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\u7372\u5f97\u591a\u500b\u81e8\u5e8a\u6307\u5357\u63a8\u85a6\uff1a\u5171\u67096\u500b\u6cbb\u7642\u65b9\u6848\u7372\u5f975\u500b\u570b\u969b\u77e5\u540d\u91ab\u5b78\u7d44\u7e54\u7684<span>18\u9805\u91cd\u8981\u6216<\/span>\u63d0\u53ca\u63a8\u85a6\uff0c\u5305\u62ec\u7f8e\u570b\u570b\u5bb6\u7d9c\u5408\u764c\u75c7\u7db2\u7d61\uff08NCCN\uff09\u6307\u5357\u3001\u4e2d\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08CSCO\uff09\u6307\u5357\u3001\u6b50\u6d32\u816b\u7624\u5167\u79d1\u5b78\u6703\uff08ESMO\uff09\u6307\u5357\u3001\u570b\u969b\u9aa8\u9ad3\u7624\u5de5\u4f5c\u7d44\uff08IMWG\uff09\u6307\u5357\u548c2022\u7248\u300a\u4e2d\u570b\u591a\u767c\u6027\u9aa8\u9ad3\u7624\u8a3a\u6cbb\u6307\u5357\u300b\u3002   8\u9805\u5e0c\u7dad\u5967\u00ae\u7684\u81e8\u5e8a\u8a66\u9a57\u6b63\u5728\u63a8\u9032\uff0c4\u9805\u8a66\u9a57\u70ba\u6ce8\u518a\u6027\u7814\u7a76\uff0c\u5176\u4e2d2\u9805\u5168\u7403\u8a66\u9a57\u7531\u5fb7\u742a\u91ab\u85e5\u8207Karyopharm\u516c\u53f8\u806f\u624b\u958b\u5c55\u3002   MARCH\u7814\u7a76\u7684\u95dc\u9375\u6027\u7814\u7a76\u6578\u64da\u5df2\u5728\u6b50\u6d32\u8840\u6db2\u5b78\u5354\u6703\uff08EHA\uff09\u5e74\u6703\u4e0a\u516c\u5e03\uff0c\u4e26\u7372\u5f97\u300aBMC\u91ab\u5b78\u300b\u96dc\u5fd7\u767c\u8868\u3002   \u4e00\u652f\u8fd1190\u4eba\u4e26\u5728\u4e2d\u570b\u548c\u4e9e\u592a\u5340\u64c1\u6709\u8c50\u5bcc\u7d93\u9a57\u7684\u5546\u696d\u5316\u5718\u968a\u70ba\u5e0c\u7dad\u5967\u00ae\u7684\u6210\u529f\u4e0a\u5e02\u5960\u5b9a\u4e86\u5805\u5be6\u7684\u57fa\u790e\u3002\u6b64\u5916\uff0c\u516c\u53f8\u5c0d\u65bc\u76ee\u6a19\u5e02\u5834\u7684\u7576\u5730\u60c5\u6cc1\u548c\u95dc\u9375\u5229\u76ca\u76f8\u95dc\u8005\uff08\u81e8\u5e8a\u5c08\u5bb6\u3001\u91ab\u751f\u53ca\u4e3b\u8981\u884c\u696d\u6a5f\u69cb\uff09\u64c1\u6709\u6df1\u5165\u7684\u4e86\u89e3\u3002  <\/p>\n<p>\u8655\u65bc\u4e2d\u665a\u671f\u958b\u767c\u968e\u6bb5\u7684\u7522\u54c1\uff08\u5fb7\u742a\u91ab\u85e5\u64c1\u6709\u90e8\u5206\u4e9e\u592a\u6b0a\u76ca\uff09<\/p>\n<p>\u516c\u53f8\u6b63\u5728\u8a55\u4f30\u5169\u6b3e\u65b0\u578bXPO1\u6291\u5236\u5291\u4ee5\u53ca\u4e00\u6b3e\u65b0\u578bmTORC 1\/2\u96d9\u91cd\u6291\u5236\u5291\u3002<\/p>\n<p>&#8211;\u00a0\u00a0\u00a0\u00a0\u00a0 \u585e\u5229\u5c3c\u7d22\uff08ATG-010\uff0c\u540c\u985e\u9996\u6b3eXPO1\u6291\u5236\u5291\uff09\uff1a\u6211\u5011\u5c07\u7e7c\u7e8c\u5927\u529b\u63a8\u9032\u5c0d\u65bc\u5e0c\u7dad\u5967\u00ae\u7684\u958b\u767c\uff0c\u901a\u904e\u591a\u9805\u91dd\u5c0dMM\u548c\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08NHL\uff09\u4ee5\u53ca\u591a\u500b\u65b0\u578b\u806f\u5408\u7642\u6cd5\u7684\u7814\u7a76\uff0c\u4ee5\u64f4\u5c55\u8a72\u7522\u54c1\u7684\u9069\u61c9\u75c7\u548c\u5e02\u5834\u5360\u6709\u7387\u3002\u76ee\u524d\u8a55\u4f30\u5e0c\u7dad\u5967\u00ae\u55ae\u85e5\u53ca\u806f\u5408\u73fe\u6709\u65b9\u6848\u7528\u65bc\u6cbb\u7642MM\u3001DLBCL\u4ee5\u53ca\u5176\u5b83\u8840\u6db2\u816b\u7624\u7684\u81e8\u5e8a\u8a66\u9a57\u6b63\u5728\u9032\u884c\u4e2d\u3002\u9019\u4e9b\u7814\u7a76\u6709\u671b\u6539\u5584\u60a3\u8005\u7684\u7de9\u89e3\u7387\u4e26\u64f4\u5c55\u8a72\u85e5\u7269\u7684\u81e8\u5e8a\u6f5b\u529b\u3002<\/p>\n<p>2022\u5e745\u6708\uff0c\u65e8\u5728\u8a55\u4f30\u585e\u5229\u5c3c\u7d22\u806f\u5408\u4f86\u90a3\u5ea6\u80fa\u548c\u5229\u59a5\u6614\u55ae\u6297\uff08SR2\u65b9\u6848\uff09\u7528\u65bc\u6cbb\u7642R\/R DLBCL\u548c\u5fa9\u767c\/\u96e3\u6cbb\u6027\u60f0\u6027\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08R\/R iNHL\uff09\u7684I\/II\u671fSWATCH\u7814\u7a76\u5b8c\u6210\u9996\u4f8b\u4e2d\u570b\u60a3\u8005\u7d66\u85e5\u3002   \u585e\u5229\u5c3c\u7d22\u7528\u65bc\u6cbb\u7642R\/R MM\u7684\u95dc\u9375\u6027\u6a4b\u63a5\u7814\u7a76\uff08MARCH\u7814\u7a76\uff09\u6578\u64da\u57282022 EHA\u4e0a\u516c\u5e03\uff0c\u4e26\u7372\u5f97\u300aBMC\u91ab\u5b78\u300b\u96dc\u5fd7\u767c\u8868\u3002  <\/p>\n<p>&#8211;\u00a0\u00a0\u00a0\u00a0\u00a0 Eltanexor (ATG-016, \u7b2c\u4e8c\u4ee3XPO1\u6291\u5236\u5291)<\/p>\n<p>\u7528\u65bc\u6cbb\u7642\u5be6\u9ad4\u7624\u548c\u8840\u6db2\u816b\u7624\u7684KCP-8602\u7814\u7a76\u7684II\u671f\u8a66\u9a57\u6b63\u5728\u4e2d\u570b\u5165\u7d44\u9ad8\u5371\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\uff08MDS\uff09\u60a3\u8005  <\/p>\n<p>&#8211;\u00a0\u00a0\u00a0\u00a0\u00a0 Onatasertib\uff08ATG-008\uff0cmTORC1\/2\u6291\u5236\u5291\uff09<\/p>\n<p>ATG-008\u806f\u5408\u7279\u745e\u666e\u5229\u55ae\u6297\uff08\u6297PD-1\u6297\u9ad4\u85e5\u7269\uff09\u7528\u65bc\u6cbb\u7642\u5be6\u9ad4\u7624\u7684I\/II\u671fTORCH-2\u7814\u7a76\u6578\u64da\u57282022\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\u4e0a\u516c\u5e03\u3002  <\/p>\n<p>\u8655\u65bc\u65e9\u671f\u81e8\u5e8a\u958b\u767c\u968e\u6bb5\u7684\u7522\u54c1\uff08\u5fb7\u742a\u91ab\u85e5\u64c1\u6709\u5168\u7403\u6b0a\u76ca\uff09<\/p>\n<p>\u9ad8\u5dee\u7570\u5316\u7684\u7279\u6027\u8b93\u5fb7\u742a\u91ab\u85e5\u7684\u65e9\u671f\u81e8\u5e8a\u8cc7\u7522\u5728\u76f8\u95dc\u9818\u57df\u4e2d\u66f4\u5177\u7af6\u722d\u529b<\/p>\n<p>ATG-017\uff08ERK1\/2\u6291\u5236\u5291\uff09\u8207\u6aa2\u67e5\u9ede\u6291\u5236\u5291\u548cKRAS\u6291\u5236\u5291\u5177\u6709\u6f5b\u5728\u7684\u5354\u540c\u6548\u61c9\u3002ATG-017\u7528\u65bc\u6cbb\u7642\u665a\u671f\u5be6\u9ad4\u7624\u548c\u8840\u6db2\u816b\u7624\u60a3\u8005\u7684I\u671fERASER\u7814\u7a76\u6b63\u5728\u6fb3\u5927\u5229\u4e9e\u9032\u884c\u3002\u5fb7\u742a\u91ab\u85e5\u6b63\u8207\u767e\u6642\u7f8e\u65bd\u8cb4\u5bf6\u516c\u53f8\uff08BMS\uff09\u5c55\u958b\u81e8\u5e8a\u5408\u4f5c\uff0c\u5171\u540c\u8a55\u4f30ATG-017\u806f\u5408\u6b50\u72c4\u6c83\u00ae\uff08\u7d0d\u6b66\u5229\u5c24\u55ae\u6297\uff09\u5728\u665a\u671f\u5be6\u9ad4\u7624\u60a3\u8005\u4e2d\u7684\u6cbb\u7642\u6f5b\u529b\u3002<br \/>\nATG-101\uff08PD-L1\/4-1BB\u96d9\u7279\u7570\u6297\u9ad4\uff09\u53ef\u963b\u6b62\u5177\u6709\u514d\u75ab\u6291\u5236\u6548\u61c9\u7684PD-1\/PD-L1D\u7684\u7d50\u5408\u4e26\u6fc0\u6d3b\u514d\u75ab\u56e0\u5b50\u3002ATG-101\u7528\u65bc\u6cbb\u7642\u8f49\u79fb\u6027\/\u665a\u671f\u5be6\u9ad4\u7624\u548cB\u7d30\u80de\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08B-NHL\uff09\u60a3\u8005\u7684I\u671fPROBE\u7814\u7a76\u6b63\u5728\u7f8e\u570b\u3001\u6fb3\u5927\u5229\u4e9e\u548c\u4e2d\u570b\u9032\u884c\u3002<br \/>\nATG-037\uff08CD73\u5c0f\u5206\u5b50\u6291\u5236\u5291\uff09\u53ef\u964d\u4f4e\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u7684\u514d\u75ab\u6291\u5236\u3002ATG-037\u7528\u65bc\u6cbb\u7642\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u5be6\u9ad4\u7624\u60a3\u8005\u7684I\u671fSTAMINA\u7814\u7a76\u6b63\u5728\u6fb3\u5927\u5229\u4e9e\u958b\u5c55\u60a3\u8005\u5165\u7d44\u3002<br \/>\nATG-018\uff08ATR\u5c0f\u5206\u5b50\u6291\u5236\u5291\uff09\u53ef\u9650\u5236\u816b\u7624\u7d30\u80de\u4e2d\u7684DNA\u640d\u50b7\u4fee\u5fa9\u6a5f\u5236\u3002\u91dd\u5c0d\u6cbb\u7642\u665a\u671f\u5be6\u9ad4\u7624\u548c\u8840\u6db2\u816b\u7624\u60a3\u8005\u7684I\u671fATRIUM\u7814\u7a76\u5df2\u5728\u6fb3\u5927\u5229\u4e9e\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u7d66\u85e5\u3002  <\/p>\n<p>\u81ea\u4e3b\u7814\u767c\u9805\u76ee\u9032\u5c55<\/p>\n<p>\u9810\u8a08\u57282022\u5e74\u9032\u5165\u81e8\u5e8a\u968e\u6bb5\u7684\u5019\u9078\u7522\u54c1\uff1a\u00a0ATG-022\uff08Claudin 18.2\u6297\u9ad4\u5076\u806f\u85e5\u7269\uff09\uff0c\u9810\u8a08\u5c07\u65bc2022\u5e74\u4e0b\u534a\u5e74\u63d0\u4ea4IND\u3002<br \/>\n\u6709\u671b\u57282023\u5e74\u63d0\u4ea4IND\u7684\u7522\u54c1\uff1aATG-031\uff08\u6297CD24\u6297\u9ad4\uff09<br \/>\n\u8655\u65bc\u65e9\u671f\u7814\u767c\u548cIND\u9810\u5099\u968e\u6bb5\u7684\u7522\u54c1\uff1aATG-027 (B7H3\/PD-L1 \u96d9\u7279\u7570\u6297\u9ad4), ATG-032\uff08LILRB\u6297\u9ad4\uff09\u548cATG-041\uff08Axl-Mer\u6291\u5236\u5291\uff09  <\/p>\n<p>\u5546\u696d\u62d3\u5c55<\/p>\n<p>\u5fb7\u742a\u91ab\u85e5\u5074\u91cd\u65bc\u81e8\u5e8a\u958b\u767c\u65b9\u9762\u7684\u5408\u4f5c\uff0c\u5275\u65b0\u8cc7\u7522\u7684\u5f15\u9032\u4ee5\u53ca\u5229\u7528\u65b0\u578b\u6280\u8853\u5e73\u53f0\u548c\u85e5\u7269\u958b\u767c\u6280\u8853\u5c0d\u516c\u53f8\u81ea\u6709\u7684\u7814\u767c\u80fd\u529b\u9032\u884c\u88dc\u5145\u548c\u5f37\u5316\u3002<\/p>\n<p>\u8207\u767e\u6fdf\u795e\u5dde\u9054\u6210\u81e8\u5e8a\u958b\u767c\u5408\u4f5c\uff0c\u5c07\u806f\u624b\u958b\u5c55\u65e8\u5728\u8a55\u4f30\u5e0c\u7dad\u5967\u00ae\u806f\u5408\u767e\u6fa4\u5b89\u00ae\u7528\u65bc\u6cbb\u7642T\u548cNK\u7d30\u80de\u6dcb\u5df4\u7624\u60a3\u8005\u7684I\/II\u7814\u7a76\u3002   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