{"id":25389,"date":"2025-03-30T11:10:00","date_gmt":"2025-03-30T03:10:00","guid":{"rendered":"https:\/\/www.franchise.com.hk\/%e9%a8%b0%e7%9b%9b%e5%8d%9a%e8%97%a5%e5%9c%a82025%e5%b9%b4%e4%ba%9e%e5%a4%aa%e8%82%9d%e7%97%85%e5%ad%b8%e6%9c%83%e5%b9%b4%e6%9c%83%ef%bc%88apasl%ef%bc%89%e4%b8%8a%e5%85%ac%e4%bd%88%e5%85%b6%e6%ad%a3\/25389"},"modified":"2025-03-30T11:10:00","modified_gmt":"2025-03-30T03:10:00","slug":"%e9%a8%b0%e7%9b%9b%e5%8d%9a%e8%97%a5%e5%9c%a82025%e5%b9%b4%e4%ba%9e%e5%a4%aa%e8%82%9d%e7%97%85%e5%ad%b8%e6%9c%83%e5%b9%b4%e6%9c%83%ef%bc%88apasl%ef%bc%89%e4%b8%8a%e5%85%ac%e4%bd%88%e5%85%b6%e6%ad%a3","status":"publish","type":"post","link":"https:\/\/www.franchise.com.hk\/zh-hans\/%e9%a8%b0%e7%9b%9b%e5%8d%9a%e8%97%a5%e5%9c%a82025%e5%b9%b4%e4%ba%9e%e5%a4%aa%e8%82%9d%e7%97%85%e5%ad%b8%e6%9c%83%e5%b9%b4%e6%9c%83%ef%bc%88apasl%ef%bc%89%e4%b8%8a%e5%85%ac%e4%bd%88%e5%85%b6%e6%ad%a3\/25389","title":{"rendered":"\u9a30\u76db\u535a\u85e5\u57282025\u5e74\u4e9e\u592a\u809d\u75c5\u5b78\u6703\u5e74\u6703\uff08APASL\uff09\u4e0a\u516c\u4f48\u5176\u6b63\u5728\u9032\u884c\u76842\u671fENSURE\u7814\u7a76\u7684\u65b0\u6578\u64da\uff0c\u8868\u660eBRII-179\u6709\u671b\u901a\u904e\u76ee\u6a19\u60a3\u8005\u8b58\u5225\u63d0\u9ad8HBsAg\u6e05\u9664\u7387"},"content":{"rendered":"

ENSURE\u7814\u7a76\u968a\u52174\u7684\u521d\u6b65\u6578\u64da\u652f\u6301\u4e00\u9805\u65b0\u7a4e\u7684\u5bcc\u96c6\u7b56\u7565\uff0c\u5229\u7528BRII-179\u8b58\u5225\u514d\u75ab\u61c9\u7b54\u60a3\u8005\uff0c\u4f7f\u5176\u6709\u671b\u5728\u6cbb\u7642\u7d50\u675f\u6642\uff08EOT\uff09\u5be6\u73fe\u66f4\u9ad8\u7684HBsAg\u6e05\u9664\u7387 ENSURE\u7814\u7a76\u968a\u52171-3\u768448\u5468EOT\u6578\u64da\u6e05\u695a\u8868\u660e\uff0celebsiran\u806f\u5408PEG-IFN\u03b1\u6cbb\u7642\u53ef\u5be6\u73fe\u984d\u5916\u7372\u76ca\uff0c\u9054\u5230\u66f4\u9ad8\u7684HBsAg\u6e05\u9664\u7387 <\/p>\n

\u4e2d\u570b\u5317\u4eac\u548c\u7f8e\u570b\u5317\u5361\u7f85\u4f86\u7d0d\u5dde\u9054\u52d2\u59c6<\/span>2025\u5e743\u670830\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u9a30\u76db\u535a\u85e5\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\uff08\u300c\u9a30\u76db\u535a\u85e5\u300d\u6216\u300c\u516c\u53f8\u300d\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a2137.HK\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u91dd\u5c0d\u60a3\u8005\u9700\u6c42\u672a\u88ab\u6eff\u8db3\u7684\u75be\u75c5\u958b\u767c\u6cbb\u7642\u65b9\u6848\uff0c\u4ee5\u6539\u5584\u60a3\u8005\u5065\u5eb7\u72c0\u6cc1\u548c\u6cbb\u7642\u9078\u64c7\u7684\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u4f48\uff0c\u5728\u4e2d\u570b\u5317\u4eac\u8209\u884c\u7684\u7b2c34\u5c46\u4e9e\u592a\u809d\u75c5\u5b78\u6703\u5e74\u6703\uff08APASL 2025\uff09\u4e0a\uff0c\u516c\u53f8\u4ee5\u6700\u65b0\u7a81\u7834\u53e3\u982d\u5831\u544a\u7684\u5f62\u5f0f\u516c\u4f48\u4e86\u5176\u6b63\u5728\u9032\u884c\u7684ENSURE 2\u671f\u7814\u7a76\u7684\u6700\u65b0\u6578\u64da\u3002<\/p>\n

\n<\/div>\n

ENSURE\uff08NCT05970289\uff09\u662f\u4e00\u9805\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u60272\u671f\u7814\u7a76\u3002\u968a\u52171-3\u65e8\u5728\u8a55\u4f30elebsiran\uff08\u4e00\u7a2e\u7814\u7a76\u6027\u5c0f\u5e72\u64fe\u6838\u7cd6\u6838\u9178\uff08siRNA\uff09\uff09\u5728\u8207\u805a\u4e59\u4e8c\u9187\u5e72\u64fe\u7d20\u03b1\uff08PEG-IFN\u03b1\uff09\u806f\u5408\u6cbb\u7642\u6162\u6027\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u8005\uff08\u57fa\u7dda\u4e59\u809d\u8868\u9762\u6297\u539f\uff08HBsAg\uff09\u6c34\u5e73\u70ba100-3,000 IU\/mL\uff09\u4e2d\u7684\u4f5c\u7528\u3002\u5728\u5148\u524d\u7684\u4e9e\u592a\u5730\u5340\u7814\u7a76BRII-179-835-001\uff08NCT04749368\uff09\u4e2d\u63a5\u53d7\u904e9\u5291BRII-179\uff08\u4e00\u7a2e\u57fa\u65bc\u91cd\u7d44\u86cb\u767d\u7684\u6cbb\u7642\u6027\u75ab\u82d7\uff09\u806f\u5408elebsiran\uff08BRII-835\uff09\u7d66\u85e5\u7684\u53c3\u8207\u8005\u88ab\u7d0d\u5165\u8a72\u7814\u7a76\u7684\u968a\u52174\uff0c\u4e26\u63a5\u53d7elebsiran\u548cPEG-IFN\u03b1\u806f\u5408\u6cbb\u7642\u3002\u672c\u7814\u7a76\u968a\u52174\u7684\u8a2d\u8a08\u57fa\u65bc\u65e2\u5f80\u7814\u7a76\u7684\u898b\u89e3\uff0c\u5373\u5f88\u5927\u4e00\u90e8\u5206\u6162\u6027HBV\u60a3\u8005\u5728\u63a5\u53d7\u6cbb\u7642\u6027\u75ab\u82d7\u7684\u591a\u6b21\u6cbb\u7642\u5f8c\u672a\u80fd\u7522\u751f\u8db3\u5920\u7684\u514d\u75ab\u61c9\u7b54\uff0c\u56e0\u6b64\u4e0d\u592a\u53ef\u80fd\u7372\u5f97\u514d\u75ab\u652f\u6301\u4ee5\u5be6\u73fe\u6301\u4e45\u7684\u529f\u80fd\u6027\u6cbb\u7652\u3002<\/p>\n

\u968a\u52174\u7684\u6700\u65b0\u6578\u64da\u986f\u793a\uff0c\u904e\u5f80\u7522\u751fBRII-179\u8a98\u5c0e\u7684\u4e59\u809d\u8868\u9762\u6297\u9ad4\uff08\u6297-HBs\uff09\u61c9\u7b54\u7684\u53c3\u8207\u8005\uff0c\u5176HBsAg\u8840\u6e05\u6e05\u9664\u7387\u986f\u8457\u9ad8\u65bc\u672a\u7522\u751f\u61c9\u7b54\u7684\u53c3\u8207\u8005\u3002\u7b2c24\u5468\u6642\uff0c\u8d85\u904e\u534a\u6578\u7684BRII-179\u61c9\u7b54\u8005\uff0855.6% [10\/18]\uff09\u5be6\u73fe\u4e86HBsAg\u8840\u6e05\u6e05\u9664\uff0c\u800c\u7121\u61c9\u7b54\u8005\u53ea\u670910.0%\uff081\/10\uff09\u5be6\u73fe\u4e86HBsAg\u8840\u6e05\u6e05\u9664\u3002\u672c\u6b21\u516c\u4f48\u7684\u6578\u64da\u8868\u660e\uff0cBRII-179\u6709\u6f5b\u529b\u6210\u70ba\u4e00\u7a2e\u9810\u6e2c\u5de5\u5177\uff0c\u7528\u65bc\u7be9\u9078\u51fa\u66f4\u53ef\u80fd\u5c0d\u6cbb\u7652\u65b9\u6cd5\u7522\u751f\u61c9\u7b54\u7684\u60a3\u8005\u3002<\/p>\n

\u6b64\u6b21\u516c\u4f48\u7684ENSURE\u7814\u7a76\u4e2d\u968a\u52171-3\u984d\u5916\u6578\u64da\u986f\u793a\uff0c\u8207\u63a5\u53d7PEG-IFN\u03b1\u55ae\u85e5\u6cbb\u7642\u7684\u53c3\u8207\u8005\u76f8\u6bd4\uff0c\u63a5\u53d7elebsiran\u806f\u5408PEG-IFN\u03b1\u6cbb\u7642\u7684\u53c3\u8207\u8005\u5728\u6cbb\u7642\u7d50\u675f (EOT) \u6642\u6709\u66f4\u9ad8\u7684HBsAg\u6e05\u9664\u7387\u548c\u8840\u6e05\u8f49\u63db\u7387\u3002<\/p>\n

\u9ec3\u9e97\u8679\u6559\u6388\uff08\u9999\u6e2f\u4e2d\u6587\u5927\u5b78\u91ab\u5b78\u6578\u64da\u5206\u6790\u4e2d\u5fc3\uff08MDAC\uff09\u53ca\u9999\u6e2f\u4e2d\u6587\u5927\u5b78\u5167\u79d1\u53ca\u85e5\u7269\u6cbb\u7642\u5b78\u7cfb\u8178\u80c3\u53ca\u809d\u75c5\u79d1\u5c08\u79d1\u6559\u6388\uff09\u8868\u793a\uff1a\u300cENSURE\u7814\u7a76\u968a\u52174\u7684\u7a4d\u6975\u6578\u64da\u70baHBV\u529f\u80fd\u6027\u6cbb\u7652\u6253\u958b\u4e86\u65b0\u7684\u5927\u9580\u3002\u65e2\u5f80\u7814\u7a76\u8868\u660e\uff0cBRII-179\u53ef\u80fd\u70ba\u8b58\u5225\u80fd\u5920\u7522\u751f\u5fc5\u8981\u7684HBsAg\u6297\u9ad4\u61c9\u7b54\u7684\u6162\u6027\u4e59\u578b\u809d\u708e \uff08CHB\uff09\u60a3\u8005\u63d0\u4f9b\u65b0\u8def\u5f91\u3002\u6211\u76f8\u4fe1\uff0c\u9019\u6b21\u7684\u65b0\u6578\u64da\u70baBRII-179\u5728\u7be9\u9078\u6cbb\u7642\u7372\u76ca\u4eba\u7fa4\u65b9\u9762\u7684\u50f9\u503c\u63d0\u4f9b\u4e86\u6709\u529b\u7684\u8b49\u64da\uff0c\u9032\u4e00\u6b65\u78ba\u7acb\u4e86BRII-179\u5728\u672a\u4f86\u806f\u5408\u7642\u6cd5\u683c\u5c40\u4e2d\u7684\u5730\u4f4d\u3002\u300d<\/p>\n

\u9a30\u76db\u535a\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98David Margolis\u535a\u58eb\u8868\u793a\uff1a\u300cENSURE\u7814\u7a76\u968a\u52174\u7684\u6578\u64da\u7e7c\u7e8c\u652f\u6301\u6211\u5011\u5728\u76ee\u6a19\u4eba\u7fa4\u4e2d\u958b\u767c\u6162\u6027HBV\u529f\u80fd\u6027\u6cbb\u7652\u7684\u5bcc\u96c6\u7b56\u7565\uff0c\u9019\u4ee4\u6211\u5011\u5099\u53d7\u9f13\u821e\u3002\u7814\u7a76\u7d50\u679c\u9032\u4e00\u6b65\u51f8\u986f\u4e86BRII-179\u5728\u8b58\u5225\u66f4\u53ef\u80fd\u5c0d\u529f\u80fd\u6027\u6cbb\u7652\u7642\u6cd5\u7522\u751f\u61c9\u7b54\u7684\u60a3\u8005\u65b9\u9762\u7684\u6f5b\u529b\uff0c\u901a\u904e\u60a3\u8005\u5bcc\u96c6\u7b56\u7565\u80fd\u63d0\u9ad8\u76ee\u6a19\u4eba\u7fa4\u7684\u529f\u80fd\u6027\u6cbb\u7652\u7387\uff0c\u540c\u6642\u6709\u52a9\u65bc\u964d\u4f4e\u6cbb\u7652\u6982\u7387\u8f03\u4f4e\u4eba\u7fa4\u7684\u6cbb\u7642\u6210\u672c\u8ca0\u64d4\u3002\u6211\u5011\u81f4\u529b\u65bc\u901a\u904e\u6b63\u5728\u958b\u5c55\u7684\u81e8\u5e8a\u7814\u7a76\u4ee5\u53ca\u8207\u6230\u7565\u5408\u4f5c\u5925\u4f34\u7684\u5408\u4f5c\uff0c\u5c07BRII-179\u8207\u591a\u7a2e\u7642\u6cd5\u7d50\u5408\u4f7f\u7528\uff0c\u4ee5\u671f\u70ba\u5168\u74032.54\u5104\u6162\u6027HBV\u611f\u67d3\u60a3\u8005\u5be6\u73fe\u66f4\u9ad8\u7684\u529f\u80fd\u6027\u6cbb\u7652\u7387\u3002\u300d<\/p>\n

\u6458\u8981\u7de8\u865f\uff1aOP0335<\/p>\n

\u5831\u544a\u6a19\u984c\uff1a\u5c0d\u65e2\u5f80BRII-179\u6cbb\u7642\u7522\u751f\u61c9\u7b54\u7684\u6162\u6027\u4e59\u578b\u809d\u708e\u75c5\u6bd2\u611f\u67d3\u8005\u5728\u63a5\u53d7elebsiran \u548c PEG-IFN\u03b1 \u6cbb\u7642\u5f8c\u53ef\u7372\u5f97\u66f4\u5feb\u66f4\u9ad8\u7684HBsAg\u6e05\u9664\uff1a\u4f86\u81eaENSURE\u7814\u7a76\u7684\u521d\u6b65\u6578\u64da\u00a0<\/p>\n

\u4e3b\u8b1b\u4eba\uff1a\u9ec3\u9e97\u8679\u6559\u6388\uff0cMBChB\uff08CUHK\uff09\uff0cMD\uff08CUHK\uff09\uff0cFRCP\uff08Lond, Edin\uff09\uff0cFHKCP\uff0cFHKAM\uff08Medicine\uff09\uff0c\u9999\u6e2f\u4e2d\u6587\u5927\u5b78\u91ab\u5b78\u6578\u64da\u5206\u6790\u4e2d\u5fc3\uff08MDAC\uff09\u53ca\u9999\u6e2f\u4e2d\u6587\u5927\u5b78\u5167\u79d1\u53ca\u85e5\u7269\u6cbb\u7642\u5b78\u7cfb\u8178\u80c3\u53ca\u809d\u75c5\u79d1\u5c08\u79d1\u6559\u6388\uff0c\u4e2d\u570b\u9999\u6e2f\u7279\u5225\u884c\u653f\u5340<\/p>\n

\u5728\u968a\u52174\u4e2d\u5165\u7d44\u768431\u4f8b\u53c3\u8207\u8005\u4e2d\uff0c\u670928\u4f8b\u57fa\u7ddaHBsAg \u2265 100 IU\/mL\u7684\u53c3\u8207\u8005\u88ab\u7d0d\u5165\u5206\u6790\u3002\u5176\u4e2d\uff0c18\u4f8b\u901a\u904e\u5148\u524dBRII-179\u6cbb\u7642\u8a98\u5c0e\u7684\u6297-HBs\u5cf0\u503c\u226510 IU\/L\u7684\u53d7\u8a66\u8005\u88ab\u5b9a\u7fa9\u70baBRII-179\u61c9\u7b54\u8005\uff0c10\u4f8b\u6297-HBs\u5cf0\u503c<10 IU\/L\u7684\u53d7\u8a66\u8005\u88ab\u5b9a\u7fa9\u70ba\u7121\u61c9\u7b54\u8005\u3002 \u5728elebsiran + PEG-IFN\u03b1\u6cbb\u7642\u7b2c24\u5468\u6642\uff0c\u968a\u52174\u53c3\u8207\u8005\u4e2d\u670939.3%\uff0811\/28\uff09\u5be6\u73fe\u4e86HBsAg\u8840\u6e05\u6e05\u9664\u3002 \u7b2c24\u5468\u6642\uff0cBRII-179\u61c9\u7b54\u8005\u7684HBsAg\u8840\u6e05\u6e05\u9664\u7387\u70ba55.6%\uff0810\/18\uff09\uff0c\u660e\u986f\u9ad8\u65bc\u7121\u61c9\u7b54\u8005\u768410%\uff081\/10\uff09\u3002 \u8207\u6b64\u524d\u5831\u544a\u7684\u63a5\u53d7elebsiran + PEG-IFN\u03b1\u6cbb\u7642\u4f46\u672a\u7d93BRII-179\u6cbb\u7642\u7684\u53c3\u8207\u8005\u76f8\u6bd4\uff0c\u65e2\u5f80\u63a5\u53d7BRII-179\u6cbb\u7642\u7684\u61c9\u7b54\u8005\u4f3c\u4e4e\u53ef\u4ee5\u5be6\u73fe\u66f4\u5feb\u7684HBsAg\u8840\u6e05\u6e05\u9664\u3002 \u75c5\u6bd2\u5b78\u6291\u5236\u7684\u6162\u6027HBV\u611f\u67d3\u53c3\u8207\u8005\u4e2d\uff0celebsiran\u806f\u5408PEG-IFN\u03b1\u6cbb\u7642\u7e3d\u9ad4\u5b89\u5168\u4e14\u8010\u53d7\u6027\u826f\u597d\u3002 Elebsiran + PEG-IFN\u03b1\u6cbb\u7642\u6703\u6301\u7e8c48\u5468\u3002 <\/p>\n

\u6458\u8981\u7de8\u865f\uff1aLB0009<\/p>\n

\u5831\u544a\u6a19\u984c\uff1a\u8207\u55ae\u7528 PEG-IFN\u03b1 \u76f8\u6bd4\uff0c\u63a5\u53d7 elebsiran \u548cPEG-IFN\u03b1\u6cbb\u7642\u7684\u6162\u6027 HBV \u611f\u67d3\u8005\u5728\u6cbb\u7642\u7d50\u675f (EOT) \u6642 HBsAg \u6e05\u9664\u7387\u548c\u8840\u6e05\u8f49\u63db\u7387\u66f4\u9ad8\uff1a \u6b63\u5728\u9032\u884c\u7684ENSURE\u7814\u7a76\u7b2c48\u5468\u7d50\u679c<\/p>\n

\u4e3b\u8b1b\u4eba\uff1a\u8cc8\u7e7c\u6771\u6559\u6388\uff0cM.D.\uff0cPh.D.\uff0c\u9996\u90fd\u91ab\u79d1\u5927\u5b78\u9644\u5c6c\u5317\u4eac\u53cb\u8abc\u91ab\u9662\u809d\u75c5\u7814\u7a76\u4e2d\u5fc3\u4e3b\u4efb\uff0c\u4e2d\u570b\u5317\u4eac<\/p>\n

EOT\u6642\uff0c\u5728\u57fa\u7ddaHBsAg\u6c34\u5e73\u70ba100-3,000 IU\/mL\u7684\u53c3\u8207\u8005\u4e2d\uff0celebsiran 200 mg + PEG-IFN\u03b1\u968a\u5217\u548celebsiran 100 mg + PEG-IFN\u03b1\u968a\u5217\u7684HBsAg\u8840\u6e05\u6e05\u9664\u7387\u5206\u5225\u70ba26.3%\uff085\/19\uff09\u548c33.3%\uff086\/18\uff09\uff0c\u660e\u986f\u9ad8\u65bcPEG-IFN\u03b1\u55ae\u85e5\u6cbb\u7642\u968a\u5217\uff085.6%\uff09\u3002 \u8207PEG-IFN\u03b1\u968a\u5217\uff08-1.02 [0.30] log10 IU\/mL\uff09\u76f8\u6bd4\uff0celebsiran + PEG-IFN\u03b1\u968a\u5217\u5728EOT\u6642\u7684HBsAg\u4e0b\u964d\u5e45\u5ea6\u66f4\u5927\uff08\u5e73\u5747\u503c[SE]\uff1aelebsiran 200 mg\u6216100 mg\u5206\u5225\u70ba-2.47 [0.28]\u6216-3.01 [0.28] log10 IU\/mL\uff09\u3002 Elebsiran\u806f\u5408PEG-IFN\u03b1\u6cbb\u7642\uff08\u5291\u91cf\u5206\u5225\u70ba200 mg\u548c100 mg\uff09\uff0c\u5728HBsAg\u4e0b\u964d\u5e45\u5ea6\u548c\u8840\u6e05\u6e05\u9664\u7387\u65b9\u9762\u5747\u8868\u73fe\u51fa\u76f8\u4f3c\u7684\u6548\u679c\u3002\u5728\u75c5\u6bd2\u5b78\u6291\u5236\u7684\u6162\u6027HBV\u611f\u67d3\u53c3\u8207\u8005\u4e2d\uff0celebsiran\u806f\u5408PEG-IFN\u03b1\u7642\u6cd5\u7e3d\u9ad4\u5b89\u5168\u4e14\u8010\u53d7\u6027\u826f\u597d\u3002 \u6cbb\u7642\u5f8c\u96a8\u8a2a\u4ecd\u5728\u9032\u884c\u4e2d\uff0c\u4e26\u5c07\u6301\u7e8c\u96a8\u8a2a\u81f3\u6cbb\u7642\u7d42\u6b62\u5f8c\u7b2c24\u5468\u3002 <\/p>\n

\u4f5c\u70ba\u9a30\u76db\u535a\u85e5\u958b\u767cHBV\u529f\u80fd\u6027\u6cbb\u7652\u7684\u7368\u7279\u7642\u6cd5\u7684\u4e00\u90e8\u5206\uff0c\u516c\u53f8\u53ca\u5176\u5408\u4f5c\u5925\u4f34\u6b63\u5728\u7a4d\u6975\u63a8\u9032\u6211\u5011\u5dee\u7570\u5316\u7522\u54c1\u7d44\u5408\u7684\u591a\u9805\u806f\u5408\u7814\u7a76\uff0c\u5305\u62ec BRII-179\uff08\u4e00\u7a2e\u91cd\u7d44\u86cb\u767dHBV\u514d\u75ab\u6cbb\u7642\u5019\u9078\u85e5\u7269\uff0c\u7531\u9a30\u76db\u535a\u85e5\u958b\u5c55 elebsiran \u548c BRII-179 \u806f\u5408\u7642\u6cd5\u7684\u7814\u7a76\uff09 \u3001elebsiran\uff08\u7531\u9a30\u76db\u535a\u85e5\u958b\u5c55 elebsiran \u548c PEG-IFN\u03b1 \u806f\u5408\u7814\u7a76\uff09\u4ee5\u53catobevibart\uff08\u4e00\u7a2e\u9776\u5411HBV\u7684\u7814\u7a76\u6027\u5ee3\u6cdb\u4e2d\u548c\u55ae\u514b\u9686\u6297\u9ad4\uff0cVir Biotechnology\u6b63\u5c31tobevibart\u548celebsiran\u806f\u5408\u7642\u6cd5\u958b\u5c55\u591a\u9805 2 \u671f\u548c 3 \u671f\u7814\u7a76 \uff09\u3002\u57282025\u5e74\u63a5\u4e0b\u4f86\u7684\u5e7e\u500b\u6708\uff0c\u6211\u5011\u5c07\u5728\u5404\u5927\u79d1\u5b78\u6703\u8b70\u4e0a\u6301\u7e8c\u5206\u4eab\u95dc\u9375\u6578\u64da\u3002<\/p>\n

\u95dc\u65bc\u4e59\u578b\u809d\u708e <\/p>\n

\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u662f\u4e16\u754c\u4e0a\u6700\u91cd\u5927\u7684\u611f\u67d3\u6027\u75be\u75c5\u5a01\u8105\u4e4b\u4e00\uff0c\u5168\u7403\u611f\u67d3\u4eba\u6578\u8d85\u904e2.54\u5104\u3002[1]\u6162\u6027HBV\u611f\u67d3\u662f\u809d\u81df\u75be\u75c5\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u6bcf\u5e74\u7d04\u670982\u842c\u4eba\u6b7b\u65bc\u6162\u6027HBV\u611f\u67d3\u7684\u4f75\u767c\u75c7\u3002[1]\u4e2d\u570b\u6162\u6027HBV\u611f\u67d3\u4eba\u6578\u90548,700\u842c\uff0c\u975e\u5e38\u503c\u5f97\u95dc\u6ce8\u3002[2]<\/p>\n

\u95dc\u65bcBRII-179<\/p>\n

BRII-179\u662f\u4e00\u7a2e\u57fa\u65bc\u91cd\u7d44\u86cb\u767d\u8cea\u7684\u65b0\u578bHBV\u514d\u75ab\u6cbb\u7642\u5019\u9078\u85e5\u7269\uff0c\u53ef\u8868\u9054HBV\u7684Pre-S1\u3001Pre-S2\u548cS\u8868\u9762\u6297\u539f\uff0c\u65e8\u5728\u8a98\u5c0e\u589e\u5f37\u548c\u5ee3\u6cdb\u7684B\u7d30\u80de\u548cT\u7d30\u80de\u514d\u75ab\u61c9\u7b54\u30022023\u5e7411\u6708\uff0c\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u6388\u4e88BRII-179\u7a81\u7834\u6027\u6cbb\u7642\u8a8d\u5b9a\u3002<\/p>\n

\u95dc\u65bcElebsiran\uff08BRII-835\uff0cVIR-2218\uff09 <\/p>\n

Elebsiran\u662f\u4e00\u7a2e\u7d93\u76ae\u4e0b\u6ce8\u5c04\u7d66\u85e5\u7684\u9776\u5411HBV\u7684siRNA\u7814\u7a76\u6027\u85e5\u7269\uff0c\u65e8\u5728\u964d\u89e3\u4e59\u578b\u809d\u708e\u75c5\u6bd2RNA\u8f49\u9304\u672c\u53ca\u9650\u5236\u4e59\u578b\u809d\u708e\u8868\u9762\u6297\u539f\u7684\u7522\u751f\uff0c\u5176\u5177\u6709\u91dd\u5c0dHBV\u53caHDV\u7684\u76f4\u63a5\u6297\u75c5\u6bd2\u6d3b\u6027\u3002\u5176\u662f\u9996\u500b\u9032\u5165\u81e8\u5e8a\u7684\u63a1\u7528\u589e\u5f37\u7a69\u5b9a\u5316\u5b78\u589e\u5f37\u6280\u8853\u7684siRNA\uff0c\u4ee5\u589e\u5f37\u7a69\u5b9a\u6027\u4e26\u6700\u5927\u7a0b\u5ea6\u5730\u6e1b\u5c11\u812b\u9776\u6d3b\u6027\uff0c\u5f9e\u800c\u6709\u53ef\u80fd\u63d0\u9ad8\u6cbb\u7642\u6307\u6578\u3002\u9a30\u76db\u535a\u85e5\u65bc2020\u5e74\u5f9eVir Biotechnology, Inc.\u7372\u5f97\u4e86\u5728\u5927\u4e2d\u83ef\u5730\u5340\u958b\u767c\u548c\u5546\u696d\u5316elebsiran\u7684\u7368\u5bb6\u6b0a\u76ca\u3002<\/p>\n

\u95dc\u65bc\u9a30\u76db\u535a\u85e5<\/p>\n

\u9a30\u76db\u535a\u85e5\uff08\u80a1\u7968\u4ee3\u78bc\uff1a2137.HK\uff09\u662f\u4e00\u5bb6\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u91dd\u5c0d\u5b58\u5728\u5de8\u5927\u672a\u88ab\u6eff\u8db3\u7684\u60a3\u8005\u9700\u6c42\u3001\u6cbb\u7642\u624b\u6bb5\u6709\u9650\uff0c\u4ee5\u53ca\u7d66\u60a3\u8005\u5e36\u4f86\u56b4\u91cd\u793e\u6703\u6b67\u8996\u7684\u91cd\u5927\u516c\u5171\u885b\u751f\u6311\u6230\u958b\u767c\u5275\u65b0\u7642\u6cd5\u3002\u516c\u53f8\u5c08\u6ce8\u65bc\u611f\u67d3\u6027\u75be\u75c5\uff0c\u6b63\u5728\u63a8\u9032\u4e00\u689d\u6db5\u84cb\u591a\u7a2e\u7368\u7279\u5019\u9078\u85e5\u7269\u7684\u7522\u54c1\u7ba1\u7dda\uff0c\u91cd\u9ede\u5305\u62ec\u91dd\u5c0d\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u7684\u9818\u5148\u9805\u76ee\u3002\u5728\u5bcc\u6709\u9060\u898b\u5353\u8b58\u548c\u7d93\u9a57\u8c50\u5bcc\u7684\u9818\u5c0e\u5718\u968a\u5e36\u9818\u4e0b\uff0c\u516c\u53f8\u5728\u4f4d\u65bc\u7f85\u5229-\u9054\u52d2\u59c6\u3001\u820a\u91d1\u5c71\u7063\u5340\u3001\u5317\u4eac\u548c\u4e0a\u6d77\u7684\u4e3b\u8981\u751f\u7269\u6280\u8853\u4e2d\u5fc3\u958b\u5c55\u696d\u52d9\u3002\u6b32\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554fwww.briibio.com<\/a> \u3002<\/p>\n

\n

[1]\u00a0World Health Organization. (April 2024). Global hepatitis report 2024: action for access in low- and middle-income countries. World Health Organization. Retrieved from https:\/\/www.who.int\/publications\/i\/item\/9789240091672<\/span><\/p>\n

[2] World Health Organization. Hepatitis. World Health Organization. Retrieved from https:\/\/www.who.int\/china\/health-topics\/hepatitis#:~:text=There%20are%2087%20million%20people,living%20with%20chronic%20hepatitis%20C<\/a>.<\/span><\/p>\n<\/div>\n

\u00a0<\/p>","protected":false},"excerpt":{"rendered":"

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