{"id":23040,"date":"2024-11-07T11:30:00","date_gmt":"2024-11-07T03:30:00","guid":{"rendered":"https:\/\/www.franchise.com.hk\/%e6%ad%8c%e7%a6%ae%e5%ae%a3%e4%bd%88%e5%90%8c%e9%a1%9e%e9%a6%96%e5%89%b5%e6%b2%bb%e7%99%82%e8%82%a5%e8%83%96%e7%97%87%e7%9a%84%e6%b8%9b%e9%87%8d%e4%b8%8d%e6%b8%9b%e8%82%8c%e5%80%99%e9%81%b8%e8%97%a5\/23040"},"modified":"2024-11-07T11:30:00","modified_gmt":"2024-11-07T03:30:00","slug":"%e6%ad%8c%e7%a6%ae%e5%ae%a3%e4%bd%88%e5%90%8c%e9%a1%9e%e9%a6%96%e5%89%b5%e6%b2%bb%e7%99%82%e8%82%a5%e8%83%96%e7%97%87%e7%9a%84%e6%b8%9b%e9%87%8d%e4%b8%8d%e6%b8%9b%e8%82%8c%e5%80%99%e9%81%b8%e8%97%a5","status":"publish","type":"post","link":"https:\/\/www.franchise.com.hk\/zh-hans\/%e6%ad%8c%e7%a6%ae%e5%ae%a3%e4%bd%88%e5%90%8c%e9%a1%9e%e9%a6%96%e5%89%b5%e6%b2%bb%e7%99%82%e8%82%a5%e8%83%96%e7%97%87%e7%9a%84%e6%b8%9b%e9%87%8d%e4%b8%8d%e6%b8%9b%e8%82%8c%e5%80%99%e9%81%b8%e8%97%a5\/23040","title":{"rendered":"\u6b4c\u79ae\u5ba3\u4f48\u540c\u985e\u9996\u5275\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u6e1b\u91cd\u4e0d\u6e1b\u808c\u5019\u9078\u85e5\u7269ASC47\u5728\u6fb3\u5927\u5229\u4e9e\u9032\u884c\u7684\u81e8\u5e8aI\u671f\u7814\u7a76\u53d6\u5f97\u7a4d\u6975\u7d50\u679c"},"content":{"rendered":"<p>-\u5728\u6fb3\u5927\u5229\u4e9e\u9032\u884c\u7684\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u81bd\u56fa\u9187\uff08LDL-C\uff09\u504f\u9ad8\u53d7\u8a66\u8005I\u671f\u55ae\u5291\u91cf\u905e\u589e\uff08SAD\uff09\u7814\u7a76\u6578\u64da\u986f\u793a\uff0c\u76ae\u4e0b\u6ce8\u5c04ASC47\u7684\u534a\u8870\u671f\u9577\u905421\u5929\uff0c\u652f\u6301\u5728\u80a5\u80d6\u75c7\u60a3\u8005\u4e2d\u6bcf\u6708\u7d66\u85e5\u4e00\u6b21<\/p>\n<p>-\u5728\u4f7f\u7528\u98f2\u98df\u8a98\u767c\u80a5\u80d6\uff08DIO\uff09\u5c0f\u9f20\u6a21\u578b\u7684\u591a\u9805\u81e8\u5e8a\u524d\u7814\u7a76\u4e2d\uff0cASC47\u986f\u793a\u51fa\u4e86\u5065\u5eb7\u7684\u6e1b\u91cd\u6548\u679c\uff08\u6e1b\u91cd\u4e0d\u6e1b\u808c\uff09<\/p>\n<p>-\u5728\u4e00\u9805\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\uff08semaglutide\uff09\u9032\u884c\u982d\u5c0d\u982d\u6bd4\u8f03\u7684DIO\u5c0f\u9f20\u6a21\u578b\u81e8\u5e8a\u524d\u7814\u7a76\u4e2d\uff0cASC47\u6cbb\u7642\u7d44DIO\u5c0f\u9f20\u7e3d\u9ad4\u8102\u91cf\u6e1b\u5c11\uff08-63.5%\uff09\uff0c\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\uff08-39.6%\uff09\u76f8\u6bd4\uff0c\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u3002\u5728\u540c\u4e00\u9805\u7814\u7a76\u4e2d\uff0cASC47\u6cbb\u7642\u7d44DIO\u5c0f\u9f20\u808c\u8089\u7e3d\u91cf\u7d71\u8a08\u5b78\u986f\u8457\u6027\u589e\u52a0\uff08+5.8%\uff09\uff0c\u800c\u53f8\u7f8e\u683c\u9b6f\u80bd\u6cbb\u7642\u7d44DIO\u5c0f\u9f20\u808c\u8089\u7e3d\u91cf\u6e1b\u5c11\uff08-9.3%\uff09\u3002\u96d6\u7136ASC47\u6cbb\u7642\u7d44DIO\u5c0f\u9f20\u7684\u71b1\u91cf\u651d\u5165\u6e1b\u5c11\u91cf\u660e\u986f\u4f4e\u65bc\u53f8\u7f8e\u683c\u9b6f\u80bd\u6cbb\u7642\u7d44DIO\u5c0f\u9f20\uff0c\u4f46ASC47\uff08-24.6%\uff09\u548c\u53f8\u7f8e\u683c\u9b6f\u80bd\uff08-23.1%\uff09\u7684\u7e3d\u9ad4\u91cd\u964d\u4f4e\u6548\u679c\u76f8\u4f3c<\/p>\n<p>-\u5728\u4e00\u9805\u8207\u66ff\u723e\u6cca\u80bd\uff08tirzepatide\uff09\u9032\u884c\u982d\u5c0d\u982d\u6bd4\u8f03\u7684DIO\u5c0f\u9f20\u6a21\u578b\u81e8\u5e8a\u524d\u7814\u7a76\u4e2d\uff0cASC47\u6cbb\u7642\u7d44DIO\u5c0f\u9f20\u7e3d\u9ad4\u8102\u91cf\u6e1b\u5c11\uff08-68.0%\uff09\uff0c\u8207\u66ff\u723e\u6cca\u80bd\uff08-50.4%\uff09\u76f8\u6bd4\uff0c\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u3002\u5728\u540c\u4e00\u9805\u7814\u7a76\u4e2d\uff0cASC47\u6cbb\u7642\u7d44DIO\u5c0f\u9f20\u808c\u8089\u7e3d\u91cf\u7d71\u8a08\u5b78\u986f\u8457\u6027\u589e\u52a0\uff08+8.1%\uff09\uff0c\u800c\u66ff\u723e\u6cca\u80bd\u6cbb\u7642\u7d44DIO\u5c0f\u9f20\u808c\u8089\u7e3d\u91cf\u6e1b\u5c11\uff08-3.8%\uff09\u3002\u96d6\u7136ASC47\u6cbb\u7642\u7d44DIO\u5c0f\u9f20\u7684\u71b1\u91cf\u651d\u5165\u6e1b\u5c11\u91cf\u660e\u986f\u4f4e\u65bc\u66ff\u723e\u6cca\u80bd\u6cbb\u7642\u7d44DIO\u5c0f\u9f20\uff0c\u4f46ASC47\uff08-23.6%\uff09\u548c\u66ff\u723e\u6cca\u80bd\uff08-22.4%\uff09\u7684\u7e3d\u9ad4\u91cd\u964d\u4f4e\u6548\u679c\u76f8\u4f3c<\/p>\n<p>-ASC47\u5728\u8a2d\u8a08\u4e0a\u5177\u6709\u7368\u7279\u7684\u5dee\u7570\u5316\u7279\u6027\uff0c\u80fd\u5920\u9776\u5411\u905e\u9001\u81f3\u8102\u80aa\u7d44\u7e54\uff0c\u5f9e\u800c\u5728\u8102\u80aa\u7d44\u7e54\u4e2d\u7522\u751f\u5291\u91cf\u4f9d\u8cf4\u6027\u7684\u9ad8\u85e5\u7269\u6fc3\u5ea6\u3002\u5c0dDIO\u5c0f\u9f20\u9032\u884c15\u6beb\u514b\/\u516c\u65a4\u3001\u6bcf\u5169\u9031\u4e00\u6b21\u7684ASC47\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6700\u5f8c\u4e00\u6b21\u7d66\u85e514\u5929\u5f8c\uff0c\u8102\u80aa\u7d44\u7e54\u4e2d\u7684\u85e5\u7269\u6fc3\u5ea6\u9054\u5230\u4e86\u7531\u4e00\u9805\u81e8\u5e8a\u524d\u6a21\u578b\u9810\u6e2c\u7684\u4eba\u9ad4\u6709\u6548\u85e5\u7269\u6fc3\u5ea6\u76847\u500d<\/p>\n<p>-\u901a\u904e\u89e3\u5076\u806f\u86cb\u767d-1\uff08uncoupling protein 1\u6216UCP-1\uff09\u4ecb\u5c0e\u8102\u80aa\u7d44\u7e54\u7522\u71b1\u662fASC47\u6e1b\u8102\u4e26\u5be6\u73fe\u6e1b\u91cd\u4e0d\u6e1b\u808c\u7684\u95dc\u9375\u4f5c\u7528\u6a5f\u5236\u4e4b\u4e00<\/p>\n<p><span class=\"legendSpanClass\">\u9999\u6e2f<\/span><span class=\"legendSpanClass\">2024\u5e7411\u67087\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a1672\uff0c\u300c\u6b4c\u79ae\u300d\uff09\u5ba3\u4f48\u5176\u7528\u65bc\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u540c\u985e\u9996\u5275\u3001\u6e1b\u91cd\u4e0d\u6e1b\u808c\u5019\u9078\u85e5\u7269ASC47\u5728\u6fb3\u5927\u5229\u4e9e\u9032\u884c\u7684\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u81bd\u56fa\u9187\uff08LDL-C\uff09\u504f\u9ad8\u53d7\u8a66\u8005I\u671f\u55ae\u5291\u91cf\u905e\u589e\uff08SAD\uff09\u7814\u7a76\uff08<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT06427590?term=NCT06427590&amp;rank=1\" target=\"_blank\" rel=\"noopener\">NCT06427590<\/a>\uff09\u7684\u9802\u7dda\u7d50\u679c\u3002<\/p>\n<p>I\u671f\u81e8\u5e8a\u6578\u64da<\/p>\n<p>\u5728\u63a5\u53d7\u76ae\u4e0b\u6ce8\u5c04\u8d85\u9577\u6548ASC47\u7684LDL-C\u504f\u9ad8\u53d7\u8a66\u8005\uff08LDL-C &gt; 110 mg\/dL\uff082.8 mmol\/L\uff09\uff09\u4e2d\uff0cASC47\u986f\u793a\u51fa\u4e86\u9577\u905421\u5929\u7684\u534a\u8870\u671f\uff0c\u652f\u6301\u5728\u80a5\u80d6\u75c7\u60a3\u8005\u4e2d\u6bcf\u6708\u7d66\u85e5\u4e00\u6b21\u3002\u6b64\u5916\uff0c\u5728\u55ae\u6b21\u76ae\u4e0b\u6ce8\u5c04\u5f8c\u7684\u7b2c29\u5929\uff0cASC47\u9776\u5411\u7d50\u5408\u826f\u597d\uff0c\u8868\u73fe\u70ba\u8102\u8cea\u751f\u7269\u6a19\u8a8c\u7269\u4ecd\u6709\u986f\u8457\u964d\u4f4e\u3002<\/p>\n<p>\u5728LDL-C\u504f\u9ad8\u53d7\u8a66\u8005\u4e2d\u958b\u5c55\u7684ASC47\u55ae\u85e5SAD\u7814\u7a76\u5305\u542b5\u500b\u968a\u5217\uff0c\u53d7\u8a66\u8005\u901a\u904e\u76ae\u4e0b\u6ce8\u5c04\u5206\u5225\u63a5\u53d710\u6beb\u514b\u300130\u6beb\u514b\u300190\u6beb\u514b\u3001180\u6beb\u514b\u3001360\u6beb\u514bASC47\u6216\u5b89\u6170\u5291\u3002\u55ae\u6b21\u76ae\u4e0b\u6ce8\u5c04ASC47\u6216\u5b89\u6170\u5291\u5f8c\uff0c\u53d7\u8a66\u8005\u57288\u5468\u5167\u63a5\u53d7\u591a\u6b21\u9580\u8a3a\u96a8\u8a2a\u3002\u524d\u4e09\u500b\u968a\u5217\uff0810\u6beb\u514b\u300130\u6beb\u514b\u548c90\u6beb\u514b\uff09\u53d7\u8a66\u8005\u7684\u7d66\u85e5\u5df2\u5b8c\u6210\uff0c\u4e09\u500b\u968a\u5217\u517120\u540dLDL-C\u504f\u9ad8\u53d7\u8a66\u8005\u63a5\u53d7\u4e86ASC47\u6216\u5b89\u6170\u5291\u6ce8\u5c04\u3002ASC47\u986f\u793a\u51fa\u4e86\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u7121\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08SAE\uff09\u767c\u751f\uff0c\u4e5f\u672a\u767c\u751f\u56e0\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u800c\u5c0e\u81f4\u7684\u505c\u85e5\u3002\u5927\u591a\u6578AE\u70ba\u8f15\u5ea6\uff081\u7d1a\uff09\u3002\u50c52\u540d\u53d7\u8a66\u8005\uff082\/20\uff09\u5831\u544a\u4e86\u8f15\u5ea6\u7684\u6ce8\u5c04\u90e8\u4f4d\u53cd\u61c9\uff08\u50c51\u7d1a\uff09\u3002\u6c92\u6709\u5831\u544a\u80c3\u8178\u9053\u548c\u5fc3\u81dfAE\u3002\u6c92\u6709\u5831\u544a\u809d\u9176\u7570\u5e38\u3002\u5728\u5be6\u9a57\u5ba4\u6aa2\u67e5\u3001\u5fc3\u96fb\u5716\u3001\u751f\u547d\u9ad4\u5f81\u6216\u9ad4\u683c\u6aa2\u67e5\u4e2d\u672a\u89c0\u5bdf\u5230\u5177\u6709\u81e8\u5e8a\u610f\u7fa9\u7684\u767c\u73fe\u9805\u3002<\/p>\n<p>\u57fa\u65bc\u5728LDL-C\u504f\u9ad8\u53d7\u8a66\u8005\u4e2d\u958b\u5c55\u7684ASC47\u55ae\u85e5SAD\u7814\u7a76\u7684\u5b89\u5168\u6027\u3001\u85e5\u4ee3\u52d5\u529b\u5b78\u548c\u9776\u5411\u7d50\u5408\u6578\u64da\uff0c\u7b2c\u4e8c\u9805I\u671f\u7814\u7a76\uff08ASC47\u55ae\u85e5\u5728\u80a5\u80d6\u75c7\u60a3\u8005\u4e2d\u7684SAD\u7814\u7a76\uff09\u5df2\u5728\u6fb3\u5927\u5229\u4e9e\u958b\u5c55\u3002\u9810\u8a08\u5c07\u65bc2025\u5e74\u7b2c\u4e00\u5b63\u5ea6\u7372\u5f97\u9802\u7dda\u6578\u64da\u3002<\/p>\n<p>ASC47\u5728\u6fb3\u5927\u5229\u4e9e\u9084\u6709\u53e6\u5916\u5169\u9805I\u671f\u7814\u7a76\uff1a\u5728\u80a5\u80d6\u75c7\u60a3\u8005\u4e2d\u9032\u884cASC47\u55ae\u85e5\u6cbb\u7642\u7684\u591a\u5291\u91cf\u905e\u589e\uff08MAD\uff09\u7814\u7a76\uff0c\u4ee5\u53ca\u5728\u80a5\u80d6\u75c7\u60a3\u8005\u4e2d\u9032\u884cASC47\u806f\u5408\u66ff\u723e\u6cca\u80bd\u6216\u53f8\u7f8e\u683c\u9b6f\u80bd\u7684MAD\u7814\u7a76\u3002\u9019\u4e9b\u8a66\u9a57\u7684\u8a73\u7d30\u81e8\u5e8a\u6578\u64da\u9810\u8a08\u5c07\u57282025\u5e74\u7684\u91ab\u5b78\u6703\u8b70\u4e0a\u516c\u4f48\u3002<\/p>\n<p>\u81e8\u5e8a\u524d\u85e5\u6548\u6578\u64da<\/p>\n<p>\u5728\u5169\u9805\u5206\u5225\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\u548c\u66ff\u723e\u6cca\u80bd\u9032\u884c\u982d\u5c0d\u982d\u6bd4\u8f03\u7684\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08DIO\uff09\u5c0f\u9f20\u6a21\u578b\u7814\u7a76\u4e2d\uff0cASC47\u55ae\u85e5\u7642\u6cd5\u986f\u793a\u51fa\u4e86\u5291\u91cf\u4f9d\u8cf4\u6027\u7684\u5065\u5eb7\u6e1b\u91cd\u6548\u679c\uff08\u6e1b\u91cd\u4e0d\u6e1b\u808c\uff09\u3002\u5728\u9019\u5169\u9805\u7814\u7a76\u4e2d\uff0c\u76ae\u4e0b\u6ce8\u5c04\u4f4e\u5291\u91cf\u7684ASC47\uff0815\u6beb\u514b\/\u516c\u65a4\u548c45\u6beb\u514b\/\u516c\u65a4\uff0c\u6bcf\u5169\u9031\u4e00\u6b21\u6216\u6bcf\u9031\u4e00\u6b21\uff09\u5747\u8868\u73fe\u51fa\u4e86\u5177\u6709\u81e8\u5e8a\u610f\u7fa9\u7684\u6e1b\u91cd\u6548\u679c\u3002\u9019\u4e9b\u5728\u5c0f\u9f20\u4e2d\u7684\u5be6\u9a57\u5291\u91cf\u9810\u6e2c\u53ef\u8f49\u5316\u70ba\u9069\u7528\u4eba\u9ad4\u7684\u81e8\u5e8a\u5291\u91cf\u3002<\/p>\n<p>\u5728DIO\u5c0f\u9f20\u7814\u7a76\u4e2d\uff0c\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\uff0830\u7d0d\u6469\u723e\/\u516c\u65a4\uff0c\u6bcf\u65e5\u4e00\u6b21\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff09\u76f8\u6bd4\uff0c\u81e8\u5e8a\u76f8\u95dc\u5291\u91cf\u7684ASC47\uff0845\u6beb\u514b\/\u516c\u65a4\uff0c\u6bcf\u5169\u9031\u4e00\u6b21\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff09\u6cbb\u7642\u7d44DIO\u5c0f\u9f20\u7e3d\u9ad4\u8102\u91cf\u6e1b\u5c11\uff08-63.5%\uff0cp=0.007 vs\u53f8\u7f8e\u683c\u9b6f\u80bd\uff09\uff0c\u591a\u65bc\u53f8\u7f8e\u683c\u9b6f\u80bd\u6cbb\u7642\u7d44DIO\u5c0f\u9f20\u7e3d\u9ad4\u8102\u91cf\u6e1b\u5c11\uff08-39.6%\uff09\uff0c\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\uff08\u88681\uff09\u3002ASC47\u6cbb\u7642\u7d44DIO\u5c0f\u9f20\u808c\u8089\u7e3d\u91cf\u589e\u52a0\uff08+5.8%\uff0cp&lt;0.0001 vs\u53f8\u7f8e\u683c\u9b6f\u80bd\uff09\uff0c\u800c\u53f8\u7f8e\u683c\u9b6f\u80bd\u6cbb\u7642\u7d44DIO\u5c0f\u9f20\u808c\u8089\u7e3d\u91cf\u6e1b\u5c11\uff08-9.3%\uff09\uff08\u88681\uff09\u3002\u96d6\u7136ASC47\u6cbb\u7642\u7d44DIO\u5c0f\u9f20\u7684\u71b1\u91cf\u651d\u5165\u6e1b\u5c11\u91cf\u660e\u986f\u4f4e\u65bc\u53f8\u7f8e\u683c\u9b6f\u80bd\u6cbb\u7642\u7d44DIO\u5c0f\u9f20\uff0c\u4f46ASC47\uff08-24.6%\uff09\u548c\u53f8\u7f8e\u683c\u9b6f\u80bd\uff08-23.1%\uff09\u7684\u7e3d\u9ad4\u91cd\u964d\u4f4e\u6548\u679c\u76f8\u4f3c\uff08\u88681\uff09\u3002<\/p>\n<p>\u88681. ASC47\u5728DIO\u5c0f\u9f20\u6a21\u578b\u4e2d\u6e1b\u8102\u589e\u808c\u6548\u679c\u5448\u5291\u91cf\u4f9d\u8cf4\u6027\u4e14\u982d\u5c0d\u982d\u6bd4\u8f03\u512a\u65bc\u53f8\u7f8e\u683c\u9b6f\u80bd<\/p>\n<div>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u85e5\u7269<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u7d66\u85e5\u65b9\u6848<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u7e3d\u9ad4\u91cd\u8b8a\u5316<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u7e3d\u9ad4\u8102\u91cf\u8b8a\u5316<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u808c\u8089\u7e3d\u91cf\u8b8a\u5316<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">ASC47<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">15\u6beb\u514b\/\u516c\u65a4 <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u5169\u9031\u4e00\u6b21<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">-14.4\u00a0%<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">-37.8\u00a0%<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">+3.9%<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(p&lt;0.0001 vs \u53f8\u7f8e\u683c\u9b6f\u80bd)<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">ASC47<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">45\u6beb\u514b\/\u516c\u65a4 <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u5169\u9031\u4e00\u6b21<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">-24.6\u00a0%<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">-63.5%<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(p=0.007 vs \u53f8\u7f8e\u683c\u9b6f\u80bd)<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">+5.8% <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(p&lt;0.0001 vs \u53f8\u7f8e\u683c\u9b6f\u80bd)<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u53f8\u7f8e\u683c\u9b6f\u80bd<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">30\u7d0d\u6469\u723e\/\u516c\u65a4\u00a0 <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u65e5\u4e00\u6b21<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">-23.1\u00a0%<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">-39.6\u00a0%<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">-9.3\u00a0%<\/span><\/p>\n<\/div>\n<p>\u00a0<\/p>\n<p>\u5728DIO\u5c0f\u9f20\u7814\u7a76\u4e2d\uff0c\u8207\u66ff\u723e\u6cca\u80bd\uff083\u7d0d\u6469\u723e\/\u516c\u65a4\uff0c\u6bcf\u65e5\u4e00\u6b21\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff09\u76f8\u6bd4\uff0c\u81e8\u5e8a\u76f8\u95dc\u5291\u91cf\u7684ASC47\uff0845\u6beb\u514b\/\u516c\u65a4\uff0c\u6bcf\u9031\u4e00\u6b21\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff09\u6cbb\u7642\u7d44DIO\u5c0f\u9f20\u7e3d\u9ad4\u8102\u91cf\u6e1b\u5c11\uff08-68%\uff0cp=0.01 vs \u66ff\u723e\u6cca\u80bd\uff09\uff0c\u591a\u65bc\u66ff\u723e\u6cca\u80bd\u6cbb\u7642\u7d44DIO\u5c0f\u9f20\u7e3d\u9ad4\u8102\u91cf\u6e1b\u5c11\uff08-50.4%\uff09\uff0c\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\uff08\u88682\uff09\u3002ASC47\u6cbb\u7642\u7d44DIO\u5c0f\u9f20\u808c\u8089\u7e3d\u91cf\u589e\u52a0\uff08+8.1%\uff0cp=0.004 vs \u66ff\u723e\u6cca\u80bd\uff09\uff0c\u800c\u66ff\u723e\u6cca\u80bd\u6cbb\u7642\u7d44DIO\u5c0f\u9f20\u808c\u8089\u7e3d\u91cf\u6e1b\u5c11\uff08-3.8%\uff09\uff08\u88682\uff09\u3002\u96d6\u7136ASC47\u6cbb\u7642\u7d44DIO\u5c0f\u9f20\u7684\u71b1\u91cf\u651d\u5165\u6e1b\u5c11\u91cf\u660e\u986f\u4f4e\u65bc\u66ff\u723e\u6cca\u80bd\u6cbb\u7642\u7d44DIO\u5c0f\u9f20\uff0c\u4f46ASC47\uff08-23.6%\uff09\u548c\u66ff\u723e\u6cca\u80bd\uff08-22.4%\uff09\u7684\u7e3d\u9ad4\u91cd\u964d\u4f4e\u6548\u679c\u76f8\u4f3c\uff08\u88682\uff09\u3002<\/p>\n<p>\u88682. ASC47\u5728DIO\u5c0f\u9f20\u6a21\u578b\u4e2d\u6e1b\u8102\u589e\u808c\u6548\u679c\u5448\u5291\u91cf\u4f9d\u8cf4\u6027\u4e14\u982d\u5c0d\u982d\u6bd4\u8f03\u512a\u65bc\u66ff\u723e\u6cca\u80bd<\/p>\n<div>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u85e5\u7269<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u7d66\u85e5\u65b9\u6848<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u7e3d\u9ad4\u91cd\u8b8a\u5316<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u7e3d\u9ad4\u8102\u91cf\u8b8a\u5316<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u808c\u8089\u7e3d\u91cf\u8b8a\u5316<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">ASC47<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">15\u6beb\u514b\/\u516c\u65a4 <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u9031\u4e00\u6b21<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">-15.4\u00a0%<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">-46.1\u00a0%<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">+7.1% <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(p=0.009 vs \u66ff\u723e\u6cca\u80bd)<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">ASC47<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">45\u6beb\u514b\/\u516c\u65a4 <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u9031\u4e00\u6b21<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">-23.6\u00a0%<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">-68.0% <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(p=0.01 vs \u66ff\u723e\u6cca\u80bd)<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">+8.1% <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(p=0.004 vs \u66ff\u723e\u6cca\u80bd)<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u66ff\u723e\u6cca\u80bd<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">3\u7d0d\u6469\u723e\/\u516c\u65a4<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u65e5\u4e00\u6b21<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">-22.4\u00a0%<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">-50.4\u00a0%<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">-3.8\u00a0%<\/span><\/p>\n<\/div>\n<p>\u00a0<\/p>\n<p>ASC47\u2014\u2014\u8102\u80aa\u9776\u5411\u7684THR\u03b2\u9078\u64c7\u6027\u6fc0\u52d5\u5291<\/p>\n<p>ASC47\u662f\u4e00\u7a2e\u8102\u80aa\u9776\u5411\u7684\u7532\u72c0\u817a\u6fc0\u7d20\u53d7\u9ad4\u03b2\uff08THR\u03b2\uff09\u9078\u64c7\u6027\u5c0f\u5206\u5b50\u6fc0\u52d5\u5291\uff0c\u6709\u671b\u6210\u70ba\u540c\u985e\u9996\u5275\u7684\u6e1b\u91cd\u4e0d\u6e1b\u808c\u5019\u9078\u85e5\u7269\u3002ASC47\u662f\u6b4c\u79ae\u81ea\u4e3b\u7814\u767c\u7684\u4e00\u6b3e\u65b0\u5206\u5b50\u5be6\u9ad4\uff08NME\uff09\u3002<\/p>\n<p>ASC47\u5177\u6709\u7368\u7279\u7684\u5dee\u7570\u5316\u7279\u6027\uff0c\u80fd\u5920\u9776\u5411\u8102\u80aa\uff0c\u5f9e\u800c\u5728\u8102\u80aa\u7d44\u7e54\u4e2d\u7522\u751f\u5291\u91cf\u4f9d\u8cf4\u6027\u7684\u9ad8\u85e5\u7269\u6fc3\u5ea6\u3002\u5c0dDIO\u5c0f\u9f20\u9032\u884c15\u6beb\u514b\/\u516c\u65a4\u3001\u6bcf\u5169\u9031\u4e00\u6b21\u7684ASC47\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6700\u5f8c\u4e00\u6b21\u7d66\u85e514\u5929\u5f8c\uff0c\u8102\u80aa\u7d44\u7e54\u4e2d\u7684\u85e5\u7269\u6fc3\u5ea6\u9054\u5230\u4e86\u7531\u4e00\u9805\u81e8\u5e8a\u524d\u6a21\u578b\u9810\u6e2c\u7684\u4eba\u9ad4\u6709\u6548\u85e5\u7269\u6fc3\u5ea6\u76847\u500d\u3002\u8102\u80aa\u7d44\u7e54\u5728\u5305\u62ec\u80a5\u80d6\u75c7\u5728\u5167\u7684\u4ee3\u8b1d\u6027\u75be\u75c5\u4e2d\u767c\u63ee\u8457\u91cd\u8981\u4f5c\u7528[1]\u3002ASC47\u7684\u8102\u80aa\u9776\u5411\u905e\u9001\u7279\u6027\u4f7f\u5176\u6709\u5225\u65bc\u5176\u4ed6\u4e3b\u8981\u70ba\u809d\u81df\u9776\u5411\u7684THR\u03b2\u9078\u64c7\u6027\u6fc0\u52d5\u5291[2]\u3002<\/p>\n<p>THR\u03b2\u5728\u8102\u80aa\u7d44\u7e54\u548c\u809d\u81df\u7d44\u7e54\u4e2d\u8868\u9054\u90fd\u5f88\u9ad8[3]\u3002\u8981\u5be6\u73fe\u5177\u6709\u81e8\u5e8a\u610f\u7fa9\u7684\u6e1b\u91cd\uff0c\u8102\u80aa\u7d44\u7e54\u4e2d\u9700\u8981\u6709\u9ad8\u6fc3\u5ea6\u7684THR\u03b2\u9078\u64c7\u6027\u6fc0\u52d5\u5291\u3002\u8fd1\u5e74\u4f86\uff0c\u4e00\u4e9bTHR\u03b2\u9078\u64c7\u6027\u6fc0\u52d5\u5291\u901a\u904e\u809d\u81df\u9776\u5411\u7d66\u85e5\u6210\u529f\u5730\u6cbb\u7642\u4e86\u4ee3\u8b1d\u529f\u80fd\u969c\u7919\u76f8\u95dc\u8102\u80aa\u6027\u809d\u708e\uff08MASH\uff0c\u4e00\u7a2e\u809d\u81df\u75be\u75c5\uff09\u3002\u7136\u800c\uff0c\u9019\u4e9bTHR\u03b2\u6fc0\u52d5\u5291\u7f3a\u4e4f\u8102\u80aa\u9776\u5411\u7279\u6027\u3002\u4f8b\u5982\uff0cresmitirom\u5728\u809d\u81df\u7d44\u7e54\u4e2d\u6709\u986f\u8457\u7684\u9ad8\u6fc3\u5ea6\u84c4\u7a4d\uff0c\u4f46\u5728\u5176\u4ed6\u7d44\u7e54\uff08\u5305\u62ec\u8102\u80aa\u7d44\u7e54\uff09\u4e2d\u5e7e\u4e4e\u6c92\u6709\u6216\u5b8c\u5168\u6c92\u6709\u84c4\u7a4d[2]\u3002ASC47\u5177\u6709THR\u03b2\u9078\u64c7\u6027\u548c\u8102\u80aa\u9776\u5411\u905e\u9001\u7279\u6027\u3002ASC47\u53ef\u9776\u5411\u905e\u9001\u81f3\u8102\u80aa\u7d44\u7e54\uff0c\u9019\u4f7f\u5f97\u4f4e\u5291\u91cf\u548c\u81e8\u5e8a\u9069\u7528\u5291\u91cf\u7684ASC47\u61c9\u7528\u65bc\u80a5\u80d6\u75c7\u7684\u6cbb\u7642\u6210\u70ba\u53ef\u80fd\u3002\u00a0<\/p>\n<p>ASC47\u7684\u4f5c\u7528\u6a5f\u5236<\/p>\n<p>\u901a\u904e\u89e3\u5076\u806f\u86cb\u767d-1\uff08uncoupling protein 1\u6216UCP-1\uff09\u4ecb\u5c0e\u8102\u80aa\u7d44\u7e54\u7522\u71b1\u662fASC47\u6e1b\u8102\u4e26\u5be6\u73fe\u6e1b\u91cd\u4e0d\u6e1b\u808c\u7684\u95dc\u9375\u4f5c\u7528\u6a5f\u5236\u4e4b\u4e00\u3002<\/p>\n<p>\u5728\u4e00\u9805DIO\u5c0f\u9f20\u7684\u982d\u5c0d\u982d\u7814\u7a76\u4e2d\uff0c\u572815\u6beb\u514b\/\u516c\u65a4\u548c45\u6beb\u514b\/\u516c\u65a4ASC47\uff08\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u5169\u9031\u4e00\u6b21\uff09\u7684\u81e8\u5e8a\u76f8\u95dc\u5291\u91cf\u4e0b\uff0cASC47\u6cbb\u7642\u7d44\u7684DIO\u5c0f\u9f20\u8102\u80aa\u7d44\u7e54\u4e2dUCP-1\u7684\u8868\u9054\u91cf\u662f\u53f8\u7f8e\u683c\u9b6f\u80bd\u6cbb\u7642\u7d44\u76844\u500d\u3002\u53f8\u7f8e\u683c\u9b6f\u80bd\u6cbb\u7642\u7d44\u7684DIO\u5c0f\u9f20\u8207\u5c0d\u7167\u7d44\u7684\u8102\u80aa\u7d44\u7e54\u4e2d\u7684UCP-1\u8868\u9054\u6c34\u5e73\u57fa\u672c\u76f8\u540c\u3002<\/p>\n<p>\u8a72\u6a5f\u5236\u4f7fASC47\u6709\u5225\u65bc\u57fa\u65bc\u8178\u4fc3\u80f0\u7d20\u7684\u5019\u9078\u85e5\u7269\u4ee5\u53ca\u5176\u4ed6\u6b63\u5728\u81e8\u5e8a\u524d\u548c\u81e8\u5e8a\u958b\u767c\u968e\u6bb5\u7684\u6e1b\u91cd\u4e0d\u6e1b\u808c\u5019\u9078\u85e5\u7269\u3002<\/p>\n<p>ASC47\u8a73\u7d30\u7684\u4f5c\u7528\u6a5f\u5236\u3001\u81e8\u5e8a\u524d\u7642\u6548\u548c\u4e0d\u6e1b\u808c\u6548\u679c\uff0c\u4ee5\u53ca\u5176\u4ed6\u81e8\u5e8a\u524d\u6578\u64da\u9810\u8a08\u5c07\u57282025\u5e74\u7684\u91ab\u5b78\u6703\u8b70\u4e0a\u516c\u4f48\u3002<\/p>\n<p>ASC47\u65bc\u6fb3\u5927\u5229\u4e9e\u958b\u5c55\u7684\u6cbb\u7642\u80a5\u80d6\u75c7I\u671f\u7814\u7a76<\/p>\n<p>1. \u5728LDL-C\u504f\u9ad8\u53d7\u8a66\u8005\u4e2d\u9032\u884c\u7684ASC47\u55ae\u85e5SAD\u7814\u7a76\uff1a\u7814\u7a76\u76ee\u6a19\u5305\u62ec\u7814\u7a76\u5728LDL-C\u504f\u9ad8\u53d7\u8a66\u8005\u4e2d\u901a\u904e\u76ae\u4e0b\u6ce8\u5c04SAD\u7684\u8d85\u9577\u6548ASC47\u55ae\u85e5\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u9776\u5411\u7d50\u5408\u548c\u85e5\u4ee3\u52d5\u529b\u5b78\u3002<\/p>\n<p>2. \u5728\u80a5\u80d6\u75c7\u60a3\u8005\u4e2d\u9032\u884c\u7684ASC47\u55ae\u85e5SAD\u7814\u7a76\uff1a\u7814\u7a76\u76ee\u6a19\u5305\u62ec\u7814\u7a76\u5728\u80a5\u80d6\u75c7\u60a3\u8005\uff08\u9ad4\u91cd\u6307\u6578\uff08BMI\uff09\u572830-40\uff09\u4e2d\u901a\u904e\u76ae\u4e0b\u6ce8\u5c04SAD\u7684\u8d85\u9577\u6548ASC47\u55ae\u85e5\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u85e5\u4ee3\u52d5\u529b\u5b78\u548c\u521d\u6b65\u85e5\u6548\u3002<\/p>\n<p>3. \u5728\u80a5\u80d6\u75c7\u60a3\u8005\u4e2d\u9032\u884c\u7684ASC47\u55ae\u85e5MAD\u7814\u7a76\uff1a\u5728\u80a5\u80d6\u75c7\u60a3\u8005\uff08BMI\u572830-40\uff09\u4e2d\u901a\u904e\u76ae\u4e0b\u6ce8\u5c04MAD\u7684ASC47\uff08\u6bcf\u56db\u9031\u4e00\u6b21\uff0c\u5171\u4e09\u6b21\uff09\u3002\u7814\u7a76\u76ee\u6a19\u5305\u62ec\u8d85\u9577\u6548ASC47\u55ae\u85e5\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u85e5\u4ee3\u52d5\u529b\u5b78\u548c\u521d\u6b65\u85e5\u6548\u3002<\/p>\n<p>4. \u5728\u80a5\u80d6\u75c7\u60a3\u8005\u4e2d\u9032\u884c\u7684ASC47\u806f\u5408\u66ff\u723e\u6cca\u80bd\u6216\u53f8\u7f8e\u683c\u9b6f\u80bdMAD\u7814\u7a76\uff1a\u80a5\u80d6\u75c7\u60a3\u8005\uff08BMI\u572830-40\uff09\u63a5\u53d7ASC47\u8207\u66ff\u723e\u6cca\u80bd\uff08\u6216\u53f8\u7f8e\u683c\u9b6f\u80bd\uff09\u806f\u5408\u7528\u85e5\u6cbb\u7642\u6216\u66ff\u723e\u6cca\u80bd\uff08\u6216\u53f8\u7f8e\u683c\u9b6f\u80bd\uff09\u55ae\u85e5\u6cbb\u7642\u3002ASC47\u7684\u76ae\u4e0b\u6ce8\u5c04\u983b\u7387\u70ba\u6bcf\u56db\u9031\u4e00\u6b21\uff0c\u5171\u4e09\u6b21\u3002\u66ff\u723e\u6cca\u80bd\uff08\u6216\u53f8\u7f8e\u683c\u9b6f\u80bd\uff09\u7684\u76ae\u4e0b\u6ce8\u5c04\u983b\u7387\u70ba\u6bcf\u9031\u4e00\u6b21\uff0c\u5171\u5341\u4e8c\u6b21\u3002\u7814\u7a76\u76ee\u6a19\u5305\u62ecASC47\u8207\u66ff\u723e\u6cca\u80bd\uff08\u6216\u53f8\u7f8e\u683c\u9b6f\u80bd\uff09\u806f\u5408\u7528\u85e5\u6cbb\u7642\u5c0d\u6bd4\u66ff\u723e\u6cca\u80bd\uff08\u6216\u53f8\u7f8e\u683c\u9b6f\u80bd\uff09\u55ae\u85e5\u6cbb\u7642\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u85e5\u4ee3\u52d5\u529b\u5b78\u548c\u521d\u6b65\u85e5\u6548\u3002<\/p>\n<p>\u53c3\u8003\u6587\u737b<\/p>\n<div>\n<p class=\"prnml4\"><span class=\"prnews_span\">1.\u00a0\u00a0\u00a0\u00a0\u00a0 Gilani A, et al. Diabetes. 2024; 73(2), 169-177.<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">2.\u00a0\u00a0\u00a0\u00a0\u00a0 Harrison SA, et al. Lancet 2019; 394: 2012\u201324.<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">3.\u00a0\u00a0\u00a0\u00a0\u00a0 <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/gene\/7068\" target=\"_blank\" class=\"prnews_a\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/gene\/7068<\/a>.<\/span><\/p>\n<\/div>\n<p>\u00a0<\/p>\n<p>\u95dc\u65bc\u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8<\/p>\n<p>\u6b4c\u79ae\u662f\u4e00\u5bb6\u5728\u9999\u6e2f\u8b49\u5238\u4ea4\u6613\u6240\u4e0a\u5e02\uff081672.HK\uff09\u7684\u5275\u65b0\u7814\u767c\u9a45\u52d5\u578b\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u6db5\u84cb\u4e86\u5f9e\u65b0\u85e5\u7814\u767c\u81f3GMP\u751f\u7522\u7684\u5b8c\u6574\u50f9\u503c\u93c8\u3002\u6b4c\u79ae\u7684\u7ba1\u7406\u5718\u968a\u5177\u5099\u6df1\u539a\u7684\u5c08\u696d\u77e5\u8b58\u53ca\u512a\u79c0\u7684\u904e\u5f80\u6210\u5c31\uff0c\u5728\u5718\u968a\u7684\u5e36\u9818\u4e0b\uff0c\u6b4c\u79ae\u5feb\u901f\u63a8\u9032\u85e5\u7269\u7ba1\u7dda\u958b\u767c\uff0c\u805a\u7126\u5169\u5927\u81e8\u5e8a\u9700\u6c42\u5c1a\u672a\u6eff\u8db3\u7684\u91ab\u7642\u9818\u57df\uff1a\u4ee3\u8b1d\u6027\u75be\u75c5\u548c\u75c5\u6bd2\u6027\u75be\u75c5\uff0c\u4e26\u4ee5\u5168\u7403\u5316\u7684\u8996\u91ce\u9032\u884c\u4f48\u5c40\u3002\u6b4c\u79ae\u7684\u7814\u767c\u7ba1\u7dda\u64c1\u6709\u591a\u6b3e\u5728\u7814\u85e5\u7269\u3002<\/p>\n<p>\u6b32\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8acb\u767b\u9304\u7db2\u7ad9\uff1a<a href=\"https:\/\/www.ascletis.com\/\" target=\"_blank\" rel=\"noopener\">www.ascletis.com<\/a>\u3002<\/p>\n<p>\u8a73\u60c5\u5782\u8a62\uff1a<\/p>\n<p><span class=\"xn-person\">Peter Vozzo<\/span><br \/>ICR Healthcare<br \/>443-231-0505 (\u7f8e\u570b)<br \/><a href=\"mailto:Peter.vozzo@westwicke.com\" target=\"_blank\" rel=\"noopener\">Peter.vozzo@westwicke.com<\/a>\u00a0<\/p>\n<p>\u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8PR\u548cIR\u5718\u968a<br \/>+86-181-0650-9129 (\u4e2d\u570b)<br \/><a href=\"mailto:pr@ascletis.com\" target=\"_blank\" rel=\"noopener\">pr@ascletis.com<\/a><br \/><a href=\"mailto:ir@ascletis.com\" target=\"_blank\" rel=\"noopener\">ir@ascletis.com<\/a>\u00a0<\/p>","protected":false},"excerpt":{"rendered":"<p>-\u5728\u6fb3\u5927\u5229\u4e9e\u9032\u884c\u7684\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u81bd\u56fa\u9187\uff08LDL-C\uff09\u504f\u9ad8\u53d7\u8a66\u8005I\u671f\u55ae\u5291\u91cf\u905e\u589e\uff08SAD\uff09\u7814\u7a76\u6578\u64da\u986f\u793a\uff0c\u76ae\u4e0b\u6ce8\u5c04ASC47\u7684\u534a\u8870\u671f\u9577\u905421\u5929\uff0c\u652f\u6301\u5728\u80a5\u80d6\u75c7\u60a3\u8005\u4e2d\u6bcf\u6708\u7d66\u85e5\u4e00\u6b21 -\u5728\u4f7f\u7528\u98f2\u98df\u8a98\u767c\u80a5\u80d6\uff08DIO\uff09\u5c0f\u9f20\u6a21\u578b\u7684\u591a\u9805\u81e8\u5e8a\u524d\u7814\u7a76\u4e2d\uff0cASC47\u986f\u793a\u51fa\u4e86\u5065\u5eb7\u7684\u6e1b\u91cd\u6548\u679c\uff08\u6e1b\u91cd\u4e0d\u6e1b\u808c\uff09 -\u5728\u4e00\u9805\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\uff08semaglutide\uff09\u9032\u884c\u982d\u5c0d\u982d\u6bd4\u8f03\u7684DIO\u5c0f\u9f20\u6a21\u578b\u81e8\u5e8a\u524d\u7814\u7a76\u4e2d\uff0cASC47\u6cbb\u7642\u7d44DIO\u5c0f\u9f20\u7e3d\u9ad4\u8102\u91cf\u6e1b\u5c11\uff08-63.5%\uff09\uff0c\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\uff08-39.6%\uff09\u76f8\u6bd4\uff0c\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u3002\u5728\u540c\u4e00\u9805\u7814\u7a76\u4e2d\uff0cASC47\u6cbb &#8230; <\/p>\n<p class=\"read-more-container\"><a title=\"\u6b4c\u79ae\u5ba3\u4f48\u540c\u985e\u9996\u5275\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u6e1b\u91cd\u4e0d\u6e1b\u808c\u5019\u9078\u85e5\u7269ASC47\u5728\u6fb3\u5927\u5229\u4e9e\u9032\u884c\u7684\u81e8\u5e8aI\u671f\u7814\u7a76\u53d6\u5f97\u7a4d\u6975\u7d50\u679c\" class=\"read-more button\" href=\"https:\/\/www.franchise.com.hk\/zh-hans\/%e6%ad%8c%e7%a6%ae%e5%ae%a3%e4%bd%88%e5%90%8c%e9%a1%9e%e9%a6%96%e5%89%b5%e6%b2%bb%e7%99%82%e8%82%a5%e8%83%96%e7%97%87%e7%9a%84%e6%b8%9b%e9%87%8d%e4%b8%8d%e6%b8%9b%e8%82%8c%e5%80%99%e9%81%b8%e8%97%a5\/23040#more-23040\" aria-label=\"\u66f4\u591a \u6b4c\u79ae\u5ba3\u4f48\u540c\u985e\u9996\u5275\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u6e1b\u91cd\u4e0d\u6e1b\u808c\u5019\u9078\u85e5\u7269ASC47\u5728\u6fb3\u5927\u5229\u4e9e\u9032\u884c\u7684\u81e8\u5e8aI\u671f\u7814\u7a76\u53d6\u5f97\u7a4d\u6975\u7d50\u679c\">\u4e86\u89e3\u8a73\u60c5<\/a><\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_generate-full-width-content":"","spay_email":"","footnotes":""},"categories":[1],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.4 - 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