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Pointeau\u8868\u793a\uff0c\u300c\u8f1d\u745e\u5728\u6297\u611f\u67d3\u9818\u57df\u6df1\u8015\u591a\u5e74\u3002\u6211\u5011\u59cb\u7d42\u81f4\u529b\u65bc\u300e\u70ba\u60a3\u8005\u5e36\u4f86\u6539\u8b8a\u5176\u751f\u6d3b\u7684\u7a81\u7834\u5275\u65b0\u300f\uff0c\u4ee5\u61c9\u5c0d\u7d30\u83cc\u3001\u771f\u83cc\u3001\u75c5\u6bd2\u7b49\u591a\u7a2e\u5fae\u751f\u7269\u611f\u67d3\u7684\u6311\u6230\uff0c\u6e1b\u5c11\u60a3\u8005\u75be\u75c5\u8ca0\u64d4\u3002\u6b64\u6b21\u8207\u518d\u9f0e\u91ab\u85e5\u7684\u5408\u4f5c\uff0c\u96d9\u65b9\u5c07\u651c\u624b\u5c0d\u6297\u9b91\u66fc\u4e0d\u52d5\u687f\u83cc\u6cbb\u7642\u4e2d\u65e5\u76ca\u56b4\u91cd\u7684\u8010\u85e5\u554f\u984c\uff0c\u76e1\u5feb\u6eff\u8db3\u60a3\u8005\u672a\u88ab\u6eff\u8db3\u7684\u81e8\u5e8a\u6cbb\u7642\u9700\u6c42\uff0c\u9ad4\u73fe\u91ab\u85e5\u4f01\u696d\u7684\u65b0\u8cea\u751f\u7522\u529b\uff0c\u52a9\u529b&#8217;\u5065\u5eb7\u4e2d\u570b&#8217;\u76ee\u6a19\u7684\u5be6\u73fe\u3002\u300d<\/p>\n<p>\u95dc\u65bc\u9f0e\u512a\u6a02\u00ae\uff08\u8212\u5df4\u5766\u9209-\u5ea6\u6d1b\u5df4\u5766\u9209\uff09<\/p>\n<p>\u975c\u8108\u8f38\u6ce8\u578b\u7d44\u5408\u85e5\u7269\u9f0e\u512a\u6a02\u00ae\uff08\u8212\u5df4\u5766\u9209-\u5ea6\u6d1b\u5df4\u5766\u9209\uff09\u7531Entasis Therapeutics Inc.\uff08Innoviva Specialty Therapeutics\u5b50\u516c\u53f8\uff09\u958b\u767c\uff0c\u662f\u7531\u8212\u5df4\u5766\u9209\uff08\u4e00\u7a2e\u03b2-\u5167\u9170\u80fa\u985e\u6297\u751f\u7d20\uff09\u548c\u5ea6\u6d1b\u5df4\u5766\u9209\uff08\u4e00\u7a2e\u03b2-\u5167\u9170\u80fa\u9176\u6291\u5236\u5291\uff09\u7d44\u5408\u800c\u6210\u3002\u8212\u5df4\u5766\u9209-\u5ea6\u6d1b\u5df4\u5766\u9209\u65bc2023\u5e74\u30012024\u5e74\u5206\u5225\u7531\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u548c\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u6279\u51c6\uff0c\u7528\u65bc\u6cbb\u7642\u7531\u9b91\u66fc-\u918b\u9178\u9223\u4e0d\u52d5\u687f\u83cc\u5fa9\u5408\u9ad4\u654f\u611f\u5206\u96e2\u682a\u5f15\u8d77\u768418\u6b72\u53ca\u4ee5\u4e0a\u60a3\u8005\u7684\u91ab\u9662\u7372\u5f97\u6027\u7d30\u83cc\u6027\u80ba\u708e\u548c\u547c\u5438\u6a5f\u76f8\u95dc\u6027\u7d30\u83cc\u6027\u80ba\u708e\uff08HABP\/VABP\uff09\u3002<\/p>\n<p>\u8212\u5df4\u5766\u9209-\u5ea6\u6d1b\u5df4\u5766\u9209\u5728\u4e2d\u570b\u7372\u6279\u662f\u57fa\u65bcATTACK\u7814\u7a76\uff08NCT03894046\uff09\u7684\u7a4d\u6975\u7d50\u679c\uff0c\u8a72\u7814\u7a76\u662f\u4e00\u9805\u5168\u74033\u671f\u6ce8\u518a\u6027\u7814\u7a76\uff0c\u8a55\u4f30\u4e86\u8212\u5df4\u5766\u9209-\u5ea6\u6d1b\u5df4\u5766\u9209v.s.\u591a\u7c98\u83cc\u7d20E\u7528\u65bc\u6cbb\u7642\u9b91\u66fc\u4e0d\u52d5\u687f\u83cc\u611f\u67d3\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u5728\u8a72\u7814\u7a76\u4e2d\uff0c\u8212\u5df4\u5766\u9209-\u5ea6\u6d1b\u5df4\u5766\u9209\u5728\u7814\u7a76\u4e3b\u8981\u7d42\u9ede\uff0c\u5373\u78b3\u9752\u9709\u70ef\u985e\u8010\u85e5\u4e0d\u52d5\u687f\u83cc\u611f\u67d3\u60a3\u8005\u768428\u5929\u5168\u56e0\u6b7b\u4ea1\u7387\u65b9\u9762\uff0c\u8207\u591a\u7c98\u83cc\u7d20E\u76f8\u6bd4\u5177\u6709\u7d71\u8a08\u5b78\u4e0a\u7684\u975e\u52a3\u6548\u6027\uff0c\u4e26\u4e14\u5728\u81e8\u5e8a\u6cbb\u6108\u7387\u65b9\u9762\u6709\u986f\u8457\u63d0\u5347\u3002\u8212\u5df4\u5766\u9209-\u5ea6\u6d1b\u5df4\u5766\u9209\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u4e26\u5728\u6574\u500b\u81e8\u5e8a\u7814\u7a76\u9805\u76ee\u4e2d\u5747\u8868\u73fe\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u7279\u5f81\u3002\u518d\u9f0e\u91ab\u85e5\u53c3\u8207\u4e86ATTACK\u5168\u7403\u7814\u7a76\uff0c\u5728\u4e2d\u570b\u62db\u52df\u60a3\u8005\u3002\u4e2d\u570b\u60a3\u8005\u968a\u5217\u6578\u64da\u8b49\u5be6\u4e86\u5168\u7403\u7814\u7a76\u4e2d\u95dc\u65bc\u6b7b\u4ea1\u7387\u548c\u81e8\u5e8a\u61c9\u7b54\u6539\u5584\u7684\u7d50\u679c\u3002<\/p>\n<p>\u518d\u9f0e\u91ab\u85e5\u7531Entasis Therapeutics 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href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.sec.gov%2F&amp;esheet=54124369&amp;newsitemid=20240918153321&amp;lan=en-US&amp;anchor=www.sec.gov&amp;index=19&amp;md5=40c4bea2811c9f5e2ef2350512a454de\" target=\"_blank\" rel=\"noopener\">www.sec.gov<\/a>\u00a0\u548c<a href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.pfizer.com&amp;esheet=54124369&amp;newsitemid=20240918153321&amp;lan=en-US&amp;anchor=www.pfizer.com&amp;index=20&amp;md5=e9cf47119afb36069970da15e4586770\" target=\"_blank\" rel=\"noopener\">www.pfizer.com<\/a>\u67e5\u95b1\u3002<\/p>\n<p>\u53c3\u8003\u6587\u737b:<\/p>\n<p>(1)\u00a0 El-Ghali A, Kunz Coyne AJ, Caniff K, Bleick C, Rybak MJ. Sulbactam-durlobactam: A novel \u03b2-lactam-\u03b2-lactamase inhibitor combination targeting carbapenem-resistant Acinetobacter baumannii infections. Pharmacotherapy. 2023;43(6):502-513. doi:10.1002\/phar.2802<br \/>(2)\u00a0 Centers for Disease Control and Prevention, &#8220;Carbapenem-resistant Acinetobacter baumannii (CRAB): An urgent public health threat in\u00a0United States\u00a0healthcare facilities,&#8221;\u00a0August 2021:\u00a0<a href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Farpsp.cdc.gov%2Fstory%2Fcra-urgent-public-health-threat&amp;esheet=54002027&amp;newsitemid=20240519020622&amp;lan=en-US&amp;anchor=https%3A%2F%2Farpsp.cdc.gov%2Fstory%2Fcra-urgent-public-health-threat&amp;index=10&amp;md5=eb83e17938b29ae03797ac1128ed51f5\" target=\"_blank\" rel=\"noopener\">https:\/\/arpsp.cdc.gov\/story\/cra-urgent-public-health-threat<\/a><br \/>(3)\u00a0 Antimicrobial Resistance Collaborators. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis.\u00a0Lancet. 2022; 399(10325):629-655.\u00a0<a href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.thelancet.com%2Fjournals%2Flancet%2Farticle%2FPIIS0140-6736%252821%252902724-0%2Ffulltext&amp;esheet=54002027&amp;newsitemid=20240519020622&amp;lan=en-US&amp;anchor=https%3A%2F%2Fwww.thelancet.com%2Fjournals%2Flancet%2Farticle%2FPIIS0140-6736%2821%2902724-0%2Ffulltext&amp;index=11&amp;md5=445cacbb1ff510ca1ce2069b021e1eb1\" target=\"_blank\" rel=\"noopener\">https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(21)02724-0\/fulltext<\/a><br \/>(4)\u00a0 WHO Bacterial Priority Pathogens List, 2024<br \/>(5)\u00a0 Zhang C, Fu X, Liu Y, Zhao H, <span class=\"xn-person\">Wang G. Burden<\/span> of infectious diseases and bacterial antimicrobial resistance in <span class=\"xn-location\">China<\/span>: a systematic analysis for the global burden of disease study 2019. Lancet Reg Health West Pac. 2023;43:100972. Published 2023 Nov 22. doi:10.1016\/j.lanwpc.2023.100972<br \/>(6)\u00a0 2022 Annual Report of China Antimicrobial Resistance Surveillance System (CARSS)<br \/>(7)\u00a0 Zhang S, Di L, Qi Y, Qian X, Wang S. Treatment of infections caused by carbapenem-resistant\u00a0Acinetobacter baumannii.\u00a0Front Cell Infect Microbiol. 2024;14:1395260. Published 2024 Jul 18. doi:10.3389\/fcimb.2024.1395260<br \/>(8)\u00a0 2023 Annual Report of China Antimicrobial Surveillance Network (CHINET)<\/p>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>","protected":false},"excerpt":{"rendered":"<p>\u4e2d\u570b\u4e0a\u6d77\u548c\u7f8e\u570b\u99ac\u85a9\u8af8\u585e\u5dde\u528d\u6a4b2024\u5e7411\u670821\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u518d\u9f0e\u91ab\u85e5\uff08\u4ee5\u4e0b\u7c21\u7a31\u300c\u518d\u9f0e\u91ab\u85e5\u300d\uff0c\u7d0d\u65af\u9054\u514b\u80a1\u7968\u4ee3\u78bc\uff1aZLAB\uff1b\u9999\u6e2f\u806f\u4ea4\u6240\u80a1\u4efd\u4ee3\u865f\uff1a9688 \uff09\u548c\u8f1d\u745e\uff08\u4ee5\u4e0b\u7c21\u7a31\u300c\u8f1d\u745e\u300d\uff0cNYSE: PFE\uff09\u4eca\u65e5\u5ba3\u5e03\uff0c\u96d9\u65b9\u5c31\u65b0\u578b\u6297\u83cc\u85e5\u7269\u9f0e\u512a\u6a02\u00ae\uff08\u8212\u5df4\u5766\u9209-\u5ea6\u6d1b\u5df4\u5766\u9209\uff09\u9054\u6210\u5728\u4e2d\u570b\u5167\u5730\u7684\u6230\u7565\u5408\u4f5c\uff0c\u7531\u8f1d\u745e\u65d7\u4e0b\u516c\u53f8\u7368\u5bb6\u8ca0\u8cac\u8a72\u7522\u54c1\u5728\u4e2d\u570b\u5167\u5730\u7684\u76f8\u95dc\u5546\u696d\u5316\u904b\u71df\u3002\u901a\u904e\u6b64\u6b21\u5408\u4f5c\uff0c\u518d\u9f0e\u91ab\u85e5\u5c07\u501f\u52a9\u8f1d\u745e\u65d7\u4e0b\u516c\u53f8\u5728\u6297\u611f\u67d3\u9818\u57df\u884c\u696d\u9818\u5148\u7684\u5546\u696d\u5316\u80fd\u529b\u4ee5\u52a9\u529b\u4e2d\u570b\u6709\u9700\u8981\u7684\u60a3\u8005\u80fd\u5920\u66f4\u5feb\u7372\u5f97\u9019\u4e00\u91cd\u8981\u7642\u6cd5\u3002\u96d9\u65b9\u95dc\u65bc\u8a72\u9032\u53e3\u7522\u54c1\u7684 &#8230; <\/p>\n<p class=\"read-more-container\"><a title=\"\u518d\u9f0e\u91ab\u85e5\u8207\u8f1d\u745e\u5c31\u65b0\u578b\u6297\u83cc\u85e5\u7269\u9f0e\u512a\u6a02\u00ae (\u8212\u5df4\u5766\u9209-\u5ea6\u6d1b\u5df4\u5766\u9209\uff09\u9054\u6210\u6230\u7565\u5408\u4f5c\" class=\"read-more button\" href=\"https:\/\/www.franchise.com.hk\/zh-hans\/%e5%86%8d%e9%bc%8e%e9%86%ab%e8%97%a5%e8%88%87%e8%bc%9d%e7%91%9e%e5%b0%b1%e6%96%b0%e5%9e%8b%e6%8a%97%e8%8f%8c%e8%97%a5%e7%89%a9%e9%bc%8e%e5%84%aa%e6%a8%82-%e8%88%92%e5%b7%b4%e5%9d%a6%e9%88%89\/23322#more-23322\" aria-label=\"\u66f4\u591a \u518d\u9f0e\u91ab\u85e5\u8207\u8f1d\u745e\u5c31\u65b0\u578b\u6297\u83cc\u85e5\u7269\u9f0e\u512a\u6a02\u00ae (\u8212\u5df4\u5766\u9209-\u5ea6\u6d1b\u5df4\u5766\u9209\uff09\u9054\u6210\u6230\u7565\u5408\u4f5c\">\u4e86\u89e3\u8a73\u60c5<\/a><\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_generate-full-width-content":"","spay_email":"","footnotes":""},"categories":[1],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.4 - 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