{"id":18354,"date":"2024-04-08T09:12:00","date_gmt":"2024-04-08T01:12:00","guid":{"rendered":"https:\/\/www.franchise.com.hk\/%e4%b8%89%e8%91%89%e8%8d%89%e7%94%9f%e7%89%a9%e5%85%ac%e4%bd%88%e5%85%b6%e4%ba%8c%e5%83%b9rsv%e5%80%99%e9%81%b8%e7%96%ab%e8%8b%97scb-1019-%e2%85%a0%e6%9c%9f%e8%87%a8%e5%ba%8a%e8%a9%a6%e9%a9%97\/18354"},"modified":"2024-04-08T09:12:00","modified_gmt":"2024-04-08T01:12:00","slug":"%e4%b8%89%e8%91%89%e8%8d%89%e7%94%9f%e7%89%a9%e5%85%ac%e4%bd%88%e5%85%b6%e4%ba%8c%e5%83%b9rsv%e5%80%99%e9%81%b8%e7%96%ab%e8%8b%97scb-1019-%e2%85%a0%e6%9c%9f%e8%87%a8%e5%ba%8a%e8%a9%a6%e9%a9%97","status":"publish","type":"post","link":"https:\/\/www.franchise.com.hk\/zh-hans\/%e4%b8%89%e8%91%89%e8%8d%89%e7%94%9f%e7%89%a9%e5%85%ac%e4%bd%88%e5%85%b6%e4%ba%8c%e5%83%b9rsv%e5%80%99%e9%81%b8%e7%96%ab%e8%8b%97scb-1019-%e2%85%a0%e6%9c%9f%e8%87%a8%e5%ba%8a%e8%a9%a6%e9%a9%97\/18354","title":{"rendered":"\u4e09\u8449\u8349\u751f\u7269\u516c\u4f48\u5176\u4e8c\u50f9RSV\u5019\u9078\u75ab\u82d7SCB-1019 \u2160\u671f\u81e8\u5e8a\u8a66\u9a57\u9996\u6279\u5e74\u8f15\u6210\u5e74\u4eba\u7fa4\u7d44\u7372\u5f97\u7a4d\u6975\u521d\u6b65\u6578\u64da"},"content":{"rendered":"<p class=\"prntac\">&#8212; \u4e8c\u50f9RSV\u5019\u9078\u75ab\u82d7SCB-1019\u8a98\u5c0e\u7684RSV-A\u548cRSV-B\u4e2d\u548c\u6ef4\u5ea6\u6c34\u5e73\u986f\u8457\u63d0\u9ad8\uff0c\u5206\u5225\u9054\u5230\u7d04 6,600 IU\/mL\uff08\u63d0\u9ad8 6.4 \u500d\uff09\u548c\u7d04 46,000 IU\/mL\uff08\u63d0\u9ad8 12 \u500d\uff09&#8211;<\/p>\n<p class=\"prntac\">&#8212; \u76ee\u6a19\u8001\u5e74\u4eba\u7fa4\u7d44\u7684\u2160\u671f\u81e8\u5e8a\u8a66\u9a57\u521d\u6b65\u6578\u64da\u5c07\u65bc2024\u5e74\u4e0b\u534a\u5e74\u516c\u5e03 &#8212;<\/p>\n<p><span class=\"legendSpanClass\">\u4e0a\u6d77<\/span><span class=\"legendSpanClass\">2024\u5e744\u67088\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u81f4\u529b\u4ee5\u5275\u65b0\u578b\u75ab\u82d7\u62ef\u6551\u751f\u547d\u548c\u6539\u5584\u5168\u7403\u5065\u5eb7\u6c34\u5e73\u7684\u8655\u65bc\u5546\u696d\u5316\u968e\u6bb5\u7684\u5168\u7403\u751f\u7269\u88fd\u85e5\u516c\u53f8 &#8212; <a href=\"https:\/\/www.cloverbiopharma.com\/cn\/\" target=\"_blank\" rel=\"noopener\">\u4e09\u8449\u8349\u751f\u7269\u88fd\u85e5\u6709\u9650\u516c\u53f8<\/a>\uff08\u4ee5\u4e0b\u7c21\u7a31\u300c\u4e09\u8449\u8349\u751f\u7269\u300d\uff1b\u9999\u6e2f\u806f\u4ea4\u6240\u80a1\u7968\u4ee3\u78bc\uff1a02197\uff09\u4eca\u5929\u516c\u4f48\uff0c\u5728\u8a55\u4f30\u516c\u53f8\u57fa\u65bc\u4e09\u8449\u8349\u751f\u7269\u7368\u6709\u7684Trimer-Tag\uff08\u86cb\u767d\u8cea\u4e09\u805a\u9ad4\u5316\uff09\u75ab\u82d7\u6280\u8853\u5e73\u53f0\u958b\u767c\u7684\u4e8c\u50f9RSV PreF-\u4e09\u805a\u9ad4\u4e9e\u55ae\u4f4d\u5019\u9078\u75ab\u82d7SCB-1019\u7684\u2160\u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d\uff0c\u9996\u6279\u5e74\u8f15\u6210\u5e74\u4eba\u7fa4\u7d44\u7372\u5f97\u4e86\u7a4d\u6975\u7684\u521d\u6b65\u514d\u75ab\u539f\u6027\u548c\u5b89\u5168\u6027\u6578\u64da\u3002<\/p>\n<p>\u300c\u6211\u5011\u5229\u7528\u5df2\u7d93\u9a57\u8b49\u7684Trimer-Tag\u75ab\u82d7\u6280\u8853\u5e73\u53f0\u958b\u767c\u7684\u4e8c\u50f9RSV PreF\u5019\u9078\u75ab\u82d7\u53d6\u5f97\u81e8\u5e8a\u9032\u5c55\uff0c\u7372\u53d6\u4e86\u7a4d\u6975\u7684\u2160\u671f\u81e8\u5e8a\u8a66\u9a57\u521d\u6b65\u7d50\u679c\uff1a\u986f\u793a\u51fa\u91dd\u5c0dRSV-A\u548cRSV-B\u5169\u500b\u75c5\u6bd2\u4e9e\u578b\u5ee3\u8b5c\u4e14\u986f\u8457\u7684\u4e2d\u548c\u6297\u9ad4\u53cd\u61c9\uff0c\u9019\u4ee4\u6211\u5011\u6df1\u53d7\u9f13\u821e\u3002\u300d\u4e09\u8449\u8349\u751f\u7269\u9996\u5e2d\u57f7\u884c\u5b98\u517c\u57f7\u884c\u8463\u4e8b\u6881\u679c\u5148\u751f\u8868\u793a\uff0c\u300cSCB-1019\u662f\u4e2d\u570b\u9996\u6b3eRSV PreF\uff08\u57fa\u65bc\u878d\u5408\u524d\u69cb\u8c61\u7684F\u86cb\u767d\uff09\u5019\u9078\u75ab\u82d7\u4e26\u5df2\u63a8\u9032\u81f3\u81e8\u5e8a\u8a66\u9a57\uff0c\u73fe\u5728\u6211\u5011\u53c8\u7387\u5148\u516c\u4f48\u4e86\u7a4d\u6975\u7684\u81e8\u5e8a\u8a66\u9a57\u521d\u6b65\u6578\u64da\uff0c\u6309\u8a08\u5283\u63a8\u9032\uff0c2024 \u5e74\u4e0b\u534a\u5e74\uff0c\u6211\u5011\u4e5f\u671f\u5f85\u5728\u9996\u6279\u76ee\u6a19\u8001\u5e74\u4eba\u7fa4\u7d44\u4e2d\u7372\u5f97\u66f4\u591a\u7a4d\u6975\u7684\u2160\u671f\u81e8\u5e8a\u8a66\u9a57\u6578\u64da\u3002\u300d<\/p>\n<p>\u2160\u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d\uff0c\u5728\u9996\u6279\u5e74\u8f15\u6210\u5e74\u4eba\u7fa4\u7d44\uff0818-59\u6b72\uff09\u4e2d\u5206\u5225\u63a5\u7a2eSCB-1019\u6216\u751f\u7406\u9e7d\u6c34\u5b89\u6170\u5291\uff0c\u7b2c0\u5929\uff08\u63a5\u7a2e\u524d\uff09\u548c\u7b2c28\u5929\uff08\u63a5\u7a2e\u5f8c\uff09\u4e2d\u548c\u6297\u9ad4\u7684\u5e7e\u4f55\u5e73\u5747\u6ef4\u5ea6 (GMTs) \u548c\u5e7e\u4f55\u500d\u6578\u5347\u9ad8 (GMFRs) \u7684\u521d\u6b65\u7d50\u679c\u986f\u793a\u5982\u4e0b\uff1a<\/p>\n<div>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">RSV A \u4e2d\u548c\u6297\u9ad4<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">RSV B \u4e2d\u548c\u6297\u9ad4<\/span><\/p>\n<p>     <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">SCB-1019<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(n=8)<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">GMT (0\u5929)\u00a0:\u00a0 \u00a0 \u00a0 1,032 IU\/mL<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">GMT (28\u5929):\u00a0 \u00a0 \u00a06,648 IU\/mL<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">GMFR:\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u63d0\u9ad86.4\u500d<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">GMT (0\u5929)\u00a0:\u00a0 \u00a0 \u00a03,950 IU\/mL\u00a0\u00a0<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">GMT (28\u5929):\u00a0 \u00a0 46,674 IU\/mL\u00a0<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">GMFR:\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u63d0\u9ad811.8\u500d \u00a0<\/span><\/p>\n<p>     <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u5b89\u6170\u5291\u00a0<br \/>\u751f\u7406\u9e7d\u6c34<br \/>(n=4)<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">GMT (0\u5929) :\u00a0 \u00a0 \u00a0 415 IU\/mL<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">GMT (28\u5929):\u00a0 \u00a0 \u00a0415 IU\/mL<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">GMFR:\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u7121\u660e\u986f\u8b8a\u5316<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">GMT (0\u5929):\u00a0 \u00a0 \u00a0 3,783 IU\/mL<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">GMT (28\u5929):\u00a0 \u00a0 4,498 IU\/mL<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">GMFR:\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u7121\u660e\u986f\u8b8a\u5316<\/span><\/p>\n<p>     <\/p>\n<\/div>\n<p>\u00a0<\/p>\n<p>\u672c\u7814\u7a76\u4e2d\u7684RSV-A\u548cRSV-B\u4e2d\u548c\u6aa2\u6e2c\u65bc\u7b2c\u4e09\u65b9\u6aa2\u6e2c\u5be6\u9a57\u5ba4\u9032\u884c\uff0c\u4f7f\u7528\u7684\u662f\u7d93\u904e\u9a57\u8b49\u7684\u81e8\u5e8a\u6aa2\u6e2c\u65b9\u6cd5\u548cNIBSC 16\/284\u53c3\u8003\u6a19\u6e96\u8840\u6e05\uff0c\u6aa2\u6e2c\u503c\u4ee5\u6bcf\u6beb\u5347\u570b\u969b\u55ae\u4f4d (IU\/mL) \u8868\u793a\u3002<\/p>\n<p>\u8207\u5176\u4ed6\u86cb\u767d\u4e9e\u55ae\u4f4dRSV PreF\u75ab\u82d7\u76f8\u6bd4\uff0c\u4e09\u8449\u8349\u751f\u7269\u81ea\u7814\u7684RSV\u5019\u9078\u75ab\u82d7SCB-1019\u91dd\u5c0dRSV-A\u548cRSV-B\u4e2d\u548c\u6297\u9ad4\u7684\u521d\u6b65\u514d\u75ab\u539f\u6027\u6578\u64da\u8f03\u4e4b\u76f8\u7576\u6216\u53ef\u80fd\u66f4\u512a<span>[1, 2, 3]<\/span>\uff0c\u540c\u6642\uff0c\u9019\u4e9b\u7a4d\u6975\u7684\u514d\u75ab\u539f\u6027\u6578\u64da\u9032\u4e00\u6b65\u652f\u6301\u4e09\u8449\u8349\u751f\u7269\u9078\u64c7\u958b\u767c\u4e8c\u50f9RSV-A\/B PreF\u75ab\u82d7\u7684\u7b56\u7565\uff0c\u56e0\u70ba\u66fe\u6709\u6578\u64da\u8b49\u5be6\u5176\u4ed6\u53ea\u91dd\u5c0dRSV-A\u4e9e\u578b\u7684\u55ae\u50f9\u75ab\u82d7\u5c0dRSV-B\u4e9e\u578b\u7684\u514d\u75ab\u53cd\u61c9\u548c\/\u6216\u4fdd\u8b77\u6548\u529b\u8f03\u4f4e<span>[1, 4, 5<\/span>]\u3002\u9019\u6b21\u81e8\u5e8a\u7d50\u679c\u9084\u8b49\u5be6\u4e86\u4e09\u8449\u8349\u751f\u7269\u7684SCB-1019\u7684PreF\u6297\u539f\u4fdd\u6301\u4e86\u7a69\u5b9a\u7684\u878d\u5408\u524d\u548c\u4e09\u805a\u9ad4\u7684\u7d50\u69cb\uff0c\u4e14\u63a2\u7d22\u6027\u514d\u75ab\u539f\u6027\u7d50\u679c\u986f\u793a\u51fa\u7684\u5728\u4e2d\u548c\u4f4d\u9ede\u00d8\u7af6\u722d\u6027\u6297\u9ad4\u6ef4\u5ea6\u986f\u8457\u589e\u52a0\uff0c\u4e5f\u9032\u4e00\u6b65\u8b49\u5be6\u4e86\u9019\u4e00\u9ede\u3002\u6b64\u5916\uff0c\u5728\u9996\u6279\u5e74\u8f15\u6210\u5e74\u4eba\u7fa4\u7d44\u63a5\u7a2eSCB-1019\u7684\u53d7\u8a66\u8005\u6c92\u6709\u89c0\u5bdf\u5230\u4efb\u4f55\u660e\u986f\u7684\u5b89\u5168\u6027\u6216\u53cd\u61c9\u539f\u6027\u554f\u984c\uff0c\u7e7c\u6b64\uff0c\u8a08\u5283\u4e2d\u7684\u8001\u5e74\u4eba\u7fa4\u5165\u7d44\u2160\u671f\u81e8\u5e8a\u8a66\u9a57\u4e5f\u5df2\u9806\u5229\u5982\u671f\u63a8\u9032\u3002<\/p>\n<p>\u5728\u6fb3\u5927\u5229\u4e9e\u9032\u884c\u7684\u2160\u671f\u81e8\u5e8a\u8a66\u9a57\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u5b89\u6170\u5291\u5c0d\u7167\u7814\u7a76\uff0c\u76ee\u7684\u662f\u8a55\u4f30SCB-1019\u5728\u5e74\u8f15\u6210\u5e74\u4eba\u548c\u8001\u5e74\u4eba\u7fa4\u4e2d\u4e0d\u540c\u5291\u578b\u3001\u4e0d\u540c\u5291\u91cf\u6c34\u5e73\u4e0b\u7684\u5b89\u5168\u6027\u3001\u53cd\u61c9\u539f\u6027\u548c\u514d\u75ab\u539f\u6027\u3002\u8001\u5e74\u4eba\u7fa4\u7d44\u7684\u5b89\u5168\u6027\u548c\u514d\u75ab\u539f\u6027\u7d50\u679c\u9810\u8a08\u65bc2024\u5e74\u4e0b\u534a\u5e74\u516c\u4f48\u3002\u00a0<\/p>\n<div>\n<p class=\"prnml4\"><span class=\"prnews_span\">[1] Icosavax Company Presentations (28-JUN-2022 &amp; 22-MAY-2023) and Press Release (12-DEC-2023)<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">[2] NIH DS-Cav1 (DOI: 10.1016\/S2213-2600(21)00098-9)<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">[3] Pfizer (DOI: 10.1093\/infdis\/jiab612)<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">[4] GSK ACIP Presentation (21-JUN-2023)<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">[5] Moderna ACIP Presentation 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