{"id":13905,"date":"2023-07-28T11:32:00","date_gmt":"2023-07-28T03:32:00","guid":{"rendered":"https:\/\/www.franchise.com.hk\/%e7%b6%ad%e4%ba%9e%e7%94%9f%e7%89%a97%e5%ae%b6%e6%8a%95%e8%b3%87%e5%ad%b5%e5%8c%96%e5%85%ac%e5%8f%b8%e8%bf%91%e6%9c%9f%e7%99%bc%e5%b1%95%e5%8b%95%e6%85%8b%e4%b8%80%e8%a6%bd\/13905"},"modified":"2023-07-28T11:32:00","modified_gmt":"2023-07-28T03:32:00","slug":"%e7%b6%ad%e4%ba%9e%e7%94%9f%e7%89%a97%e5%ae%b6%e6%8a%95%e8%b3%87%e5%ad%b5%e5%8c%96%e5%85%ac%e5%8f%b8%e8%bf%91%e6%9c%9f%e7%99%bc%e5%b1%95%e5%8b%95%e6%85%8b%e4%b8%80%e8%a6%bd","status":"publish","type":"post","link":"https:\/\/www.franchise.com.hk\/zh-hans\/%e7%b6%ad%e4%ba%9e%e7%94%9f%e7%89%a97%e5%ae%b6%e6%8a%95%e8%b3%87%e5%ad%b5%e5%8c%96%e5%85%ac%e5%8f%b8%e8%bf%91%e6%9c%9f%e7%99%bc%e5%b1%95%e5%8b%95%e6%85%8b%e4%b8%80%e8%a6%bd\/13905","title":{"rendered":"\u7dad\u4e9e\u751f\u72697\u5bb6\u6295\u8cc7\u5b75\u5316\u516c\u53f8\u8fd1\u671f\u767c\u5c55\u52d5\u614b\u4e00\u89bd"},"content":{"rendered":"<p><span class=\"legendSpanClass\">\u9999\u6e2f<\/span><span class=\"legendSpanClass\">2023\u5e747\u670828\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u9762\u5c0d\u4e0d\u65b7\u8b8a\u5316\u7684\u5c40\u52e2\uff0c\u6280\u8853\u5275\u65b0\u4f9d\u820a\u662f\u751f\u7269\u91ab\u85e5\u4f01\u696d\u9577\u9060\u767c\u5c55\u6c38\u6046\u7684\u4e3b\u65cb\u5f8b\uff0c\u70ba\u4f01\u696d\u6e90\u6e90\u4e0d\u65b7\u5730\u6ce8\u5165\u751f\u547d\u529b\uff0c\u6301\u7e8c\u63a8\u52d5\u7814\u767c\u300c\u5f9e0\u52301\u300d\u8f49\u5316\u4ee5\u53ca\u5546\u696d\u5316\u6210\u529f\u3002\u8fd1\u671f\uff0c\u7dad\u4e9e7\u5bb6\u6295\u8cc7\u5b75\u5316\u4f01\u696d\u53c8\u6709\u65b0\u7684\u52d5\u614b\uff1aDTx Pharma\u8207\u8afe\u83ef\u9054\u6210\u6536\u8cfc\u5354\u5b9a\uff1bRiparian \u8207\u8f1d\u745e\u9054\u6210\u7368\u5bb6\u8a31\u53ef\u5354\u8b70\u548c\u7814\u7a76\u5354\u8b70\uff1bArthrosi\u6210\u529f\u5b8c\u6210\u878d\u8cc7\uff1bAceLink\u3001\u7dad\u7738\u751f\u7269\u3001Domain\u5728\u5404\u81ea\u7814\u767c\u9818\u57df\u5747\u53d6\u5f97\u4e0d\u932f\u7684\u9032\u5c55\uff1bHAYA\u4efb\u547d\u81e8\u5e8a\u9867\u554f\u59d4\u54e1\u6703\u4e3b\u5e2d\u3002<\/p>\n<p>Riparian Pharmaceuticals \u5ba3\u4f48\u8207\u8f1d\u745e\u9054\u6210\u5fc3\u8840\u7ba1\u9805\u76ee\u7368\u5bb6\u8a31\u53ef\u5354\u8b70\u548c\u7814\u7a76\u5354\u8b70<\/p>\n<p>\u99ac\u85a9\u8af8\u585e\u5dde\u6c83\u7279\u6566\u2014\u20142023\u5e747\u670819\u65e5\uff0c\u7dad\u4e9e\u751f\u7269\u53c3\u8207\u6295\u8cc7\u5b75\u5316\u7684\u751f\u7269\u6280\u8853\u516c\u53f8Riparian Pharmaceuticals\u5ba3\u4f48\u5df2\u8207\u8f1d\u745e\u9054\u6210\u7368\u5bb6\u8a31\u53ef\u5354\u8b70\u548c\u7814\u7a76\u5354\u8b70\u3002\u8f1d\u745e\u5c07\u652f\u4ed8\u9810\u4ed8\u6b3e\u548c\u91cc\u7a0b\u7891\u4ed8\u6b3e\uff0c\u53ca\u672a\u4f86\u7642\u6cd5\u7684\u92b7\u552e\u5206\u6210\uff0c\u4ee5\u63db\u53d6\u5c0dRiparian\u81e8\u5e8a\u524d\u9805\u76ee\u7684\u5c08\u6709\u6b0a\u3002\u4f5c\u70ba\u7814\u7a76\u5354\u8b70\u7684\u4e00\u90e8\u5206\uff0c\u8f1d\u745e\u5c07\u652f\u6301Riparian\u767c\u73fe\u66f4\u591a\u6709\u8840\u7ba1\u4fdd\u8b77\u4f5c\u7528\u7684\u85e5\u7269\u9776\u9ede\uff0c\u4e26\u5c0d\u9019\u4e9b\u9776\u9ede\u64c1\u6709\u9078\u64c7\u6b0a\u3002<\/p>\n<p>\u7dad\u4e9e\u751f\u7269\u9996\u5e2d\u79d1\u5b78\u5b98\u8449\u5fd7\u96c4\u535a\u58eb\u8868\u793a\uff1a\u300c\u7dad\u4e9e\u751f\u7269\u81ea2018\u5e749\u6708\u8d77\u6295\u8cc7\u5b75\u5316 Riparian\uff0c\u6211\u5011\u5c31\u5168\u65b0\u9776\u9ede\u7684\u767c\u73fe\u4ee5\u53ca\u5316\u5408\u7269\u8a2d\u8a08\u5408\u6210\u53ca\u6e2c\u8a66\u8207 Riparian \u5718\u968a\u5c55\u958b\u9577\u671f\u5408\u4f5c\u3002\u7dad\u4e9e\u6191\u85c9\u591a\u5e74\u5728 First-in-class \u85e5\u7269\u7814\u767c\u9818\u57df\u7684\u7d93\u9a57\u8207\u7368\u7279\u5e73\u53f0\u512a\u52e2\uff0c\u758a\u52a0\u4e00\u7ad9\u5f0f\u7d9c\u5408\u670d\u52d9\u80fd\u529b\uff0c\u901a\u904e\u8cc7\u6df1\u79d1\u5b78\u5bb6\u5718\u968a\u7684\u5c08\u696d\u9818\u5c0e\uff0c\u52a9\u529b Riparian \u7814\u767c\u4e86\u512a\u8cea\u7684\u81e8\u5e8a\u5019\u9078\u85e5\u7269\u3002\u300d<\/p>\n<p>DTx Pharma \u5ba3\u4f48\u8207\u8afe\u83ef\u9054\u6210\u6536\u8cfc\u5354\u8b70<\/p>\n<p><span>\u52a0\u5dde<\/span><span>\u8056\u5730\u4e9e\u54e5<\/span>\u2014\u20142023\u5e747\u670817\u65e5\uff0c\u7dad\u4e9e\u53c3\u8207\u6295\u8cc7\u5b75\u5316\u7684 DTx Pharma \u662f\u4e00\u5bb6\u81e8\u5e8a\u524d\u968e\u6bb5\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u5229\u7528\u5176\u8102\u80aa\u9178\u914d\u9ad4\u5171\u8edb\u5be1\u6838\u82f7\u9178 (FALCON\u2122) \u5e73\u53f0\u89e3\u6c7a\u5be1\u6838\u82f7\u9178\u7642\u6cd5\u7684\u905e\u9001\u6311\u6230\uff0c\u5176\u5ba3\u4f48\u8207\u8afe\u83ef\u9054\u6210\u6536\u8cfc\u5354\u8b70\u3002\u6839\u64da\u96d9\u65b9\u5354\u8b70\u689d\u6b3e\uff0c\u8afe\u83ef\u5c07\u652f\u4ed85\u5104\u7f8e\u5143\u7684\u9810\u4ed8\u6b3e\uff0c\u4e26\u5728\u5b8c\u6210\u9810\u5148\u6307\u5b9a\u7684\u91cc\u7a0b\u7891\u5f8c\u984d\u5916\u652f\u4ed8\u6700\u591a5\u5104\u7f8e\u5143\u3002FALCON\u5e73\u53f0\u80fd\u5920\u5c07\u5c0f\u5e72\u64feRNA (siRNA) \u6cbb\u7642\u85e5\u7269\u8f38\u9001\u5230\u809d\u81df\u4ee5\u5916\u7684\u7d44\u7e54\u4e26\u767c\u63ee\u5176\u6d3b\u6027\uff0c\u5f9e\u800c\u589e\u5f37siRNA\u85e5\u7269\u7684\u751f\u7269\u5206\u4f48\u548c\u7d30\u80de\u651d\u53d6\u3002DTx Pharma \u7684\u9818\u5148\u7ba1\u7dda DTx-1252\u76ee\u524d\u6b63\u5728\u9032\u884c\u81e8\u5e8a\u524d\u958b\u767c\uff0c\u4e26\u7372\u5f97 FDA \u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff0c\u7528\u65bc\u6cbb\u76421A\u578b\u8153\u9aa8\u808c\u840e\u7e2e\u75c7 (CMT1A)\u3002\u9664\u4e86 CMT1A \u9805\u76ee\u5916\uff0c\u8afe\u83ef\u9084\u7372\u5f97\u4e86FALCON \u5e73\u53f0\u548c\u53e6\u5916\u5169\u500b\u65e9\u671f\u9805\u76ee\uff08\u91dd\u5c0d\u795e\u7d93\u808c\u8089\u548c\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u9069\u61c9\u75c7\uff09\u7684\u5168\u90e8\u6b0a\u529b\u3002<\/p>\n<p>\u7dad\u4e9e\u751f\u7269\u9996\u5e2d\u5275\u65b0\u5b98\u517c\u7dad\u4e9e\u751f\u7269\u5275\u65b0\u4e2d\u5fc3\u8ca0\u8cac\u4eba\u6234\u6657\u535a\u58eb\u8868\u793a\uff1a\u300c\u6211\u5011\u5f88\u9ad8\u8208\u898b\u8b49\u4e26\u966a\u4f34\u4e86 DTx Pharma \u5f9e\u6982\u5ff5\u9a57\u8b49\u5230\u81e8\u5e8a\u524d\u7814\u7a76\u9019\u4e00\u8def\u7684\u6210\u9577\uff0c\u4e26\u53c3\u8207\u5176\u591a\u8f2a\u878d\u8cc7\u3002\u672c\u6b21\u9054\u6210\u6536\u8cfc\uff0c\u4e5f\u518d\u6b21\u9a57\u8b49\u4e86\u7dad\u4e9e\u6295\u8cc7\u5718\u968a\u7684\u6230\u7565\u773c\u5149\u53ca\u5c08\u696d\u7684\u6295\u5f8c\u652f\u6301\u3002\u300d<\/p>\n<p>Arthrosi Therapeutics \u6210\u529f\u7372\u5f977500\u842c\u7f8e\u5143\u7684D\u8f2a\u878d\u8cc7<\/p>\n<p><span>\u52a0\u5dde\u8056\u5730\u4e9e\u54e5\u2014\u20142023\u5e747\u670811\u65e5<\/span><span>\uff0c<\/span>\u7dad\u4e9e\u751f\u7269\u53c3\u8207\u6295\u8cc7\u5b75\u5316\u7684\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u6280\u8853\u516c\u53f8 Arthrosi Therapeutics \u5ba3\u4f48\u6210\u529f\u7372\u5f977500\u842c\u7f8e\u5143\u7684D\u8f2a\u878d\u8cc7\u3002\u672c\u8f2a\u878d\u8cc7\u7531\u5ee3\u6f64\u5927\u5065\u5eb7\u7522\u696d\uff08\u9999\u6e2f\uff09\u6709\u9650\u516c\u53f8\uff08\u82f1\u6587\u300cGuangrun Health Industry (<span class=\"xn-location\">Hong Kong<\/span>) Co. Limited\u300d\uff09\u9818\u6295\uff0c\u4e26\u5f97\u5230\u5305\u62ec\u4e00\u54c1\u7d05\u85e5\u696d\u5b50\u516c\u53f8\u745e\u9a30\u751f\u7269\uff08\u9999\u6e2f\uff09\u6709\u9650\u516c\u53f8\uff08\u82f1\u6587\u540d\u300cReichstein Biotech (HK) Co.Limited\u300d\uff09\u5728\u5167\u7684\u4e00\u6279\u6295\u8cc7\u8005\u8ca1\u5718\u7684\u652f\u6301\u3002\u6b64\u6b21\u878d\u8cc7\u662f\u5176\u5728\u7814\u7684\u6cbb\u7642\u6162\u6027\u75db\u98a8\u85e5\u7269AR882\u958b\u767c\u7684\u53c8\u4e00\u500b\u91cc\u7a0b\u7891\u3002AR882\u662f\u4e00\u7a2e\u9ad8\u6548\u9078\u64c7\u6027\u7684\u4e0b\u4e00\u4ee3URAT1\u6291\u5236\u5291\uff0c\u4ee5\u6bcf\u65e5\u4e00\u6b21\u7684\u5373\u6642\u91cb\u653e\u53e3\u670d\u81a0\u56ca\u7684\u5f62\u5f0f\u7d66\u85e5\u3002AR882\u6709\u6f5b\u529b\u6539\u8b8a\u75db\u98a8\u7684\u6cbb\u7642\u7bc4\u5f0f\uff0c\u89e3\u6c7a\u8840\u6e05\u5c3f\u9178 (sUA) \u6c34\u5e73\u3001\u75db\u98a8\u767c\u4f5c\u548c\u75db\u98a8\u77f3\u9084\u539f\u7b49\u554f\u984c\u3002<\/p>\n<p>AceLink Therapeutics \u7372FDA\u6279\u51c6\u555f\u52d5AL1211\u5c0d\u6cd5\u5e03\u745e\u6c0f\u75c5\u60a3\u8005\u76842\u671f\u7814\u7a76<\/p>\n<p>\u52a0\u5dde\u7d10\u74e6\u514b\u2014\u2014\u7531\u7dad\u4e9e\u751f\u7269\u53c3\u8207\u6295\u8cc7\u5b75\u5316\u7684 AceLink Therapeutics, Inc. \u662f\u4e00\u5bb6\u81e8\u5e8a\u968e\u6bb5\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u6b63\u5728\u958b\u767c\u4e0b\u4e00\u4ee3\u53e3\u670d\u5e95\u7269\u9084\u539f\u7642\u6cd5 (SRT)\uff0c\u4ee5\u6eff\u8db3\u91cd\u5927\u7684\u672a\u6eff\u8db3\u91ab\u7642\u9700\u6c42\uff0c\u6539\u5584\u907a\u50b3\u6027\u7cd6\u78f7\u8102\u4ee3\u8b1d\u7d0a\u4e82\u60a3\u8005\u7684\u751f\u6d3b\u8cea\u91cf\uff0c6\u670821\u65e5\u5ba3\u4f48\u5176\u5df2\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u548c\u85e5\u7269\u7ba1\u7406\u5c40 (FDA) \u7684\u8a31\u53ef\uff0c\u555f\u52d5\u5176\u9818\u5148\u9805\u76ee AL1211\u7684\u7b2c\u4e8c\u968e\u6bb5\u81e8\u5e8a\u8a66\u9a57\u3002<\/p>\n<p>\u7dad\u7738\u751f\u7269\u81ea\u4e3b\u7814\u767c\u7684\u9752\u5149\u773c\u96d9\u9776\u9ede\u5275\u65b0\u85e5 VVN539\u7f8e\u570bII\u671f\u81e8\u5e8a\u9054\u5230\u4e3b\u8981\u7814\u7a76\u7d42\u9ede<\/p>\n<p>\u8fd1\u671f\uff0c\u7531\u7dad\u4e9e\u751f\u7269\u53c3\u8207\u6295\u8cc7\u5b75\u5316\u7684\u7dad\u7738\u751f\u7269\u79d1\u6280\uff08\u4e0a\u6d77\uff09\u6709\u9650\u516c\u53f8\uff08\u300c\u7dad\u7738\u751f\u7269\u300d\uff09\u805a\u7126\u5dee\u7570\u5316\u548c\u5168\u7403\u65b0\u958b\u767c\u7684\u773c\u79d1\u5275\u65b0\u85e5\u516c\u53f8\uff0c\u5ba3\u4f48\u5176\u81ea\u4e3b\u7814\u767c\u7684\u96d9\u9776\u9ede\u85e5\u7269 VVN539\uff0c\u91dd\u5c0d\u958b\u89d2\u578b\u9752\u5149\u773c\u6216\u9ad8\u773c\u58d3\u60a3\u8005\u7684\u7f8e\u570bII\u671f\u81e8\u5e8a\u9054\u5230\u4e3b\u8981\u7814\u7a76\u7d42\u9ede\u3002<\/p>\n<p>\u8207\u6eb6\u5a92\u7d44\u76f8\u6bd4\uff0c0.04% VVN539\u5291\u91cf\u7d44\u5728\u6240\u6709\u6642\u9593\u9ede\u5747\u9054\u5230\u4e86\u7d71\u8a08\u5b78\u986f\u8457\u6027\u53ca\u81e8\u5e8a\u986f\u8457\u6027\uff0c\u773c\u58d3\u964d\u58d3\u5e45\u5ea6\u7d04\u70ba5~6 mmHg\u30020.02% VVN539\u5291\u91cf\u7d44\u5728\u5927\u591a\u6578\u6642\u9593\u9ede\u76f8\u8f03\u65bc\u6eb6\u5a92\u7d44\u4e5f\u9054\u5230\u4e86\u5177\u6709\u7d71\u8a08\u5b78\u610f\u7fa9\u7684\u773c\u58d3\u4e0b\u964d\u3002\u7814\u7a76\u4e2d\u672a\u89c0\u5bdf\u5230\u986f\u8457\u7684\u8207\u6cbb\u7642\u76f8\u95dc\u7684\u4e0d\u826f\u4e8b\u4ef6\u3002<\/p>\n<p>Domain Therapeutics \u5ba3\u4f48\u63d0\u540d\u9996\u5275 PAR2 NAM \u5019\u9078\u85e5\u7269 DT-9045<\/p>\n<p><span>\u6cd5\u570b\u65af\u7279\u62c9\u65af\u5821\u548c\u52a0\u62ff\u5927\u8499\u7279\u5229\u723e<\/span>\u2014\u2014\u7531\u7dad\u4e9e\u751f\u7269\u53c3\u8207\u6295\u8cc7\u5b75\u5316\u7684 Domain Therapeutics\uff08\u7c21\u7a31\u300cDomain\u300d\uff09\u662f\u4e00\u5bb6\u8655\u65bc\u81e8\u5e8a\u968e\u6bb5\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u958b\u767c\u91dd\u5c0dG\u86cb\u767d\u5076\u806f\u53d7\u9ad4 (GPCR) \u7684\u514d\u75ab\u816b\u7624\u5b78\u5275\u65b0\u5019\u9078\u85e5\u7269\uff0c\u65bc6\u67085\u65e5\u5ba3\u4f48\u63d0\u540d\u5176\u5019\u9078\u85e5\u7269 DT-9045\u3002DT-9045\u662f\u4e00\u7a2e\u86cb\u767d\u9176\u6d3b\u5316\u53d7\u9ad42 (PAR2) \u7684\u8ca0\u5411\u8b8a\u69cb\u8abf\u7bc0\u5291 (NAM)\uff0c\u5728\u514d\u75ab\u816b\u7624\u5b78\u65b9\u9762\u6cbb\u7642\u6f5b\u529b\u5de8\u5927\uff0c\u5c24\u5176\u9069\u7528\u65bc\u7e96\u7dad\u7624\u3002<\/p>\n<p>Domain \u63d0\u540d DT-9045\u4f5c\u70ba\u5176\u9996\u5275 PAR2 NAM \u81e8\u5e8a\u5019\u9078\u85e5\u7269\uff0c\u5f97\u76ca\u65bc DT-9045\u7684\u9644\u52a0\u503c\u3001\u7368\u7279\u6027\u53ca\u8207\u76ee\u524d\u81e8\u5e8a\u4e0a\u91dd\u5c0d PAR2\u7684\u751f\u7269\u88fd\u5291\u76f8\u6bd4\uff0c\u5176\u5177\u6709\u66f4\u5927\u7684\u6cbb\u7642\u6f5b\u529b\u3002\u5728\u5c0f\u9f20\u540c\u7a2e\u79fb\u690d\u6a21\u578b\u4e2d\uff0cDT-9045\u5df2\u7d93\u8b49\u660e\u4e86\u6982\u5ff5\u9a57\u8b49\u7684\u6709\u6548\u6027\uff0c\u53ef\u4ee5\u589e\u5f37\u6297 PD1\u6cbb\u7642\u7684\u6297\u816b\u7624\u6d3b\u6027\u3002<\/p>\n<p>HAYA Therapeutics \u4efb\u547d\u91ab\u5b78\u535a\u58eb <span class=\"xn-person\">Douglas L. Mann<\/span> \u70ba\u81e8\u5e8a\u9867\u554f\u59d4\u54e1\u6703\u4e3b\u5e2d<\/p>\n<p>\u745e\u58eb\u6d1b\u6851\u548c<span>\u52a0\u5dde<\/span><span>\u8056\u5730\u4e9e\u54e5<\/span>\u2014\u20146\u670820\u65e5\uff0c\u7531\u7dad\u4e9e\u751f\u7269\u53c3\u8207\u6295\u8cc7\u5b75\u5316\u7684\u3001\u4e00\u5bb6\u958b\u767c\u9776\u5411\u7d44\u7e54\u548c\u7d30\u80de\u7279\u7570\u6027\u9577\u975e\u7de8\u78bc RNA (lncRNA) \u7684\u7cbe\u6e96\u85e5\u7269\u516c\u53f8 HAYA Therapeutics \u5ba3\u4f48\uff0cDouglas L. Mann \u535a\u58eb\u52a0\u5165\u516c\u53f8\u64d4\u4efb\u81e8\u5e8a\u9867\u554f\u59d4\u54e1\u6703\u4e3b\u5e2d\u3002\u4f5c\u70ba\u4e00\u540d\u516c\u8a8d\u7684\u5fc3\u81df\u75c5\u5c08\u5bb6\u3001\u81e8\u5e8a\u7814\u7a76\u8005\u53ca\u5fc3\u8840\u7ba1\u7814\u7a76\u4eba\u54e1\uff0cMann \u535a\u58eb\u7684\u52a0\u5165\uff0c\u5c07\u6709\u52a9\u65bc HAYA Therapeutics \u5fc3\u529b\u8870\u7aed\u5019\u9078\u85e5\u7269 HTX-001\u63a8\u5411\u81e8\u5e8a\u3002<\/p>\n<p>\u95dc\u65bc Riparian Pharmaceuticals<\/p>\n<p>Riparian Pharmaceuticals, Inc. \u662f\u4e00\u5bb6\u79c1\u4eba\u6301\u80a1\u7684\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u767c\u73fe\u5f71\u97ff\u5167\u76ae\u529f\u80fd\u969c\u7919\u548c\u8840\u7ba1\u708e\u75c7\u7684\u85e5\u7269\u9776\u9ede\u548c\u7642\u6cd5\u3002\u9019\u5169\u500b\u904e\u7a0b\u662f\u591a\u7a2e\u5fc3\u81df\u4ee3\u8b1d\u6027\u75be\u75c5\u7684\u57fa\u790e\u548c\u8a98\u56e0\u3002Riparian \u5df2\u5f9e Viva Biotech \u548c JMCR Partners \u7b49\u7372\u5f97\u4e86\u7e3d\u8a08600\u842c\u7f8e\u5143\u7684\u6295\u8cc7\u548c\u7814\u7a76\u670d\u52d9\uff0c\u540c\u6642\u9084\u5f97\u5230\u4e86\u7f8e\u570b\u570b\u7acb\u885b\u751f\u7814\u7a76\u9662\u548c\u99ac\u85a9\u8af8\u585e\u5dde\u751f\u547d\u79d1\u5b78\u4e2d\u5fc3\u7b49\u7814\u7a76\u57fa\u91d1\u6703\u7684\u652f\u6301\u3002<\/p>\n<p>\u95dc\u65bc DTx Pharma<\/p>\n<p>DTx Pharma, Inc. \u662f\u4e00\u5bb6\u79c1\u71df\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u5229\u7528\u5176\u5c08\u6709\u7684\u8102\u80aa\u9178\u914d\u9ad4\u5171\u8edb\u5be1\u6838\u82f7\u9178 (FALCON\u2122) \u6280\u8853\u5e73\u53f0\u89e3\u6c7a RNAi \u7642\u6cd5\u6cbb\u7642\u809d\u81df\u4ee5\u5916\u75be\u75c5\u7684\u76f8\u95dc\u6311\u6230\u3002FALCON \u5e73\u53f0\u5229\u7528\u8102\u80aa\u9178\u4f86\u589e\u5f37\u5168\u8eab\u7d44\u7e54\u548c\u7d30\u80de\u985e\u578b\u7684\u751f\u7269\u5206\u4f48\u548c\u7d30\u80de\u651d\u53d6\u3002\u5728\u81e8\u5e8a\u524d\u7814\u7a76\u4e2d\uff0cFALCON siRNA\u5df2\u8b49\u660e\u80fd\u5920\u6709\u6548\u4e14\u6301\u4e45\u5730\u6291\u5236\u5468\u570d\u795e\u7d93\u7cfb\u7d71 (PNS)\u3001\u9aa8\u9abc\u808c\u3001\u5fc3\u81df\u3001\u76ae\u819a\u548c\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u4e2d\u7684\u9776\u57fa\u56e0\u3002FALCON siRNA \u53ef\u4ee5\u901a\u904e\u975c\u8108\u5167\u3001\u76ae\u4e0b\u548c\u9798\u5167\u7d66\u85e5\u9014\u5f91\u905e\u9001\uff0c\u4e26\u4e14\u53ef\u4ee5\u4ee5\u76f8\u5c0d\u8f03\u4f4e\u7684\u6210\u672c\u88fd\u9020\u3002\u8a72\u516c\u53f8\u64c1\u6709\u5c08\u6ce8\u4e8e\u5916\u5468\u795e\u7d93\u7cfb\u7d71\u3001\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u548c\u795e\u7d93\u808c\u8089\u75be\u75c5\u7684\u7522\u54c1\u7dda\u3002DTx Pharma\u5df2\u5f9e\u591a\u5bb6\u5168\u7403\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u6295\u8cc7\u8005\u90a3\u88e1\u7c4c\u96c6\u4e86\u8d85\u904e1.15\u5104\u7f8e\u5143\u7684\u6295\u8cc7\uff0c\u5305\u62ecRA Capital Management\u3001Access Biotechnology\u3001Surveyor Capital\uff08Citadel \u516c\u53f8\uff09\u3001Eli Lilly and Company\u3001Friedman Bioventure\u3001Viva Biotech Holdings \u4ee5\u53ca\u4f86\u81eaCMT\u7814\u7a76\u57fa\u91d1\u6703 (CMTRF) \u548c\u7f8e\u570b\u570b\u7acb\u885b\u751f\u7814\u7a76\u9662\u7b49\u7814\u7a76\u57fa\u91d1\u6703\u7684\u652f\u6301\u3002\u6b32\u4e86\u89e3\u6709\u95dc DTx Pharma \u7684\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f<a href=\"https:\/\/www.dtxpharma.com\/\" target=\"_blank\" rel=\"noopener\">www.dtxpharma.com<\/a>\u6216\u8005\u5728LinkedIn\u548cTwitter\u4e0a\u95dc\u6ce8DTx@DTxPharma\u3002<\/p>\n<p>\u95dc\u65bc Arthrosi<\/p>\n<p>Arthrosi Therapeutics\uff0cInc. \u6210\u7acb\u65bc2018\u5e74\uff0c\u7e3d\u90e8\u4f4d\u65bc\u52a0\u5229\u798f\u5c3c\u4e9e\u8056\u5730\u7259\u54e5\uff0c\u65e8\u5728\u70ba\u60a3\u6709\u75db\u98a8\u7684\u60a3\u8005\u5275\u5efa\u4e00\u7a2e\u9769\u547d\u6027\u7684\u6cbb\u7642\u9078\u64c7\uff0c\u4ee5\u964d\u4f4e\u5c3f\u9178\u6c34\u5e73\u4e26\u6e1b\u5c11\u95dc\u7bc0\u640d\u50b7\u3002\u6191\u85c9\u5176\u5ee3\u6cdb\u7684\u75db\u98a8\u9818\u57df\u6cbb\u7642\u77e5\u8b58\uff0cArthrosi \u7a4d\u7d2f\u4e86\u5168\u9762\u7684\u77e5\u8b58\u7522\u6b0a\u7d44\u5408\u548c\u4ee4\u4eba\u77da\u76ee\u76841\u671f\u548c2b\u671f\u6578\u64da\uff0c\u986f\u793a\u51fa\u884c\u696d\u9818\u5148\u7684\u7642\u6548\u7387\u548c\u5353\u8d8a\u7684\u5b89\u5168\u6027\u3002<\/p>\n<p>\u95dc\u65bc AceLink Therapeutics<\/p>\n<p>\u5275\u7acb\u65bc2018\u5e74\uff0cAceLink Therapeutics\u662f\u4e00\u5bb6\u5275\u65b0\u578b\u751f\u7269\u88fd\u85e5\u521d\u5275\u4f01\u696d\uff0c\u5c08\u6ce8\u4e8e\u958b\u767c\u5b89\u5168\u6709\u6548\u7684\u85e5\u7269\u4f86\u89e3\u6c7a\u9700\u6c42\u672a\u5f97\u5230\u6eff\u8db3\u7684\u907a\u50b3\u75be\u75c5\u3002\u516c\u53f8\u9996\u8981\u7684\u91cd\u9ede\u662f\u958b\u767c\u6cbb\u7642\u6cd5\u5e03\u745e\u6c0f\u75c5\u7684\u65b0\u7642\u6cd5\u3002\u7372\u53d6\u66f4\u591a\u4fe1\u606f\u8acb\u8a2a\u554f\uff1a<a href=\"https:\/\/www.acelinktherapeutics.com\/\" target=\"_blank\" rel=\"noopener\">www.acelinktherapeutics.com<\/a>\u3002<\/p>\n<p>\u95dc\u65bc\u7dad\u7738\u751f\u7269<\/p>\n<p>\u7dad\u7738\u751f\u7269\u662f\u4e00\u5bb6\u5c08\u6ce8\u4e8e\u773c\u79d1\u5275\u65b0\u85e5\u7814\u767c\u9818\u57df\u7684\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u64c1\u6709\u570b\u969b\u4e00\u6d41\u7684\u773c\u79d1\u5275\u65b0\u85e5\u7814\u767c\u5718\u968a\u548c\u6280\u8853\u5e73\u53f0\uff0c\u4f9d\u8a17\u81ea\u4e3b\u7814\u767c\u5df2\u7d93\u5efa\u7acb\u8d77\u5177\u6709\u5168\u7403\u7af6\u722d\u529b\u7684\u7522\u54c1\u7ba1\u7dda\u3002\u9664 VVN001\u9805\u76ee\u5916\uff0c\u7dad\u7738\u751f\u7269\u6b63\u5728\u958b\u767c VVN539\u7528\u65bc\u6cbb\u7642\u9752\u5149\u773c\u6216\u9ad8\u773c\u58d3\u75c7\uff0cVVN461\u7528\u65bc\u6cbb\u7642\u975e\u611f\u67d3\u6027\u524d\u8461\u8404\u819c\u708e\u548c\u8853\u5f8c\u708e\u75c7\u3002\u7dad\u7738\u751f\u7269\u9084\u81f4\u529b\u65bc\u767c\u73fe\u548c\u958b\u767c\u7528\u65bc\u6cbb\u7642\u5176\u4ed6\u524d\u3001\u5f8c\u7bc0\u773c\u90e8\u75be\u75c5\u7684\u65b0\u7642\u6cd5\u3002<\/p>\n<p>\u95dc\u65bc Domain Therapeutics<\/p>\n<p>Domain Therapeutics \u662f\u4e00\u5bb6\u5728\u6cd5\u570b\u548c\u52a0\u62ff\u5927\u5169\u5730\u7d93\u71df\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u767c\u73fe\u548c\u958b\u767c\u9776\u5411G\u86cb\u767d\u5076\u806f\u53d7\u9ad4 (GPCR) \u7684\u5275\u65b0\u5019\u9078\u85e5\u7269\u3002GPCR \u662f\u76ee\u524d\u6700\u91cd\u8981\u7684\u85e5\u7269\u9776\u9ede\u7a2e\u985e\u4e4b\u4e00\u3002\u516c\u53f8\u5c08\u6ce8\u4e8e\u958b\u767c\u5177\u6709\u9ad8\u50f9\u503c\u7684\u5019\u9078\u85e5\u7269\uff0c\u4ee5\u89e3\u6c7a\u514d\u75ab\u816b\u7624\u5b78\u4e2d GPCR \u4ecb\u5c0e\u7684\u514d\u75ab\u6291\u5236\u3002\u8a72\u516c\u53f8\u958b\u767c\u9ad8\u50f9\u503c\u5019\u9078\u85e5\u7269\u4ee5\u89e3\u6c7a\u514d\u75ab\u816b\u7624\u5b78\u4e2d GPCR \u4ecb\u5c0e\u7684\u514d\u75ab\u6291\u5236\u554f\u984c\uff0c\u4e26\u57282022\u5e74\u521d\u7c4c\u96c6\u4e863900\u842c\u6b50\u5143\u3002\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\uff1a<a href=\"http:\/\/www.domaintherapeutics.com\/\" target=\"_blank\" rel=\"noopener\">www.domaintherapeutics.com<\/a>\u3002<\/p>\n<p>\u95dc\u65bc HAYA Therapeutics<\/p>\n<p>HAYA Therapeutics \u662f\u4e00\u5bb6\u767c\u73fe\u4e26\u958b\u767c\u5275\u65b0\u7d44\u7e54\u548c\u7d30\u80de\u9078\u64c7\u6027\u57fa\u56e0\u7d44\u85e5\u7269\u7cbe\u6e96\u85e5\u7269\u516c\u53f8\u3002\u516c\u53f8\u5c08\u6ce8\u65bc\u7e96\u7dad\u5316\u548c\u5176\u4ed6\u75be\u75c5\u904e\u7a0b\u7684\u95dc\u9375\u7d44\u7e54\u548c\u7d30\u80de\u7279\u7570\u6027\u9a45\u52d5\u56e0\u7d20\u2014\u2014\u4eba\u985e\u57fa\u56e0\u7d44\u300c\u6697\u7269\u8cea\u300d\u4e2d\u7684\u9577\u975e\u7de8\u78bc RNA (lncRNAs)\uff0c\u4ee5\u8b58\u5225\u65b0\u9776\u9ede\u548c\u5019\u9078\u85e5\u7269\u3002\u9019\u4e9b\u9776\u9ede\u548c\u85e5\u7269\u5177\u6709\u6bd4\u73fe\u6709\u6cbb\u7642\u66f4\u5927\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u3002<\/p>\n<p>\u95dc\u65bc\u7dad\u4e9e\u751f\u7269<\/p>\n<p>\u7dad\u4e9e\u751f\u7269 (01873. 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