642\u6e1b\u5c11\u5728EGFR\u7642\u6cd5\u4e2d\u5e38\u898b\u7684\u76ae\u819a\u6bd2\u6027\u3002<\/p>\n

\u6b64\u5916\uff0cIBI3019\u6574\u5408\u4e86\u9ad8\u89aa\u548c\u529b\u7684CDH16A\u7d0d\u7c73\u6297\u9ad4\uff0c\u6bd4\u4f4e\u5dd6\u85fb\u7cd6Fc\u6709 \u66f4\u512a\u8d8a\u7684\u6297\u9ad4\u4f9d\u8cf4\u6027\u7d30\u80de\u6bd2\u6027\uff08ADCC\uff09\u6548\u61c9\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0cIBI3019\u4e0d\u4f46\u5728\u9ad4\u5167\u5916\u5be6\u9a57\u90fd\u986f\u793a\u51fa\u6bd4Cetuximab (EGFR\u55ae\u6297) \u548cAmivantamab\uff08EGFR\/c-Met\u96d9\u6297\uff09\u66f4\u5f37\u7684\u6297\u816b\u7624\u6548\u679c, \u800c\u4e14\u5728\u98df\u87f9\u7334\u88e1\u975e\u5e38\u8010\u53d7\uff0c\u5176\u6700\u9ad8\u975e\u56b4\u91cd\u6bd2\u6027\u5291\u91cf\uff08HNSTD\uff09\u70ba150 mg\/kg\u3002\u9019\u4e9b\u4ee4\u4eba\u9f13\u821e\u7684\u81e8\u5e8a\u524d\u767c\u73fe\u503c\u5f97\u9032\u4e00\u6b65\u5c55\u958b\u81e8\u5e8a\u7814\u7a76\u3002<\/p>\n

\u6703\u8b70\u985e\u5225\uff1a\u514d\u75ab\u5b78 – \u816b\u7624\u5fae\u74b0\u5883\u8abf\u63a7\uff1a\u6dcb\u5df4\u7d30\u80de\u6d78\u6f64\u7684\u8abf\u7bc0
\u6a19\u984c\uff1a\u4e00\u7a2ePD1-IFN\u03b1\u878d\u5408\u86cb\u767d\uff0c\u7531\u6e1b\u6bd2IFN\u03b1\u8207\u81e8\u5e8a\u9a57\u8b49\u7684PD1\u55ae\u6297\u878d\u5408\u800c\u6210\uff0c\u53ef\u8a98\u5c0ePD1\u4f9d\u8cf4\u6027IFN\u03b1\u4fe1\u865f\u901a\u8def\u6fc0\u6d3b\u4e26\u5c55\u73fe\u51fa\u5353\u8d8a\u7684\u6297\u816b\u7624\u6d3b\u6027
\u6458\u8981\u865f\uff1a4881
\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831
\u6642\u9593\uff1a2025\u5e744\u670829\u65e5\uff08\u661f\u671f\u4e8c\uff099:00 AM – 12:00 PM\uff08\u7576\u5730\u6642\u9593\uff09
\u5730\u9ede\uff1aPoster Section 40<\/p>\n

\u6b64\u6b21\u5831\u544a\u5206\u5b50\u662f\u4e00\u7a2e\u65b0\u578bPD1\/IFN\u03b1\u878d\u5408\u86cb\u767d\uff0c\u8a72\u5206\u5b50\u5c07\u6e1b\u6d3b\u6027\u5e72\u64fe\u7d20\u03b1\uff08IFN\u03b1\uff09\u8207\u4fe1\u8fea\u5229\u55ae\u6297\uff08Sintilimab\uff09\u7d50\u5408\uff0c\u65e2\u80fd\u6709\u6548\u963b\u65b7PD1\/PDL1\u4fe1\u865f\u901a\u8def\uff0c\u53c8\u80fd\u5f15\u767c\u9ad8\u5ea6PD1\u4f9d\u8cf4\u6027\u7684IFN\u03b1\u4fe1\u865f\u50b3\u5c0e\uff0c\u5f9e\u800c\u9078\u64c7\u6027\u5730\u6fc0\u6d3bPD1\u9ad8\u8868\u9054\u7d30\u80de\u3002<\/p>\n

\u81e8\u5e8a\u524d\u7814\u7a76\u8868\u660e\uff0c\u5728\u591a\u7a2e\u5c0f\u9f20\u540c\u6e90\u816b\u7624\u6a21\u578b\u4e2d\uff0c\u8a72\u5206\u5b50\u7684\u6297\u816b\u7624\u6d3b\u6027\u986f\u8457\u512a\u65bc\u55ae\u7368\u4f7f\u7528PD1\u55ae\u6297\uff0c\u4e14\u672a\u6aa2\u6e2c\u5230\u660e\u986f\u6bd2\u6027\uff0c\u4e26\u5c55\u73fe\u51fa\u826f\u597d\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\u7279\u5fb5\u3002<\/p>\n

\u9019\u7a2e\u96d9\u529f\u80fd\u5206\u5b50\u901a\u904e\u6574\u5408\u5169\u7a2e\u5df2\u9a57\u8b49\u7684\u6297\u764c\u6a5f\u5236\uff0c\u514b\u670d\u4e86\u7576\u524d\u514d\u75ab\u6aa2\u67e5\u9ede\u6291\u5236\u5291\uff08ICB\uff09\u7642\u6cd5\u7684\u5c40\u9650\u6027\uff0c\u6709\u671b\u70ba\u80f0\u817a\u764c\u3001\u5375\u5de2\u764c\u53ca\u5fae\u885b\u661f\u7a69\u5b9a\uff08MSS\uff09\u7d50\u76f4\u8178\u764c\u7b49ICB\u96e3\u6cbb\u6027\u816b\u7624\u60a3\u8005\u63d0\u4f9b\u65b0\u7684\u6cbb\u7642\u9078\u64c7\u3002<\/p>\n

\u95dc\u65bc\u4fe1\u9054\u751f\u7269 <\/p>\n

\u300c\u59cb\u65bc\u4fe1\uff0c\u9054\u65bc\u884c\u300d\uff0c\u958b\u767c\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8cea\u91cf\u751f\u7269\u85e5\uff0c\u662f\u4fe1\u9054\u751f\u7269\u7684\u4f7f\u547d\u548c\u76ee\u6a19\u3002\u4fe1\u9054\u751f\u7269\u6210\u7acb\u65bc2011\u5e74\uff0c\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u7684\u5275\u65b0\u85e5\u7269\uff0c\u8b93\u6211\u5011\u7684\u5de5\u4f5c\u60e0\u53ca\u66f4\u591a\u7684\u751f\u547d\u3002\u516c\u53f8\u5df2\u670915\u500b\u7522\u54c1\u7372\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c\u5b83\u5011\u5206\u5225\u662f\u4fe1\u8fea\u5229\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u4f2f\u8212\u00ae\uff09\uff0c\u8c9d\u4f10\u73e0\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u6538\u540c\u00ae\uff09\uff0c\u963f\u9054\u6728\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u8607\u7acb\u4fe1\u00ae\uff09\uff0c\u5229\u59a5\u6614\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u4f2f\u83ef\u00ae\uff09\uff0c\u4f69\u7c73\u66ff\u5c3c\u7247\uff08\u9054\u4f2f\u5766\u00ae\uff09\uff0c\u5967\u96f7\u5df4\u66ff\u5c3c\u7247\uff08\u8010\u7acb\u514b\u00ae\uff09\uff0c \u96f7\u83ab\u897f\u5c24\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u5e0c\u5189\u64c7\u00ae\uff09\uff0c\u585e\u666e\u66ff\u5c3c\u81a0\u56ca\uff08\u777f\u59a5\u00ae\uff09\uff0c\u4f0a\u57fa\u5967\u4f96\u8cfd\u6ce8\u5c04\u6db2\uff08\u798f\u53ef\u8607\u00ae\uff09\uff0c\u6258\u840a\u897f\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u4fe1\u5fc5\u6a02\u00ae\uff09\uff0c\u6c1f\u6fa4\u96f7\u585e\u7247\uff08\u9054\u4f2f\u7279\u00ae\uff09\uff0c\u5339\u59a5\u5e03\u66ff\u5c3c\u7247(\u6377\u5e15\u529b\u00ae)\uff0c\u5df1\u4e8c\u9178\u4ed6\u96f7\u66ff\u5c3c\u81a0\u56ca\uff08\u9054\u4f2f\u6a02\u00ae\uff09\uff0c\u5229\u5384\u66ff\u5c3c\u7247\uff08\u5967\u58f9\u65b0\u00ae\uff09\u548c\u66ff\u59a5\u5c24\u55ae\u6297N01\u6ce8\u5c04\u6db2\uff08\u4fe1\u5fc5\u654f\u00ae\uff09\u3002\u76ee\u524d\uff0c\u540c\u6642\u9084\u67093\u500b\u54c1\u7a2e\u5728NMPA\u5be9\u8a55\u4e2d\uff0c4\u500b\u65b0\u85e5\u5206\u5b50\u9032\u5165III\u671f\u6216\u95dc\u9375\u6027\u81e8\u5e8a\u7814\u7a76\uff0c\u53e6\u5916\u9084\u670915\u500b\u65b0\u85e5\u54c1\u7a2e\u5df2\u9032\u5165\u81e8\u5e8a\u7814\u7a76\u3002<\/p>\n

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