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2024\u5e74\u7b2c\u56db\u5b63\u5ea6\u7e3d\u6536\u5165\u70ba1.091\u5104\u7f8e\u5143\uff0c\u540c\u6bd4\u589e\u957766%\u30022024\u5e74\u5168\u5e74\u7e3d\u6536\u5165\u70ba3.990\u5104\u7f8e\u5143\uff0c\u540c\u6bd4\u589e\u957750%\uff1b2025\u5e74\u5168\u5e74\u6536\u5165\u6307\u5f15\u70ba5.60\u5104\u7f8e\u5143\u81f35.90\u5104\u7f8e\u5143
\n\u885b\u5049\u8fe6\u00ae\u548c\u885b\u529b\u8fe6\u00ae 2024 \u5e74\u7b2c\u56db\u5b63\u5ea6\u92b7\u552e\u6536\u5165\u9054\u5230 3,000 \u842c\u7f8e\u5143\uff0c2024 \u5e74\u5168\u5e74\u92b7\u552e\u6536\u5165\u9054\u5230 9,360 \u842c\u7f8e\u5143
\n 2024 \u5e74\u7b2c\u56db\u5b63\u5ea6\u7d93\u71df\u8667\u640d\u70ba6,790 \u842c\u7f8e\u5143\uff0c\u540c\u6bd4\u4e0b\u964d 45% \uff0c2024 \u5e74\u5168\u5e74\u7d93\u71df\u8667\u640d\u70ba2.821\u5104\u7f8e\u5143\uff0c\u540c\u6bd4\u4e0b\u964d 23%
\n\u7528\u65bc\u5c0f\u7d30\u80de\u80ba\u764c\uff08SCLC\uff09\u7684\u5168\u7403 1 \u671f\u7814\u7a76\u7684\u65e9\u671f\u81e8\u5e8a\u6578\u64da\u986f\u793a\uff0cORR \u70ba 74%\uff0cZL-1310 (DLL3 ADC) \u5177\u6709\u6210\u70ba\u540c\u985e\u9996\u5275\u4e14\u540c\u985e\u6700\u4f73\u85e5\u7269\u7684\u6f5b\u529b\uff1b\u518d\u9f0e\u91ab\u85e5\u64c1\u6709ZL-1310\u7684\u5168\u7403\u6b0a\u5229\u4e26\u6709\u671b\u65bc2025\u5e74\u4e0a\u534a\u5e74\u7684\u91cd\u8981\u91ab\u5b78\u6703\u8b70\u4e0a\uff0c\u516c\u4f48\u7528\u65bcSCLC\u7684\u7814\u7a76\u6578\u64da\u66f4\u65b0\uff0c\u4e26\u57282025\u5e74\u4e0a\u534a\u5e74\u63a2\u7d22\u7528\u65bc\u5176\u4ed6\u795e\u7d93\u5167\u5206\u6ccc\u816b\u7624\u7684\u6f5b\u529b <\/p>\n

\u95dc\u9375\u5340\u57df\u7ba1\u7dda\u4e0d\u65b7\u63a8\u9032\uff0c\u5305\u62ecKarXT\u7528\u65bc\u6cbb\u7642\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\uff08NDA\uff09\u7372\u53d7\u7406\uff0c\u518d\u9f0e\u91ab\u85e5\u7684\u514d\u75ab\u7ba1\u7dda\u901a\u904e\u5305\u62ec\u7528\u65bcIgAN\u7684povetacicept \u5728\u5167\u7684\u5f8c\u671f\u7ba1\u7dda\u8cc7\u7522\u9032\u4e00\u6b65\u52a0\u5f37<\/p>\n

\u516c\u53f8\u5c07\u65bc\u4eca\u5929\uff082025\u5e742\u670827\u65e5\uff09\u7f8e\u570b\u6771\u90e8\u6642\u9593\u4e0a\u5348 8:00\uff08\u9999\u6e2f\u6642\u9593\u665a\u4e0a9:00\uff09\u8209\u884c\u96fb\u8a71\u6703\u8b70\u548c\u7db2\u7d61\u76f4\u64ad<\/p>\n

\u4e2d\u570b\u4e0a\u6d77\u548c\u7f8e\u570b\u99ac\u85a9\u8af8\u585e\u5dde\u528d\u6a4b<\/span>2025\u5e742\u670827\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u518d\u9f0e\u91ab\u85e5\u6709\u9650\u516c\u53f8\uff08\u7d0d\u65af\u9054\u514b\u80a1\u7968\u4ee3\u78bc\uff1aZLAB\uff1b\u9999\u6e2f\u806f\u4ea4\u6240\u80a1\u4efd\u4ee3\u865f\uff1a9688\uff09\u4eca\u65e5\u516c\u4f48\u4e862024\u5e74\u7b2c\u56db\u5b63\u5ea6\u548c\u5168\u5e74\u8ca1\u52d9\u696d\u7e3e\uff0c\u4ee5\u53ca\u8fd1\u671f\u7684\u7522\u54c1\u4eae\u9ede\u548c\u516c\u53f8\u9032\u5c55\u3002<\/p>\n

\u518d\u9f0e\u91ab\u85e5\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u9577\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u675c\u7469\u535a\u58eb\u8868\u793a\uff1a\u300c2024\u5e74\u5c0d\u518d\u9f0e\u91ab\u85e5\u800c\u8a00\u662f\u5177\u6709\u6c7a\u5b9a\u6027\u7684\u4e00\u5e74\uff0c\u9019\u4e00\u5e74\u6211\u5011\u5be6\u73fe\u4e86\u5f37\u52c1\u7684\u92b7\u552e\u589e\u9577\u3001\u7a69\u5065\u7684\u8ca1\u52d9\u4ee5\u53ca\u91cd\u5927\u7684\u7ba1\u7dda\u9032\u5c55\u3002\u5c55\u671b\u672a\u4f86\uff0c\u4f34\u96a8\u8457\u827e\u52a0\u83ab\u5fb7\u6301\u7e8c\u7684\u589e\u9577\u52e2\u982d\u3001\u4e09\u6b3e\u65b0\u7522\u54c1\u7684\u4e0a\u5e02\u3001ZL-1310\u7684\u63a8\u9032\u4ee5\u53ca\u95dc\u9375\u7ba1\u7dda\u8cc7\u7522\u7684\u6f5b\u5728\u8a3b\u518a\u91cc\u7a0b\u7891\uff0c2025\u5e74\u5c07\u6210\u70ba\u6211\u5011\u7684\u86fb\u8b8a\u4e4b\u5e74\u3002\u827e\u52a0\u83ab\u5fb7\u5728\u4e0a\u5e02\u9996\u500b\u5b8c\u6574\u5e74\u5ea6\u5c31\u51fa\u8272\u5730\u5be6\u73fe\u4e869,360\u842c\u7f8e\u5143\u7684\u7522\u54c1\u6536\u5165\u6de8\u984d\uff0c\u51f8\u986f\u4e86\u4e2d\u570b\u60a3\u8005\u5c0d\u5275\u65b0\u7642\u6cd5\u7684\u4e9f\u9700\u3002\u4eca\u5e741\u6708\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u53d7\u7406\u4e86KarXT\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\uff08NDA\uff09\uff0c\u8b93\u6211\u5011\u5411\u8457\u5c07\u9019\u4e00\u5275\u65b0\u85e5\u7269\u60e0\u53ca\u6709\u9700\u8981\u7684\u4e2d\u570b\u60a3\u8005\u53c8\u9081\u9032\u4e00\u6b65\u3002\u8207\u6b64\u540c\u6642\uff0c\u6211\u5011\u64c1\u6709\u5168\u7403\u6b0a\u5229\u7684\u7ba1\u7ddaZL-1310\u5c55\u73fe\u4e86\u51fa\u8272\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u6578\u64da\uff0c\u986f\u793a\u51fa\u5176\u6210\u70ba\u6cbb\u7642SCLC\u7684\u540c\u985e\u9996\u5275\u548c\u540c\u985e\u6700\u4f73DLL3\u6297\u9ad4\u85e5\u7269\u5076\u806f\u7269\uff08ADC\uff09\u7684\u6f5b\u529b\u3002\u4eca\u5929\u7684\u518d\u9f0e\u91ab\u85e5\u8f03\u4ee5\u5f80\u66f4\u70ba\u5f37\u5927\uff0c\u5177\u5099\u5c07\u85e5\u7269\u5e36\u7d66\u5168\u7403\u60a3\u8005\u4e26\u70ba\u6211\u5011\u7684\u80a1\u6771\u5275\u9020\u50f9\u503c\u6240\u9700\u7684\u5805\u5be6\u57fa\u790e\u3001\u5275\u65b0\u529b\u53ca\u57f7\u884c\u529b\u3002\u300d<\/p>\n

\u518d\u9f0e\u91ab\u85e5\u7e3d\u88c1\u517c\u9996\u5e2d\u904b\u71df\u5b98Josh Smiley\u8868\u793a\uff1a\u300c2024\u5e74\u7b2c\u56db\u5b63\u5ea6\u548c\u5168\u5e74\u7e3d\u6536\u5165\u5206\u5225\u589e\u9577\u4e8666%\u548c50%\uff0c\u9019\u4e3b\u8981\u662f\u7531\u65bc\u827e\u52a0\u83ab\u5fb7\u6301\u7e8c\u7684\u5f37\u52c1\u8868\u73fe\u4ee5\u53ca\u5247\u6a02\u00ae\u548c\u7d10\u518d\u6a02\u00ae\u92b7\u552e\u6536\u5165\u7684\u6301\u7e8c\u589e\u9577\u3002\u5c55\u671b\u672a\u4f86\uff0c\u6211\u5011\u9810\u8a08\u7e7c\u7e8c\u4fdd\u6301\u986f\u8457\u7684\u71df\u6536\u589e\u9577\uff0c\u5728\u827e\u52a0\u83ab\u5fb7\u7528\u65bc\u5168\u8eab\u578b\u91cd\u75c7\u808c\u7121\u529b\uff08gMG\uff09\u548c\u6162\u6027\u708e\u6027\u812b\u9ad3\u9798\u6027\u591a\u767c\u6027\u795e\u7d93\u6839\u795e\u7d93\u75c5\uff08CIDP\uff09\u4ee5\u53ca\u5305\u62ecKarXT\u7528\u65bc\u7cbe\u795e\u5206\u88c2\u75c7\u3001\u8c9d\u746a\u59a5\u73e0\u55ae\u6297\u7528\u65bc\u80c3\u764c\u7b49\u5728\u5167\u7684\u5373\u5c07\u4e0a\u5e02\u7684\u6f5b\u5728\u91cd\u78c5\u7522\u54c1\u63a8\u52d5\u4e0b\uff0c \u6211\u5011\u7684\u76ee\u6a19\u662f\u57282028\u5e74\u5be6\u73fe20\u5104\u7f8e\u5143\u7684\u71df\u6536\u3002\u5275\u65b0\u7684\u5168\u7403\u6b0a\u5229\u7ba1\u7dda\u4ecd\u820a\u662f\u6211\u5011\u95dc\u6ce8\u7684\u7126\u9ede\uff0c\u9810\u8a08\u4eca\u5e74\u5c07\u6709\u591a\u9805\u7814\u7a76\u6578\u64da\u767c\u4f48\uff0cZL-1310\u6709\u671b\u6700\u65e9\u57282027\u5e74\u5c31\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\u3002\u6b64\u5916\uff0c\u6211\u5011\u986f\u8457\u6539\u5584\u4e86\u8ca1\u52d9\u72c0\u6cc1\uff0c\u5927\u5e45\u6e1b\u5c11\u4e86\u7d93\u71df\u8667\u640d\uff0c\u671d\u84572025\u5e74\u7b2c\u56db\u5b63\u5ea6\u5be6\u73fe\u975e\u7f8e\u570b\u516c\u8a8d\u6703\u8a08\u6e96\u5247\u7d93\u71df\u5229\u6f64\u76c8\u5229[1]\u7684\u76ee\u6a19\u7e7c\u7e8c\u9081\u9032\u3002\u6191\u501f\u7a69\u5065\u7684\u73fe\u91d1\u5132\u5099[2]\uff0c\u6211\u5011\u6709\u8db3\u5920\u7684\u8cc7\u91d1\u5728\u7e7c\u7e8c\u6295\u8cc7\u9ad8\u5f71\u97ff\u529b\u7684\u696d\u52d9\u589e\u9577\u6a5f\u6703\u7684\u540c\u6642\u5be6\u73fe\u9019\u4e00\u91cc\u7a0b\u7891\u3002\u300d<\/p>\n

\n

[1]\u975e\u7f8e\u570b\u516c\u8a8d\u6703\u8a08\u6e96\u5247\u7d93\u71df\u5229\u6f64\u76c8\u5229\u6307\u8abf\u6574\u5f8c\u7684\u7d93\u71df\u6536\u5165\uff08\u975e\u7f8e\u570b\u516c\u8a8d\u6703\u8a08\u6e96\u5247\uff09\uff0c\u8a08\u7b97\u65b9\u6cd5\u70ba\u5c07\u7f8e\u570b\u516c\u8a8d\u6703\u8a08\u6e96\u5247\u7d93\u71df\u6536\u5165\uff08\u8667\u640d\uff09\u7d93\u904e\u6263\u9664\u975e\u73fe\u91d1\u652f\u51fa\uff08\u5305\u62ec\u6298\u820a\u3001\u6524\u92b7\u548c\u4ee5\u80a1\u4efd\u70ba\u57fa\u790e\u7684\u916c\u91d1\uff09\u7684\u8abf\u6574\u3002\u6709\u95dc\u6b64\u8abf\u6574\u5f8c\u7684\u76c8\u5229\u6307\u6a19\u7684\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u53c3\u95b1\u300c\u975e\u7f8e\u570b\u516c\u8a8d\u6703\u8a08\u6e96\u5247\u6307\u6a19\u300d\u90e8\u5206\u3002<\/span><\/p>\n

[2]\u73fe\u91d1\u5132\u5099\u5305\u62ec\u73fe\u91d1\u53ca\u73fe\u91d1\u7b49\u50f9\u7269\u3001\u6d41\u52d5\u53d7\u9650\u5236\u73fe\u91d1\u548c\u77ed\u671f\u6295\u8cc7\u3002<\/span><\/p>\n<\/div>\n

2024\u5e74\u7b2c\u56db\u5b63\u5ea6\u548c\u5168\u5e74\u8ca1\u52d9\u696d\u7e3e<\/p>\n

2024 \u5e74\u7b2c\u56db\u5b63\u5ea6\u7522\u54c1\u6536\u5165\u6de8\u984d\u70ba 1.085 \u5104\u7f8e\u5143\uff0c2023 \u5e74\u540c\u671f\u70ba 6,580 \u842c\u7f8e\u5143\uff0c\u6309\u5be6\u969b\u532f\u7387\u548c\u56fa\u5b9a\u532f\u7387(CER)\u8a08\u7b97\u5747\u589e\u9577 65%\uff1b2024 \u5e74\u5168\u5e74\u7522\u54c1\u6536\u5165\u6de8\u984d\u70ba 3.976 \u5104\u7f8e\u5143\uff0c 2023 \u5e74\u540c\u671f\u70ba 2.667 \u5104\u7f8e\u5143\uff0c\u540c\u6bd4\u589e\u9577 49%\uff0c\u6309 CER \u8a08\u7b97\u540c\u6bd4\u589e\u957750%\u3002\u7522\u54c1\u6536\u5165\u589e\u9577\u4e3b\u8981\u662f\u7531\u65bc\u885b\u5049\u8fe6\u92b7\u91cf\u7684\u589e\u9577\uff0c\u540c\u6642\u4e5f\u5f97\u76ca\u65bc\u5247\u6a02\u548c\u7d10\u518d\u6a02\u7684\u92b7\u91cf\u589e\u9577\u3002
\n\u885b\u5049\u8fe6\u548c\u885b\u529b\u8fe62024 \u5e74\u7b2c\u56db\u5b63\u5ea6\u7522\u54c1\u6536\u5165\u6de8\u984d\u70ba 3,000 \u842c\u7f8e\u5143\uff0c2023 \u5e74\u540c\u671f\u70ba 510 \u842c\u7f8e\u5143\uff1b2024 \u5e74\u5168\u5e74\u7684\u7522\u54c1\u6536\u5165\u6de8\u984d\u70ba 9,360 \u842c\u7f8e\u5143\uff0c 2023 \u5e74\u540c\u671f\u70ba1,000 \u842c\u7f8e\u5143\u3002\u9019\u4e00\u589e\u9577\u4e3b\u8981\u662f\u7531\u65bc\u885b\u5049\u8fe6\u81ea2023\u5e749\u6708\u4e0a\u5e02\u4ee5\u4f86\u92b7\u552e\u984d\u7684\u589e\u9577\u4ee5\u53ca2024\u5e741\u67081\u65e5\u8d77\u5176\u7528\u65bc\u6cbb\u7642gMG\u88ab\u7d0d\u5165\u4e2d\u570b\u570b\u5bb6\u91ab\u4fdd\u85e5\u54c1\u76ee\u9304\uff08NRDL\uff09\u3002 \u5247\u6a02 2024 \u5e74\u7b2c\u56db\u5b63\u5ea6\u7522\u54c1\u6536\u5165\u6de8\u984d\u70ba 4,840 \u842c\u7f8e\u5143\uff0c\u8f03\u53bb\u5e74\u540c\u671f\u76844,160 \u842c\u7f8e\u5143\u589e\u957716%\uff1b2024 \u5e74\u5168\u5e74\u7684\u7522\u54c1\u6536\u5165\u6de8\u984d\u70ba 1.871 \u5104\u7f8e\u5143\uff0c\u8f03\u53bb\u5e74\u540c\u671f\u76841.688\u5104\u7f8e\u5143\u589e\u957711%\u3002\u5247\u6a02\u7684\u92b7\u552e\u4fdd\u6301\u5f37\u52c1\uff0c\u7e7c\u7e8c\u4fdd\u6301\u4e2d\u570b\u5167\u5730\u5375\u5de2\u764c\u9818\u57dfPARP\u6291\u5236\u5291\u9662\u5167\u92b7\u552e\u9818\u8ecd\u8005\u5730\u4f4d\u3002 \u7d10\u518d\u6a02 2024 \u5e74\u7b2c\u56db\u5b63\u5ea6\u7522\u54c1\u6536\u5165\u6de8\u984d\u70ba 1,100 \u842c\u7f8e\u5143\uff0c\u8f03\u53bb\u5e74\u540c\u671f\u7684610\u842c\u7f8e\u5143\u589e\u957781%\uff1b2024 \u5e74\u5168\u5e74\u7684\u7522\u54c1\u6536\u5165\u6de8\u984d\u70ba 4,320 \u842c\u7f8e\u5143\uff0c\u8f03\u53bb\u5e74\u540c\u671f\u76842,170\u842c\u7f8e\u5143\u589e\u957799%\u3002\u9019\u4e00\u589e\u9577\u5f97\u76ca\u65bc\u7d10\u518d\u6a02\u7528\u65bc\u6cbb\u7642\u793e\u5340\u7372\u5f97\u6027\u7d30\u83cc\u6027\u80ba\u708e(CABP)\u548c\u6025\u6027\u7d30\u83cc\u6027\u76ae\u819a\u548c\u76ae\u819a\u7d50\u69cb\u611f\u67d3(ABSSSI)\u7684\u6210\u4eba\u60a3\u8005\u7684\u975c\u8108\u6ce8\u5c04\u5291\u578b\u65bc2023\u5e741\u6708\u88ab\u7d0d\u5165NRDL\uff0c\u53e3\u670d\u5291\u578b\u65bc2024 \u5e741\u6708\u88ab\u7d0d\u5165NRDL\u3002\u7d10\u518d\u6a02\u975c\u8108\u6ce8\u5c04\u5291\u578b\u6210\u529f\u7e8c\u7d04NRDL\uff0c\u4e26\u65bc2025 \u5e74 1 \u6708\u751f\u6548\u3002 <\/p>\n

2024 \u5e74\u7b2c\u56db\u5b63\u5ea6\u7814\u767c (R&D) \u958b\u652f\u70ba 5,230 \u842c\u7f8e\u5143\uff0c2023 \u5e74\u540c\u671f\u70ba 8,190 \u842c\u7f8e\u5143\u30022024 \u5e74\u5168\u5e74\u7814\u767c\u958b\u652f\u70ba 2.345 \u5104\u7f8e\u5143\uff0c2023 \u5e74\u540c\u671f\u70ba 2.659 \u5104\u7f8e\u5143\u3002\u7814\u767c\u958b\u652f\u7684\u964d\u4f4e\u4e3b\u8981\u662f\u57fa\u65bc\u73fe\u6709\u7814\u7a76\u9805\u76ee\u7684\u9032\u5c55\uff0c\u90e8\u5206\u88ab\u8a31\u53ef\u8cbb\u7528\u7684\u589e\u52a0\u6240\u62b5\u92b7\u3002 2024 \u5e74\u7b2c\u56db\u5b63\u5ea6\u7684\u92b7\u552e\u3001\u4e00\u822c\u53ca\u884c\u653f (SG&A) \u958b\u652f\u70ba 8,260 \u842c\u7f8e\u5143\uff0c\u8207 2023 \u5e74\u540c\u671f\u6301\u5e73\u30022024 \u5e74\u5168\u5e74\u7684SG&A\u958b\u652f\u70ba 2.987 \u5104\u7f8e\u5143\uff0c 2023 \u5e74\u540c\u671f\u70ba 2.816 \u5104\u7f8e\u5143\u3002\u4e3b\u8981\u7531\u65bc\u827e\u52a0\u83ab\u5fb7\u4e0a\u5e02\u548c\u7d10\u518d\u6a02\u92b7\u552e\u589e\u52a0\u800c\u5c0e\u81f4\u7684\u4e00\u822c\u92b7\u552e\u8cbb\u7528\u7684\u589e\u52a0\uff0c\u90e8\u5206\u88ab\u5176\u4ed6\u7522\u54c1\u92b7\u552e\u8cbb\u7528\u6e1b\u5c11\u548c\u4e00\u822c\u53ca\u884c\u653f\u958b\u652f\u964d\u4f4e\u6240\u62b5\u92b7\u3002 2024 \u5e74\u7b2c\u56db\u5b63\u5ea6\u548c 2024 \u5e74\u5168\u5e74\u7684\u7d93\u71df\u8667\u640d\u5206\u5225\u70ba 6,790 \u842c\u7f8e\u5143\u548c 2.821 \u5104\u7f8e\u5143\uff0c\u7d93\u8abf\u6574\u6263\u9664\u6298\u820a\u3001\u6524\u92b7\u548c\u4ee5\u80a1\u4efd\u70ba\u57fa\u790e\u7684\u916c\u91d1\u7b49\u975e\u73fe\u91d1\u652f\u51fa\u5f8c\u5206\u5225\u70ba4,760\u842c\u7f8e\u5143\u548c1.996\u5104\u7f8e\u5143\uff0c2023 \u5e74\u7b2c\u56db\u5b63\u5ea6\u548c 2023 \u5e74\u5168\u5e74\u7684\u7d93\u71df\u8667\u640d\u5206\u5225\u70ba1.240\u5104\u7f8e\u5143\u548c3.666\u5104\u7f8e\u5143\u3002\u672c\u65b0\u805e\u7a3f\u672b\u5c3e\u9644\u6709\u7d93\u71df\u8667\u640d\uff08\u7f8e\u570b\u516c\u8a8d\u6703\u8a08\u6e96\u5247\uff09\u548c\u8abf\u6574\u5f8c\u7684\u7d93\u71df\u8667\u640d\uff08\u975e\u7f8e\u570b\u516c\u8a8d\u6703\u8a08\u6e96\u5247\uff09\u7684\u5c0d\u6bd4\u3002 2024 \u5e74\u7b2c\u56db\u5b63\u5ea6\u8667\u640d\u6de8\u984d\u70ba 8,170 \u842c\u7f8e\u5143\uff0c\u6b78\u5c6c\u65bc\u666e\u901a\u80a1\u80a1\u6771\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u8667\u640d 0.08\u7f8e\u5143\uff08\u6bcf\u4efd\u7f8e\u570b\u5b58\u6258\u80a1\u4efd\uff08ADS\uff09\u8667\u640d\u70ba0.80 \u7f8e\u5143\uff09\uff0c2023 \u5e74\u540c\u671f\u8667\u640d\u6de8\u984d\u70ba 9,540 \u842c\u7f8e\u5143\uff0c\u6b78\u5c6c\u65bc\u666e\u901a\u80a1\u80a1\u6771\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u8667\u640d 0.10\u7f8e\u5143\uff08\u6bcf\u4efdADS\u8667\u640d\u70ba0.98 \u7f8e\u5143\uff09\u30022024 \u5e74\u5168\u5e74\u8667\u640d\u6de8\u984d\u70ba 2.571 \u5104\u7f8e\u5143\uff0c\u6b78\u5c6c\u65bc\u666e\u901a\u80a1\u80a1\u6771\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u8667\u640d 0.26\u7f8e\u5143\uff08\u6bcf\u4efdADS\u8667\u640d\u70ba2.60\u7f8e\u5143\uff09\uff0c2023 \u5e74\u5168\u5e74\u8667\u640d\u6de8\u984d\u70ba 3.346 \u5104\u7f8e\u5143\uff0c\u6b78\u5c6c\u65bc\u666e\u901a\u80a1\u80a1\u6771\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u8667\u640d 0.35\u7f8e\u5143\uff08\u6bcf\u4efdADS\u8667\u640d\u70ba3.46\u7f8e\u5143\uff09\u3002\u8667\u640d\u6de8\u984d\u6e1b\u5c11\u4e3b\u8981\u662f\u7531\u65bc\u7522\u54c1\u6536\u5165\u589e\u9577\u5feb\u65bc\u904b\u71df\u958b\u652f\uff0c\u4f46\u88ab\u5229\u606f\u6536\u76ca\u6e1b\u5c11\u548c\u532f\u514c\u640d\u5931\u589e\u52a0\u6240\u62b5\u92b7\u3002 \u622a\u81f3 2024 \u5e74 12 \u6708 31 \u65e5\uff0c\u73fe\u91d1\u53ca\u73fe\u91d1\u7b49\u50f9\u7269\u3001\u77ed\u671f\u6295\u8cc7\u548c\u6d41\u52d5\u53d7\u9650\u5236\u73fe\u91d1\u7e3d\u8a08\u70ba 8.797 \u5104\u7f8e\u5143\uff0c\u622a\u81f3 2023 \u5e74 12 \u6708 31 \u65e5\u70ba 8.065\u5104\u7f8e\u5143\u3002 <\/p>\n

2025\u5e74\u6230\u7565\u91cd\u9ede<\/p>\n

2025\u5e74\u518d\u9f0e\u91ab\u85e5\u5c07\u805a\u7126\u4ee5\u4e0b\u6230\u7565\u91cd\u9ede\uff0c\u4ee5\u63a8\u52d5\u4e2d\u570b\u53ca\u5176\u4ed6\u5730\u5340\u7684\u5275\u65b0\u548c\u589e\u9577\uff1a<\/p>\n

\u5546\u696d\u5316\u57f7\u884c\u548c\u4e0a\u5e02\u6e96\u5099<\/p>\n

\u901a\u904e\u65b0\u60a3\u8005\u7684\u589e\u52a0\u548c\u6cbb\u7642\u9031\u671f\u7684\u5ef6\u9577\u63a8\u52d5\u885b\u5049\u8fe6\u7528\u65bcgMG\u4ee5\u53ca\u885b\u529b\u8fe6\u7528\u65bcgMG \u548cCIDP\u7684\u92b7\u91cf\u589e\u9577 \u4fdd\u6301\u5247\u6a02\u5728\u4e2d\u570b\u5167\u5730\u5375\u5de2\u764c\u9818\u57dfPARP\u6291\u5236\u5291\u9662\u5167\u92b7\u552e\u9818\u8ecd\u8005\u5730\u4f4d \u70ba\u8c9d\u746a\u59a5\u73e0\u55ae\u6297\u7528\u65bc\u80c3\u764c\u548c KarXT\u7528\u65bc\u7cbe\u795e\u5206\u88c2\u75c7\u7b49\u6f5b\u5728\u91cd\u78c5\u7522\u54c1\u7684\u5546\u696d\u5316\u4e0a\u5e02\u505a\u597d\u6e96\u5099 <\/p>\n

\u81e8\u5e8a\u958b\u767c <\/p>\n

\u5feb\u901f\u63a8\u9032\u64c1\u6709\u5168\u7403\u6b0a\u5229\u7684 ZL-1310\uff08DLL3 ADC\uff09\u7528\u65bcSCLC\u7684\u5168\u7403 1 \u671f\u7814\u7a76\uff0c\u4e26\u63a2\u7d22\u5176\u7528\u65bc\u5176\u5b83\u795e\u7d93\u5167\u5206\u6ccc\u816b\u7624\u7684\u6f5b\u529b \u63a8\u9032\u5305\u62ecZL-6201\uff08LRRC15 ADC\uff09\u548c ZL-1503\uff08IL-13\/IL-31R\uff09\u5728\u5167\u7684\u5176\u5b83\u5168\u7403\u6b0a\u5229\u7ba1\u7dda\u81f3\u5168\u74031\u671f\u81e8\u5e8a\u958b\u767c\u968e\u6bb5 \u5728\u64c1\u6709\u5340\u57df\u6b0a\u5229\u7684\u514d\u75ab\u7ba1\u7dda\u4e2d\uff0c\u52a0\u901f\u5c0d\u827e\u52a0\u83ab\u5fb7(FcRn)\u3001povetacicept (APRIL\/BAFF) \u548c ZL-1108 (IGF-1R) \u7684\u81e8\u5e8a\u958b\u767c\uff0c\u5176\u4e2d\u5e7e\u9805\u9069\u61c9\u8b49\u8655\u65bc\u8a3b\u518a\u6027\u81e8\u5e8a\u7814\u7a76\u968e\u6bb5 <\/p>\n

\u81e8\u5e8a\u6578\u64da\u548c\u8a3b\u518a\u4e8b\u52d9\u9032\u5c55<\/p>\n

ZL-1310\uff08DLL3 ADC\uff09\u7528\u65bc\u4e8c\u7dda\u53ca\u4ee5\u4e0aSCLC\u548c\u4e00\u7ddaSCLC\u81e8\u5e8a\u7814\u7a76\u7684\u6578\u64da\u516c\u4f48 \u9810\u8a08\u5c07\u65bc2025 \u5e74\u4e0a\u534a\u5e74\u516c\u4f48\u8c9d\u746a\u59a5\u73e0\u55ae\u6297\u7528\u65bc\u80c3\u764c\u4e00\u7dda\u6cbb\u7642\u7684 3 \u671f\u7814\u7a76\u6578\u64da\uff0c\u4e26\u6709\u671b\u5411 NMPA \u63d0\u4ea4\u751f\u7269\u88fd\u54c1\u4e0a\u5e02\u8a31\u53ef\u7533\u8acb\uff08BLA\uff09 \u6709\u671b\u5411NMPA\u63d0\u4ea4\u816b\u7624\u96fb\u5834\u6cbb\u7642 (TTFields) \u7528\u65bc\u4e8c\u7dda\u53ca\u4ee5\u4e0a\u975e\u5c0f\u7d30\u80de\u80ba\u764c (NSCLC) \u548c\u4e00\u7dda\u80f0\u817a\u764c\u7684\u4e0a\u5e02\u8a31\u53ef\u7533\u8acb <\/p>\n

2025\u5e74\u696d\u7e3e\u6307\u5f15<\/p>\n

\u518d\u9f0e\u91ab\u85e5\u9810\u8a08\u5c07\u7e7c\u7e8c\u63a1\u53d6\u5be9\u614e\u7684\u8ca1\u52d9\u652f\u51fa\u4e26\u4e14\uff1a<\/p>\n

2025 \u5e74\u5168\u5e74\u7e3d\u6536\u5165\u9054\u52305.60\u5104\u7f8e\u5143\u81f35.90\u5104\u7f8e\u5143\u9593\u3002 \u5230 2025 \u5e74\u7b2c\u56db\u5b63\u5ea6\u5be6\u73fe\u975e\u7f8e\u570b\u516c\u8a8d\u6703\u8a08\u6e96\u5247\u7d93\u71df\u5229\u6f64\u76c8\u5229[1]<\/p>\n

\n

[1]\u975e\u7f8e\u570b\u516c\u8a8d\u6703\u8a08\u6e96\u5247\u7d93\u71df\u5229\u6f64\u76c8\u5229\u6307\u8abf\u6574\u5f8c\u7684\u7d93\u71df\u6536\u5165\uff08\u975e\u7f8e\u570b\u516c\u8a8d\u6703\u8a08\u6e96\u5247\uff09\uff0c\u8a08\u7b97\u65b9\u6cd5\u70ba\u5c07\u7f8e\u570b\u516c\u8a8d\u6703\u8a08\u6e96\u5247\u7d93\u71df\u6536\u5165\uff08\u8667\u640d\uff09\u7d93\u904e\u6263\u9664\u975e\u73fe\u91d1\u652f\u51fa\uff08\u5305\u62ec\u6298\u820a\u3001\u6524\u92b7\u548c\u4ee5\u80a1\u4efd\u70ba\u57fa\u790e\u7684\u916c\u91d1\uff09\u7684\u8abf\u6574\u3002\u6709\u95dc\u6b64\u8abf\u6574\u5f8c\u7684\u76c8\u5229\u6307\u6a19\u7684\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u53c3\u95b1\u300d\u975e\u7f8e\u570b\u516c\u8a8d\u6703\u8a08\u6e96\u5247\u6307\u6a19\u300d\u90e8\u5206\u3002<\/span><\/p>\n<\/div>\n

\u516c\u53f8\u9032\u5c55<\/p>\n

\u81ea\u4e0a\u6b21\u8ca1\u5831\u767c\u4f48\u4ee5\u4f86\u518d\u9f0e\u91ab\u85e5\u7684\u95dc\u9375\u516c\u53f8\u9032\u5c55\u5305\u62ec\uff1a<\/p>\n

\u696d\u52d9\u62d3\u5c55\uff1a
\n\u6211\u5011\u901a\u904e\u5177\u6709\u5354\u540c\u6548\u61c9\u7684\u696d\u52d9\u62d3\u5c55\u64f4\u5927\u548c\u52a0\u5f37\u4e86\u64c1\u6709\u5168\u7403\u548c\u5340\u57df\u6b0a\u5229\u7684\u7522\u54c1\u7ba1\u7dda\uff0c\u5176\u4e2d\u5305\u62ec\u8207\u5b9c\u806f\u751f\u7269\u9054\u6210\u6230\u7565\u5408\u4f5c\u53ca\u5168\u7403\u8a31\u53ef\u5354\u8b70\uff0c\u4ee5\u5229\u7528\u5b9c\u806f\u751f\u7269\u7684\u00a0TMALIN ADC \u5e73\u53f0\u958b\u767c\u00a0ZL-6201\uff0c\u9019\u662f\u4e00\u6b3e\u65b0\u578b\u7684\u3001\u5177\u6709\u540c\u985e\u9996\u5275\u6f5b\u529b\u7684LRRC15 ADC\uff0c\u7531\u518d\u9f0e\u91ab\u85e5\u767c\u73fe\u7684\u4e00\u6b3e\u6297\u9ad4\u7d44\u6210\uff0c\u7528\u65bc\u6cbb\u7642\u7279\u5b9a\u5be6\u9ad4\u7624\uff1b\u8207\u00a0Vertex \u9054\u6210\u6230\u7565\u5408\u4f5c\uff0c\u7372\u5f97\u00a0povetacicept \u5728\u4e2d\u570b\u5167\u5730\u3001\u9999\u6e2f\u3001\u6fb3\u9580\u3001\u53f0\u7063\u5730\u5340\u548c\u65b0\u52a0\u5761\u7684\u6388\u6b0a\u8a31\u53ef\uff0c\u9019\u662f\u4e00\u6b3e\u7528\u65bc\u514d\u75ab\u7403\u86cb\u767dA\u814e\u75c5\uff08IgAN\uff09\u00a0\u548c\u5176\u4ed6\u00a0B \u7d30\u80de\u4ecb\u5c0e\u75be\u75c5\u7684\u6f5b\u5728\u540c\u985e\u6700\u4f73\u6cbb\u7642\u85e5\u7269\uff1b\u5f9e\u00a0Zenas BioPharma \u7372\u5f97\u00a0ZL-1108\uff08veligrotug\uff09\u5728\u4e2d\u570b\u5167\u5730\u3001\u9999\u6e2f\u3001\u6fb3\u9580\u3001\u53f0\u7063\u5730\u5340\u548c\u65b0\u52a0\u5761\u7684\u6388\u6b0a\u8a31\u53ef\uff0c\u9019\u662f\u4e00\u6b3e\u5177\u6709\u5dee\u7570\u6027\u7684\u7684\u3001\u91dd\u5c0dIGF-1R\u7684\u4eba\u6e90\u5316\u55ae\u514b\u9686\u6297\u9ad4\uff0c\u7528\u65bc\u6cbb\u7642\u7532\u72c0\u817a\u773c\u75c5\uff08TED\uff09\u3002 \u6211\u5011\u9084\u8207\u8f1d\u745e\u5c31\u65b0\u578b\u6297\u611f\u67d3\u85e5\u7269\u9f0e\u512a\u6a02\u00ae\u00a0\uff08\u8212\u5df4\u5766\u9209-\u5ea6\u6d1b\u5df4\u5766\u9209\uff09\u9054\u6210\u6230\u7565\u5408\u4f5c\uff0c\u8a72\u85e5\u7269\u65bc2025\u5e741\u6708\u5728\u4e2d\u570b\u5167\u5730\u5546\u696d\u5316\u4e0a\u5e02\u3002\u901a\u904e\u6b64\u6b21\u5408\u4f5c\uff0c\u518d\u9f0e\u91ab\u85e5\u5c07\u501f\u52a9\u8f1d\u745e\u65d7\u4e0b\u516c\u53f8\u5728\u6297\u611f\u67d3\u9818\u57df\u884c\u696d\u9818\u5148\u7684\u5546\u696d\u5316\u80fd\u529b\uff0c\u52a9\u529b\u9019\u4e00\u91cd\u8981\u7642\u6cd5\u76e1\u5feb\u60e0\u53ca\u4e2d\u570b\u5167\u5730\u6709\u9700\u8981\u7684\u60a3\u8005\u3002 <\/p>\n

NRDL\u66f4\u65b0\uff1a2024 \u5e74 11 \u6708\uff0c\u518d\u9f0e\u91ab\u85e5\u5ba3\u4f48\u5967\u51f1\u6a02\u00ae\uff08\u745e\u666e\u66ff\u5c3c\uff09\u88ab\u7d0d\u5165NRDL\u7528\u65bc\u6cbb\u7642ROS1\u967d\u6027NSCLC\uff1b\u6210\u529f\u7e8c\u7d04\u7d10\u518d\u6a02\u00ae\uff08\u5967\u99ac\u74b0\u7d20\uff09\u7528\u65bc\u6cbb\u7642 CABP \u548c ABSSSI\uff0c\u4ee5\u53ca\u64ce\u6a02\u00ae\uff08\u745e\u6d3e\u66ff\u5c3c\uff09\u7528\u65bc\u6cbb\u7642\u56db\u7dda\u53ca\u4ee5\u4e0a\u80c3\u8178\u9593\u8cea\u7624 (GIST) \u60a3\u8005\u3002
\n\u8cc7\u672c\u5e02\u5834\uff1a2024 \u5e74 11 \u6708\uff0c\u518d\u9f0e\u91ab\u85e5\u5b8c\u6210\u4e86ADS\u7684\u516c\u958b\u767c\u884c\uff0c\u5728\u6263\u9664\u5305\u92b7\u5546\u6298\u6263\u3001\u4f63\u91d1\u53ca\u5176\u4ed6\u516c\u53f8\u61c9\u4ed8\u7684\u767c\u552e\u8cbb\u7528\u5f8c\uff0c\u516c\u53f8\u672c\u6b21\u767c\u552e\u7684\u5408\u8a08\u6240\u5f97\u6b3e\u9805\u6de8\u984d\u7d04\u70ba2.151\u5104\u7f8e\u5143\u3002 <\/p>\n

\u8fd1\u671f\u7ba1\u7dda\u4eae\u9ede<\/p>\n

\u81ea\u4e0a\u6b21\u8ca1\u5831\u767c\u4f48\u4ee5\u4f86\u518d\u9f0e\u91ab\u85e5\u7684\u95dc\u9375\u7522\u54c1\u9032\u5c55\u5305\u62ec\uff1a<\/p>\n

\u816b\u7624\u9818\u57df\u7ba1\u7dda<\/p>\n

ZL-1310 (DLL3 ADC)\uff1a2025 \u5e74 1 \u6708\uff0cFDA\u6388\u4e88 ZL-1310 \u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff0c\u7528\u65bc\u6cbb\u7642 SCLC\u3002ZL-1310 \u7372\u5f97\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff0c\u662f\u5c0d\u9019\u6b3e\u85e5\u7269\u7528\u65bc\u6cbb\u7642SCLC\u6f5b\u529b\u7684\u8a8d\u53ef\uff0c\u4e26\u4e14 ZL-1310 \u5c07\u6709\u8cc7\u683c\u7372\u5f97\u67d0\u4e9b\u958b\u767c\u6fc0\u52f5\u63aa\u65bd\uff0c\u5305\u62ec\u5728\u7522\u54c1\u7372\u6279\u5f8c\u6709\u53ef\u80fd\u7372\u5f97 FDA \u6388\u4e88\u7684 7 \u5e74\u7f8e\u570b\u5e02\u5834\u7368\u4f54\u671f\u3002
\n\u816b\u7624\u96fb\u5834\u6cbb\u7642\uff08TTFields\uff09\uff1a2024 \u5e74 12 \u6708\uff0c\u518d\u9f0e\u91ab\u85e5\u8207\u5408\u4f5c\u5925\u4f34 Novocure \u5ba3\u4f48\uff0c\u91dd\u5c0d\u80f0\u817a\u764c\u7684\u95dc\u9375\u6027 3 \u671f\u81e8\u5e8a\u7814\u7a76PANOVA-3\u9054\u5230\u4e86\u4e3b\u8981\u7d42\u9ede\uff0c\u8207\u5c0d\u7167\u7d44\u76f8\u6bd4\uff0c\u5728\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\u4e0a\u986f\u793a\u51fa\u7d71\u8a08\u5b78\u610f\u7fa9\u4e0a\u7684\u986f\u8457\u6539\u5584\u3002PANOVA-3\u662f\u9996\u500b\u4e5f\u662f\u76ee\u524d\u552f\u4e00\u4e00\u500b\u5728\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u80f0\u817a\u764c\u4e2d\u986f\u793a\u51fa\u7e3d\u751f\u5b58\u671f\u7d71\u8a08\u5b78\u610f\u7fa9\u4e0a\u986f\u8457\u7372\u76ca\u76843\u671f\u7814\u7a76\u3002\u518d\u9f0e\u91ab\u85e5\u5728\u5927\u4e2d\u83ef\u5340\u53c3\u8207\u4e86\u9019\u4e00\u7814\u7a76\uff0c\u4e26\u8a08\u5283\u65bc 2025 \u5e74\u4e0b\u534a\u5e74\u5728\u4e2d\u570b\u63d0\u4ea4\u4e0a\u5e02\u8a31\u53ef\u7533\u8acb \u3002
\n\u7dad\u66ff\u7d22\u59a5\u5c24\u55ae\u6297\uff08\u7d44\u7e54\u56e0\u5b50 ADC\uff09\uff1a2025 \u5e74 1 \u6708\uff0c\u518d\u9f0e\u91ab\u85e5\u5ba3\u4f48\u4e86\u5168\u7403 3 \u671f\u7814\u7a76 innovaTV 301\u4e2d\u570b\u4e9e\u7d44\u7684\u967d\u6027\u4e3b\u8981\u7d50\u679c\uff0c\u8207\u5316\u7642\u76f8\u6bd4\uff0c\u7dad\u66ff\u7d22\u59a5\u5c24\u55ae\u6297\u5728\u4e4b\u524d\u63a5\u53d7\u904e\u6cbb\u7642\u7684\u5fa9\u767c\u6216\u8f49\u79fb\u6027\u5bae\u9838\u764c\u60a3\u8005\u4e2d\uff0c\u986f\u793a\u51fa\u5177\u6709\u81e8\u5e8a\u610f\u7fa9\u7684\u7e3d\u751f\u5b58\u671f\u6539\u5584\u3002\u518d\u9f0e\u91ab\u85e5\u8a08\u5283\u57282025\u5e74\u7b2c\u4e00\u5b63\u5ea6\u5411NMPA\u63d0\u4ea4\u7dad\u66ff\u7d22\u59a5\u5c24\u55ae\u6297\u7684NDA\uff0c\u5982\u679c\u7372\u6279\u5c07\u5229\u7528\u73fe\u6709\u5247\u6a02\u5728\u5a66\u7624\u9818\u57df\u7684\u5546\u696d\u5316\u4f48\u5c40\uff0c\u52a0\u901f\u9019\u6b3e\u85e5\u7269\u5728\u4e2d\u570b\u60e0\u53ca\u60a3\u8005\u3002
\n\u745e\u666e\u66ff\u5c3c\uff08ROS1\/TRK\uff09\uff1a2025 \u5e74 2 \u6708\uff0c\u4e2d\u570bNMPA\u5c07\u745e\u666e\u66ff\u5c3c\u7d0d\u5165\u512a\u5148\u5be9\u8a55\uff0c\u7528\u65bc\u6cbb\u7642 NTRK \u57fa\u56e0\u878d\u5408\u7684\u665a\u671f\u5be6\u9ad4\u7624\u60a3\u8005\u3002\u518d\u9f0e\u91ab\u85e5\u8a08\u5283\u65bc 2025 \u5e74\u4e0a\u534a\u5e74\u5411NMPA\u63d0\u4ea4\u88dc\u5145NDA\u3002 <\/p>\n

\u514d\u75ab\u3001\u795e\u7d93\u79d1\u5b78\u548c\u611f\u67d3\u6027\u75be\u75c5\u7ba1\u7dda<\/p>\n

\u827e\u52a0\u83ab\u5fb7 (FcRn)\uff1a2024\u5e7411\u6708\uff0c\u518d\u9f0e\u91ab\u85e5\u5408\u4f5c\u5925\u4f34argenx\u5ba3\u4f48\uff0c\u6c7a\u5b9a\u5728\u6b63\u5728\u9032\u884c\u76842\/3\u671f\u81e8\u5e8a\u7814\u7a76ALKIVIA \u4e2d\u63a8\u9032\u827e\u52a0\u83ab\u5fb7\u76ae\u4e0b\u6ce8\u5c04\u5291\u578b\uff08efgartigimod SC\uff09\u7528\u65bc\u6cbb\u7642\u7279\u767c\u6027\u708e\u6027\u808c\u75c5\uff08IIM\uff0c\u808c\u708e\uff09\u7684\u81e8\u5e8a\u958b\u767c\uff0c\u9019\u4e00\u6c7a\u5b9a\u662f\u5728\u5206\u6790\u4e86\u8a72\u7814\u7a76\u76842\u671f\u90e8\u5206\u7684\u4e3b\u8981\u6578\u64da\u5f8c\u505a\u51fa\u7684\u3002\u518d\u9f0e\u91ab\u85e5\u6b63\u5728\u5927\u4e2d\u83ef\u5340\u53c3\u8207\u9019\u9805\u7814\u7a76\u3002
\n\u546b\u8afe\u7f8e\u6797\u66f2\u53f8\u6c2f\u92a8(KarXT)\uff08M1\/M4\u578b\u6bd2\u8548\u9e7c\u4e59\u9170\u81bd\u9e7c\u53d7\u9ad4\u6fc0\u52d5\u5291\uff09\uff1a2025\u5e741\u6708\uff0c\u4e2d\u570bNMPA\u53d7\u7406\u4e86KarXT\u7528\u65bc\u7cbe\u795e\u5206\u88c2\u75c7\u6210\u4eba\u60a3\u8005\u7684NDA\u3002\u5982\u679c\u7372\u6279\uff0c KarXT\u6709\u671b\u70ba\u4e2d\u570b\u5167\u5730\u7684\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005\u91cd\u65b0\u5b9a\u7fa9\u9019\u4e00\u75be\u75c5\u9818\u57df\u7684\u6cbb\u7642\u3002 <\/p>\n

2025\u5e74\u7684\u9810\u671f\u91cd\u8981\u91cc\u7a0b\u7891<\/p>\n

\u6709\u671b\u8fd1\u671f\u5411NMPA\u905e\u4ea4\u7684\u4e0a\u5e02\u7533\u8acb<\/p>\n

\u7dad\u66ff\u7d22\u59a5\u5c24\u55ae\u6297\uff08\u7d44\u7e54\u56e0\u5b50 ADC\uff09\uff1a2025 \u5e74\u7b2c\u4e00\u5b63\u5ea6\u63d0\u4ea4\u7528\u65bc\u5316\u7642\u671f\u9593\u6216\u5316\u7642\u5f8c\u51fa\u73fe\u9032\u5c55\u7684\u5fa9\u767c\u6027\u6216\u8f49\u79fb\u6027\u5bae\u9838\u764c\u7684 BLA \u3002
\n\u8c9d\u746a\u59a5\u73e0\u55ae\u6297\uff08FGFR2b\uff09\uff1a2025\u5e74\u4e0a\u534a\u5e74\u63d0\u4ea4\u7528\u65bc\u80c3\u764c\u4e00\u7dda\u6cbb\u7642\u7684BLA\u3002
\n\u745e\u666e\u66ff\u5c3c\uff08ROS1\/TRK\uff09\uff1a2025\u5e74\u4e0a\u534a\u5e74\u63d0\u4ea4\u7528\u65bcNTRK\u967d\u6027\u5be6\u9ad4\u7624\u7684\u88dc\u5145NDA\u3002
\n\u816b\u7624\u96fb\u5834\u6cbb\u7642\uff08TTFields\uff09\uff1a\u63d0\u4ea4\u7528\u65bc\u63a5\u53d7\u542b\u9251\u5316\u7642\u671f\u9593\u6216\u4e4b\u5f8c\u51fa\u73fe\u9032\u5c55\u7684\u4e8c\u7dda\u53ca\u4ee5\u4e0a NSCLC\u7684\u4e0a\u5e02\u8a31\u53ef\u7533\u8acb\uff0c\u63d0\u4ea4\u7528\u65bc\u80f0\u817a\u764c\u4e00\u7dda\u6cbb\u7642\u7684\u4e0a\u5e02\u8a31\u53ef\u7533\u8acb\u3002 <\/p>\n

2025\u5e74\u7684\u9810\u671f\u81e8\u5e8a\u958b\u767c\u548c\u6578\u64da\u516c\u4f48<\/p>\n

\u5168\u7403\u6b0a\u5229\u7ba1\u7dda<\/p>\n

ZL-1310 (DLL3 ADC)<\/p>\n

\u4e8c\u7dda\u53ca\u4ee5\u4e0a\u5ee3\u6cdb\u671fSCLC\uff08ES-SCLC\uff09\uff1a\u518d\u9f0e\u91ab\u85e5\u5c07\u57282025\u5e74\u4e0a\u534a\u5e74\u7684\u91cd\u8981\u91ab\u5b78\u6703\u8b70\u4e0a\u516c\u4f48ZL-1310\u7684\u6578\u64da\u66f4\u65b0\u3002\u518d\u9f0e\u91ab\u85e5\u8a08\u5283\u57282025\u5e74\u555f\u52d5\u4e00\u9805\u95dc\u9375\u81e8\u5e8a\u7814\u7a76\u3002
\n\u4e00\u7dda\u5ee3\u6cdb\u671fSCLC\uff08ES-SCLC\uff09\uff1a\u518d\u9f0e\u91ab\u85e5\u5c07\u516c\u4f48ZL-1310\u8207\u963f\u66ff\u5229\u73e0\u55ae\u6297\u806f\u7528\u7684\u5291\u91cf\u905e\u589e\u6578\u64da\uff0c\u4e26\u555f\u52d5ZL-1310\u806f\u5408\u963f\u66ff\u5229\u73e0\u55ae\u6297\u53ca\u542b\u9251\u5316\u7642\u7684\u5291\u91cf\u905e\u589e\u7814\u7a76\u3002
\n\u5176\u5b83\u795e\u7d93\u5167\u5206\u6ccc\u816b\u7624\uff1a\u518d\u9f0e\u91ab\u85e5\u5c07\u57282025\u5e74\u4e0a\u534a\u5e74\u555f\u52d5\u4e00\u9805\u5168\u74031\u671f\u81e8\u5e8a\u7814\u7a76\u3002 <\/p>\n

ZL-1102 (IL-17 Humabody\u00ae)<\/p>\n

\u518d\u9f0e\u91ab\u85e5\u5c07\u5728 2025 \u5e74\u4e0a\u534a\u5e74\u516c\u4f48\u7528\u65bc\u6162\u6027\u6591\u584a\u72c0\u9280\u5c51\u75c5\u7684\u5168\u7403 2 \u671f\u7814\u7a76\u7684\u4e2d\u671f\u5206\u6790\u3002 <\/p>\n

ZL-1503 (IL-13\/IL-31R)<\/p>\n

\u518d\u9f0e\u91ab\u85e5\u5c07\u516c\u4f48\u66f4\u65b0\u7684\u81e8\u5e8a\u524d\u6578\u64da\u4e26\u555f\u52d5\u7528\u65bc\u4e2d\u91cd\u5ea6\u7279\u61c9\u6027\u76ae\u708e\u7684\u5168\u7403 1 \u671f\u7814\u7a76\u3002 <\/p>\n

ZL-6201 (LRRC15 ADC)<\/p>\n

\u518d\u9f0e\u91ab\u85e5\u5c07\u516c\u4f48\u66f4\u65b0\u7684\u81e8\u5e8a\u524d\u6578\u64da\u4e26\u555f\u52d5\u7528\u65bc\u8089\u7624\u7684\u5168\u74031\u671f\u7814\u7a76\u3002 <\/p>\n

\u5340\u57df\u6b0a\u5229\u7ba1\u7dda<\/p>\n

\u8c9d\u746a\u59a5\u73e0\u55ae\u6297(FGFR2b)<\/p>\n

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