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CS5001\u662f\u76ee\u524d\u5df2\u77e5\u9996\u500b\u5728\u5be6\u9ad4\u7624\u548c\u6dcb\u5df4\u7624\u4e2d\u5747\u89c0\u5bdf\u5230\u81e8\u5e8a\u7642\u6548\u7684ROR1 ADC\u3002\u672c\u6b21ASH\u516c\u4f48\u4e86CS5001\u4f5c\u70ba\u55ae\u85e5\u6cbb\u7642\u665a\u671f\u6dcb\u5df4\u7624\u7684\u81e8\u5e8a\u5b89\u5168\u6027\u548c\u7642\u6548\u6578\u64da\u3002 CS5001\u5728\u591a\u7dda\u7d93\u6cbb\u7684\u665a\u671fB\u7d30\u80de\u6dcb\u5df4\u7624\u60a3\u8005\u4e2d\u8868\u73fe\u51fa\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u622a\u81f3\u76ee\u524d\u572810\u500b\u5291\u91cf\u7d44\u4e2d\u672a\u5831\u544a\u6709\u5291\u91cf\u9650\u5236\u6027\u6bd2\u6027\uff08DLT\uff09\u3002 \u7121\u8ad6ROR1\u8868\u9054\u6c34\u5e73\u5982\u4f55\uff0c\u5f9e\u8d77\u6548\u5291\u91cf\u958b\u59cb\uff0cCS5001\u5728\u665a\u671f\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08HL\uff09\u4e2d\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u9054\u523060.0%\uff0c\u5728\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08NHL\uff09\u4e2dORR\u70ba56.3%\u3002\u5728\u521d\u6b65\u9078\u5b9a\u7684II\u671f\u63a8\u85a6\u5291\u91cf\uff08RP2D\uff09\u6c34\u5e73 \u2014\u2014 DL8\uff08125 \u03bcg\/kg\uff09\u7684\u665a\u671fB\u7d30\u80de\u6dcb\u5df4\u7624\u60a3\u8005\u4e2d\uff0cORR\u66f4\u662f\u9054\u5230\u4e8676.9%\uff08\u5176\u4e2d3\u4f8b\u53ef\u8a55\u4f30\u7684HL\u5747\u9054\u5230\u5b8c\u5168\u6216\u90e8\u5206\u7de9\u89e3\uff0cNHL\u7684ORR\u70ba70%\uff09\u3002 CS5001\u5168\u7403\u591a\u4e2d\u5fc3\u8a66\u9a57\u76ee\u524d\u4ecd\u5728\u7f8e\u570b\u3001\u6fb3\u5927\u5229\u4e9e\u548c\u4e2d\u570b\u540c\u6b65\u9032\u884c\uff0c\u76ee\u524d\u5291\u91cf\u905e\u589e\u5df2\u5b8c\u6210\uff0c\u8fd1\u671f\u6211\u5011\u5c07\u555f\u52d5\u6db5\u84cb\u591a\u7624\u7a2e\u3001\u5177\u6709\u8a3b\u518a\u6f5b\u529b\u76841b\u671f\u5291\u91cf\u64f4\u5c55\u7814\u7a76\u3002 <\/p>\n

\u8607\u5dde<\/span>2024\u5e7412\u67089\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u57fa\u77f3\u85e5\u696d\uff08\u80a1\u7968\u4ee3\u78bc\uff1a2616.HK\uff09\uff0c\u4e00\u5bb6\u5c08\u6ce8\u65bc\u6297\u816b\u7624\u85e5\u7269\u7814\u767c\u7684\u5275\u65b0\u9a45\u52d5\u578b\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u4eca\u65e5\u5ba3\u4f48\uff0c\u516c\u53f8\u5728\u7b2c66\u5c46\u7f8e\u570b\u8840\u6db2\u5b78\u6703\uff08ASH\uff09\u5e74\u6703\u4e0a\u516c\u4f48\u7ba1\u7dda2.0\u91cd\u78c5\u7522\u54c1CS5001\uff08ROR1 ADC\uff09\u91dd\u5c0d\u6dcb\u5df4\u7624\u7684\u6700\u65b0\u81e8\u5e8a\u6578\u64da\u3002<\/p>\n

\u53d7\u9ad4\u916a\u6c28\u9178\u6fc0\u9176\u6a23\u5b64\u5152\u53d7\u9ad41\uff08ROR1\uff09\u662f\u4e00\u7a2e\u80da\u80ce\u671f\u916a\u6c28\u9178\u6fc0\u9176\u6a23\u5206\u5b50\uff0c\u6d89\u53ca\u591a\u7a2e\u4fc3\u9032\u816b\u7624\u4fe1\u865f\u50b3\u5c0e\u7684\u9014\u5f91\u3002ROR1\u5728\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u548c\u591a\u7a2e\u5be6\u9ad4\u7624\u4e2d\u9ad8\u983b\u904e\u8868\u9054\uff0c\u800c\u5728\u6b63\u5e38\u7d44\u7e54\u4e2d\u8868\u9054\u8f03\u4f4e\u6216\u7f3a\u5931\uff0c\u4f7f\u5f97ROR1\u6210\u70ba\u4e00\u500b\u6709\u5438\u5f15\u529b\u7684\u816b\u7624\u6cbb\u7642\u9776\u9ede\u3002CS5001\u662f\u76ee\u524d\u5df2\u77e5\u9996\u500b\u5728\u5be6\u9ad4\u7624\u548c\u6dcb\u5df4\u7624\u4e2d\u5747\u89c0\u5bdf\u5230\u81e8\u5e8a\u7642\u6548\u7684ROR1 ADC\u3002<\/p>\n

\u57fa\u77f3\u85e5\u696d\u9996\u5e2d\u57f7\u884c\u5b98\u3001\u7814\u767c\u7e3d\u88c1\u3001\u57f7\u884c\u8463\u4e8b\u694a\u5efa\u65b0\u535a\u58eb\u8868\u793a\uff1a\u300c\u975e\u5e38\u9ad8\u8208\u6211\u5011\u7684ROR1 ADC\u5728\u81e8\u5e8a\u4e0a\u6301\u7e8c\u986f\u793a\u826f\u597d\u7684\u6297\u816b\u7624\u6d3b\u6027\u53ca\u5b89\u5168\u6027\uff0c\u672c\u6b21ASH\u516c\u4f48\u4e86CS5001\u5728\u66f4\u591a\u665a\u671f\u6dcb\u5df4\u7624\u60a3\u8005\u4e2d\u7684\u55ae\u85e5\u81e8\u5e8a\u6578\u64da\uff0c\u9019\u4e9b\u60a3\u8005\u7d55\u5927\u90e8\u5206\u5df2\u7d93\u7d93\u6b773\u7dda\u6cbb\u7642\u5931\u6557\u3002\u6211\u5011\u5728\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u8207\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u4e2d\u5747\u80fd\u89c0\u5bdf\u5230CS5001\u4ee4\u4eba\u9f13\u821e\u7684\u6297\u816b\u7624\u6d3b\u6027\uff0c\u7279\u5225\u5728\u7b2c8\u5291\u91cf\u6c34\u5e73\uff08125 \u03bcg\/kg\uff0913\u4f8b\u53ef\u8a55\u4f30\u7684\u665a\u671fB\u7d30\u80de\u6dcb\u5df4\u7624\u60a3\u8005\u4e2d\uff0cORR\u66f4\u662f\u9054\u5230\u4e8676.9%\uff0c\u6211\u5011\u4e5f\u6703\u5728\u5373\u5c07\u958b\u555f\u76841b\u671f\u7814\u7a76\u4e2d\u9032\u4e00\u6b65\u8a55\u4f30\u548c\u512a\u5316\u8a72\u5291\u91cf\u3002\u7531\u65bcCS5001\u5728\u4fb5\u8972\u6027\u548c\u60f0\u6027\u6dcb\u5df4\u7624\u4e2d\u5747\u5df2\u5c55\u73fe\u521d\u6b65\u7642\u6548\uff0c\u6211\u5011\u66f4\u52a0\u5805\u4fe1CS5001\u5177\u6709\u5ee3\u95ca\u7684\u81e8\u5e8a\u958b\u767c\u524d\u666f\u548c\u6975\u5927\u7684\u5e02\u5834\u7af6\u722d\u529b\u3002\u6211\u5011\u5c07\u52a0\u5feb\u63a8\u9032CS5001\u7684\u958b\u767c\u9032\u7a0b\uff0c\u5e0c\u671b\u65e9\u65e5\u80fd\u70ba\u6dcb\u5df4\u7624\u60a3\u8005\u5e36\u4f86\u5168\u65b0\u7684\u6cbb\u7642\u9078\u64c7\u3002\u300d<\/p>\n

\u60a3\u8005\u57fa\u7dda <\/p>\n

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\u5b89\u5168\u6027\u6578\u64da <\/p>\n

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\u6709\u6548\u6027\u6578\u64da <\/p>\n

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\u5c0d\u65bcHL\uff0c\u5f9e\u8d77\u6548\u5291\u91cfDL5\uff0850 \u03bcg\/kg\uff09\u8d77\u81f3DL9\uff08156\u03bcg\/kg\uff09\u768410\u4f8b\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0cORR\u905460.0%\uff0c\u5176\u4e2d\u5305\u62ec3\u4f8b\u5b8c\u5168\u7de9\u89e3\uff08CR\uff09\u548c3\u4f8b\u90e8\u5206\u7de9\u89e3\uff08PR\uff09\u3002DL8\uff08125 \u03bcg\/kg\uff09\u76843\u4f8b\u53ef\u8a55\u4f30\u60a3\u8005\u5747\u9054\u5230\u4e86\u5ba2\u89c0\u7de9\u89e3\uff0c\u53732\u4f8bCR\u548c1\u4f8bPR\u3002<\/p>\n

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\u96fb\u8a71\u6703\u8b70\u548c\u7db2\u7d61\u76f4\u64ad<\/p>\n

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\u95dc\u65bcCS5001 \uff08ROR1 ADC\uff09<\/p>\n

CS5001\u662f\u4e00\u6b3e\u4ee5\u53d7\u9ad4\u916a\u6c28\u9178\u6fc0\u9176\u6a23\u5b64\u5152\u53d7\u9ad41\uff08receptor tyrosine kinase-like orphan receptor 1, ROR1\uff09\u70ba\u9776\u9ede\u7684\u6297\u9ad4\u5076\u806f\u85e5\u7269\uff08ADC\uff09\u3002CS5001\u5177\u6709\u7368\u7279\u7684\u8a2d\u8a08\uff0c\u4f7f\u7528\u816b\u7624\u7279\u7570\u6fc0\u6d3b\u7684\u5421\u54af\u4e26\u82ef\u4e8c\u6c2e\u5353\uff08pyrrolobenzodiazepine, PBD\uff09\u524d\u6bd2\u7d20\u8f09\u8377\uff08Payload\uff09\u548c\u9023\u63a5\u5b50(linker)\u3002CS5001\u53ea\u5728\u5230\u9054\u816b\u7624\u5f8c\uff0c\u88ab\u816b\u7624\u7d30\u80de\u5167\u541e\u5f8c\uff0c\u5728\u6eb6\u9176\u9ad4\u4e2d\u5176\u9023\u63a5\u5b50\u88ab\u5728\u816b\u7624\u7d30\u80de\u4e2d\u9ad8\u8868\u9054\u7684\u7279\u7570\u6027\u9176\u5207\u5272\u91cb\u653ePBD\u524d\u6bd2\u7d20\uff0c\u7e7c\u800cPBD\u524d\u6bd2\u7d20\u5728\u816b\u7624\u7d30\u80de\u5167\u88ab\u6fc0\u6d3b\uff0c\u5f9e\u800c\u6bba\u6b7b\u816b\u7624\u7d30\u80de\u3002\u9019\u7a2e\u9023\u63a5\u5b50\u52a0\u524d\u6bd2\u7d20\u7684\u300c\u96d9\u63a7\u300d\u6a5f\u5236\u6709\u6548\u5730\u6e1b\u5c11\u8207\u50b3\u7d71PBD\u8f09\u8377\u6709\u95dc\u7684\u6bd2\u6027\u554f\u984c\uff0c\u800c\u7372\u5f97\u66f4\u5927\u7684\u5b89\u5168\u7a97\u53e3\u3002CS5001\u5df2\u5728\u5e7e\u7a2e\u81e8\u5e8a\u524d\u764c\u75c7\u6a21\u578b\u4e2d\u8b49\u660e\u5177\u6709\u5b8c\u5168\u7684\u816b\u7624\u6291\u88fd\u4f5c\u7528\uff0c\u4e26\u5c55\u793a\u51fa\u826f\u597d\u7684\u8840\u6e05\u534a\u8870\u671f\u53ca\u85e5\u4ee3\u52d5\u529b\u5b78\u7279\u5fb5\u3002\u9019\u4e9b\u90fd\u8868\u660eCS5001\u5728\u591a\u7a2e\u5be6\u9ad4\u7624\u548c\u8840\u6db2\u7624\u4e2d\u64c1\u6709\u5de8\u5927\u7684\u81e8\u5e8a\u958b\u767c\u6f5b\u529b\u548c\u5ee3\u6cdb\u7684\u61c9\u7528\u524d\u666f\u3002\u6b64\u5916\uff0cCS5001\u5229\u7528\u5b9a\u5411\u5076\u806f\u6280\u8853\u7372\u5f97\u7cbe\u6e96\u7684\u85e5\u7269\u6297\u9ad4\u6bd4\u7387\uff08DAR\uff09\uff0c\u4fbf\u65bc\u5be6\u73fe\u5747\u8cea\u751f\u7522\u53ca\u5927\u898f\u6a21\u751f\u7522\u3002<\/p>\n

2020\u5e7410\u6708\uff0c\u57fa\u77f3\u85e5\u696d\u8207LigaChem Biosciences, Inc.\uff08LCB\uff09\u5c31CS5001\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u9054\u6210\u6388\u6b0a\u5354\u8b70\u3002CS5001\u6700\u521d\u662f\u7531\u97d3\u570b\u9818\u5148\u7684\u751f\u7269\u79d1\u6280\u516c\u53f8LCB\u548cABL bio\u5171\u540c\u5408\u6210\u3002\u6839\u64da\u5354\u8b70\u689d\u6b3e\uff0c\u57fa\u77f3\u85e5\u696d\u7372\u5f97CS5001\u5728\u97d3\u570b\u4ee5\u5916\u7684\u5168\u7403\u5176\u4ed6\u5730\u5340\u7684\u7368\u5bb6\u958b\u767c\u548c\u5546\u696d\u5316\u6b0a\u5229\u3002<\/p>\n

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\u95dc\u65bc\u57fa\u77f3\u85e5\u696d<\/p>\n

\u57fa\u77f3\u85e5\u696d\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc: 2616\uff09\u6210\u7acb\u65bc2015\u5e74\u5e95\uff0c\u662f\u4e00\u5bb6\u5c08\u6ce8\u65bc\u6297\u816b\u7624\u85e5\u7269\u7814\u767c\u7684\u5275\u65b0\u9a45\u52d5\u578b\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u6eff\u8db3\u4e2d\u570b\u548c\u5168\u7403\u764c\u75c7\u60a3\u8005\u7684\u6bb7\u5207\u91ab\u7642\u9700\u6c42\u3002\u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f8\u5df2\u6210\u529f\u4e0a\u5e024\u6b3e\u5275\u65b0\u85e5\u3001\u7372\u627916\u9805\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\uff08NDA\uff09\u4ee5\u53ca9\u9805\u9069\u61c9\u75c7\u3002\u7576\u524d\u7814\u767c\u7ba1\u7dda\u5747\u8861\u914d\u7f6e\u4e86\u6f5b\u5728\u540c\u985e\u9996\u5275\u6216\u540c\u985e\u6700\u4f73\u7684\u6297\u9ad4\u5076\u806f\u85e5\u7269\uff08ADC\uff09\u3001\u591a\u7279\u7570\u6027\u6297\u9ad4\u3001\u4ee5\u53ca\u514d\u75ab\u7642\u6cd5\u548c\u7cbe\u6e96\u6cbb\u7642\u85e5\u7269\u5728\u5167\u768418\u6b3e\u5019\u9078\u85e5\u7269\u3002\u540c\u6642\uff0c\u57fa\u77f3\u85e5\u696d\u64c1\u6709\u4e00\u652f\u8cc7\u6df1\u7ba1\u7406\u5718\u968a\uff0c\u300c\u5168\u93c8\u689d\u300d\u8986\u84cb\u81e8\u5e8a\u524d\u63a2\u7d22\u3001\u81e8\u5e8a\u8f49\u5316\u3001\u81e8\u5e8a\u958b\u767c\u3001\u85e5\u7269\u751f\u7522\u3001\u5546\u52d9\u62d3\u5c55\u3001\u5546\u696d\u904b\u71df\u7b49\u95dc\u9375\u74b0\u7bc0\u3002<\/p>\n

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