{"id":8238,"date":"2022-08-25T11:43:00","date_gmt":"2022-08-25T03:43:00","guid":{"rendered":"https:\/\/www.franchise.com.hk\/%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%85%ac%e4%bd%882022%e5%b9%b4%e4%b8%ad%e6%9c%9f%e6%a5%ad%e7%b8%be%e5%8f%8a%e5%85%ac%e5%8f%b8%e9%80%b2%e5%b1%95\/8238"},"modified":"2022-08-25T11:43:00","modified_gmt":"2022-08-25T03:43:00","slug":"%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%85%ac%e4%bd%882022%e5%b9%b4%e4%b8%ad%e6%9c%9f%e6%a5%ad%e7%b8%be%e5%8f%8a%e5%85%ac%e5%8f%b8%e9%80%b2%e5%b1%95","status":"publish","type":"post","link":"https:\/\/www.franchise.com.hk\/en\/%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%85%ac%e4%bd%882022%e5%b9%b4%e4%b8%ad%e6%9c%9f%e6%a5%ad%e7%b8%be%e5%8f%8a%e5%85%ac%e5%8f%b8%e9%80%b2%e5%b1%95\/8238","title":{"rendered":"\u4fe1\u9054\u751f\u7269\u516c\u4f482022\u5e74\u4e2d\u671f\u696d\u7e3e\u53ca\u516c\u53f8\u9032\u5c55"},"content":{"rendered":"

\u7387\u5148\u6253\u9020\u5275\u65b0\u85e5\u4f01\u53ef\u6301\u7e8c\u767c\u5c55\u6a21\u5f0f\uff0c<\/p>\n

\u5546\u696d\u5316\u7ba1\u7406\u5347\u7d1a2.0\u6a21\u5f0f\uff0c34\u689d\u96c4\u539a\u7522\u54c1\u7ba1\u7dda\u539a\u7a4d\u8584\u767c<\/p>\n

\u7f8e\u570b\u7f85\u514b\u7dad\u723e\u548c\u4e2d\u570b\u8607\u5dde<\/span>2022\u5e748\u670825\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u80a1\u7968\u4ee3\u78bc\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u514d\u3001\u4ee3\u8b1d\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u5275\u65b0\u85e5\u7269\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u516c\u4f48\u4e862022\u5e74\u5ea6\u4e2d\u671f\u696d\u7e3e\u548c\u516c\u53f8\u9032\u5c55\u3002<\/p>\n

\u4fe1\u9054\u751f\u7269\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u9577\u517cCEO\u4fde\u5fb7\u8d85\u535a\u58eb\u8868\u793a\uff1a\u300c2022\u5e74\u662f\u4fe1\u9054\u65b0\u5341\u5e74\u7684\u958b\u7aef\uff0c\u516c\u53f8\u5df2\u5efa\u7acb\u8d77\u6210\u719f\u7684\u5e73\u53f0\u57fa\u790e\u3001\u6301\u7e8c\u5f37\u5927\u7684\u57f7\u884c\u529b\u53ca\u5065\u5eb7\u7684\u8ca1\u52d9\u72c0\u6cc1\u30022022\u5e74\u81f3\u4eca\uff0c\u4fe1\u9054\u5805\u6301\u8d70\u5168\u7403\u5316\u5275\u65b0\u7684\u9577\u671f\u767c\u5c55\u6230\u7565\uff0c\u6301\u7e8c\u5728\u5546\u696d\u5316\u3001\u7522\u54c1\u958b\u767c\u3001\u751f\u7522\u548c\u696d\u52d9\u5408\u4f5c\u7b49\u5404\u65b9\u9762\u4e0d\u65b7\u53d6\u5f97\u986f\u8457\u6210\u7e3e\u3002\u8207\u6b64\u540c\u6642\uff0c\u4f5c\u70ba\u4e2d\u570b\u521d\u5275\u578b\u5275\u65b0\u751f\u7269\u88fd\u85e5\u4f01\u696d\u7684\u4e00\u54e1\uff0c\u516c\u53f8\u9818\u5148\u4f48\u5c40\u548c\u512a\u5316\u7d44\u7e54\u7d50\u69cb\uff0c\u63d0\u5347\u696d\u52d9\u7cbe\u76ca\u5316\u7ba1\u7406\u80fd\u529b\uff0c\u4e0d\u65b7\u63a2\u7d22\u548c\u767c\u5c55\u521d\u5275\u578b\u5275\u65b0\u751f\u7269\u85e5\u516c\u53f8\u66f4\u52a0\u53ef\u6301\u7e8c\u7684\u696d\u52d9\u767c\u5c55\u6a21\u5f0f\uff0c\u66f4\u9ad8\u6548\u5730\u652f\u6490\u548c\u843d\u5730\u9577\u671f\u6230\u7565\u3002\u6211\u5011\u5c07\u7e7c\u7e8c\u63d0\u5347\u85e5\u7269\u7814\u767c\u80fd\u529b\u3001\u58ef\u5927\u5168\u7403\u7814\u767c\u5718\u968a\u3001\u63a8\u52d5\u5168\u7403\u5275\u65b0\u958b\u767c\uff0c\u540c\u6642\u64f4\u5927\u5546\u696d\u5316\u7522\u54c1\u7d44\u5408\u53ca\u63d0\u5347\u6548\u76ca\u8868\u73fe\uff0c\u70ba\u60a3\u8005\u3001\u54e1\u5de5\u3001\u80a1\u6771\u548c\u793e\u6703\u4e0d\u65b7\u5275\u9020\u50f9\u503c\uff0c\u5be6\u73fe\u516c\u53f8\u7684\u9577\u671f\u53ef\u6301\u7e8c\u5065\u5eb7\u767c\u5c55\u3002\u300d<\/p>\n

\u696d\u7e3e\u4eae\u9ede \u4e00\u7779\u70ba\u5148<\/p>\n

\u7e3d\u6536\u516522.40\u5104\uff0c\u7522\u54c1\u6536\u516520.41\u5104\u4eba\u6c11\u5e63\uff0c\u7522\u54c1\u6536\u5165\u540c\u6bd4\u589e\u957710.0%<\/p>\n

\u5546\u696d\u5316\u7248\u5716\u64f4\u5145\u81f3\u4e03\u500b\u4e0a\u5e02\u7522\u54c1\uff1b\u5df2\u4e0a\u5e02\u7522\u54c1\u5728\u66f4\u591a\u5730\u5340\u548c\u66f4\u591a\u9069\u61c9\u75c7\u4e0a\u7372\u6279 \u9054\u4f2f\u8212\u00ae<\/span> \u5e74\u521d\u65b0\u589e\u4e09\u9805\u9ad8\u767c\u7624\u7a2e\u4e00\u7dda\u9069\u61c9\u75c7\u7d0d\u5165\u570b\u5bb6\u91ab\u4fdd\u76ee\u9304\uff1b\u5e74\u4e2d\u65b0\u589e\u4e00\u7dda\u98df\u7ba1\u764c\u548c\u4e00\u7dda\u80c3\u764c\u5169\u5927\u9069\u61c9\u75c7\u7372\u6279 <\/p>\n

\u5546\u696d\u5316\u7ba1\u7406\u6a21\u5f0f\u5347\u7d1a2.0\uff0c\u9818\u5148\u4f48\u5c40\u548c\u512a\u5316\u7d44\u7e54\u7d50\u69cb\uff0c\u63d0\u5347\u696d\u52d9\u7cbe\u76ca\u5316\u7ba1\u7406\u80fd\u529b\uff0c\u9032\u4e00\u6b65\u63d0\u9ad8\u7522\u51fa\u3001\u63d0\u5347\u6548\u76ca
\n\u767c\u63ee\u5e73\u53f0\u50f9\u503c\u53ca\u7368\u7279\u7af6\u722d\u512a\u52e2\uff0c\u8207\u570b\u969b\u77e5\u540d\u85e5\u4f01\u79ae\u4f86\u3001\u8cfd\u8afe\u83f2\u9054\u6210\u6df1\u5ea6\u6230\u7565\u5408\u4f5c\uff0c\u52a0\u901f\u5275\u65b0 \u5805\u6301\u5168\u7403\u5275\u65b0\u4f48\u5c40\uff0c\u5275\u65b0\u7ba1\u7dda\u8b80\u51fa\u66f4\u591a\u6578\u64da
\n\u4e03\u500b\u5206\u5b50\u8655\u65bcNDA\u6216\u81e8\u5e8a\u7814\u7a76\u5f8c\u671f \u816b\u7624\u7ba1\u7dda\u591a\u500b\u5168\u7403\u5275\u65b0\u5206\u5b50\u8b80\u51fa\u521d\u6b65\u7a4d\u6975\u7684\u81e8\u5e8a\u7814\u7a76\u6578\u64da \u975e\u816b\u7624\u7ba1\u7dda\u4eae\u773c\u4e8c\u671f\u6578\u64da\u983b\u51fa\uff0c\u65b0\u589e\u5169\u500b\u5206\u5b50\u5373\u5c07\u9032\u5165\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76 <\/p>\n

\u7522\u54c1\u5feb\u901f\u653e\u91cf \u5546\u696d\u5316\u7ba1\u7406\u6a21\u5f0f\u5347\u7d1a2.0 <\/p>\n

\u7372\u6279\u54c1\u7a2e\u589e\u52a0\u81f3\u4e03\u6b3e\uff1a\u9054\u4f2f\u8212\u00ae\u3001\u9054\u6538\u540c\u00ae\u3001\u8607\u7acb\u4fe1\u00ae\u3001\u9054\u4f2f\u83ef\u00ae\u3001\u9054\u4f2f\u5766\u00ae\u3001\u8010\u7acb\u514b\u00ae\u3001\u5e0c\u5189\u64c7\u00ae
\n \u7522\u54c1\u6536\u516520.41\u5104\u4eba\u6c11\u5e63\uff0c\u540c\u6bd4\u589e\u957710.0%\uff0c\u7522\u54c1\u4fdd\u6301\u5feb\u901f\u653e\u91cf,\u5354\u540c\u50f9\u503c\u91cb\u653e \u5ee3\u95ca\u7684\u6e20\u9053\u8986\u84cb\u548c\u5c08\u696d\u7684\u5546\u696d\u5316\u5718\u968a\u57fa\u790e\uff1a\u8d855000\u5bb6\u91ab\u9662\u8986\u84cb\uff0c\u8fd13000\u4eba\u5546\u696d\u5316\u5718\u968a \u5546\u696d\u5316\u7ba1\u7406\u518d\u5347\u7d1a\uff0c\u555f\u75282.0\u6a21\u5f0f\uff1a
\n\u696d\u52d9\u67b6\u69cb\u8abf\u6574\u5347\u7d1a\uff0c\u6253\u9020\u5c08\u696dBU\u6a21\u5f0f\uff0c\u9ad8\u6548\u7cbe\u6e96\u71df\u92b7\u9ad4\u7cfb \u7e7c\u7e8c\u63d0\u5347\u92b7\u552e\u7522\u51fa\uff0c\u517c\u9867\u63d0\u9ad8\u6548\u76ca\uff0c\u652f\u6301\u696d\u52d9\u9577\u671f\u53ef\u6301\u7e8c\u5065\u5eb7\u767c\u5c55 <\/p>\n

34\u500b\u96c4\u539a\u7684\u7814\u767c\u7ba1\u7dda \u9ad8\u6f5b\u5206\u5b50\u9010\u6b65\u8b80\u51fa\u6578\u64da<\/p>\n

7\u500b\u7522\u54c1\u7372\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c3\u500b\u54c1\u7a2e\u5728NMPA\u5be9\u8a55\u4e2d\uff0c4\u500b\u54c1\u7a2e\u9032\u5165III\u671f\u6216\u95dc\u9375\u6027\u81e8\u5e8a\u7814\u7a76\uff0c\u53e6\u670920\u500b\u7522\u54c1\u5df2\u9032\u5165\u81e8\u5e8a\u7814\u7a76\u3002<\/p>\n

\u816b\u7624\uff1a25\u500b\u96c4\u539a\u7684\u7814\u767c\u7ba1\u7dda\uff0c\u5168\u9762\u8986\u84cb\u4e3b\u8981\u816b\u7624\u9818\u57df<\/p>\n

PD-1\u9818\u5148\u54c1\u724c\u9054\u4f2f\u8212\u00ae\uff1a
\n\u65b0\u589e\u4e09\u9805\u9ad8\u767c\u7624\u7a2e\u4e00\u7dda\u9069\u61c9\u75c7\u7d0d\u5165\u570b\u5bb6\u91ab\u4fdd\u76ee\u9304\uff08\u975e\u9c57\u72c0\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u3001\u9c57\u72c0\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u3001\u809d\u764c\uff09 \u65b0\u589e\u4e00\u7dda\u98df\u7ba1\u764c\u548c\u4e00\u7dda\u80c3\u764c\u5169\u5927\u9069\u61c9\u75c7\u7372\u6279 <\/p>\n

\u5169\u9805NDA\uff0c\u591a\u500b\u8a3b\u518a\/\u95dc\u9375\u81e8\u5e8a\u7814\u7a76\uff1a<\/p>\n

Retsevmo\u00ae\uff08\u585e\u666e\u66ff\u5c3c\uff09\uff0c\u5df2\u905e\u4ea4NDA IBI-326 (BCMA CAR-T) \uff0c\u5df2\u905e\u4ea4NDA IBI-310 (CTLA-4) IBI-344 (ROS1\/NTRK) IBI-376 (PI3K\u03b4) IBI-126 (CEACAM5 ADC)
\n\u767c\u4f48\u591a\u500b\u5168\u7403\u5275\u65b0\u5206\u5b50\u521d\u6b65\u7a4d\u6975\u81e8\u5e8a\u7814\u7a76\u6578\u64da\uff1a
\nIBI-110 (LAG3)\uff1a \u4e00\u7dda\u80ba\u9c57\u764c\uff0c\u4e00\u7dda\u80c3\u764c IBI-188 (CD47): \u4e00\u7dda\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81 IBI-351 (KRASG12C): \u80ba\u764c\uff0c\u7d50\u76f4\u8178\u764c IBI-344 (ROS1\/NTRK) :\u80ba\u764c <\/p>\n

\u975e\u816b\u7624\uff1a9\u6b3e\u9ad8\u5ea6\u5dee\u7570\u5316\u5206\u5b50\u5e36\u4f86\u539a\u7a4d\u8584\u767c\u7684\u589e\u9577\u7a7a\u9593<\/p>\n

\u4e00\u9805NDA\uff0c\u5546\u696d\u5316\u6709\u671b\u518d\u6dfb\u65b0\u6210\u54e1<\/p>\n

IBI-306 (PCSK9) \uff0c\u5df2\u905e\u4ea4NDA
\n\u4eae\u773c\u4e8c\u671f\u6578\u64da\u983b\u51fa\uff0c\u65b0\u589e\u5169\u500b\u5206\u5b50\u5373\u5c07\u9032\u5165\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76
\nIBI-362 (GLP-1\/GCGR) \uff1a\u6e1b\u91cd\u548c\u7cd6\u5c3f\u75c5\u4e8c\u671f\u7d50\u679c\u8b80\u51fa\uff1a\u5f37\u52c1\u7684\u6e1b\u91cd\u548c\u964d\u7cd6\u6548\u679c\u53ca\u4e00\u7cfb\u5217\u65b0\u9673\u4ee3\u8b1d\u7372\u76ca\u30022022\u5e74\u5e95\u81f32023\u5e74\u521d\u9032\u5165\u6e1b\u91cd\u53ca\u7cd6\u5c3f\u75c5\u96d9\u9805\u9069\u61c9\u75c7III\u671f\u81e8\u5e8a\u7814\u7a76\u3002 IBI-112 (IL-23p19)\uff1a\u9280\u5c51\u75c5\u4e8c\u671f\u7d50\u679c\u8b80\u51fa\uff1a\u6f5b\u5728\u7684\u9577\u671f\u7642\u6548\u512a\u52e2\u548c\u5ef6\u9577\u7d66\u85e5\u9593\u9694\u7684\u4fbf\u5229\u6027\u30022022\u5e74\u4e0b\u534a\u5e74\u9032\u5165\u9280\u5c51\u75c5III\u671f\u81e8\u5e8a\u7814\u7a76\u3002 <\/p>\n

\u6301\u7e8c\u63a8\u9032\u5168\u7403\u5275\u65b0\u7684\u6838\u5fc3\u767c\u5c55\u6230\u7565<\/p>\n

\u7f8e\u570b\u7814\u767c\u4e2d\u5fc3\u53ca\u6d77\u5916\u958b\u767c\u8a3b\u518a\u5718\u968a\u5efa\u8a2d\uff1a
\n\u7f8e\u570b\u7814\u767c\u4e2d\u5fc3\u5168\u65b9\u4f4d\u6295\u5165\u904b\u71df\uff0c\u570b\u6e05\u9662\u4e2d\u7f8e\u5718\u968a\u4e09\u767e\u4f4d\u79d1\u5b78\u5bb6\u5354\u4f5c\u5206\u5de5\u5e7e\u5341\u500b\u81e8\u5e8a\u524d\u9805\u76ee\uff0c\u5c08\u6ce8\u5168\u7403\u5275\u65b0\u9805\u76ee\u53ca\u524d\u6cbf\u6280\u8853\u5e73\u53f0\uff0c\u52a0\u901f\u79d1\u5b78\u6210\u679c\u8f49\u5316 \u6d77\u5916\u958b\u767c\u8a3b\u518a\u5718\u968a\u5df2\u5efa\u7acb\u5230\u4f4d\uff0c\u652f\u6301\u5168\u7403\u7ba1\u7dda\u958b\u767c
\n\u5168\u7403\u81e8\u5e8a\u9805\u76ee\u8a08\u5283\u555f\u52d5\uff1a
\nIBI-363\uff08PD-1\/IL-2\uff09\u548c IBI-343\uff08CLDN18.2 ADC\uff09\u4e0b\u534a\u5e74\u5728\u6fb3\u5927\u5229\u4e9e\u555f\u52d5\u81e8\u5e8a\u7814\u7a76 \u5e73\u53f0\u578b\u81e8\u5e8aI\u671f\u7814\u7a76IND\u7533\u8acb\u7372\u7f8e\u570bFDA\u6279\u51c6\uff0c\u7528\u65bc\u958b\u5c55\u9ed1\u8272\u7d20\u7624\u81e8\u5e8a\u7814\u7a76 \u6301\u7e8c\u63a8\u9032\u66f4\u591a\u5275\u65b0\u5206\u5b50\u9032\u5165\u5168\u7403\u81e8\u5e8a\u958b\u767c <\/p>\n

\u300c\u51fa\u6d77\u300d\u65b0\u8208\u5e02\u5834\u53d6\u5f97\u7a81\u7834\uff1a
\n\u8c9d\u4f10\u73e0\u55ae\u6297\u9054\u6538\u540c\u00ae\u00a0\uff08\u5370\u5c3c\u5546\u54c1\u540dBevagen\u00ae\uff09\u5728\u5370\u5ea6\u5c3c\u897f\u4e9e\u7372\u5f97\u6279\u51c6\uff0c\u6709\u671b\u6210\u70ba\u9996\u500b\u5728\u6771\u5357\u4e9e\u5546\u696d\u5316\u548c\u672c\u5730\u5316\u751f\u7522\u7684\u4e2d\u570b\u6297\u9ad4\u85e5\u3002 <\/p>\n

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\n\u8207\u79ae\u4f86\u88fd\u85e5\u9032\u4e00\u6b65\u6df1\u5316\u816b\u7624\u9818\u57df\u6230\u7565\u5408\u4f5c\uff0c\u7372\u5f97\u5e0c\u5189\u64c7\u00ae\uff08\u96f7\u83ab\u897f\u5c24\u55ae\u6297\uff09\u548cRetsevmo\u00ae\uff08\u585e\u666e\u66ff\u5c3c\uff09\u5728\u4e2d\u570b\u7684\u7368\u5bb6\u5546\u696d\u5316\u6b0a\u5229\uff0c\u4ee5\u53capirtobrutinib\uff08BTK\u6291\u5236\u5291\uff09\u672a\u4f86\u5728\u4e2d\u570b\u5546\u696d\u5316\u6b0a\u5229\u7684\u512a\u5148\u8ac7\u5224\u6b0a\u3002 <\/p>\n

\u9ad8\u8cea\u91cf\u898f\u6a21\u5316\u751f\u7522<\/p>\n

60,000\u5347\u7522\u80fd\uff1a\u64c1\u6709\u570b\u5167\u6700\u5927\u898f\u6a21\u7684\u4e0d\u92b9\u92fc\u751f\u7522\u7522\u80fd\uff0c\u66f4\u591a\u7522\u80fd\u898f\u5283\u4e2d
\n\u6309\u7167\u570b\u969b\u8cea\u91cf\u6a19\u6e96\u9032\u884c\u751f\u7522\u904b\u71df,\u5927\u898f\u6a21\u4e0d\u92b9\u92fc\u751f\u7522\u6210\u672c\u512a\u52e2\u660e\u986f<\/p>\n

\u8ca1\u52d9\u56de\u9867 \u52a0\u901f\u767c\u5c55<\/p>\n

\u7e3d\u6536\u516522.40\u5104\u4eba\u6c11\u5e63\uff0c\u540c\u6bd4\u589e\u957715.3% \u7814\u767c\u6295\u516510.78\u5104\u4eba\u6c11\u5e63\uff0c\u540c\u6bd4\u589e\u957722.5% \u6de8\u8667\u640d10.85\u5104\u4eba\u6c11\u5e63\uff0c\u4e3b\u8981\u7531\u65bc\u6301\u7e8c\u7684\u7814\u767c\u6295\u5165 \u5728\u624b\u73fe\u91d1\u7d04\u540815\u5104\u7f8e\u5143, \u70ba\u516c\u53f8\u6301\u7e8c\u5c08\u6ce8\u65bc\u9577\u671f\u767c\u5c55\u63d0\u4f9b\u5805\u5be6\u4fdd\u969c[1]<\/p>\n

\n

[1].\u622a\u81f3\u672c\u65b0\u805e\u767c\u4f48\u65e5\u671f\uff0c\u5176\u4e2d\u5305\u62ec2022\u5e748\u6708\u8207\u8cfd\u8afe\u83f2\u7c3d\u8a02\u6230\u7565\u5408\u4f5c\u5354\u8b70\u6536\u5230\u50f9\u503c3\u5104\u6b50\u5143\u73fe\u91d1\u7684\u80a1\u6b0a\u6295\u8cc7\u3002\u672c\u6587\u4e2d\u63d0\u53ca\u7684\u8ca1\u52d9\u6578\u64da\u63a1\u7528\u4e86\u975e\u570b\u969b\u8ca1\u52d9\u5831\u544a\u6e96\u5247\u8a08\u91cf\uff0c\u8a73\u60c5\u8acb\u53c3\u95b1\u96c6\u5718\u696d\u7e3e\u516c\u544a\u3002<\/span><\/p>\n<\/div>\n

\u95dc\u65bc\u4fe1\u9054\u751f\u7269<\/p>\n

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\u8a73\u60c5\u8acb\u8a2a\u554f\u516c\u53f8\u7db2\u7ad9\uff1awww.innoventbio.com<\/a>\u6216\u516c\u53f8\u9818\u82f1\u8cec\u865f\uff1aInnovent Biologics\u3002<\/p>\n

\u524d\u77bb\u6027\u8072\u660e<\/p>\n

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\u7e7c\u7e8c\u63d0\u5347\u92b7\u552e\u7522\u51fa\uff0c\u517c\u9867\u63d0\u9ad8\u6548\u76ca\uff0c\u652f\u6301\u696d\u52d9\u9577\u671f\u53ef\u6301\u7e8c\u5065\u5eb7\u767c\u5c55 34\u500b\u96c4\u539a\u7684\u7814\u767c\u7ba1\u7dda \u9ad8\u6f5b\u5206\u5b50\u9010\u6b65\u8b80\u51fa\u6578\u64da 7\u500b\u7522\u54c1\u7372\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c3\u500b\u54c1\u7a2e\u5728NMPA\u5be9\u8a55\u4e2d\uff0c4\u500b\u54c1\u7a2e\u9032\u5165III\u671f\u6216\u95dc\u9375\u6027\u81e8\u5e8a\u7814\u7a76\uff0c\u53e6\u670920\u500b\u7522\u54c1\u5df2\u9032\u5165\u81e8\u5e8a\u7814\u7a76\u3002 \u816b\u7624\uff1a25\u500b\u96c4\u539a\u7684\u7814\u767c\u7ba1\u7dda\uff0c\u5168\u9762\u8986\u84cb\u4e3b\u8981\u816b\u7624\u9818\u57df PD-1\u9818\u5148\u54c1\u724c\u9054\u4f2f\u8212\u00ae\uff1a \u65b0\u589e\u4e09\u9805\u9ad8\u767c\u7624\u7a2e\u4e00\u7dda\u9069\u61c9\u75c7\u7d0d\u5165\u570b\u5bb6\u91ab\u4fdd\u76ee\u9304\uff08\u975e\u9c57\u72c0\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u3001\u9c57\u72c0\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u3001\u809d\u764c\uff09 \u65b0\u589e\u4e00\u7dda\u98df\u7ba1\u764c\u548c\u4e00\u7dda\u80c3\u764c\u5169\u5927\u9069\u61c9\u75c7\u7372\u6279 \u5169\u9805NDA\uff0c\u591a\u500b\u8a3b\u518a\/\u95dc\u9375\u81e8\u5e8a\u7814\u7a76\uff1a Retsevmo\u00ae\uff08\u585e\u666e\u66ff\u5c3c\uff09\uff0c\u5df2\u905e\u4ea4NDA IBI-326 (BCMA CAR-T) \uff0c\u5df2\u905e\u4ea4NDA IBI-310 (CTLA-4) IBI-344 (ROS1\/NTRK) IBI-376 (PI3K\u03b4) IBI-126 (CEACAM5 ADC) \u767c\u4f48\u591a\u500b\u5168\u7403\u5275\u65b0\u5206\u5b50\u521d\u6b65\u7a4d\u6975\u81e8\u5e8a\u7814\u7a76\u6578\u64da\uff1a IBI-110 (LAG3)\uff1a \u4e00\u7dda\u80ba\u9c57\u764c\uff0c\u4e00\u7dda\u80c3\u764c IBI-188 (CD47): \u4e00\u7dda\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81 IBI-351 (KRASG12C): \u80ba\u764c\uff0c\u7d50\u76f4\u8178\u764c IBI-344 (ROS1\/NTRK) :\u80ba\u764c \u975e\u816b\u7624\uff1a9\u6b3e\u9ad8\u5ea6\u5dee\u7570\u5316\u5206\u5b50\u5e36\u4f86\u539a\u7a4d\u8584\u767c\u7684\u589e\u9577\u7a7a\u9593 \u4e00\u9805NDA\uff0c\u5546\u696d\u5316\u6709\u671b\u518d\u6dfb\u65b0\u6210\u54e1 IBI-306 (PCSK9) \uff0c\u5df2\u905e\u4ea4NDA \u4eae\u773c\u4e8c\u671f\u6578\u64da\u983b\u51fa\uff0c\u65b0\u589e\u5169\u500b\u5206\u5b50\u5373\u5c07\u9032\u5165\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76 IBI-362 (GLP-1\/GCGR) \uff1a\u6e1b\u91cd\u548c\u7cd6\u5c3f\u75c5\u4e8c\u671f\u7d50\u679c\u8b80\u51fa\uff1a\u5f37\u52c1\u7684\u6e1b\u91cd\u548c\u964d\u7cd6\u6548\u679c\u53ca\u4e00\u7cfb\u5217\u65b0\u9673\u4ee3\u8b1d\u7372\u76ca\u30022022\u5e74\u5e95\u81f32023\u5e74\u521d\u9032\u5165\u6e1b\u91cd\u53ca\u7cd6\u5c3f\u75c5\u96d9\u9805\u9069\u61c9\u75c7III\u671f\u81e8\u5e8a\u7814\u7a76\u3002 IBI-112 (IL-23p19)\uff1a\u9280\u5c51\u75c5\u4e8c\u671f\u7d50\u679c\u8b80\u51fa\uff1a\u6f5b\u5728\u7684\u9577\u671f\u7642\u6548\u512a\u52e2\u548c\u5ef6\u9577\u7d66\u85e5\u9593\u9694\u7684\u4fbf\u5229\u6027\u30022022\u5e74\u4e0b\u534a\u5e74\u9032\u5165\u9280\u5c51\u75c5III\u671f\u81e8\u5e8a\u7814\u7a76\u3002 \u6301\u7e8c\u63a8\u9032\u5168\u7403\u5275\u65b0\u7684\u6838\u5fc3\u767c\u5c55\u6230\u7565 \u7f8e\u570b\u7814\u767c\u4e2d\u5fc3\u53ca\u6d77\u5916\u958b\u767c\u8a3b\u518a\u5718\u968a\u5efa\u8a2d\uff1a \u7f8e\u570b\u7814\u767c\u4e2d\u5fc3\u5168\u65b9\u4f4d\u6295\u5165\u904b\u71df\uff0c\u570b\u6e05\u9662\u4e2d\u7f8e\u5718\u968a\u4e09\u767e\u4f4d\u79d1\u5b78\u5bb6\u5354\u4f5c\u5206\u5de5\u5e7e\u5341\u500b\u81e8\u5e8a\u524d\u9805\u76ee\uff0c\u5c08\u6ce8\u5168\u7403\u5275\u65b0\u9805\u76ee\u53ca\u524d\u6cbf\u6280\u8853\u5e73\u53f0\uff0c\u52a0\u901f\u79d1\u5b78\u6210\u679c\u8f49\u5316 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\u7372\u6279\u54c1\u7a2e\u589e\u52a0\u81f3\u4e03\u6b3e\uff1a\u9054\u4f2f\u8212\u00ae\u3001\u9054\u6538\u540c\u00ae\u3001\u8607\u7acb\u4fe1\u00ae\u3001\u9054\u4f2f\u83ef\u00ae\u3001\u9054\u4f2f\u5766\u00ae\u3001\u8010\u7acb\u514b\u00ae\u3001\u5e0c\u5189\u64c7\u00ae \u7522\u54c1\u6536\u516520.41\u5104\u4eba\u6c11\u5e63\uff0c\u540c\u6bd4\u589e\u957710.0%\uff0c\u7522\u54c1\u4fdd\u6301\u5feb\u901f\u653e\u91cf,\u5354\u540c\u50f9\u503c\u91cb\u653e \u5ee3\u95ca\u7684\u6e20\u9053\u8986\u84cb\u548c\u5c08\u696d\u7684\u5546\u696d\u5316\u5718\u968a\u57fa\u790e\uff1a\u8d855000\u5bb6\u91ab\u9662\u8986\u84cb\uff0c\u8fd13000\u4eba\u5546\u696d\u5316\u5718\u968a \u5546\u696d\u5316\u7ba1\u7406\u518d\u5347\u7d1a\uff0c\u555f\u75282.0\u6a21\u5f0f\uff1a \u696d\u52d9\u67b6\u69cb\u8abf\u6574\u5347\u7d1a\uff0c\u6253\u9020\u5c08\u696dBU\u6a21\u5f0f\uff0c\u9ad8\u6548\u7cbe\u6e96\u71df\u92b7\u9ad4\u7cfb \u7e7c\u7e8c\u63d0\u5347\u92b7\u552e\u7522\u51fa\uff0c\u517c\u9867\u63d0\u9ad8\u6548\u76ca\uff0c\u652f\u6301\u696d\u52d9\u9577\u671f\u53ef\u6301\u7e8c\u5065\u5eb7\u767c\u5c55 34\u500b\u96c4\u539a\u7684\u7814\u767c\u7ba1\u7dda \u9ad8\u6f5b\u5206\u5b50\u9010\u6b65\u8b80\u51fa\u6578\u64da 7\u500b\u7522\u54c1\u7372\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c3\u500b\u54c1\u7a2e\u5728NMPA\u5be9\u8a55\u4e2d\uff0c4\u500b\u54c1\u7a2e\u9032\u5165III\u671f\u6216\u95dc\u9375\u6027\u81e8\u5e8a\u7814\u7a76\uff0c\u53e6\u670920\u500b\u7522\u54c1\u5df2\u9032\u5165\u81e8\u5e8a\u7814\u7a76\u3002 \u816b\u7624\uff1a25\u500b\u96c4\u539a\u7684\u7814\u767c\u7ba1\u7dda\uff0c\u5168\u9762\u8986\u84cb\u4e3b\u8981\u816b\u7624\u9818\u57df PD-1\u9818\u5148\u54c1\u724c\u9054\u4f2f\u8212\u00ae\uff1a \u65b0\u589e\u4e09\u9805\u9ad8\u767c\u7624\u7a2e\u4e00\u7dda\u9069\u61c9\u75c7\u7d0d\u5165\u570b\u5bb6\u91ab\u4fdd\u76ee\u9304\uff08\u975e\u9c57\u72c0\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u3001\u9c57\u72c0\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u3001\u809d\u764c\uff09 \u65b0\u589e\u4e00\u7dda\u98df\u7ba1\u764c\u548c\u4e00\u7dda\u80c3\u764c\u5169\u5927\u9069\u61c9\u75c7\u7372\u6279 \u5169\u9805NDA\uff0c\u591a\u500b\u8a3b\u518a\/\u95dc\u9375\u81e8\u5e8a\u7814\u7a76\uff1a Retsevmo\u00ae\uff08\u585e\u666e\u66ff\u5c3c\uff09\uff0c\u5df2\u905e\u4ea4NDA IBI-326 (BCMA CAR-T) \uff0c\u5df2\u905e\u4ea4NDA IBI-310 (CTLA-4) IBI-344 (ROS1\/NTRK) IBI-376 (PI3K\u03b4) IBI-126 (CEACAM5 ADC) \u767c\u4f48\u591a\u500b\u5168\u7403\u5275\u65b0\u5206\u5b50\u521d\u6b65\u7a4d\u6975\u81e8\u5e8a\u7814\u7a76\u6578\u64da\uff1a IBI-110 (LAG3)\uff1a \u4e00\u7dda\u80ba\u9c57\u764c\uff0c\u4e00\u7dda\u80c3\u764c IBI-188 (CD47): \u4e00\u7dda\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81 IBI-351 (KRASG12C): \u80ba\u764c\uff0c\u7d50\u76f4\u8178\u764c IBI-344 (ROS1\/NTRK) :\u80ba\u764c \u975e\u816b\u7624\uff1a9\u6b3e\u9ad8\u5ea6\u5dee\u7570\u5316\u5206\u5b50\u5e36\u4f86\u539a\u7a4d\u8584\u767c\u7684\u589e\u9577\u7a7a\u9593 \u4e00\u9805NDA\uff0c\u5546\u696d\u5316\u6709\u671b\u518d\u6dfb\u65b0\u6210\u54e1 IBI-306 (PCSK9) \uff0c\u5df2\u905e\u4ea4NDA \u4eae\u773c\u4e8c\u671f\u6578\u64da\u983b\u51fa\uff0c\u65b0\u589e\u5169\u500b\u5206\u5b50\u5373\u5c07\u9032\u5165\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76 IBI-362 (GLP-1\/GCGR) \uff1a\u6e1b\u91cd\u548c\u7cd6\u5c3f\u75c5\u4e8c\u671f\u7d50\u679c\u8b80\u51fa\uff1a\u5f37\u52c1\u7684\u6e1b\u91cd\u548c\u964d\u7cd6\u6548\u679c\u53ca\u4e00\u7cfb\u5217\u65b0\u9673\u4ee3\u8b1d\u7372\u76ca\u30022022\u5e74\u5e95\u81f32023\u5e74\u521d\u9032\u5165\u6e1b\u91cd\u53ca\u7cd6\u5c3f\u75c5\u96d9\u9805\u9069\u61c9\u75c7III\u671f\u81e8\u5e8a\u7814\u7a76\u3002 IBI-112 (IL-23p19)\uff1a\u9280\u5c51\u75c5\u4e8c\u671f\u7d50\u679c\u8b80\u51fa\uff1a\u6f5b\u5728\u7684\u9577\u671f\u7642\u6548\u512a\u52e2\u548c\u5ef6\u9577\u7d66\u85e5\u9593\u9694\u7684\u4fbf\u5229\u6027\u30022022\u5e74\u4e0b\u534a\u5e74\u9032\u5165\u9280\u5c51\u75c5III\u671f\u81e8\u5e8a\u7814\u7a76\u3002 \u6301\u7e8c\u63a8\u9032\u5168\u7403\u5275\u65b0\u7684\u6838\u5fc3\u767c\u5c55\u6230\u7565 \u7f8e\u570b\u7814\u767c\u4e2d\u5fc3\u53ca\u6d77\u5916\u958b\u767c\u8a3b\u518a\u5718\u968a\u5efa\u8a2d\uff1a \u7f8e\u570b\u7814\u767c\u4e2d\u5fc3\u5168\u65b9\u4f4d\u6295\u5165\u904b\u71df\uff0c\u570b\u6e05\u9662\u4e2d\u7f8e\u5718\u968a\u4e09\u767e\u4f4d\u79d1\u5b78\u5bb6\u5354\u4f5c\u5206\u5de5\u5e7e\u5341\u500b\u81e8\u5e8a\u524d\u9805\u76ee\uff0c\u5c08\u6ce8\u5168\u7403\u5275\u65b0\u9805\u76ee\u53ca\u524d\u6cbf\u6280\u8853\u5e73\u53f0\uff0c\u52a0\u901f\u79d1\u5b78\u6210\u679c\u8f49\u5316 \u6d77\u5916\u958b\u767c\u8a3b\u518a\u5718\u968a\u5df2\u5efa\u7acb\u5230\u4f4d\uff0c\u652f\u6301\u5168\u7403\u7ba1\u7dda\u958b\u767c \u5168\u7403\u81e8\u5e8a\u9805\u76ee\u8a08\u5283\u555f\u52d5\uff1a IBI-363\uff08PD-1\/IL-2\uff09\u548c IBI-343\uff08CLDN18.2 ADC\uff09\u4e0b\u534a\u5e74\u5728\u6fb3\u5927\u5229\u4e9e\u555f\u52d5\u81e8\u5e8a\u7814\u7a76 \u5e73\u53f0\u578b\u81e8\u5e8aI\u671f\u7814\u7a76IND\u7533\u8acb\u7372\u7f8e\u570bFDA\u6279\u51c6\uff0c\u7528\u65bc\u958b\u5c55\u9ed1\u8272\u7d20\u7624\u81e8\u5e8a\u7814\u7a76 \u6301\u7e8c\u63a8\u9032\u66f4\u591a\u5275\u65b0\u5206\u5b50\u9032\u5165\u5168\u7403\u81e8\u5e8a\u958b\u767c \u300c\u51fa\u6d77\u300d\u65b0\u8208\u5e02\u5834\u53d6\u5f97\u7a81\u7834\uff1a 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\u6309\u7167\u570b\u969b\u8cea\u91cf\u6a19\u6e96\u9032\u884c\u751f\u7522\u904b\u71df,\u5927\u898f\u6a21\u4e0d\u92b9\u92fc\u751f\u7522\u6210\u672c\u512a\u52e2\u660e\u986f \u8ca1\u52d9\u56de\u9867 \u52a0\u901f\u767c\u5c55 \u7e3d\u6536\u516522.40\u5104\u4eba\u6c11\u5e63\uff0c\u540c\u6bd4\u589e\u957715.3% \u7814\u767c\u6295\u516510.78\u5104\u4eba\u6c11\u5e63\uff0c\u540c\u6bd4\u589e\u957722.5% \u6de8\u8667\u640d10.85\u5104\u4eba\u6c11\u5e63\uff0c\u4e3b\u8981\u7531\u65bc\u6301\u7e8c\u7684\u7814\u767c\u6295\u5165 \u5728\u624b\u73fe\u91d1\u7d04\u540815\u5104\u7f8e\u5143, \u70ba\u516c\u53f8\u6301\u7e8c\u5c08\u6ce8\u65bc\u9577\u671f\u767c\u5c55\u63d0\u4f9b\u5805\u5be6\u4fdd\u969c[1] 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