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\u967d\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027NSCLC\u60a3\u8005\uff0c\u4ee5\u53casac-TMT\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u5c0d\u6bd4\u5316\u7642\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u4e00\u7dda\u6cbb\u7642PD-L1\u9670\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0NSCLC\u60a3\u8005\u7684\u5169\u98053\u671f\u8a3b\u518a\u7814\u7a76\u6b63\u5728\u9032\u884c\u4e2d\u3002<\/p>\n<p>\u535a\u5ea6\u66f2\u59a5\u73e0\u55ae\u6297\uff08HER2 ADC\uff0c\u4ea6\u7a31A166\uff09(\u8212\u6cf0\u83b1\u00ae)<\/p>\n<p>2025\u5e741\u6708\uff0c\u535a\u5ea6\u66f2\u59a5\u73e0\u55ae\u6297\u7684NDA\u5df2\u7372\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u53d7\u7406\uff0c\u7528\u65bc\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u904e\u4e00\u7a2e\u6297HER2\u6cbb\u7642\u7684HER2+\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027BC\u6210\u4eba\u60a3\u8005\u7684\u6cbb\u7642\u3002\u65bc\u9810\u8a2d\u7684\u671f\u4e2d\u5206\u6790\u4e2d\uff0c\u535a\u5ea6\u66f2\u59a5\u73e0\u55ae\u6297\u55ae\u85e5\u5728\u4e3b\u8981\u7814\u7a76\u7d42\u9ede\u76f2\u614b\u7368\u7acb\u4e2d\u5fc3\uff08BICR\uff09\u8a55\u4f30\u7684PFS\u65b9\u9762\u76f8\u8f03\u65bcT-DM1\u986f\u793a\u51fa\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u548c\u81e8\u5e8a\u610f\u7fa9\u7684\u6539\u5584\u3002<\/p>\n<p>\u57fa\u65bc\u4e3b\u8981\u5206\u6790\u7684\u7d50\u679c\uff0c\u535a\u5ea6\u66f2\u59a5\u73e0\u55ae\u6297\u5df2\u9054\u5230\u5176\u91dd\u5c0d3L+\u665a\u671fHER2+ BC\u7684\u95dc\u93752\u671f\u8a66\u9a57\u7684\u4e3b\u8981\u7d42\u9ede\uff0c\u800c\u516c\u53f8\u5df2\u7528\u6b64\u5411\u570b\u5bb6\u85e5\u76e3\u5c40\u905e\u4ea4NDA\u3002\u516c\u53f8\u5df2\u555f\u52d5\u535a\u5ea6\u66f2\u59a5\u73e0\u55ae\u6297\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u8f09\u8377\u70ba\u62d3\u64b2\u7570\u69cb\u9176\u6291\u5236\u5291\u6297\u9ad4\u85e5\u7269\u5076\u806f\u7269\uff08ADC\uff09\u7684HER2+\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027BC\u7684\u958b\u653e\u3001\u591a\u4e2d\u5fc32\u671f\u81e8\u5e8a\u7814\u7a76\u3002<\/p>\n<p>\u5176\u4ed6ADC\u53ca\u65b0\u578b\u5076\u806f\u85e5\u7269<\/p>\n<p>SKB315 (CLDN18.2 ADC) \u65b9\u9762\uff0cSKB315\u914d\u7f6e\u4e86\u81ea\u4e3b\u958b\u767c\u7684\u4eba\u6e90\u5316CLDN18.2 \u55ae\u6297\u53ca\u7368\u7279\u7684\u6709\u6548\u8f09\u8377\uff0d\u9023\u63a5\u5b50\u8a2d\u8a08\u3002SKB315\u7684\u65e9\u671f\u81e8\u5e8a\u6578\u64da\u986f\u793a\uff0c\u5728\u4e2d\u9ad8CLDN18.2\u8868\u9054\u7684\u80c3\u764c\u4e2d\u5177\u6709\u826f\u597d\u7684\u7642\u6548\u548c\u53ef\u63a5\u53d7\u7684\u5b89\u5168\u6027\u7279\u5fb5\u3002\u516c\u53f8\u6b63\u5728\u9032\u884cSKB315\u76841b\u671f\u81e8\u5e8a\u8a66\u9a57\u3002<\/p>\n<p>SKB410\/MK-3120 (Nectin-4 ADC) \u65b9\u9762\uff0cSKB410\u662f\u4e00\u6b3e\u9776\u5411\u665a\u671f\u5be6\u9ad4\u7624\u7684\u65b0\u578bNectin-4 ADC\uff0c\u4e26\u63a1\u7528\u5dee\u7570\u5316\u7684\u8f09\u8377\u9023\u63a5\u7b56\u7565\uff0c\u986f\u793a\u51fa\u4ee4\u4eba\u9f13\u821e\u76841\u671f\u81e8\u5e8a\u6578\u64da\u3002\u4f5c\u7232\u7533\u8fa6\u65b9\uff0c\u9ed8\u6c99\u6771\u5df2\u5553\u52d5SKB410\u7684\u5168\u74031\/2\u671f\u81e8\u5e8a\u8a66\u9a57\u3002<\/p>\n<p>SKB571\/MK-2750\u65b9\u9762\uff0cSKB571\u662f\u4e00\u6b3e\u6b63\u5728\u8207\u9ed8\u6c99\u6771\u5408\u4f5c\u958b\u767c\u7684\u65b0\u578b\u96d9\u6297\u00a0ADC\uff0c\u4e3b\u8981\u9776\u5411\u5404\u7a2e\u5be6\u9ad4\u7624\uff0c\u5982LC\u548cCRC\u7b49\u30021\u671f\u81e8\u5e8a\u8a66\u9a57\u6b63\u5728\u4e2d\u570b\u9032\u884c\u4e2d\u3002<\/p>\n<p>SKB518\u3001SKB535\/MK-6204\u53caSKB445\u65b9\u9762\uff0cSKB518\u3001SKB535\u53caSKB445\u662f\u5177\u6709\u6f5b\u5728FIC\u9776\u9ede\u7684\u65b0\u578bADC\u85e5\u7269\uff0c\u5404\u9805\u76841\u671f\u81e8\u5e8a\u8a66\u9a57\u5747\u5728\u4e2d\u570b\u9032\u884c\u4e2d\u3002\u516c\u53f8\u5df2\u8207\u9ed8\u6c99\u6771\u8a02\u7acb\u958b\u767cSKB535\u7684\u8a31\u53ef\u53ca\u5408\u4f5c\u5354\u8b70\u3002\u570b\u5bb6\u85e5\u76e3\u5c40\u5b98\u65b9\u7db2\u7ad9\u5ba3\u4f48\uff0c\u00a0SKB535\u70ba\u570b\u5bb6\u85e5\u76e3\u5c40\u6279\u51c6\u7684\u9996\u500b\u512a\u5316\u5275\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\u5be9\u8a55\u5be9\u6279\u8a66\u9ede\u9805\u76ee\uff0c\u5be9\u8a55\u5be9\u6279\u7528\u664221\u65e5\u3002<\/p>\n<p>SKB500 \u53caSKB501\u65b9\u9762\uff0cSKB500\u53caSKB501\u662f\u5177\u6709\u7d93\u9a57\u8b49\u9776\u9ede\u4f46\u63a1\u7528\u5dee\u7570\u5316\u6709\u6548\u8f09\u8377\u00a0\u2014\u00a0\u9023\u63a5\u7b56\u7565\u7684\u65b0\u578bADC\u85e5\u7269\u3002\u65bc2024\u5e7411\u6708\u53ca12\u6708\uff0c\u516c\u53f8\u5206\u5225\u7372\u5f97\u570b\u5bb6\u85e5\u76e3\u5c40\u6279\u51c6SKB501\u53caSKB500\u7528\u65bc\u6cbb\u7642\u665a\u671f\u5be6\u9ad4\u7624\u7684IND\u7533\u8acb\u7684\u81e8\u5e8a\u8a66\u9a57\u901a\u77e5\u3002<\/p>\n<p>SKB107\u65b9\u9762\uff0cSKB107\u662f\u4e00\u6b3e\u7531\u516c\u53f8\u8207\u897f\u5357\u91ab\u5927\u9644\u5c6c\u91ab\u9662\u5171\u540c\u958b\u767c\u7684\u9776\u5411\u816b\u7624\u9aa8\u8f49\u79fb\u7684RDC\u85e5\u7269\u3002\u65bc2025\u5e741\u6708\uff0c\u570b\u5bb6\u85e5\u76e3\u5c40\u5df2\u53d7\u7406SKB107\u7684IND\u7533\u8acb\u3002<\/p>\n<p>\u4e09\u6b3e\u5275\u65b0\u85e5\u7372\u6279\u4e0a\u5e02\u00a0\u00a0\u7522\u54c1\u7ba1\u7dda\u9081\u5411\u5546\u696d\u5316\u6210\u529f<\/p>\n<p>\u76ee\u524d\uff0c\u516c\u53f8\u5df2\u7372\u5f97\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\uff08\u4f73\u6cf0\u83b1\u00ae\uff09\u53ca\u5854\u6208\u5229\u55ae\u6297\uff08\u79d1\u6cf0\u83b1\u00ae\uff09\u53ca\u897f\u59a5\u6614\u55ae\u6297N01\uff08\u8fbe\u6cf0\u83b1\u00ae\uff09\u7684\u4e0a\u5e02\u8a31\u53ef\uff0c\u4e26\u5df2\u958b\u59cb\u5176\u5546\u696d\u5316\u3002\u516c\u53f8\u9810\u671f\u65bc2025\u5e74\u5728\u4e2d\u570b\u5e02\u5834\u63a8\u51fa\u535a\u5ea6\u66f2\u59a5\u73e0\u55ae\u6297\uff08\u8212\u6cf0\u83b1\u00ae\uff09\u4e26\u70baA400\u905e\u4ea4NDA\u3002<\/p>\n<p>\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\uff08\u4f73\u6cf0\u83b1\u00ae\uff09\u662f\u4e2d\u570b\u9996\u500b\u570b\u7522\u539f\u5275TROP2\u9776\u9edeADC\u5275\u65b0\u85e5\uff0c\u4e5f\u662f\u4e2d\u570b\u9996\u500b\u7372\u5f97\u5b8c\u5168\u6279\u51c6\u4e0a\u5e02\u7684ADC\u7522\u54c1\uff0c\u70ba\u4e2d\u570b\u4e09\u9670\u6027\u4e73\u817a\u764c\u665a\u671f\u60a3\u8005\u63d0\u4f9b\u4e86\u5168\u65b0\u3001\u66f4\u512a\u7684\u6cbb\u7642\u8def\u5f91\u3002<\/p>\n<p>\u5854\u6208\u5229\u55ae\u6297\uff08PD-L1\u55ae\u6297\uff0c\u524d\u7a31A167\uff09(\u79d1\u6cf0\u83b1\u00ae)\u662f\u5168\u7403\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7528\u65bc\u9f3b\u54bd\u764c\u4e00\u7dda\u6cbb\u7642\u7684PD-L1\u55ae\u6297\u30022024\u5e7412\u6708\uff0c\u5854\u6208\u5229\u55ae\u6297\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e2\u7dda\u53ca\u4ee5\u4e0a\u5316\u7642\u5931\u6557\u7684\u5fa9\u767c\u6216\u8f49\u79fb\u6027\u9f3b\u54bd\u764c\u60a3\u8005\u7372NMPA\u6279\u51c6\u65bc\u4e2d\u570b\u4e0a\u5e02\u30022025\u5e741\u6708\uff0c\u5854\u6208\u5229\u55ae\u6297\u806f\u5408\u9806\u9251\u548c\u5409\u897f\u4ed6\u6ff1\u7528\u65bc\u4e00\u7dda\u6cbb\u7642\u5fa9\u767c\u6216\u8f49\u79fb\u6027\u9f3b\u54bd\u764c\u60a3\u8005\u7372NMPA\u6279\u51c6\u65bc\u4e2d\u570b\u4e0a\u5e02\u3002<\/p>\n<p>\u897f\u59a5\u6614\u55ae\u6297N01\uff08EGFR \u55ae\u6297\uff0c\u524d\u7a31A140\uff09(\u8fbe\u6cf0\u83b1\u00ae)\u30022025\u5e742\u6708\uff0c\u897f\u59a5\u6614\u55ae\u6297N01\u6ce8\u5c04\u6db2\u7528\u65bc\u8207FOLFOX\u6216FOLFIRI\u65b9\u6848\u806f\u5408\u7528\u65bc\u4e00\u7dda\u6cbb\u7642RAS\u57fa\u56e0\u91ce\u751f\u578b\u7684\u8f49\u79fb\u6027\u7d50\u76f4\u8178\u764c\u7372NMPA\u6279\u51c6\u65bc\u4e2d\u570b\u4e0a\u5e02\u3002\u6839\u64da\u4e00\u9805\u5927\u6a23\u672c\u570b\u51673\u671f\u81e8\u5e8a\u7814\u7a76\u7684\u7d50\u679c\uff0c\u8a72\u7814\u7a76\u5c0d\u897f\u59a5\u6614\u55ae\u6297N01\u6ce8\u5c04\u6db2\u8207\u897f\u59a5\u6614\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u7231\u5fc5\u59a5\u00ae\uff09\u9032\u884c\u4e86\u6b63\u9762\u6bd4\u8f03\uff0c\u897f\u59a5\u6614\u55ae\u6297N01\u806f\u5408\u5316\u7642\u5728ORR\u65b9\u9762\u5177\u6709\u81e8\u5e8a\u7b49\u6548\u6027\uff08\u897f\u59a5\u6614\u55ae\u6297N01\u5c0d\u6bd4\u897f\u59a5\u6614\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u7231\u5fc5\u59a5\u00ae\uff09\uff1a71.0%\u5c0d\u6bd477.5%\uff1bORR\u6bd4\u7387\u70ba0.93 [95% CI: 0.87, 0.99]\uff09\uff0c\u800c\u4e14\u897f\u59a5\u6614\u55ae\u6297N01\u5728DoR\u548cPFS\u65b9\u9762\u8207\u897f\u59a5\u6614\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u7231\u5fc5\u59a5\u00ae\uff09\u76f8\u6bd4\u4e26\u7121\u986f\u793a\u51fa\u4efb\u4f55\u81e8\u5e8a\u610f\u7fa9\u6216\u7d71\u8a08\u5b78\u986f\u8457\u5dee\u7570\uff08\u4e2d\u4f4dPFS\uff1a10.9\u500b\u6708\u5c0d\u6bd410.8\u500b\u6708\uff0cHR\uff1a1.03 [95% CI: 0.83, 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