{"id":23263,"date":"2024-11-19T11:30:00","date_gmt":"2024-11-19T03:30:00","guid":{"rendered":"https:\/\/www.franchise.com.hk\/%e9%a8%b0%e7%9b%9b%e5%8d%9a%e8%97%a5%e9%a6%96%e6%ac%a1%e5%9c%a82024%e5%b9%b4%e7%be%8e%e5%9c%8b%e8%82%9d%e7%97%85%e7%a0%94%e7%a9%b6%e5%ad%b8%e6%9c%83-aasld-%e5%b9%b4%e6%9c%83%e4%b8%8a%e7%99%bc\/23263"},"modified":"2024-11-19T11:30:00","modified_gmt":"2024-11-19T03:30:00","slug":"%e9%a8%b0%e7%9b%9b%e5%8d%9a%e8%97%a5%e9%a6%96%e6%ac%a1%e5%9c%a82024%e5%b9%b4%e7%be%8e%e5%9c%8b%e8%82%9d%e7%97%85%e7%a0%94%e7%a9%b6%e5%ad%b8%e6%9c%83-aasld-%e5%b9%b4%e6%9c%83%e4%b8%8a%e7%99%bc","status":"publish","type":"post","link":"https:\/\/www.franchise.com.hk\/zh-hans\/%e9%a8%b0%e7%9b%9b%e5%8d%9a%e8%97%a5%e9%a6%96%e6%ac%a1%e5%9c%a82024%e5%b9%b4%e7%be%8e%e5%9c%8b%e8%82%9d%e7%97%85%e7%a0%94%e7%a9%b6%e5%ad%b8%e6%9c%83-aasld-%e5%b9%b4%e6%9c%83%e4%b8%8a%e7%99%bc\/23263","title":{"rendered":"\u9a30\u76db\u535a\u85e5\u9996\u6b21\u57282024\u5e74\u7f8e\u570b\u809d\u75c5\u7814\u7a76\u5b78\u6703 (AASLD) \u5e74\u6703\u4e0a\u767c\u5e03siRNA (Elebsiran) \u806f\u5408PEG-IFN\u03b1 \u5c0d\u6bd4PEG-IFN\u03b1 \u55ae\u85e5\u6cbb\u7642\u7684\u7d50\u679c\uff0c\u8b49\u660e\u806f\u5408siRNA\u53ef\u66f4\u986f\u8457\u63d0\u9ad8HBV\u8868\u9762\u6297\u539f\u6e05\u9664"},"content":{"rendered":"

\u6b63\u5728\u9032\u884c\u76842\u671fENSURE\u7814\u7a76\u63d0\u4f9b\u768448\u5468\u6cbb\u7642\u7d50\u675f\u6578\u64da\u6e05\u695a\u5730\u8868\u660e\uff0celebsiran\u806f\u5408PEG-IFN\u03b1\u53ef\u5be6\u73fe\u66f4\u591a\u7372\u76ca\uff0c\u5f9e\u800c\u7372\u5f97\u66f4\u9ad8\u529f\u80fd\u6027\u6cbb\u6108\u7387<\/p>\n

\u7531\u516c\u53f8\u53ca\u5176\u5408\u4f5c\u4f19\u4f34\u958b\u5c55\u7684\u591a\u9805\u806f\u5408\u7814\u7a76\u6578\u64da\u5c07\u7e7c\u7e8c\u652f\u6301\u516c\u53f8\u7684\u7b56\u7565\uff0c\u5373\u901a\u904e\u6b63\u78ba\u7684\u806f\u5408\u6cbb\u7642\u65b9\u6848\u5728\u66f4\u5ee3\u6cdb\u7684\u60a3\u8005\u7fa4\u9ad4\u4e2d\u5be6\u73feHBV\u529f\u80fd\u6027\u6cbb\u6108<\/p>\n

\u4e2d\u570b\u5317\u4eac\u548c\u7f8e\u570b\u5317\u5361\u7f85\u4f86\u7d0d\u5dde\u9054\u52d2\u59c6<\/span>2024\u5e7411\u670819\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u9a30\u76db\u535a\u85e5\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8<\/a>\uff08\u300c\u9a30\u76db\u535a\u85e5\u300d\u6216\u300c\u516c\u53f8\u300d\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a2137.HK\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u91dd\u5c0d\u60a3\u8005\u91ab\u7642\u9700\u6c42\u672a\u88ab\u6eff\u8db3\u7684\u75be\u75c5\u958b\u767c\u6cbb\u7642\u65b9\u6848\uff0c\u4ee5\u6539\u5584\u60a3\u8005\u5065\u5eb7\u72c0\u6cc1\u548c\u6cbb\u7642\u9078\u64c7\u7684\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u572811\u670815\u65e5\u81f319\u65e5\u65bc\u7f8e\u570b\u52a0\u5229\u798f\u5c3c\u4e9e\u5dde\u8056\u5730\u4e9e\u54e5\u8209\u884c\u7684\u7f8e\u570b\u809d\u75c5\u7814\u7a76\u5b78\u6703\uff08AASLD\uff09\u5e74\u6703\u4e0a\uff0c\u4ee5\u6700\u65b0\u7a81\u7834\uff08late-breaking\uff09\u53e3\u982d\u5831\u544a\u7684\u5f62\u5f0f\u516c\u5e03\u4e86\u5176\u6b63\u5728\u9032\u884c\u76842\u671fENSURE\u7814\u7a76\u7684\u6700\u65b0\u6578\u64da\u3002<\/p>\n

\n<\/div>\n

ENSURE\u662f\u4e00\u9805\u967d\u6027\u5c0d\u7167\u3001\u96a8\u6a5f\u30012\u671f\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u8a66\u9a57\u6027\u5c0f\u5e72\u64fe\u6838\u7cd6\u6838\u9178\uff08siRNA\uff09elebsiran\uff08BRII-835\uff0cVIR-2218\uff09\u806f\u5408\u805a\u4e59\u4e8c\u9187\u5e72\u64fe\u7d20\u03b1\uff08PEG-IFN\u03b1\uff09\u5c0d\u4e59\u578b\u809d\u708e\u8868\u9762\u6297\u539f\uff08HBsAg\uff09\u57fa\u7dda\u70ba100-3,000 IU\/mL\u7684\u6162\u6027HBV\u611f\u67d3\u8005\u7684\u4f5c\u7528\u3002\u8a72\u7814\u7a76\u6392\u9664\u4e86HBsAg\u57fa\u7dda\u6c34\u5e73\u8f03\u4f4e\uff08<100 IU\/mL\uff09\u7684HBV\u60a3\u8005\uff0c\u4ee5\u7814\u7a76\u5728\u66f4\u5ee3\u6cdb\u60a3\u8005\u7fa4\u9ad4\u4e2d\u7684\u6f5b\u5728\u7642\u6548\u3002ENSURE 48\u5468\u6cbb\u7642\u7d50\u675f\uff08EOT\uff09\u6578\u64da\u986f\u793a\uff0c\u5728\u6cbb\u7642\u7d50\u675f\u6642\uff0c\u63a5\u53d7200 mg\u6216100 mg elebsiran\u806f\u5408PEG-IFN\u03b1\u6cbb\u7642\u7684\u53c3\u8207\u8005\u4e2d\u5206\u5225\u670926.3%\uff085\/19\uff09\u621633.3%\uff086\/18\uff09\u5be6\u73feHBsAg\u8840\u6e05\u6e05\u9664\uff0c\u800c\u63a5\u53d7PEG-IFN\u03b1\u55ae\u85e5\u6cbb\u7642\u7684\u53c3\u8207\u8005\u4e2d\u53ea\u67095.6%\uff081\/18\uff09\u5be6\u73feHBsAg\u8840\u6e05\u6e05\u9664\u3002<\/p>\n

\u9996\u90fd\u91ab\u79d1\u5927\u5b78\u9644\u5c6c\u5317\u4eac\u53cb\u8abc\u91ab\u9662\u809d\u75c5\u4e2d\u5fc3\u4e3b\u4efb\u8cc8\u7e7c\u6771\u6559\u6388\u8868\u793a\uff1a\u300cENSURE\u7814\u7a76\u7684EOT\u6578\u64da\u975e\u5e38\u660e\u78ba\u3002\u65e2\u5f80\u7814\u7a76\u986f\u793a\uff0csiRNA\u806f\u5408PEG-IFN\u03b1\u662f\u6700\u6709\u5e0c\u671b\u7372\u5f97\u66f4\u9ad8HBsAg\u8840\u6e05\u6e05\u9664\u7684\u7642\u6cd5\u4e4b\u4e00\u3002ENSURE\u7814\u7a76\u9996\u6b21\u70basiRNA\u5728\u5df2\u6709\u7684PEG-IFN\u03b1\u7642\u6cd5\u57fa\u790e\u4e0a\u5c0d\u5be6\u73fe\u529f\u80fd\u6027\u6cbb\u6108\u7684\u4f5c\u7528\u63d0\u4f9b\u4e86\u8b49\u64da\u3002\u6211\u5011\u76f8\u4fe1\uff0celebsiran\u6709\u671b\u5c0d\u63d0\u9ad8HBV\u529f\u80fd\u6027\u6cbb\u6108\u7387\u7522\u751f\u91cd\u8981\u5f71\u97ff\u3002\u300d<\/p>\n

\u9a30\u76db\u535a\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98David Margolis\u535a\u58eb\u8868\u793a\uff1a\u300c\u9019\u9805\u8a66\u9a57\u6578\u64da\u4ee4\u6211\u5011\u5099\u53d7\u9f13\u821e\uff0c\u5b83\u5c07\u7e7c\u7e8c\u652f\u6301\u6211\u5011\u5728\u76ee\u6a19\u4eba\u7fa4\u4e2d\u958b\u767c\u6162\u6027HBV\u529f\u80fd\u6027\u6cbb\u6108\u7642\u6cd5\u7684\u76ee\u6a19\u3002\u8a72\u7d50\u679c\u51f8\u986f\u4e86elebsiran\u4f5c\u70ba\u76ee\u524d\u6b63\u5728\u958b\u5c55\u7684\u591a\u9805\u81e8\u5e8a\u7814\u7a76\u4e2d\u9032\u884c\u8a55\u4f30\u7684\u806f\u5408\u6cbb\u7642\u65b9\u6848\u6838\u5fc3\u7684\u6f5b\u529b\u3002\u6211\u5011\u671f\u5f85\u8457\u901a\u904e\u6b63\u5728\u9032\u884c\u76842\u671f\u7814\u7a76\uff0c\u5c07elebsiran\u8207\u5176\u4ed6\u7642\u6cd5\u76f8\u7d50\u5408\uff0c\u4ee5\u70ba\u5168\u74032.54\u5104\u6162\u6027HBV\u611f\u67d3\u8005\u63d0\u4f9b\u66f4\u9ad8\u7684\u529f\u80fd\u6027\u6cbb\u6108\u7387\u3002\u300d<\/p>\n

\u6458\u8981\u7de8\u865f\uff1a5008
\u6700\u65b0\u7a81\u7834\u53e3\u982d\u5831\u544a\u6a19\u984c\uff1aElebsiran\uff08BRII-835\uff09\u806f\u5408\u805a\u4e59\u4e8c\u9187\u5e72\u64fe\u7d20\u03b1\uff08PEG-IFN\u03b1\uff09\u5c0d\u6bd4 PEG-IFN\u03b1 \u5728\u75c5\u6bd2\u5b78\u6291\u5236\u7684\u6162\u6027\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u8005\u4e2d\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u7684\u521d\u6b65\u7d50\u679c
\u8b1b\u8005\uff1a\u8cc8\u7e7c\u6771\u6559\u6388\uff0c\u9996\u90fd\u91ab\u79d1\u5927\u5b78\u9644\u5c6c\u5317\u4eac\u53cb\u8abc\u91ab\u9662\u809d\u75c5\u4e2d\u5fc3\u4e3b\u4efb<\/p>\n

\u5728\u6cbb\u7642\u7d50\u675f\u6642\uff0celebsiran 200 mg + PEG-IFN\u03b1\u968a\u5217\u548celebsiran 100 mg + PEG-IFN\u03b1\u968a\u5217\u7684HBsAg\u8840\u6e05\u6e05\u9664\u7387\u5206\u5225\u70ba26.3%\uff085\/19\uff09\u548c33.3%\uff086\/18\uff09\uff0c\u660e\u986f\u9ad8\u65bcPEG-IFN\u03b1\u55ae\u85e5\u6cbb\u7642\u968a\u5217\uff085.6%\uff09\u3002 \u5728HBsAg\u57fa\u7dda\u70ba100-1,500 IU\/mL\u7684\u4e9e\u7d44\u4e2d\uff0c\u63a5\u53d7elebsiran 200 mg\u6216100 mg\u806f\u5408PEG-IFN\u03b1\u6cbb\u7642\u5f8c\u5206\u5225\u670931.3%\uff085\/16\uff09\u621640.0%\uff086\/15\uff09\u7684\u53c3\u8207\u8005\u5be6\u73fe\u4e86HBsAg\u8840\u6e05\u6e05\u9664\u3002 Elebsiran + PEG-IFN\u03b1\u968a\u5217\u5728\u6cbb\u7642\u7d50\u675f\u6642\u7684HBsAg\u4e0b\u964d\u5e45\u5ea6\uff08\u5e73\u5747\u503c[SE]\uff1aelebsiran 200 mg\u6216100 mg\u5206\u5225\u70ba-2.47 [0.28]\u6216-3.01 [0.28] log10 IU\/mL\uff09\u5927\u65bc PEG-IFN\u03b1\u968a\u5217\uff08-1.02 [0.30] log10 IU\/mL\uff09\u3002 \u5728HBsAg\u57fa\u7dda\u6c34\u5e73\u70ba100-3,000 IU\/mL\u7684\u53c3\u8207\u8005\u4e2d\uff0c elebsiran 200 mg\u548c100 mg\u5291\u91cf\u806f\u5408PEG-IFN\u03b1\u53ef\u5be6\u73fe\u76f8\u4f3c\u7684HBsAg\u8840\u6e05\u6e05\u9664\u7387\u548cHBsAg\u964d\u5e45\u3002 \u5728\u75c5\u6bd2\u5b78\u6291\u5236\u7684\u6162\u6027HBV\u611f\u67d3\u53c3\u8207\u8005\u4e2d\uff0celebsiran\u806f\u5408PEG-IFN\u03b1\u6cbb\u7642\u7e3d\u9ad4\u5b89\u5168\u4e14\u8010\u53d7\u6027\u826f\u597d\u3002 \u6cbb\u7642\u5f8c\u96a8\u8a2a\u4ecd\u5728\u9032\u884c\u4e2d\uff0c\u5c07\u5728\u6cbb\u7642\u7d50\u675f\u5f8c\u7e7c\u7e8c\u96a8\u8a2a24\u5468\u3002 <\/p>\n

\u4f5c\u70ba\u9a30\u76db\u535a\u85e5\u958b\u767cHBV\u529f\u80fd\u6027\u6cbb\u6108\u7368\u7279\u65b9\u6cd5\u7684\u4e00\u90e8\u5206\uff0c\u516c\u53f8\u53ca\u5176\u5408\u4f5c\u4f19\u4f34\u6b63\u5728\u7a4d\u6975\u63a8\u9032\u6211\u5011\u5dee\u7570\u5316\u7522\u54c1\u7d44\u5408\u7684\u591a\u9805\u806f\u5408\u7814\u7a76\uff0c\u5305\u62ecelebsiran\u3001\u91dd\u5c0dHBV\u7684\u5728\u7814\u5ee3\u8b5c\u4e2d\u548c\u6027\u55ae\u514b\u9686\u6297\u9ad4tobevibart\uff0c\u4ee5\u53ca\u91cd\u7d44\u86cb\u767dHBV\u514d\u75ab\u6cbb\u7642\u85e5\u7269BRII-179\u3002\u6211\u5011\u5c07\u57282025\u5e74\u7684\u79d1\u5b78\u6703\u8b70\u4e0a\u5206\u4eab\u95dc\u9375\u6578\u64da\u3002<\/p>\n

\u95dc\u65bc\u4e59\u578b\u809d\u708e<\/p>\n

\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u662f\u4e16\u754c\u4e0a\u6700\u91cd\u5927\u7684\u611f\u67d3\u6027\u75be\u75c5\u5a01\u8105\u4e4b\u4e00\uff0c\u5168\u7403\u611f\u67d3\u4eba\u6578\u8d85\u904e2.54\u5104\u3002[1]\u6162\u6027HBV\u611f\u67d3\u662f\u809d\u9ad2\u75be\u75c5\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u6bcf\u5e74\u7d04\u670982\u842c\u4eba\u6b7b\u65bc\u6162\u6027HBV\u611f\u67d3\u7684\u4e26\u767c\u75c7\u3002[1]\u4e2d\u570b\u6162\u6027HBV\u611f\u67d3\u4eba\u6578\u90548,700\u842c\uff0c\u975e\u5e38\u503c\u5f97\u95dc\u6ce8\u3002[2]<\/p>\n

\u95dc\u65bcElebsiran\uff08BRII-835\uff0cVIR-2218\uff09<\/p>\n

Elebsiran\u662f\u4e00\u7a2e\u7d93\u76ae\u4e0b\u6ce8\u5c04\u7d66\u85e5\u7684\u9776\u5411\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u7684\u5c0f\u5e72\u64fe\u6838\u7cd6\u6838\u9178\uff08siRNA\uff09\u7814\u7a76\u6027\u85e5\u7269\uff0c\u65e8\u5728\u964d\u89e3HBV RNA\u8f49\u9304\u672c\u53ca\u9650\u5236\u4e59\u578b\u809d\u708e\u8868\u9762\u6297\u539f\u7684\u7522\u751f\uff0c\u5176\u5177\u6709\u91dd\u5c0dHBV\u53ca\u4e01\u578b\u809d\u708e\u75c5\u6bd2\uff08HDV\uff09\u7684\u76f4\u63a5\u6297\u75c5\u6bd2\u6d3b\u6027\u3002\u5176\u662f\u9996\u500b\u9032\u5165\u81e8\u5e8a\u7684\u91c7\u7528\u589e\u5f37\u7a69\u5b9a\u5316\u5b78\u589e\u5f37\u6280\u8853\u7684siRNA\uff0c\u4ee5\u589e\u5f37\u7a69\u5b9a\u6027\u4e26\u6700\u5927\u7a0b\u5ea6\u5730\u6e1b\u5c11\u812b\u9776\u6d3b\u6027\uff0c\u5f9e\u800c\u6709\u53ef\u80fd\u63d0\u9ad8\u6cbb\u7642\u6307\u6578\u3002\u9a30\u76db\u535a\u85e5\u65bc2020\u5e74\u5f9eVir Biotechnology, Inc. \u7372\u5f97\u4e86\u5728\u5927\u4e2d\u83ef\u5730\u5340\u958b\u767c\u548c\u5546\u696d\u5316elebsiran\u7684\u7368\u5bb6\u6b0a\u76ca\u3002<\/p>\n

\u95dc\u65bc\u9a30\u76db\u535a\u85e5<\/p>\n

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[1] World Health Organization. (April 2024<\/span>). Global hepatitis report 2024: action for access in low- and middle-income countries. World Health Organization. Retrieved from https:\/\/www.who.int\/publications\/i\/item\/9789240091672<\/a>\u00a0<\/p>\n

[2] World Health Organization. Hepatitis. World Health Organization. Retrieved from https:\/\/www.who.int\/china\/health-topics\/hepatitis#:~:text=There%20are%2087%20million%20people,living%20with%20chronic%20hepatitis%20C<\/a>.<\/p>","protected":false},"excerpt":{"rendered":"

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