{"id":13088,"date":"2023-06-19T12:47:00","date_gmt":"2023-06-19T04:47:00","guid":{"rendered":"https:\/\/www.franchise.com.hk\/sirnaomics%e6%8e%a8%e9%80%b2stp705%e6%b2%bb%e7%99%82%e9%b1%97%e7%8b%80%e7%b4%b0%e8%83%9e%e5%8e%9f%e4%bd%8d%e7%99%8c%e9%80%b2%e5%85%a5%e5%be%8c%e6%9c%9f%e8%87%a8%e5%ba%8a%e7%a0%94%e7%99%bc%e9%9a%8e\/13088"},"modified":"2023-06-19T12:47:00","modified_gmt":"2023-06-19T04:47:00","slug":"sirnaomics%e6%8e%a8%e9%80%b2stp705%e6%b2%bb%e7%99%82%e9%b1%97%e7%8b%80%e7%b4%b0%e8%83%9e%e5%8e%9f%e4%bd%8d%e7%99%8c%e9%80%b2%e5%85%a5%e5%be%8c%e6%9c%9f%e8%87%a8%e5%ba%8a%e7%a0%94%e7%99%bc%e9%9a%8e","status":"publish","type":"post","link":"https:\/\/www.franchise.com.hk\/zh-hans\/sirnaomics%e6%8e%a8%e9%80%b2stp705%e6%b2%bb%e7%99%82%e9%b1%97%e7%8b%80%e7%b4%b0%e8%83%9e%e5%8e%9f%e4%bd%8d%e7%99%8c%e9%80%b2%e5%85%a5%e5%be%8c%e6%9c%9f%e8%87%a8%e5%ba%8a%e7%a0%94%e7%99%bc%e9%9a%8e\/13088","title":{"rendered":"Sirnaomics\u63a8\u9032STP705\u6cbb\u7642\u9c57\u72c0\u7d30\u80de\u539f\u4f4d\u764c\u9032\u5165\u5f8c\u671f\u81e8\u5e8a\u7814\u767c\u968e\u6bb5"},"content":{"rendered":"<p><span class=\"legendSpanClass\">\u9999\u6e2f\u3001\u99ac\u91cc\u862d\u5dde\u5fb7\u570b\u57ce\u548c\u4e2d\u570b\u8607\u5dde<\/span><span class=\"legendSpanClass\">2023\u5e746\u670819\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; <span><span>Sirnaomics Ltd. <\/span><span>\uff08<\/span>\u300c\u672c\u516c\u53f8\u300d\uff0c\u80a1\u4efd\u4ee3\u865f\uff1a2257.HK\uff0c\u9023\u540c\u5176\u9644\u5c6c\u516c\u53f8\uff0c\u7d71\u7a31\u300c\u672c\u96c6\u5718\u300d\u6216\u300cSirnaomics\u300d\uff09\uff0c\u4e00\u5bb6\u884c\u696d\u9818\u5148\u7684\u5c08\u6ce8\u65bc\u63a2\u7d22\u53ca\u958b\u767c RNAi\u7642\u6cd5\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\u3002<\/span>Sirnaomics \u4eca\u5929\u5ba3\u4f48\u65bc\u4e8c\u671f\u81e8\u5e8a\u7d50\u675f\u6703\u8b70\u8207\u7f8e\u570b\u98df\u54c1\u85e5\u7269\u7ba1\u7406\u5c40 (FDA) \u5206\u4eab\u4e86\u4ee4\u4eba\u9f13\u821e\u7684IIa\u53caIIb\u671f\u81e8\u5e8a\u6578\u64da\u5f8c\uff0c\u672c\u96c6\u5718\u7528\u65bc\u6cbb\u7642\u539f\u4f4d\u9c57\u72c0\u7d30\u80de\u764c (isSCC) \u7684\u5019\u9078\u7522\u54c1 STP705 \u9032\u5165\u5f8c\u671f\u81e8\u5e8a\u7814\u767c\u968e\u6bb5\u3002\u7531\u65bc Sirnaomics \u63d0\u4f9b\u7684\u6709\u6548\u6578\u64da\u53ca\u9c57\u72c0\u7d30\u80de\u764c (SCC) \u75c5\u8b8a\u7684\u5ee3\u6cdb\u6d41\u884c\uff0c\u7f8e\u570b FDA \u70ba\u672c\u96c6\u5718\u9032\u4e00\u6b65\u63a8\u9032 STP705\u5f8c\u671f\u81e8\u5e8a\u7814\u767c\u5de5\u4f5c\u63d0\u4f9b\u4e86\u6307\u5c0e\u5efa\u8b70\u3002<\/p>\n<p>Sirnaomics \u76ee\u524d\u5df2\u5728\u7a4d\u6975\u63a8\u9032 STP705\u7528\u65bc\u6cbb\u7642 isSCC \u7684\u78ba\u8b49\u6027\u81e8\u5e8a\u7814\u7a76\u3002<span>\u516c\u53f8<\/span>\u57282023\u5e74\u63a8\u9032\u4e00\u9805\u9078\u5b9a\u5291\u91cf\u3001\u96a8\u6a5f\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u7684\u78ba\u8b49\u6027\u81e8\u5e8a\u7814\u7a76\u4f5c\u70ba\u5927\u578b\u2162\u671f\u81e8\u5e8a\u7814\u7a76\u4e2d\u7684\u4e00\u500b\u90e8\u5206\uff0c\u5176\u6b63\u9762\u7684\u6578\u64da\u5c07\u70ba\u5b8c\u6210\u9019\u4e00\u5927\u578b\u8a3b\u518aIII\u671f\u81e8\u5e8a\u8a66\u9a57\u5960\u5b9a\u57fa\u790e\u3002Sirnaomics \u540c\u6642\u4ea6\u5728\u7e7c\u7e8c\u63a8\u9032 STP705\u7528\u65bc\u6cbb\u7642\u57fa\u5e95\u7d30\u80de\u764c (BCC) \u7684\u76f8\u95dc\u7814\u7a76\uff0c\u9019\u5c07\u6210\u70ba\u4e0b\u4e00\u500b\u9032\u5165\u5f8c\u671f\u7814\u767c\u968e\u6bb5\u7684\u5019\u9078\u7522\u54c1\uff0c\u76ee\u524d\u6b63\u5728\u7b49\u5f85\u7f8e\u570b FDA \u7684\u5be9\u67e5\u3002<\/p>\n<p>STP705\u5df2\u7d93\u5728100\u591a\u4f4d\u53d7\u8a66\u8005\u4e2d\u5c31\u6cbb\u7642 isSCC \u53ca BCC \u9032\u884c\u4e86\u81e8\u5e8a\u8a66\u9a57\u3002\u6b64\u524d\u91dd\u5c0d\u9019\u5169\u7a2e\u764c\u75c7\u9069\u61c9\u75c7\u9032\u884c\u7684\u81e8\u5e8a\u7814\u7a76\u5b89\u5168\u6027\u6578\u64da\u8868\u660e\uff0cSTP705\u5177\u5099\u5b89\u5168\u6027\uff0c\u4e14\u6c92\u67093\u7d1a\u6216\u66f4\u9ad8\u7684\u4e0d\u826f\u4e8b\u4ef6\u3002\u521d\u6b65\u7642\u6548\u6578\u64da\u986f\u793a\uff0c\u5927\u591a\u6578\u6cbb\u7642\u7d44\u7684\u764c\u7d30\u80de\u5df2\u5be6\u73fe\u7d44\u7e54\u5b78\u6e05\u9664\u3002<\/p>\n<p>Sirnaomics \u5275\u59cb\u4eba\u3001\u8463\u4e8b\u6703\u4e3b\u5e2d\u3001\u57f7\u884c\u8463\u4e8b\u3001\u7e3d\u88c1\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u9678\u967d\u535a\u58eb\u8868\u793a\uff1a\u300c\u5c07 STP705\u7528\u65bc\u6cbb\u7642\u9c57\u72c0\u7d30\u80de\u539f\u4f4d\u764c\u63a8\u9032\u81f3\u5f8c\u671f\u81e8\u5e8a\u7814\u767c\u968e\u6bb5\u662f\u6211\u5011\u81e8\u5e8a\u9805\u76ee\u53ca\u76ae\u819a\u75c5\u5b78\/\u816b\u7624\u5b78\u61c9\u7528\u7684\u4e00\u500b\u91cd\u8981\u91cc\u7a0b\u7891\u3002\u6839\u64da\u300a\u7f8e\u570b\u91ab\u5b78\u6703\u76ae\u819a\u75c5\u96dc\u8a8c\u300b(JAMA Dermatology) 2020 \u5e74\u7684\u7814\u7a76\u5831\u544a\u986f\u793a\uff0c\u5728 isSCC \u60a3\u8005\u4e2d\uff0c\u7537\u6027\u60a3\u8005\u767c\u751f\u4fb5\u5165\u6027 SCC \u7684\u7d2f\u7a4d\u98a8\u96aa\u70ba11.7%\uff0c\u5973\u6027\u60a3\u8005\u70ba6.9%\u3002\u9452\u65bc SCC \u75c5\u8b8a\u7684\u5ee3\u6cdb\u6d41\u884c\u548c\u9f90\u5927\u672a\u7372\u6eff\u8db3\u7684\u91ab\u7642\u9700\u6c42\uff0cSirnaomics \u81f4\u529b\u65bc\u8fce\u63a5\u6311\u6230\uff0c\u4e26\u70ba\u6b64\u7814\u767c\u57fa\u65bcRNAi\u6280\u8853\u7684\u65b0\u578b\u7642\u6cd5\u7522\u54c1\u3002\u300d<\/p>\n<p>Sirnaomics \u57f7\u884c\u8463\u4e8b\u517c\u9996\u5e2d\u91ab\u52d9\u5b98 <span class=\"xn-person\">Michael Molyneaux<\/span> \u535a\u58eb\u8868\u793a\uff1a\u300c\u6839\u64da\u8207 FDA \u8209\u884c\u7684 B \u985e\u6703\u8b70\u6307\u5c0e\u5efa\u8b70\uff0c\u6211\u5011\u76ee\u524d\u5c0d\u65bc\u63a8\u9032 STP705\u4f5c\u70ba\u7528\u65bc\u6cbb\u7642 isSCC \u7684\u5275\u65b0\u85e5\u7269\u9032\u884c\u5f8c\u671f\u7814\u767c\u5df2\u5efa\u7acb\u660e\u78ba\u7684\u8def\u5f91\u3002\u6211\u5011\u7684\u6578\u64da\u5df2\u7d93\u8b49\u5be6\u4e86 STP705\u6cbb\u7642 isSCC \u51fa\u8272\u7684\u5b89\u5168\u6027\u53ca\u6709\u6548\u6027\uff0c\u4e14\u6211\u5011\u5c0d\u65bc\u8a72\u9805\u76ee\u9032\u5165\u5f8c\u671f\u7814\u767c\u968e\u6bb5\u975e\u5e38\u671f\u5f85\u3002\u300d<\/p>\n<p>\u95dc\u65bc STP705<br \/>Sirnaomics \u7684\u4e3b\u8981\u5019\u9078\u7522\u54c1 STP705\u662f\u4e00\u7a2e siRNA\uff08\u5c0f\u5e72\u64fe\u6838\u9178\uff09\u7642\u6cd5\uff0c\u5229\u7528\u96d9\u9776\u5411\u6291\u5236\u7279\u6027\u548c\u589e\u5f37\u7684\u591a\u80bd\u7d0d\u7c73\u9846\u7c92(PNP)\u905e\u9001\u4f86\u76f4\u63a5\u6572\u4f4e TGF-\u03b21\u548cCOX-2\u57fa\u56e0\u8868\u9054\u3002\u8a72\u5019\u9078\u7522\u54c1\u5df2\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40 (FDA) \u548c\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40 (NMPA) \u7684\u591a\u9805 IND \u6279\u51c6\uff0c\u5305\u62ec\u7528\u65bc\u6cbb\u7642\u81bd\u7ba1\u764c\u3001\u975e\u9ed1\u8272\u7d20\u7624\u76ae\u819a\u764c\u548c\u589e\u751f\u6027\u7622\u75d5\u3002\u76ee\u524d STP705 \u6709\u4e09\u9805\u512a\u5148\u63a8\u9032\u7684\u7522\u54c1\u7ba1\u7dda\uff1a \u4e00\u9805\u91dd\u5c0d\u9c57\u72c0\u7d30\u80de\u539f\u4f4d\u764c (isSCC) \u7684\u5f8c\u671f\u81e8\u5e8a\u8a66\u9a57\u3001\u4e00\u9805\u6cbb\u7642\u57fa\u5e95\u7d30\u80de\u764c (BCC) \u7684\u5df2\u5b8c\u6210\u7684II\u671f\u81e8\u5e8a\u8a66\u9a57\u4ee5\u53ca\u4e00\u9805\u7528\u65bc\u8102\u80aa\u91cd\u5851\u7684I\u671f\u81e8\u5e8a\u8a66\u9a57\u3002\u6b64\u5916\uff0c\u5728\u6cbb\u7642\u5176\u4ed6\u9069\u61c9\u75c7\u65b9\u9762\uff0cSTP705\u5df2\u7372\u5f97\u4e86\u6cbb\u7642\u81bd\u7ba1\u764c (CCA) \u548c\u539f\u767c\u6027\u786c\u5316\u6027\u81bd\u7ba1\u708e (PSC) \u7684\u5b64\u5152\u85e5\u8cc7\u683c\u3002<\/p>\n<p>\u95dc\u65bcSirnaomics Ltd. \uff08\u80a1\u4efd\u4ee3\u865f: 2257\uff09<br \/>Sirnaomics\u662f\u4e00\u5bb6 RNA \u7642\u6cd5\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u516c\u53f8\u5019\u9078\u7522\u54c1\u8655\u65bc\u81e8\u5e8a\u53ca\u81e8\u5e8a\u524d\u968e\u6bb5\uff0c\u5c08\u6ce8\u65bc\u63a2\u7d22\u53ca\u958b\u767c\u5275\u65b0\u85e5\u7269\uff0c\u7528\u65bc\u6cbb\u7642\u5177\u6709\u91ab\u7642\u9700\u6c42\u53ca\u9f90\u5927\u5e02\u5834\u6a5f\u6703\u7684\u9069\u61c9\u75c7\u3002Sirnaomics \u662f\u9996\u5bb6\u65bc\u4e9e\u6d32\u548c\u7f8e\u570b\u5747\u64c1\u6709\u91cd\u8981\u5e02\u5834\u5730\u4f4d\u7684\u81e8\u5e8a\u968e\u6bb5 RNA \u7642\u6cd5\u751f\u7269\u88fd\u85e5\u516c\u53f8\u3002\u6191\u85c9\u5176\u5c08\u6709\u7684\u905e\u9001\u6280\u8853\uff1a \u591a\u80bd\u7d0d\u7c73\u9846\u7c92\u905e\u9001\u5e73\u53f0\u548c\u7b2c\u4e8c\u4ee3 GalNAc \u5076\u806f\u7269\u905e\u9001\u5e73\u53f0\uff0c\u672c\u96c6\u5718\u5df2\u5efa\u7acb\u975e\u5e38\u8c50\u5bcc\u7684\u5019\u9078\u85e5\u7269\u7ba1\u7dda\u3002\u96a8\u8457\u516c\u53f8 STP705 \u548c STP707 \u7684\u81e8\u5e8a\u9805\u76ee\u53d6\u5f97\u591a\u9805\u6210\u529f\uff0cSirnaomics \u76ee\u524d\u5728\u63a8\u9032\u816b\u7624\u6cbb\u7642\u7684 RNAi \u85e5\u7269\u65b9\u9762\u8655\u65bc\u570b\u969b\u9818\u5148\u5730\u4f4d\u3002STP122G\u662f\u9996\u6b3e\u9032\u5165\u81e8\u5e8a\u7814\u767c\u968e\u6bb5\u7684 GalAhead\u2122 \u6280\u8853\u5019\u9078\u85e5\u7269\u3002\u96a8\u8457 Sirnaomics \u81e8\u5e8a\u751f\u7522\u8a2d\u65bd\u7684\u5efa\u7acb\uff0c\u672c\u96c6\u5718\u76ee\u524d\u6b63\u5728\u5be6\u73fe\u5f9e\u751f\u7269\u79d1\u6280\u516c\u53f8\u5411\u751f\u7269\u88fd\u85e5\u516c\u53f8\u7684\u8e8d\u9032\u3002\u5982\u6b32\u4e86\u89e3\u66f4\u591a\u95dc\u65bc\u516c\u53f8\u8cc7\u8a0a\uff0c\u53ef\u700f\u89bd\uff1a<a href=\"https:\/\/www.sirnaomics.com\/\" target=\"_blank\" rel=\"noopener\">www.sirnaomics.com<\/a>\u3002<\/p>","protected":false},"excerpt":{"rendered":"<p>\u9999\u6e2f\u3001\u99ac\u91cc\u862d\u5dde\u5fb7\u570b\u57ce\u548c\u4e2d\u570b\u8607\u5dde2023\u5e746\u670819\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; Sirnaomics Ltd. \uff08\u300c\u672c\u516c\u53f8\u300d\uff0c\u80a1\u4efd\u4ee3\u865f\uff1a2257.HK\uff0c\u9023\u540c\u5176\u9644\u5c6c\u516c\u53f8\uff0c\u7d71\u7a31\u300c\u672c\u96c6\u5718\u300d\u6216\u300cSirnaomics\u300d\uff09\uff0c\u4e00\u5bb6\u884c\u696d\u9818\u5148\u7684\u5c08\u6ce8\u65bc\u63a2\u7d22\u53ca\u958b\u767c 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