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 <\/p>\n<p>\u6de8\u8667\u640d\uff1a\u622a\u81f32023\u5e743\u670831\u65e5\u7684\u7b2c\u4e00\u5b63\u5ea6\u5167\uff0c\u6de8\u8667\u640d\u70ba3.484\u5104\u7f8e\u5143\uff0c\u5373\u6bcf\u80a1\u8667\u640d0.26\u7f8e\u5143\uff0c\u6bcf\u80a1\u7f8e\u570b\u5b58\u6258\u80a1\u4efd\uff08ADS\uff09\u8667\u640d3.34\u7f8e\u5143\uff1b\u76f8\u6bd4\u8f03\uff0c2022\u5e74\u540c\u671f\u6de8\u8667\u640d\u70ba4.352\u5104\u7f8e\u5143\uff0c\u5373\u6bcf\u80a1\u8667\u640d0.33\u7f8e\u5143\uff0c\u6bcf\u80a1ADS\u8667\u640d4.25\u7f8e\u5143\u3002\u6de8\u8667\u640d\u6e1b\u5c11\u4e3b\u8981\u56e0\u70ba\u7522\u54c1\u6536\u5165\u589e\u9577\u8d85\u904e\u4e86\u7d93\u71df\u8cbb\u7528\u589e\u9577\uff0c\u5f9e\u800c\u63d0\u9ad8\u4e86\u7d93\u71df\u6760\u6746\u3002\u516c\u53f8\u9810\u8a08\u57282023\u5e74\u5c07\u7e7c\u7e8c\u4fdd\u6301\u9019\u4e00\u8da8\u52e2\u3002<\/p>\n<p>\u73fe\u91d1\u3001\u73fe\u91d1\u7b49\u50f9\u7269\u3001\u53d7\u9650\u8cc7\u91d1\u548c\u77ed\u671f\u6295\u8cc7\uff1a\u622a\u81f32023\u5e743\u670831\u65e5\u70ba38\u5104\u7f8e\u5143\uff1b\u76f8\u6bd4\u8f03\uff0c\u622a\u81f32022\u5e7412\u670831\u65e5\uff0c\u8a72\u90e8\u5206\u8cc7\u91d1\u70ba45\u5104\u7f8e\u5143\u3002\u00a0<\/p>\n<p>\u622a\u81f32023\u5e743\u670831\u65e5\u7684\u4e09\u500b\u6708\u5167\uff0c\u7d93\u71df\u6d3b\u52d5\u73fe\u91d1\u652f\u51fa\u70ba5.638\u5104\u7f8e\u5143\uff0c\u4e3b\u8981\u7531\u65bc\u6de8\u8667\u640d3.484\u5104\u7f8e\u5143\uff0c\u4ee5\u53ca\u7531\u65bc\u5b63\u7bc0\u6027\u652f\u4ed8\u7684\u61c9\u6536\u8cec\u6b3e\u548c\u85aa\u916c\u76f8\u95dc\u4ed8\u6b3e\uff0c\u71df\u904b\u8cc7\u672c\u589e\u52a02.941\u5104\u7f8e\u5143\u3002\u9019\u4e9b\u88ab\u6de8\u8667\u640d\u4e2d\u7684\u975e\u73fe\u91d1\u652f\u51fa7,870\u842c\u7f8e\u5143\u6240\u90e8\u5206\u62b5\u6d88\u3002\u8cc7\u672c\u652f\u51fa\u70ba1.256\u5104\u7f8e\u5143\uff0c\u7528\u65bc\u878d\u8cc7\u6d3b\u52d5\u7684\u73fe\u91d1\u70ba1,990\u842c\u7f8e\u5143\u3002<\/p>\n<p>\u622a\u81f32022\u5e743\u670831\u65e5\u7684\u4e09\u500b\u6708\u5167\uff0c\u7d93\u71df\u6d3b\u52d5\u73fe\u91d1\u652f\u51fa\u70ba2.366\u5104\u7f8e\u5143\uff0c\u4e3b\u8981\u7531\u65bc\u6de8\u8667\u640d4.352\u5104\u7f8e\u5143\uff0c\u4f46\u88ab\u6de8\u8667\u640d\u4e2d\u7684\u975e\u73fe\u91d1\u652f\u51fa8,090\u842c\u7f8e\u5143\u90e8\u5206\u62b5\u6d88\u3002\u7531\u65bc\u4f86\u81ea\u8afe\u83ef\u5c31\u6b50\u53f8\u73c0\u5229\u55ae\u6297\u5408\u4f5c\u76843\u5104\u7f8e\u5143\u9996\u4ed8\u6b3e\uff0c\u7d93\u71df\u6027\u8cc7\u7522\u548c\u8ca0\u50b5\u6de8\u984d\u6e1b\u5c111.177\u5104\u7f8e\u5143\uff0c\u90e8\u5206\u88ab\u85aa\u916c\u76f8\u95dc\u652f\u4ed8\u9020\u6210\u7684\u5b63\u7bc0\u6027\u71df\u904b\u8cc7\u672c\u62b5\u6d88\uff1b\u8cc7\u672c\u652f\u51fa\u70ba4,510\u842c\u7f8e\u5143\uff1b\u7528\u65bc\u878d\u8cc7\u6d3b\u52d5\u7684\u73fe\u91d1\u70ba1,130\u842c\u7f8e\u5143\u3002  <\/p>\n<p>\u8fd1\u671f\u696d\u52d9\u4eae\u9ede<\/p>\n<p>\u5546\u696d\u904b\u71df<\/p>\n<p>2023\u5e74\u7b2c\u4e00\u5b63\u5ea6\uff0c\u516c\u53f8\u7522\u54c1\u92b7\u552e\u984d\u540c\u6bd4\u589e\u957757%\uff0c\u4e3b\u8981\u5f97\u76ca\u4e8e\u81ea\u4e3b\u7814\u767c\u7522\u54c1\u767e\u6085\u6fa4\u00ae\u3001\u767e\u6fa4\u5b89\u00ae\uff0c\u4ee5\u53ca\u5b89\u9032\u548c\u767e\u5967\u6cf0\u6388\u6b0a\u7522\u54c1\u7684\u92b7\u552e\u984d\u589e\u9577\u3002<\/p>\n<p>   2023\u5e74\u7b2c\u4e00\u5b63\u5ea6\uff0c\u767e\u6085\u6fa4\u00ae\u5168\u7403\u92b7\u552e\u984d\u70ba2.114\u5104\u7f8e\u5143\uff0c\u76f8\u8f03\u53bb\u5e74\u540c\u671f\u589e\u9577103%\u3002\u5728\u7f8e\u570b\uff0c\u5f97\u76ca\u65bcCLL\/SLL\u9069\u61c9\u75c7\u4e0a\u5e02\u7684\u63a8\u52d5\uff0c\u767e\u6085\u6fa4\u00ae2023\u5e74\u7b2c\u4e00\u5b63\u5ea6\u7684\u92b7\u552e\u984d\u9054\u52301.388\u5104\u7f8e\u5143\uff0c\u76f8\u8f03\u53bb\u5e74\u540c\u671f\u589e\u9577104%\u3002\u96a8\u8457\u81e8\u5e8a\u91ab\u751f\u7684\u4f7f\u7528\u589e\u591a\u4ee5\u53ca\u8655\u65b9\u6578\u91cf\u7684\u6301\u7e8c\u589e\u9577\uff0c\u767e\u6085\u6fa4\u00ae\u5728\u6240\u6709\u5df2\u7372FDA\u6279\u51c6\u7684\u9069\u61c9\u75c7\u4e2d\u7684\u61c9\u7528\u5feb\u901f\u589e\u52a0\u3002\u5728\u4e2d\u570b\uff0c\u767e\u6085\u6fa4\u00ae2023\u5e74\u7b2c\u4e00\u5b63\u5ea6\u7684\u92b7\u552e\u984d\u70ba4,810\u842c\u7f8e\u5143\uff0c\u76f8\u8f03\u53bb\u5e74\u540c\u671f\u589e\u957744%\uff0c\u4e3b\u8981\u5f97\u76ca\u65bc\u5728\u6240\u6709\u5df2\u7372\u6279\u9069\u61c9\u75c7\u9818\u57df\u7684\u92b7\u552e\u984d\u589e\u9577\u3002<\/p>\n<p>   2023\u5e74\u7b2c\u4e00\u5b63\u5ea6\uff0c\u767e\u6fa4\u5b89\u00ae\u5728\u4e2d\u570b\u7684\u92b7\u552e\u984d\u70ba1.149\u5104\u7f8e\u5143\uff0c\u76f8\u8f03\u53bb\u5e74\u540c\u671f\u589e\u957731%\u3002\u767e\u6fa4\u5b89\u00ae\u5e02\u5834\u6ef2\u900f\u7387\u548c\u5e02\u5834\u4efd\u984d\u7684\u63d0\u5347\uff0c\u4e3b\u8981\u5f97\u76ca\u65bc\u91ab\u4fdd\u5831\u92b7\u7bc4\u570d\u64f4\u5927\u6240\u5e36\u4f86\u7684\u65b0\u589e\u60a3\u8005\u9700\u6c42\u3001\u92b7\u552e\u5718\u968a\u6548\u7387\u7684\u9032\u4e00\u6b65\u63d0\u5347\u4ee5\u53ca\u85e5\u54c1\u9032\u9662\u6578\u91cf\u7684\u589e\u52a0\u3002  <\/p>\n<p>\u85e5\u653f\u9032\u5c55\u548c\u7814\u767c\u9805\u76ee<\/p>\n<p>\u767e\u6085\u6fa4\u00ae\uff08\u6fa4\u5e03\u66ff\u5c3c\uff09\uff1a\u4e00\u6b3e\u65e8\u5728\u6700\u5927\u5316\u5e03\u9b6f\u9813\u6c0f\u916a\u6c28\u9178\u6fc0\u9176\uff08BTK\uff09\u4f54\u6709\u7387\u3001\u6700\u5c0f\u5316\u812b\u9776\u6548\u61c9\u7684\u5c0f\u5206\u5b50BTK\u6291\u5236\u5291\uff0c\u5df2\u5728\u7f8e\u570b\u3001\u4e2d\u570b\u3001\u6b50\u76df\u3001\u82f1\u570b\u3001\u52a0\u62ff\u5927\u3001\u6fb3\u5927\u5229\u4e9e\u3001\u97d3\u570b\u3001\u745e\u58eb\u7b49\u8d85\u904e65\u500b\u5e02\u5834\u7372\u6279\u591a\u9805\u9069\u61c9\u75c7\uff0c\u76ee\u524d\u6b63\u5728\u9032\u4e00\u6b65\u81e8\u5e8a\u958b\u767c\uff0c\u4ee5\u5728\u5168\u7403\u7bc4\u570d\u5167\u53d6\u5f97\u66f4\u591a\u4e0a\u5e02\u6279\u51c6\u3002\u767e\u6085\u6fa4\u00ae\u5168\u7403\u958b\u767c\u9805\u76ee\u5df2\u572829\u500b\u570b\u5bb6\u548c\u5730\u5340\u5165\u7d44\u8d85\u904e4,900\u4f8b\u53d7\u8a66\u8005\u3002<\/p>\n<p>\u57fa\u65bc3\u671fALPINE\u8a66\u9a57\u4e2d\u767e\u6085\u6fa4\u00ae\u5728R\/R CLL\u6210\u4eba\u60a3\u8005\u4e2d\u53d6\u5f97\u7121\u9032\u5c55\u751f\u5b58\u671f\u7684\u6700\u7d42\u5206\u6790\u7d50\u679c\uff0c\u5411\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u905e\u4ea4\u65b0\u9069\u61c9\u75c7\u88dc\u5145\u8aaa\u660e\u3002<\/p>\n<p>   \u5728\u6fb3\u5927\u5229\u4e9e\u7372\u6279\u7528\u65bc\u6cbb\u7642CLL\/SLL\u6210\u4eba\u60a3\u8005\u3002<\/p>\n<p>   \u6b50\u76df\u5df2\u53d7\u7406\u767e\u6085\u6fa4\u00ae\u7528\u65bc\u6cbb\u7642R\/R\u6ffe\u6ce1\u6027\u6dcb\u5df4\u7624\uff08FL\uff09\u7684\u65b0\u9069\u61c9\u75c7\u4e0a\u5e02\u7533\u8acb\uff08sNDA\uff09\uff0c\u4ee5\u53ca\u57fa\u65bc\u5728R\/R CLL\u60a3\u8005\u4e2d\u53d6\u5f97PFS\u512a\u6548\u6027\u7d50\u679c\u7684\u65b0\u9069\u61c9\u75c7\u88dc\u5145\u8aaa\u660e\u3002<\/p>\n<p>   \u5728ACCESS\u806f\u76df\uff08ACCESS consortium\uff09\u4e0b\u7684\u745e\u58eb\u3001\u82f1\u570b\u548c\u52a0\u62ff\u5927\u905e\u4ea4\u767e\u6085\u6fa4\u00ae\u7528\u65bc\u6cbb\u7642R\/R FL\u7684sNDA\u3002<\/p>\n<p>   \u62d3\u5c55\u767e\u6085\u6fa4\u00ae\u7684\u5168\u7403\u85e5\u653f\u8a3b\u518a\u9805\u76ee\uff0c2023\u5e74\u6709\u671b\u5728\u8d85\u904e30\u500b\u5e02\u5834\u53d6\u5f97\u85e5\u653f\u6279\u51c6\u3002  <\/p>\n<p>\u767e\u6fa4\u5b89\u00ae\uff08\u66ff\u96f7\u5229\u73e0\u55ae\u6297\uff09\uff1a\u4e00\u6b3e\u4eba\u6e90\u5316IgG4\u6297PD-1\u55ae\u514b\u9686\u6297\u9ad4\uff0c\u5176\u7d50\u69cb\u7d93\u7279\u6b8a\u6539\u9020\uff0c\u53ef\u6700\u5927\u9650\u5ea6\u6e1b\u5c11\u8207\u5de8\u566c\u7d30\u80de\u4e0a\u7684Fc\u03b3\u53d7\u9ad4\u7d50\u5408\u3002\u767e\u6fa4\u5b89\u00ae\u5df2\u5728\u4e2d\u570b\u7372\u6279\u7528\u65bc10\u9805\u9069\u61c9\u75c7\uff0c\u76ee\u524d\u6b63\u5728\u9032\u4e00\u6b65\u958b\u767c\uff0c\u4ee5\u5728\u5168\u7403\u7bc4\u570d\u5167\u7372\u5f97\u66f4\u591a\u4e0a\u5e02\u6279\u51c6\u3002\u767e\u6fa4\u5b89\u00ae\u5168\u7403\u81e8\u5e8a\u958b\u767c\u9805\u76ee\u5df2\u572831\u500b\u570b\u5bb6\u548c\u5730\u5340\u5165\u7d44\u8d85\u904e12,100\u4f8b\u53d7\u8a66\u8005\u3002<\/p>\n<p>\u57282023\u5e74\u7f8e\u570b\u764c\u75c7\u7814\u7a76\u5354\u6703\uff08AACR\uff09\u5e74\u6703\u4e0a\uff0c\u516c\u4f48\u4e86RATIONALE-302\uff08NCT03430843\uff09\u3001RATIONALE-304\uff08NCT03663205\uff09\u3001RATIONALE-306\uff08NCT03783442\uff09\u548cRATIONALE-307\uff08NCT03594747\uff09\u7814\u7a76\u7684\u7d50\u679c\u3002<\/p>\n<p>   \u5ba3\u4f48\u767e\u6fa4\u5b89\u00ae\u6cbb\u7642\u665a\u671f\u80c3\u6216\u80c3\u98df\u7ba1\u7d50\u5408\u90e8\u817a\u764c\u76843\u671f\u8a66\u9a57\u53d6\u5f97\u7a4d\u6975\u7d50\u679c\u3002<\/p>\n<p>   \u7f8e\u570bFDA\u5c07\u65bc\u4eca\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u5c0d\u767e\u6fa4\u5b89\u00ae\u65b0\u85e5\u4e0a\u5e02\u8a31\u53ef\u7533\u8acb\uff08BLA\uff09\u9032\u884c\u7372\u6279\u524d\u7684\u751f\u7522\u57fa\u5730\u73fe\u5834\u6838\u67e5\u3002  <\/p>\n<p>\u6b50\u53f8\u73c0\u5229\u55ae\u6297\uff08BGB-A1217\uff09\uff1a\u4e00\u6b3e\u5177\u6709\u5b8c\u5584Fc\u529f\u80fd\u7684\u5728\u7814\u6297TIGIT\u55ae\u514b\u9686\u6297\u9ad4\u3002\u6b50\u53f8\u73c0\u5229\u55ae\u6297\u7684\u5168\u7403\u81e8\u5e8a\u958b\u767c\u9805\u76ee\u5df2\u572820\u500b\u570b\u5bb6\u548c\u5730\u5340\u5165\u7d44\u8d85\u904e1,700\u4f8b\u53d7\u8a66\u8005\u3002<\/p>\n<p>\u806f\u5408\u767e\u6fa4\u5b89\u00ae\u548c\u5316\u7642\u3001\u7528\u65bc\u4e00\u7dda\u6cbb\u7642\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u76842\u671f\u8a66\u9a57\uff08NCT05014815\uff09\u5df2\u5b8c\u6210\u60a3\u8005\u5165\u7d44\u5de5\u4f5c\u3002  <\/p>\n<p>BGB-11417\uff1a\u4e00\u6b3e\u9ad8\u9078\u64c7\u6027\u3001\u5f37\u6548\u7684\u5728\u7814BCL-2\u6291\u5236\u5291\uff0c\u76ee\u524d\u6b63\u5728\u9032\u884c\u81e8\u5e8a\u958b\u767c\uff0c\u4f5c\u70ba\u55ae\u85e5\u6216\u8207\u767e\u6085\u6fa4\u00ae\/\u5967\u59a5\u73e0\u55ae\u6297\u806f\u5408\u7528\u85e5\u6cbb\u7642B\u7d30\u80de\u60e1\u6027\u816b\u7624\u3001\u8207\u963f\u7d2e\u80de\u82f7\u806f\u5408\u7528\u85e5\u6cbb\u7642\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u548c\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\uff08MDS\uff09\uff0c\u4ee5\u53ca\u4f5c\u70ba\u55ae\u85e5\u6216\u8207\u5730\u585e\u7c73\u677e\/\u5361\u975e\u4f50\u7c73\u806f\u5408\u6cbb\u7642\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08MM\uff09\u3002BGB-11417\u7684\u5168\u7403\u81e8\u5e8a\u958b\u767c\u9805\u76ee\u5df2\u57287\u500b\u570b\u5bb6\u548c\u5730\u5340\u5165\u7d44\u8d85\u904e430\u4f8b\u53d7\u8a66\u8005\u3002<\/p>\n<p>\u7e7c\u7e8c\u63a8\u52d5BGB-11417\u7528\u65bc\u6cbb\u7642R\/R \u5957\u7d30\u80de\u6dcb\u5df4\u7624\uff08MCL\uff09\uff08NCT05471843\uff09\u548cR\/R CLL\/SLL\uff08NCT05479994\uff09\u7684\u6f5b\u5728\u8a3b\u518a\u53ef\u75282\u671f\u7814\u7a76\u7684\u81e8\u5e8a\u958b\u767c\u3002  <\/p>\n<p>BGB-A445\uff1a\u4e00\u6b3e\u975e\u914d\u9ad4\u7af6\u722d\u6027\u5728\u7814\u6297OX40\u55ae\u514b\u9686\u6297\u9ad4\uff0c\u6b63\u4f5c\u70ba\u55ae\u85e5\u6216\u8207\u767e\u6fa4\u5b89\u00ae\u806f\u5408\u7528\u85e5\u9032\u884c\u81e8\u5e8a\u958b\u767c\u3002<\/p>\n<p>\u806f\u5408\u767e\u6fa4\u5b89\u00ae\u3001\u7528\u65bc\u6cbb\u7642\u5be6\u9ad4\u7624\u76841\u671f\u5291\u91cf\u905e\u589e\u8a66\u9a57\uff08NCT04215978\uff09\u5df2\u5b8c\u6210\u60a3\u8005\u5165\u7d44\u5de5\u4f5c\u3002  <\/p>\n<p>\u65e9\u671f\u81ea\u4e3b\u7814\u767c\u9805\u76ee<\/p>\n<p>\u7e7c\u7e8c\u63a8\u9032\u65e9\u671f\u81e8\u5e8a\u7ba1\u7dda\u4e2d\u81ea\u4e3b\u7814\u767c\u5019\u9078\u85e5\u7269\u7684\u5291\u91cf\u905e\u589e\u968e\u6bb5\u7814\u7a76\uff0c\u5305\u62ec\uff1a  <\/p>\n<p class=\"prnml40\">\u2013\u00a0 BGB-B167\uff1a\u4e00\u6b3e\u5728\u7814\u3001\u6f5b\u5728\u300c\u540c\u985e\u9996\u5275\u300dCEA x 4-1BB\u96d9\u7279\u7570\u6027\u6297\u9ad4\u85e5\u7269\uff0c\u4f5c\u70ba\u55ae\u85e5\u6216\u806f\u5408\u767e\u6fa4\u5b89\u00ae\u6cbb\u7642\u9078\u64c7\u6027\u8868\u9054CEA\u7684\u665a\u671f\u6216\u8f49\u79fb\u6027\u5be6\u9ad4\u7624\u60a3\u8005\uff0c\u5305\u62ec\u7d50\u76f4\u8178\u764c\uff08CRC\uff09\uff1b<\/p>\n<p class=\"prnml40\">\u2013\u00a0 BGB-A425\uff1a\u4e00\u6b3e\u806f\u5408\u767e\u6fa4\u5b89\u00ae\u6cbb\u7642\u982d\u9838\u90e8\u9c57\u72c0\u7d30\u80de\u764c\u3001NSCLC\u548c\u814e\u7d30\u80de\u764c\u7684\u5728\u7814\u6297TIM-3\u6297\u9ad4\uff1b<\/p>\n<p class=\"prnml40\">\u2013\u00a0 BGB-15025\uff1a\u4e00\u6b3e\u4f5c\u70ba\u55ae\u85e5\u6216\u806f\u5408\u767e\u6fa4\u5b89\u00ae\u6cbb\u7642\u5be6\u9ad4\u7624\u7684\u5728\u7814\u3001\u6f5b\u5728\u300c\u540c\u985e\u9996\u5275\u300d\u7684\u9020\u8840\u5e79\u7d30\u80de\u6fc0\u91761\uff08HPK1\uff09\u6291\u5236\u5291\uff1b<\/p>\n<p class=\"prnml40\">\u2013\u00a0 BGB-16673\uff1a\u4e00\u6b3e\u5728\u7814\u5d4c\u5408\u5f0f\u964d\u89e3\u555f\u52d5\u5316\u5408\u7269\uff08CDAC\uff09\uff0c\u9776\u5411BTK\u86cb\u767d\u964d\u89e3\uff0c\u4f5c\u70ba\u55ae\u85e5\u6cbb\u7642B\u7d30\u80de\u60e1\u6027\u816b\u7624\uff1b<\/p>\n<p class=\"prnml40\">\u2013\u00a0 BGB-24714\uff1a\u4e00\u6b3e\u5728\u7814\u7684\u7b2c\u4e8c\u7dda\u7c92\u9ad4\u4f86\u6e90\u534a\u80f1\u6c28\u9178\u86cb\u767d\u9176\u555f\u52d5\u5291\uff08SMAC\uff09\u6a21\u64ec\u7269\uff0c\u4f5c\u70ba\u55ae\u85e5\u6216\u806f\u5408\u7d2b\u6749\u9187\u7528\u65bc\u6cbb\u7642\u665a\u671f\u5be6\u9ad4\u7624\uff0c\u5176\u81e8\u5e8a\u524d\u7814\u7a76\u7d50\u679c\u5df2\u57282023\u5e74AACR\u5e74\u6703\u4e0a\u516c\u4f48\uff1b<\/p>\n<p class=\"prnml40\">\u2013\u00a0 BGB-10188\uff1a\u4e00\u6b3e\u4f5c\u70ba\u55ae\u85e5\u6216\u806f\u5408\u767e\u6085\u6fa4\u00ae\u6cbb\u7642\u8840\u6db2\u60e1\u6027\u816b\u7624\uff0c\u6216\u806f\u5408\u767e\u6fa4\u5b89\u00ae\u6cbb\u7642\u5be6\u9ad4\u7624\u7684\u5728\u7814PI3K\u03b4\u6291\u5236\u5291\uff1b<\/p>\n<p class=\"prnml40\">\u2013\u00a0 BGB-23339\uff1a\u4e00\u6b3e\u5728\u7814\u5f37\u6548\u916a\u6c28\u9178\u6fc0\u91762\uff08TYK2\uff09\u8b8a\u69cb\u6291\u5236\u5291\u3002<\/p>\n<p>\u5408\u4f5c\u9805\u76ee<\/p>\n<p>\u8207SpringWorks Therapeutics\u5408\u4f5c\uff0c\u5728AACR\u5e74\u6703\u4e0a\u516c\u4f48\u5728\u7814B-RAF\u6291\u5236\u5291lifirafenib\uff08BGB-283\uff09\u8207SpringWorks\u7684MEK\u6291\u5236\u5291mirdametinib\u806f\u5408\u7528\u65bc\u651c\u5e36RAS\u7a81\u8b8a\u3001RAF\u7a81\u8b8a\u548c\u5176\u4ed6MAPK\u901a\u8def\u7570\u5e38\u7684\u665a\u671f\u6216\u96e3\u6cbb\u6027\u5be6\u9ad4\u7624\u60a3\u8005\u76841b\u671f\u81e8\u5e8a\u6578\u64da\u3002<\/p>\n<p>   \u8207MapKure\u548cSpringWorks\u5408\u4f5c\uff0c\u5728AACR\u5e74\u6703\u4e0a\u516c\u4f48\u5728\u7814\u9ad8\u9078\u64c7\u6027RAF\u4e8c\u805a\u9ad4\u6291\u5236\u5291brimarafenib \uff08BGB-3245\uff09\u7528\u65bc\u6cbb\u7642\u651c\u5e36MAPK\u901a\u8def\u7570\u5e38\u7684\u665a\u671f\u6216\u96e3\u6cbb\u6027\u5be6\u9ad4\u7624\u6210\u4eba\u60a3\u8005\u76841a\/b\u671f\u81e8\u5e8a\u6578\u64da\u3002<\/p>\n<p>   \u8207\u5357\u4eac\u7dad\u7acb\u5fd7\u535a\u5408\u4f5c\uff0c\u5728\u9776\u5411LAG-3\u901a\u8def\u7684\u65b0\u578b\u5728\u7814\u6297\u9ad4LBL-007\u806f\u5408\u767e\u6fa4\u5b89\u00ae\u548c\u8c9d\u4f10\u73e0\u55ae\u6297\u52a0\u5361\u57f9\u4ed6\u6ff1\uff0c\u6cbb\u7642\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027CRC\u76842\u671f\u81e8\u5e8a\u8a66\u9a57\uff08NCT05609370\uff09\u4e2d\u555f\u52d5\u60a3\u8005\u5165\u7d44\u5de5\u4f5c\u3002<\/p>\n<p>   \u6b64\u5916\uff0c\u9084\u8207\u5357\u4eac\u7dad\u7acb\u5fd7\u535a\u5408\u4f5c\uff0c\u5728LBL-007\u8207\u767e\u6fa4\u5b89\u00ae\u806f\u5408\u7528\u85e5\uff0c\u5c0d\u6bd4\u767e\u6fa4\u5b89\u00ae\u8207\u5176\u4ed6\u85e5\u7269\u806f\u5408\u7528\u85e5\uff08\u5305\u62ecBGB-A445\u548c\u6b50\u53f8\u73c0\u5229\u55ae\u6297\uff09\u7684\u5098\u5f0f\u7814\u7a76\uff08NCT05635708\u3001NCT05577702\uff09\u4e2d\u555f\u52d5\u60a3\u8005\u7d66\u85e5\u3002  <\/p>\n<p>\u751f\u7522\u904b\u71df<\/p>\n<p>\u4f4d\u65bc\u7f8e\u570b\u65b0\u6fa4\u897f\u5dde\u970d\u666e\u97cb\u723e\u666e\u6797\u65af\u9813\u897f\u90e8\u5275\u65b0\u5712\u5340\u7684\u5728\u5efa\u65d7\u8266\u7d1a\u751f\u7522\u57fa\u5730\u548c\u81e8\u5e8a\u7814\u767c\u4e2d\u5fc3\u5df2\u5b8c\u6210\u92fc\u6a11\u540a\u88dd\u5c01\u9802\u3002\u8a72\u57fa\u5730\u9810\u7559\u4e86\u8d85\u904e100\u842c\u5e73\u65b9\u82f1\u5c3a\uff08\u7d049.3\u842c\u5e73\u65b9\u7c73\uff09\u7684\u53ef\u958b\u767c\u5730\u7522\uff0c\u4ee5\u5099\u7528\u4e8e\u672a\u4f86\u7684\u9032\u4e00\u6b65\u62d3\u5c55\u3002<\/p>\n<p>   \u6301\u7e8c\u5efa\u8a2d\u4f4d\u65bc\u4e2d\u570b\u5ee3\u5dde\u7684\u4e16\u754c\u4e00\u6d41\u751f\u7269\u85e5\u751f\u7522\u57fa\u5730\uff0c\u76ee\u524d\u7e3d\u7522\u80fd\u5df2\u9054\u523054,000\u5347\uff0c\u9810\u8a082023\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u7522\u80fd\u9084\u5c07\u984d\u5916\u589e\u52a010,000\u5347\u3002<\/p>\n<p>   \u5728\u5ee3\u5dde\u555f\u52d5\u6297\u9ad4\u5076\u806f\u85e5\u7269\uff08ADC\uff09\u751f\u7522\u8a2d\u65bd\u53ca\u5168\u65b0\u751f\u7269\u85e5\u751f\u7522\u5927\u6a13\u7684\u5efa\u8a2d\uff0c\u9810\u8a08\u5c07\u65bc2024\u5e74\u5b8c\u5de5\uff1b\u5728\u8607\u5dde\u555f\u52d5\u65b0\u7814\u767c\u4e2d\u5fc3\u7684\u5efa\u8a2d\uff0c\u4ee5\u63d0\u9ad8\u81e8\u5e8a\u548c\u5546\u696d\u5316\u751f\u7522\u80fd\u529b\uff0c\u8a72\u9805\u76ee\u9810\u8a08\u5c07\u65bc2025\u5e74\u5b8c\u5de5\u3002<\/p>\n<p>   \u7e7c\u7e8c\u5efa\u8a2d\u4f4d\u65bc\u4e2d\u570b\u8607\u5dde\u7684\u65b0\u5efa\u5c0f\u5206\u5b50\u5275\u65b0\u85e5\u7269\u7522\u696d\u5316\u57fa\u5730\u3002\u7b2c\u4e00\u968e\u6bb5\u7684\u5efa\u8a2d\u9762\u7a4d\u9810\u8a08\u5c07\u8d85\u904e55.9\u842c\u5e73\u65b9\u82f1\u5c3a\uff08\u7d045.2\u842c\u5e73\u65b9\u7c73\uff09\uff0c\u56fa\u9ad4\u5236\u5291\u7522\u80fd\u53ef\u64f4\u5927\u81f36\u5104\u7247\uff08\u7c92\uff09\u5291\u6b21\uff0c\u8a72\u9805\u76ee\u9810\u8a08\u5c07\u65bc2023\u5e74\u5167\u5b8c\u5de5\u3002\u5f85\u57fa\u5730\u5efa\u8a2d\u5b8c\u6210\u3001\u9a57\u6536\u5408\u683c\u4e26\u7372\u6279\u5f8c\uff0c\u9810\u8a08\u6211\u5011\u5728\u4e2d\u570b\u7684\u5c0f\u5206\u5b50\u85e5\u7269\u751f\u7522\u80fd\u529b\u6700\u9ad8\u5c07\u63d0\u5347\u81f3\u76ee\u524d\u768410\u500d\u3002  <\/p>\n<p>\u4f01\u696d\u767c\u5c55<\/p>\n<p>\u5ba3\u4f48\u5df4\u897f\u8056\u4fdd\u7f85\u8fa6\u4e8b\u8655\u6b63\u5f0f\u555f\u7528\uff0c\u6a19\u8a8c\u8457\u516c\u53f8\u5728\u62c9\u4e01\u7f8e\u6d32\u7684\u767c\u5c55\u898f\u5283\u5df2\u9081\u51fa\u91cd\u8981\u4e00\u6b65\u3002  <\/p>\n<p>\u9810\u8a08\u91cc\u7a0b\u7891\u4e8b\u4ef6\u00a0<\/p>\n<p>\u767e\u6085\u6fa4\u00ae\uff08\u6fa4\u5e03\u66ff\u5c3c\uff09<\/p>\n<p>\u7e7c\u7e8c\u652f\u6301\u7f8e\u570bFDA\u548c\u6b50\u6d32\u85e5\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u5c0dR\/R CLL\u7684\u65b0\u9069\u61c9\u75c7\u88dc\u5145\u8aaa\u660e\u7684\u5be9\u8a55\u5de5\u4f5c\uff0c\u8a72\u7533\u8acb\u57fa\u65bc\u767e\u6085\u6fa4\u00ae\u5c0d\u6bd4\u5104\u73c2\u00ae\u5728R\/R CLL\u4e2d\u6240\u53d6\u5f97\u7684PFS\u512a\u6548\u6027\u7d50\u679c\u3002<\/p>\n<p>   \u7e7c\u7e8c\u652f\u6301\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u5c0d\u4e00\u7ddaCLL\/SLL\u548cWM\u7684sNDA\u7684\u5be9\u8a55\u5de5\u4f5c\uff0c\u9810\u8a08\u5176\u5c07\u65bc2023\u5e74\u4e0a\u534a\u5e74\uff0c\u5c0d\u8a72\u5be9\u8a55\u505a\u51fa\u6c7a\u8b70\u3002<\/p>\n<p>   \u7e7c\u7e8c\u652f\u6301\u52a0\u62ff\u5927\u885b\u751f\u90e8\u5c0dCLL\u7684sNDA\u7684\u5be9\u8a55\u5de5\u4f5c\uff0c\u9810\u8a08\u5176\u5c07\u65bc2023\u5e74\u5c07\u5c0d\u8a72\u5be9\u8a55\u505a\u51fa\u6c7a\u8b70\u3002<\/p>\n<p>   \u7e7c\u7e8c\u5728\u5168\u7403\u66f4\u591a\u7684\u65b0\u5730\u5340\u548c\u65b0\u7684\u9069\u61c9\u75c7\u4e2d\u62d3\u5c55\u767e\u6085\u6fa4\u00ae\u5168\u7403\u85e5\u653f\u8a3b\u518a\u9805\u76ee\u3002<\/p>\n<p>   \u5c07\u65bc2023\u5e74ASCO\u5e74\u6703\u4e0a\uff0c\u5c55\u793a\u767e\u6085\u6fa4\u00ae\u806f\u5408\u4f86\u90a3\u5ea6\u80fa\u6cbb\u7642R\/R\u5f4c\u6f2b\u6027\u5927B\u7d30\u80de\u6dcb\u5df4\u7624\u76841\u671f\u7814\u7a76\u7684\u9996\u6b21\u671f\u4e2d\u5206\u6790\u7d50\u679c\uff0c\u4ee5\u53ca\u767e\u6085\u6fa4\u00ae\u806f\u5408\u5967\u59a5\u73e0\u55ae\u6297\u5c0d\u6bd4\u5967\u59a5\u73e0\u55ae\u6297\u6cbb\u7642\u5fa9\u767c\u6216\u96e3\u6cbb\u6027\u6ffe\u6ce1\u6027\u6dcb\u5df4\u7624\u7684ROSEWOOD\u7814\u7a76\u7684\u6700\u65b0\u5206\u6790\u6458\u8981\u3002  <\/p>\n<p>\u767e\u6fa4\u5b89\u00ae\uff08\u66ff\u96f7\u5229\u73e0\u55ae\u6297\uff09<\/p>\n<p>\u7e7c\u7e8c\u652f\u6301NMPA\u5c0d\u767e\u6fa4\u5b89\u00ae\u65b0\u9069\u61c9\u75c7\u4e0a\u5e02\u7533\u8acb\uff08BLA\uff09\u7684\u5be9\u8a55\u5de5\u4f5c\uff0c\u5305\u62ec\u806f\u5408\u5316\u7642\u7528\u65bc\u4e00\u7dda\u6cbb\u7642\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u3001\u5fa9\u767c\/\u8f49\u79fb\u6027ESCC\u60a3\u8005\uff08\u9810\u8a08\u5176\u5c07\u65bc2023\u5e74\u4e0a\u534a\u5e74\u505a\u51fa\u5be9\u8a55\u6c7a\u8b70\uff09\uff0c\u4ee5\u53ca\u7528\u65bc\u4e00\u7dda\u6cbb\u7642\u809d\u7d30\u80de\u764c\u60a3\u8005\uff08\u9810\u8a08\u5176\u5c07\u65bc2023\u5e74\u4e0b\u534a\u5e74\u505a\u51fa\u5be9\u8a55\u6c7a\u8b70\uff09\u3002   \u7e7c\u7e8c\u652f\u6301\u591a\u500b\u85e5\u76e3\u6a5f\u69cb\u5c0d\u65bc\u767e\u6fdf\u795e\u5dde\u905e\u4ea4\u7684\u767e\u6fa4\u5b89\u00ae\u4e0a\u5e02\u7533\u8acb\u7684\u5be9\u8a55\u5de5\u4f5c\uff0c\u5305\u62ec\uff1a  <\/p>\n<p class=\"prnml40\">\u2013\u00a0 \u6fb3\u5927\u5229\u4e9e\u85e5\u54c1\u7ba1\u7406\u5c40\uff08TGA\uff09\u5c0d\u767e\u6fa4\u5b89\u00ae\u7528\u65bc\u4e00\u7dda\u548c\u4e8c\u7dda\u6cbb\u7642NSCLC\u4ee5\u53ca\u4e8c\u7dda\u6cbb\u7642ESCC\u7684BLA\u5be9\u8a55\u5de5\u4f5c\uff0c\u9810\u8a08\u5c07\u65bc2023\u5e74\u4e0b\u534a\u5e74\u5c0d\u8a72\u5be9\u8a55\u505a\u51fa\u6c7a\u8b70\uff1b\u4ee5\u53ca\u7d10\u897f\u862d\u85e5\u54c1\u548c\u91ab\u7642\u5668\u68b0\u5b89\u5168\u7ba1\u7406\u5c40\uff08Medsafe\uff09\u5c0d\u767e\u6fa4\u5b89\u00ae\u7528\u65bc\u4e00\u7dda\u548c\u4e8c\u7dda\u6cbb\u7642NSCLC\u4ee5\u53ca\u4e8c\u7dda\u6cbb\u7642ESCC\u7684BLA\u7684\u5be9\u8a55\u5de5\u4f5c\uff1b<\/p>\n<p class=\"prnml40\">\u2013\u00a0 \u97d3\u570b\u98df\u54c1\u85e5\u54c1\u5b89\u5168\u90e8\uff08MFDS\uff09\u5c0d\u767e\u6fa4\u5b89\u00ae\u7528\u65bc\u4e8c\u7dda\u6cbb\u7642ESCC\u7684BLA\u7684\u5be9\u8a55\u5de5\u4f5c\uff1b<\/p>\n<p class=\"prnml40\">\u2013\u00a0 \u5df4\u897f\u570b\u5bb6\u885b\u751f\u76e3\u7763\u5c40\uff08Anvisa\uff09\u5c0d\u767e\u6fa4\u5b89\u00ae\u7528\u65bc\u4e00\u7dda\u548c\u4e8c\u7dda\u6cbb\u7642NSCLC\u548c\u4e8c\u7dda\u6cbb\u7642ESCC\u7684BLA\u7684\u5be9\u8a55\u5de5\u4f5c\u3002<\/p>\n<p>\u8207\u8afe\u83ef\u5408\u4f5c\uff0c\u7e7c\u7e8c\u652f\u6301\u5c0d\u767e\u6fa4\u5b89\u00ae\u7684\u4e0a\u5e02\u7533\u8acb\u5be9\u8a55\u5de5\u4f5c\uff0c\u5305\u62ec\uff1a\u00a0  <\/p>\n<p class=\"prnml40\">\u2013\u00a0 \u7f8e\u570bFDA\u6b63\u5728\u5be9\u8a55\u7684\u767e\u6fa4\u5b89\u00ae\u7528\u65bc\u4e8c\u7dda\u6cbb\u7642ESCC\u7684BLA\uff0c\u9810\u8a08\u5c07\u65bc2023\u5e74\u505a\u51fa\u5be9\u8a55\u6c7a\u8b70\uff1b\u00a0<\/p>\n<p class=\"prnml40\">\u2013\u00a0 EMA\u5c0d\u767e\u6fa4\u5b89\u00ae\u7528\u65bc\u4e00\u7dda\u548c\u4e8c\u7dda\u6cbb\u7642NSCLC\uff0c\u4ee5\u53ca\u7528\u65bc\u4e8c\u7dda\u6cbb\u7642ESCC\u4e0a\u5e02\u7533\u8acb\u7684\u5be9\u8a55\u5de5\u4f5c\uff0c\u9810\u8a08\u5c07\u65bc2023\u5e74\u505a\u51fa\u5be9\u8a55\u6c7a\u8b70\uff1b<\/p>\n<p class=\"prnml40\">\u2013\u00a0 \u82f1\u570b\u85e5\u54c1\u8207\u5065\u5eb7\u7522\u54c1\u7ba1\u7406\u5c40\u5c0d\u767e\u6fa4\u5b89\u00ae\u7528\u65bc\u4e00\u7dda\u548c\u4e8c\u7dda\u6cbb\u7642NSCLC\u4ee5\u53ca\u4e8c\u7dda\u6cbb\u7642ESCC\u4e0a\u5e02\u7533\u8acb\u7684\u5be9\u8a55\u5de5\u4f5c\uff1b\u00a0<\/p>\n<p class=\"prnml40\">\u2013\u00a0 \u745e\u58eb\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u5c0d\u767e\u6fa4\u5b89\u00ae\u7528\u65bc\u4e8c\u7dda\u6cbb\u7642ESCC\u548c\u4e8c\u7dda\u6cbb\u7642NSCLC\u4e0a\u5e02\u7533\u8acb\u7684\u5be9\u8a55\u5de5\u4f5c\uff1b<\/p>\n<p class=\"prnml40\">\u2013\u00a0 \u652f\u6301\u8afe\u83ef\u8a08\u756b\u4e8e2023\u5e74\u5411\u7f8e\u570bFDA\u905e\u4ea4\u767e\u6fa4\u5b89\u00ae\u7528\u65bc\u4e00\u7dda\u6cbb\u7642\u80c3\u764c\u548c\u4e00\u7dda\u6cbb\u7642\u4e0d\u53ef\u5207\u9664ESCC\u7684\u8a3b\u518a\u7533\u5831\u5de5\u4f5c\uff1b<\/p>\n<p class=\"prnml40\">\u2013\u00a0 \u5c07\u65bc2023\u5e74\u5167\u5411\u65e5\u672c\u85e5\u54c1\u548c\u91ab\u7642\u5668\u68b0\u7ba1\u7406\u5c40\u905e\u4ea4\u767e\u6fa4\u5b89\u00ae\u7528\u65bc\u4e00\u7dda\u548c\u4e8c\u7dda\u6cbb\u7642ESCC\u7684BLA\u3002<\/p>\n<p>\u5c07\u65bc2023\u5e74\u516c\u4f48\u5ee3\u6cdb\u671f\u5c0f\u7d30\u80de\u80ba\u764c\u95dc\u9375\u6027\u8a66\u9a57\u7684\u6700\u7d42\u5206\u6790\u6578\u64da\u3002   \u5c07\u65bc2023\u5e74ASCO\u5e74\u6703\u4e0a\uff0c\u901a\u904e\u6d77\u5831\u5c55\u793aRATIONALE 301\u7814\u7a76\u88dc\u5145\u5206\u6790\u7684\u5169\u4efd\u6458\u8981\u3002  <\/p>\n<p>BGB-11417\uff08BCL-2\u6291\u5236\u5291\uff09<\/p>\n<p>\u5c07\u4e8e2023\u5e74\u4e0b\u534a\u5e74\u555f\u52d5\u806f\u5408\u767e\u6085\u6fa4\u00ae\u7528\u65bc\u4e00\u7dda\u6cbb\u7642CLL\u7684\u5168\u7403\u95dc\u9375\u6027\u8a66\u9a57\u3002<\/p>\n<p>   \u5c07\u5c0d\u6b63\u5728\u958b\u5c55\u7684\u7814\u7a76\u9032\u884c\u6578\u64da\u516c\u4f48\u3002<\/p>\n<p>   \u5c07\u65bc2023\u5e74ASCO\u5e74\u6703\u4e0a\uff0c\u901a\u904e\u6d77\u5831\u5c55\u793a\u4e00\u98051\u671f\u7814\u7a76\u6458\u8981\uff0c\u8a55\u4f30BGB-11417\u7528\u65bc\u6cbb\u7642\u6210\u719fB\u7d30\u80de\u60e1\u6027\u816b\u7624\u6210\u4eba\u60a3\u8005\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u85e5\u4ee3\u52d5\u529b\u5b78\u548c\u521d\u6b65\u6297\u816b\u7624\u6d3b\u6027\u3002  <\/p>\n<p>\u6b50\u53f8\u73c0\u5229\u55ae\u6297\uff08\u6297TIGIT\u6297\u9ad4\uff09<\/p>\n<p>\u5c07\u4e8e2023\u5e74\u516c\u4f48\u591a\u98052\u671f\u7814\u7a76\u6578\u64da\uff0c\u5305\u62ec\uff1a\u00a0  <\/p>\n<p class=\"prnml40\">\u2013\u00a0 \u7528\u65bc\u4e8c\u7dda\u6cbb\u7642\u816b\u7624\u8868\u9054PD-(L)1\u7684ESCC\uff08NCT04732494\uff09\uff1b<\/p>\n<p class=\"prnml40\">\u2013\u00a0 \u7528\u65bc\u4e00\u7dda\u6cbb\u7642\u809d\u7d30\u80de\u764c\uff08NCT04948697\uff09\uff1b<\/p>\n<p class=\"prnml40\">\u2013\u00a0 \u7528\u65bc\u4e00\u7dda\u6cbb\u7642NSCLC\uff08NCT05014815\uff09\u3002<\/p>\n<p>\u5c07\u65bc2023\u5e74\u5b8c\u6210\u7528\u65bc\u4e00\u7dda\u6cbb\u7642NSCLC\u76843\u671fAdvanTIG-302\u8a66\u9a57\u7684\u5165\u7d44\u5de5\u4f5c\u3002<\/p>\n<p>   \u5c07\u57282023\u5e74ASCO\u5e74\u6703\u4e0a\uff0c\u901a\u904e\u6d77\u5831\u5c55\u793a1b\u671fAdvanTIG-105\u7684\u7814\u7a76\u6458\u8981\u3002  <\/p>\n<p>BGB-16673\uff08BTK CDAC\uff09<\/p>\n<p>\u5c07\u65bc2023\u5e74\u516c\u4f48\u7528\u65bc\u6cbb\u7642B\u7d30\u80de\u60e1\u6027\u816b\u7624\u76841\u671f\u7814\u7a76\uff08NCT05006716\u3001NCT05294731\uff09\u521d\u6b65\u6578\u64da\u3002  <\/p>\n<p>BGB-A445\uff08\u6297OX40\u6297\u9ad4\uff09<\/p>\n<p>\u5c07\u65bc2023\u5e74\u516c\u4f48\u7528\u65bc\u6cbb\u7642\u5be6\u9ad4\u7624\u76841\u671f\u7814\u7a76\uff08NCT04215978\uff09\u521d\u6b65\u6578\u64da\u3002<\/p>\n<p>   \u5c07\u65bc2023\u5e74ASCO\u5e74\u6703\u4e0a\uff0c\u901a\u904e\u6d77\u5831\u5c55\u793aOX40\u6fc0\u52d5\u5291BGB-A445\u806f\u5408\u6216\u4e0d\u806f\u5408\u767e\u6fa4\u5b89\u00ae<span>\u6cbb\u7642\u665a\u671f\u5be6\u9ad4\u7624\u76841\u671f\u7814\u7a76\u6458\u8981\u3002<\/span><\/p>\n<p>BGB-15025\uff08HPK1\u6291\u5236\u5291\uff09<\/p>\n<p>\u5c07\u4e8e2023\u5e74\u555f\u52d5\u806f\u5408\u767e\u6fa4\u5b89\u00ae\u7528\u65bc\u6cbb\u7642\u5be6\u9ad4\u7624\u7684\u5291\u91cf\u64f4\u5c55\u7814\u7a76\uff08NCT04649385\uff09\u3002  <\/p>\n<p>\u5408\u4f5c\u9805\u76ee\u00a0<\/p>\n<p>\u5c07\u65bc2023\u5e74ASCO\u5e74\u6703\u4e0a\uff0c\u901a\u904e\u6d77\u5831\u5c55\u793a\u9776\u5411HER2\u7684\u96d9\u7279\u7570\u6027\u6297\u9ad4zanidatamab\u806f\u5408\u591a\u897f\u4ed6\u8cfd\uff0c\u7528\u65bc\u4e00\u7dda\u6cbb\u7642\u665a\u671fHER2\u967d\u6027\u4e73\u817a\u764c\u60a3\u8005\u76841b\/2\u671f\u7814\u7a76\u7684\u6700\u65b0\u7d50\u679c\u6458\u8981\uff0c\u4e26\u53e3\u982d\u5831\u544azanidatamab\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u7d93\u6cbb\u7684HER2\u57fa\u56e0\u64f4\u589e\u81bd\u9053\u764c\u7684\u95dc\u9375\u60272b\u671fHERIZON-BTC-01\u7814\u7a76\u6458\u8981\u3002  <\/p>\n<p>\u65b0\u51a0\u75ab\u60c5\u5f71\u97ff\u53ca\u61c9\u5c0d\u63aa\u65bd<\/p>\n<p>\u6211\u5011\u6b63\u5728\u6301\u7e8c\u76e3\u6e2c\u65b0\u51a0\u75ab\u60c5\u5c0d\u516c\u53f8\u696d\u52d9\u7684\u5f71\u97ff\u3002\u65b0\u51a0\u75ab\u60c5\u5c07\u53ef\u80fd\u7e7c\u7e8c\u5c0d\u6211\u5011\u7684\u696d\u52d9\u9020\u6210\u4e00\u5b9a\u7684\u8ca0\u9762\u5f71\u97ff\uff0c\u5305\u62ec\u5546\u696d\u92b7\u552e\u3001\u85e5\u653f\u6e9d\u901a\u3001\u6aa2\u67e5\u53ca\u7533\u5831\u3001\u751f\u7522\u3001\u81e8\u5e8a\u8a66\u9a57\u60a3\u8005\u5165\u7d44\u3001\u53c3\u8207\u53ca\u6578\u64da\u516c\u4f48\u3002\u6211\u5011\u6b63\u5728\u52aa\u529b\u6e1b\u5c11\u56e0\u75ab\u60c5\u6240\u5c0e\u81f4\u7684\u5de5\u4f5c\u5ef6\u9072\u548c\u4e2d\u65b7\uff0c\u4e26\u5df2\u5236\u5b9a\u76f8\u95dc\u5354\u5b9a\u548c\u6d41\u7a0b\uff0c\u78ba\u4fdd\u516c\u53f8\u7e7c\u7e8c\u6309\u7167\u5728\u5168\u7403\u7bc4\u570d\u5167\u5236\u5b9a\u7684\u5546\u696d\u5316\u3001\u85e5\u653f\u4e8b\u52d9\u3001\u751f\u7522\u53ca\u81e8\u5e8a\u958b\u767c\u76ee\u6a19\u958b\u5c55\u76f8\u95dc\u5de5\u4f5c\u3002<\/p>\n<p>\u8ca1\u52d9\u6458\u8981<\/p>\n<div>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u7c21\u660e\u5408\u4f75\u8cc7\u7522\u8ca0\u50b5\u8868\u6458\u8981\u6578\u64da\uff08\u7f8e\u570b\u516c\u8a8d\u6703\u8a08\u539f\u5247\uff09<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\uff08\u55ae\u4f4d\uff1a\u5343\u7f8e\u5143\uff09<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u622a\u81f3<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">2023\u5e74<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">2022\u5e74\u00a0<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">3\u670831\u65e5<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">12\u670831\u65e5<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\uff08\u672a\u7d93\u5be9\u8a08\uff09<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\uff08\u7d93\u5be9\u8a08\uff09<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u8cc7\u7522\uff1a<\/span><\/p>\n<p>     <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u73fe\u91d1\u3001\u73fe\u91d1\u7b49\u50f9\u7269\u3001\u53d7\u9650\u8cc7\u91d1\u548c\u77ed\u671f\u6295\u8cc7<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">$\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 3,837,823<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">$\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 4,540,288<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u61c9\u6536\u8cec\u6b3e\u6de8\u984d<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">309,628<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">173,168<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u5b58\u8ca8<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">296,995<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">282,346<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u56fa\u5b9a\u8cc7\u7522\u8207\u8a2d\u5099\u6de8\u984d<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">925,404<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">845,946<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u7e3d\u8cc7\u7522<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">5,956,775<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">6,379,290<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u8ca0\u50b5\u53ca\u6240\u6709\u8005\u6b0a\u76ca\uff1a<\/span><\/p>\n<p>     <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u61c9\u4ed8\u5e33\u6b3e<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">241,360<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">294,781<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u9810\u63d0\u8cbb\u7528\u53ca\u5176\u4ed6\u61c9\u4ed8\u6b3e\u9805<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">417,922<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">467,352<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u905e\u5ef6\u6536\u5165<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">222,822<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">255,887<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u7814\u767c\u6210\u672c\u5206\u6524\u8ca0\u50b5<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">276,562<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">293,960<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u501f\u6b3e<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">488,106<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">538,117<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u7e3d\u8ca0\u50b5<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">1,799,469<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">1,995,935<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u6240\u6709\u8005\u6b0a\u76ca\u5408\u8a08<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">$\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 4,157,306<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">$\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 4,383,355<\/span><\/p>\n<\/div>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n<div>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u7c21\u660e\u5408\u4f75\u640d\u76ca\u8868\uff08\u7f8e\u570b\u516c\u8a8d\u6703\u8a08\u539f\u5247\uff09<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\uff08\u9664\u666e\u901a\u80a1\u6578\u91cf\u3001ADS\u6578\u91cf\u3001\u6bcf\u80a1\u666e\u901a\u80a1\u548c\u6bcf\u80a1ADS\u6578\u64da\u5916\uff0c\u5176\u9918\u55ae\u4f4d\u5747\u70ba\u5343\u7f8e\u5143\uff09<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u622a\u81f33\u670831\u65e5\u524d\u76843\u500b\u6708<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">2023\u5e74<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">2022\u5e74[1]<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\uff08\u672a\u7d93\u5be9\u8a08\uff09<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u6536\u5165\uff1a<\/span><\/p>\n<p>     <\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u7522\u54c1\u6536\u5165\u6de8\u984d<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">$\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 410,291<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">$\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 261,573<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5408\u4f5c\u6536\u5165<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">37,510<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">45,053<\/span><\/p>\n<p class=\"prnml20\"><span class=\"prnews_span\">\u7e3d\u6536\u5165<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">447,801<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">306,626<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u8cbb\u7528\uff1a<\/span><\/p>\n<p>     <\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u7522\u54c1\u92b7\u552e\u6210\u672c<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">81,789<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">65,237<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u7814\u767c\u8cbb\u7528<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">408,584<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">389,915<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u92b7\u552e\u53ca\u7ba1\u7406\u8cbb\u7528<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">328,499<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">294,573<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u7121\u5f62\u8cc7\u7522\u6524\u92b7<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">187<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">188<\/span><\/p>\n<p class=\"prnml20\"><span class=\"prnews_span\">\u8cbb\u7528\u7e3d\u8a08<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">819,059<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">749,913<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u7d93\u71df\u8667\u640d<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(371,258)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(443,287)<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5229\u606f\u6536\u5165\uff08\u8cbb\u7528\uff09\uff0c\u6de8\u984d<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">16,016<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">10,071<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5176\u4ed6\uff08\u8667\u640d\uff09\u6536\u5165\uff0c\u6de8\u984d<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">18,303<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">11,967<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u6240\u5f97\u7a05\u524d\u8667\u640d<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(336,939)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(421,249)<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u6240\u5f97\u7a05\u8cbb\u7528<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">11,492<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">13,949<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u6de8\u8667\u640d<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(348,431)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(435,198)<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u6b78\u5c6c\u767e\u6fdf\u795e\u5dde\u7684\u6bcf\u80a1\u6de8\u8667\u640d\uff1a<\/span><\/p>\n<p>     <\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u57fa\u672c\u53ca\u7a00\u91cb<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">$\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 (0.26)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">$\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 (0.33)<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u6d41\u901a\u80a1\u52a0\u6b0a\u5e73\u5747\u6578\uff1a<\/span><\/p>\n<p>     <\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u57fa\u672c\u53ca\u7a00\u91cb<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">1,354,164,760<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">1,332,017,262<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u6b78\u5c6c\u767e\u6fdf\u795e\u5dde\u7684\u6bcf\u80a1<\/span><span class=\"prnews_span\">ADS<\/span><span class=\"prnews_span\">\u6de8\u8667\u640d\uff1a<\/span><\/p>\n<p>     <\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u57fa\u672c\u53ca\u7a00\u91cb<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">$\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 (3.34)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">$\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 (4.25)<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u6d41\u901a<\/span><span class=\"prnews_span\">ADS<\/span><span class=\"prnews_span\">\u52a0\u6b0a\u5e73\u5747\u6578\uff1a<\/span><\/p>\n<p>     <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u00a0 \u00a0 \u57fa\u672c\u53ca\u7a00\u91cb<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">104,166,520<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">102,462,866<\/span><\/p>\n<p>     <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">[1]\u6211\u5011\u4fee\u8a02\u4e86\u90e8\u5206\u4ee5\u524d\u671f\u9593\u8ca1\u52d9\u5831\u8868\u4ee5\u66f4\u6b63\u905e\u5ef6\u6240\u5f97\u7a05\u6de8\u8cc7\u7522\u4f30\u503c\u76f8\u95dc\u7684\u4e00\u9805\u5dee\u932f\uff0c\u8a72\u9805\u5dee\u932f\u5c0d\u5148\u524d\u5df2\u767c\u4f48\u76842022\u5e74<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u7b2c\u4e00\u5b63\u5ea6\u8ca1\u52d9\u5831\u8868\u4e0d\u91cd\u5927\uff08\u8acb\u53c3\u95b1\u5411\u7f8e\u570b\u8b49\u5238\u4ea4\u6613\u59d4\u54e1\u6703\u63d0\u4ea4\u7684\u622a\u81f32023\u5e743\u670831\u65e5\u6b6210-Q\u8868\u683c\u5b63\u5ea6\u5831\u544a\u4e2d\u7c21\u660e<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u5408\u4f75\u8ca1\u52d9\u5831\u8868\u7684\u76f8\u95dc\u9644\u6ce8\uff0c\u300c\u9644\u6ce81.\u696d\u52d9\u63cf\u8ff0\u3001\u5448\u5217\u57fa\u6e96\u53ca\u5408\u4f75\u539f\u5247\u548c\u91cd\u5927\u6703\u8a08\u653f\u7b56\u300d\u4ee5\u53ca\u300c\u9644\u6ce82.\u524d\u671f\u8ca1\u52d9\u5831\u8868\u4fee<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u8a02\u300d\uff09\u3002<\/span><\/p>\n<\/div>\n<p>\u95dc\u65bc\u767e\u6fdf\u795e\u5dde<\/p>\n<p>\u767e\u6fdf\u795e\u5dde\u662f\u4e00\u5bb6\u5168\u7403\u6027\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u5c08\u6ce8\u65bc\u70ba\u5168\u7403\u764c\u75c7\u60a3\u8005\u767c\u73fe\u548c\u958b\u767c\u5275\u65b0\u6297\u816b\u7624\u85e5\u7269\uff0c\u63d0\u9ad8\u85e5\u7269\u53ef\u53ca\u6027\u548c\u53ef\u8ca0\u64d4\u6027\u3002\u901a\u904e\u5f37\u5927\u7684\u81ea\u4e3b\u7814\u767c\u80fd\u529b\u548c\u5916\u90e8\u6230\u7565\u5408\u4f5c\uff0c\u6211\u5011\u4e0d\u65b7\u52a0\u901f\u958b\u767c\u591a\u5143\u3001\u5275\u65b0\u7684\u85e5\u7269\u7ba1\u7dda\u3002\u6211\u5011\u81f4\u529b\u65bc\u70ba\u5168\u7403\u66f4\u591a\u60a3\u8005\u5168\u9762\u6539\u5584\u85e5\u7269\u53ef\u53ca\u6027\u3002\u767e\u6fdf\u795e\u5dde\u5728\u5168\u7403\u4e94\u5927\u6d32\u6253\u9020\u4e86\u4e00\u652f\u8d85\u904e9,400\u4eba\u7684\u5718\u968a\uff0c\u4e26\u5728\u4e2d\u570b\u5317\u4eac\u3001\u7f8e\u570b\u9ebb\u7701\u528d\u6a4b\u548c\u745e\u58eb\u5df4\u585e\u723e\u8a2d\u7acb\u4e86\u4e3b\u8981\u8fa6\u4e8b\u8655\u3002\u6b32\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f<span><a href=\"http:\/\/www.beigene.com.cn\/\" target=\"_blank\" rel=\"noopener\">http:\/\/www.beigene.com.cn<\/a><\/span>\u3002<\/p>\n<p>\u524d\u77bb\u6027\u8072\u660e<\/p>\n<p>\u672c\u65b0\u805e\u7a3f\u5305\u542b\u6839\u64da\u300a1995\u5e74\u79c1\u4eba\u8b49\u5238\u8a34\u8a1f\u6539\u9769\u6cd5\u6848\u300b\uff08Private Securities Litigation Reform Act of 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