{"id":24230,"date":"2025-01-10T15:17:00","date_gmt":"2025-01-10T07:17:00","guid":{"rendered":"https:\/\/www.franchise.com.hk\/%e5%86%8d%e9%bc%8e%e9%86%ab%e8%97%a5%e8%88%87vertex%e5%ae%a3%e5%b8%83%e5%b0%b1povetacicept%e5%9c%a8%e5%a4%a7%e4%b8%ad%e8%8f%af%e5%8d%80%e5%92%8c%e6%96%b0%e5%8a%a0%e5%9d%a1%e9%96%8b%e7%99%bc%e5%92%8c\/24230"},"modified":"2025-01-10T15:17:00","modified_gmt":"2025-01-10T07:17:00","slug":"%e5%86%8d%e9%bc%8e%e9%86%ab%e8%97%a5%e8%88%87vertex%e5%ae%a3%e5%b8%83%e5%b0%b1povetacicept%e5%9c%a8%e5%a4%a7%e4%b8%ad%e8%8f%af%e5%8d%80%e5%92%8c%e6%96%b0%e5%8a%a0%e5%9d%a1%e9%96%8b%e7%99%bc%e5%92%8c","status":"publish","type":"post","link":"https:\/\/www.franchise.com.hk\/zh-hans\/%e5%86%8d%e9%bc%8e%e9%86%ab%e8%97%a5%e8%88%87vertex%e5%ae%a3%e5%b8%83%e5%b0%b1povetacicept%e5%9c%a8%e5%a4%a7%e4%b8%ad%e8%8f%af%e5%8d%80%e5%92%8c%e6%96%b0%e5%8a%a0%e5%9d%a1%e9%96%8b%e7%99%bc%e5%92%8c\/24230","title":{"rendered":"\u518d\u9f0e\u91ab\u85e5\u8207Vertex\u5ba3\u5e03\u5c31povetacicept\u5728\u5927\u4e2d\u83ef\u5340\u548c\u65b0\u52a0\u5761\u958b\u767c\u548c\u5546\u696d\u5316\u9054\u6210\u6230\u7565\u5354\u8b70"},"content":{"rendered":"

-\u5728\u76f8\u95dc\u5340\u57df\u5c31povetacicept\u9054\u6210\u7368\u5bb6\u5408\u4f5c\u8207\u8a31\u53ef\u5354\u8b70\u00a0<\/p>\n

-\u518d\u9f0e\u91ab\u85e5\u5c07\u5229\u7528\u5176\u672c\u5730\u5c08\u9577\u548c\u5546\u696d\u5316\u5e03\u5c40\u4f86\u52a0\u901fpovetacicept\u7684\u958b\u767c\uff0c\u4e26\u5728\u7522\u54c1\u7372\u6279\u5f8c\u5e36\u7d66\u76f8\u95dc\u5340\u57df\u9069\u5408\u7684\u60a3\u8005<\/p>\n

\u7f8e\u570b\u6ce2\u58eb\u9813\u3001\u4e2d\u570b\u4e0a\u6d77\u548c\u7f8e\u570b\u99ac\u85a9\u8af8\u585e\u5dde\u528d\u6a4b<\/span>2025\u5e741\u670810\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u518d\u9f0e\u91ab\u85e5\uff08\u7d0d\u65af\u9054\u514b\u80a1\u7968\u4ee3\u78bc\uff1aZLAB\uff1b\u9999\u6e2f\u806f\u4ea4\u6240\u80a1\u4efd\u4ee3\u865f\uff1a9688\uff09\u548cVertex Pharmaceuticals Incorporated\uff08\u7d0d\u65af\u9054\u514b\u80a1\u7968\u4ee3\u78bc\uff1aVRTX\uff09\u4eca\u65e5\u5ba3\u5e03\u9054\u6210\u7368\u5bb6\u5408\u4f5c\u548c\u8a31\u53ef\u5354\u8b70\uff0c\u5728\u5927\u4e2d\u83ef\u5340\uff08\u4e2d\u570b\u5167\u5730\u3001\u9999\u6e2f\u3001\u6fb3\u9580\u548c\u53f0\u7063\u5730\u5340\uff09\u548c\u65b0\u52a0\u5761\uff08\u7d71\u7a31\u70ba\u300c\u8a31\u53ef\u5340\u57df\u300d\uff09\u958b\u767c\u548c\u5546\u696d\u5316Vertex\u7684povetacicept\uff08pove\uff09\u3002Pove\u662f\u4e00\u6b3e\u6f5b\u5728\u540c\u985e\u6700\u512a\u7684\u91cd\u7d44\u878d\u5408\u86cb\u767d\u6cbb\u7642\uff0c\u662fBAFF\uff08B\u7d30\u80de\u6d3b\u5316\u56e0\u5b50\uff09\u548cAPRIL\uff08\u589e\u6b96\u8a98\u5c0e\u914d\u9ad4\uff09\u7684\u96d9\u91cd\u62ee\u6297\u5291\uff0c\u6b63\u5728\u7814\u7a76\u7528\u65bc\u6cbb\u7642\u514d\u75ab\u7403\u86cb\u767dA\u814e\u75c5\uff08IgA\u814e\u75c5\uff09\u548c\u5176\u4ed6B\u7d30\u80de\u4ecb\u5c0e\u7684\u75be\u75c5\u3002<\/p>\n

\u6839\u64da\u5354\u8b70\u689d\u6b3e\uff0cVertex \u5c07\u7372\u5f97\u4e00\u7b46\u9810\u4ed8\u6b3e\uff0c\u4ee5\u53ca\u57fa\u65bc\u6ce8\u518a\u7684\u88e1\u7a0b\u7891\u4ed8\u6b3e\u548c\u518d\u9f0e\u91ab\u85e5\u91cd\u9ede\u5340\u57df\u6de8\u92b7\u552e\u984d\u7684\u5206\u7d1a\u7279\u8a31\u6b0a\u4f7f\u7528\u8cbb\u3002\u518d\u9f0e\u91ab\u85e5\u5c07\u501f\u52a9\u5176\u7814\u767c\u65b9\u9762\u7684\u7d93\u9a57\u63a8\u9032\u8a72\u7522\u54c1\u5728\u8a31\u53ef\u5340\u57df\u7684\u81e8\u5e8a\u7814\u7a76\u548c\u6ce8\u518a\u905e\u4ea4\u3002\u4e00\u65e6pove\u7372\u6279\uff0c\u518d\u9f0e\u91ab\u85e5\u5c07\u501f\u52a9\u5176\u5f37\u5927\u7684\u5546\u696d\u5316\u5e03\u5c40\uff0c\u8ca0\u8cac\u8a31\u53ef\u5340\u57df\u5167\u7684\u6240\u6709\u5546\u696d\u5316\u6d3b\u52d5\u3002\u00a0<\/p>\n

Vertex \u9996\u5e2d\u57f7\u884c\u5b98\u517c\u7e3d\u88c1Reshma Kewalramani \u535a\u58eb\u8868\u793a\uff1a\u300c\u518d\u9f0e\u6df1\u539a\u7684\u7814\u767c\u548c\u5546\u696d\u5316\u80fd\u529b\uff0c\u4ee5\u53ca\u5728\u76f8\u95dc\u5340\u57df\u7684\u5e03\u5c40\uff0c\u4f7f\u5176\u6210\u70ba\u6211\u5011\u52aa\u529b\u8b93pove\u60e0\u53ca\u4e2d\u570b\u53ca\u66f4\u591a\u5730\u5340\u60a3\u8005\u904e\u7a0b\u4e2d\u7406\u60f3\u7684\u5408\u4f5c\u4f19\u4f34\u3002\u6211\u5011\u975e\u5e38\u9ad8\u8208\u80fd\u8207\u518d\u9f0e\u5408\u4f5c\uff0c\u9019\u5c07\u8ce6\u80fd\u6211\u5011\u52a0\u901f\u628a\u9019\u6b3e\u6f5b\u5728\u540c\u985e\u6700\u512a\u7642\u6cd5\u5e36\u7d66\u6b63\u5728\u7b49\u5f85\u7684\u60a3\u8005\u3002\u300d\u00a0<\/p>\n

\u518d\u9f0e\u91ab\u85e5\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u9577\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u675c\u7469\u535a\u58eb\u8868\u793a\uff1a\u300c Pove\u662f\u5c0d\u6211\u5011\u73fe\u6709\u7522\u54c1\u7d44\u5408\u7684\u91cd\u8981\u64f4\u5c55\uff0c\u5c07\u7e7c\u7e8c\u978f\u56fa\u6211\u5011\u5728\u4e2d\u570b\u514d\u75ab\u9818\u57df\u7684\u9818\u5148\u5730\u4f4d\u3002\u6211\u5011\u81f4\u529b\u65bc\u70ba\u6709\u9700\u8981\u7684\u60a3\u8005\u63d0\u4f9b\u5275\u65b0\u7642\u6cd5\uff0c\u5f88\u9ad8\u8208\u8207 Vertex \u5408\u4f5c\uff0c\u8b93\u4e2d\u570b\u53ca\u5176\u4ed6\u66f4\u591a\u5730\u5340\u7684\u60a3\u8005\u80fd\u5920\u7528\u4e0aPove \u3002\u300d<\/p>\n

\u95dc\u65bcPovetacicept<\/p>\n

Povetacicept\u662f\u4e00\u7a2e\u91cd\u7d44\u878d\u5408\u86cb\u767d\u6cbb\u7642\uff0c\u662f\u00a0BAFF\uff08B \u7d30\u80de\u6d3b\u5316\u56e0\u5b50\uff09\u548c\u00a0APRIL\uff08\u589e\u6b96\u8a98\u5c0e\u914d\u9ad4\uff09\u7684\u96d9\u91cd\u62ee\u6297\u5291\uff0c\u9019\u5e7e\u7a2e\u7d30\u80de\u56e0\u5b50\u901a\u904e\u5176\u5728\u00a0B \u7d30\u80de\u3001T \u7d30\u80de\u548c\u5148\u5929\u514d\u75ab\u7d30\u80de\u7684\u6fc0\u6d3b\u3001\u5206\u5316\u548c\/\u6216\u5b58\u6d3b\u4e2d\u7684\u4f5c\u7528\uff0c\u5728\u591a\u7a2e\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7684\u767c\u75c5\u6a5f\u5236\u4e2d\u767c\u63ee\u95dc\u9375\u4f5c\u7528\u3002\u57fa\u65bc\u5de5\u7a0b\u5316\u7684\u00a0TACI\uff08\u8de8\u819c\u6fc0\u6d3b\u5291\u53ca\u9223\u8abf\u89aa\u74b0\u7d20\u914d\u9ad4\u76f8\u4e92\u4f5c\u7528\u5206\u5b50\u00a0\uff09\u7d50\u69cb\u57df\uff0c\u00a0povetacicept\u5728\u81e8\u5e8a\u524d\u7814\u7a76\u4e2d\u8207\u5176\u4ed6\u00a0BAFF \u548c\/\u6216APRIL\u6291\u5236\u5291\u76f8\u6bd4\u5177\u6709\u66f4\u9ad8\u7684\u7d50\u5408\u89aa\u548c\u529b\u548c\u66f4\u5f37\u7684\u6548\u529b\uff0c\u4e26\u4e14\u5728\u00a0IgA \u814e\u75c5\u548c\u539f\u767c\u6027\u819c\u6027\u814e\u75c5\u60a3\u8005\u7684\u81e8\u5e8a\u7814\u7a76\u4e2d\u8868\u73fe\u51fa\u6f5b\u5728\u7684\u540c\u985e\u6700\u512a\u7642\u6548\u3002Povetacicept\u9084\u6b63\u5728\u958b\u767c\u7528\u65bc\u6cbb\u7642\u591a\u7a2e\u00a0B\u7d30\u80de\u4ecb\u5c0e\u7684\u56b4\u91cd\u75be\u75c5\uff0c\u5305\u62ec\u5176\u4ed6\u81ea\u8eab\u514d\u75ab\u6027\u814e\u9ad2\u75be\u75c5\u548c\u81ea\u8eab\u514d\u75ab\u6027\u8840\u7d30\u80de\u6e1b\u5c11\u75c7\u3002<\/p>\n

\u95dc\u65bc\u00a0IgA \u814e\u75c5\u00a0<\/p>\n

IgA\u814e\u75c5\u662f\u4e00\u7a2e\u56b4\u91cd\u7684\u3001\u9032\u884c\u6027\u7684\u3001\u5371\u53ca\u751f\u547d\u7684\u00a0B \u7d30\u80de\u4ecb\u5c0e\u7684\u6162\u6027\u814e\u9ad2\u75be\u75c5\uff0c\u662f\u539f\u767c\u6027\uff08\u7279\u767c\u6027\uff09\u814e\u5c0f\u7403\u814e\u708e\u7684\u6700\u5e38\u898b\u75c5\u56e0\uff0c\u64da\u4f30\u8a08\uff0c\u4e2d\u570b\u6709\u7d04300\u842c\u5230500\u842cIgA\u814e\u75c5\u60a3\u80051-5\u3002\u00a0IgA\u814e\u75c5\u662f\u7531\u514d\u75ab\u7403\u86cb\u767d\uff08Ig\uff09\u548c\u534a\u4e73\u7cd6\u7f3a\u4e4f\u7684IgA1 (Gd-IgA1)\u5faa\u74b0\u514d\u75ab\u5fa9\u5408\u7269\u5728\u814e\u5c0f\u7403\u7cfb\u819c\u4e2d\u6c89\u7a4d\u5f15\u8d77\u7684\uff0c\u9032\u800c\u5f15\u767c\u814e\u9ad2\u640d\u50b7\u548c\u7e96\u7dad\u5316\u3002\u5f88\u5927\u6bd4\u4f8b\u7684IgA\u814e\u75c5\u60a3\u8005\u6703\u767c\u5c55\u70ba\u7d42\u672b\u671f\u814e\u75c5\u3002\u76ee\u524d\u5c1a\u7121\u7279\u7570\u6027\u91dd\u5c0dIgA\u814e\u75c5\u7684\u81f4\u75c5\u539f\u56e0\u7684\u7642\u6cd5\u7372\u6279\u3002<\/p>\n

\u95dc\u65bcRAINIER<\/p>\n

RAINIER \u662f\u4e00\u9805\u5168\u7403\u00a03 \u671f\u95dc\u9375\u6027\u7814\u7a76\uff0c\u5728\u6a19\u51c6\u6cbb\u7642\u7684\u57fa\u790e\u4e0a\uff0c\u5728\u7d04\u00a0480 \u540dIgAN\u60a3\u8005\u4e2d\u7814\u7a76\u4f7f\u7528povetacicept 80 \u6beb\u514b\u5c0d\u6bd4\u5b89\u6170\u5291\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u8a72\u7814\u7a76\u5c07\u9032\u884c\u9810\u5148\u8a08\u5283\u7684\u4e2d\u671f\u5206\u6790\uff0c\u65e8\u5728\u8a55\u4f30\u4e00\u5b9a\u6578\u91cf\u7684\u60a3\u8005\u5b8c\u6210\u00a036 \u5468\u6cbb\u7642\u5f8c\u00a0povetacicept\u7d44\u8207\u5b89\u6170\u5291\u7d44\u7684\u5c3f\u86cb\u767d\u8207\u808c\u9150\u6bd4\u503c\uff08UPCR\uff09\u3002\u5982\u679c\u7d50\u679c\u70ba\u967d\u6027\uff0c\u4e2d\u671f\u5206\u6790\u53ef\u4f5c\u70ba\u00a0Vertex \u5728\u7f8e\u570b\u52a0\u901f\u6279\u51c6\u7684\u57fa\u790e\u3002\u6700\u7d42\u5206\u6790\u5c07\u5728\u6cbb\u7642\u5169\u5e74\u5f8c\u9032\u884c\uff0c\u4e3b\u8981\u7d42\u9ede\u70ba\u7b2c\u00a0104 \u5468\u7684\u7e3d\u00a0eGFR \u659c\u7387\u3002<\/p>\n

\u8a723\u671f\u81e8\u5e8a\u7814\u7a76\u6b63\u5728\u5305\u62ec\u7f8e\u570b\u3001\u6b50\u76df\u548c\u4e9e\u6d32\u7b49\u591a\u500b\u5730\u5340\u958b\u5c55\u3002\u5176\u4e2d\uff0c\u4e2d\u570b\u76e3\u7ba1\u6a5f\u69cb\u5df2\u6279\u51c6\u4e86RAINIER\u7684\u81e8\u5e8a\u8a66\u9a57\u7533\u8acb\uff08CTA\uff09\uff0c\u76ee\u524d\u7814\u7a76\u6b63\u5728\u9032\u884c\u4e2d\u3002<\/p>\n

\u95dc\u65bc\u00a0RUBY-3<\/p>\n

RUBY-3 \u662f\u4e00\u9805\u6b63\u5728\u9032\u884c\u7684\u3001\u591a\u5291\u91cf\u905e\u589e\u3001\u591a\u968a\u5217\u3001\u958b\u653e\u6a19\u7c3d\u3001\u00a01\/2 \u671f\u7c43\u5f0f\u7814\u7a76\uff0c\u7814\u7a76povetacicept\u5728\u81ea\u8eab\u514d\u75ab\u6027\u814e\u5c0f\u7403\u814e\u708e\uff08\u5305\u62ecIgA\u814e\u75c5\u00a0\u3001\u00a0\u539f\u767c\u6027\u819c\u6027\u814e\u75c5\u00a0\u3001\u72fc\u7621\u814e\u708e\u548c\u4f34\u6709\u814e\u5c0f\u7403\u814e\u708e\u7684\u00a0ANCA \u76f8\u95dc\u6027\u8840\u7ba1\u708e\uff09\u4e2d\u7684\u61c9\u7528\uff0c\u5176\u4e2dpovetacicept\u5c07\u4ee5\u76ae\u4e0b\u7d66\u85e5\u7684\u65b9\u5f0f\u7d66\u85e5\u6700\u591a\u81f3\u00a0104 \u5468\u3002<\/p>\n

\u95dc\u65bc\u518d\u9f0e\u91ab\u85e5<\/p>\n

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\u518d\u9f0e\u91ab\u85e5\u524d\u77bb\u6027\u8072\u660e<\/p>\n

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\n

1.Wang L, Xu X, Zhang M, Hu C, Zhang X, Li C, Nie S, Huang Z, Zhao Z, Hou FF, Zhou M. Prevalence of Chronic Kidney Disease in China: Results From the Sixth China Chronic Disease and Risk Factor Surveillance. JAMA Intern Med. 2023 Apr 1;183(4):298-310. doi: 10.1001\/jamainternmed.2022.6817. PMID: 36804760; PMCID: PMC9941971.<\/span><\/p>\n

2.Zhang L., Wang F., Wang L. et al. Prevalence of chronic kidney disease in China: a cross-sectional survey. The Lancet. 2012 March Volume 379, Issue 9818, 815 \u2013 822 doi: 10.1016\/S0140-6736(12)60033-6<\/span><\/p>\n

3.China Kidney Disease Network<\/span><\/p>\n

4.Hu, R., Quan, S., Wang, Y. et al. Spectrum of biopsy proven renal diseases in Central China: a 10-year retrospective study based on 34,630 cases. Sci Rep 10, 10994 (2020). https:\/\/doi.org\/10.1038\/s41598-020-67910-w<\/span><\/p>\n

5.Zheng L, Tu L, Huang H, Zhang L, Wang Y, Zhou J, Chen Q, Wei X. Changes in the spectrum of kidney diseases: a survey of 2803 patients from 2010 to 2018 at a single center in southeastern China. Ren Fail. 2022 Dec;44(1):987-993. doi: 10.1080\/0886022X.2022.2083517. PMID: 35656734; PMCID: PMC9176642.<\/span><\/p>\n<\/div>\n

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