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\nIBI344 (ROS1) \uff1aROS1\u7a81\u8b8a\u80ba\u764c\uff0c\u95dc\u9375\u81e8\u5e8aII\u671f IBI351 (KRASG12C) \uff1aKRASG12C\u7a81\u8b8a\u80ba\u764c\uff0c\u95dc\u9375\u81e8\u5e8aII\u671f IBI126 (CEACAM5 ADC) \uff1aCEACAM5\u9ad8\u8868\u9054\u80ba\u764c\uff0c\u81e8\u5e8aIII\u671f
\n\u6297\u9ad4\u5e73\u53f0\u81f4\u529b\u5168\u7403\u5275\u65b0\uff0c\u5dee\u7570\u5316\u5206\u5b50\u8b80\u51fa\u521d\u6b65\u7a4d\u6975\u4fe1\u865f
\n\u5dee\u7570\u5316\u300c\u5168\u7403\u65b0\u300d\u96d9\u6297\uff1aPD-1\/IL-2, \u81e8\u5e8a\u524d\u7368\u7279\u6a5f\u7406\u767c\u73fe\u767c\u8868\u65bcNature Cancer\uff1bCLDN18.2\/CD3\uff1bEGFR\/B7H3\u7b49\u8655\u65bc\u81e8\u5e8a\u65e9\u671f\u63a2\u7d22\u968e\u6bb5 \u816b\u7624\u514d\u75ab\u55ae\u6297: LAG3\uff0cTIGIT\uff0cCTLA-4\u8655\u65bcPoC\u63a2\u7d22\u968e\u6bb5 <\/p>\n

\u52a0\u901fADC\u5e73\u53f0\u6210\u679c\u8f49\u5316<\/p>\n

IBI343 \uff08CLDN 18.2 ADC\uff09: \u6fb3\u5927\u5229\u4e9e\u53ca\u4e2d\u570b\u540c\u6b65\u958b\u5c55\u81e8\u5e8aI\u671f\uff0c\u5dee\u7570\u5316\u5206\u5b50\u8a2d\u8a08\uff0c\u81e8\u5e8a\u89c0\u5bdf\u5230\u521d\u6b65\u66f4\u5bec\u7684\u6cbb\u7642\u7a97\u53e3\u548c\u66f4\u53ef\u63a7\u7684\u5b89\u5168\u8010\u53d7\u6027 \u81e8\u5e8a\u524d\u5341\u6578\u6b3eADC\u9805\u76ee\u548c\u524d\u6cbf\u6280\u8853\u5132\u5099\u52a9\u529b\u5dee\u7570\u5316\u5275\u65b0 <\/p>\n

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\u4fe1\u5fc5\u6a02\u00ae\uff08\u6258\u840a\u897f\u55ae\u6297\u6ce8\u5c04\u6db2) \uff1a \u552f\u4e00\u7372\u6279\u7684\u4e2d\u570b\u539f\u7814PCSK9\u55ae\u6297\uff0c\u6cbb\u7642\u9ad8\u81bd\u56fa\u9187\u8840\u75c7\u548c\u6df7\u5408\u8840\u8102\u7570\u5e38
\n\u746a\u4ed5\u5ea6\u80bd (GLP-1R\/GCGR) \uff1a\u6f5b\u5728\u6700\u512a\u65b0\u4e00\u4ee3GLP-1\u96d9\u9776\uff0c\u52a0\u901f\u63a8\u9032\u6e1b\u91cd\u548c\u7cd6\u5c3f\u75c53\u671f\u6ce8\u518a\u81e8\u5e8a\u7814\u7a76\uff0c9mg\u80a5\u80d62\u671f 24\u5468\u6e1b\u91cd15.4%\uff0c\u7642\u6548\u53ef\u5ab2\u7f8e\u6e1b\u91cd\u624b\u8853
\nIBI128 (XOI): \u65b0\u4e00\u4ee3\u75db\u98a8\u9ad8\u5c3f\u9178\u8840\u75c7\u5019\u9078\u5206\u5b50\uff0c\u6f5b\u5728\u66f4\u512a\u7684\u7642\u6548\u8207\u5b89\u5168\u6027 \u5e03\u5c40\u4e0b\u4e00\u4ee3\u4ee3\u8b1d\u5206\u5b50\uff0c\u978f\u56faCVM\u7af6\u722d\u512a\u52e2 <\/p>\n

\u81ea\u8eab\u514d\u75ab\uff1a\u512a\u52e2\u5e03\u5c40\u81ea\u514d\u7d30\u5206\u9818\u57df<\/p>\n

IBI112 (IL-23p19) \uff1a\u6f5b\u5728\u6700\u512a\u7684\u9577\u671f\u7642\u6548\u512a\u52e2\u548c\u5ef6\u9577\u7d66\u85e5\u9593\u9694\uff0cIII\u671f\u6ce8\u518a\u81e8\u5e8a\u4e2d
\nIBI353 (PDE4\uff09\uff1a\u53e3\u670d\u6cbb\u7642\u9280\u5c51\u75c5\uff0c\u6d77\u5916II\u671f\u81e8\u5e8a\u7814\u7a76\u8b80\u51fa\u7a4d\u6975\u4fe1\u865f
\nIBI355\uff08CD40L\uff09\u3001IBI356 (OX40L)\uff1a\u7279\u8272\u5275\u65b0\u6027\u514d\u75ab\u5206\u5b50\u5373\u5c07\u9032\u5165\u81e8\u5e8a\u968e\u6bb5\uff0c\u63a2\u7d22\u672a\u6eff\u8db3\u81e8\u5e8a\u9700\u6c42\u7684\u81ea\u514d\u7d30\u5206\u9818\u57df <\/p>\n

\u773c\u79d1\uff1a\u65b0\u958b\u5169\u9805III\u671f\u81e8\u5e8a<\/p>\n

IBI302 (VEGF\/C) \uff1a\u81e8\u5e8aIII\u671f\u51c6\u5099\u5c31\u7dd2\uff0c\u9577\u9593\u9694\u7d66\u85e5\u6709\u671b\u5be6\u73fe\u512a\u7570\u7642\u6548\uff0c\u6f5b\u5728\u6539\u5584\u9ec3\u6591\u840e\u7e2e
\nIBI311 (IGF-1R) \uff1a\u552f\u4e00\u9032\u5165\u81e8\u5e8aIII\u671f\u65b0\u85e5\uff0c\u586b\u88dc\u7532\u72c0\u817a\u773c\u75c5\u6cbb\u7642\u7a7a\u767d\uff1b
\nIBI324\uff08VEGF\/ANG-2\uff09\u3001IBI333\uff08VEGF-C\/VEGF-A\uff09\uff1a\u9032\u5165\u81e8\u5e8aI\u671f\u7814\u7a76\uff0c\u63a2\u7d22VEGF\u55ae\u85e5\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42 <\/p>\n

\u6301\u7e8c\u63a8\u9032\u5168\u7403\u5275\u65b0<\/p>\n

\u7814\u767c\u5f15\u64ce\u2014\u2014\u570b\u6e05\u9662\u539a\u7a4d\u8584\u767c\uff1a
\n2023\u5e74\u4e0a\u534a\u5e74\u6210\u529f\u4ea4\u4ed84\u6b3e\u9ad8\u5dee\u7570\u5316\u7684\u5275\u65b0\u5206\u5b50\u9032\u5165IND\u51c6\u5099\u968e\u6bb5 \u91cd\u9ede\u52a0\u901f\u6297\u9ad4\u5e73\u53f0\u3001ADC\u5e73\u53f0\u6210\u679c\u8f49\u5316\uff0cBIC\u548cFIC\u5206\u5b50\u9010\u6b65\u9a57\u8b49 \u816b\u7624\u53ca\u6162\u75c5\u9818\u57df\u7acb\u9805\u5747\u8861\u5e03\u5c40\u3001\u5171\u540c\u5f15\u9818\u5275\u65b0\u6d6a\u6f6e <\/p>\n

\u79d1\u5b78\u63a2\u7d22\u5168\u7403\u6f5b\u529b\u5275\u65b0\u7ba1\u7dda\uff0c\u5e03\u5c40\u5168\u7403\u591a\u4e2d\u5fc3\uff08MRCT\uff09\u81e8\u5e8a\u958b\u767c<\/p>\n

\u816b\u7624\u53ca\u773c\u79d1\u5275\u65b0\u5206\u5b50PoC\u81e8\u5e8a\u9a57\u8b49\u4e2d \u6df1\u5ea6\u5275\u65b0FIC\/BIC\u5206\u5b50\uff1aPD-1\/IL-2, CLDN18.2 ADC I\u671fMRCT\u81e8\u5e8a\u53d6\u5f97\u521d\u6b65\u5dee\u7570\u5316\u81e8\u5e8a\u6578\u64da <\/p>\n

\u9ad8\u7aef\u751f\u7269\u91ab\u85e5\u7522\u696d\u5316\u57fa\u5730\u914d\u509914\u842c\u5347\u5927\u898f\u6a21\u4e0d\u92b9\u92fc\u7522\u80fd\uff0c\u5805\u5b88\u9ad8\u8cea\u91cf\u751f\u7522\u6a19\u51c6\uff0c\u751f\u7522\u7b26\u5408GMP\u8981\u6c42<\/p>\n

\u52a0\u5f37\u5408\u898f\u7ba1\u6cbb \u8e10\u884c\u7da0\u8272\u53ef\u6301\u7e8c\u767c\u5c55<\/p>\n

\u7a4d\u6975\u97ff\u61c9\u806f\u5408\u570b\u53ef\u6301\u7e8c\u767c\u5c55\u76ee\u6a19\uff08SDGs\uff09\uff0c\u5347\u7d1aESG\u3002\u7e7c\u7e8c\u5805\u6301\u4ee5\u4eba\u70ba\u672c\uff0c\u4ee5\u8aa0\u4fe1\u7d93\u71df\u70ba\u5e95\u8272\uff0c\u4ee5\u9ad8\u8cea\u91cf\u70ba\u57fa\u77f3\uff0c\u4ee5\u7da0\u8272\u751f\u614b\u70ba\u5c0e\u5411\uff0c\u4ee5\u5275\u65b0\u9a45\u52d5\u767c\u5c55\uff0c\u5207\u5be6\u7dad\u8b77\u5404\u5229\u76ca\u76f8\u95dc\u65b9\u7684\u6b0a\u76ca\uff0c\u7a4d\u6975\u4e3b\u52d5\u5c65\u884c\u793e\u6703\u8cac\u4efb \u66f4\u52a0\u91cd\u8996\u516c\u53f8\u6cbb\u7406\u5347\u7d1a\u3001\u5805\u6301\u5408\u898f\u7d93\u71df\u3001\u7d93\u71df\u6548\u7387\u63d0\u5347\u3001\u9ad8\u8cea\u91cf\u5275\u65b0\u3001\u54e1\u5de5\u591a\u5143\u5316\u8207\u8ce6\u80fd\u548c\u4f4e\u78b3\u767c\u5c55\uff0c\u81f4\u529b\u65bc\u63a8\u52d5\u666e\u60e0\u91ab\u7642\uff0c\u8b93\u66f4\u591a\u60a3\u8005\u5e73\u7b49\u5730\u4eab\u53d7\u5230\u53ef\u8ca0\u64d4\u7684\u9ad8\u8cea\u91cf\u5275\u65b0\u85e5 <\/p>\n

\u6548\u7387\u4e0d\u65b7\u63d0\u5347 \u8ca1\u52d9\u6307\u6a19\u5927\u5e45\u6539\u5584<\/p>\n

2023\u5e74\u4e0a\u534a\u5e74\uff0c\u5be6\u73fe\uff1a<\/p>\n

\u7e3d\u6536\u516527.02\u5104\uff0c\u540c\u6bd4\u589e\u957720.6% \u606f\u7a05\u6298\u820a\u53ca\u6524\u92b7\u524d\u6de8\u8667\u640d2.67\u5104\uff0c\u540c\u6bd4\u5927\u5e45\u7e2e\u6e1b74.2% \u6de8\u8667\u640d1.90\u5104\uff0c\u540c\u6bd4\u5927\u5e45\u7e2e\u6e1b82.5%
*\u8667\u640d\u7e2e\u6e1b\u4e3b\u8981\u5f97\u76ca\u65bc\u6536\u5165\u7684\u5feb\u901f\u589e\u9577\uff0c\u4ee5\u53ca\u5805\u6301\u7cbe\u76ca\u904b\u71df\u5404\u65b9\u9762\u7d93\u71df\u6548\u7387\u6301\u7e8c\u63d0\u9ad8
*\u73fe\u968e\u6bb5\u8667\u640d\u4e3b\u8981\u7528\u65bc\u6301\u7e8c\u7684\u7814\u767c\u6295\u5165\u4ee5\u652f\u6301\u5168\u7403\u5275\u65b0\u7684\u9577\u671f\u6230\u7565
\n \u7814\u767c\u6295\u51658.26\u5104\u4eba\u6c11\u5e63\uff1b\u73fe\u91d1\u5132\u509985.27\u5104\u4eba\u6c11\u5e63\uff08\u6298\u5408\u7d0412\u5104\u7f8e\u5143\uff09
*\u70ba\u516c\u53f8\u6301\u7e8c\u5c08\u6ce8\u9577\u671f\u767c\u5c55\u63d0\u4f9b\u5805\u5be6\u4fdd\u969c<\/p>\n

\n

\u6ce8\uff1a\u672c\u6587\u63d0\u53ca\u7684\u8ca1\u52d9\u6578\u64da\u5747\u91c7\u7528\u975e\u570b\u969b\u8ca1\u52d9\u5831\u544a\u51c6\u5247\u8a08\u91cf\uff0c\u8a73\u60c5\u8acb\u53c3\u95b1\u96c6\u5718\u696d\u7e3e\u516c\u544a\u3002<\/span><\/p>\n<\/div>\n

\u95dc\u65bc\u4fe1\u9054\u751f\u7269<\/p>\n

\u300c\u59cb\u65bc\u4fe1\uff0c\u9054\u65bc\u884c\u300d\uff0c\u958b\u767c\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8cea\u91cf\u751f\u7269\u85e5\uff0c\u662f\u4fe1\u9054\u751f\u7269\u7684\u4f7f\u547d\u548c\u76ee\u6a19\u3002\u4fe1\u9054\u751f\u7269\u6210\u7acb\u65bc2011\u5e74\uff0c\u81f4\u529b\u65bc\u958b\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u7684\u5275\u65b0\u85e5\u7269\u3002\u516c\u53f8\u5df2\u670910\u500b\u7522\u54c1\u7372\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c\u5b83\u5011\u5206\u5225\u662f\u4fe1\u8fea\u5229\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u4f2f\u8212\u00ae\uff09\uff0c\u8c9d\u4f10\u73e0\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u6538\u540c\u00ae\uff09\uff0c\u963f\u9054\u6728\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u8607\u7acb\u4fe1\u00ae\uff09\uff0c\u5229\u59a5\u6614\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u4f2f\u83ef\u00ae\uff09\uff0c\u4f69\u7c73\u66ff\u5c3c\u7247\uff08\u9054\u4f2f\u5766\u00ae\uff09\uff0c\u5967\u96f7\u5df4\u66ff\u5c3c\u7247\uff08\u8010\u7acb\u514b\u00ae\uff09\uff0c \u96f7\u83ab\u897f\u5c24\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u5e0c\u5189\u64c7\u00ae\uff09\uff0c\u585e\u666e\u66ff\u5c3c\u81a0\u56ca\uff08\u777f\u59a5\u00ae\uff09\uff0c\u4f0a\u57fa\u5967\u4f96\u8cfd\u6ce8\u5c04\u6db2\uff08\u798f\u53ef\u8607\u00ae\uff09\u548c\u6258\u840a\u897f\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u4fe1\u5fc5\u6a02\u00ae\uff09\u3002\u76ee\u524d\uff0c\u540c\u6642\u9084\u67091\u500b\u54c1\u7a2e\u5728NMPA\u5be9\u8a55\u4e2d\uff0c7\u500b\u65b0\u85e5\u5206\u5b50\u9032\u5165III\u671f\u6216\u95dc\u9375\u6027\u81e8\u5e8a\u7814\u7a76\uff0c\u53e6\u5916\u9084\u670917\u500b\u65b0\u85e5\u54c1\u7a2e\u5df2\u9032\u5165\u81e8\u5e8a\u7814\u7a76\u3002<\/p>\n

\u516c\u53f8\u5df2\u8207\u79ae\u4f86\u3001\u7f85\u6c0f\u3001\u8cfd\u8afe\u83f2\u3001Adimab\u3001Incyte\u548cMD Anderson \u764c\u75c7\u4e2d\u5fc3\u7b49\u570b\u969b\u5408\u4f5c\u65b9\u9054\u621030\u9805\u6230\u7565\u5408\u4f5c\u3002\u4fe1\u9054\u751f\u7269\u5728\u4e0d\u65b7\u81ea\u7814\u5275\u65b0\u85e5\u7269\u3001\u8b00\u6c42\u81ea\u8eab\u767c\u5c55\u7684\u540c\u6642\uff0c\u79c9\u627f\u7d93\u6fdf\u5efa\u8a2d\u4ee5\u4eba\u6c11\u70ba\u4e2d\u5fc3\u7684\u767c\u5c55\u601d\u60f3\u3002\u591a\u5e74\u4f86\uff0c\u59cb\u7d42\u5fc3\u61f7\u79d1\u5b78\u5584\u5ff5\uff0c\u5805\u5b88\u300c\u4ee5\u60a3\u8005\u70ba\u4e2d\u5fc3\u300d\uff0c\u5fc3\u7cfb\u60a3\u8005\u4e26\u95dc\u6ce8\u60a3\u8005\u5bb6\u5ead\uff0c\u7a4d\u6975\u5c65\u884c\u793e\u6703\u8cac\u4efb\u3002\u516c\u53f8\u9678\u7e8c\u767c\u8d77\u3001\u53c3\u8207\u4e86\u591a\u9805\u85e5\u54c1\u516c\u76ca\u63f4\u52a9\u9805\u76ee\uff0c\u8b93\u8d8a\u4f86\u8d8a\u591a\u7684\u60a3\u8005\u80fd\u5920\u5f97\u76ca\u65bc\u751f\u547d\u79d1\u5b78\u7684\u9032\u6b65\uff0c\u7528\u5f97\u4e0a\u3001\u7528\u5f97\u8d77\u9ad8\u8cea\u91cf\u7684\u751f\u7269\u85e5\u3002\u81f32023\u5e743\u6708\uff0c\u4fe1\u9054\u751f\u7269\u60a3\u8005\u63f4\u52a9\u9805\u76ee\u5df2\u60e0\u53ca16\u4f59\u842c\u666e\u901a\u60a3\u8005\uff0c\u85e5\u7269\u6350\u8d08\u7e3d\u50f9\u503c\u6578\u5104\u5143\u3002\u4fe1\u9054\u751f\u7269\u5e0c\u671b\u548c\u5927\u5bb6\u4e00\u8d77\u52aa\u529b\uff0c\u63d0\u9ad8\u4e2d\u570b\u751f\u7269\u5236\u85e5\u7522\u696d\u7684\u767c\u5c55\u6c34\u5e73\uff0c\u4ee5\u6eff\u8db3\u767e\u59d3\u7528\u85e5\u53ef\u53ca\u6027\u548c\u4eba\u6c11\u5c0d\u751f\u547d\u5065\u5eb7\u7f8e\u597d\u9858\u671b\u7684\u8ffd\u6c42\u3002<\/p>\n

\u8a73\u60c5\u8acb\u8a2a\u554f\u516c\u53f8\u7db2\u7ad9\uff1awww.innoventbio.com\u6216\u516c\u53f8\u9818\u82f1\u8cec\u865fwww.linkedin.com\/company\/innovent-biologics\/\u3002<\/p>\n

\u524d\u77bb\u6027\u8072\u660e<\/p>\n

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