{"id":23350,"date":"2024-11-25T00:31:00","date_gmt":"2024-11-24T16:31:00","guid":{"rendered":"https:\/\/www.franchise.com.hk\/%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%b0%87%e5%9c%a8esmo-asia-2024%e5%b9%b4%e6%9c%83%e4%b8%8a%e5%85%ac%e5%b8%83ibi343%ef%bc%88cldn18-2-adc%ef%bc%89%e7%ad%89%e5%a4%9a%e9%a0%85%e5%89%b5%e6%96%b0\/23350"},"modified":"2024-11-25T00:31:00","modified_gmt":"2024-11-24T16:31:00","slug":"%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%b0%87%e5%9c%a8esmo-asia-2024%e5%b9%b4%e6%9c%83%e4%b8%8a%e5%85%ac%e5%b8%83ibi343%ef%bc%88cldn18-2-adc%ef%bc%89%e7%ad%89%e5%a4%9a%e9%a0%85%e5%89%b5%e6%96%b0","status":"publish","type":"post","link":"https:\/\/www.franchise.com.hk\/zh-hans\/%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%b0%87%e5%9c%a8esmo-asia-2024%e5%b9%b4%e6%9c%83%e4%b8%8a%e5%85%ac%e5%b8%83ibi343%ef%bc%88cldn18-2-adc%ef%bc%89%e7%ad%89%e5%a4%9a%e9%a0%85%e5%89%b5%e6%96%b0\/23350","title":{"rendered":"\u4fe1\u9054\u751f\u7269\u5c07\u5728ESMO Asia 2024\u5e74\u6703\u4e0a\u516c\u5e03IBI343\uff08CLDN18.2 ADC\uff09\u7b49\u591a\u9805\u5275\u65b0\u7ba1\u7dda\u66f4\u65b0\u81e8\u5e8a\u6578\u64da"},"content":{"rendered":"<p><span class=\"legendSpanClass\">\u7f8e\u570b\u820a\u91d1\u5c71\u548c\u4e2d\u570b\u8607\u5dde<\/span><span class=\"legendSpanClass\">2024\u5e7411\u670825\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u4fe1\u9054\u751f\u7269\u5236\u85e5\u96c6\u5718\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u80a1\u7968\u4ee3\u78bc\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u53ca\u5fc3\u8840\u7ba1\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u5275\u65b0\u85e5\u7269\u7684\u751f\u7269\u5236\u85e5\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u5e03\uff0c\u5c07\u57282024\u5e74\u6b50\u6d32\u816b\u7624\u5167\u79d1\u5b78\u6703\u4e9e\u6d32\u5e74\u6703\uff08ESMO Asia\uff09\u4e0a\u516c\u5e03\u8fd110\u9805\u81e8\u5e8a\u6578\u64da\uff0c\u542b2\u9805\u53e3\u982d\u5831\u544a\uff0c\u5176\u4e2d\u5305\u62ecIBI343\uff08\u5275\u65b0TOPO1i CLDN18.2 ADC\uff09\u6cbb\u7642\u80f0\u817a\u764c\u7684I\u671f\u66f4\u65b0\u6578\u64da\u3002ESMO Asia\u5e74\u6703\u5c07\u65bc\u7576\u5730\u6642\u95932024\u5e7412\u67086\u65e5-8\u65e5\u5728\u65b0\u52a0\u5761\u8209\u8fa6\u3002<\/p>\n<p>\u8a73\u7d30\u6458\u8981\u4fe1\u606f\u5982\u4e0b\uff1a<\/p>\n<p>\u53e3\u982d\u5831\u544a<\/p>\n<p>\u6458\u8981\u6a19\u984c\uff1a\u6297Claudin18.2 (CLDN18.2) ADC\u85e5\u7269IBI343\u6cbb\u7642\u665a\u671f\u80f0\u817a\u5c0e\u7ba1\u817a\u764c (PDAC): I\u671f\u7814\u7a76\u6578\u64da\u66f4\u65b0<br \/>\u6458\u8981\u7de8\u865f:\u00a0132MO<br \/>\u5c55\u793a\u5f62\u5f0f\uff1aMini Oral<br \/>\u5c55\u793a\u6642\u9593\uff1a2024\u5e7412\u67087\u65e5, 09:50-09:55<br \/>\u8b1b\u8005\uff1a\u5f35\u528d\u00a0\u6559\u6388\uff0c\u5fa9\u65e6\u5927\u5b78\u9644\u5c6c\u816b\u7624\u91ab\u9662\u00a0<\/p>\n<p>\u6458\u8981\u6a19\u984c\uff1amFOLFOX6+\u8c9d\u4f10\u73e0\u55ae\u6297+\u4fe1\u8fea\u5229\u55ae\u6297 (PD-1\u6297\u9ad4) \u6cbb\u7642\u5c40\u90e8\u665a\u671fMSS\u578b\u7d50\u76f4\u8178\u764c\uff1a\u4e00\u9805\u524d\u77bb\u6027\u3001\u55ae\u81c2\u3001\u958b\u653e\u6a19\u7c3dII\u671f\u7814\u7a76\uff08BASKET II\uff09<br \/>\u6458\u8981\u7de8\u865f\uff1a74MO<br \/>\u5c55\u793a\u5f62\u5f0f\uff1aMini Oral<br \/>\u5c55\u793a\u6642\u9593\uff1a2024\u5e7412\u67087\u65e5, 10:20-10:25 \u00a0<br \/>\u8b1b\u8005\uff1a\u9ec3\u4fca\u00a0\u6559\u6388\uff0c\u00a0\u4e2d\u5c71\u5927\u5b78\u9644\u5c6c\u7b2c\u516d\u91ab\u9662\u00a0<\/p>\n<p>\u58c1\u5831\u5c55\u793a<\/p>\n<p>\u6458\u8981\u6a19\u984c\uff1a\u00a0\u4fe1\u8fea\u5229\u55ae\u6297\u806f\u5408\u5b89\u7f85\u66ff\u5c3c\u4e00\u7dda\u6cbb\u7642\u665a\u671f\u8178\u764c\u00a0(APICAL-CRC)\uff1a\u4e00\u9805\u958b\u653e\u6a19\u7c3d\u3001\u55ae\u81c2\u3001II\u671f\u7814\u7a76<br \/>\u6458\u8981\u7de8\u865f:\u00a075P<br \/>\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831<br \/>\u5c55\u793a\u6642\u9593\uff1a2024\u5e7412\u67087\u65e5, 17:50-18:45<br \/>\u8b1b\u8005\uff1a\u738b\u6e5b\u00a0\u6559\u6388\uff0c\u4e0a\u6d77\u9577\u5f81\u91ab\u9662\u00a0<\/p>\n<p>\u6458\u8981\u6a19\u984c\uff1a\u809d\u52d5\u8108\u704c\u6ce8\u5316\u7642\uff08HAIC\uff09\u806f\u5408\u4fe1\u8fea\u5229\u55ae\u6297\u548c\u591a\u7d0d\u975e\u5c3c\u4f5c\u70ba\u4e0d\u53ef\u5207\u9664\u809d\u5167\u81bd\u7ba1\u764c\u4e00\u7dda\u6cbb\u7642\u7684\u4e00\u9805\u55ae\u81c2\u3001\u591a\u4e2d\u5fc3\u3001II\u671f\u7814\u7a76\uff08CHANCE 2203\uff09<br \/>\u6458\u8981\u7de8\u865f\uff1a137P<br \/>\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831<br \/>\u5c55\u793a\u6642\u9593\uff1a2024\u5e7412\u67087\u65e5, 17:50-18:45<br \/>\u8b1b\u8005\uff1a\u6ed5\u768b\u8ecd\u00a0\u6559\u6388\uff0c\u6771\u5357\u5927\u5b78\u9644\u5c6c\u4e2d\u5927\u91ab\u9662\u00a0<\/p>\n<p>\u6458\u8981\u6a19\u984c\uff1aFOLFOX-HAIC\u806f\u5408\u4fe1\u8fea\u5229\u55ae\u6297\u53ca\u8c9d\u4f10\u73e0\u55ae\u6297\u6cbb\u7642\u665a\u671f\u809d\u7d30\u80de\u764c\uff1a\u4e00\u9805\u55ae\u81c2II\u671f\u7814\u7a76<br 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\/>\u8b1b\u8005\uff1a\u5f35\u6d77\u658c\u00a0\u6559\u6388\uff0c\u4e0a\u6d77\u6771\u65b9\u809d\u81bd\u5916\u79d1\u91ab\u9662\u00a0<\/p>\n<p>\u4e2d\u6587\u6a19\u984c:\u00a0\u4fe1\u8fea\u5229\u55ae\u6297\u806f\u5408\u5b89\u7f85\u66ff\u5c3cvs. \u514d\u75ab\u806f\u5408\u5316\u7642\u6cbb\u7642\u570d\u624b\u8853\u671fNSCLC\uff1aII\u671f\u81e8\u5e8a\u7814\u7a76<br \/>\u6458\u8981\u7de8\u865f\uff1a599P<br \/>\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831<br \/>\u5c55\u793a\u6642\u9593\uff1a2024\u5e7412\u67087\u65e5, 17:50-18:45<br 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\/>\u8b1b\u8005\uff1a\u5f90\u745e\u83ef\u00a0\u6559\u6388\uff0c\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\u00a0<\/p>\n<p>\u6458\u8981\u6a19\u984c:\u00a0\u4fe1\u8fea\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u53ca\u51b7\u51cd\u6d88\u878d\u4e00\u7dda\u6cbb\u7642\u665a\u671f\u975e\u9c57\u72c0\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7684\u7642\u6548\u548c\u5b89\u5168\u6027<br \/>\u6458\u8981\u7de8\u865f\uff1a722TiP<br \/>\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831<br \/>\u5c55\u793a\u6642\u9593\uff1a2024\u5e7412\u67087\u65e5, 17:50-18:45<br \/>\u8b1b\u8005\uff1a\u9ad8\u5fd7\u5f37 \u6559\u6388\uff0c\u4e0a\u6d77\u4ea4\u901a\u5927\u5b78\u9644\u5c6c\u80f8\u79d1\u91ab\u9662\u00a0<\/p>\n<p>\u4fe1\u9054\u751f\u7269\u5236\u85e5\u96c6\u5718\u9ad8\u7d1a\u526f\u7e3d\u88c1\u5468\u8f1d\u535a\u58eb\u8868\u793a\uff1a\u300c\u5f88\u9ad8\u8208\u5728\u672c\u6b21ESMO Asia\u5927\u6703\u4e0a\u6301\u7e8c\u66f4\u65b0\u6211\u5011\u591a\u500b\u7a81\u7834\u6027\u81e8\u5e8a\u6578\u64da\uff0c\u5c24\u5176\u5728\u5168\u7403\u96e3\u6cbb\u764c\u7a2e\u80f0\u817a\u764c\u4e0a\uff0c\u4fe1\u9054\u751f\u7269\u5275\u65b0TOPO1i CLDN18.2 ADC IBI343\uff0c\u5728\u65e9\u671f\u5c11\u91cf\u4eba\u7fa4\u521d\u6b65\u7642\u6548\u4fe1\u865f\u7684\u57fa\u790e\u4e0a\uff0c\u64f4\u5927\u5165\u7d44\u5f8c\u4f9d\u7136\u770b\u5230\u4e86\u4ee4\u4eba\u9f13\u821e\u7684\u7642\u6548\u4fe1\u865f\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u3002IBI343\u4ee5\u5176\u7368\u7279\u7684\u6297\u9ad4\u7aefFc\u6c89\u9ed8\u8a2d\u8a08\uff0c\u7a69\u5b9a\u7684linker\uff0c\u5f37\u6d3b\u6027extecan\u7684payload\uff0c\u6210\u70ba\u76ee\u524d\u5728PDAC\u6cbb\u7642\u65b9\u9762\u9032\u5ea6\u6700\u70ba\u9818\u5148\u7684CLDN18.2 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Anderson 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