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<\/p>\n<p>\u7814\u767c\u9805\u76ee<\/p>\n<p>\u767e\u6085\u6fa4\u00ae\uff08\u6fa4\u5e03\u66ff\u5c3c\uff09\uff1a\u4e00\u6b3e\u65e8\u5728\u6700\u5927\u5316\u5e03\u9b6f\u9813\u6c0f\u916a\u6c28\u9178\u6fc0\u9176\uff08BTK\uff09\u4f54\u6709\u7387\u3001\u6700\u5c0f\u5316\u812b\u9776\u6548\u61c9\u7684\u5c0f\u5206\u5b50BTK\u6291\u5236\u5291\uff0c\u5df2\u5728\u7f8e\u570b\u3001\u4e2d\u570b\u3001\u6b50\u76df\u3001\u82f1\u570b\u3001\u52a0\u62ff\u5927\u3001\u6fb3\u5927\u5229\u4e9e\u3001\u97d3\u570b\u548c\u745e\u58eb\u5728\u5167\u768458\u500b\u5e02\u5834\u7372\u6279\u591a\u9805\u9069\u61c9\u75c7\uff0c\u76ee\u524d\u6b63\u5728\u9032\u4e00\u6b65\u81e8\u5e8a\u958b\u767c\uff0c\u4ee5\u5728\u5168\u7403\u7bc4\u570d\u5167\u53d6\u5f97\u66f4\u591a\u4e0a\u5e02\u6279\u51c6\u3002\u767e\u6085\u6fa4\u00ae\u5168\u7403\u958b\u767c\u9805\u76ee\u5df2\u5728\u8d85\u904e25\u500b\u570b\u5bb6\u548c\u5730\u5340\u5165\u7d44\u8d85\u904e4,700\u4f8b\u53d7\u8a66\u8005\u3002<\/p>\n<p>\u5ba3\u4f48\u5728\u5168\u74033\u671fALPINE\u8a66\u9a57\u7684\u4e00\u9805\u7d42\u671f\u5206\u6790\u4e2d\uff0c\u7d93\u7368\u7acb\u8a55\u5be9\u59d4\u54e1\u6703\uff08IRC\uff09\u53ca\u7814\u7a76\u8005\u8a55\u4f30\uff0c\u767e\u6085\u6fa4\u00ae\u5c0d\u6bd4\u5104\u73c2\u00ae\uff08\u4f0a\u5e03\u66ff\u5c3c\uff09\uff0c\u53d6\u5f97\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u7684\u512a\u6548\u6027\u7d50\u679c\uff1b   \u7372\u5f97\u6b50\u76df\u59d4\u54e1\u6703\u6279\u51c6\uff0c\u7528\u65bc\u6cbb\u7642\u908a\u7de3\u5340\u6dcb\u5df4\u7624\uff08MZL\uff09\uff0c\u9019\u6a19\u8a8c\u8457\u767e\u6085\u6fa4\u00ae\u6210\u70ba\u9996\u500b\u4e14\u552f\u4e00\u5728\u6b50\u76df\u5730\u5340\u7372\u6279\u7528\u65bcMZL\u6cbb\u7642\u7684BTK\u6291\u5236\u5291\uff1b   \u7372\u5f97\u6b50\u6d32\u85e5\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u4eba\u7528\u85e5\u54c1\u59d4\u54e1\u6703\uff08CHMP\uff09\u7684\u7a4d\u6975\u610f\u898b\uff0c\u5176\u5efa\u8b70\u6279\u51c6\u767e\u6085\u6fa4\u00ae\u7528\u65bc\u6cbb\u7642\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08CLL\uff09\u6210\u4eba\u60a3\u8005\uff1b   \u63a8\u52d5\u767e\u6085\u6fa4\u00ae\u7684\u5168\u7403\u85e5\u653f\u8a3b\u518a\u9805\u76ee\uff0c\u5f9e\u800c\u5728\u65b0\u5730\u5340\u548c\u65b0\u9069\u61c9\u75c7\u4e2d\u9032\u4e00\u6b65\u62d3\u5c55\uff0c\u767e\u6085\u6fa4\u00ae\u4eca\u5e74\u4ee5\u4f86\u5df2\u572810\u500b\u65b0\u589e\u5e02\u5834\u4e0a\u5e02\u3002\u00a0  <\/p>\n<p>\u767e\u6fa4\u5b89\u00ae\uff08\u66ff\u96f7\u5229\u73e0\u55ae\u6297\uff09\uff1a\u4e00\u6b3e\u4eba\u6e90\u5316IgG4\u6297PD-1\u55ae\u514b\u9686\u6297\u9ad4\uff0c\u5176\u7d50\u69cb\u7d93\u7279\u6b8a\u6539\u9020\uff0c\u53ef\u6700\u5927\u9650\u5ea6\u6e1b\u5c11\u8207\u5de8\u566c\u7d30\u80de\u4e2d\u00a0Fc\u03b3\u53d7\u9ad4\u7d50\u5408\u3002\u767e\u6fa4\u5b89\u00ae\u5df2\u5728\u4e2d\u570b\u7372\u6279\u7528\u65bc9\u9805\u9069\u61c9\u75c7\uff0c\u76ee\u524d\u6b63\u5728\u9032\u4e00\u6b65\u958b\u767c\uff0c\u4ee5\u5728\u5168\u7403\u7bc4\u570d\u5167\u7372\u5f97\u66f4\u591a\u4e0a\u5e02\u6279\u51c6\u3002\u767e\u6fa4\u5b89\u00ae\u5168\u7403\u81e8\u5e8a\u958b\u767c\u9805\u76ee\u5df2\u572830\u500b\u570b\u5bb6\u548c\u5730\u5340\u5165\u7d44\u8d85\u904e11,500 \u4f8b\u53d7\u8a66\u8005\u3002\u91cd\u8981\u9032\u5c55\u5305\u62ec\uff1a<\/p>\n<p>\u5ba3\u4f48\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u5df2\u53d7\u7406\u4e00\u9805\u767e\u6fa4\u5b89\u00ae\u806f\u5408\u5316\u7642\uff0c\u7528\u65bc\u4e00\u7dda\u6cbb\u7642\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u3001\u5fa9\u767c\u6216\u8f49\u79fb\u6027\u98df\u7ba1\u9c57\u72c0\u7d30\u80de\u764c\uff08ESCC\uff09\u7684\u65b0\u9069\u61c9\u75c7\u4e0a\u5e02\u8a31\u53ef\u7533\u8acb\uff08sBLA\uff09\uff1b   \u767e\u6fa4\u5b89\u00ae\u7528\u65bc\u4e00\u7dda\u3001\u4e8c\u7dda\u6cbb\u7642\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u548c\u4e8c\u7dda\u6cbb\u7642\u98df\u7ba1\u764c\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\u5df2\u7372\u5f97\u7d10\u897f\u862d\u85e5\u54c1\u548c\u91ab\u7642\u5668\u68b0\u5b89\u5168\u7ba1\u7406\u5c40\uff08Medsafe\uff09\u53d7\u7406\uff0c\u76ee\u524d\u6b63\u5728\u5be9\u8a55\u4e2d\uff1b   \u767e\u6fa4\u5b89\u00ae\u7528\u65bc\u4e8c\u7dda\u6cbb\u7642\u98df\u7ba1\u764c\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\u5df2\u7372\u97d3\u570b\u98df\u54c1\u85e5\u54c1\u5b89\u5168\u90e8\uff08MFDS\uff09\u53d7\u7406\uff0c\u76ee\u524d\u6b63\u5728\u5be9\u8a55\u4e2d\uff1b   \u5ba3\u4f48\u767e\u6fa4\u5b89\u00ae\u5168\u74033\u671f\u81e8\u5e8a\u8a66\u9a57RATIONALE 301\u7814\u7a76\u9054\u5230\u4e3b\u8981\u7d42\u9ede\uff0c\u7528\u65bc\u4e00\u7dda\u6cbb\u7642\u4e0d\u53ef\u5207\u9664\u7684\u809d\u7d30\u80de\u764c\uff08HCC\uff09\u6210\u4eba\u60a3\u8005\uff0c\u767e\u6fa4\u5b89\u00ae\u8207\u7d22\u62c9\u975e\u5c3c\u76f8\u6bd4\uff0c\u5c55\u793a\u51fa\u5728\u7e3d\u751f\u5b58\u671f\u4e0a\u7684\u975e\u52a3\u6548\u6027\u3002\u57282022\u5e74\u6b50\u6d32\u816b\u7624\u5167\u79d1\u5b78\u6703\uff08ESMO 2022\uff09\u4e0a\uff0c\u9019\u4e9b\u8a66\u9a57\u7d50\u679c\u88ab\u63a5\u53d7\u70ba\u6700\u65b0\u6458\u8981\uff0c\u4e14\u5728\u53e3\u982d\u5831\u544a\u74b0\u7bc0\u9032\u884c\u5c55\u793a\uff1b   <span>\u5728ESMO 2022\u4e0a\uff0c\u901a\u904e\u6d77\u5831\u5c55\u793a\u4e86\u4e00\u9805\u767e\u6fa4\u5b89\u00ae\u7528\u65bc\u4e8c\u7dda\u6cbb\u7642NSCLC\u76843\u671f\u8a66\u9a57RATIONALE 303\u4e2d\uff0c\u5728\u9810\u5148\u8a2d\u5b9a\u7684\u4e9e\u7d44\u4e4b\u9593\u53d6\u5f97\u7684\u7de9\u89e3\u4e00\u81f4\u6027\u6578\u64da\uff1b<\/span>   \u57282022\u4e16\u754c\u80ba\u764c\u5927\u6703\uff08WCLC 2022\uff09\u4e0a\u516c\u4f48\u4e86\u6700\u65b0\u81e8\u5e8a\u6578\u64da\uff0c\u5305\u62ec\u767e\u6fa4\u5b89\u00ae\u4f5c\u70ba\u55ae\u85e5\uff0c\u8207\u5316\u7642\u5c0d\u6bd4\uff0c\u6cbb\u7642\u65e2\u5f80\u7d93\u6cbb\u7684\u665a\u671fNSCLC\u60a3\u8005\u7684\u5168\u74033\u671f\u8a66\u9a57\u00a0RATIONALE 303\uff08NCT03358875\uff09\u7684\u7d42\u671f\u5206\u6790\u7d50\u679c\u3002  <\/p>\n<p>\u6b50\u53f8\u73c0\u5229\u55ae\u6297\uff08BGB-A1217\uff09\uff1a\u4e00\u6b3e\u5177\u6709\u5b8c\u5584Fc\u529f\u80fd\u7684\u5728\u7814\u6297TIGIT\u55ae\u514b\u9686\u6297\u9ad4\u3002\u6b50\u53f8\u73c0\u5229\u55ae\u6297\u7684\u5168\u7403\u81e8\u5e8a\u958b\u767c\u9805\u76ee\u5df2\u5728\u8d85\u904e25\u500b\u570b\u5bb6\u548c\u5730\u5340\u5165\u7d44\u8d85\u904e1,500\u4f8b\u53d7\u8a66\u8005\u3002<\/p>\n<p>\u5728WCLC 2022\u4e0a\uff0c\u516c\u4f48\u4e86\u806f\u5408\u767e\u6fa4\u5b89\u00ae\u7528\u65bc\u6cbb\u7642\u8868\u9054PD-L1\u7684NSCLC\u60a3\u8005\u76841\u671f\u8a66\u9a57\uff08NCT04047862\uff09\u6578\u64da\uff1b   \u5728ESMO 2022\u4e0a\uff0c\u516c\u4f48\u4e86\u806f\u5408\u767e\u6fa4\u5b89\u00ae\u5c0d\u6bd4\u5316\u7642\uff0c\u7528\u65bc\u6cbb\u7642NSCLC\u60a3\u8005\u76841\u671f\u8a66\u9a57\u968a\u5217\u65b0\u589e\u6578\u64da\u3002  <\/p>\n<p>BGB-11417\uff1a\u4e00\u6b3e\u9ad8\u9078\u64c7\u6027\u3001\u5f37\u6548\u7684\u5728\u7814BCL-2\u6291\u5236\u5291\uff0c\u6b63\u4f5c\u70ba\u55ae\u85e5\u6216\u8207\u767e\u6085\u6fa4\u00ae\u806f\u5408\u7528\u85e5\u9032\u884c\u81e8\u5e8a\u958b\u767c\u3002BGB-11417\u7684\u5168\u7403\u81e8\u5e8a\u958b\u767c\u9805\u76ee\u5df2\u5728\u8d85\u904e10\u500b\u570b\u5bb6\u548c\u5730\u5340\u5165\u7d44\u8d85\u904e300\u4f8b\u53d7\u8a66\u8005\u3002\u00a0<\/p>\n<p>\u555f\u52d5\u91dd\u5c0d\u5fa9\u767c\u6216\u96e3\u6cbb\u6027\u5957\u7d30\u80de\u6dcb\u5df4\u7624\u60a3\u8005\u76842\u671f\u7814\u7a76\uff08NCT05471843\uff09\u7684\u60a3\u8005\u7d66\u85e5\u5de5\u4f5c\uff0c\u4ee5\u8a55\u4f30BCL-2\u6291\u5236\u5291BGB-11417\u7684\u6548\u679c\uff1b   \u5728\u4e2d\u570b\u555f\u52d5\u55ae\u81c22\u671f\u7814\u7a76BGB-11417-202\u7684\u60a3\u8005\u7d66\u85e5\u5de5\u4f5c\uff0c\u4ee5\u8a55\u4f30BGB-11417\u7528\u65bc\u6cbb\u7642R\/R CLL\/SLL\u60a3\u8005\u7684\u6548\u679c\u3002  <\/p>\n<p>\u65e9\u671f\u81ea\u4e3b\u7814\u767c\u9805\u76ee<\/p>\n<p>\u555f\u52d5BGB-B167\u76841\u671f\u8a66\u9a57\uff08NCT05494762\uff09\u7684\u60a3\u8005\u7d66\u85e5\u5de5\u4f5c\uff0cBGB-B167\u662f\u4e00\u6b3e\u5728\u7814\u3001\u6f5b\u5728&#8221;\u540c\u985e\u9996\u5275&#8221;CEAx4-1BB\u96d9\u7279\u7570\u6027\u6297\u9ad4\u85e5\u7269\uff0c\u4f5c\u70ba\u55ae\u85e5\u6216\u806f\u5408\u767e\u6fa4\u5b89\u00ae\u6cbb\u7642\u9078\u64c7\u6027\u8868\u9054CEA\u7684\u665a\u671f\u6216\u8f49\u79fb\u6027\u5be6\u9ad4\u7624\uff0c\u5305\u62ec\u7d50\u76f4\u8178\u764c\uff08CRC\uff09\uff1b\u00a0   \u555f\u52d5\u6297TIM3\u6297\u9ad4surzebiclimab\uff08BGB-A425\uff09\u4e00\u9805\u806f\u5408\u767e\u6fa4\u5b89\u00ae\u7528\u65bc\u6cbb\u7642NSCLC\u548c\u982d\u9838\u90e8\u9c57\u72c0\u7d30\u80de\u764c\uff08HNSCC\uff09\u816b\u7624\u7279\u7570\u6027\u4f47\u5217\uff08NCT03744468\uff09\u7814\u7a76\u7684\u60a3\u8005\u5165\u7d44\u5de5\u4f5c\uff1b\u00a0   \u7e7c\u7e8c\u63a8\u9032\u65e9\u671f\u81e8\u5e8a\u7ba1\u7dda\u4e2d\u81ea\u4e3b\u7814\u767c\u5019\u9078\u85e5\u7269\u7684\u5291\u91cf\u905e\u589e\u968e\u6bb5\u7814\u7a76\uff0c\u5305\u62ec\uff1a  <\/p>\n<p class=\"prnml80\">&#8211;\u00a0 BGB-A445\uff1a\u4e00\u6b3e\u5728\u7814\u975e\u914d\u9ad4\u7af6\u722d\u6027\u6297OX40\u55ae\u514b\u9686\u6297\u9ad4\uff0c\u4f5c\u70ba\u55ae\u85e5\u6cbb\u7642NSCLC\u548cHNSCC\u816b\u7624\u7279\u7570\u6027\u4f47\u5217\uff0c\u6216\u806f\u5408\u767e\u6fa4\u5b89\u00ae\u6cbb\u7642\u665a\u671f\u5be6\u9ad4\u7624\uff1b<\/p>\n<p class=\"prnml80\">&#8211;\u00a0 BGB-15025\uff1a\u4e00\u6b3e\u4f5c\u70ba\u55ae\u85e5\u6216\u806f\u5408\u767e\u6fa4\u5b89\u00ae\u6cbb\u7642\u5be6\u9ad4\u7624\u7684\u5728\u7814\u3001\u6f5b\u5728&#8221;\u540c\u985e\u9996\u5275&#8221;\u7684\u9020\u8840\u5e79\u7d30\u80de\u6fc0\u91761\uff08HPK1\uff09\u6291\u5236\u5291\uff1b<\/p>\n<p class=\"prnml80\">&#8211;\u00a0 BGB-16673\uff1a\u4e00\u6b3e\u5728\u7814\u5d4c\u5408\u5f0f\u964d\u89e3\u555f\u52d5\u5316\u5408\u7269\uff08CDAC\uff09\uff0c\u9776\u5411BTK\u86cb\u767d\u964d\u89e3\uff0c\u4f5c\u70ba\u55ae\u85e5\u6cbb\u7642B\u7d30\u80de\u60e1\u6027\u816b\u7624\uff1b<\/p>\n<p class=\"prnml80\">&#8211;\u00a0 BGB-24714\uff1a\u4e00\u6b3e\u5728\u7814\u7684\u7b2c\u4e8c\u7dda\u7c92\u9ad4\u4f86\u6e90\u534a\u80f1\u6c28\u9178\u86cb\u767d\u9176\u6fc0\u6d3b\u5291\uff08SMAC\uff09\u6a21\u64ec\u7269\uff0c\u4f5c\u70ba\u55ae\u85e5\u6216\u806f\u5408\u7d2b\u6749\u9187\u7528\u65bc\u6cbb\u7642\u665a\u671f\u5be6\u9ad4\u7624\uff1b<\/p>\n<p class=\"prnml80\">&#8211;\u00a0 BGB-10188\uff1a\u4e00\u6b3e\u4f5c\u70ba\u55ae\u85e5\u6216\u806f\u5408\u767e\u6085\u6fa4\u00ae\u6cbb\u7642\u8840\u6db2\u60e1\u6027\u816b\u7624\uff0c\u6216\u806f\u5408\u767e\u6fa4\u5b89\u00ae\u6cbb\u7642\u5be6\u9ad4\u7624\u7684\u5728\u7814PI3K\u03b4\u6291\u5236\u5291\uff1b<\/p>\n<p class=\"prnml80\">&#8211;\u00a0 BGB-23339\uff1a\u4e00\u6b3e\u5728\u7814\u5f37\u6548\u916a\u6c28\u9178\u6fc0\u91762\uff08TYK2\uff09\u8b8a\u69cb\u6291\u5236\u5291\u3002<\/p>\n<p>\u5408\u4f5c\u9805\u76ee<\/p>\n<p><span>\u8207\u5357\u4eac\u7dad\u7acb\u5fd7\u535a\u5408\u4f5c\uff0c\u5c0d\u767e\u6fdf\u795e\u5dde\u7533\u8fa6\u7684LAG3\u6291\u5236\u5291LBL-007\u8207\u767e\u6fa4\u5b89\u00ae\u806f\u5408\u6cbb\u7642\u665a\u671f\u5be6\u9ad4\u7624\u7684900-102\u81e8\u5e8a\u8a66\u9a57\uff08NCT03744468\uff09\u958b\u59cb\u60a3\u8005\u7d66\u85e5\u3002<\/span>  <\/p>\n<p>\u751f\u7522\u904b\u71df<\/p>\n<p>\u7e7c\u7e8c\u5efa\u8a2d\u4f4d\u65bc\u7f8e\u570b\u65b0\u6fa4\u897f\u5dde\u970d\u666e\u97cb\u723e\u666e\u6797\u65af\u9813\u897f\u90e8\u5275\u65b0\u5712\u5340\u7684\u65d7\u8266\u7d1a\u5546\u696d\u5316\u968e\u6bb5\u751f\u7522\u57fa\u5730\u548c\u81e8\u5e8a\u7814\u767c\u4e2d\u5fc3\u3002\u8a72\u57fa\u5730\u9810\u7559\u4e86\u8d85\u904e100\u842c\u5e73\u65b9\u82f1\u5c3a\uff08\u7d049.3\u842c\u5e73\u65b9\u7c73\uff09\u7684\u53ef\u958b\u767c\u5730\u7522\uff0c\u4ee5\u5099\u7528\u4e8e\u672a\u4f86\u7684\u9032\u4e00\u6b65\u62d3\u5c55\uff1b   \u7e7c\u7e8c\u5efa\u8a2d\u4f4d\u65bc\u4e2d\u570b\u8607\u5dde\u7684\u65b0\u5efa\u5c0f\u5206\u5b50\u5275\u65b0\u85e5\u7269\u7522\u696d\u5316\u57fa\u5730\u3002\u7b2c\u4e00\u968e\u6bb5\u7684\u5efa\u8a2d\u9762\u7a4d\u9810\u8a08\u5c07\u8d85\u904e52,000\u5e73\u65b9\u7c73\uff0c\u56fa\u9ad4\u5236\u5291\u7522\u80fd\u53ef\u64f4\u5927\u81f3 6\u5104\u7247\uff08\u7c92\uff09\u5291\u6b21\uff0c\u8a72\u9805\u76ee\u9810\u8a08\u65bc2023\u5e74\u5b8c\u5de5\u3002\u5f85\u57fa\u5730\u5efa\u8a2d\u5b8c\u6210\u3001\u9a57\u6536\u5408\u683c\u4e26\u7372\u6279\u5f8c\uff0c\u9810\u8a08\u6211\u5011\u5728\u4e2d\u570b\u7684\u5c0f\u5206\u5b50\u85e5\u7269\u751f\u7522\u80fd\u529b\u6700\u9ad8\u5c07\u63d0\u5347\u81f3\u76ee\u524d\u768410\u500d\uff1b   \u7e7c\u7e8c\u5efa\u8a2d\u4f4d\u65bc\u4e2d\u570b\u5ee3\u5dde\u7684\u4e16\u754c\u4e00\u6d41\u751f\u7269\u85e5\u751f\u7522\u57fa\u5730\uff0c\u8a72\u57fa\u5730\u76ee\u524d\u5df2\u7372\u6279\u751f\u7269\u85e5\u7522\u80fd\u70ba16,000\u5347\uff0c\u65b0\u4e00\u968e\u6bb5\u5efa\u8a2d\u9810\u8a08\u5c07\u65bc2022\u5e74\u5e95\u5b8c\u5de5\u4e26\u6eff\u8db3GMP\u6a19\u6e96\uff0c\u5c46\u6642\u7522\u80fd\u5c07\u9054\u523054,000\u5347\u3002\u622a\u81f32023\u5e74\u7b2c\u4e8c\u5b63\u5ea6\uff0c\u8a72\u968e\u6bb5\u5efa\u8a2d\u7684\u7522\u80fd\u5c07\u984d\u5916\u589e\u52a010,000\u5347\u3002  <\/p>\n<p><span>\u4f01\u696d\u767c\u5c55<\/span><\/p>\n<p><span>\u8207<\/span>McKesson\u65d7\u4e0bOntada\u00ae\u516c\u53f8\u9054\u6210\u6230\u7565\u5354\u8b70\uff0cOntada\u00ae\u516c\u53f8\u662f\u4e00\u5bb6\u5728\u816b\u7624\u5b78\u9818\u57df\u64c1\u6709\u9818\u5148\u6280\u8853\u548c\u53ef\u64cd\u4f5c\u7684\u771f\u5be6\u4e16\u754c\u7814\u7a76\u3001\u6559\u80b2\u548c\u8b49\u64da\u7684\u670d\u52d9\u63d0\u4f9b\u8005\uff0c\u96d9\u65b9\u5c07\u901a\u904e\u958b\u767c\u771f\u5be6\u4e16\u754c\u8b49\u64da\uff08RWE\uff09\u6578\u64da\u3001\u5de5\u5177\u548c\u6d1e\u5bdf\u4f86\u6539\u5584\u7f8e\u570b\u793e\u5340\u816b\u7624\u5b78\u8b77\u7406\uff0c\u4ee5\u63d0\u5347\u524d\u6cbf\u7642\u6cd5\u7684\u53ef\u53ca\u6027\u548c\u53ef\u8ca0\u64d4\u6027\u3002  <\/p>\n<p>\u9810\u8a08\u91cc\u7a0b\u7891\u4e8b\u4ef6\u00a0<\/p>\n<p>\u767e\u6085\u6fa4\u00ae\uff08\u6fa4\u5e03\u66ff\u5c3c\uff09<\/p>\n<p>\u7e7c\u7e8c\u652f\u6301FDA\u5c0d\u65bcCLL\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08SLL\uff09\u65b0\u9069\u61c9\u75c7\u4e0a\u5e02\u7533\u8acb\uff08sNDA\uff09\u7684\u5be9\u8a55\u5de5\u4f5c\u3002\u6839\u64da\u300a\u8655\u65b9\u85e5\u7533\u5831\u8005\u4ed8\u8cbb\u6cd5\u6848\u300b\uff08PDUFA\uff09\uff0cFDA\u5c0d\u8a72\u7533\u8acb\u505a\u51fa\u6c7a\u8b70\u7684\u76ee\u6a19\u6642\u9593\u70ba2023\u5e741\u6708\uff1b\u00a0   \u7e7c\u7e8c\u652f\u6301EMA\u548c\u6b50\u76df\u59d4\u54e1\u6703\u5c0dCLL\u65b0\u9069\u61c9\u75c7\u4e0a\u5e02\u7533\u8acb\u7684\u5be9\u8a55\u5de5\u4f5c\uff1b   \u7e7c\u7e8c\u652f\u6301\u52a0\u62ff\u5927\u885b\u751f\u90e8\u5c0dCLL\u7684sNDA\u7684\u5be9\u8a55\u5de5\u4f5c\uff1b\u00a0   \u7e7c\u7e8c\u652f\u6301NMPA\u5c0d\u4e00\u7ddaCLL\/SLL\u7684sNDA\u7684\u5be9\u8a55\u5de5\u4f5c\uff1b\u00a0   \u7e7c\u7e8c\u652f\u6301\u82f1\u570b\u85e5\u54c1\u8207\u4fdd\u5065\u54c1\u7ba1\u7406\u5c40\uff08MHRA\uff09\u548c\u745e\u58eb\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08Swissmedic\uff09\u5c0dMZL\u548cCLL\u65b0\u9069\u61c9\u75c7\u4e0a\u5e02\u7533\u8acb\u7684\u5be9\u8a55\u5de5\u4f5c\uff1b\u00a0   \u5c07\u65bc\u8fd1\u671f\u8209\u884c\u7684\u91ab\u5b78\u5927\u6703\u4e0a\u516c\u4f48\u5168\u74033\u671fALPINE\u8a66\u9a57\uff08NCT03734016\uff09\u7684\u7d42\u671f\u5206\u6790\u6578\u64da\uff0c\u5305\u62ec\u7121\u9032\u5c55\u751f\u5b58\u671f\u6578\u64da\uff1b   \u5c07\u65bc\u7b2c64\u5c46\u7f8e\u570b\u8840\u6db2\u5b78\u6703\uff08ASH\uff09\u5e74\u6703\u4e0a\uff0c\u5831\u544a\u767e\u6085\u6fa4\u00ae\u81e8\u5e8a\u958b\u767c\u9805\u76ee\u4e2d\u7684\u95dc\u9375\u6578\u64da\uff0c\u5305\u62ec\u53e3\u982d\u5831\u544a\u767e\u6085\u6fa4\u00ae\u7528\u65bc\u6cbb\u7642MZL\u60a3\u8005\u7684MAGNOLIA\u8a66\u9a57\u6578\u64da\uff0c\u4ee5\u53ca\u901a\u904e\u6d77\u5831\u5c55\u793a\u767e\u6085\u6fa4\u00ae\u7528\u65bc\u6cbb\u7642\u4e0d\u80fd\u8010\u53d7\u963f\u5361\u66ff\u5c3c\u7684B\u7d30\u80de\u60e1\u6027\u816b\u7624\u60a3\u8005\u7684\u6700\u65b0\u7d50\u679c\u3002\u6b64\u6b21\u6703\u8b70\u5c07\u65bc12\u670810\u65e5\u81f314\u65e5\uff0c\u5728\u7f8e\u570b\u65b0\u5967\u723e\u826f\u8209\u8fa6\u3002  <\/p>\n<p>\u767e\u6fa4\u5b89\u00ae\uff08\u66ff\u96f7\u5229\u73e0\u55ae\u6297\uff09<\/p>\n<p>\u7e7c\u7e8c\u652f\u6301NMPA\u5c0d\u65bc\u767e\u6fa4\u5b89\u00ae\u806f\u5408\u5316\u7642\u4e00\u7dda\u6cbb\u7642\u816b\u7624\u7d30\u80de\u8868\u9054\u00a0PD-L1\u7684\u665a\u671f\u6216\u8f49\u79fb\u6027\u80c3\u6216\u80c3\u98df\u7ba1\u7d50\u5408\u90e8\u817a\u764c\u60a3\u8005\uff0c\u4ee5\u53ca\u767e\u6fa4\u5b89\u00ae\u806f\u5408\u5316\u7642\u4e00\u7dda\u6cbb\u7642\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u3001\u5fa9\u767c\u6216\u8f49\u79fb\u6027\u98df\u7ba1\u9c57\u72c0\u7d30\u80de\u764c\uff08ESCC\uff09\u7684\u65b0\u9069\u61c9\u75c7\u4e0a\u5e02\u7533\u8acb\uff08BLA\uff09\u7684\u5be9\u8a55\u5de5\u4f5c\uff1b   \u7e7c\u7e8c\u5c31\u767e\u6fa4\u5b89\u00ae\u7528\u65bc\u4e00\u7dda\u6cbb\u7642\u809d\u7d30\u80de\u764c\u60a3\u8005\u7684sBLA\u8207NMPA\u4fdd\u6301\u6e9d\u901a\uff1b   \u7e7c\u7e8c\u652f\u6301\u76e3\u7ba1\u6a5f\u69cb\u5c0d\u65bc\u767e\u6fa4\u5b89\u00ae\u4e0a\u5e02\u7533\u8acb\u7684\u5be9\u8a55\u5de5\u4f5c\uff0c\u5305\u62ec\uff1a\u6fb3\u5927\u5229\u4e9eTGA\u548c\u7d10\u897f\u862dMedsafe\u5c0d\u767e\u6fa4\u5b89\u00ae\u7528\u65bc\u4e00\u7dda\u3001\u4e8c\u7dda\u6cbb\u7642NSCLC\u548c\u4e8c\u7dda\u6cbb\u7642ESCC\u7684BLA\u7684\u5be9\u8a55\uff1b\u97d3\u570bMFDS\u5c0d\u767e\u6fa4\u5b89\u00ae\u7528\u65bc\u4e8c\u7dda\u6cbb\u7642ESCC\u7684BLA\u7684\u5be9\u8a55\u5de5\u4f5c\uff1b   \u8207\u8afe\u83ef\u5408\u4f5c\uff0c\u7e7c\u7e8c\u652f\u6301\u767e\u6fa4\u5b89\u00ae\u7684\u4e0a\u5e02\u7533\u8acb\u5be9\u8a55\u5de5\u4f5c\uff0c<span>\u5305\u62ec\uff1a<\/span><\/p>\n<p class=\"prnml80\">&#8211;\u00a0 <span>FDA<\/span>\u6b63\u5728\u5be9\u8a55\u7684\u5c0d\u767e\u6fa4\u5b89\u00ae\u7528\u65bc\u4e8c\u7dda\u6cbb\u7642ESCC\u7684BLA\uff0c\u5305\u62ec\u5118\u65e9\u63a8\u52d5\u76f8\u95dc\u73fe\u5834\u6838\u67e5\u5de5\u4f5c\uff1b<\/p>\n<p class=\"prnml80\">&#8211;\u00a0 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\u745e\u58eb\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u5c0d\u65bc\u767e\u6fa4\u5b89\u00ae\u7528\u65bc\u4e8c\u7dda\u6cbb\u7642ESCC\u7684\u4e0a\u5e02\u8a31\u53ef\u7533\u8acb\u7684\u5be9\u8a55\u5de5\u4f5c\uff1b<\/p>\n<p>\u7e7c\u7e8c\u652f\u6301\u8afe\u83ef\u8a08\u756b\u4e8e2023\u5e74\u5411\u7f8e\u570bFDA\u905e\u4ea4\u767e\u6fa4\u5b89\u00ae\u7528\u65bc\u4e00\u7dda\u6cbb\u7642\u80c3\u764c\u3001\u4e00\u7dda\u6cbb\u7642\u4e0d\u53ef\u5207\u9664ESCC\u548c\u4e00\u7dda\u6cbb\u7642HCC\u7684\u85e5\u653f\u7533\u5831\u5de5\u4f5c\u3002\u00a0  <\/p>\n<p><span>BGB-11417<\/span>\uff08BCL-2\u6291\u5236\u5291\uff09<\/p>\n<p>\u5c07\u65bc2022\u5e74ASH\u5927\u6703\u4e0a\u5c55\u793a\u5176\u7528\u65bc\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08NHL\uff09\u3001CLL\u3001\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u548c\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08MM\uff09\u76841\u671f\u81e8\u5e8a\u8a66\u9a57\u6578\u64da\uff08NCT04883957\u3001NCT04277637\u3001NCT04771130 \u548c NCT04973605\uff09\u3002  <\/p>\n<p>\u5408\u4f5c\u9805\u76ee\u00a0<\/p>\n<p>\u8207Zymeworks\u5408\u4f5c\uff0c\u65bc2022\u5e74\u5167\u516c\u4f48zanidatamab\u7528\u65bc\u6cbb\u7642\u665a\u671f\u6216\u8f49\u79fb\u6027HER2\u64f4\u589e\u81bd\u9053\u764c2b\u671f\u81e8\u5e8a\u7814\u7a76\uff08NCT04466891\uff09\u7684\u4e3b\u8981\u7d50\u679c\u3002\u00a0  <\/p>\n<p>\u65b0\u51a0\u80ba\u708e\u75ab\u60c5\u5f71\u97ff\u53ca\u61c9\u5c0d\u63aa\u65bd<\/p>\n<p>\u6211\u5011\u9810\u8a08\u65b0\u51a0\u80ba\u708e\u75ab\u60c5\u6240\u5f15\u8d77\u7684\u5168\u7403\u885b\u751f\u5371\u6a5f\u5c07\u7e7c\u7e8c\u5c0d\u6211\u5011\u7684\u696d\u52d9\u9020\u6210\u4e00\u5b9a\u7684\u8ca0\u9762\u5f71\u97ff\uff0c\u5305\u62ec\u5546\u696d\u92b7\u552e\u3001\u85e5\u653f\u6e9d\u901a\u3001\u6aa2\u67e5\u53ca\u7533\u5831\u3001\u751f\u7522\u3001\u81e8\u5e8a\u8a66\u9a57\u60a3\u8005\u5165\u7d44\u3001\u53c3\u8207\u53ca\u6578\u64da\u516c\u4f48\u3002\u7531\u65bc\u75ab\u60c5\u6240\u5e36\u4f86\u7684\u9650\u5236\u4ee5\u53ca\u5c0d\u81e8\u5e8a\u3001\u751f\u7522\u548c\u5546\u696d\u904b\u71df\u7684\u6f5b\u5728\u5f71\u97ff\uff0c\u8a72\u6d41\u884c\u75c5\u672a\u4f86\u5c0d\u5168\u7403\u548c\u4e2d\u570b\u7684\u5f71\u97ff\u4ecd\u5b58\u5728\u4e0d\u78ba\u5b9a\u6027\u3002\u6211\u5011\u6b63\u5728\u52aa\u529b\u6e1b\u5c11\u56e0\u75ab\u60c5\u6240\u5c0e\u81f4\u7684\u5de5\u4f5c\u5ef6\u9072\u548c\u4e2d\u65b7\uff0c\u4e26\u5df2\u5236\u5b9a\u76f8\u95dc\u5354\u5b9a\u548c\u6d41\u7a0b\uff0c\u78ba\u4fdd\u516c\u53f8\u7e7c\u7e8c\u6309\u7167\u5728\u5168\u7403\u7bc4\u570d\u5167\u5236\u5b9a\u7684\u5546\u696d\u5316\u3001\u85e5\u653f\u4e8b\u52d9\u3001\u751f\u7522\u53ca\u81e8\u5e8a\u958b\u767c\u76ee\u6a19\u958b\u5c55\u76f8\u95dc\u5de5\u4f5c\u3002<\/p>\n<p>\u8ca1\u52d9\u6458\u8981<\/p>\n<p>\u7c21\u660e\u5408\u4f75\u8cc7\u7522\u8ca0\u50b5\u8868\u6458\u8981\u6578\u64da\uff08\u7f8e\u570b\u4e00\u822c\u516c\u8a8d\u6703\u8a08\u6e96\u5247\uff09<\/p>\n<p>\uff08\u55ae\u4f4d\u70ba\u5343\u7f8e\u5143\uff09<\/p>\n<div>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u622a\u81f3<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">2022\u5e74<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">2021\u5e74\u00a0<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">9\u670830\u65e5<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">12\u670831\u65e5<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\uff08\u672a\u7d93\u5be9\u8a08\uff09<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u8cc7\u7522<\/span><\/p>\n<p>     <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u73fe\u91d1\u3001\u73fe\u91d1\u7b49\u50f9\u7269\u3001\u53d7\u9650\u8cc7\u91d1\u548c\u77ed\u671f\u6295\u8cc7<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">$\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 5,072,510<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">$\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 6,624,849<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u61c9\u6536\u8cec\u6b3e\u6de8\u984d<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">189,170<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">483,113<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u5b58\u8ca8<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">290,911<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">242,626<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u56fa\u5b9a\u8cc7\u7522\u8207\u8a2d\u5099\u6de8\u984d<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">681,914<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">587,605<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u7e3d\u8cc7\u7522<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">6,726,013<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">8,535,525<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u8ca0\u50b5\u548c\u6240\u6709\u8005\u6b0a\u76ca\uff1a<\/span><\/p>\n<p>     <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u61c9\u4ed8\u5e33\u6b3e<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">252,071<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">262,400<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u9810\u63d0\u8cbb\u7528\u53ca\u5176\u4ed6\u61c9\u4ed8\u6b3e\u9805<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">410,255<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">558,055<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u905e\u5ef6\u6536\u5165<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">294,883<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">407,703<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u7814\u767c\u6210\u672c\u5206\u6524\u8ca0\u50b5<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">319,973<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">390,362<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u501f\u6b3e<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">649,333<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">629,678<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u7e3d\u8ca0\u50b5<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">2,070,842<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">2,402,962<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u6240\u6709\u8005\u6b0a\u76ca\u5408\u8a08<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">$\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 4,655,171<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">$\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 6,132,563<\/span><\/p>\n<\/div>\n<p>\u00a0<\/p>\n<p>\u7c21\u660e\u5408\u4f75\u640d\u76ca\u8868\uff08\u7f8e\u570b\u4e00\u822c\u516c\u8a8d\u6703\u8a08\u6e96\u5247\uff09<\/p>\n<p>\uff08\u9664\u666e\u901a\u80a1\u6578\u91cf\u3001ADS\u6578\u91cf\u3001\u6bcf\u80a1\u666e\u901a\u80a1\u548c\u6bcf\u80a1ADS\u6578\u64da\u5916\uff0c\u5176\u9918\u55ae\u4f4d\u5747\u70ba\u5343\u7f8e\u5143\uff09<\/p>\n<div>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u622a\u81f39\u670830\u65e5\u524d\u76843\u500b\u6708<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u622a\u81f39\u670830\u65e5\u524d\u76849\u500b\u6708<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">2022<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">2021 [1]<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">2022 [1]<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">2021 [1]<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\uff08\u672a\u7d93\u5be9\u8a08\uff09<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\uff08\u672a\u7d93\u5be9\u8a08\uff09<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u6536\u5165<\/span><\/p>\n<p>     <\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u7522\u54c1\u6536\u5165\u6de8\u984d<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">$\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 349,506<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">$\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 192,461<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">$\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 915,590<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">$\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 437,202<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5408\u4f5c\u6536\u5165<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">38,122<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">13,979<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">120,236<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">525,102<\/span><\/p>\n<p class=\"prnml20\"><span class=\"prnews_span\">\u7e3d\u6536\u5165<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">387,628<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">206,440<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">1,035,826<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">962,304<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u8cbb\u7528<\/span><\/p>\n<p>     <\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u7522\u54c1\u92b7\u552e\u6210\u672c<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">76,543<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">47,413<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">212,953<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">116,361<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u7814\u767c\u8cbb\u7528<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">426,363<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">351,937<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">1,194,485<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">1,028,754<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u92b7\u552e\u53ca\u7ba1\u7406\u8cbb\u7528<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">322,892<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">269,227<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">948,868<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">683,622<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u7121\u5f62\u8cc7\u7522\u6524\u92b7<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">187<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">188<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">563<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">563<\/span><\/p>\n<p class=\"prnml20\"><span class=\"prnews_span\">\u8cbb\u7528\u7e3d\u8a08<\/span><span class=\"prnews_span\"> <\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">825,985<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">668,765<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">2,356,869<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">1,829,300<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u7d93\u71df\u8667\u640d<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(438,357)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(462,325)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(1,321,043)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(866,996)<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5229\u606f\u6536\u5165\uff08\u652f\u51fa\uff09\uff0c\u6de8\u984d<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">12,759<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(2,230)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">34,261<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(11,275)<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5176\u4ed6\uff08\u8cbb\u7528\uff09\u6536\u5165\uff0c\u6de8\u984d<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(125,640)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">31,477<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(243,290)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">26,487<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u6240\u5f97\u7a05\u524d\u8667\u640d<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(551,238)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(433,078)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(1,530,072)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(851,784)<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u6240\u5f97\u7a05\u8cbb\u7528<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">6,318<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">5,036<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">28,408<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">15,354<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u6de8\u8667\u640d<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(557,556)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(438,114)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(1,558,480)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(867,138)<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u6b78\u5c6c\u767e\u6fdf\u795e\u5dde\u7684\u6bcf\u80a1\u6de8\u8667\u640d\uff1a<\/span><\/p>\n<p>     <\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u57fa\u672c\u548c\u7a00\u91cb<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">$\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 (0.41)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">$\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 (0.36)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">$\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 (1.16)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">$\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 (0.72)<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u6d41\u901a\u80a1\u52a0\u6b0a\u5e73\u5747\u6578\uff1a<\/span><\/p>\n<p>     <\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u57fa\u672c\u548c\u7a00\u91cb<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">1,345,303,747<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">1,205,971,284<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">1,337,976,853<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">1,196,391,201<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u6b78\u5c6c\u767e\u6fdf\u795e\u5dde\u7684\u6bcf\u80a1<\/span><span class=\"prnews_span\">ADS<\/span><span class=\"prnews_span\">\u6de8\u8667\u640d<\/span><\/p>\n<p>     <\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u57fa\u672c\u548c\u7a00\u91cb<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">$\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 (5.39)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">$\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 (4.72)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">$\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 (15.14)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">$\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 (9.42)<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u6d41\u901a<\/span><span class=\"prnews_span\">ADS<\/span><span class=\"prnews_span\">\u52a0\u6b0a\u5e73\u5747\u6578\uff1a<\/span><\/p>\n<p>     <\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u57fa\u672c\u548c\u7a00\u91cb<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">103,484,904<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">92,767,022<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">102,921,296<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">92,030,092<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">[1]\u00a0\u6211\u5011\u4fee\u8a02\u4e86\u90e8\u5206\u4ee5\u524d\u671f\u9593\u8ca1\u52d9\u5831\u8868\u4ee5\u66f4\u6b63\u905e\u5ef6\u6240\u5f97\u7a05\u6de8\u8cc7\u7522\u4f30\u503c\u76f8\u95dc\u7684\u4e00\u9805\u5dee\u932f\uff0c\u8a72\u9805\u5dee\u932f\u5c0d\u5148\u524d\u5df2\u767c\u4f48\u7684<br \/>2022\u5e74\u7b2c\u4e00\u548c\u7b2c\u4e8c\u5b63\u5ea6\uff0c\u4ee5\u53ca2021\u5e74\u5b63\u5ea6\u548c\u5e74\u5ea6\u8ca1\u52d9\u5831\u8868\u4e0d\u91cd\u5927\uff08\u8acb\u53c3\u95b1\u622a\u81f32022\u5e749\u670830\u65e5\u6b6210-Q\u8868\u683c\u5b63<br \/>\u5ea6\u5831\u544a\u4e2d\u7c21\u660e\u5408\u4f75\u8cc7\u7522\u8ca1\u52d9\u5831\u8868\u7684\u76f8\u95dc\u9644\u6ce8\uff0c\u00a0&#8220;\u9644\u6ce81.\u696d\u52d9\u63cf\u8ff0\u3001\u5448\u5217\u57fa\u6e96\u53ca\u5408\u4f75\u539f\u5247\u548c\u91cd\u5927\u6703\u8a08\u653f\u7b56&#8221;\u4ee5\u53ca<br \/>&#8220;\u9644\u6ce82.\u524d\u671f\u8ca1\u52d9\u5831\u8868\u4fee\u8a02&#8221;\uff09\u3002<\/span><\/p>\n<p class=\"prnml10\">\u00a0<\/p>\n<\/div>\n<p>\u00a0<\/p>\n<p>\u95dc\u65bc\u767e\u6fdf\u795e\u5dde<\/p>\n<p>\u767e\u6fdf\u795e\u5dde\u662f\u4e00\u5bb6\u5168\u7403\u6027\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u5c08\u6ce8\u4e8e\u70ba\u5168\u7403\u60a3\u8005\u958b\u767c\u548c\u5546\u696d\u5316\u5275\u65b0\u3001\u53ef\u8ca0\u64d4\u7684\u6297\u816b\u7624\u85e5\u7269\uff0c\u6539\u5584\u60a3\u8005\u7684\u6cbb\u7642\u6548\u679c\uff0c\u63d0\u9ad8\u85e5\u7269\u53ef\u53ca\u6027\u3002\u901a\u904e\u5f37\u5927\u7684\u81ea\u4e3b\u7814\u767c\u80fd\u529b\u548c\u5916\u90e8\u6230\u7565\u5408\u4f5c\uff0c\u6211\u5011\u4e0d\u65b7\u52a0\u901f\u958b\u767c\u591a\u5143\u3001\u5275\u65b0\u7684\u85e5\u7269\u7ba1\u7dda\u3002\u6211\u5011\u81f4\u529b\u65bc\u70ba\u5168\u7403\u66f4\u591a\u60a3\u8005\u5168\u9762\u6539\u5584\u85e5\u7269\u53ef\u53ca\u6027\u3002\u767e\u6fdf\u795e\u5dde\u5728\u5168\u7403\u4e94\u5927\u6d32\u6253\u9020\u4e86\u4e00\u652f\u8d85\u904e9,000\u4eba\u7684\u5718\u968a\uff0c\u4e26\u5728\u4e2d\u570b\u5317\u4eac\u3001\u7f8e\u570b\u9ebb\u7701\u528d\u6a4b\u548c\u745e\u58eb\u5df4\u585e\u723e\u8a2d\u7acb\u4e86\u4e3b\u8981\u8fa6\u4e8b\u8655 \u3002\u6b32\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f<a href=\"http:\/\/www.beigene.com.cn\/\" target=\"_blank\" rel=\"noopener\">http:\/\/www.beigene.com.cn<\/a>\u3002<\/p>\n<p>\u524d\u77bb\u6027\u8072\u660e<\/p>\n<p>\u672c\u65b0\u805e\u7a3f\u5305\u542b\u6839\u64da\u300a1995\u5e74\u79c1\u4eba\u8b49\u5238\u8a34\u8a1f\u6539\u9769\u6cd5\u6848\u300b\uff08Private Securities Litigation Reform Act of 1995\uff09\u4ee5\u53ca\u5176\u4ed6\u806f\u90a6\u8b49\u5238\u6cd5\u5f8b\u4e2d\u5b9a\u7fa9\u7684\u524d\u77bb\u6027\u8072\u660e\uff0c\u5305\u62ec\u6709\u95dc\u65bc\u767e\u6fdf\u795e\u5dde\u5019\u9078\u85e5\u7269\u7684\u81e8\u5e8a\u6578\u64da\u548c\u7372\u6279\u4fe1\u606f\u3001\u5f8c\u671f\u81e8\u5e8a\u8a66\u9a57\u7684\u958b\u5c55\u548c\u9810\u671f\u6578\u64da\u7d50\u679c\u516c\u4f48\uff1b\u5176\u4ed6\u8a08\u5283\u7522\u54c1\u7372\u6279\u548c\u4e0a\u5e02\uff1b\u767e\u6fdf\u795e\u5dde\u5df2\u4e0a\u5e02\u7522\u54c1\u548c\u5019\u9078\u85e5\u7269\u7684\u9810\u671f\u81e8\u5e8a\u958b\u767c\u3001\u85e5\u653f\u6279\u51c6\u3001\u5176\u4ed6\u91cc\u7a0b\u7891\u548c\u5546\u696d\u5316\u9032\u7a0b\uff1b\u8207\u5c0d\u7167\u85e5\u7269\u76f8\u6bd4\u767e\u6085\u6fa4\u00ae\u70baCLL\u60a3\u8005\u63d0\u4f9b\u81e8\u5e8a\u7372\u76ca\u7684\u6f5b\u529b\uff1b\u767e\u6fdf\u795e\u5dde\u7684\u5546\u696d\u5316\u9032\u5c55\u548c\u71df\u6536\u589e\u9577\uff1b\u516c\u53f8\u6b63\u5728\u5efa\u8a2d\u7684\u751f\u7522\u57fa\u5730\u9810\u671f\u7522\u80fd\u548c\u5b8c\u5de5\u6642\u9593\uff1b\u65b0\u51a0\u80ba\u708e\u5168\u7403\u5927\u6d41\u884c\u5c0d\u516c\u53f8\u7684\u81e8\u5e8a\u958b\u767c\u3001\u85e5\u653f\u3001\u5546\u696d\u5316\u3001\u751f\u7522\u4ee5\u53ca\u5176\u4ed6\u696d\u52d9\u5e36\u4f86\u7684\u5f71\u97ff\uff1b\u767e\u6fdf\u795e\u5dde\u8207Ontada\u516c\u53f8\u6230\u7565\u5408\u4f5c\u5b89\u6392\u7684\u9810\u671f\uff1b\u767e\u6fdf\u795e\u5dde\u7684\u8a08\u5283\u548c\u300c\u8fd1\u671f\u696d\u52d9\u4eae\u9ede\u300d\u53ca\u300c\u9810\u671f\u91cc\u7a0b\u7891\u4e8b\u4ef6\u300d\u526f\u6a19\u984c\u4e0b\u7684\u9810\u671f\u4e8b\u4ef6\u548c\u91cc\u7a0b\u7891\uff1b\u4ee5\u53ca\u5728\u300c\u95dc\u65bc\u767e\u6fdf\u795e\u5dde\u300d\u526f\u6a19\u984c\u4e0b\u63d0\u53ca\u7684\u767e\u6fdf\u795e\u5dde\u8a08\u756b\u3001\u627f\u8afe\u3001\u62b1\u8ca0\u548c\u76ee\u6a19\u3002\u7531\u65bc\u5404\u7a2e\u91cd\u8981\u56e0\u7d20\u7684\u5f71\u97ff\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u8207\u524d\u77bb\u6027\u8072\u660e\u6709\u91cd\u5927\u5dee\u7570\u3002\u9019\u4e9b\u56e0\u7d20\u5305\u62ec\uff1a\u767e\u6fdf\u795e\u5dde\u8b49\u660e\u5176\u5019\u9078\u85e5\u7269\u529f\u6548\u548c\u5b89\u5168\u6027\u7684\u80fd\u529b\uff1b\u5019\u9078\u85e5\u7269\u7684\u81e8\u5e8a\u7d50\u679c\u53ef\u80fd\u4e0d\u652f\u6301\u9032\u4e00\u6b65\u958b\u767c\u6216\u4e0a\u5e02\u5be9\u6279\uff1b\u85e5\u653f\u90e8\u9580\u7684\u884c\u52d5\u53ef\u80fd\u6703\u5f71\u97ff\u5230\u81e8\u5e8a\u8a66\u9a57\u7684\u555f\u52d5\u3001\u6642\u9593\u8868\u548c\u9032\u5c55\u4ee5\u53ca\u85e5\u7269\u4e0a\u5e02\u5be9\u6279\uff1b\u767e\u6fdf\u795e\u5dde\u7684\u4e0a\u5e02\u85e5\u7269\u53ca\u5019\u9078\u85e5\u7269\uff08\u5982\u80fd\u7372\u6279\uff09\u7372\u5f97\u5546\u696d\u6210\u529f\u7684\u80fd\u529b\uff1b\u767e\u6fdf\u795e\u5dde\u7372\u5f97\u548c\u7dad\u8b77\u5c0d\u5176\u85e5\u7269\u548c\u6280\u8853\u7684\u77e5\u8b58\u7522\u6b0a\u4fdd\u8b77\u7684\u80fd\u529b\uff1b\u767e\u6fdf\u795e\u5dde\u4f9d\u8cf4\u7b2c\u4e09\u65b9\u9032\u884c\u85e5\u7269\u958b\u767c\u3001\u751f\u7522\u3001\u5546\u696d\u5316\u548c\u5176\u4ed6\u670d\u52d9\u7684\u60c5\u6cc1\uff1b\u767e\u6fdf\u795e\u5dde\u53d6\u5f97\u76e3\u7ba1\u5be9\u6279\u548c\u5546\u696d\u5316\u91ab\u85e5\u7522\u54c1\u7684\u6709\u9650\u7d93\u9a57\uff0c\u53ca\u5176\u7372\u5f97\u9032\u4e00\u6b65\u7684\u71df\u904b\u8cc7\u91d1\u4ee5\u5b8c\u6210\u5019\u9078\u85e5\u7269\u958b\u767c\u4ee5\u53ca\u5be6\u73fe\u4e26\u4fdd\u6301\u76c8\u5229\u7684\u80fd\u529b\uff1b\u65b0\u51a0\u80ba\u708e\u5168\u7403\u5927\u6d41\u884c\u5c0d\u767e\u6fdf\u795e\u5dde\u7684\u81e8\u5e8a\u958b\u767c\u3001\u76e3\u7ba1\u3001\u5546\u696d\u5316\u904b\u71df\u3001\u751f\u7522\u4ee5\u53ca\u5176\u4ed6\u696d\u52d9\u5e36\u4f86\u7684\u5f71\u97ff\uff1b\u767e\u6fdf\u795e\u5dde\u5728\u6700\u8fd1\u5b63\u5ea6\u5831\u544a\u7684\u00a010-Q\u8868\u683c\u4e2d\u300c\u98a8\u96aa\u56e0\u7d20\u300d\u7ae0\u7bc0\u88e1\u66f4\u5168\u9762\u8a0e\u8ad6\u7684\u5404\u985e\u98a8\u96aa\uff1b\u4ee5\u53ca\u767e\u6fdf\u795e\u5dde\u5411\u7f8e\u570b\u8b49\u5238\u4ea4\u6613\u59d4\u54e1\u6703\u671f\u5f8c\u5448\u5831\u4e2d\u95dc\u65bc\u6f5b\u5728\u98a8\u96aa\u3001\u4e0d\u78ba\u5b9a\u6027\u4ee5\u53ca\u5176\u4ed6\u91cd\u8981\u56e0\u7d20\u7684\u8a0e\u8ad6\u3002\u672c\u65b0\u805e\u7a3f\u4e2d\u7684\u6240\u6709\u4fe1\u606f\u50c5\u53ca\u65bc\u65b0\u805e\u7a3f\u767c\u4f48\u4e4b\u65e5\uff0c\u9664\u975e\u6cd5\u5f8b\u8981\u6c42\uff0c\u767e\u6fdf\u795e\u5dde\u4e26\u7121\u8cac\u4efb\u66f4\u65b0\u8a72\u7b49\u4fe1\u606f\u3002<\/p>\n<p>\u500d\u5229\u59a5\u00ae\u548c\u51f1\u6d1b\u65af\u00ae\u70ba\u5b89\u9032\u516c\u53f8\u7684\u6ce8\u518a\u5546\u6a19\u3002<br 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Oyler\uff09\u5148\u751f\u8868\u793a\uff1a\u300c\u767e\u6fdf\u795e\u5dde\u7b2c\u4e09\u5b63\u5ea6\u7522\u54c1\u6536\u5165\u53d6\u5f97\u5f37\u52c1\u589e\u9577\uff0c\u4e3b\u8981\u5f97\u76ca\u4e8e\u6211\u5011\u81ea\u4e3b\u7814\u767c\u7684\u57fa\u77f3\u7522\u54c1\u767e\u6085\u6fa4\u00ae\u548c\u767e\u6fa4\u5b89\u00ae\u92b7\u552e\u984d\u7684\u63d0\u5347\u3002\u767e\u6085\u6fa4\u00ae\u5df2\u5728\u5168\u7403\u8d85\u904e55\u500b\u5e02\u5834\u7372\u6279\u3002\u6211\u5011\u975e\u5e38\u6b23\u559c\u5730\u770b\u5230\uff0c\u5728\u8fd1\u671f\u516c\u4f48\u7684\u6578\u64da\u4e2d\uff0c\u767e\u6085\u6fa4\u00ae\u5c0d\u6bd4\u5104\u73c2\u00ae\u5728\u7121\u9032\u5c55\u751f\u5b58\u671f\u7d42\u671f\u5206\u6790\u4e2d\u53d6\u5f97\u4e86\u512a\u6548\u6027\u7d50\u679c\u3002\u9019\u4e5f\u518d\u6b21\u8b49\u660e\u767e\u6085\u6fa4\u00ae\u6709\u6f5b\u529b\u6210\u70ba\u4e00\u9805\u70ba\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08CLL\uff09\u60a3\u8005\u53ca\u5176\u5bb6\u5ead\u5e36\u4f86\u5e0c\u671b\u7684\u5168\u65b0\u6cbb\u7642\u65b9\u6848\u3002\u6211\u5011\u671f\u5f85\u8207\u91ab\u5b78\u754c\u548c\u60a3\u8005\u7fa4\u9ad4\u5206\u4eab\u9019\u4e00\u8a66\u9a57\u7684\u8a73\u76e1\u7814\u7a76\u7d50\u679c\uff0c\u671f\u5f85\u5728\u672a\u4f86\u5e7e\u500b\u6708\u4e2d\u4e0d\u65b7\u5e36\u4f86\u91cd\u8981\u91cc\u7a0b\u7891\u9032\u5c55\uff0c\u4e5f\u671f\u5f85\u7e7c\u7e8c\u4fdd\u6301\u5f37\u52c1\u589e\u9577\u52e2\u982d\uff0c\u70ba2022\u5e74\u756b\u4e0a\u5713\u6eff\u7684\u53e5\u865f\u3002\u300d 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