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BGB-11417\u662f\u4e00\u7a2e\u5f37\u6548\u3001\u9ad8\u9078\u64c7\u6027\u7684BCL-2\u6291\u5236\u5291\u3002\u5291\u91cf\u63a2\u7d22\u7814\u7a76\u7d50\u679c\u8868\u660e\u8a72\u8a66\u9a57\u6027\u5206\u5b50\u4f5c\u70ba\u55ae\u85e5\u6cbb\u7642B\u7d30\u80de\u60e1\u6027\u816b\u7624\u60a3\u8005\u4e2d\uff0c\u5728\u6700\u9ad8\u6bcf\u65e5640 mg\u7684\u6240\u6709\u8a66\u9a57\u5291\u91cf\u4e0b\u8010\u53d7\u6027\u5747\u826f\u597d\uff0c\u4e14\u672a\u51fa\u73fe\u5291\u91cf\u4f9d\u8cf4\u6027\u7684\u6bd2\u6027\u589e\u52a0\u3002BGB-11417\u55ae\u85e5\u6cbb\u7642\u5728R\/R\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\u4e2d\u4e5f\u986f\u793a\u51fa\u826f\u597d\u7684\u521d\u6b65\u7642\u6548\u7d50\u679c\uff0c\u60a3\u8005\u80fd\u5920\u5728\u8f03\u4f4e\u5291\u91cf\u6c34\u6e96\u4e0b\u7522\u751f\u7de9\u89e3\u3002<\/p>\n

\u9019\u4e00\u8a66\u9a57\u7d50\u679c\u5c07\u65bc\u5317\u4eac\u6642\u95936\u67085\u65e521:00\u81f36\u67086\u65e500:00\u4ee5\u6d77\u5831\u5f62\u5f0f\u9032\u884c\u5c55\u793a\uff08\u6458\u8981\u7de8\u865f#7558\uff09\u3002 <\/p>\n

\u95dc\u65bc\u767e\u6fdf\u795e\u5dde\u6458\u8981\u7684\u66f4\u591a\u8a73\u7d30\u4fe1\u606f\u898bASCO\u7db2\u7ad9<\/a>\u3002<\/p>\n

\u95dc\u65bc\u767e\u6085\u6fa4\u00ae\uff08\u6fa4\u5e03\u66ff\u5c3c\uff09<\/p>\n

\u767e\u6085\u6fa4\u00ae\u662f\u4e00\u6b3e\u7531\u767e\u6fdf\u795e\u5dde\u79d1\u5b78\u5bb6\u81ea\u4e3b\u7814\u767c\u7684\u5e03\u9b6f\u9813\u6c0f\u916a\u6c28\u9178\u6fc0\u9176\uff08BTK\uff09\u5c0f\u5206\u5b50\u6291\u5236\u5291\uff0c\u76ee\u524d\u6b63\u5728\u5168\u7403\u9032\u884c\u5ee3\u6cdb\u7684\u81e8\u5e8a\u8a66\u9a57\u9805\u76ee\uff0c\u4f5c\u70ba\u55ae\u85e5\u548c\u8207\u5176\u4ed6\u7642\u6cd5\u9032\u884c\u806f\u5408\u7528\u85e5\u6cbb\u7642\u591a\u7a2eB\u7d30\u80de\u60e1\u6027\u816b\u7624\u3002\u7531\u65bc\u65b0\u7684BTK\u6703\u5728\u4eba\u9ad4\u5167\u4e0d\u65b7\u5408\u6210\uff0c\u767e\u6085\u6fa4\u00ae\u7684\u8a2d\u8a08\u901a\u904e\u512a\u5316\u751f\u7269\u5229\u7528\u5ea6\u3001\u534a\u8870\u671f\u548c\u9078\u64c7\u6027\uff0c\u5be6\u73fe\u5c0dBTK\u86cb\u767d\u5b8c\u5168\u3001\u6301\u7e8c\u7684\u6291\u5236\u3002\u6191\u85c9\u8207\u5176\u4ed6\u7372\u6279BTK\u6291\u5236\u5291\u5b58\u5728\u5dee\u7570\u5316\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\u7279\u5fb5\uff0c\u767e\u6085\u6fa4\u00ae\u5df2\u88ab\u8b49\u660e\u80fd\u5728\u591a\u500b\u75be\u75c5\u76f8\u95dc\u7d44\u7e54\u4e2d\u6291\u5236\u60e1\u6027B\u7d30\u80de\u589e\u6b96\u3002<\/p>\n

\u767e\u6085\u6fa4\u00ae\u5df2\u958b\u5c55\u4e86\u5ee3\u6cdb\u7684\u5168\u7403\u81e8\u5e8a\u958b\u767c\u9805\u76ee\uff0c\u76ee\u524d\u5df2\u5728\u5168\u7403\u8d85\u904e29\u500b\u570b\u5bb6\u548c\u5730\u5340\u958b\u5c55\u4e8635\u9805\u8a66\u9a57\uff0c\u7e3d\u5165\u7d44\u53d7\u8a66\u8005\u8d85\u904e4,900\u4eba\u3002\u8fc4\u4eca\u70ba\u6b62\uff0c\u767e\u6085\u6fa4\u00ae\u5df2\u5728\u7f8e\u570b\u3001\u4e2d\u570b\u3001\u6b50\u76df\u3001\u82f1\u570b\u3001\u52a0\u62ff\u5927\u3001\u6fb3\u5927\u5229\u4e9e\u3001\u97d3\u570b\u3001\u745e\u58eb\u7b49\u8d85\u904e65\u500b\u5e02\u5834\u7372\u6279\u591a\u9805\u9069\u61c9\u75c7\u3002\u00a0<\/p>\n

\u95dc\u65bc\u767e\u6fa4\u5b89\u00ae\uff08\u66ff\u96f7\u5229\u73e0\u55ae\u6297\uff09<\/p>\n

\u767e\u6fa4\u5b89\u00ae\u662f\u4e00\u7a2e\u4eba\u6e90\u5316IgG4\u6297\u7a0b\u5f0f\u6027\u7d30\u80de\u6b7b\u4ea1\u86cb\u767d-1\uff08PD-1\uff09\u55ae\u514b\u9686\u6297\u9ad4\uff0c\u8a2d\u8a08\u76ee\u7684\u65e8\u5728\u6700\u5927\u9650\u5ea6\u5730\u6e1b\u5c11\u8207\u5de8\u566c\u7d30\u80de\u4e2dFc\u03b3\u53d7\u9ad4\u7d50\u5408\uff0c\u5e6b\u52a9\u4eba\u9ad4\u514d\u75ab\u7d30\u80de\u8b58\u5225\u4e26\u6bba\u50b7\u816b\u7624\u7d30\u80de\u3002\u81e8\u5e8a\u524d\u6578\u64da\u8868\u660e\uff0c\u5de8\u566c\u7d30\u80de\u4e2d\u7684Fc\u03b3\u53d7\u9ad4\u7d50\u5408\u4e4b\u5f8c\u6703\u555f\u52d5\u6297\u9ad4\u4f9d\u8cf4\u7d30\u80de\u4ecb\u5c0e\u6bba\u50b7T\u7d30\u80de\uff0c\u5f9e\u800c\u964d\u4f4e\u4e86PD-1\u6297\u9ad4\u7684\u6297\u816b\u7624\u6d3b\u6027\u3002<\/p>\n

\u767e\u6fa4\u5b89\u00ae\u5168\u7403\u81e8\u5e8a\u958b\u767c\u9805\u76ee\u5df2\u5728\u8d85\u904e30\u500b\u570b\u5bb6\u548c\u5730\u5340\u958b\u5c55\u8d85\u904e20\u9805\u8a3b\u518a\u76f8\u95dc\u7684\u8a66\u9a57\uff0c\u5165\u7d44\u8d85\u904e12,000\u4f8b\u60a3\u8005\u3002<\/p>\n

\u767e\u6fa4\u5b89\u00ae\u5df2\u670911\u9805\u9069\u61c9\u75c7\u7372\u5f97\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u6279\u51c6\u3002\u8fd1\u65e5\uff0c\u767e\u6fa4\u5b89\u00ae\u7372\u5f97NMPA\u6279\u51c6\uff0c\u806f\u5408\u5316\u7642\u7528\u65bc\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u3001\u5fa9\u767c\u6216\u8f49\u79fb\u6027\u98df\u7ba1\u9c57\u72c0\u7d30\u80de\u764c\u7684\u4e00\u7dda\u6cbb\u7642\u3002<\/p>\n

\u95dc\u65bcBGB-11417<\/p>\n

BGB-11417\u662f\u4e00\u7a2e\u5f37\u6548\u3001\u9ad8\u9078\u64c7\u6027BCL-2\u6291\u5236\u5291\uff0c\u80fd\u5920\u7522\u751f\u66f4\u6df1\u5165\u3001\u6301\u4e45\u7684\u9776\u9ede\u6291\u5236\u3002<\/p>\n

\u8207\u7dad\u5948\u514b\u62c9\u76f8\u6bd4\uff0cBGB-11417\u5728\u81e8\u5e8a\u524d\u7814\u7a76\u548c\u816b\u7624\u6a21\u578b\u4e2d\u8868\u73fe\u51fa\u66f4\u9ad8\u7684\u6548\u50f9\u5f37\u5ea6\uff08>10\u500d\uff09\u548c\u9776\u9ede\u9078\u64c7\u6027\uff0c\u4e26\u5c55\u73fe\u51fa\u514b\u670d\u6cbb\u7642\u8010\u85e5\u6027\u7684\u8de1\u8c61\u3002[i]<\/p>\n

\u95dc\u65bcBGB-A445<\/p>\n

BGB-A445\u662f\u4e00\u7a2e\u76f4\u63a5\u4f5c\u7528\u65bcOX40\u6297\u539f\u7684\u5728\u7814\u6fc0\u52d5\u6027\u6297\u9ad4\u3002BGB-A445\u662f\u4e00\u7a2e\u975e\u914d\u9ad4\u7af6\u722d\u6027\u6297\u9ad4\uff0c\u4e0d\u6703\u7834\u58deOX40\u8207OX40\u914d\u9ad4\u7684\u7d50\u5408\u3002\u81e8\u5e8a\u524d\u5be6\u9a57\u8868\u660e\uff0cBGB-A445\u5728\u8f03\u9ad8\u5291\u91cf\u4e0b\u7684\u6709\u6548\u6027\u589e\u52a0\uff0c\u800c\u914d\u9ad4\u7af6\u722d\u6027\u6297\u9ad4\u5728\u8f03\u9ad8\u5291\u91cf\u4e0b\u6703\u51fa\u73fe\u6709\u6548\u6027\u4e0b\u964d\u3002<\/p>\n

\u95dc\u65bc\u767e\u6fdf\u795e\u5dde<\/p>\n

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\u524d\u77bb\u6027\u8072\u660e<\/p>\n

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[i] Nan Hu<\/span>, Yunhang Guo, Hai Xue<\/span>, Ye Liu, Yin Guo<\/span>, Fan Wang<\/span>, Xiaomin Song<\/span>, Ying Guo<\/span>, Shuaishuai Chen, Haipeng Xu<\/span>, Taichang Zhang<\/span>, Yanwen Ma<\/span>, Xuebing Sun<\/span>, Yuan Hong, Yutong Zhu<\/span>, Aiying Xu<\/span>, Zhenzhen Cheng<\/span>, Haimei Xing, Zhiwei Wang<\/span>, Xuesong Liu<\/span>, Lai Wang<\/span>; Abstract 3077: Preclinical characterization of BGB-11417, a potent and selective Bcl-2 inhibitor with superior antitumor activities in haematological tumor models. Cancer Res\u00a015 August 2020; 80 (16_Supplement): 3077.\u00a0https:\/\/doi.org\/10.1158\/1538-7445.AM2020-3077<\/a><\/p>","protected":false},"excerpt":{"rendered":"

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