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\u7531\u7dad\u4e9e\u751f\u7269\u53c3\u8207\u6295\u8cc7\u5b75\u5316\u7684Basking Biosciences\uff08\u4ee5\u4e0b\u7c21\u7a31\u300cBasking\u300d\uff09\u662f\u4e00\u5bb6\u958b\u767c\u5168\u7403\u9996\u6b3e\u53ef\u9006\u6027\u7f3a\u8840\u6027\u8166\u5352\u4e2d\u6eb6\u6813\u7642\u6cd5\u7684\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u57282023\u570b\u969b\u8166\u5352\u4e2d\u5927\u6703(ISC)\u4e0a\u516c\u5e03\u4e86\u5176\u65b0\u578b\u8840\u7ba1\u6027\u8840\u53cb\u75c5\u56e0\u5b50(vWF)\u9776\u5411\u6eb6\u6813\u5291BB-031\u5728\u5065\u5eb7\u5fd7\u9858\u8005\u4e2d\u9032\u884c1\u671f\u55ae\u6b21\u905e\u589e\u5291\u91cf\u5b89\u5168\u6027\u7814\u7a76\u7684\u7a4d\u6975\u7d50\u679c\u3002BB-031\u5728\u55ae\u6b21\u975c\u8109\u6ce8\u5c04\uff08\u5291\u91cf\u7bc4\u570d\u72320.1mg\/kg-4.0mg\/kg\uff09\u4ee5\u53cavWF\u7d50\u5408\u548c\u8840\u5c0f\u677f\u529f\u80fd\u8b8a\u5316\u7684\u5291\u91cf\u4f9d\u8cf4\u6027\u6a21\u5f0f\u5f8c\uff0c\u986f\u793a\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002<\/p>\n<p>\u57281\u671f\u7814\u7a76\u4e2d\uff0c\u5065\u5eb7\u5fd7\u9858\u8005\u901a\u904e\u975c\u8109\u63a8\u6ce8\u63a5\u53d7BB-031\u6216\u5b89\u6170\u5291\uff08\u6bd4\u4f8b\u72326\uff1a2\uff09\u6cbb\u7642\uff0c\u55ae\u6b21\u905e\u589e\u5291\u91cf\u7bc4\u570d\u72320.1mg\/kg\u81f34.0mg\/kg\u3002\u7814\u7a76\u767c\u73fe\uff0cBB-031\u5728\u6574\u500b28\u5929\u7684\u7814\u7a76\u671f\u9593\uff0c\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u826f\u597d\uff0c\u6c92\u6709\u986f\u8457\u4e0d\u826f\u4e8b\u4ef6\u3002BB-031\u986f\u793a\u51fa\u660e\u986f\u7684\u5e73\u5747\u7d42\u672b\u534a\u8870\u671f\uff0c\u7bc4\u570d\u5f9e18\u5206\u9418(0.1mg\/kg)\u523061\u5206\u9418(4.0mg\/kg)\uff0c\u89c0\u5bdf\u5230vWF\u7d50\u5408\u7684\u5291\u91cf\u4f9d\u8cf4\u6027\u8b8a\u5316\u3002\u8840\u5c0f\u677f\u529f\u80fd\u5206\u6790\u986f\u793a\uff0c\u5728BB-031\u7684\u6240\u6709\u6e2c\u8a66\u5291\u91cf\u4e0b\uff0c\u5f9e\u51dd\u8840\u6291\u5236\u7684\u5291\u91cf\u4f9d\u8cf4\u6027\u6301\u7e8c\u671f\u5230\u6062\u5fa9\u6b63\u5e38\u51dd\u8840\u7684\u6642\u9593\u6bb5\u5167\u53ef\u4ee5\u5b8c\u5168\u6291\u5236\u51dd\u584a\u7684\u5f62\u6210\u3002<\/p>\n<p>\u7279\u79d1\u7f85\u5728\u7814\u65b0\u85e5\u62ab\u9732\u65b0\u9032\u5c55\uff1a\u7279\u61c9\u6027\u76ae\u708e\u5c0f\u5206\u5b50\u85e5\u7269\u958b\u5553\u5291\u91cf\u905e\u589e\u4e00\u671f\u81e8\u5e8a\u8a66\u9a57<\/p>\n<p>\u7f8e\u570b\u592a\u5e73\u6d0b\u6642\u95932023\u5e742\u67088\u65e5\uff0c\u7531\u7dad\u4e9e\u751f\u7269\u53c3\u8207\u6295\u8cc7\u5b75\u5316\u7684\uff0c\u5c08\u6ce8\u65bc\u76ae\u819a\u65b0\u85e5\u7814\u767c\u7684\u5609\u8208\u7279\u79d1\u7f85\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\uff08\u4ee5\u4e0b\u7c21\u7a31\u300c\u7279\u79d1\u7f85\u300d\uff09\u6b63\u5f0f\u5ba3\u5e03\uff0c\u5df2\u5553\u52d5\u5176\u91dd\u5c0d\u7279\u61c9\u6027\u76ae\u708e\/\u6fd5\u75b9\u7684TDM-180935\u5916\u7528\u8edf\u818f\u7684\u4e00\u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u958b\u59cb\u5c0d\u5065\u5eb7\u7684\u81ea\u9858\u53d7\u8a66\u8005\u7528\u85e5\u3002<\/p>\n<p>\u95dc\u65bc\u7dad\u4e9e\u751f\u7269<\/p>\n<p>\u7dad\u4e9e\u751f\u7269(01873. HK)\u6210\u7acb\u65bc2008\u5e74\uff0c\u5411\u5168\u7403\u5275\u65b0\u85e5\u7814\u767c\u4f01\u696d\u63d0\u4f9b\u5f9e\u65e9\u671f\u57fa\u65bc\u7d50\u69cb\u7684\u85e5\u7269\u7814\u767c\u5230\u5546\u696d\u5316\u85e5\u7269\u4ea4\u4ed8\u7684\u4e00\u7ad9\u5f0f\u7d9c\u5408\u670d\u52d9\u3002\u6191\u85c9\u5728\u57fa\u65bc\u7d50\u69cb\u7684\u85e5\u7269\u7814\u767c(SBDD)\u6280\u8853\u9818\u57df\u7684\u9818\u5148\u512a\u52e2\uff0c\u6211\u5011\u5411\u5168\u7403\u5408\u4f5c\u5925\u4f34\u63d0\u4f9b\u65b0\u85e5\u7814\u7a76\u968e\u6bb5\u7684CRO\u670d\u52d9\uff0c\u642d\u5efa\u4e86X\u5c04\u7dab\u86cb\u767d\u6676\u9ad4\u6280\u8853\u3001\u51b7\u51cd\u96fb\u93e1\u6280\u8853(Cryo-EM)\u3001\u89aa\u548c\u529b\u8cea\u8b5c\u7be9\u9078\u6280\u8853(ASMS)\u3001\u8868\u9762\u7b49\u96e2\u5b50\u5171\u632f\u6280\u8853(SPR)\u3001\u6c2b\u6c18\u4ea4\u63db\u8cea\u8b5c\u6280\u8853(HDX-MS)\u3001\u8a08\u7b97\u6a5f\u8f14\u52a9\u85e5\u7269\u8a2d\u8a08\u7b49\u591a\u500b\u5148\u9032\u6280\u8853\u5e73\u53f0\uff0c\u4e26\u6709\u8cc7\u6df1\u85e5\u7269\u5316\u5b78\u5bb6\u8207\u85e5\u7269\u767c\u73fe\u751f\u7269\u5c08\u5bb6\u9818\u8ecd\u7684\u5718\u968a\u63d0\u4f9b\u85e5\u7269\u8a2d\u8a08\u3001\u85e5\u7269\u5316\u5b78(H2L\u3001LO)\u3001\u5316\u5408\u7269\u5408\u6210\u3001\u5316\u5b78\u5206\u6790\u53ca\u7d14\u5316\u3001\u516c\u65a4\u7d1a\u653e\u5927\u53ca\u591a\u80bd\u5408\u6210\u53ca\u76f8\u61c9\u7684\u751f\u7269\u6d3b\u6027\u6e2c\u8a66\u670d\u52d9\u3002\u901a\u904e\u5b50\u516c\u53f8\u6717\u83ef\u88fd\u85e5\uff0c\u6211\u5011\u63d0\u4f9b\u5f9e\u81e8\u5e8a\u524d\u958b\u767c\u5230\u5546\u696d\u5316\u751f\u7523\u7684\u4e00\u7ad9\u5f0fCMC\/CDMO\u89e3\u51b3\u65b9\u6848\u3002\u540c\u6642\uff0c\u6211\u5011\u5c08\u6ce8\u65bc\u767c\u73fe\u3001\u6295\u8cc7\u9ad8\u6f5c\u529b\u751f\u7269\u91ab\u85e5\u521d\u5275\u516c\u53f8\uff0c\u4ee5\u7368\u5275\u7684\u6280\u8853\u670d\u52d9\u63db\u53d6\u80a1\u6b0a(EFS)\u7684\u5546\u696d\u6a21\u5f0f\uff0c\u89e3\u51b3\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u3002<\/p>\n<p>\u95dc\u65bcMediar<\/p>\n<p>Mediar Therapeutics\u662f\u4e00\u5bb6\u65e8\u5728\u958b\u5275\u4e00\u7a2e\u6cbb\u7642\u7e96\u7dad\u5316\u7684\u65b0\u65b9\u6cd5\uff0c\u5f9e\u4e0d\u540c\u7684\u6e90\u982d&#8211;\u63a8\u52d5\u75be\u75c5\u9032\u5c55\u7684\u7e96\u7dad\u5316\u4ecb\u8cea&#8211;\u4f86\u963b\u6b62\u75be\u75c5\u767c\u5c55\u7684\u751f\u7269\u6280\u8853\u516c\u53f8\u3002Mediar\u516c\u53f8\u7684\u6210\u7acb\u662f\u57fa\u65bc\u5c0d\u7e96\u7dad\u5316\u767c\u75c5\u548c\u9032\u5c55\u7684\u8907\u96dc\u79d1\u5b78\u7684\u6df1\u523b\u7406\u89e3\u3002\u901a\u904e\u5c07\u65b0\u7684\u76ee\u6a19\u8207\u53ef\u9760\u7684\u3001\u6613\u65bc\u6aa2\u6e2c\u7684\u8840\u6db2\u751f\u7269\u6a19\u5fd7\u7269\u548c\u6210\u719f\u7684\u5206\u5b50\u985e\u578b\u76f8\u7d50\u5408\uff0cMediar\u6b63\u5728\u7232\u81e8\u5e8a\u958b\u767c\u4e2d\u7684\u7e96\u7dad\u5316\u7642\u6cd5\u7684\u767c\u5c55\u9053\u8def\u964d\u4f4e\u98a8\u96aa\u3002<\/p>\n<p>\u95dc\u65bc\u00a0AmacaThera<\/p>\n<p>AmacaThera Inc\uff0c\u4e00\u5bb6\u81e8\u5e8a\u968e\u6bb5\u7684\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u901a\u904e\u6539\u8b8a\u6cbb\u7642\u65b9\u5f0f\uff0c\u6539\u5584\u60a3\u8005\u5065\u5eb7\u3002AmacaGel\u2122\u662f\u516c\u53f8\u7368\u7279\u7684\u6ce8\u5c04\u6c34\u51dd\u81a0\u5e73\u53f0\uff0c\u53ef\u4ee5\u63d0\u4f9b\u5c40\u90e8\u7684\u85e5\u7269\u8f38\u9001\u4ee5\u53ca\u5be6\u73fe\u85e5\u7269\u7684\u7de9\u91cb\uff0c\u5f9e\u800c\u6539\u5584\u591a\u500b\u6cbb\u7642\u9818\u57df\u7684\u75be\u75c5\uff0c\u5305\u62ec\u8853\u5f8c\u75bc\u75db\u7ba1\u7406\u3001\u764c\u75c7\u548c\u5176\u4ed6\u96e3\u4ee5\u5230\u9054\u7684\u76ee\u6a19\u9818\u57df\u3002\u6b32\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\u00a0<a href=\"https:\/\/www.amacathera.ca\/\" target=\"_blank\" rel=\"noopener\">https:\/\/www.amacathera.ca<\/a><\/p>\n<p>\u95dc\u65bcQurAlis<\/p>\n<p>QurAlis\u958b\u62d3\u6027\u5730\u7814\u767c\u6cbb\u7642\u808c\u840e\u7e2e\u5074\u7d22\u786c\u5316\u75c7(ALS)\u548c\u5176\u4ed6\u795e\u7d93\u9000\u884c\u6027\u75be\u75c5\u7684\u65b0\u4e00\u4ee3\u7cbe\u51c6\u85e5\u7269\u3002\u6e90\u65bc\u5c0d\u81f4\u75c5\u57fa\u56e0\u6df1\u5165\u7684\u7814\u7a76\uff0cQurAlis\u4f9d\u6258\u65bc\u751f\u7269\u6a19\u8a18\u7269\u767c\u73fe\u548c\u7368\u6709\u7684\u7814\u767c\u5e73\u53f0\uff0c\u5c0d\u795e\u7d93\u9000\u884c\u6027\u75be\u75c5\u9032\u884c\u7cbe\u51c6\u6cbb\u7642\u3002\u516c\u53f8\u7531\u570b\u969b\u4e00\u6d41\u7684\u3001\u4f86\u81ea\u65bc\u54c8\u4f5b\u5927\u5b78\u548c\u54c8\u4f5b\u91ab\u5b78\u9662\u7684\u795e\u7d93\u751f\u7269\u5b78\u5c08\u5bb6\u5275\u7acb\uff0c\u76ee\u524d\u5df2\u642d\u5efa\u5305\u62ec\u6838\u9178\u548c\u5c0f\u5206\u5b50\u591a\u500b\u9805\u76ee\u7684\u7814\u767c\u7ba1\u7dab\uff0c\u81f4\u529b\u65bc\u958b\u767c\u89e3\u51b3ALS\u4e2d\u4e3b\u8981\u4e9e\u578b\u7684\u6cbb\u7642\u65b0\u65b9\u6cd5\u3002\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f <a href=\"http:\/\/www.quralis.com\/\" target=\"_blank\" rel=\"noopener\">www.quralis.com<\/a>\u00a0<\/p>\n<p>\u95dc\u65bcAceLink Therapeutics<\/p>\n<p>\u5275\u7acb\u65bc2018\u5e74\uff0cAceLinkTherapeutics\u662f\u4e00\u5bb6\u5275\u65b0\u578b\u751f\u7269\u88fd\u85e5\u521d\u5275\u4f01\u696d\uff0c\u5c08\u6ce8\u65bc\u958b\u767c\u5b89\u5168\u6709\u6548\u7684\u85e5\u7269\u4f86\u89e3\u51b3\u9700\u6c42\u672a\u5f97\u5230\u6eff\u8db3\u7684\u907a\u50b3\u75be\u75c5\u3002\u516c\u53f8\u9996\u8981\u7684\u91cd\u9ede\u662f\u958b\u767c\u6cbb\u7642\u6cd5\u5e03\u91cc\u75c5\u7684\u65b0\u7642\u6cd5\u3002\u7372\u53d6\u66f4\u591a\u4fe1\u606f\u8acb\u8a2a\u554f\uff1a<a href=\"http:\/\/www.acelinktherapeutics.com\/\" target=\"_blank\" rel=\"noopener\">www.acelinktherapeutics.com<\/a><\/p>\n<p>\u95dc\u65bcBasking Biosciences<\/p>\n<p>Basking Biosciences\u662f\u4e00\u5bb6\u8655\u65bc\u81e8\u5e8a\u968e\u6bb5\u7684\u516c\u53f8\uff0c\u65e8\u5728\u89e3\u51b3\u7f3a\u8840\u6027\u8166\u5352\u4e2d\u6cbb\u7642\u7684\u6700\u5927\u9700\u6c42 &#8212; \u4e00\u7a2e\u5feb\u901f\u8d77\u6548\u7684\u77ed\u6548\u6eb6\u6813\u85e5\u7269\uff0c\u80fd\u591f\u63d0\u4f9b\u6bd4\u73fe\u6709\u7642\u6cd5\u5927\u5927\u5ef6\u9577\u7684\u6cbb\u7642\u7a97\u53e3\uff0c\u4e26\u91cd\u65b0\u758f\u901a\u963b\u585e\u7684\u52d5\u8109\uff0c\u4e26\u4e14\u5728\u51fa\u8840\u6642\u53ef\u4ee5\u8fc5\u901f\u88ab\u9006\u8f49\u6d3b\u6027\u3002\u516c\u53f8\u6b63\u5728\u958b\u767c\u9818\u5148\u85e5\u7269BB-031\uff0c\u5373\u662f\u9019\u7a2eFirst -in-class RNA\u9069\u914d\u9ad4\uff0c\u9776\u5411\u8840\u6813\u7684\u91cd\u8981\u7d50\u69cb\u6210\u5206\u548c\u51dd\u8840\u904e\u7a0b\u7684\u9a45\u52d5\u56e0\u7d20\u8840\u7ba1\u6027\u8840\u53cb\u75c5\u56e0\u5b50(von Willebrand Factor, vWF)\u3002<\/p>\n<p>\u95dc\u65bc\u7279\u79d1\u7f85\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8<\/p>\n<p>\u7279\u79d1\u7f85\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\u662f\u4e00\u5bb6\u79c1\u7acb\u81e8\u5e8a\u968e\u6bb5\u7684\u751f\u7269\u91ab\u85e5\u516c\u53f8\uff0c\u7e3d\u90e8\u4f4d\u65bc\u5609\u8208\u79c0\u6d32\u751f\u7269\u91ab\u85e5\u570b\u5343\u5712\u3002\u516c\u53f8\u76ee\u524d\u7684\u6838\u5fc3\u7814\u767c\u9805\u76ee\u5305\u62ec\u91dd\u5c0d\u6cbb\u7642\u96c4\u6fc0\u7d20\u6027\u812b\u9aee\u3001\u7279\u61c9\u6027\u76ae\u708e\/\u6fd5\u75b9\u3001\u9280\u5c51\u75c5\u548c\u7d05\u6591\u72fc\u7621\u7b49\u75be\u75c5\u7684\u5275\u65b0\u7642\u6cd5\u3002\u5176\u5168\u7403\u9818\u5148\u7684\u6cbb\u7642\u96c4\u6fc0\u7d20\u6027\u812b\u9aee\u7684\u5c0f\u5206\u5b50\u5019\u9078\u85e5\u7269TDM-105795\u5373\u5c07\u958b\u59cb\u4e8c\u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u91dd\u5c0d\u7279\u61c9\u6027\u76ae\u708e\/\u6fd5\u75b9\u7684\u5275\u65b0\u578bJAK1\/TYK2\u6291\u5236\u5291\u5df2\u7d93\u958b\u59cb\u4e00\u671f\u81e8\u5e8a\u8a66\u9a57\u3002\u516c\u53f8\u5728\u7814\u7ba1\u7dab\u7523\u54c1\u90fd\u662f\u91dd\u5c0d\u6cbb\u7642\u5404\u7a2e\u76ae\u819a\u9069\u61c9\u75c7\u3002<\/p>","protected":false},"excerpt":{"rendered":"<p>\u9999\u6e2f2023\u5e744\u67084\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u9762\u5c0d\u4e0d\u65b7\u8b8a\u5316\u7684\u5c40\u52e2\uff0c\u6280\u8853\u5275\u65b0\u4f9d\u820a\u662f\u751f\u7269\u91ab\u85e5\u4f01\u696d\u9577\u9060\u767c\u5c55\u6c38\u6052\u7684\u4e3b\u65cb\u5f8b\uff0c\u7232\u4f01\u696d\u6e90\u6e90\u4e0d\u65b7\u5730\u6ce8\u5165\u751f\u547d\u529b\uff0c\u6301\u7e8c\u63a8\u52d5\u7814\u767c\u300c\u5f9e0\u52301\u300d\u8f49\u5316\u4ee5\u53ca\u5546\u696d\u5316\u6210\u529f\u3002\u8fd1\u671f\uff0c\u7dad\u4e9e6\u5bb6\u6295\u8cc7\u5b75\u5316\u4f01\u696d\u53d6\u5f97\u4e86\u986f\u8457\u7684\u6210\u679c\u8207\u9032\u5c55\uff1aMediar\u3001QurAlis\u6210\u529f\u5b8c\u6210\u878d\u8cc7\uff1bAmacaThera\u3001AceLink\u3001Basking\u53ca\u7279\u79d1\u7f85\u7814\u767c\u7ba1\u7dab\u9032\u5c55\u9806\u5229\u3002\u4e0b\u9762\uff0c\u8b93\u6211\u5011\u5171\u540c\u4e00\u89bd\u4ed6\u5011\u7684\u767c\u5c55\u52d5\u614b\u3002 Mediar Therapeutics\u5ba3\u5e03\u5b8c\u62101.05\u5104\u7f8e\u5143\u7684\u878d\u8cc7\uff0c\u4ee5\u63a8\u9032\u9996\u5275\u6297\u7e96\u7dad\u5316\u7642\u6cd5 3\u670815 &#8230; <\/p>\n<p class=\"read-more-container\"><a title=\"\u7dad\u4e9e\u751f\u72696\u5bb6\u6295\u8cc7\u5b75\u5316\u516c\u53f8\u8fd1\u671f\u767c\u5c55\u52d5\u614b\u4e00\u89bd\" class=\"read-more button\" href=\"https:\/\/www.franchise.com.hk\/zh-hans\/%e7%b6%ad%e4%ba%9e%e7%94%9f%e7%89%a96%e5%ae%b6%e6%8a%95%e8%b3%87%e5%ad%b5%e5%8c%96%e5%85%ac%e5%8f%b8%e8%bf%91%e6%9c%9f%e7%99%bc%e5%b1%95%e5%8b%95%e6%85%8b%e4%b8%80%e8%a6%bd\/12036#more-12036\" aria-label=\"\u66f4\u591a 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