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ROS1-TKI \u6cbb\u7642\u7684 ROS1 \u967d\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005\u7684\u8feb\u5207\u9700\u6c42\uff0c\u4ee5\u53ca\u6cf0\u840a\u66ff\u5c3c\u70ba\u60a3\u8005\u5e36\u4f86\u986f\u8457\u81e8\u5e8a\u7372\u76ca\u7684\u6f5b\u529b\u3002\u6211\u5011\u975e\u5e38\u671f\u5f85\u914d\u5408\u4e2d\u570b\u76e3\u7ba1\u6a5f\u69cb\u5c0d\u6cf0\u840a\u66ff\u5c3c\u7684\u5be9\u67e5\uff0c\u722d\u53d6\u76e1\u65e9\u5c07\u9019\u9805\u7a81\u7834\u6027\u7642\u6cd5\u76e1\u5feb\u63d0\u4f9b\u7d66\u60a3\u8005\u3002\u300d<\/p>\n<p>\u6cf0\u840a\u66ff\u5c3c\u7684NDA \u7372\u53d7\u7406\u548c\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u662f\u57fa\u65bc\u4e00\u9805\u81e8\u5e8aII \u671fTRUST-I\u7814\u7a76 \uff08NCT04395677\uff09\u7684\u6578\u64da\u3002TRUST-I \u7814\u7a76\u7684\u671f\u4e2d\u5206\u6790\u6578\u64da\u65e9\u524d\u5728 2023 \u5e74\u6b50\u6d32\u80ba\u764c\u5927\u6703\uff08ELCC\uff09\u4e0a\u516c\u4f48\u3002<a href=\"https:\/\/www.anhearttherapeutics.com\/file.cfm\/14\/docs\/elcc_2023_talectrectinib.pdf\" target=\"_blank\" rel=\"noopener\">[\u93c8\u63a5]<\/a><\/p>\n<p>\u95dc\u65bcROS1\u967d\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c<\/p>\n<p>\u80ba\u764c\u662f\u5168\u7403\u767c\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u6700\u9ad8\u7684\u60e1\u6027\u816b\u7624\u4e4b\u4e00\uff0c\u5176\u4e2dNSCLC\u662f\u6700\u5e38\u898b\u7684\u75c5\u7406\u985e\u578b\uff0c\u5168\u7403\u6bcf\u5e74\u6709\u8d85\u904e\u4e00\u767e\u842c\u4eba\u88ab\u8a3a\u65b7\u60a3\u6709NSCLC\uff0c\u7d04\u5360\u6240\u6709\u80ba\u764c\u768485%\u3002\u64da\u4f30\u8a08\uff0c\u4e2d\u570b\u7d043%\u7684NSCLC\u60a3\u8005\u7684\u651c\u5e36ROS1\u967d\u6027\u57fa\u56e0\u3002\u76ee\u524d\u7372\u6279\u7684\u7b2c\u4e00\u4ee3 ROS TKI\u53ef\u4ee5\u7528\u65bc\u4e00\u7dda\u6cbb\u7642\u665a\u671f\u6216\u8f49\u79fb\u6027 ROS1 \u967d\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005\uff0c\u4f46\u60a3\u8005\u5f80\u5f80\u5728\u63a5\u53d7\u6cbb\u7642\u5f8c\u767c\u751f\u75be\u75c5\u9032\u5c55\uff0c\u5c0d\u6b64\u76ee\u524d\u5c1a\u672a\u6709\u7372\u6279\u7684\u6cbb\u7642\u65b9\u6848\u3002\u5728\u521d\u6cbb\u7684\u8f49\u79fb\u6027 ROS1 \u967d\u6027NSCLC\u60a3\u8005\u4e2d\uff0c\u9ad8\u9054 35% \u7684\u60a3\u8005\u816b\u7624\u5df2\u64f4\u6563\u5230\u5927\u8166\uff08\u5373\u767c\u751f\u8166\u8f49\u79fb\uff09\uff0c\u800c\u5c0d\u65bc\u7d93\u7b2c\u4e00\u4ee3ROS1 TKI\u6cbb\u7642\u5931\u6557\u7684\u60a3\u8005\uff0c\u767c\u751f\u8166\u8f49\u79fb\u7684\u6bd4\u4f8b\u589e\u52a0\u81f3\u9ad8\u9054 55%\u3002<\/p>\n<p>\u95dc\u65bc\u6cf0\u840a\u66ff\u5c3c<\/p>\n<p>\u6cf0\u840a\u66ff\u5c3c\u662f\u4e00\u7a2e\u53e3\u670d\u3001\u5f37\u6548\u3001\u8166\u6ef2\u900f\u3001\u9078\u64c7\u6027\u3001\u65b0\u4e00\u4ee3\u6f5b\u5728\u6700\u4f73 \u7684ROS1 \u6291\u5236\u5291\u3002\u6cf0\u840a\u66ff\u5c3c\u6b63\u5728\u5169\u9805\u81e8\u5e8aII\u671f\u7814\u7a76\u4e2d\u8a55\u4f30\u5176\u5728 ROS1 \u967d\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005\u4e2d\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\uff0c\u5206\u5225\u70ba\u5728\u4e2d\u570b\u958b\u5c55\u7684 TRUST-I\u7814\u7a76 (NCT04395677) \u548c\u5168\u7403\u95dc\u9375\u81e8\u5e8a TRUST-II\u7814\u7a76 (NCT04919811)\u3002<\/p>\n<p>\u6cf0\u840a\u66ff\u5c3c\u65bc2022\u5e743\u6708\u7372\u4e2d\u570bNMPA CDE\u6388\u4e88\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u7d93ROS1 TKI\u6cbb\u7642\u4ee5\u53ca\u65e2\u5f80\u672a\u7d93ROS1 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href=\"http:\/\/www.linkedin.com\/company\/innovent-biologics\/\" target=\"_blank\" rel=\"noopener\">www.linkedin.com\/company\/innovent-biologics\/<\/a>\u3002<\/p>\n<p>\u95dc\u65bc\u8446\u5143\u91ab\u85e5<\/p>\n<p>\u8446\u5143\u91ab\u85e5\uff08\u300c\u8446\u5143\u300d\uff09\u662f\u4e00\u5bb6\u81e8\u5e8a\u968e\u6bb5\u7684\u5168\u7403\u6027\u751f\u7269\u88fd\u85e5\u96c6\u5718\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u70ba\u764c\u75c7\u60a3\u8005\u958b\u767c\u65b0\u4e00\u4ee3\u7cbe\u6e96\u816b\u7624\u6cbb\u7642\u85e5\u7269\u3002\u5176\u4e3b\u8981\u7814\u767c\u85e5\u7269\u6cf0\u840a\u66ff\u5c3c\u662f\u65b0\u4e00\u4ee3\u540c\u985e\u4e2d\u6700\u512a\u7684 ROS1 \u6291\u5236\u5291\uff0c\u76ee\u524d\u6b63\u8655\u65bc\u95dc\u9375\u6027 2 \u671f\u8a66\u9a57\uff0c\u7528\u65bc\u6cbb\u7642 ROS1 \u878d\u5408\u967d\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7684\u65e2\u5f80\u672a\u7d93ROS1 TKI\u6cbb\u7642\u60a3\u8005\u548c\u5df2\u63a5\u53d7 ROS1 TKI 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