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\u694a\u535a\u58eb\u57281985\u5e747\u6708\u65bc\u4e2d\u570b\u6e56\u5317\u7684\u6e56\u5317\u91ab\u5b78\u9662\u54b8\u5be7\u5206\u9662\uff08\u73fe\u6e56\u5317\u79d1\u6280\u5b78\u9662\uff09\u7372\u5f97\u91ab\u5b78\u5b78\u58eb\u5b78\u4f4d\uff0c1989\u5e747\u6708\u5728\u4e2d\u570b\u5357\u4eac\u7684\u5357\u4eac\u91ab\u5b78\u9662\uff08\u73fe\u7a31\u5357\u4eac\u91ab\u79d1\u5927\u5b78\uff09\u7372\u5f97\u75c5\u7406\u751f\u7406\u5b78\u78a9\u58eb\u5b78\u4f4d\u3002\u5176\u5f8c\u57281995\u5e746\u6708\u65bc\u7f8e\u570b\u9054\u62c9\u65af\u7684\u5f97\u514b\u85a9\u65af\u5927\u5b78\u897f\u5357\u91ab\u5b78\u4e2d\u5fc3\u7372\u5f97\u5206\u5b50\u907a\u50b3\u5b78\u535a\u58eb\u5b78\u4f4d\uff0c\u5e2b\u5f9e\u8afe\u8c9d\u723e\u734e\u5f97\u4e3bMichael S. Brown\u535a\u58eb\u548cJoseph L. Goldstein\u535a\u58eb\u3002\u65bc1995\u5e74\u81f31998\u5e74\u9593\u5728\u7f8e\u570b\u54c8\u4f5b\u5927\u5b78\u9032\u884c\u5316\u5b78\u751f\u7269\u5b78\u535a\u58eb\u5f8c\u57f9\u8a13\uff0c\u5e2b\u5f9eStuart L. Schreiber\u535a\u58eb\u3002<\/p>\n

\u696d\u52d9\u9032\u5c55<\/p>\n

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\u2013\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u6211\u5011\u70baMTC\u60a3\u8005RET\u57fa\u56e0\u8b8a\u7570\u6aa2\u6e2c\u63d0\u4f9b\u63f4\u52a9\u65b9\u6848\uff0c\u4e26\u5c07\u6aa2\u6e2c\u63f4\u52a9\u9805\u76ee\u64f4\u5c55\u81f3IDH1\u7a81\u8b8a\u60a3\u8005\u3002
\u2013\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u9664\u75c5\u7406\u5b78\u5bb6\u5916\uff0c\u6211\u5011\u4ea6\u52a0\u5f37\u81e8\u5e8a\u91ab\u751f\u53c3\u8207\u6aa2\u6e2c\u76f8\u95dc\u5b78\u8853\u6d3b\u52d5\uff0c\u4ee5\u9032\u4e00\u6b65\u63d0\u9ad8\u6aa2\u6e2c\u8a8d\u77e5\u3002
\n\u5efa\u7acb\u5ee3\u6cdb\u7684\u884c\u696d\u548c\u5b78\u8853\u8a8d\u77e5\u5ea6\uff0c\u6a39\u7acb\u54c1\u724c\u548c\u79d1\u5b78\u9818\u5c0e\u529b
\u2013\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u666e\u5409\u83ef\u00ae\uff08\u666e\u62c9\u66ff\u5c3c\uff09\u3001\u6cf0\u5409\u83ef\u00ae\uff08\u963f\u4f10\u66ff\u5c3c\uff09\u53ca\u62d3\u8212\u6c83\u00ae\uff08\u827e\u4f0f\u5c3c\u5e03\uff09\u5df2\u7d0d\u5165CSCO NSCLC\/\u80c3\u8178\u9053\u9593\u8cea\u7624\uff08GIST\uff09\u8a3a\u7642\u6307\u5357\u3001\u4e2d\u83ef\u91ab\u5b78\u6703\u6307\u5357\u53ca\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u5206\u5b50\u75c5\u7406\u6aa2\u6e2c\u81e8\u5e8a\u5be6\u8e10\u6307\u5357\u7b4915 \u9805\u4e2d\u570b\u570b\u5bb6\u6307\u5357\uff0c\u5efa\u7acb\u4e86\u7528\u65bc\u591a\u500b\u6cbb\u7642\u9818\u57df\uff08NSCLC\u3001TC\u3001GIST\u53caAML\uff09\u7684\u6cbb\u7642\u6a21\u5f0f\u3002
\u2013\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u6211\u5011\u8207\u4e2d\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\u3001\u4e2d\u570b\u6297\u764c\u5354\u6703\u53ca\u4e2d\u570b\u91ab\u5e2b\u5354\u6703\u7b49\u591a\u500b\u884c\u696d\u5354\u6703\u5c31GIST\u3001NSCLC\u53ca\u60e1\u6027\u8840\u6db2\u816b\u7624\u7684\u8a3a\u65b7\u53ca\u6cbb\u7642\u6a19\u6e96\u5316\u9805\u76ee\u5c55\u958b\u5bc6\u5207\u5408\u4f5c\uff0c\u9032\u4e00\u6b65\u52a0\u5f37\u6211\u5011\u7684\u884c\u696d\u806f\u7e6b\u4e26\u5c55\u793a\u6211\u5011\u7684\u5c08\u696d\u80fd\u529b\u3002
\u2013\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u901a\u904e\u7a4d\u6975\u53c3\u8207\u53ca\u6301\u7e8c\u6559\u80b2\uff0c\u6211\u5011\u63d0\u9ad8\u4e86\u91ab\u751f\u53ca\u95dc\u9375\u610f\u898b\u9818\u8896\uff08KOL\uff09\u5c0d\u65bc\u6211\u5011\u7522\u54c1\u7684\u8a8d\u8b58\u3002\u622a\u81f3\u672c\u516c\u544a\u65e5\u671f\uff0c\u6211\u5011\u53ec\u958b\u8d85\u904e80 \u6b21\u5b78\u8853\u6703\u8b70\uff0c\u89f8\u9054\u8d85\u904e80,000 \u540d\u91cd\u8981\u7684KOL \u548c\u91ab\u7642\u5c08\u696d\u4eba\u58eb\uff08HCP\uff09\uff0c\u63d0\u9ad8\u4e86\u91ab\u7642\u5404\u76f8\u95dc\u65b9\u5c0d\u6211\u5011\u85e5\u7269\u6cbb\u7642\u7684\u8a8d\u8b58\u3002
\u2013\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u6211\u5011\u8d0a\u52a9\u9818\u5148\u7684KOL\u958b\u5c55\u85e5\u7269\u7372\u6279\u5f8c\u7684\u81e8\u5e8a\u9805\u76ee\uff0c\u5982\u7814\u7a76\u8005\u767c\u8d77\u7684\u8a66\u9a57\u548c\u771f\u5be6\u4e16\u754c\u7684\u7814\u7a76\uff0c\u4ee5\u5728\u591a\u500b\u764c\u75c7\u9069\u61c9\u75c7\u4e2d\u7372\u5f97\u66f4\u591a\u6578\u64da\uff0c\u5f9e\u800c\u652f\u6301\u6211\u5011\u85e5\u7269\u7684\u4f7f\u7528\u3002\u6211\u5011\u4e5f\u63d0\u4f9b\u8cc7\u91d1\u8207\u975e\u76c8\u5229\u5b78\u8853\u6a5f\u69cb\u5408\u4f5c\u958b\u5c55\u7814\u7a76\u3002\u5c24\u5176\u662f\uff0c2\u9805\u771f\u5be6\u4e16\u754c\u7814\u7a76\u5df2\u9054\u81f4\u91cc\u7a0b\u7891\uff0c\u5305\u62ec\u843d\u5be6\u666e\u62c9\u66ff\u5c3c\u7528\u65bc\u6cbb\u7642\u535a\u9c32NSCLC\u7684\u81e8\u5e8a\u7814\u7a76\u5831\u544a\uff0c\u4ee5\u53ca\u555f\u52d5\u963f\u4f10\u66ff\u5c3c\u7528\u65bc\u6cbb\u7642GIST\u60a3\u8005\u76842\u500b\u8a66\u9a57\u4e2d\u5fc3\u3002
\n\u5236\u5b9a\u4e00\u7cfb\u5217\u65b9\u6cd5\uff0c\u63d0\u9ad8\u6211\u5011\u85e5\u54c1\u7684\u53ef\u53ca\u6027\u53ca\u53ef\u8ca0\u64d4\u6027
\u2013\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u6211\u5011\u5df2\u66f4\u65b0\u4e0a\u5e02\u7522\u54c1\u7684\u5b9a\u50f9\u7b56\u7565\u3002\u5177\u9ad4\u800c\u8a00\uff0c\u8abf\u6574\u6cf0\u5409\u83ef\u00ae\uff08\u963f\u4f10\u66ff\u5c3c\uff09\u7684\u4e0a\u5e02\u50f9\u683c\u4ee5\u63d0\u9ad8\u7b2c\u4e00\u500b\u6cbb\u7642\u9031\u671f\u7684\u53ef\u8ca0\u64d4\u6027\u3002\u66f4\u65b0\u666e\u5409\u83ef\u00ae\uff08\u666e\u62c9\u66ff\u5c3c\uff09\u60a3\u8005\u63f4\u52a9\u9805\u76ee\uff08PAP\uff09\uff0c\u4ee5\u652f\u6301\u60a3\u8005\u9577\u671f\u7684\u6cbb\u7642\u3002
\u2013\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u8aa0\u5982\u6211\u5011\u76842021\u5e74\u5e74\u5ea6\u696d\u7e3e\u516c\u544a\u6240\u62ab\u9732\uff0c\u6211\u5011\u5c07\u6cf0\u5409\u83ef\u00ae\uff08\u963f\u4f10\u66ff\u5c3c\uff09\u53ca\u666e\u5409\u83ef\u00ae\uff08\u666e\u62c9\u66ff\u5c3c\uff09\u7d0d\u5165\u591a\u9805\u4e3b\u8981\u5546\u696d\u53ca\u653f\u5e9c\u4fdd\u96aa\u8a08\u5283\uff0c\u5f9e60 \u591a\u9805\u589e\u52a0\u81f385 \u9805\u3002
\u2013\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u6211\u5011\u7e7c\u7e8c\u8207\u570b\u85e5\u63a7\u80a1\u80a1\u4efd\u6709\u9650\u516c\u53f8\uff08\u570b\u85e5\u63a7\u80a1\uff09\u9032\u884c\u6230\u7565\u5408\u4f5c\uff0c\u64f4\u5927\u666e\u5409\u83ef\u00ae\uff08\u666e\u62c9\u66ff\u5c3c\uff09\u53ca\u6cf0\u5409\u83ef\u00ae\uff08\u963f\u4f10\u66ff\u5c3c\uff09\u5728\u91ab\u9662\u53ca\u85e5\u5e97\u7684\u5206\u92b7\u7bc4\u570d\u3002\u622a\u81f3\u672c\u516c\u544a\u65e5\u671f\uff0c\u6cf0\u5409\u83ef\u00ae\uff08\u963f\u4f10\u66ff\u5c3c\uff09\u3001\u666e\u5409\u83ef\u00ae\uff08\u666e\u62c9\u66ff\u5c3c\uff09\u53ca\u62d3\u8212\u6c83\u00ae\uff08\u827e\u4f0f\u5c3c\u5e03\uff09\u5df2\u5b8c\u6210\u7d04150\u5bb6\u91ab\u9662\u53caDTP\u5217\u540d\uff0c\u800c2021\u5e74\u7d04\u70ba100\u5bb6\u3002
\u2013\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u6211\u5011\u7e7c\u7e8c\u8207\u4e2d\u570b\u5927\u9678\u4e09\u5927\u7d9c\u5408\u5275\u65b0\u91ab\u7642\u670d\u52d9\u5e73\u53f0\uff0d\u4e0a\u6d77\u9382\u4fe1\u5065\u5eb7\u79d1\u6280\u6709\u9650\u516c\u53f8\u3001\u5317\u4eac\u5713\u5fc3\u79d1\u6280\u96c6\u5718\u80a1\u4efd\u6709\u9650\u516c\u53f8\u53ca\u601d\u6d3e\u5065\u5eb7\u79d1\u6280\u6709\u9650\u516c\u53f8\u9032\u884c\u6230\u7565\u5408\u4f5c\uff0c\u901a\u904e\u4fc3\u9032\u57ce\u5e02\u4fdd\u96aa\u9805\u76ee\u7684\u5165\u7d44\uff0c\u63d0\u9ad8\u666e\u5409\u83ef\u00ae\uff08\u666e\u62c9\u66ff\u5c3c\uff09\u3001\u6cf0\u5409\u83ef\u00ae\uff08\u963f\u4f10\u66ff\u5c3c\uff09\u53ca\u62d3\u8212\u6c83\u00ae\uff08\u827e\u4f0f\u5c3c\u5e03\uff09\u7684\u5206\u92b7\u53ca\u53ef\u8ca0\u64d4\u6027\u3002
\n\u5c31\u4f9d\u5f9e\u53ca\u9577\u671f\u7528\u85e5\u5c0d\u91ab\u751f\u2571\u60a3\u8005\u9032\u884c\u6301\u7e8c\u6559\u80b2\u53ca\u652f\u6301
\u2013\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u6211\u5011\u901a\u904e\u5728\u7dda\u5e73\u53f0\u7e7c\u7e8c\u71df\u904b\u75be\u75c5\u7ba1\u7406\u8a08\u5283\uff0c\u70ba\u91ab\u7642\u5c08\u696d\u4eba\u58eb\u63d0\u4f9b\u6709\u95dc\u9577\u671f\u6cbb\u7642\u7684\u6559\u80b2\uff0c\u4e26\u70ba\u60a3\u8005\u63d0\u4f9b\u6559\u80b2\u8ab2\u7a0b\u53ca\u5f8c\u7e8c\u670d\u52d9\uff0c\u4ee5\u652f\u6301\u4f9d\u5f9e\u6027\u3002
\n\u8207\u5168\u7403\u6230\u7565\u5925\u4f34\u5408\u4f5c\uff0c\u652f\u6301\u816b\u7624\u514d\u75ab\u6cbb\u7642\u9aa8\u67b6\u85e5\u7269\u5168\u7403\u4e0a\u5e02
\u2013\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u6211\u5011\u6b63\u8207\u5408\u4f5c\u5925\u4f34\u8f1d\u745e\u53caEQRx\u5c55\u958b\u5bc6\u5207\u5408\u4f5c\uff0c\u4ee5\u63a8\u9032\u8212\u683c\u5229\u55ae\u6297\u5728\u4e2d\u570b\u5927\u9678\u53ca\u5927\u4e2d\u83ef\u4ee5\u5916\u5730\u5340\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u3002
\u2013\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u6211\u5011\u6b63\u8207EQRx\u5c31\u8212\u683c\u5229\u55ae\u6297\u7684\u5168\u7403\u958b\u767c\u53ca\u76e3\u7ba1\u7b56\u7565\u5c55\u958b\u5bc6\u5207\u5408\u4f5c\uff0c\u5305\u62ec\u7f8e\u570b\u3001\u82f1\u570b\u53ca\u6b50\u76df\u4ee5\u53ca\u5176\u4ed6\u5730\u5340\uff0c\u5982\u4e2d\u6771\u3001\u571f\u8033\u5176\u53ca\u975e\u6d32\u7b49\u3002\u7528\u65bc\u6cbb\u7642NSCLC\u3001\u80c3\u764c\u53ca\u98df\u7ba1\u764c\u7684PD-(L)1 \u5168\u7403\u5e02\u5834\u898f\u6a21\u9810\u8a08\u5728\u4e8c\u96f6\u4e8c\u516d\u5e74\u5c07\u9054\u5230\u7d04300\u5104\u7f8e\u5143\u3002 <\/p>\n

II.\u5275\u65b0\u3001\u512a\u8cea\u53ca\u5feb\u901f\u7684\u57f7\u884c\u529b\u5c07\u5f15\u9818\u7ba1\u7dda\u6210\u719f\u767c\u5c55<\/p>\n

\u57fa\u77f3\u85e5\u696d\u8a2d\u5b9a\u5bcc\u6709\u6311\u6230\u6027\u7684\u81e8\u5e8a\u958b\u767c\u9032\u7a0b\u4e26\u9032\u4e00\u6b65\u52a0\u5f37\u5176\u7ba1\u7dda\u3002\u622a\u81f3\u672c\u516c\u544a\u65e5\u671f\uff0c\u6211\u5011\u53d6\u5f974 \u9805NDA\u6279\u51c6\uff0c\u4e26\u5df2\u905e\u4ea42 \u9805NDA\u7533\u8acb\uff0c\u5b8c\u5584\u6211\u5011\u5df2\u4e0a\u5e02\u53ca\u8fd1\u5546\u696d\u5316\u85e5\u7269\u7ba1\u7dda\u7684\u591a\u5143\u5316\u53ca\u6210\u719f\u5ea6\u3002\u7531\u6b64\uff0c\u6211\u5011\u7684\u81e8\u5e8a\u80fd\u529b\u518d\u6b21\u5728\u5275\u65b0\u3001\u901f\u5ea6\u53ca\u8cea\u91cf\u7b49\u65b9\u9762\u812b\u7a4e\u800c\u51fa\u3002\u827e\u4f0f\u5c3c\u5e03\u5f9eNDA \u7372\u53d7\u7406\u5230\u7372\u5f97\u6279\u51c6\u50c5\u7528\u6642\u516d\u500b\u6708\uff0c\u4ee5\u53ca\u6211\u5011\u5728\u5168\u7403\u5b78\u8853\u6703\u8b70\u5c55\u793a\u6216\u9802\u5c16\u91ab\u5b78\u671f\u520a\u767c\u4f487\u9805\u76f8\u95dc\u6578\u64da\u3002<\/p>\n

\u8a73\u60c5\u5982\u4e0b\uff1a<\/p>\n

\u8212\u683c\u5229\u55ae\u6297\uff08C S1001\uff0cPD-L1 \u6297\u9ad4\uff09\uff0c\u6210\u70ba\u552f\u4e00\u7372\u51c6\u7528\u65bcIII \u671f\u548cIV \u671f NSCLC\u7684\u6297PD-1\/PD-L1\u55ae\u514b\u9686\u6297\u9ad4\u3002
\u2013\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 2022\u5e745\u6708\uff0c\u8212\u683c\u5229\u55ae\u6297\u7372\u5f97\u570b\u5bb6\u85e5\u76e3\u5c40\u7684NDA\u6279\u51c6\uff0c\u7528\u65bc\u5728\u63a5\u53d7\u9251\u985e\u85e5\u7269\u70ba\u57fa\u790e\u7684\u540c\u6b65\u6216\u5e8f\u8cab\u653e\u5316\u7642\u5f8c\u672a\u51fa\u73fe\u75be\u75c5\u9032\u5c55\u7684\u3001\u4e0d\u53ef\u5207\u9664\u7684III\u671fNSCLC\u60a3\u8005\u7684\u6cbb\u7642\u3002\u8212\u683c\u5229\u55ae\u6297\u6210\u70ba\u9996\u500b\u7372\u6279\u7528\u65bc\u6b64\u985e\u60a3\u8005\u7fa4\u9ad4\u7684\u6297PD-1\/PD-L1\u55ae\u514b\u9686\u6297\u9ad4\u3002
\u2013\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 2022\u5e745\u6708\uff0c\u6211\u5011\u5ba3\u4f48\uff0c\u8a3b\u518a\u6027\u81e8\u5e8a\u7814\u7a76GEMSTONE-301\u7684\u6700\u7d42PFS\u5206\u6790\u9032\u4e00\u6b65\u8b49\u660e\u4e86\u8212\u683c\u5229\u55ae\u6297\u5728III\u671fNSCLC\u60a3\u8005\u4e2d\u7684\u512a\u7570\u7642\u6548\u548c\u986f\u8457\u81e8\u5e8a\u7372\u76ca\u30022022\u5e748\u6708\uff0c\u8a72\u7814\u7a76\u7684\u8a73\u7d30\u6578\u64da\u57282022\u5e74\u4e16\u754c\u80ba\u764c\u5927\u6703\u516c\u4f48\u3002
\u2013\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 2022\u5e741\u6708\uff0c\u6211\u5011\u5ba3\u4f48\u9810\u5148\u8a2d\u5b9a\u7684OS\u671f\u4e2d\u5206\u6790\u986f\u793a\uff0c\u8212\u683c\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u986f\u8457\u5730\u3001\u6709\u81e8\u5e8a\u610f\u7fa9\u5730\u6539\u5584\u4e86IV\u671fNSCLC\u60a3\u8005\u7684\u7e3d\u751f\u5b58\u671f\uff0c\u8a72\u6578\u64da\u5df2\u57282022\u5e74ASCO\u5e74\u6703\u4e0a\u516c\u4f48\u3002\u967d\u6027OS\u6578\u64da\u5c07\u7528\u65bc\u652f\u6301\u8212\u683c\u5229\u55ae\u6297\u5728\u4e2d\u570b\u4ee5\u5916\u5730\u5340\u7684\u8a3b\u518a\u3002
\u2013\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 2022\u5e741\u6708\uff0c\u6211\u5011\u5ba3\u4f48\uff0cR\/R ENKTL\u7684\u8a3b\u518a\u8a66\u9a57\u5df2\u9054\u5230\u4e3b\u8981\u7814\u7a76\u7d42\u9ede\uff0c\u4e26\u8b49\u660e\u5b8c\u5168\u7de9\u89e3\uff08CR\uff09\u7387\u660e\u986f\u8d85\u904e\u76ee\u524d\u8a72\u985e\u60a3\u8005\u53ef\u7528\u7684\u9776\u5411\u55ae\u85e5\u6cbb\u7642\u7684\u5b8c\u5168\u7de9\u89e3\u7387\u3002\u6211\u5011\u57282022\u5e74ASCO\u5e74\u6703\u4e0a\u4ee5\u53e3\u982d\u532f\u5831\u5f62\u5f0f\u5c55\u793a\u7814\u7a76\u7d50\u679c\u3002
\u2013\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 2022\u5e741\u6708\uff0c\u6211\u5011\u5df2\u5b8c\u6210\u5169\u9805\u4e3b\u8981III\u671f\u8a3b\u518a\u81e8\u5e8a\u8a66\u9a57\u7684\u60a3\u8005\u5165\u7d44\uff0c\u5176\u4e2d\u4e00\u9805\u8a66\u9a57\u7528\u65bc\u4e00\u7dda\u6cbb\u7642\u8f49\u79fb\u6027\u80c3\u817a\u764c\u2571\u80c3\u98df\u7ba1\u7d50\u5408\u90e8\u817a\u764c\uff0c\u53e6\u4e00\u9805\u8a66\u9a57\u7528\u65bc\u4e00\u7dda\u6cbb\u7642\u8f49\u79fb\u6027\u98df\u7ba1\u9c57\u764c\u3002
\u2013\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u5c0d\u65bc\u5927\u4e2d\u83ef\u5340\u4ee5\u5916\u7684\u5e02\u5834\uff0c\u6211\u5011\u6b63\u8207EQRx\u5c55\u958b\u5bc6\u5207\u5408\u4f5c\uff0c\u5c31III\u671f NSCLC\u3001IV\u671fNSCLC\u53caR\/R ENKTL\u9069\u61c9\u75c7\u65bc\u591a\u500b\u570b\u5bb6\u53ca\u5730\u5340\u5c31\u76e3\u7ba1\u7533\u8acb\u5c55\u958b\u8a0e\u8ad6\u3002\u6211\u5011\u9810\u671f\u65bc\u672a\u4f866\u500b\u6708\u5167\u905e\u4ea4\u7f8e\u570b\u4ee5\u5916\u7684\u9996\u500bIV\u671fNSCLC\u4e0a\u5e02\u7533\u8acb\u3002\u540c\u6642\uff0c\u6211\u5011\u8207\u7f8e\u570bFDA \u7684\u5efa\u8a2d\u6027\u8ac7\u8a71\u6b63\u5728\u9032\u884c\uff0c\u4ee5\u66f4\u6e05\u6670\u5730\u77ad\u89e3\u76e3\u7ba1\u8def\u5f91\u3002\u5c31R\/R ENKTL\u800c\u8a00\uff0c\u8212\u683c\u5229\u55ae\u6297\u7372\u5f97\u7f8e\u570bFDA\u7684\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\uff08BTD\uff09\uff0c\u6211\u5011\u9810\u671f\u65bc2023\u5e74\u905e\u4ea4\u751f\u7269\u88fd\u54c1\u8a31\u53ef\u8b49\u7533\u8acb\uff08BLA\uff09\u3002
\nNofazinlimab\uff08CS1003\uff0cPD-1\u6297\u9ad4\uff09
\u2013\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 2022\u5e743\u6708\uff0c\u6211\u5011\u5df2\u5b8c\u6210nofazinlimab\u8207 LENVIMA\u00ae(lenvatinib)\u806f\u5408\u7642\u6cd5\u7528\u65bc\u4e00\u7dda\u6cbb\u7642\u665a\u671fHCC\u60a3\u8005\u7684\u5168\u7403 III\u671f\u8a66\u9a57\u7684\u60a3\u8005\u5165\u7d44\u3002
\u2013\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 2022\u5e746\u6708\uff0c\u6211\u5011\u57282022\u5e74 ASCO \u5e74\u6703\u4e0a\u532f\u5831 nofazinlimab\u8207LENVIMA\u00ae(lenvatinib)\u806f\u5408\u7642\u6cd5\u7528\u65bc\u4e00\u7dda\u6cbb\u7642\u4e2d\u570b HCC\u60a3\u8005\u7684Ib\u671f\u7814\u7a76\u679c\u3002
\n\u666e\u62c9\u66ff\u5c3c\uff08CS3009\uff0cRET\u6291\u5236\u5291\uff09\uff0d\u6211\u5011\u5df2\u53d6\u5f97\u5169\u9805NDA\u6279\u51c6\uff0c\u4e14\u4e00\u9805 NDA\u7533\u8acb\u76ee\u524d\u6b63\u5728\u5be9\u6838\u4e2d\u3002
\u2013\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 2022\u5e743\u6708\uff0c\u570b\u5bb6\u85e5\u76e3\u5c40\u6279\u51c6\u5176\u7528\u65bc\u6cbb\u7642\u665a\u671f\u6216\u8f49\u79fb\u6027RET\u7a81\u8b8aMTC\u53caRET\u878d\u5408\u967d\u6027TC\u60a3\u8005\u7684\u9069\u61c9\u75c7\u3002
\u2013\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 2022\u5e747\u6708\uff0c\u9999\u6e2f\u885b\u751f\u7f72\u6279\u51c6\u5176\u7528\u65bc\u6cbb\u7642\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027RET\u878d\u5408\u967d\u6027NSCLC\u60a3\u8005\u7684\u4e0a\u5e02\u7533\u8acb\u3002
\u2013\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 2022\u5e742\u6708\uff0c\u4e2d\u570b\u53f0\u7063\u98df\u54c1\u85e5\u7269\u7ba1\u7406\u7f72\uff08TFDA\uff09\u53d7\u7406\u4e86\u5176\u7528\u65bc\u6cbb\u7642\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027RET\u878d\u5408\u967d\u6027NSCLC\u3001RET\u7a81\u8b8aMTC\u53ca RET\u878d\u5408\u967d\u6027TC\u60a3\u8005\u7684NDA\u3002
\n\u827e\u4f0f\u5c3c\u5e03\uff08CS3010\uff0cIDH1\u6291\u5236\u5291\uff09\uff0d\u6211\u5011\u5df2\u5c31\u8a72\u7522\u54c1\u53d6\u5f97\u9996\u500bNDA\u6279\u51c6\u3002
\u2013\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 2022\u5e741\u6708\uff0c\u570b\u5bb6\u85e5\u76e3\u5c40\u6279\u51c6\u5176\u7528\u65bc\u6cbb\u7642\u651c\u5e36\u6709IDH1\u7a81\u8b8a\u7684R\/R AML\u6210\u4eba\u60a3\u8005\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\u3002
\n\u6d1b\u62c9\u66ff\u5c3c\uff08ROS-1\u6291\u5236\u5291\uff09
\u2013\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u6211\u5011\u6b63\u8207\u8f1d\u745e\u5408\u4f5c\u5728\u5927\u4e2d\u83ef\u5340\u806f\u5408\u958b\u767c\u6d1b\u62c9\u66ff\u5c3c\uff0c\u7528\u65bc\u6cbb\u7642c-ros oncogene 1\uff08ROS1\uff09\u967d\u6027\u665a\u671fNSCLC\u30022022\u5e745\u6708\uff0c\u6d1b\u62c9\u66ff\u5c3c\u91dd\u5c0d\u6cbb\u7642ROS1 \u967d\u6027\u665a\u671fNSCLC\u7684\u95dc\u9375\u7814\u7a76\u5be6\u73fe\u9996\u4f8b\u60a3\u8005\u5165\u7d44\uff0c\u60a3\u8005\u7e7c\u7e8c\u4ee5\u7a69\u5b9a\u6b65\u4f10\u5165\u7d44\u3002
\nCS5001 (LCB71\uff0cROR1 ADC)
\u2013\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u7372\u5f97\u7f8e\u570bFDA\u7684IND\u7533\u8acb\u6279\u51c6\u53ca\u6fb3\u5927\u5229\u4e9e\u502b\u7406\u59d4\u54e1\u6703\uff08\u300cEC\u300d\uff09\u6279\u51c6\u5f8c\uff0c\u6211\u5011\u958b\u59cb\u5c0d\u8a72\u6f5b\u5728\u540c\u985e\u6700\u512aROR1 ADC\u9032\u884c\u9996\u6b21\u4eba\u9ad4\u8a66\u9a57\uff0c\u4e26\u8fc5\u901f\u63a8\u9032\u5230\u5291\u91cf\u905e\u589e\u90e8\u5206\u7684\u60a3\u8005\u62db\u52df\u968e\u6bb5\u3002\u6b64\u5916\uff0c\u6211\u5011\u57282022\u5e743\u6708\u5411\u570b\u5bb6\u85e5\u76e3\u5c40\u63d0\u4ea4IND\u7533\u8acb\uff0c\u4e262022\u5e745\u6708\u7372\u5f97\u6279\u51c6\u3002\u70ba\u78ba\u4fdd\u751f\u7269\u6a19\u8a18\u7269\u9a45\u52d5\u60a3\u8005\u7684\u9078\u64c7\u4e43\u57fa\u65bc\u816b\u7624ROR1 \u8868\u9054\uff0c\u6211\u5011\u5df2\u8b58\u5225\u514d\u75ab\u7d44\u7e54\u5316\u5b78\uff08IHC\uff09\u5019\u9078ROR1 \u6297\u9ad4\u514b\u9686\uff0c\u4ee5\u652f\u6301\u4f86\u6709\u95dc\u7cbe\u6e96\u6cbb\u7642\u85e5\u7269\u7684\u5de5\u4f5c\u3002
\nCS2006\uff08NM21-1480\u3001PD-L1\/4-1BB\/HSA\u4e09\u7279\u7570\u6027\u5206\u5b50\uff09
\u2013\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u9996\u6b21\u4eba\u9ad4\u8a66\u9a57\u6b63\u5728\u9032\u884c\uff0c\u7814\u7a76\u5730\u9ede\u5305\u62ec\u7f8e\u570b\u53ca\u4e2d\u570b\u53f0\u7063\u3002\u8a72\u7814\u7a76\u7684\u5291\u91cf\u905e\u589e\u90e8\u5206\u5df2\u5b8c\u6210\uff0c\u4e14\u8a72\u7814\u7a76\u5df2\u9032\u5165\u6982\u5ff5\u9a57\u8b49\u968e\u6bb5\u4ee5\u9032\u4e00\u6b65\u63a2\u7a76 CS2006 \u5728\u7279\u5b9a\u816b\u7624\u9069\u61c9\u75c7\u4e2d\u7684\u5b89\u5168\u6027\u53ca\u6709\u6548\u6027\u3002\u5291\u91cf\u905e\u589e\u7814\u7a76\u6578\u64da\u8a08\u5283\u65bc\u4eca\u5e74\u4e0b\u534a\u5e74\u516c\u4f48\u3002\u6211\u5011\u57282021\u5e74\u4e5d\u6708\u7372\u5f97\u570b\u5bb6\u85e5\u76e3\u5c40\u7684IND\u6279\u51c6\u3002\u6211\u5011\u57282022\u5e74AACR\u5e74\u6703\u516c\u4f48\u81e8\u5e8a\u524d\u6578\u64da\u3002 <\/p>\n

III.\u5229\u7528\u751f\u7269\u88fd\u54c1\u6a21\u584a\u5316\u6f5b\u529b\u63a8\u9032\u7814\u767c\u4e26\u52a0\u5f37\u6838\u5fc3\u816b\u7624\u514d\u75ab\u6cbb\u7642\u9818\u57df<\/p>\n

\u7cbe\u6e96\u6cbb\u7642\u85e5\u7269\u53ca\u514d\u75ab\u816b\u7624\u85e5\u7269\u806f\u5408\u6cbb\u7642\u4ecd\u7136\u662f\u6211\u5011\u7684\u6230\u7565\u91cd\u9ede\u3002\u5c07\u7d30\u80de\u6bd2\u6027\u85e5\u7269\u7cbe\u78ba\u5730\u8f38\u9001\u5230\u816b\u7624\u7684\u6297\u9ad4\u5076\u806f\u85e5\u7269\uff0c\u4ee5\u53ca\u53ef\u5275\u9020\u65b0\u751f\u7269\u5b78\u4e14\u81ea\u8eab\u7d44\u5408\u7684\u591a\u7279\u7570\u6027\u751f\u7269\u88fd\u54c1\u4ee3\u8868\u5169\u7a2e\u65e9\u671f\u958b\u767c\u7684\u77ed\u671f\u6a21\u5f0f\u3002<\/p>\n

\u57fa\u65bc\u6211\u5011\u7684\u300c\u6307\u74b0\u4e0a\u7684\u5bf6\u77f3\u300d\u7814\u767c\u7b56\u7565\uff0c\u6211\u5011\u7684\u7814\u767c\u5718\u968a\u6301\u7e8c\u63a8\u9032\u65e9\u671f\u5275\u65b0\u9805\u76ee\u3002\u8a72\u7b56\u7565\u5c07\u5229\u7528\u6a21\u584a\u300c\u5373\u88dd\u5373\u7528\u300d\u7684\u751f\u7269\u7279\u7570\u6027\u3002\u6839\u64da\u8a72\u7814\u767c\u6846\u67b6\uff0c\u6211\u5011\u64c1\u6709\u5171\u8d85\u904e10 \u500b\u6b63\u5728\u9032\u884c\u7684\u767c\u73fe\u968e\u6bb5\u9805\u76ee\u53ca\u9810\u671f\u65bc\u672c\u5e74\u5ea6\u5167\u5c07\u6709\u5169\u500b\u6f5b\u5728\u540c\u985e\u9996\u5275\/\u540c\u985e\u6700\u512a\u514d\u75ab\u816b\u7624\u9805\u76ee\u5ba3\u4f48\u70ba\u81e8\u5e8a\u524d\u5019\u9078\u85e5\u7269\u3002\u6b64\u5916\uff0c\u6211\u5011\u5728\u9776\u5411\u96e3\u6cbb\u6027\u7d30\u80de\u5167\u86cb\u767d\u7684\u5c08\u6709\u7d30\u80de\u7a7f\u900f\u6cbb\u7642\u5e73\u53f0\u4e0a\u53d6\u5f97\u91cd\u5927\u9032\u5c55\uff0c\u901a\u904e\u5c08\u6709\u7d30\u80de\u7a7f\u900f\u6cbb\u7642\u5e73\u53f0\u904b\u7528\u7684\u4e00\u7a2e\u6cbb\u7642\u6a21\u5f0f\u5be6\u73fe\u9ad4\u5916\u6982\u5ff5\u9a57\u8b49\u3002\u6211\u5011\u5df2\u5efa\u7acb\u5229\u7528\u81e8\u5e8a\u89c0\u5bdf\u53ca\u8f49\u5316\u77e5\u8b58\u63a8\u52d5\u767c\u73fe\u7684\u53ef\u6301\u7e8c\u5275\u65b0\u7814\u7a76\u5f15\u64ce\uff0c\u4e26\u5c07\u7e7c\u7e8c\u901a\u904e\u5728\u6211\u5011\u4f4d\u65bc\u4e2d\u570b\u8607\u5dde\u7684\u5168\u7403\u65b0\u7814\u767c\u4e2d\u5fc3\u7684\u81ea\u4e3b\u7814\u7a76\u4ee5\u53ca\u8207\u6211\u5011\u696d\u52d9\u5408\u4f5c\u5925\u4f34\u7684\u5408\u4f5c\u52a0\u5f37\u6211\u5011\u7372\u53d6\u5275\u65b0\u7684\u6a21\u5f0f\u3002\u9019\u4e9b\u8209\u63aa\u978f\u56fa\u4e86\u6211\u5011\u5728\u514d\u75ab\u816b\u7624\u6cbb\u7642\u53ca\u7cbe\u6e96\u6cbb\u7642\u9818\u57df\u7684\u512a\u52e2\uff0c\u4e26\u589e\u5f37\u4e86\u6211\u5011\u5be6\u73fe\u6bcf\u5e74\u63d0\u4ea41\u81f32\u500bIND\u7684\u9577\u671f\u76ee\u6a19\u7684\u80fd\u529b\u3002<\/p>\n

\u5e74\u521d\u81f3\u4eca\uff0c\u6211\u5011\u5df2\u65bc\u82e5\u5e72\u8209\u63aa\u4e2d\u53d6\u5f97\u91cd\u5927\u9032\u5c55\uff1a<\/p>\n

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\u8212\u683c\u5229\u55ae\u6297\uff1a2022\u5e74\u7b2c\u56db\u5b63\u5ea6\u62162023\u5e74\u7b2c\u4e00\u5b63\u5ea6\u767c\u4f48\u7528\u65bc\u4e00\u7dda\u6cbb\u7642\u8f49\u79fb\u6027\u80c3\u817a\u764c\/\u80c3\u98df\u7ba1\u7d50\u5408\u90e8\u817a\u764cIII\u671f\u8a66\u9a57\u4e3b\u8981\u7814\u7a76\u7d50\u679c\u3002 \u8212\u683c\u5229\u55ae\u6297\uff1a2022\u5e74\u7b2c\u56db\u5b63\u5ea6\u62162023\u5e74\u7b2c\u4e00\u5b63\u5ea6\u767c\u4f48\u7528\u65bc\u4e00\u7dda\u6cbb\u7642\u8f49\u79fb\u6027\u98df\u7ba1\u9c57\u764cIII\u671f\u8a66\u9a57\u7684\u4e3b\u8981\u7814\u7a76\u7d50\u679c\u3002 \u8212\u683c\u5229\u55ae\u6297\uff1a2023\u5e74\u4e0a\u534a\u5e74\u767c\u4f48III\u671fNSCLC\u7684III\u671f\u8a66\u9a57OS\u4e2d\u671f\u5206\u6790\u4e3b\u8981\u7814\u7a76\u7d50\u679c\u3002 Nofazinlimab\uff1a2023\u5e74\u4e0a\u534a\u5e74\u767c\u4f48nofazinlimab\u806f\u5408 LENVIMA\u00ae (lenvatinib)\u4e00\u7dda\u6cbb\u7642\u665a\u671fHCC\u60a3\u8005III\u671f\u5168\u7403\u8a66\u9a57\u4e3b\u8981\u7814\u7a76\u7d50\u679c\u3002 <\/p>\n

\u65e9\u671f\u81e8\u5e8a\u9805\u76ee\uff1a<\/p>\n

CS2006\uff1a\u5728\u9078\u5b9a\u5be6\u9ad4\u7624\u9069\u61c9\u75c7\u4e2d\u555f\u52d5CS2006\u55ae\u85e5\u5291\u91cf\u7684\u6982\u5ff5\u9a57\u8b49\u64f4\u5c55\u968a\u5217\u53ca\u516c\u4f48\u5291\u91cf\u905e\u589e\u6578\u64da\u3002 <\/p>\n

\u7814\u7a76\u9805\u76ee\uff1a<\/p>\n

\u5c07\u767c\u73fe\u968e\u6bb5\u9805\u76ee\u4e2d\u76841 \u81f32 \u500b\u540c\u985e\u9996\u5275\/\u540c\u985e\u6700\u512a\u514d\u75ab\u816b\u7624\u9805\u76ee\u63a8\u9032\u81f3\u81e8\u5e8a\u524d\u958b\u767c\u3002 \u7372\u53d6\u5177\u6709\u4e00\u7a2e\u6216\u591a\u7a2e\u6cbb\u7642\u6a21\u5f0f\u7684\u5c08\u6709\u7d30\u80de\u7a7f\u900f\u6cbb\u7642\u5e73\u53f0\u7684\u9ad4\u5916\/\u9ad4\u5167\u6982\u5ff5\u9a57\u8b49\u3002 <\/p>\n

\u751f\u7522<\/p>\n

\u555f\u52d5\u8a66\u904b\u884c\u5f8c\uff0c\u6211\u5011\u65bc\u672c\u5e74\u5ea6\u6b63\u5728\u70ba\u5546\u696d\u898f\u6a21\u7684\u751f\u7522\u505a\u7c4c\u5099\uff0c\u7121\u8ad6\u662f\u7528\u65bc\u81e8\u5e8a\u8a66\u9a57\u6216\u662f\u7528\u65bc\u5546\u696d\u92b7\u552e\uff0c\u9019\u5c07\u4f7f\u6211\u5011\u6709\u80fd\u529b\u63a7\u5236\u81ea\u8eab\u7522\u54c1\u7684\u4f9b\u61c9\u3002\u8a72\u751f\u7522\u57fa\u5730\u5177\u5099\u751f\u752226,000 \u5347\u751f\u7269\u5236\u5291\u53ca10 \u5104\u5c0f\u5206\u5b50\u85e5\u7247\u7684\u80fd\u529b\u3002\u65bc\u672a\u4f86\u5341\u4e8c\u500b\u6708\uff0c\u6211\u5011\u5c07\u7e7c\u7e8c\u9032\u884c\u591a\u6b3e\u7522\u54c1\u7684\u6280\u8853\u8f49\u79fb\uff0c\u5f9e\u800c\u964d\u4f4e\u6210\u672c\uff0c\u63d0\u9ad8\u7522\u54c1\u7684\u9577\u671f\u76c8\u5229\u80fd\u529b\u3002<\/p>\n

\u5c55\u671b\u4e8c\u96f6\u4e8c\u4e8c\u5e74\u4ee5\u5f8c<\/p>\n

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\u6211\u5011\u7684\u81e8\u5e8a\u5718\u968a\u6b63\u5728\u901a\u904e\u6709\u6548\u7684\u9069\u61c9\u75c7\u64f4\u5c55\u53ca\u5730\u57df\u8986\u84cb\u64f4\u5927\u6211\u5011\u5546\u696d\u5316\u85e5\u7269\u7d44\u5408\u53ca\u5176\u53ef\u89f8\u9054\u7684\u6f5b\u5728\u5e02\u5834\u3002\u56e0\u6b64\uff0c\u6211\u5011\u6709\u671b\u5728\u4e00\u4e9b\u6700\u70ba\u5e38\u898b\u7684\u764c\u75c7\u9818\u57df\u5efa\u7acb\u7af6\u722d\u512a\u52e2\u3002<\/p>\n

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\u6211\u5011\u7684\u5546\u52d9\u62d3\u5c55\u5de5\u4f5c\u65e8\u5728\u901a\u904e\u6230\u7565\u5408\u4f5c\u95dc\u4fc2\u53ca\u4ea4\u6613\u5168\u9762\u91cb\u653e\u57fa\u77f3\u85e5\u696d\u7684\u696d\u52d9\u50f9\u503c\u3002\u7531\u65bc\u5176\u9818\u5c0e\u5c64\u3001\u7814\u7a76\u53ca\u8a55\u4f30\u5718\u968a\u4f4d\u65bc\u7f8e\u570b\uff0c\u4f7f\u5176\u5c0d\u6700\u6709\u767c\u5c55\u6f5b\u529b\u7684\u816b\u7624\u85e5\u7269\u5275\u65b0\u5177\u6709\u6e05\u6670\u6d1e\u898b\uff0c\u4e26\u4e14\u53ef\u66f4\u70ba\u76f4\u63a5\u5730\u7372\u5f97\u8cc7\u7522\u53ca\u5efa\u7acb\u6230\u7565\u5408\u4f5c\u5925\u4f34\u3002\u6211\u5011\u7684\u6230\u7565\u5c07\u7e7c\u7e8c\u4ee5\u7ba1\u7dda\u5efa\u8a2d\u4ea4\u6613\u70ba\u4e2d\u5fc3\uff0c\u91cd\u9ede\u95dc\u6ce8\u5177\u6709\u5168\u7403\u6b0a\u5229\u7684\u540c\u985e\u9996\u5275\u6216\u540c\u985e\u6700\u4f73\u8cc7\u7522\u3002\u540c\u6a23\u91cd\u8981\u7684\u662f\uff0c\u76f8\u8f03\u65bc\u55ae\u4e00\u6388\u6b0a\u8cc7\u7522\uff0c\u6211\u5011\u5c07\u512a\u5148\u8003\u616e\u591a\u7dad\u5ea6\u5408\u4f5c\u53ca\u7522\u54c1\u7d44\u5408\u4ea4\u6613\uff0c\u540c\u6642\u4fdd\u6301\u5177\u6709\u9ad8\u81e8\u5e8a\u53ca\u5546\u696d\u50f9\u503c\u7684\u8cc7\u7522\u7684\u9748\u6d3b\u5ea6\u3002\u6b64\u5916\uff0c\u5546\u52d9\u62d3\u5c55\u4e5f\u5c07\u767c\u63ee\u95dc\u9375\u4f5c\u7528\uff0c\u901a\u904e\u5168\u7403\u767c\u5c55\u53ca\u5546\u696d\u5408\u4f5c\u95dc\u4fc2\u4f7f\u6211\u5011\u7684\u8cc7\u7522\u50f9\u503c\u6700\u5927\u5316\u3002<\/p>\n

\u8ca1\u52d9\u6458\u8981<\/p>\n

\u570b\u969b\u8ca1\u52d9\u5831\u544a\u6e96\u5247\u8a08\u91cf\uff1a<\/p>\n

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2022\u5e743\u6708\uff0c\u570b\u5bb6\u85e5\u76e3\u5c40\u6279\u51c6\u5176\u7528\u65bc\u6cbb\u7642\u665a\u671f\u6216\u8f49\u79fb\u6027RET\u7a81\u8b8aMTC\u53caRET\u878d\u5408\u967d\u6027TC\u60a3\u8005\u7684\u9069\u61c9\u75c7\u3002\u2013\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 2022\u5e747\u6708\uff0c\u9999\u6e2f\u885b\u751f\u7f72\u6279\u51c6\u5176\u7528\u65bc\u6cbb\u7642\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027RET\u878d\u5408\u967d\u6027NSCLC\u60a3\u8005\u7684\u4e0a\u5e02\u7533\u8acb\u3002\u2013\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 2022\u5e742\u6708\uff0c\u4e2d\u570b\u53f0\u7063\u98df\u54c1\u85e5\u7269\u7ba1\u7406\u7f72\uff08TFDA\uff09\u53d7\u7406\u4e86\u5176\u7528\u65bc\u6cbb\u7642\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027RET\u878d\u5408\u967d\u6027NSCLC\u3001RET\u7a81\u8b8aMTC\u53ca RET\u878d\u5408\u967d\u6027TC\u60a3\u8005\u7684NDA\u3002 \u827e\u4f0f\u5c3c\u5e03\uff08CS3010\uff0cIDH1\u6291\u5236\u5291\uff09\uff0d\u6211\u5011\u5df2\u5c31\u8a72\u7522\u54c1\u53d6\u5f97\u9996\u500bNDA\u6279\u51c6\u3002\u2013\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 2022\u5e741\u6708\uff0c\u570b\u5bb6\u85e5\u76e3\u5c40\u6279\u51c6\u5176\u7528\u65bc\u6cbb\u7642\u651c\u5e36\u6709IDH1\u7a81\u8b8a\u7684R\/R AML\u6210\u4eba\u60a3\u8005\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\u3002 \u6d1b\u62c9\u66ff\u5c3c\uff08ROS-1\u6291\u5236\u5291\uff09\u2013\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u6211\u5011\u6b63\u8207\u8f1d\u745e\u5408\u4f5c\u5728\u5927\u4e2d\u83ef\u5340\u806f\u5408\u958b\u767c\u6d1b\u62c9\u66ff\u5c3c\uff0c\u7528\u65bc\u6cbb\u7642c-ros oncogene 1\uff08ROS1\uff09\u967d\u6027\u665a\u671fNSCLC\u30022022\u5e745\u6708\uff0c\u6d1b\u62c9\u66ff\u5c3c\u91dd\u5c0d\u6cbb\u7642ROS1 \u967d\u6027\u665a\u671fNSCLC\u7684\u95dc\u9375\u7814\u7a76\u5be6\u73fe\u9996\u4f8b\u60a3\u8005\u5165\u7d44\uff0c\u60a3\u8005\u7e7c\u7e8c\u4ee5\u7a69\u5b9a\u6b65\u4f10\u5165\u7d44\u3002 CS5001 (LCB71\uff0cROR1 ADC)\u2013\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u7372\u5f97\u7f8e\u570bFDA\u7684IND\u7533\u8acb\u6279\u51c6\u53ca\u6fb3\u5927\u5229\u4e9e\u502b\u7406\u59d4\u54e1\u6703\uff08\u300cEC\u300d\uff09\u6279\u51c6\u5f8c\uff0c\u6211\u5011\u958b\u59cb\u5c0d\u8a72\u6f5b\u5728\u540c\u985e\u6700\u512aROR1 ADC\u9032\u884c\u9996\u6b21\u4eba\u9ad4\u8a66\u9a57\uff0c\u4e26\u8fc5\u901f\u63a8\u9032\u5230\u5291\u91cf\u905e\u589e\u90e8\u5206\u7684\u60a3\u8005\u62db\u52df\u968e\u6bb5\u3002\u6b64\u5916\uff0c\u6211\u5011\u57282022\u5e743\u6708\u5411\u570b\u5bb6\u85e5\u76e3\u5c40\u63d0\u4ea4IND\u7533\u8acb\uff0c\u4e262022\u5e745\u6708\u7372\u5f97\u6279\u51c6\u3002\u70ba\u78ba\u4fdd\u751f\u7269\u6a19\u8a18\u7269\u9a45\u52d5\u60a3\u8005\u7684\u9078\u64c7\u4e43\u57fa\u65bc\u816b\u7624ROR1 \u8868\u9054\uff0c\u6211\u5011\u5df2\u8b58\u5225\u514d\u75ab\u7d44\u7e54\u5316\u5b78\uff08IHC\uff09\u5019\u9078ROR1 \u6297\u9ad4\u514b\u9686\uff0c\u4ee5\u652f\u6301\u4f86\u6709\u95dc\u7cbe\u6e96\u6cbb\u7642\u85e5\u7269\u7684\u5de5\u4f5c\u3002 CS2006\uff08NM21-1480\u3001PD-L1\/4-1BB\/HSA\u4e09\u7279\u7570\u6027\u5206\u5b50\uff09\u2013\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u9996\u6b21\u4eba\u9ad4\u8a66\u9a57\u6b63\u5728\u9032\u884c\uff0c\u7814\u7a76\u5730\u9ede\u5305\u62ec\u7f8e\u570b\u53ca\u4e2d\u570b\u53f0\u7063\u3002\u8a72\u7814\u7a76\u7684\u5291\u91cf\u905e\u589e\u90e8\u5206\u5df2\u5b8c\u6210\uff0c\u4e14\u8a72\u7814\u7a76\u5df2\u9032\u5165\u6982\u5ff5\u9a57\u8b49\u968e\u6bb5\u4ee5\u9032\u4e00\u6b65\u63a2\u7a76 CS2006 \u5728\u7279\u5b9a\u816b\u7624\u9069\u61c9\u75c7\u4e2d\u7684\u5b89\u5168\u6027\u53ca\u6709\u6548\u6027\u3002\u5291\u91cf\u905e\u589e\u7814\u7a76\u6578\u64da\u8a08\u5283\u65bc\u4eca\u5e74\u4e0b\u534a\u5e74\u516c\u4f48\u3002\u6211\u5011\u57282021\u5e74\u4e5d\u6708\u7372\u5f97\u570b\u5bb6\u85e5\u76e3\u5c40\u7684IND\u6279\u51c6\u3002\u6211\u5011\u57282022\u5e74AACR\u5e74\u6703\u516c\u4f48\u81e8\u5e8a\u524d\u6578\u64da\u3002 III.\u5229\u7528\u751f\u7269\u88fd\u54c1\u6a21\u584a\u5316\u6f5b\u529b\u63a8\u9032\u7814\u767c\u4e26\u52a0\u5f37\u6838\u5fc3\u816b\u7624\u514d\u75ab\u6cbb\u7642\u9818\u57df 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