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2023\u5e74\uff0c\u516c\u53f8\u5728\u5176\u91cd\u9ede\u7684\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u9805\u76ee\u4e2d\u53d6\u5f97\u4e86\u91cd\u8981\u91cc\u7a0b\u7891\uff0c\u63a8\u52d5\u4e86HBV\u529f\u80fd\u6027\u6cbb\u7652\u65b0\u578b\u806f\u5408\u7642\u6cd5\u7684\u958b\u767c\uff0c\u540c\u6642\u62d3\u5c55\u4e86\u7522\u54c1\u7d44\u5408\u3002\u96a8\u8457\u6b63\u5728\u9032\u884c\u7684\u591a\u500bHBV\u5019\u9078\u85e5\u7269\u81e8\u5e8a\u8a66\u9a57\u7522\u751f\u5f62\u6210\u6027\u6578\u64da\uff0c\u4ee5\u53ca\u7372\u5f97\u4e86BRII-179\u7684\u5168\u7403\u77e5\u8b58\u7522\u6b0a\u548c\u751f\u7522\u6280\u8853\uff0c\u516c\u53f8\u5c07\u57282024\u5e74\u555f\u52d5\u591a\u9805\u806f\u5408\u7642\u6cd5\u7684\u7814\u7a76\u3002<\/p>\n

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2023\u8ca1\u5e74\u53ca\u8fd1\u671f\u516c\u53f8\u9032\u5c55<\/p>\n

2024\u5e742\u6708\uff0c\u9a30\u76db\u535a\u85e5\u8207VBI Vaccines, Inc.\uff08\u300cVBI\u300d\uff0c\u7d0d\u65af\u9054\u514b\u80a1\u7968\u4ee3\u78bc\uff1aVBIV\uff09\u9054\u6210\u5354\u8b70\uff0c\u6536\u8cfc BRII-179\u7684\u5168\u7403\u77e5\u8b58\u7522\u6b0a\u548c\u751f\u7522\u6280\u8853\uff0c\u4ee5\u64f4\u5927\u5176\u672a\u4f86\u7684\u5168\u7403\u751f\u7522\u548c\u4f9b\u61c9\u80fd\u529b\u3002\u540c\u6642\u9084\u53d6\u6d88\u4e86\u672a\u4f86\u5411VBI\u652f\u4ed8\u7684\u8207BRII-179\u548cPreHevbriTM\u76f8\u95dc\u7684\u8cbb\u7528\u3002 BRII-179\u65bc2023\u5e7411\u6708\u7372\u5f97\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u9812\u767c\u7684\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\uff08BTD\uff09\uff0c\u52a0\u5feb\u70baHBV\u60a3\u8005\u63d0\u4f9b\u5275\u65b0\u7642\u6cd5\u3002 \u9a30\u76db\u535a\u85e5\u65bc2023\u5e747\u6708\u7372\u5f97PreHevbriTM\u5728\u5927\u4e2d\u83ef\u5340\u548c\u4e9e\u592a\u5730\u5340\uff08\u65e5\u672c\u9664\u5916\uff09\u7684\u7368\u5bb6\u958b\u767c\u548c\u5546\u696d\u5316\u6b0a\u76ca\uff0c\u4e26\u5df2\u5c31PreHevbriTM\u5728\u4e2d\u570b\u7684\u8a3b\u518a\u8a08\u5283\u5411CDE\u63d0\u4ea4\u4e86\u5169\u9805<\/span>\u81e8\u5e8a\u524d\u7533\u8acb\uff08pre-IND\uff09\u3002\u9999\u6e2f\u7684\u4e0a\u5e02\u8a3b\u518a\u7533\u8acb\u4e5f\u5df2\u63d0\u4ea4\u3002 \u9a30\u76db\u535a\u85e5\u5df2\u512a\u5316\u5176\u8cc7\u6e90\uff0c\u91cd\u9ede\u6295\u5165\u5176\u9818\u5148\u7684HBV\u7522\u54c1\u7d44\u5408\u7684\u81e8\u5e8a\u548c\u5546\u696d\u958b\u767c\u4e2d\u3002\u516c\u53f8\u6b63\u7a4d\u6975\u5c0b\u6c42\u5408\u4f5c\u6a5f\u6703\uff0c\u4ee5\u9032\u4e00\u6b65\u958b\u767c\u5176\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\uff08CNS\uff09\u3001\u4eba\u985e\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2\uff08HIV\uff09\u548c\u591a\u91cd\u8010\u85e5\u548c\u5ee3\u6cdb\u8010\u85e5\uff08MDR\/XDR\uff09\u9818\u57df\u64c1\u6709\u5168\u7403\u6b0a\u76ca\u7684\u7ba1\u7dda\u3002 \u9a30\u76db\u535a\u85e5\u4efb\u547dBrian A. Johns\u535a\u58eb\u70ba\u9996\u5e2d\u79d1\u5b78\u5b98\uff0c\u8ca0\u8cac\u9a30\u76db\u535a\u85e5\u7684\u65e9\u671f\u767c\u73fe\u9805\u76ee\uff0c\u4e26\u5236\u5b9a\u516c\u53f8\u672a\u4f86\u7684\u7ba1\u7dda\u6230\u7565\u3002\u6211\u5011\u7684\u65b0\u7d44\u7e54\u6230\u7565\u7531\u5728\u611f\u67d3\u6027\u75be\u75c5\u9818\u57df\u64c1\u6709\u8c50\u5bcc\u7d93\u9a57\u7684\u9818\u5c0e\u8005\u6240\u5f15\u9818\uff0c\u4ee5\u78ba\u4fdd\u516c\u53f8\u7ba1\u7dda\u76ee\u6a19\u7684\u9054\u6210\u3002 <\/p>\n

2023\u8ca1\u5e74\u81e8\u5e8a\u7ba1\u7dda\u4eae\u9ede\u548c\u672a\u4f86\u91cc\u7a0b\u7891<\/p>\n

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BRII-179 \u76f8\u95dc\u7814\u7a76\u548c\u8a08\u5283
\n\u5728 2023 \u5e74 11 \u6708\u8209\u884c\u7684\u7f8e\u570b\u809d\u75c5\u7814\u7a76\u5354\u6703\u5e74\u6703\uff08AASLD\uff09\u4e0a\uff0c\u9a30\u76db\u535a\u85e5\u5c55\u793a\u4e86\u5169\u4efd\u95dc\u65bcBRII-179\u7684\u7a81\u7834\u6027\u58c1\u5831\uff0c\u63ed\u793a\u4e86HBsAg\u6e05\u9664\u7387\u8207\u4e59\u809d\u8868\u9762\u6297\u9ad4\u53cd\u61c9\u4e4b\u9593\u7684\u91cd\u8981\u806f\u7e6b\u3002\u9019\u4e9b\u6578\u64da\u70ba\u9032\u4e00\u6b65\u63d0\u9ad8\u529f\u80fd\u6027\u6cbb\u7652\u7387\u548c\u8b58\u5225\u6700\u6709\u53ef\u80fd\u5c0d\u6cbb\u7652\u6027\u7642\u6cd5\u7522\u751f\u61c9\u7b54\u7684\u60a3\u8005\u6307\u660e\u4e86\u65b9\u5411\u3002
\nBRII-179\u53ef\u8a98\u5c0e\u529f\u80fd\u6027\u514d\u75ab\u61c9\u7b54\uff0c\u63d0\u9ad8\u63a5\u53d7\u806f\u5408\u805a\u4e59\u4e8c\u9187\u5e72\u64fe\u7d20\u03b1\uff08PEG-IFN\u03b1\uff09\u6cbb\u7642\u7684\u6162\u4e59\u809d\u60a3\u8005\u7684HBsAg\u6e05\u9664\u7387\u548c\u6e05\u9664\u6301\u7e8c\u6642\u9593\uff0c\u9032\u800c\u53ef\u80fd\u63d0\u9ad8\u6162\u4e59\u809d\u60a3\u8005\u529f\u80fd\u6027\u6cbb\u7652\u7387\u3002 \u9a30\u76db\u535a\u85e5\u5c0dBRII-179\u548cBRII-179\u806f\u5408BRII-835\uff08elebsiran\uff09\u958b\u5c55\u76841b\/2a\u671f\u7814\u7a76\u7684\u8f49\u5316\u7814\u7a76\u6578\u64da\u8868\u660e\uff0cBRII-179\u53ef\u80fd\u6709\u52a9\u65bc\u8b58\u5225\u51fa\u80fd\u5920\u7522\u751f\u5fc5\u8981HBV\u7279\u7570\u6027\u514d\u75ab\u61c9\u7b54\u7684\u6162\u4e59\u809d\u60a3\u8005\uff0c\u5f9e\u800c\u5728\u9019\u4e9b\u88ab\u7be9\u9078\u51fa\u7684\u60a3\u8005\u4e2d\u5be6\u73fe\u66f4\u9ad8\u7684\u529f\u80fd\u6027\u6cbb\u7652\u7387\uff0c\u540c\u6642\u907f\u514d\u4e86\u5176\u4ed6\u60a3\u8005\u63a5\u53d7\u4e0d\u5fc5\u8981\u7684\u6cbb\u7642\u3002
\n \u9a30\u76db\u535a\u85e5\u8a08\u5283\u57282024\u5e74\u4e0b\u534a\u5e74\u555f\u52d5\u591a\u9805\u806f\u5408\u7814\u7a76\uff0c\u4ee5\u9a57\u8b49BRII-179\u8207\u5176\u4ed6\u7642\u6cd5\u806f\u5408\u4f7f\u7528\u6642\u63d0\u9ad8HBV\u529f\u80fd\u6027\u6cbb\u7652\u7387\u7684\u80fd\u529b\u3002 \u9a30\u76db\u535a\u85e5\u5c07\u57282024\u5e743\u670827\u65e5\u81f331\u65e5\u65bc\u65e5\u672c\u4eac\u90fd\u8209\u884c\u7684\u7b2c33\u5c46\u4e9e\u592a\u809d\u81df\u7814\u7a76\u5b78\u6703\uff08APASL\uff09\u6703\u8b70\u4e0a\uff0c\u4ee5\u7a81\u7834\u6027\u53e3\u982d\u5831\u544a\u7684\u5f62\u5f0f\u516c\u4f48\u5176\u6b63\u5728\u9032\u884c\u7684BRII-179\u806f\u5408PEG-IFN\u03b1\u6cbb\u7642\u6162\u4e59\u809d\u60a3\u8005\u7684 2 \u671f\u7814\u7a76\u4e2d\uff0c\u7b26\u5408\u6838\u7518\u9178\u9006\u8f49\u9304\u9176\u6291\u5236\u5291\uff08NRTI\uff09\u505c\u85e5\u6a19\u6e96\u7684\u60a3\u8005\u6578\u64da\u3002 <\/p>\n

BRII-835\uff08Elebsiran\uff09& BRII-877\uff08Tobevibart\uff09\u76f8\u95dc\u7814\u7a76\u548c\u8a08\u5283
\n\u5df2\u5b8c\u6210\u5728\u5305\u62ec\u4e2d\u570b\u5927\u9678\u5728\u5167\u7684\u4e9e\u592a\u5730\u5340\u958b\u5c55\u7684BRII-835\uff08elebsiran\uff09\u806f\u5408PEG-IFN\u03b1\u76842\u671f\u7814\u7a76\u60a3\u8005\u5165\u7d44\u5de5\u4f5c\u3002\u8a72\u7814\u7a76\u65e8\u5728\u9032\u4e00\u6b65\u77ad\u89e3BRII-835\uff08elebsiran\uff09\u76f8\u8f03\u55ae\u7528PEG-IFN\u03b1\u5c0d\u63d0\u9ad8HBV\u6cbb\u7652\u7387\u65b9\u9762\u7684\u6548\u679c\uff0c\u4e26\u63a2\u7d22BRII-179\u5728\u7be9\u9078\u51fa\u5408\u9069\u7684\u60a3\u8005\u4ee5\u7372\u5f97\u66f4\u4f73\u7642\u6548\u65b9\u9762\u7684\u6f5b\u529b\u3002\u8a72\u7814\u7a76\u7684\u521d\u6b65\u9802\u7dda\u7d50\u679c\u9810\u8a08\u5c07\u65bc2024\u5e74\u7b2c\u56db\u5b63\u5ea6\u516c\u4f48\u3002 \u9a30\u76db\u535a\u85e5\u7684\u5408\u4f5c\u5925\u4f34Vir Biotechnology, Inc.\uff08\u300cVir\u300d\uff0c\u7d0d\u65af\u9054\u514b\u80a1\u7968\u4ee3\u78bc\uff1aVIR\uff09\u57282023\u5e7411\u6708\u7684AASLD\u6703\u8b70\u4e0a\u5c55\u793a\u4e86MARCH\u7814\u7a76B\u90e8\u5206\u7684\u65b0\u6578\u64da\u3002\u6578\u64da\u986f\u793a\uff0c\u5728\u5c07BRII-877\uff08tobevibart\uff09\u52a0\u5165\u806f\u5408\u6216\u4e0d\u806f\u5408PEG-IFN\u03b1\u7684BRII-835\uff08elebsiran\uff09\u65b9\u6848\u4e2d\u6cbb\u764224\u5468\u5f8c\uff0c\u61c9\u7b54\u7387\u63d0\u9ad8\u4e86\u7d04\u4e09\u500d\uff1a BRII-877\uff08tobevibart\uff09+ BRII-835\uff08elebsiran\uff09+ PEG-IFN\u03b1\u7684\u61c9\u7b54\u7387\u70ba15.0%\uff0cBRII-877\uff08tobevibart\uff09+ BRII-835\uff08elebsiran\uff09\u7684\u61c9\u7b54\u7387\u70ba14.3%\u3002\u6cbb\u764248\u5468\u7684\u968a\u5217\u6578\u64da\u5c07\u65bc2024\u5e74\u7b2c\u56db\u5b63\u5ea6\u516c\u4f48\u3002 Vir\u57282023\u5e7411\u6708AASLD\u6703\u8b70\u7684\u7a81\u7834\u6027\u5831\u544a\u4e2d\uff0c\u4ee5\u53ca\u57282024\u5e741\u6708\u7b2c42\u5c46\u6469\u6839\u5927\u901a\u91ab\u7642\u5065\u5eb7\u5e74\u6703\u4e0a\uff0c\u5206\u4eab\u4e86SOLSTICE\u7814\u7a76\u4e2d\u4e00\u5c0f\u90e8\u5206\u6162\u6027\u4e01\u578b\u809d\u708e\uff08CHD\uff09\u53c3\u8207\u8005\u7684\u521d\u6b65\u6578\u64da\u3002\u7d93\u904e12\u5468\u7684BRII-877\uff08tobevibart\uff09\u548cBRII-835\uff08elebsiran\uff09\u806f\u5408\u6cbb\u7642\u5f8c\uff0c6\u540d\u53c3\u8207\u8005\u4e2d\u67095\u4eba\u7121\u6cd5\u6aa2\u6e2c\u5230\u4e01\u578b\u809d\u708e\u75c5\u6bd2\u6838\u7cd6\u6838\u9178\uff08HDV RNA\uff09\uff0c6\u540d\u53c3\u8207\u8005\u4e2d\u67096\u4eba\u7684HDV RNA\u4f4e\u65bc\u5b9a\u91cf\u4e0b\u9650\u3002\u5176\u4ed6\u6578\u64da\u5c07\u65bc2024\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u516c\u4f48\uff0c\u5b8c\u6574\u768424\u5468\u6cbb\u7642\u6578\u64da\u9810\u8a08\u5c07\u65bc2024\u5e74\u7b2c\u56db\u5b63\u5ea6\u516c\u4f48\u3002 BRII-877\uff08tobevibart\uff09\u7684\u4e00\u98051\u671f\u7814\u7a76\u6b63\u5728\u4e2d\u570b\u958b\u5c55\u3002\u4e2d\u570b\u5927\u9678\u53d7\u8a66\u8005\u7684\u4eba\u9ad4\u85e5\u4ee3\u52d5\u529b\u5b78\uff08PK\uff09\u6578\u64da\u5c07\u8207\u4e9e\u592a\u5730\u5340\u548c\u6b50\u6d32\u7684\u53d7\u8a66\u8005\u9032\u884c\u6bd4\u8f03\u3002 <\/p>\n

\u5176\u4ed6\u81e8\u5e8a\u548c\u81e8\u5e8a\u524d\u958b\u767c\u66f4\u65b0<\/p>\n

\u57fa\u65bc\u516c\u53f8\u6240\u5c08\u6ce8\u7684HBV\u9805\u76ee\u6230\u7565\uff0c\u9a30\u76db\u535a\u85e5\u6b63\u5c0b\u6c42\u4ee5\u4e0b\u9805\u76ee\u5f8c\u7e8c\u958b\u767c\u7684\u5408\u4f5c\u6a5f\u6703\u3002<\/p>\n

\u591a\u91cd\u8010\u85e5\u548c\u5ee3\u6cdb\u8010\u85e5\uff08MDR\/XDR\uff09\u9769\u862d\u6c0f\u9670\u6027\u83cc\u611f\u67d3\u9805\u76ee<\/p>\n

BRII-693
\n\u9a30\u76db\u535a\u85e5\u65bc2023\u5e746\u6708\u7372\u5f97\u4e86\u958b\u767c\u548c\u5546\u696d\u5316BRII-693\u7684\u5168\u7403\u7368\u5bb6\u6b0a\u76ca\uff0cBRII-693\u662f\u4e00\u7a2e\u65b0\u578b\u591a\u7c98\u83cc\u7d20\uff0c\u7528\u65bc\u6cbb\u7642\u56b4\u91cd\u7684\u9769\u862d\u6c0f\u9670\u6027\u611f\u67d3\u3002\u516c\u53f8\u6b63\u5c0b\u6c42\u6230\u7565\u8cc7\u91d1\u5408\u4f5c\u5925\u4f34\uff0c\u4ee5\u52a0\u5febBRII-693\u7684\u958b\u767c\uff0c\u9019\u7a2e\u65b0\u578b\u6297\u751f\u7d20\u65e8\u5728\u5e6b\u52a9\u61c9\u5c0d\u5168\u7403\u65e5\u76ca\u56b4\u5cfb\u7684\u6297\u83cc\u85e5\u8010\u85e5\u5a01\u8105\u3002 2023\u5e744\u6708\uff0c\u9a30\u76db\u535a\u85e5\u5411NMPA\u63d0\u4ea4\u4e86BRII-693\u7684pre-IND\u7533\u8acb\uff0c\u8a08\u5283\u5728\u4e2d\u570b\u555f\u52d51\u671f\u81e8\u5e8aPK\u6a4b\u63a5\u7814\u7a76\u3002\u516c\u53f8\u6b63\u8a08\u5283\u958b\u5c55\u66f4\u591aPK\u81e8\u5e8a\u7814\u7a76\uff0c\u4ee5\u652f\u63013\u671f\u81e8\u5e8a\u8a66\u9a57\u7684\u555f\u52d5\u3002\u9019\u4e9b\u7814\u7a76\u5c0d\u652f\u6301\u5168\u7403\u958b\u767c\u5de5\u4f5c\u81f3\u95dc\u91cd\u8981\u3002\u91dd\u5c0d\u91ab\u9662\u7372\u5f97\u6027\u7d30\u83cc\u6027\u80ba\u708e\uff08HABP\uff09\/\u547c\u5438\u6a5f\u76f8\u95dc\u7d30\u83cc\u6027\u80ba\u708e\uff08VABP\uff09\u7684\u5927\u578b\u5168\u74033\u671f\u8a3b\u518a\u6027\u81e8\u5e8a\u8a66\u9a57\u9810\u8a08\u5c07\u65bc2025\u5e74\u958b\u5c55\u3002 <\/p>\n

\u4eba\u985e\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2\uff08HIV\uff09\u9805\u76ee<\/p>\n

BRII-753\u662f\u516c\u53f8\u5167\u90e8\u7814\u767c\u7684\u65b0\u5316\u5b78\u5be6\u9ad4\uff0c\u76ee\u524d\u6b63\u8655\u65bc\u81e8\u5e8a\u524d\u958b\u767c\u968e\u6bb5\u3002BRII-753\u662f\u4e00\u7a2e\u9577\u6548\u76ae\u4e0b\u6ce8\u5c04\u5291\uff0c\u53ef\u6bcf\u6708\u4e00\u6b21\u3001\u6bcf\u5b63\u5ea6\u4e00\u6b21\u6216\u6bcf\u5e74\u5169\u6b21\u7d66\u85e5\uff0c\u53ef\u7528\u65bc\u6cbb\u7642HIV\u7684\u806f\u5408\u7642\u6cd5\u548c\u66b4\u9732\u524d\u9810\u9632\u7684\u55ae\u85e5\u7642\u6cd5\u3002
\nBRII-732\u5df2\u5b8c\u62101\u671f\u7814\u7a76\uff0c\u6709\u6f5b\u529b\u958b\u767c\u70baHIV\u60a3\u8005\u6bcf\u9031\u53e3\u670d\u4e00\u6b21\u7684\u9577\u6548\u806f\u5408\u6cbb\u7642\u65b9\u6848\u7684\u4e00\u90e8\u5206\u3002 <\/p>\n

\u975e\u7d50\u6838\u5206\u679d\u687f\u83cc\uff08NTM\uff09\u80ba\u75c5\u9805\u76ee<\/p>\n

BRII-658\uff08Epetraborole\uff09\uff1a2024\u5e742\u6708\uff0c\u9a30\u76db\u535a\u85e5\u7684\u5408\u4f5c\u5925\u4f34AN2 Therapeutics, Inc.\uff08\u7d0d\u65af\u9054\u514b\u80a1\u7968\u4ee3\u78bc\uff1aANTX\uff09\u5ba3\u4f48\u81ea\u9858\u66ab\u505c\u5176epetraborole\uff08BRII-658\uff09\u6cbb\u7642\u96e3\u6cbb\u6027\u5fa9\u5408\u5206\u679d\u687f\u83cc\uff08MAC\uff09\u80ba\u75c5\u76842\/3 \u671f\u81e8\u5e8a\u8a66\u9a57\u60a3\u8005\u62db\u52df\uff0c\u4ee5\u5f85\u9032\u4e00\u6b65\u7684\u6578\u64da\u5be9\u67e5\u3002 <\/p>\n

\u7522\u5f8c\u6291\u9b31\u75c7\uff08PPD\uff09\u548c\u91cd\u5ea6\u6291\u9b31\u75c7\uff08MDD\uff09\u9805\u76ee<\/p>\n

BRII-296\uff1a2023\u5e749 \u6708\uff0c\u8a55\u4f30BRII-296\u76842\u671f\u7814\u7a76\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u7d66\u85e5\u3002BRII-296\u662f\u4e00\u7a2e\u9577\u6548\u6ce8\u5c04\u5291\uff0c\u6b63\u5728\u958b\u767c\u7528\u65bc\u6cbb\u7642PPD\u3002\u516c\u53f8\u9810\u8a08\u5c07\u65bc2024\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u516c\u4f482\u671f\u8a66\u9a57\u6578\u64da\u3002
\nBRII-297\u662f\u4e00\u7a2e\u9577\u6548\u6ce8\u5c04\u5291\uff0c\u6b63\u5728\u958b\u767c\u7528\u65bc\u6cbb\u7642\u7126\u616e\u75c7\u548c\u6291\u9b31\u75c7\uff0c\u8a72\u85e5\u76841\u671f\u81e8\u5e8a\u8a66\u9a57\u5df2\u5b8c\u6210\u60a3\u8005\u7d66\u85e5\u3002\u8a72\u7814\u7a76\u65e8\u5728\u8a55\u4f30BRII-297\u5728\u5065\u5eb7\u5fd7\u9858\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548c\u85e5\u4ee3\u52d5\u529b\u5b78\uff0c\u9810\u8a08\u5c07\u65bc2024\u5e74\u4e0b\u534a\u5e74\u7372\u5f97\u6578\u64da\u3002 <\/p>\n

2023\u5e74\u5168\u5e74\u8ca1\u52d9\u696d\u7e3e<\/p>\n

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