{"id":12876,"date":"2023-06-03T00:00:00","date_gmt":"2023-06-02T16:00:00","guid":{"rendered":"https:\/\/www.franchise.com.hk\/%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%ae%a3%e4%bd%88%e8%80%90%e7%ab%8b%e5%85%8b%e7%ac%ac%e4%ba%8c%e6%ac%a1%e8%a2%ab%e5%9c%8b%e5%ae%b6%e8%97%a5%e5%93%81%e7%9b%a3%e7%9d%a3%e7%ae%a1%e7%90%86\/12876"},"modified":"2023-06-03T00:00:00","modified_gmt":"2023-06-02T16:00:00","slug":"%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%ae%a3%e4%bd%88%e8%80%90%e7%ab%8b%e5%85%8b%e7%ac%ac%e4%ba%8c%e6%ac%a1%e8%a2%ab%e5%9c%8b%e5%ae%b6%e8%97%a5%e5%93%81%e7%9b%a3%e7%9d%a3%e7%ae%a1%e7%90%86","status":"publish","type":"post","link":"https:\/\/www.franchise.com.hk\/zh-hans\/%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%ae%a3%e4%bd%88%e8%80%90%e7%ab%8b%e5%85%8b%e7%ac%ac%e4%ba%8c%e6%ac%a1%e8%a2%ab%e5%9c%8b%e5%ae%b6%e8%97%a5%e5%93%81%e7%9b%a3%e7%9d%a3%e7%ae%a1%e7%90%86\/12876","title":{"rendered":"\u4fe1\u9054\u751f\u7269\u5ba3\u4f48\u8010\u7acb\u514b\u00ae\u7b2c\u4e8c\u6b21\u88ab\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u7d0d\u5165\u7a81\u7834\u6027\u6cbb\u7642\u85e5\u7269\u54c1\u7a2e\uff0c\u6cbb\u7642SDH\u7f3a\u9677\u578bGIST"},"content":{"rendered":"

\u7f8e\u570b\u7f85\u514b\u7dad\u723e\u548c\u4e2d\u570b\u8607\u5dde<\/span>2023\u5e746\u67082\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — <\/span>\u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u80a1\u7968\u4ee3\u78bc\uff1a<\/span>01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u5275\u65b0\u85e5\u7269\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u4f48\uff0c\u4fe1\u9054\u751f\u7269\u8207\u4e9e\u76db\u91ab\u85e5\u5408\u4f5c\u7684\u539f\u52751\u985e\u65b0\u85e5\u5967\u96f7\u5df4\u66ff\u5c3c\uff08\u66fe\u7528\u540d\u8010\u514b\u66ff\u5c3c\uff1b\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b\u00ae\uff09\u5df2\u88ab\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u7d0d\u5165\u7a81\u7834\u6027\u6cbb\u7642\u85e5\u7269\uff08BTD\uff09\u54c1\u7a2e\u540d\u55ae\uff0c\u6cbb\u7642\u65e2\u5f80\u7d93\u904e\u4e00\u7dda\u6cbb\u7642\u7684\u7425\u73c0\u9178\u812b\u6c2b\u9176\uff08succinate dehydrogenase, SDH\uff09\u7f3a\u9677\u578b\u80c3\u8178\u9053\u9593\u8cea\u7624\uff08GIST\uff09\u60a3\u8005\u3002<\/span><\/p>\n

\u4e00\u9805\u5728\u4e2d\u570b\u9032\u884c\u7684\u81e8\u5e8a<\/span>Ib\/II\u671f\u7814\u7a76\u6700\u65b0\u6578\u64da\u986f\u793a\uff0c\u8010\u7acb\u514b\u00ae\u5728SDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u4e2d\u7684\u81e8\u5e8a\u7372\u76ca\u7387\uff08CBR\uff09\u9ad8\u905493.8%[1]\uff0c\u8a72\u81e8\u5e8a\u7814\u7a76\u4e5f\u56e0\u6b64\u9023\u7e8c\u5169\u5e74\u5165\u9078\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\u5c55\u793a\u3002<\/span><\/p>\n

\u8010\u7acb\u514b<\/span>\u00ae<\/span>\u662f\u4e2d\u570b\u9996\u500b\u4e14\u552f\u4e00\u7372\u6279\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3<\/span>BCR-ABL\u6291\u5236\u5291\uff0c\u5728\u4e2d\u570b\u7684\u5546\u696d\u5316\u63a8\u5ee3\u7531\u4e9e\u76db\u91ab\u85e5\u548c\u4fe1\u9054\u751f\u7269\u5171\u540c\u8ca0\u8cac\u30022021\u5e7411\u6708\uff0cNMPA\u901a\u904e\u512a\u5148\u5be9\u8a55\u5be9\u6279\u7a0b\u5e8f\u9644\u689d\u4ef6\u6279\u51c6\u8010\u7acb\u514b\u00ae\u4e0a\u5e02\u7533\u8acb\uff0c\u7528\u65bc\u6cbb\u7642\u4efb\u4f55TKI\u8010\u85e5\uff0c\u4e26\u63a1\u7528\u7d93\u5145\u5206\u9a57\u8b49\u7684\u6aa2\u6e2c\u65b9\u6cd5\u8a3a\u65b7\u70ba\u4f34\u6709T315I\u7a81\u8b8a\u7684\u6162\u6027\u671f\u6162\u6027\u9ad3\u6027\u767d\u8840\u75c5\uff08CML-CP\uff09\u6216\u52a0\u901f\u671fCML\uff08CML-AP\uff09\u7684\u6210\u4eba\u60a3\u8005\u3002<\/span><\/p>\n

\u9019\u662f\u8010\u7acb\u514b<\/span>\u00ae<\/span>\u7b2c\u4e8c\u6b21\u7372<\/span>CDE\u7d0d\u5165\u7a81\u7834\u6027\u6cbb\u7642\u54c1\u7a2e\u3002\u6b64\u524d\u65bc2021\u5e743\u6708\uff0c\u8a72\u54c1\u7a2e\u9996\u6b21\u7372\u7d0d\u5165\u7a81\u7834\u6027\u6cbb\u7642\u54c1\u7a2e\uff0c\u7528\u65bc\u6cbb\u7642\u4e00\u4ee3\u548c\u4e8c\u4ee3\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08TKI\uff09\u8010\u85e5\u548c\/\u6216\u4e0d\u8010\u53d7\u7684\u6162\u6027\u671f\u6162\u6027\u9ad3\u6027\u767d\u8840\u75c5\uff08CML-CP\uff09\u60a3\u8005\uff0c\u8a72\u9069\u61c9\u75c7\u7684\u4e0a\u5e02\u7533\u8acb\u65bc2022\u5e747\u6708\u7372NMPA\u53d7\u7406\u4e26\u88ab\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u7a0b\u5e8f\uff0c\u5c07\u652f\u6301\u8010\u7acb\u514b\u00ae\u7372\u5f97\u5b8c\u5168\u6279\u51c6\u3002<\/span><\/p>\n

\u4fe1\u9054\u751f\u7269\u9ad8\u7d1a\u526f\u7e3d\u88c1\u5468\u8f1d\u535a\u58eb<\/span>\u8868\u793a\uff1a<\/span>\u300c<\/span>\u6211\u5011\u5f88\u9ad8\u8208\u8010\u7acb\u514b<\/span>\u00ae<\/span>\u7372\u5f97\u7b2c\u4e8c\u9805\u7a81\u7834\u6027\u6cbb\u7642\u85e5\u7269\u7684\u8a8d\u5b9a\uff0c\u671f\u5f85\u5176\u5728\u8840\u6db2\u7624\u4e4b\u5916\u7684\u6f5b\u5728\u81e8\u5e8a\u6f5b\u529b\u548c\u50f9\u503c\uff0c\u4f7f\u5f97\u66f4\u5ee3\u95ca\u7684\u5be6\u9ad4\u7624\u60a3\u8005\u56e0\u6b64\u7372\u76ca\u3002\u4fe1\u9054\u751f\u7269\u5c07\u79c9\u6301\u300e\u958b\u767c\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8cea\u91cf\u751f\u7269\u85e5<\/span>\u300f<\/span>\u7684\u4f7f\u547d\uff0c\u70ba\u66f4\u591a\u60a3\u8005\u548c\u5bb6\u5ead\u5e36\u53bb\u5e0c\u671b\u3002<\/span>\u300d<\/span>\u00a0<\/span><\/p>\n

\u7a81\u7834\u6027\u6cbb\u7642\u85e5\u7269\u8cc7\u683c\u8a8d\u5b9a\u662f\u70ba\u4e86\u52a0\u5feb\u958b\u767c\u91dd\u5c0d\u56b4\u91cd\u75be\u75c5\u3001\u4e14\u5df2\u5728\u521d\u6b65\u81e8\u5e8a\u8a66\u9a57\u4e2d\u986f\u793a\u7642\u6548\u6216\u5b89\u5168\u6027\u65b9\u9762\u986f\u8457\u512a\u65bc\u73fe\u6709\u6cbb\u7642\u624b\u6bb5\u7684\u65b0\u85e5\u800c\u8a2d\u8a08\u7684\u3002\u7372\u5f97\u7a81\u7834\u6027\u6cbb\u7642\u85e5\u7269\u8a8d\u5b9a\u80fd\u5920\u4f7f\u8a72\u85e5\u5728\u7814\u767c\u904e\u7a0b\u4e2d\u8207<\/span>CDE\u5bc6\u5207\u4ea4\u6d41\u3001\u7372\u5f97\u6307\u5c0e\uff0c\u5f9e\u800c\u52a0\u5feb\u65b0\u85e5\u4e0a\u5e02\uff0c\u66f4\u65e9\u89e3\u6c7a\u4e2d\u570b\u75c5\u60a3\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u3002\u53ef\u9ede\u64ca<\/span>\u9019\u88e1<\/span><\/a>\u67e5\u770b\u5df2\u7d0d\u5165\u7a81\u7834\u6027\u6cbb\u7642\u54c1\u7a2e\u540d\u55ae<\/span>\u3002<\/span><\/p>\n

\u95dc\u65bc\u80c3\u8178\u9053\u9593\u8cea\u7624\uff08<\/span>GIST<\/span>\uff09<\/span><\/p>\n

GIST<\/span>\u662f\u4e00\u7a2e\u8d77\u6e90\u65bc\u80c3\u8178\u9053\u9593\u8449\u7d44\u7e54\u7684\u816b\u7624\uff0c\u5927\u90e8\u5206\u7684<\/span>GIST<\/span>\u60a3\u8005\u4f34\u6709<\/span>KIT<\/span>\u6216<\/span>PDGFRA<\/span>\u57fa\u56e0\u7a81\u8b8a\u3002<\/span>TKI<\/span>\u7684\u51fa\u73fe\uff0c\u6539\u5584\u4e86\u9019\u985e<\/span>GIST<\/span>\u60a3\u8005\u7684\u9810\u5f8c\u3002\u7136\u800c\uff0c\u5728<\/span>SDH<\/span>\u7f3a\u9677\u578b<\/span>GIST<\/span>\u9019\u4e00\u7f55\u898b\u7684\u4e9e\u578b<\/span>GIST<\/span>\u6cbb\u7642\u9818\u57df\uff0c\u537b\u5b58\u5728\u5de8\u5927\u7684\u3001\u672a\u88ab\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u3002\u64da\u6089\uff0c<\/span>SDH<\/span>\u7f3a\u9677\u578b<\/span>GIST<\/span>\u60a3\u8005\u901a\u5e38\u5c0d\u73fe\u6709\u7684<\/span>TKI<\/span>\u85e5\u7269\u4e0d\u654f\u611f\uff0c\u96d6\u7136\u65e9\u671f\u7684\u5c40\u9650\u6027\u60a3\u8005\u53ef\u901a\u904e\u624b\u8853\u6cbb\u7642\uff0c\u4f46\u5927\u90e8\u5206\u60a3\u8005\u4ecd\u7136\u6703\u5fa9\u767c[<\/span>2]-[6]<\/span>\u3002\u76ee\u524d\u5c1a\u7121\u91dd\u5c0d\u5fa9\u767c\u548c\u665a\u671f<\/span>SDH<\/span>\u7f3a\u9677\u578b<\/span>GIST<\/span>\u60a3\u8005\u7684\u6a19\u6e96\u6cbb\u7642\u65b9\u6848[2]-[6]<\/span>\uff0c<\/span>5<\/span>\u5e74\u7121\u4e8b\u4ef6\u751f\u5b58\u7387\uff08<\/span>EFS<\/span>\uff09\u50c5\u70ba<\/span>24%[5]<\/span>\u3002<\/span><\/p>\n

\u95dc\u65bc\u8010\u7acb\u514b<\/span>\u00ae<\/span><\/p>\n

\u8010\u7acb\u514b<\/span>\u00ae<\/span>\u662f\u4e9e\u76db\u91ab\u85e5\u539f\u5275<\/span>1<\/span>\u985e\u65b0\u85e5\uff0c\u70ba\u53e3\u670d\u7b2c\u4e09\u4ee3<\/span>BCR-ABL<\/span>\u6291\u5236\u5291\uff0c\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3<\/span>BCR-ABL<\/span>\u9776\u5411\u8010\u85e5<\/span>CML<\/span>\u6cbb\u7642\u85e5\u7269\uff0c\u5c0d<\/span>BCR-ABL<\/span>\u4ee5\u53ca\u5305\u62ec<\/span>T315I<\/span>\u7a81\u8b8a\u5728\u5167\u7684\u591a\u7a2e<\/span>BCR-ABL<\/span>\u7a81\u8b8a\u9ad4\u6709\u7a81\u51fa\u6548\u679c\uff0c\u7372\u570b\u5bb6<\/span>\u300c<\/span>\u91cd\u5927\u65b0\u85e5\u5275\u88fd<\/span>\u300d<\/span>\u5c08\u9805\u652f\u6301\u3002<\/span><\/p>\n

2021<\/span>\u5e74<\/span>11<\/span>\u6708\uff0c<\/span>NMPA<\/span>\u901a\u904e\u512a\u5148\u5be9\u8a55\u5be9\u6279\u7a0b\u5e8f\u9644\u689d\u4ef6\u6279\u51c6\u8010\u7acb\u514b<\/span>\u00ae<\/span>\u4e0a\u5e02\u7533\u8acb\uff0c\u7528\u65bc\u6cbb\u7642\u7528\u65bc\u4efb\u4f55\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\u8010\u85e5\uff0c\u4e26\u63a1\u7528\u7d93\u5145\u5206\u9a57\u8b49\u7684\u6aa2\u6e2c\u65b9\u6cd5\u8a3a\u65b7\u70ba\u4f34\u6709<\/span>T315I <\/span>\u7a81\u8b8a\u7684\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u6162\u6027\u671f<\/span> (CML-CP) <\/span>\u6216\u52a0\u901f\u671f<\/span> (CML-AP) <\/span>\u7684\u6210\u5e74\u60a3\u8005\uff1b\u76ee\u524d\uff0c\u8010\u7acb\u514b<\/span>\u00ae<\/span>\u7684\u8a72\u9069\u61c9\u75c7\u5df2\u88ab\u6210\u529f\u7d0d\u5165\u300a\u570b\u5bb6\u57fa\u672c\u91ab\u7642\u4fdd\u96aa\u3001\u5de5\u50b7\u4fdd\u96aa\u548c\u751f\u80b2\u4fdd\u96aa\u85e5\u54c1\u76ee\u9304\uff08<\/span>2022<\/span>\u5e74\uff09\u300b\u3002<\/span>2022<\/span>\u5e74<\/span>7<\/span>\u6708\uff0c<\/span>NMPA<\/span>\u53d7\u7406<\/span>\u8010\u7acb\u514b<\/span>\u00ae<\/span>\u7684<\/span>\u4e0a\u5e02<\/span>\u7533\u8acb\u4e26\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u7a0b\u5e8f\uff0c\u7528\u65bc\u6cbb\u7642\u4e00\u4ee3\u548c\u4e8c\u4ee3\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08<\/span>TKIs<\/span>\uff09\u8010\u85e5\u548c<\/span>\/<\/span>\u6216\u4e0d\u8010\u53d7\u7684\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u6162\u6027\u671f\uff08<\/span>CML-CP<\/span>\uff09\u60a3\u8005\uff0c\u5c07\u652f\u6301\u8010\u7acb\u514b<\/span>\u00ae<\/span>\u7372\u5f97\u5b8c\u5168\u6279\u51c6\u3002<\/span><\/p>\n

\u800c\u5728\u6d77\u5916\uff0c\u8a72\u54c1\u7a2e\u65bc<\/span>2019<\/span>\u5e74<\/span>7<\/span>\u6708\u7372<\/span>FDA<\/span>\u81e8\u5e8a\u8a66\u9a57\u8a31\u53ef\uff0c\u76f4\u63a5\u9032\u5165<\/span>Ib<\/span>\u671f\u81e8\u5e8a\u7814\u7a76\uff1b\u5176\u81e8\u5e8a\u8a66\u9a57\u9032\u5c55\u81ea<\/span>2018<\/span>\u5e74\u958b\u59cb\uff0c\u9023\u7e8c\u4e94\u5e74\u5165\u9078\u7f8e\u570b\u8840\u6db2\u5b78\u6703\uff08<\/span>ASH<\/span>\uff09\u5e74\u6703\u53e3\u982d\u5831\u544a\uff0c\u4e26\u69ae\u7372<\/span>2019 ASH<\/span>\u5e74\u6703<\/span>\u300c<\/span>\u6700\u4f73\u7814\u7a76<\/span>\u300d<\/span>\u7684\u63d0\u540d\u3002\u76ee\u524d\uff0c\u8010\u7acb\u514b<\/span>\u00ae<\/span>\u5171\u7372<\/span>1<\/span>\u9805\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08<\/span>FDA<\/span>\uff09\u5be9\u8a55\u5feb\u901f\u901a\u9053\u8cc7\u683c\uff1b<\/span>4<\/span>\u9805\u7f8e\u570b<\/span>FDA<\/span>\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff0c\u9069\u61c9\u75c7\u5206\u5225\u70ba<\/span>CML<\/span>\uff0c\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08<\/span>ALL<\/span>\uff09\u548c\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08<\/span>AML<\/span>\uff09\u548c\u80c3\u8178\u9053\u9593\u8cea\u7624\uff08<\/span>GIST<\/span>\uff09\uff1b\u9084\u7372\u4e00\u9805<\/span>1<\/span>\u9805\u6b50\u6d32\u85e5\u54c1\u7ba1\u7406\u5c40\uff08<\/span>EMA<\/span>\uff09\u7684\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff0c\u9069\u61c9\u75c7\u70ba<\/span>CML<\/span>\u3002<\/span><\/p>\n

2021<\/span>\u5e74<\/span>7<\/span>\u6708\uff0c\u4e9e\u76db\u91ab\u85e5\uff08<\/span>6855.HK<\/span>\uff09<\/span>\u8207\u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\uff08<\/span>1801.HK<\/span>\uff09\u9054\u6210\u5728\u4e2d\u570b\u5e02\u5834\u5c31\u8010\u7acb\u514b<\/span>\u00ae<\/span>\u5171\u540c\u958b\u767c\u548c\u5171\u540c\u5546\u696d\u5316\u63a8\u5ee3\u7684\u6230\u7565\u5408\u4f5c\u3002<\/span><\/p>\n

*<\/span>\u6ce8<\/span>\u00a0\u8010\u7acb\u514b<\/span>\u00ae<\/span>\u70ba\u4e9e\u76db\u91ab\u85e5\u7684\u8a3b\u518a\u5546\u6a19<\/span><\/p>\n

\u95dc\u65bc\u4fe1\u9054\u751f\u7269<\/span><\/p>\n

\u300c\u59cb\u65bc\u4fe1\uff0c\u9054\u65bc\u884c\u300d\uff0c\u958b\u767c\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8cea\u91cf\u751f\u7269\u85e5\uff0c\u662f\u4fe1\u9054\u751f\u7269\u7684\u7406\u60f3\u548c\u76ee\u6a19\u3002\u4fe1\u9054\u751f\u7269\u6210\u7acb\u65bc<\/span>2011\u5e74\uff0c\u81f4\u529b\u65bc\u958b\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u7684\u5275\u65b0\u85e5\u7269\u30022018\u5e7410\u670831\u65e5\uff0c\u4fe1\u9054\u751f\u7269\u88fd\u85e5\u5728\u9999\u6e2f\u806f\u5408\u4ea4\u6613\u6240\u6709\u9650\u516c\u53f8\u4e3b\u677f\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a01801\u3002
<\/span><\/p>\n

\u81ea\u6210\u7acb\u4ee5\u4f86\uff0c\u516c\u53f8\u6191\u501f\u5275\u65b0\u6210\u679c\u548c\u570b\u969b\u5316\u7684\u904b\u71df\u6a21\u5f0f\u5728\u773e\u591a\u751f\u7269\u88fd\u85e5\u516c\u53f8\u4e2d\u812b\u7a4e\u800c\u51fa\u3002\u5efa\u7acb\u8d77\u4e86\u4e00\u689d\u5305\u62ec35\u500b\u65b0\u85e5\u54c1\u7a2e\u7684\u7522\u54c1\u93c8\uff0c\u8986\u84cb\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u3001\u773c\u79d1\u7b49\u591a\u500b\u75be\u75c5\u9818\u57df\uff0c\u5176\u4e2d7\u500b\u54c1\u7a2e\u5165\u9078\u570b\u5bb6\u300c\u91cd\u5927\u65b0\u85e5\u5275\u88fd\u300d\u5c08\u9805\u3002\u516c\u53f8\u5df2\u6709 8\u500b\u7522\u54c1\u7372\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c\u5b83\u5011\u5206\u5225\u662f\u4fe1\u8fea\u5229\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u4f2f\u8212<\/span>\u00ae<\/span>\uff09\uff0c\u8c9d\u4f10\u73e0\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u6538\u540c<\/span>\u00ae<\/span>\uff09\uff0c\u963f\u9054\u6728\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u8607\u7acb\u4fe1<\/span>\u00ae<\/span>\uff09\uff0c\u5229\u59a5\u6614\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u4f2f\u83ef\u00ae<\/span>\uff09<\/span>\uff0c\u4f69\u7c73\u66ff\u5c3c\u7247\uff08\u9054\u4f2f\u5766<\/span>\u00ae<\/span>\uff09\uff0c\u5967\u96f7\u5df4\u66ff\u5c3c\u7247\uff08\u8010\u7acb\u514b<\/span>\u00ae<\/span>\uff09\uff0c \u96f7\u83ab\u897f\u5c24\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u5e0c\u5189\u64c7<\/span>\u00ae<\/span>\uff09\uff0c\u585e\u666e\u66ff\u5c3c\u81a0\u56ca\uff08\u777f\u59a5\u00ae<\/span>\uff09<\/span>\uff0c<\/span>3\u500b\u54c1\u7a2e\u5728NMPA\u5be9\u8a55\u4e2d\uff0c6\u500b\u65b0\u85e5\u5206\u5b50\u9032\u5165III\u671f\u6216\u95dc\u9375\u6027\u81e8\u5e8a\u7814\u7a76\uff0c\u53e6\u5916\u9084\u670918\u500b\u65b0\u85e5\u54c1\u7a2e\u5df2\u9032\u5165\u81e8\u5e8a\u7814\u7a76\u3002
<\/span><\/p>\n

\u4fe1\u9054\u751f\u7269\u5df2\u7d44\u5efa\u4e86\u4e00\u652f\u5177\u6709\u570b\u969b\u5148\u9032\u6c34\u5e73\u7684\u9ad8\u7aef\u751f\u7269\u85e5\u958b\u767c\u3001\u7522\u696d\u5316\u4eba\u624d\u5718\u968a\uff0c\u5305\u62ec\u773e\u591a\u6d77\u6b78\u5c08\u5bb6\uff0c\u4e26\u8207\u79ae\u4f86\u3001\u7f85\u6c0f\u3001\u8cfd\u8afe\u83f2\u3001Adimab\u3001Incyte\u548cMD Anderson \u764c\u75c7\u4e2d\u5fc3\u7b49\u570b\u969b\u5408\u4f5c\u65b9\u9054\u621028\u9805\u6230\u7565\u5408\u4f5c\u3002<\/span><\/p>\n

\u4fe1\u9054\u751f\u7269\u5728\u4e0d\u65b7\u81ea\u7814\u5275\u65b0\u85e5\u7269\u3001\u8b00\u6c42\u81ea\u8eab\u767c\u5c55\u7684\u540c\u6642\uff0c\u79c9\u627f\u7d93\u6fdf\u5efa\u8a2d\u4ee5\u4eba\u6c11\u70ba\u4e2d\u5fc3\u7684\u767c\u5c55\u601d\u60f3\u3002\u591a\u5e74\u4f86\uff0c\u59cb\u7d42\u5fc3\u61f7\u79d1\u5b78\u5584\u5ff5\uff0c\u5805\u5b88\u300c\u4ee5\u60a3\u8005\u70ba\u4e2d\u5fc3\u300d\uff0c\u5fc3\u7e6b\u60a3\u8005\u4e26\u95dc\u6ce8\u60a3\u8005\u5bb6\u5ead\uff0c\u7a4d\u6975\u5c65\u884c\u793e\u6703\u8cac\u4efb\u3002\u516c\u53f8\u9678\u7e8c\u767c\u8d77\u3001\u53c3\u8207\u4e86\u591a\u9805\u85e5\u54c1\u516c\u76ca\u63f4\u52a9\u9805\u76ee\uff0c\u8b93\u8d8a\u4f86\u8d8a\u591a\u7684\u60a3\u8005\u80fd\u5920\u5f97\u76ca\u65bc\u751f\u547d\u79d1\u5b78\u7684\u9032\u6b65\uff0c\u7528\u5f97\u4e0a\u3001\u7528\u5f97\u8d77\u9ad8\u8cea\u91cf\u7684\u751f\u7269\u85e5\u3002\u81f3<\/span>2023\u5e743\u6708\uff0c\u4fe1\u9054\u751f\u7269\u60a3\u8005\u63f4\u52a9\u9805\u76ee\u5df2\u60e0\u53ca16\u4f59\u842c\u666e\u901a\u60a3\u8005\uff0c\u85e5\u7269\u6350\u8d08\u7e3d\u50f9\u503c\u6578\u5104\u5143\u3002<\/span><\/p>\n

\u4fe1\u9054\u751f\u7269\u5e0c\u671b\u548c\u5927\u5bb6\u4e00\u8d77\u52aa\u529b\uff0c\u63d0\u9ad8\u4e2d\u570b\u751f\u7269\u88fd\u85e5\u7522\u696d\u7684\u767c\u5c55\u6c34\u5e73\uff0c\u4ee5\u6eff\u8db3\u767e\u59d3\u7528\u85e5\u53ef\u53ca\u6027\u548c\u4eba\u6c11\u5c0d\u751f\u547d\u5065\u5eb7\u7f8e\u597d\u9858\u671b\u7684\u8ffd\u6c42\u3002<\/span><\/p>\n

\u8a73\u60c5\u8acb\u8a2a\u554f\u516c\u53f8\u7db2\u7ad9\uff1a<\/span>www.innoventbio.com\u6216\u516c\u53f8\u9818\u82f1\u8cec\u865f<\/span>www.linkedin.com\/company\/innovent-biologics\/<\/span><\/a>\u3002<\/span><\/p>\n

\u8072\u660e\uff1a<\/span>\u4fe1\u9054\u4e0d\u63a8\u85a6\u4efb\u4f55\u672a\u7372\u6279\u7684\u85e5\u54c1<\/span>\/\u9069\u61c9\u75c7\u4f7f\u7528\u3002<\/span><\/p>\n

\u524d\u77bb\u6027\u8072\u660e<\/span><\/p>\n

\u672c\u65b0\u805e\u7a3f\u6240\u767c\u4f48\u7684\u4fe1\u606f\u4e2d\u53ef\u80fd\u6703\u5305\u542b\u67d0\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u3002\u9019\u4e9b\u8868\u8ff0\u672c\u8cea\u4e0a\u5177\u6709\u76f8\u7576\u98a8\u96aa\u548c\u4e0d\u78ba\u5b9a\u6027\u3002\u5728\u4f7f\u7528\u300c\u9810\u671f\u300d\u3001\u300c\u76f8\u4fe1\u300d\u3001\u300c\u9810\u6e2c\u300d\u3001\u300c\u671f\u671b\u300d\u3001\u300c\u6253\u7b97\u300d\u53ca\u5176\u4ed6\u985e\u4f3c\u8a5e\u8a9e\u9032\u884c\u8868\u8ff0\u6642\uff0c\u51e1\u8207\u672c\u516c\u53f8\u6709\u95dc\u7684\uff0c\u5747\u5c6c\u65bc\u524d\u77bb\u6027\u8868\u8ff0\u3002\u672c\u516c\u53f8\u4e26\u7121\u7fa9\u52d9\u4e0d\u65b7\u5730\u66f4\u65b0\u9019\u4e9b\u9810\u6e2c\u6027\u9673\u8ff0\u3002<\/span><\/p>\n

\u9019\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u662f\u57fa\u65bc\u672c\u516c\u53f8\u7ba1\u7406\u5c64\u5728\u505a\u51fa\u8868\u8ff0\u6642\u5c0d\u672a\u4f86\u4e8b\u52d9\u7684\u73fe\u6709\u770b\u6cd5\u3001\u5047\u8a2d\u3001\u671f\u671b\u3001\u4f30\u8a08\u3001\u9810\u6e2c\u548c\u7406\u89e3\u3002\u9019\u4e9b\u8868\u8ff0\u4e26\u975e\u5c0d\u672a\u4f86\u767c\u5c55\u7684\u4fdd\u8b49\uff0c\u6703\u53d7\u5230\u98a8\u96aa\u3001\u4e0d\u78ba\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u97ff\uff0c\u6709\u4e9b\u662f\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u7bc4\u570d\uff0c\u96e3\u4ee5\u9810\u8a08\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u5011\u7684\u696d\u52d9\u3001\u7af6\u722d\u74b0\u5883\u3001\u653f\u6cbb\u3001\u7d93\u6fdf\u3001\u6cd5\u5f8b\u548c\u793e\u6703\u60c5\u6cc1\u7684\u672a\u4f86\u8b8a\u5316\u53ca\u767c\u5c55\u7684\u5f71\u97ff\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u6703\u8207\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8cc7\u6599\u6709\u8f03\u5927\u5dee\u5225\u3002<\/span>\u00a0<\/span><\/p>\n

\u672c\u516c\u53f8\u3001\u672c\u516c\u53f8\u8463\u4e8b\u53ca\u50f1\u54e1\u4ee3\u7406\u6982\u4e0d\u627f\u64d4<\/span> (a) \u66f4\u6b63\u6216\u66f4\u65b0\u672c\u7db2\u7ad9\u6240\u8f09\u524d\u77bb\u6027\u8868\u8ff0\u7684\u4efb\u4f55\u7fa9\u52d9;\u53ca (b) \u82e5\u56e0\u4efb\u4f55\u524d\u77bb\u6027\u8868\u8ff0\u4e0d\u80fd\u5be6\u73fe\u6216\u8b8a\u6210\u4e0d\u6b63\u78ba\u800c\u5f15\u81f4\u7684\u4efb\u4f55\u8cac\u4efb\u3002<\/span><\/p>\n

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[1] Qiu H, Zhou Z, Zhou Y, et al. Antitumor activity of olverembatinib (HQP1351) in patients (pts) with tyrosine kinase inhibitor (TKI)\u2013resistant succinate dehydrogenase (SDH)\u2013deficient gastrointestinal stromal tumor (GIST). J Clin Oncol 41, 2023 (suppl 16; abstr 11540)
<\/span>[2] Mantese G. Gastrointestinal stromal tumor: epidemiology, diagnosis, and treatment. Curr Opin Gastroenterol. 2019; 35(6): 555-559.
<\/span>[3] Call JW, Wang Y, Rothschild S, et al. Treatment responses in SDH-deficient GIST. LRG Science, https:\/\/liferaftgroup.org\/2019\/08\/treatmentresponses-in-sdh-deficient-gist-2\/<\/a>(2019, accessed 4 May 2022<\/span>).
<\/span>[4] Nannini M, Rizzo A, Indio V, et al. Targeted therapy in SDH-deficient GIST. Ther Adv Med Oncol. 2021; 13: 17588359211023278.
<\/span>[5] Weldon CB, Madenci AL, Boikos SA, et al. Surgical Management of Wild-Type Gastrointestinal Stromal Tumors: A Report From the National Institutes of Health Pediatric and Wildtype GIST Clinic. J Clin Oncol. 2017; 35(5): 523-528.
<\/span>[6] Mullassery D, Weldon CB. Pediatric\/”Wildtype” gastrointestinal stromal tumors. Semin Pediatr Surg. 2016; 25(5): 305-310.<\/span><\/p>\n

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