{"id":19543,"date":"2024-06-07T11:00:00","date_gmt":"2024-06-07T03:00:00","guid":{"rendered":"https:\/\/www.franchise.com.hk\/%e9%a8%b0%e7%9b%9b%e5%8d%9a%e8%97%a5%e5%9c%a82024%e5%b9%b4easl%e5%a4%a7%e6%9c%83%e4%b8%8a%e7%99%bc%e4%bd%88%e5%85%b6%e6%ad%a3%e5%9c%a8%e9%80%b2%e8%a1%8c%e7%9a%84%e6%85%a2%e6%80%a7%e4%b9%99\/19543"},"modified":"2024-06-07T11:00:00","modified_gmt":"2024-06-07T03:00:00","slug":"%e9%a8%b0%e7%9b%9b%e5%8d%9a%e8%97%a5%e5%9c%a82024%e5%b9%b4easl%e5%a4%a7%e6%9c%83%e4%b8%8a%e7%99%bc%e4%bd%88%e5%85%b6%e6%ad%a3%e5%9c%a8%e9%80%b2%e8%a1%8c%e7%9a%84%e6%85%a2%e6%80%a7%e4%b9%99","status":"publish","type":"post","link":"https:\/\/www.franchise.com.hk\/zh-hans\/%e9%a8%b0%e7%9b%9b%e5%8d%9a%e8%97%a5%e5%9c%a82024%e5%b9%b4easl%e5%a4%a7%e6%9c%83%e4%b8%8a%e7%99%bc%e4%bd%88%e5%85%b6%e6%ad%a3%e5%9c%a8%e9%80%b2%e8%a1%8c%e7%9a%84%e6%85%a2%e6%80%a7%e4%b9%99\/19543","title":{"rendered":"\u9a30\u76db\u535a\u85e5\u57282024\u5e74EASL\u2122\u5927\u6703\u4e0a\u767c\u4f48\u5176\u6b63\u5728\u9032\u884c\u7684\u6162\u6027\u4e59\u578b\u809d\u708e2\u671f\u7814\u7a76\u6700\u65b0\u6578\u64da"},"content":{"rendered":"

\u65b0\u7684\u8f49\u5316\u6578\u64da\u8868\u660e\uff0cBRII-179\u8a98\u5c0e\u7684\u514d\u75ab\u61c9\u7b54\u8207\u90e8\u5206\u6162\u6027\u4e59\u578b\u809d\u708e\u75c5\u6bd2 (HBV) \u611f\u67d3\u53d7\u8a66\u8005\u7684\u4e59\u578b\u809d\u708e\u8868\u9762\u6297\u539f (HBsAg)\u5927\u5e45\u4e0b\u964d\u5bc6\u5207\u76f8\u95dc BRII-179\u4f5c\u70ba\u758a\u52a0\u7642\u6cd5\u53ef\u8a98\u5c0e\u529f\u80fd\u6027\u6297\u9ad4\u61c9\u7b54\uff0c\u6709\u52a9\u65bc\u6539\u5584\u63a5\u53d7\u805a\u4e59\u4e8c\u9187\u5e72\u64fe\u7d20\u03b1 (PEG-IFN\u03b1) \u6cbb\u7642\u7684\u6162\u6027HBV\u611f\u67d3\u53d7\u8a66\u8005\u7684HBsAg\u6301\u7e8c\u6e05\u9664 <\/p>\n

\u4e2d\u570b\u5317\u4eac\u548c\u7f8e\u570b\u5317\u5361\u7f85\u840a\u7d0d\u5dde\u9054\u52d2\u59c6\u5e02<\/span>2024\u5e746\u67087\u65e5<\/span> \/\u7f8e\u901a\u793e\/ —\u00a0\u9a30\u76db\u535a\u85e5\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8<\/a>\uff08\u300c\u9a30\u76db\u535a\u85e5\u300d\u3001\u300c\u6211\u5011\u300d\u6216\u300c\u516c\u53f8\u300d\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a2137.HK\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u91dd\u5c0d\u60a3\u8005\u672a\u88ab\u6eff\u8db3\u7684\u9700\u6c42\u4ee5\u53ca\u91cd\u5927\u516c\u5171\u885b\u751f\u6027\u75be\u75c5\u958b\u767c\u5275\u65b0\u7642\u6cd5\u7684\u8de8\u570b\u4f01\u696d\uff0c\u4eca\u5929\u57282024\u5e74\u6b50\u6d32\u809d\u81df\u7814\u7a76\u5354\u6703\uff08EASL\u2122\uff09\u5927\u6703\u4e0a\u767c\u4f48\u4e86\u5169\u98052\u671f\u7814\u7a76\u7684\u65b0\u6578\u64da\uff0c\u9019\u4e9b\u6578\u64da\u8a55\u4f30\u4e86BRII-179\u8207BRII-835\uff08elebsiran\uff09\u806f\u5408\u7642\u6cd5\u6216BRII-179\u4f5c\u70ba\u758a\u52a0\u7642\u6cd5\u806f\u5408PEG-IFN\u03b1\u6cbb\u7642\u6162\u6027HBV\u611f\u67d3\u7684\u6709\u6548\u6027\u3002<\/p>\n

\n<\/div>\n

\u4e00\u98052\u671f\u81e8\u5e8a\u8a66\u9a57\u7684\u53e3\u982d\u5831\u544a<\/a>\u6578\u64da\u986f\u793a\uff0c\u5728\u90e8\u5206\u6162\u6027HBV\u611f\u67d3\u53d7\u8a66\u8005\u4e2d\uff0cBRII-179\u8207BRII-835\uff08elebsiran\uff09\u806f\u5408\u53ef\u8a98\u5c0e\u986f\u8457\u7684HBV\u7279\u7570\u6027B\u7d30\u80de\u548cT\u7d30\u80de\u61c9\u7b54\uff0c\u9019\u4e9b\u61c9\u7b54\u8207\u6297\u75c5\u6bd2\u4f5c\u7528\u76f8\u95dc\u3002\u9019\u9805\u63a2\u7d22\u6027\u8f49\u5316\u7814\u7a76\u8a55\u4f30\u4e86\u6cbb\u7642\u8a98\u5c0e\u7684\u514d\u75ab\u61c9\u7b54\u8207\u6297\u75c5\u6bd2\u6548\u679c\u4e4b\u9593\u7684\u76f8\u95dc\u6027\uff0c\u7d50\u679c\u8868\u660e\uff1a<\/p>\n

\u9776\u5411\u725b\u78fa\u81bd\u9178\u9209\u5354\u540c\u8f49\u904b\u591a\u80bd\uff08NTCP\uff09\u9130\u8fd1\u5340\u57df\u7684Pre-S1\u7279\u7570\u6027T\u7d30\u80de\u61c9\u7b54\u8207\u90e8\u5206\u63a5\u53d7BRII-835\uff08elebsiran\uff09\u548cBRII-179\u6cbb\u7642\u7684\u53d7\u8a66\u8005\u4e2dHBsAg\u7684\u9ad8\u6c34\u5e73\u4e0b\u964d\u6709\u95dc\u3002 \u5728HBsAg\u4e0b\u964d\u6c34\u5e73\u8f03\u9ad8\u7684\u53d7\u8a66\u8005\u4e2d\uff0c\u96e2\u9ad4\u6aa2\u6e2c\u5230Pre-S1\u7279\u7570\u6027Th1\u578b\u7d30\u80de\u56e0\u5b50\uff08IL-2\uff09\uff0c\u800cTh2\u578b\u61c9\u7b54\u8207HBsAg\u964d\u4f4e\u7121\u95dc\u3002 \u5728\u6709HBsAg\u5927\u5e45\u964d\u4f4e\u53ca\u4e59\u578b\u809d\u708e\u75c5\u6bd2\u8868\u9762\u6297\u9ad4\uff08HBsAb\uff09\u5347\u9ad8\u7684\u53d7\u8a66\u8005\u4e2d\uff0cBRII-179\u8a98\u5c0e\u7684\u6297\u9ad4\u6709\u5f37\u6548\u6297HBV\u7684\u4e2d\u548c\u6d3b\u6027\u3002 <\/p>\n

\u675c\u514b-\u65b0\u52a0\u5761\u570b\u7acb\u5927\u5b78\u91ab\u5b78\u9662\u65b0\u8208\u50b3\u67d3\u75c5\u9805\u76ee\u6559\u6388\u3001\u91ab\u5b78\u535a\u58ebAntonio Bertoletti\u8868\u793a\uff1a\u300c\u9019\u9805\u7814\u7a76\u9996\u6b21\u76f4\u63a5\u8b49\u660e\u4e86HBV\u6cbb\u7642\u6027\u75ab\u82d7\u8a98\u5c0e\u7684\u514d\u75ab\u61c9\u7b54\u5728\u90e8\u5206\u6162\u6027HBV\u611f\u67d3\u53d7\u8a66\u8005\u4e2d\u8207HBsAg\u964d\u4f4e\u548c\u75c5\u6bd2\u63a7\u5236\u76f8\u95dc\u3002\u6297\u75c5\u6bd2\u6d3b\u6027\u770b\u4e0a\u53bb\u8207BRII-179\u8a98\u5c0e\u7684\u6297\u4e59\u578b\u809d\u708e\u75c5\u6bd2\u8868\u9762\u6297\u9ad4\u589e\u5f37\u4ee5\u53caPre-S1\u7279\u7570\u6027T\u7d30\u80de\u61c9\u7b54\u6709\u95dc\uff0c\u8b49\u660e\u4e86BRII-179\u53ef\u4ee5\u6253\u7834\u514d\u75ab\u8010\u53d7\uff0c\u5c0d\u75c5\u6bd2\u611f\u67d3\u7684\u6301\u7e8c\u63a7\u5236\u7522\u751f\u5f71\u97ff\u3002\u300d<\/p>\n

\u53e6\u4e00\u98052\u671f\u81e8\u5e8a\u8a66\u9a57\u7684\u6700\u65b0\u7a81\u7834\u58c1\u5831<\/a>\u5c55\u793a\u7684\u6578\u64da\u986f\u793a\uff0c\u8207PEG-IFN\u03b1\u7d44\u76f8\u6bd4\uff0c\u5f9e\u6cbb\u7642\u7d50\u675f\uff08EOT\uff09\u5230\u6838\u7518\uff08\u9178\uff09\u985e\u9006\u8f49\u9304\u9176\u6291\u5236\u5291\uff08NRTI\uff09\u505c\u85e5\u5f8c\u81f3\u5c1124\u5468\uff0c\u5728PEG-IFN\u03b1\u7684\u57fa\u790e\u4e0a\u4f7f\u7528\u6cbb\u7642\u6027\u75ab\u82d7BRII-179\u53ef\u6539\u5584\u7e3d\u9ad4HBsAg\u6e05\u9664\u7387\u3002\u5728114\u540d\u75c5\u6bd2\u6291\u5236\u6162\u6027HBV\u611f\u67d3\u53d7\u8a66\u8005\u4e2d\u9032\u884c\u7684\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u81e8\u5e8a\u8a66\u9a57\u7684\u96a8\u8a2a\u6578\u64da\u986f\u793a\uff1a<\/p>\n

\u5728\u7b26\u5408NRTI\u505c\u85e5\u6a19\u6e96\u4e26\u9032\u5165NRTI\u505c\u85e5\u76e3\u6e2c\u671f\uff08NDMP\uff09\u7684\u53d7\u8a66\u8005\u4e2d\uff0cBRII-179+PEG-IFN\u03b1\u7d44\u4e2d\u4fdd\u6301HBsAg\u6e05\u9664\u7684\u53d7\u8a66\u8005\u767e\u5206\u6bd4\u9ad8\u65bc\u5b89\u6170\u5291+PEG-IFN\u03b1\u7d44\uff08\u5168\u5206\u6790\u96c6[FAS]\u4e2d19.3% vs 12.3%\uff09\u3002\u5f9eEOT\uff08FAS\u4e2d26.3% vs 19.3%\uff09\u5230NRTI\u505c\u85e5\u5f8c\u81f3\u5c1124\u5468\u6216EOT\u5f8c36\u5468\uff08\u5373\u6578\u64da\u622a\u6b62\u65e5\u671f\uff09\uff0cBRII-179+PEG-IFN\u03b1\u7d44\u7684\u7e3d\u9ad4HBsAg\u6e05\u9664\u7387\u6539\u5584\u8da8\u52e2\u6301\u7e8c\u7dad\u6301\u3002NRTI\u505c\u85e5\u7684\u53d7\u8a66\u8005\u5747\u4e0d\u9700\u8981\u63a5\u53d7NRTI\u518d\u6cbb\u7642\u3002 NRTI\u505c\u85e5\u5f8c\u81f3\u5c1124\u5468\u6642\uff0c\u8207\u5b89\u6170\u5291+PEG-IFN\u03b1\u7d44\u76f8\u6bd4\uff0cBRII-179+PEG-IFN\u03b1\u7d44\u4fdd\u6301HBsAg\u6e05\u9664\u7684\u53d7\u8a66\u8005\u4e2dHBsAb \u2265 100 IU\/L\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u66f4\u9ad8\uff08FAS\u4e2d36.4% vs 14.3%\uff09\u3002 \u5728EOT\u6642HBsAb\u6ef4\u5ea6\u2265 100 IU\/L\u7684\u53d7\u8a66\u8005\u4e2d\uff0c\u6c92\u6709\u53d7\u8a66\u8005\u5728\u6578\u64da\u622a\u6b62\u65e5\u671f\u524d\u51fa\u73feHBsAg\u5f9e< 0.05 IU\/mL\uff08LLOQ\uff09\u8b8a\u70ba\u2265 0.05 IU\/mL\uff08\u5373HBsAg\u53cd\u5f48\uff09\u7684\u60c5\u6cc1\uff0c\u9019\u8868\u660e\u5c0dHBV\u7684\u7a69\u5065\u6297\u9ad4\u61c9\u7b54\u662f\u505c\u6b62\u6cbb\u7642\u5f8cHBsAg\u6301\u7e8c\u6e05\u9664\u7684\u5fc5\u8981\u689d\u4ef6\u3002 BRII-179\u548cPEG-IFN\u03b1\u806f\u5408\u7642\u6cd5\u7e3d\u9ad4\u4e0a\u5b89\u5168\u4e14\u53ef\u8010\u53d7\u3002\u5728EOT\u5f8c\u7684\u96a8\u8a2a\u671f\u548cNDMP\u4e2d\u6c92\u6709\u767c\u73fe\u65b0\u7684\u98a8\u96aa\u3002 <\/p>\n

\u9019\u4e9b\u7814\u7a76\u7684\u6709\u5229\u98a8\u96aa-\u7372\u76ca\u7279\u5fb5\u548c\u79d1\u5b78\u6d1e\u898b\u5c07\u9032\u4e00\u6b65\u652f\u6301BRII-179\u806f\u5408\u5176\u4ed6\u7642\u6cd5\uff08\u4f8b\u5982siRNA\u548cPEG-IFN\u03b1\uff09\u4f5c\u70ba\u6162\u6027HBV\u611f\u67d3\u6cbb\u7642\u7684\u95dc\u9375\u7d44\u6210\u90e8\u5206\u4ee5\u5be6\u73fe\u529f\u80fd\u6027\u6cbb\u7652\u76ee\u6a19\u7684\u81e8\u5e8a\u8a55\u4f30\u3002<\/p>\n

\u95dc\u65bcBRII-179 <\/p>\n

BRII-179\u662f\u4e00\u7a2e\u57fa\u65bc\u91cd\u7d44\u86cb\u767d\u8cea\u7684\u65b0\u578bHBV \u514d\u75ab\u6cbb\u7642\u5019\u9078\u85e5\u7269\uff0c\u53ef\u8868\u9054Pre-S1\u3001Pre-S2\u548cS HBV\u8868\u9762\u6297\u539f\uff0c\u65e8\u5728\u8a98\u5c0e\u589e\u5f37\u7684\u548c\u5ee3\u6cdb\u7684B\u7d30\u80de\u548cT\u7d30\u80de\u514d\u75ab\u61c9\u7b54\u3002\u9a30\u76db\u535a\u85e5\u65bc2018\u5e7412\u6708\u5f9eVBI Vaccines, Inc.\uff08\u300cVBI\u300d\uff09\u5f15\u9032BRII-179\uff0c\u4e26\u81ea2023\u5e747\u6708\u8d77\u5c07\u7368\u5bb6\u8a31\u53ef\u64f4\u5c55\u81f3\u5168\u7403\u6b0a\u76ca\u3002<\/p>\n

\u95dc\u65bc BRII-835\uff08Elebsiran\uff09<\/p>\n

BRII-835\uff08elebsiran\uff09\u662f\u4e00\u7a2e\u7d93\u76ae\u4e0b\u6ce8\u5c04\u7d66\u85e5\u7684\u9776\u5411HBV\u7684siRNA\u7814\u7a76\u6027\u85e5\u7269\uff0c\u5177\u6709\u5c0dHBV\u548cHDV\u76f4\u63a5\u6297\u75c5\u6bd2\u6d3b\u6027\u548c\u8a98\u5c0e\u6709\u6548\u514d\u75ab\u61c9\u7b54\u7684\u6f5b\u529b\u3002\u5b83\u662f\u9996\u500b\u9032\u5165\u81e8\u5e8a\u7684\u63a1\u7528\u589e\u5f37\u578b\u7a69\u5b9a\u5316\u5b78+\uff08ESC+\uff09\u6280\u8853\u7684siRNA\uff0c\u53ef\u589e\u5f37\u7a69\u5b9a\u6027\u4e26\u6700\u5927\u7a0b\u5ea6\u5730\u964d\u4f4e\u812b\u9776\u6548\u61c9\uff0c\u5f9e\u800c\u53ef\u63d0\u5347\u6cbb\u7642\u6548\u529b\u3002\u9a30\u76db\u535a\u85e5\u65bc2020\u5e74\u5f9eVir Biotechnology, Inc.\uff08\u300cVir\u300d\uff09\u7372\u5f97\u4e86\u5728\u5927\u4e2d\u83ef\u5730\u5340\u958b\u767c\u548c\u5546\u696d\u5316BRII-835 (elebsiran) \u7684\u5c08\u6709\u6b0a\u3002<\/p>\n

\u95dc\u65bc\u4e59\u578b\u809d\u708e<\/p>\n

\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u662f\u4e16\u754c\u4e0a\u6700\u91cd\u5927\u7684\u611f\u67d3\u6027\u75be\u75c5\u5a01\u8105\u4e4b\u4e00\uff0c\u5168\u7403\u611f\u67d3\u4eba\u6578\u8d85\u904e2.54\u5104\u30021\u6162\u6027HBV\u611f\u67d3\u662f\u809d\u81df\u75be\u75c5\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u6bcf\u5e74\u7d04\u670982\u842c\u4eba\u6b7b\u65bc\u6162\u6027HBV\u611f\u67d3\u7684\u4f75\u767c\u75c7\u30021\u4e2d\u570b\u6162\u6027HBV\u611f\u67d3\u4eba\u6578\u90548,700\u842c\uff0c\u975e\u5e38\u503c\u5f97\u95dc\u6ce8\u30022<\/p>\n

\u95dc\u65bc\u9a30\u76db\u535a\u85e5<\/p>\n

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[1]\u00a0World Health Organization. (April\u00a02024). Global hepatitis report 2024: action for access in low- and middle-income countries. World Health Organization. Retrieved from https:\/\/www.who.int\/publications\/i\/item\/9789240091672<\/a>\u00a0<\/span><\/p>\n

[2] World Health Organization. Hepatitis. World Health Organization. Retrieved from https:\/\/www.who.int\/china\/health-topics\/hepatitis#:~:text=There%20are%2087%20million%20people,living%20with%20chronic%20hepatitis%20C<\/a>.<\/span><\/p>\n<\/div>\n

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