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CI\uff0c0.32\u20130.61\uff1bP&lt;0.001\uff09\u3002   \u5728\u90e8\u5206\u7de9\u89e3\u7d44\u4e2d\uff0c\u5c3c\u62c9\u5e15\u5229\u7684\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\u70ba19.3\u500b\u6708\uff0c\u800c\u5b89\u6170\u5291\u7d44\u70ba8.3\u500b\u6708\uff08HR=0.45\uff1b95% CI\uff0c0.23\u20130.86\uff1bP=0.014\uff09\u3002   \u5c3c\u62c9\u5e15\u5229\u7684\u5b89\u5168\u6027\u8207\u4e4b\u524d\u7684\u81e8\u5e8a\u7814\u7a76\u4e00\u81f4\uff0c\u5728\u8a72\u4e9e\u7d44\u5206\u6790\u4e2d\u672a\u767c\u73fe\u65b0\u7684\u5b89\u5168\u6027\u554f\u984c\u3002  <\/p>\n<p>\u816b\u7624\u96fb\u5834\u6cbb\u7642<\/p>\n<p>\u816b\u7624\u96fb\u5834\u6cbb\u7642\u662f\u4e00\u7a2e\u5e72\u64fe\u816b\u7624\u7d30\u80de\u5206\u88c2\u7684\u96fb\u5834\u7642\u6cd5\u3002\u816b\u7624\u96fb\u5834\u6cbb\u7642\u8a2d\u5099\u611b\u666e\u76fe\u548cOptune Lua\uff0c\u5df2\u5728\u4e00\u4e9b\u570b\u5bb6\u548c\u5730\u5340\u7372\u6279\u6216\u4e0a\u5e02\u7528\u65bc\u6cbb\u7642\u65b0\u8a3a\u65b7\u53ca\u5fa9\u767c\u81a0\u8cea\u6bcd\u7d30\u80de\u7624\u53ca\u60e1\u6027\u80f8\u819c\u9593\u76ae\u7624\u3002<\/p>\n<p>\u8fd1\u671f\u7522\u54c1\u4eae\u9ede\uff1a<\/p>\n<p>2022\u5e746\u6708\uff0c\u518d\u9f0e\u91ab\u85e5\u548cNovocure\u5ba3\u4f482\u671f\u521d\u6b65\u81e8\u5e8a\u7814\u7a76EF-31\u9054\u5230\u4e86\u4e3b\u8981\u7814\u7a76\u7d42\u9ede\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\uff0c\u6b21\u8981\u7814\u7a76\u7d42\u9ede\u4e5f\u986f\u793a\u7a4d\u6975\u4fe1\u865f\u3002\u8a72\u7814\u7a76\u65e8\u5728\u8a55\u4f30\u816b\u7624\u96fb\u5834\u6cbb\u7642\uff08TTFields\uff09\u806f\u5408\u6a19\u6e96\u6cbb\u7642\uff08\u5316\u7642\u55ae\u85e5\u6216\u806f\u5408\u66f2\u59a5\u73e0\u55ae\u6297\u7528\u65bc\u6cbb\u7642HER2\u967d\u6027\u60a3\u8005\uff09\u4f5c\u70ba\u80c3\u764c\u4e00\u7dda\u6cbb\u7642\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002<\/p>\n<p>\u622a\u81f32022\u5e746\u670830\u65e5\uff0c\u611b\u666e\u76fe\u5df2\u88ab\u5217\u516550\u500b\u57ce\u5e02\u666e\u60e0\u96aa\u3002<\/p>\n<p>2022\u5e74\u9810\u671f\u91cc\u7a0b\u7891\uff1a<\/p>\n<p>\u9810\u8a08\u5b8c\u62103\u671f\u95dc\u9375\u81e8\u5e8a\u7814\u7a76METIS\u6700\u5f8c\u4e00\u4f4d\u60a3\u8005\u5165\u7d44\uff0c\u8a72\u7814\u7a76\u65e8\u5728\u8a55\u4f30\u7acb\u9ad4\u5b9a\u5411\u653e\u7642\u806f\u5408\u816b\u7624\u96fb\u5834\u6cbb\u7642\u5c0d\u6bd4\u55ae\u7368\u4f7f\u7528\u7acb\u9ad4\u5b9a\u5411\u653e\u7642\uff0c\u7528\u65bc\u6cbb\u7642\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u8166\u8f49\u79fb\u60a3\u8005\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002<\/p>\n<p>\u64ce\u6a02\u00ae\uff08\u745e\u6d3e\u66ff\u5c3c\uff09<\/p>\n<p>\u64ce\u6a02\u662f\u4e00\u6b3e\u958b\u95dc\u63a7\u5236\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff0c\u7d93\u8a2d\u8a08\u4ee5\u5ee3\u6cdb\u6291\u5236\u7a81\u8b8a\u7684KIT\u53caPDGFR\u03b1\u6fc0\u9176\uff0c\u662f\u76ee\u524d\u552f\u4e00\u5728\u7f8e\u570b\u548c\u4e2d\u570b\u7372\u6279\u7528\u65bc\u6cbb\u7642\u6240\u6709\u66fe\u63a5\u53d7\u904e\u4e09\u7a2e\u6216\u4ee5\u4e0a\u6fc0\u9176\u6291\u5236\u5291\u6cbb\u7642\u7684\u665a\u671f\u80c3\u8178\u9593\u8cea\u7624\uff08GIST\uff09\u60a3\u8005\u7684\u7642\u6cd5\u3002<\/p>\n<p>\u8fd1\u671f\u7522\u54c1\u4eae\u9ede\uff1a<\/p>\n<p>\u622a\u81f32022\u5e746\u670830\u65e5\uff0c\u81ea2021\u5e745\u6708\u5728\u4e2d\u570b\u5167\u5730\u5546\u696d\u4e0a\u5e02\u4ee5\u4f86\uff0c\u64ce\u6a02\u5df2\u88ab\u5217\u516573\u500b\u57ce\u5e02\u666e\u60e0\u96aa\u3002<\/p>\n<p>2022\u5e74\u9810\u671f\u91cc\u7a0b\u7891\uff1a<\/p>\n<p>\u722d\u53d6\u5c07\u64ce\u6a02\u7528\u65bc\u56db\u7dda\u80c3\u8178\u9593\u8cea\u7624\u6cbb\u7642\u7684\u9069\u61c9\u8b49\u7d0d\u5165\u570b\u5bb6\u91ab\u4fdd\u85e5\u54c1\u76ee\u9304\uff08NRDL\uff09\u3002<\/p>\n<p>Adagrasib<\/p>\n<p>Adagrasib\u662f\u4e00\u6b3e\u9ad8\u9078\u64c7\u6027\u7684\u5f37\u6548\u53e3\u670d\u5c0f\u5206\u5b50KRASG12C\u6291\u5236\u5291\uff0c\u7528\u65bc\u6cbb\u7642KRASG12C\u7a81\u8b8a\u7684\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u3001\u7d50\u76f4\u8178\u764c\uff08CRC\uff09\u3001\u80f0\u817a\u764c\u548c\u5176\u4ed6\u5be6\u9ad4\u7624\u3002<\/p>\n<p>\u8fd1\u671f\u7522\u54c1\u4eae\u9ede\uff1a<\/p>\n<p>2022\u5e747\u6708\uff0c\u518d\u9f0e\u91ab\u85e5\u5b8c\u6210\u5168\u74033\u671f\u81e8\u5e8a\u7814\u7a76KRYSTAL-12\u5927\u4e2d\u83ef\u5340\u9996\u4f4d\u60a3\u8005\u7d66\u85e5\uff0c\u8a72\u7814\u7a76\u65e8\u5728\u8a55\u4f30adagrasib\u7528\u65bcKRASG12C\u7a81\u8b8a\u7684\u665a\u671fNSCLC\u60a3\u8005\u7684\u6cbb\u7642\u3002<\/p>\n<p>2022\u5e746\u6708\uff0c\u518d\u9f0e\u91ab\u85e5\u5b8c\u6210\u5168\u74033\u671f\u81e8\u5e8a\u7814\u7a76KRYSTAL-10\u5927\u4e2d\u83ef\u5340\u9996\u4f4d\u60a3\u8005\u7d66\u85e5\uff0c\u8a72\u7814\u7a76\u65e8\u5728\u8a55\u4f30adagrasib\u806f\u5408\u897f\u59a5\u6614\u55ae\u6297\u7528\u65bcKRASG12C\u7a81\u8b8a\u7684\u665a\u671fCRC\u60a3\u8005\u7684\u6cbb\u7642\u3002<\/p>\n<p>2022\u5e746\u6708\uff0c\u518d\u9f0e\u91ab\u85e5\u5408\u4f5c\u5925\u4f34Mirati Therapeutics, Inc.\uff08Mirati\uff09\u57282022\u5e74ASCO\u5e74\u6703\u4e0a\u516c\u4f48\u4e86\u4ee5\u4e0b\u4fe1\u606f\uff1a<\/p>\n<p>Mirati\u5831\u544a\u4e862\u671f\u8a3b\u518a\u6027\u81e8\u5e8a\u7814\u7a76KRYSTAL-1\u7684\u5b8c\u6574\u7d50\u679c\uff0c\u8a72\u7814\u7a76\u65e8\u5728\u8a55\u4f30adagrasib\u7528\u65bc\u7d93\u6cbb\u7684\u5177\u6709KRASG12C\u7a81\u8b8a\u7684NSCLC\u60a3\u8005\uff0c\u76f8\u95dc\u7d50\u679c\u540c\u6642\u767c\u8868\u5728\u300a\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u96dc\u8a8c\u300b\u4e0a\u3002\u8a72\u7d50\u679c\u5305\u62ec\u4f86\u81ea2\u671fKRYSTAL-1\u7814\u7a76\u7684NSCLC\u968a\u5217\u7684\u56de\u9867\u6027\u4e9e\u7d44\u5206\u6790\u7d50\u679c\uff0c\u8a72\u7814\u7a76\u65e8\u5728\u8a55\u4f30adagrasib\u7528\u65bc\u5177\u6709KRASG12C\u7a81\u8b8a\u7684NSCLC\u60a3\u8005\u548c\u7a69\u5b9a\u7684\u3001\u7d93\u6cbb\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u8f49\u79fb\u7684\u60a3\u8005\u3002<br \/>\n2\u671f\u8a3b\u518a\u6027\u81e8\u5e8a\u7814\u7a76\u7684\u7d50\u679c\u7d9c\u8ff0\uff08n=112\uff09\uff1a\u521d\u6b65\u7d50\u679c\u986f\u793a\u5ba2\u89c0\u7de9\u89e3\u7387\u70ba43%\uff0c\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u70ba80%\uff0c\u4e2d\u4f4d\u7de9\u89e3\u6301\u7e8c\u6642\u9593\uff08mDOR\uff09\u70ba8.5\u500b\u6708\uff0895% CI\uff1a6.2\u201313.8\uff09\uff0cmPFS\u70ba6.5\u500b\u6708\uff0895% CI\uff1a4.7\u20138.4\uff09\u3002\u622a\u81f32022\u5e741\u670815\u65e5\u7684\u6578\u64da\u986f\u793a\uff0c\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\uff08mOS\uff09\u70ba12.6\u500b\u6708\uff0895% CI\uff1a9.2\u201319.2\uff09\u3002    \u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\uff08CNS\uff09\u7279\u7570\u6027\u6d3b\u6027\uff08n=33\uff09\u5728\u7a69\u5b9a\u7684\u3001\u7d93\u6cbb\u7684CNS\u8f49\u79fb\u7076\u5b50\u96c6\u4e2d\u9032\u884c\u4e86\u8a55\u4f30\uff1a\u7d50\u679c\u986f\u793a\u9871\u5167\uff08IC\uff09\u5ba2\u89c0\u7de9\u89e3\u7387\u70ba33%\uff0811\/33\uff09\u3002<br \/>\n\u6b64\u5916\uff0cMirati\u5831\u544a\u4e86KRYSTAL-1\u7814\u7a76\u532f\u7e3d\u5206\u6790\u7684\u6700\u65b0\u7d50\u679c\uff0c\u5305\u62ec\u8a3b\u518a\u60272\u671f\u548c1\/1b\u671fNSCLC\u968a\u5217\u3002<br \/>\nKRYSTAL-1 NSCLC\u968a\u5217\uff08n=132\uff09\u7684\u532f\u7e3d\u5206\u6790\uff1a\u521d\u6b65\u7d50\u679c\u986f\u793aORR\u70ba44%\uff0cDCR\u70ba81%\u3002mDOR\u70ba12.5\u500b\u6708\uff0cmPFS\u70ba6.9\u500b\u6708\u3002\u622a\u81f32022\u5e741\u670815\u65e5\u7684\u6578\u64da\u986f\u793a\uff0cmOS\u70ba14.1\u500b\u6708\u3002   <\/p>\n<p>2022\u5e746\u6708\uff0cMirati\u9084\u516c\u4f48\u4e86KRYSTAL-1\u7814\u7a761b\u671f\u968a\u5217\u7684\u524d\u77bb\u6027\u5206\u6790\u7d50\u679c\uff0c\u8a72\u7814\u7a76\u65e8\u5728\u8a55\u4f30adagrasib\u7528\u65bc\u5177\u6709KRASG12C\u7a81\u8b8a\u4e14\u4f34\u6709\u6d3b\u52d5\u6027\u548c\u521d\u6cbb\u7684CNS\u8f49\u79fb\u7684\u665a\u671fNSCLC\u60a3\u8005\u7684\u9871\u5167\u53cd\u61c9\u3002<\/p>\n<p>\u6d3b\u52d5\u6027\u548c\u521d\u6cbb\u7684CNS\u8f49\u79fb\u7076\u4e2d\u7684CNS\u7279\u7570\u6027\u6d3b\u6027(n=19)\uff1a\u7d50\u679c\u986f\u793a\u9871\u5167ORR\u70ba32%\uff086\/19\uff09\u3002  <\/p>\n<p>2022\u5e74\u9810\u671f\u91cc\u7a0b\u7891\uff1a<\/p>\n<p>\u65bc2022\u5e74\u7b2c\u56db\u5b63\u5ea6\u66f4\u65b02\u671f\u7814\u7a76KRYSTAL-7\u7684\u8010\u53d7\u6027\u548cORR\u6578\u64da\uff0c\u8a72\u7814\u7a76\u65e8\u5728\u8a55\u4f30adagrasib\u8207\u5e15\u535a\u5229\u73e0\u55ae\u6297\u806f\u5408\u7528\u65bc\u4e00\u7ddaKRASG12C\u7a81\u8b8a\u7684NSCLC\u6cbb\u7642\u3002<\/p>\n<p>\u9032\u4e00\u6b65\u660e\u78baadagrasib\u55ae\u85e5\u4e00\u7dda\u6cbb\u7642KRASG12C\u7a81\u8b8a\u7684NSCLC\u7684\u8a3b\u518a\u8def\u5f91\uff0c\u4ee5\u53ca\u91dd\u5c0dNSCLC\u4ee5\u5916\u7684\u7624\u7a2e\u7684\u4e0b\u4e00\u6b65\u8a08\u5283\u3002<\/p>\n<p>Adagrasib\u6709\u671b\u7372\u5f97FDA\uff08\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff09\u6279\u51c6\u4e26\u5546\u696d\u5316\u4e0a\u5e02\uff0c\u7528\u65bc\u6cbb\u7642\u66fe\u7d93\u63a5\u53d7\u904e\u81f3\u5c11\u4e00\u6b21\u7cfb\u7d71\u6027\u6cbb\u7642\u7684KRASG12C\u7a81\u8b8a\u7684NSCLC\u60a3\u8005\uff1b\u8655\u65b9\u85e5\u7528\u6236\u4ed8\u8cbb\u6cd5\u6848\uff08PDUFA\uff09\u7684\u76ee\u6a19\u884c\u52d5\u65e5\u671f\u70ba2022\u5e7412\u670814\u65e5\u3002<\/p>\n<p>Bemarituzumab<\/p>\n<p>Bemarituzumab\u662f\u4e00\u6b3e\u5177\u6709\u540c\u985e\u9996\u5275\u6f5b\u529b\u7684\u6297\u9ad4\uff0c\u4f5c\u70ba\u91dd\u5c0dFGFR2b\u904e\u5ea6\u8868\u9054\u7684\u816b\u7624\u9776\u5411\u7642\u6cd5\uff0c\u6b63\u5728\u9032\u884c\u91dd\u5c0d\u80c3\u764c\u53ca\u80c3\u98df\u7ba1\u4ea4\u754c\u90e8\uff08GEJ\uff09\u764c\u7684\u958b\u767c\u3002<\/p>\n<p>\u8fd1\u671f\u7522\u54c1\u4eae\u9ede\uff1a<\/p>\n<p>\u518d\u9f0e\u91ab\u85e5\u5408\u4f5c\u5925\u4f34\u5b89\u9032\u5831\u544a\uff0c2\u671f\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5c0d\u7167\u7814\u7a76FIGHT\u7684\u6700\u7d42\u5206\u6790\u5df2\u7d93\u5b8c\u6210\uff0c\u8a72\u9805\u7814\u7a76\u65e8\u5728\u8a55\u4f30bemarituzumab\u806f\u5408\u6539\u826f\u7684FOLFOX6\uff08mFOLFOX6\uff09\u7528\u65bc\u521d\u6cbb\u7684\u665a\u671f\u80c3\u764c\u548c\u80c3\u98df\u7ba1\u4ea4\u754c\u90e8\u764c\u60a3\u8005\u3002\u9019\u4e9b\u7d50\u679c\u7e7c\u7e8c\u8b49\u660ebemarituzumab\u806f\u5408mFOLFOX6\u6539\u5584\u4e86\u8868\u9054FGFR2b\u7684\u816b\u7624\u60a3\u8005\u7684\u81e8\u5e8a\u7d50\u679c\uff0c\u6c92\u6709\u65b0\u7684\u5b89\u5168\u6027\u554f\u984c\u3002\u96a8\u8457FGFR2b\u8868\u9054\u6c34\u5e73\u7684\u589e\u52a0\uff0c\u89c0\u5bdf\u5230\u66f4\u5927\u7684\u751f\u5b58\u7372\u76ca\u3002<\/p>\n<p>\u518d\u9f0e\u91ab\u85e5\u5408\u4f5c\u5925\u4f34\u5b89\u9032\u5df2\u7d93\u555f\u52d5\u4e86\u4e00\u98051b\/2\u671f\u7814\u7a76\uff08FORTITUDE-301\uff09\uff0c\u8a55\u4f30bemarituzumab\u55ae\u85e5\u7528\u65bcFGFR2b\u904e\u5ea6\u8868\u9054\u5be6\u9ad4\u7624\u7684\u5b89\u5168\u6027\u53ca\u7642\u6548\u3002<\/p>\n<p>2022\u5e74\u9810\u671f\u91cc\u7a0b\u7891\uff1a<\/p>\n<p>\u65bc2022\u5e74\u7b2c\u56db\u5b63\u5ea6\u5728\u5927\u4e2d\u83ef\u5340\u555f\u52d5\u4e00\u9805\u8a55\u4f30bemarituzumab\u7528\u65bc\u4e00\u7dda\u665a\u671f\u80c3\u764c\u548cGEJ\u764c\u6cbb\u7642\u7684\u8a3b\u518a\u6027\u7814\u7a76\u3002<\/p>\n<p>Odronextamab<\/p>\n<p>Odronextamab\u662f\u4e00\u6b3e\u96d9\u7279\u7570\u6027\u6297\u9ad4\uff0c\u65e8\u5728\u901a\u904e\u9023\u63a5\u4e26\u6d3b\u5316\u7d30\u80de\u6bd2\u6027T\u7d30\u80de\uff08\u8207CD3\u7d50\u5408\uff09\u53ca\u6dcb\u5df4\u7624\u7d30\u80de\uff08\u8207CD20\u7d50\u5408\uff09\uff0c\u89f8\u767c\u6297\u816b\u7624\u4f5c\u7528\u3002<\/p>\n<p>2022\u5e74\u9810\u671f\u91cc\u7a0b\u7891\uff1a<\/p>\n<p>\u5b8c\u6210B\u7d30\u80de\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08B-NHL\uff09\u6f5b\u5728\u95dc\u93752\u671f\u7814\u7a76\u7684\u5165\u7d44\u3002<\/p>\n<p>\u516c\u4f48\u7528\u65bcB-NHL\u6cbb\u7642\u7684\u6f5b\u5728\u95dc\u93752\u671f\u7814\u7a76\u7684\u9032\u4e00\u6b65\u7d50\u679c\uff0c\u4e26\u5411FDA\u63d0\u4ea4\u751f\u7269\u88fd\u54c1\u8a31\u53ef\u7533\u8acb\uff08BLA\uff09\u3002<\/p>\n<p>Repotrectinib<\/p>\n<p>Repotrectinib\u662f\u65b0\u4e00\u4ee3\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08TKI\uff09\uff0c\u80fd\u6709\u6548\u9776\u5411\u4f5c\u7528\u65bcROS1\u53caTRK \u00a0A\/B\/C\uff0c\u5c0d\u65e2\u5f80\u672a\u63a5\u53d7\u904eTKI\u6cbb\u7642\u6216TKI\u7d93\u6cbb\u7684\u60a3\u8005\u5747\u6709\u6cbb\u7642\u6f5b\u529b\u3002<\/p>\n<p>\u8fd1\u671f\u7522\u54c1\u4eae\u9ede\uff1a<\/p>\n<p>2022\u5e747\u6708\uff0c\u518d\u9f0e\u91ab\u85e5\u5408\u4f5c\u5925\u4f34Turning Point Therapeutics, Inc.\uff08Turning Point\uff09\u5ba3\u4f48\u5728\u7b2c\u4e8c\u5b63\u5ea6\u8209\u884c\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\uff08NDA\uff09\u524d\u6703\u8b70\u4e0a\u6536\u5230FDA\u7684\u7a4d\u6975\u53cd\u994b\u3002FDA\u540c\u610fTurning Point\u5728\u63d0\u4ea4\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\u6642\uff0c\u63d0\u4ea4ROS1\u967d\u6027\u7684TKI\u521d\u6cbb\u548cTKI\u7d93\u6cbb\u7684\u665a\u671fNSCLC\u60a3\u8005\u81ea\u7b2c\u4e00\u6b21\u57fa\u7dda\u5f8c\u6383\u7784\u958b\u59cb\u7684\u81f3\u5c11\u516d\u500b\u6708\u96a8\u8a2a\u6578\u64da\u7684\u8a08\u5283\u3002<\/p>\n<p>2022\u5e746\u6708\uff0c\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\u6388\u4e88repotrectinib\u5169\u9805\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\uff08BTD\uff09\uff0c\u7528\u65bc\u65e2\u5f80\u63a5\u53d7\u904e1\u500b\u524d\u7ddaROS1 TKI\u548c1\u500b\u524d\u7dda\u542b\u9251\u5316\u7642\u7684ROS1\u967d\u6027\u8f49\u79fb\u6027NSCLC\u60a3\u8005\uff0c\u4ee5\u53ca\u65e2\u5f80\u63a5\u53d7\u904e1\u500b\u524d\u7ddaROS1 TKI\u4e26\u4e14\u672a\u63a5\u53d7\u5316\u7642\u6216\u514d\u75ab\u6cbb\u7642\u7684ROS1\u967d\u6027\u8f49\u79fb\u6027NSCLC\u60a3\u8005\u3002<\/p>\n<p>2022\u5e745\u6708\uff0c\u518d\u9f0e\u91ab\u85e5\u548cTurning Point\u5ba3\u4f48FDA\u6388\u4e88repotrectinib\u7b2c\u516b\u500b\u8a3b\u518a\u8a8d\u5b9a\u66a8\u7b2c\u4e09\u500b\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\uff0c\u7528\u65bc\u6cbb\u7642\u6b64\u524d\u63a5\u53d7\u904e\u4e00\u7a2eROS1 TKI\u6cbb\u7642\u548c\u4e4b\u524d\u672a\u63a5\u53d7\u904e\u542b\u9251\u5316\u7642\u7684ROS1\u967d\u6027\u8f49\u79fb\u6027NSCLC\u60a3\u8005\u3002<\/p>\n<p>2022\u5e74\u9810\u671f\u91cc\u7a0b\u7891\uff1a<\/p>\n<p>\u5b8c\u62101\/2\u671f\u8a3b\u518a\u6027\u7814\u7a76TRIDENT-1\u6240\u6709\u968a\u5217\u7684\u60a3\u8005\u5165\u7d44\u3002<\/p>\n<p>\u9810\u8a08\u5728\u5373\u5c07\u53ec\u958b\u7684\u91ab\u5b78\u6703\u8b70\u4e0a\uff0c\u8a73\u7d30\u66f4\u65b0\u7d93BICR\u5206\u6790\u7684TRIDENT-1\u7684\u7814\u7a76\u7d50\u679c\uff0c\u5305\u62ec\u9871\u5167\u6d3b\u6027\u7684\u7814\u7a76\u7d50\u679c\u3002<\/p>\n<p>\u63d0\u4f9bTRIDENT-1\u7814\u7a76\u4e2dNTRK\u967d\u6027\u665a\u671f\u5be6\u9ad4\u7624\u968a\u5217\u7684\u81e8\u5e8a\u6578\u64da\u66f4\u65b0\u3002<\/p>\n<p>CLN-081<\/p>\n<p>CLN-081\u662f\u4e00\u6b3e\u53e3\u670d\u3001\u4e0d\u53ef\u9006\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\uff08EGFR\uff09\u6291\u5236\u5291\uff0c\u53ef\u4ee5\u9078\u64c7\u6027\u5730\u9776\u5411\u4f5c\u7528\u65bcEGFR\u5916\u986f\u5b5020\u63d2\u5165\u7a81\u8b8a\uff0c\u540c\u6642\u907f\u958b\u8868\u9054\u91ce\u751f\u578bEGFR\u7684\u7d30\u80de\u3002<\/p>\n<p>\u8fd1\u671f\u7522\u54c1\u4eae\u9ede\uff1a<\/p>\n<p>2022\u5e746\u6708\uff0c\u518d\u9f0e\u91ab\u85e5\u5408\u4f5c\u5925\u4f34Cullinan Oncology\u57282022\u5e74ASCO\u5e74\u6703\u4e0a\u516c\u4f48\u4e86\u91dd\u5c0dEGFR\u5916\u986f\u5b5020\u63d2\u5165\u7a81\u8b8a\u7684NSCLC\u60a3\u8005\u76841\/2a\u671f\u7814\u7a76\u7684\u66f4\u65b0\u6578\u64da\u3002\u5728100mg\u6bcf\u65e5\u5169\u6b21\u5291\u91cf\u7d44\u768439\u540d\u60a3\u8005\u4e2d\uff1a<\/p>\n<p>16\u540d\uff0841%\uff09\u60a3\u8005\u78ba\u5b9a\u90e8\u5206\u7de9\u89e3\u3002   \u9810\u4f30\u4e2d\u4f4d\u7de9\u89e3\u6301\u7e8c\u6642\u9593\u8d85\u904e21\u500b\u6708\u3002   \u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\u70ba12\u500b\u6708\u3002   CLN-081\u7684\u5b89\u5168\u6027\u4f7f\u5176\u53ef\u7528\u65bc\u9577\u671f\u6cbb\u7642\u3002  <\/p>\n<p>2022\u5e74\u9810\u671f\u91cc\u7a0b\u7891\uff1a<\/p>\n<p>\u5728\u5b8c\u6210\u98df\u7269\u6548\u61c9\u85e5\u4ee3\u52d5\u529b\u5b78\uff08PK\uff09\u7814\u7a76\u5f8c\uff0c\u555f\u52d5\u95dc\u9375\u6027\u7814\u7a76\u3002<\/p>\n<p>Elzovantinib (TPX-0022)<\/p>\n<p>Elzovantinib\u662f\u4e00\u6b3e\u53e3\u670d\u591a\u9776\u9ede\u6fc0\u9176\u6291\u5236\u5291\uff0c\u5177\u6709\u65b0\u578b\u4e09\u7dad\u5927\u74b0\u7d50\u69cb\uff0c\u53ef\u6291\u5236MET\u3001CSF1R\uff08\u96c6\u843d\u523a\u6fc0\u56e0\u5b501\u53d7\u9ad4\uff09\u53caSRC\u6fc0\u9176\u3002\u00a0<\/p>\n<p>2022\u5e74\u9810\u671f\u91cc\u7a0b\u7891\uff1a<\/p>\n<p>\u5168\u74031\/2\u671f\u81e8\u5e8a\u7814\u7a76SHIELD-1\u76841\u671f\u64f4\u5c55\u90e8\u5206\u5b8c\u6210\u5927\u4e2d\u83ef\u5340\u9996\u4f4d\u60a3\u8005\u5165\u7d44\u3002<\/p>\n<p>\u63d0\u4f9bSHIELD-1 1\u671f\u7814\u7a76\u7684\u81e8\u5e8a\u6578\u64da\u66f4\u65b0\u3002<\/p>\n<p>\u8996FDA\u5c0d\u4e2d\u7b49\u5291\u91cf\u6c34\u5e73\u6578\u64da\u7684\u53cd\u994b\u800c\u5b9a\uff0c\u555f\u52d5SHIELD-1\u81e8\u5e8a\u7814\u7a76\u76842\u671f\u90e8\u5206\u3002<\/p>\n<p>BLU-945<\/p>\n<p>BLU-945\u662f\u4e00\u6b3e\u8655\u65bc\u7814\u7a76\u968e\u6bb5\u7684\u9078\u64c7\u6027\u3001\u5f37\u6548\u7684EGFR\u6291\u5236\u5291\uff0c\u53ef\u4ee5\u6291\u5236L858R\u6d3b\u5316\u7a81\u8b8a\u621619\u5916\u986f\u5b50\u7f3a\u5931\u7a81\u8b8a\u4f34\u6709\u7372\u5f97\u6027T790M\u548cC797S\u7a81\u8b8a\uff0c\u9019\u4e9b\u7a81\u8b8a\u5206\u5225\u662f\u7b2c\u4e00\u4ee3EGFR\u6291\u5236\u5291\u548c\u5967\u5e0c\u66ff\u5c3c\u5e38\u898b\u7684\u9776\u5167\u8010\u85e5\u7a81\u8b8a\u3002BLU-945\u6709\u671b\u7528\u65bc\u6cbb\u7642EGFR\u9a45\u52d5\u7684\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u3002<\/p>\n<p>\u8fd1\u671f\u7522\u54c1\u4eae\u9ede\uff1a<\/p>\n<p>2022\u5e746\u6708\uff0c\u518d\u9f0e\u91ab\u85e5\u7372\u5f97\u4e86\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u5c0d\u5168\u74031\/2\u671f\u81e8\u5e8a\u7814\u7a76SYMPHONY\u4e2dBLU-945\u55ae\u85e5\u968a\u5217\u5728\u5927\u4e2d\u83ef\u5340\u7684\u81e8\u5e8a\u8a66\u9a57\u6279\u4ef6\u3002<\/p>\n<p>2022\u5e74\u9810\u671f\u91cc\u7a0b\u7891\uff1a<\/p>\n<p>\u516c\u4f48\u91dd\u5c0dEGFR\u7a81\u8b8aNSCLC\u60a3\u8005\u76841\/2\u671f\u81e8\u5e8a\u7814\u7a76SYMPHONY\u4e2d\u7684BLU-945\u55ae\u85e5\u6cbb\u7642\u7684\u66f4\u65b0\u6578\u64da\uff0c\u4ee5\u53ca\u8207\u5967\u5e0c\u66ff\u5c3c\u806f\u7528\u7684\u5291\u91cf\u905e\u589e\u968a\u5217\u7684\u521d\u6b65\u81e8\u5e8a\u6578\u64da\u3002<\/p>\n<p>\u57281\/2\u671f\u81e8\u5e8a\u7814\u7a76SYMPHONY\u4e2d\u555f\u52d5\u66f4\u591a\u968a\u5217\uff0c\u7528\u65bc\u8a55\u4f30BLU-945\u5728\u591a\u500b\u60a3\u8005\u4eba\u7fa4\u4e2d\u8207\u5176\u4ed6\u85e5\u7269\u806f\u7528\uff0c\u5305\u62ec\u524d\u7dda\u6cbb\u7642\u3002<\/p>\n<p>BLU-701<\/p>\n<p>BLU-701\u662f\u4e00\u6b3e\u8655\u65bc\u7814\u7a76\u968e\u6bb5\u7684\u9078\u64c7\u6027\u3001\u5f37\u6548\u7684EGFR\u6291\u5236\u5291\uff0c\u53ef\u4ee5\u6291\u5236L858R\u6d3b\u5316\u7a81\u8b8a\u621619\u5916\u986f\u5b50\u7f3a\u5931\u7a81\u8b8a\u4f34\u6709\u7372\u5f97\u6027C797S\u7a81\u8b8a\uff0c\u9019\u4e9b\u7a81\u8b8a\u662f\u5967\u5e0c\u66ff\u5c3c\u5e38\u898b\u7684\u9776\u5167\u8010\u85e5\u7a81\u8b8a\u3002BLU-701\u6709\u671b\u7528\u65bc\u6cbb\u7642EGFR\u9a45\u52d5\u7684\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u3002<\/p>\n<p>2022\u5e74\u9810\u671f\u91cc\u7a0b\u7891\uff1a<\/p>\n<p>\u516c\u4f48BLU-701\u6cbb\u7642EGFR\u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u76841\/2\u671f\u81e8\u5e8a\u7814\u7a76HARMONY\u7684\u521d\u6b65\u81e8\u5e8a\u6578\u64da\u3002<\/p>\n<p>\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u9818\u57df<\/p>\n<p>VYVGART\u00ae\uff08Efgartigimod\uff09<\/p>\n<p>Efgartigimod\u662f\u4e00\u6b3e\u6297\u9ad4\u7247\u6bb5\uff0c\u65e8\u5728\u6e1b\u5c11\u81f4\u75c5\u6027\u514d\u75ab\u7403\u86cb\u767dG\uff08IgG\uff09\u81ea\u8eab\u6297\u9ad4\u4e26\u963b\u65b7IgG\u5faa\u74b0\u5229\u7528\u904e\u7a0b\u3002\u5176\u8207\u65b0\u751f\u5152Fc\u53d7\u9ad4\uff08FcRn\uff09\u7d50\u5408\uff0c\u8a72\u53d7\u9ad4\u5728\u5168\u8eab\u90fd\u6709\u5ee3\u6cdb\u8868\u9054\uff0c\u5728\u963b\u6b62IgG\u964d\u89e3\u7684\u904e\u7a0b\u4e2d\u767c\u63ee\u8457\u6838\u5fc3\u4f5c\u7528\u3002<\/p>\n<p>\u8fd1\u671f\u7522\u54c1\u4eae\u9ede\uff1a<\/p>\n<p>2022\u5e747\u6708\uff0c\u518d\u9f0e\u91ab\u85e5\u5ba3\u4f48efgartigimod\u6ce8\u5c04\u6db2\u7528\u65bc\u6cbb\u7642\u6210\u4eba\u5168\u8eab\u578b\u91cd\u75c7\u808c\u7121\u529b\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\u7372\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u53d7\u7406\u3002<\/p>\n<p>2022\u5e746\u6708\uff0cefgartigimod\u843d\u5730\u6d77\u5357\u535a\u9c32\u6a02\u57ce\u570b\u969b\u91ab\u7642\u65c5\u904a\u5148\u884c\u5340\u30022022\u5e747\u6708\uff0c\u9996\u4f4d\u4e2d\u570b\u60a3\u8005\u63a5\u53d7\u4e86efgartigimod\u6cbb\u7642\u3002<\/p>\n<p>2022\u5e74\u9810\u671f\u91cc\u7a0b\u7891\uff1a<\/p>\n<p>\u555f\u52d5\u91dd\u5c0d\u5169\u7a2e\u81ea\u8eab\u514d\u75ab\u6027\u814e\u75c5\u7684\u6982\u5ff5\u9a57\u8b49\u7814\u7a76\u3002<\/p>\n<p>\u8207argenx\u5408\u4f5c\u7e7c\u7e8c\u63a2\u7d22\u548c\u63a8\u9032\u5176\u4ed6\u9069\u61c9\u8b49\u7684\u7814\u7a76\u3002<\/p>\n<p>\u65bc2022\u5e74\u7b2c\u4e09\u5b63\u5ea6\u555f\u52d5\u91dd\u5c0d\u7279\u767c\u6027\u708e\u6027\u808c\u75c5\uff08\u808c\u708e\uff09\u7684\u4e09\u7a2e\u4e9e\u578b\uff08\u5305\u62ec\u514d\u75ab\u4ecb\u5c0e\u58de\u6b7b\u6027\u808c\u75c5\u3001\u6297\u5408\u6210\u9176\u7d9c\u5408\u75c7\u548c\u76ae\u808c\u708e\uff09\u7684\u8a3b\u518a\u6027\u7814\u7a76ALKIVIA\uff1b\u8a08\u5283\u91dd\u5c0d\u6bcf\u7a2e\u4e9e\u578b\u7684\u524d30\u540d\u60a3\u8005\u7684\u6578\u64da\u9032\u884c\u4e2d\u671f\u5206\u6790\u3002<\/p>\n<p>\u5411FDA\u905e\u4ea4efgartigimod\u76ae\u4e0b\u6ce8\u5c04\u5291\u578b\u6cbb\u7642\u5168\u8eab\u578b\u91cd\u75c7\u808c\u7121\u529b\u7684\u751f\u7269\u88fd\u54c1\u8a31\u53ef\u7533\u8acb\u3002<\/p>\n<p>\u6297\u611f\u67d3\u9818\u57df<\/p>\n<p>\u7d10\u518d\u6a02\u00ae\uff08\u7532\u82ef\u78fa\u9178\u5967\u99ac\u74b0\u7d20\uff09<\/p>\n<p>\u7d10\u518d\u6a02\u662f\u4e00\u6b3e\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u6216\u975c\u8108\u7d66\u85e5\u7684\u6297\u751f\u7d20\uff0c\u7528\u65bc\u6cbb\u7642\u5c0f\u5340\u7372\u5f97\u6027\u7d30\u83cc\u6027\u80ba\u708e\uff08CABP\uff09\u53ca\u6025\u6027\u7d30\u83cc\u6027\u76ae\u819a\u548c\u76ae\u819a\u7d50\u69cb\u611f\u67d3\uff08ABSSSI\uff09\u7684\u6210\u4eba\u60a3\u8005\u3002\u518d\u9f0e\u91ab\u85e5\u8ca0\u8cac\u5176\u5728\u4e2d\u570b\u7684\u958b\u767c\uff0c\u4e26\u65bc2021\u5e7412\u6708\u7372\u5f97NMPA\u6279\u51c6\u4e0a\u5e02\u3002<\/p>\n<p>2022\u5e74\u9810\u671f\u91cc\u7a0b\u7891\uff1a<\/p>\n<p>\u722d\u53d6\u5c07\u7d10\u518d\u6a02CABP\u548cABSSSI\u9069\u61c9\u8b49\u7d0d\u5165\u570b\u5bb6\u91ab\u4fdd\u85e5\u54c1\u76ee\u9304\u3002<\/p>\n<p>\u63d0\u4ea4\u518d\u9f0e\u91ab\u85e5\u7684\u4e0a\u5e02\u5f8c\u7814\u7a76\u8a08\u5283\u3002<\/p>\n<p>\u8212\u5df4\u5766-Durlobactam<\/p>\n<p>(SUL-DUR\uff0c\u4e9e\u592a\u5730\u5340\u6b0a\u76ca\uff09<\/p>\n<p>\u8212\u5df4\u5766-Durlobactam\u662f\u4e00\u6b3e\u03b2-\u5167\u9170\u80fa\u2571\u03b2-\u5167\u9170\u80fa\u9176\u6291\u5236\u5291\u7684\u7d44\u5408\u578b\u65b0\u85e5\uff0c\u5c0d\u65bc\u5305\u62ec\u78b3\u9752\u9709\u70ef\u985e\u8010\u85e5\u83cc\u682a\u5728\u5167\u7684\u9b91\u66fc\u4e0d\u52d5\u687f\u83cc\u5177\u6709\u7368\u7279\u6297\u83cc\u6d3b\u6027\u3002<\/p>\n<p>2022\u5e74\u9810\u671f\u91cc\u7a0b\u7891\uff1a<\/p>\n<p>\u65bc2022\u5e74\u7b2c\u56db\u5b63\u5ea6\u5411NMPA\u63d0\u4ea4\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\u3002<\/p>\n<p>\u65bc2022\u5e74\u7b2c\u4e09\u5b63\u5ea6\u5411FDA\u63d0\u4ea4\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\u3002<\/p>\n<p>\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u9818\u57df<\/p>\n<p>KarXT<\/p>\n<p>KarXT\u5c07\u65b0\u578b\u6bd2\u8548\u9e7c\u6fc0\u52d5\u5291\u546b\u8afe\u7f8e\u6797\u8207\u5df2\u7372\u6279\u7684\u6bd2\u8548\u9e7c\u62ee\u6297\u5291\u66f2\u53f8\u6c2f\u92a8\u7d50\u5408\u30022021\u5e7411\u6708\uff0c\u518d\u9f0e\u91ab\u85e5\u8207Karuna Therapeutics, Inc.\uff08Karuna\uff09\u5408\u4f5c\u5728\u5927\u4e2d\u83ef\u5340\u958b\u767cKarXT\u7528\u65bc\u6cbb\u7642\u7cbe\u795e\u5206\u88c2\u75c7\u548c\u5176\u4ed6\u9069\u61c9\u8b49\uff0c\u5982\u7661\u5446\u76f8\u95dc\u7684\u7cbe\u795e\u75c5\u6027\u969c\u7919\u3002<\/p>\n<p>\u8fd1\u671f\u7522\u54c1\u4eae\u9ede\uff1a<\/p>\n<p>2022\u5e748\u6708\uff0c\u518d\u9f0e\u91ab\u85e5\u7684\u5408\u4f5c\u5925\u4f34Karuna\u5ba3\u4f48\u4e863\u671f\u81e8\u5e8a\u7814\u7a76EMERGENT-2\u7684\u967d\u6027\u521d\u6b65\u7d50\u679c\uff0c\u8a72\u7814\u7a76\u8a55\u4f30\u4e86\u5176\u5728\u6210\u4eba\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005\u4e2d\u7684\u7642\u6548\u3001\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002\u8a72\u7814\u7a76\u9054\u5230\u4e86\u5176\u4e3b\u8981\u7d42\u9ede\uff0c\u5728\u7b2c\u4e94\u5468\u6642\u8207\u5b89\u6170\u5291\u76f8\u6bd4\uff0cKarXT\u5728\u967d\u6027\u548c\u9670\u6027\u7d9c\u5408\u75c7\u91cf\u8868\uff08PANSS\uff09\u7e3d\u5206\u964d\u4f4e\u4e86\u5177\u6709\u7d71\u8a08\u5b78\u610f\u7fa9\u548c\u81e8\u5e8a\u610f\u7fa9\u76849.6\u5206\uff08-21.2 KarXT\u5c0d\u6bd4-11.6\u5b89\u6170\u5291\uff0cp&lt;0.0001\uff09\u3002\u5f9e\u7b2c2\u5468\u958b\u59cb\uff0c\u6839\u64daPANSS\u7e3d\u5206\u8a55\u4f30\uff0cKarXT\u9084\u8868\u73fe\u51fa\u65e9\u671f\u548c\u6301\u7e8c\u7684\u5177\u6709\u7d71\u8a08\u5b78\u610f\u7fa9\u7684\u986f\u8457\u75c7\u72c0\u6e1b\u5c11\uff0c\u4e26\u6301\u7e8c\u81f3\u7814\u7a76\u7d50\u675f\u3002<\/p>\n<p>\u8a72\u7814\u7a76\u4e5f\u9054\u5230\u4e86\u95dc\u9375\u6b21\u8981\u7d42\u9ede\uff0c\u901a\u904ePANSS\u967d\u6027\u75c7\u72c0\u3001PANSS\u9670\u6027\u75c7\u72c0\u548cPANSS Marder\u9670\u6027\u75c7\u72c0\u4efd\u91cf\u8868\uff0c\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u967d\u6027\u548c\u9670\u6027\u75c7\u72c0\u5747\u5be6\u73fe\u5728\u7d71\u8a08\u5b78\u4e0a\u986f\u8457\u6e1b\u5c11\u3002   KarXT\u7684\u7e3d\u9ad4\u8010\u53d7\u6027\u826f\u597d\uff0c\u4e0d\u826f\u53cd\u61c9\u7279\u5fb5\u8207\u4e4b\u524d\u7684KarXT\u5728\u7cbe\u795e\u5206\u88c2\u75c7\u4e2d\u7684\u7814\u7a76\u57fa\u672c\u4e00\u81f4\u3002  <\/p>\n<p>2022\u5e74\u9810\u671f\u91cc\u7a0b\u7891\uff1a<\/p>\n<p>\u5c31\u7cbe\u795e\u5206\u88c2\u75c7\u8a3b\u518a\u76f8\u95dc\u4e8b\u5b9c\u5411\u8a3b\u518a\u90e8\u9580\u9032\u884c\u54a8\u8a62\u3002<\/p>\n<p>\u65bc2022\u5e74\u7b2c\u4e09\u5b63\u5ea6\u555f\u52d5\u8a55\u4f30KarXT\u6cbb\u7642\u963f\u8328\u6d77\u9ed8\u75c7\u7cbe\u795e\u75c5\u6027\u969c\u7919\u76843\u671fADEPT-1\u7814\u7a76\u3002<\/p>\n<p>\u5168\u7403\u7814\u767c\u9805\u76ee<\/p>\n<p>ZL-1102<\/p>\n<p>(IL-17\u5168\u4eba\u6e90VH\u6297\u9ad4\u7247\u6bb5\uff0c\u5168\u7403\u6b0a\u5229)<\/p>\n<p>ZL-1102\u662f\u4e00\u6b3e\u65b0\u578b\u5168\u4eba\u6e90VH\u6297\u9ad4\u7247\u6bb5\uff08Humabody\u00ae\uff09\uff0c\u9776\u5411\u4f5c\u7528\u65bcIL-17A\u7d30\u80de\u56e0\u5b50\uff0c\u5177\u6709\u9ad8\u89aa\u548c\u529b\u548c\u6d3b\u6027\u3002\u6709\u5225\u65bc\u5176\u4ed6\u6297IL-17\u7522\u54c1\uff0cZL-1102\u6b63\u5728\u958b\u767c\u7528\u65bc\u8f15\u4e2d\u5ea6\u6162\u6027\u6591\u584a\u72c0\u9280\u5c51\u75c5\uff08CPP\uff09\u7684\u5c40\u90e8\u6cbb\u7642\u3002<\/p>\n<p>\u8fd1\u671f\u7522\u54c1\u4eae\u9ede\uff1a<\/p>\n<p>\u8a55\u4f30ZL-1102\u5728\u8f15\u4e2d\u5ea6CPP\u60a3\u8005\u4e2d\u7642\u6548\u548c\u5b89\u5168\u6027\u76841\u671f\u6982\u5ff5\u9a57\u8b49\u7814\u7a76\u7684\u7d50\u679c\uff0c\u5df2\u5165\u90782022\u5e749\u67087\u65e5\u201310\u65e5\u7684EADV\uff08\u6b50\u6d32\u76ae\u819a\u75c5\u5b78\u548c\u6027\u75c5\u5b78\u6703\uff09\u5e74\u6703\u53e3\u982d\u5831\u544a\u3002<\/p>\n<p>2022\u5e74\u9810\u671f\u91cc\u7a0b\u7891\uff1a<\/p>\n<p>\u65bc2022\u5e74\u7b2c\u56db\u5b63\u5ea6\u555f\u52d5\u7528\u65bcCPP\u6cbb\u7642\u7684\u5168\u74032\u671f\u7814\u7a76\u3002<\/p>\n<p>Simurosertib, ZL-2309<\/p>\n<p>(CDC7\u6291\u5236\u5291\uff0c\u5168\u7403\u6b0a\u5229)<\/p>\n<p>Simurosertib\uff08\u53c8\u7a31ZL-2309\uff09\u662f\u4e00\u6b3e\u53e3\u670d\u3001\u9078\u64c7\u6027CDC7\u6291\u5236\u5291\u3002CDC7\u662f\u4e00\u7a2e\u86cb\u767d\u6fc0\u9176\uff0c\u5728 DNA\u8907\u88fd\u548c\u7e5e\u904eDNA\u640d\u50b7\u53cd\u61c9\u4e2d\u8d77\u95dc\u9375\u4f5c\u7528\u3002<\/p>\n<p>\u8fd1\u671f\u7522\u54c1\u9032\u5c55\uff1a<\/p>\n<p>\u57fa\u65bc\u5c0d\u6b64\u524d\u5b8c\u6210\u7684\u7814\u7a76\u4e2d\u6536\u96c6\u7684\u6578\u64da\u7684\u5168\u9762\u8a55\u4f30\uff0c\u518d\u9f0e\u91ab\u85e5\u6c7a\u5b9a\u7d42\u6b62simurosertib\u7814\u7a76\u7684\u60a3\u8005\u5165\u7d44\u3002<\/p>\n<p>ZL-1201<\/p>\n<p>(CD47\u6291\u5236\u5291\uff0c\u5168\u7403\u6b0a\u5229)<\/p>\n<p>ZL-1201\u662f\u4e00\u6b3e\u7d93\u5de5\u7a0b\u5316\u6539\u826f\u964d\u4f4e\u4e86\u6548\u61c9\u529f\u80fd\uff0c\u7279\u7570\u6027\u9776\u5411CD47\u7684\u4eba\u6e90\u5316IgG4\u55ae\u514b\u9686\u6297\u9ad4\u3002ZL-1201\u55ae\u85e5\u548c\u806f\u5408\u6cbb\u7642\u7684\u6cbb\u7642\u6f5b\u529b\uff0c\u5c07\u5728\u5be6\u9ad4\u7624\u548c\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u4e2d\u9032\u884c\u8a55\u4f30\u3002<\/p>\n<p>\u8fd1\u671f\u7522\u54c1\u9032\u5c55\uff1a<\/p>\n<p>2022\u5e747\u6708\uff0c\u518d\u9f0e\u91ab\u85e5\u901a\u904e\u6b63\u5728\u9032\u884c\u76841\u671f\u81e8\u5e8a\u7814\u7a76\u78ba\u5b9a\u4e862\u671f\u63a8\u85a6\u5291\u91cf\u3002<\/p>\n<p>\u57fa\u65bc\u5c0d\u7af6\u722d\u683c\u5c40\u7684\u8a55\u4f30\uff0c\u518d\u9f0e\u91ab\u85e5\u6c7a\u5b9a\u964d\u4f4eZL-1201\u7684\u5167\u90e8\u958b\u767c\u512a\u5148\u7d1a\uff0c\u4f46\u5c0d\u65bc\u5c0d\u5916\u6388\u6b0a\u6301\u958b\u653e\u614b\u5ea6\u3002<\/p>\n<p>\u516c\u53f8\u6700\u65b0\u52d5\u614b<\/p>\n<p>2022\u5e746\u6708\uff0c\u518d\u9f0e\u91ab\u85e5\u5b8c\u6210\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e3b\u677f\u7531\u7b2c\u4e8c\u4e0a\u5e02\u81ea\u9858\u8f49\u63db\u70ba\u4e3b\u8981\u4e0a\u5e02\u3002\u518d\u9f0e\u91ab\u85e5\u73fe\u5728\u662f\u4e00\u5bb6\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u548c\u7d0d\u65af\u9054\u514b\u96d9\u91cd\u4e3b\u8981\u4e0a\u5e02\u7684\u516c\u53f8\u3002<\/p>\n<p>2022\u5e746\u6708\u548c7\u6708\uff0c\u518d\u9f0e\u91ab\u85e5\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4ea4\u6613\u7684\u666e\u901a\u80a1\u5206\u5225\u88ab\u7d0d\u5165\u6df1\u6e2f\u901a\u548c\u6eec\u6e2f\u901a\u80a1\u7968\u540d\u55ae\u3002\u88ab\u7d0d\u5165\u6df1\u6e2f\u901a\u548c\u6eec\u6e2f\u901a\u5c07\u4fbf\u6377\u4e2d\u570b\u5167\u5730\u7b26\u5408\u689d\u4ef6\u7684\u6295\u8cc7\u8005\u5c0d\u518d\u9f0e\u91ab\u85e5\u53ca\u5176\u80a1\u7968\u7684\u6295\u8cc7\u3002<\/p>\n<p>\u518d\u9f0e\u91ab\u85e5\u8058\u8acb\u7562\u99ac\u5a01\u6703\u8a08\u5e2b\u4e8b\u52d9\u6240\uff08KPMG LLP\uff09\u4f5c\u70ba\u516c\u53f8\u7684\u5be9\u8a08\u6a5f\u69cb\uff0c\u81ea2022\u5e745\u670831\u65e5\u8d77\u751f\u6548\u3002\u516c\u53f8\u8a8d\u70ba\uff0c\u5f9e\u622a\u81f32022\u5e7412\u670831\u65e5\u6b62\u7684\u8ca1\u5e74\u5e74\u5ea6\u5831\u544a\u958b\u59cb\uff0c\u516c\u53f8\u5c07\u7b26\u5408\u300a\u5916\u570b\u516c\u53f8\u554f\u8cac\u6cd5\u6848\u300b\uff08HFCAA\uff09\u7684\u8981\u6c42\uff0c\u4e26\u4e14\u516c\u53f8\u57282023\u5e74\u6216\u5176\u5f8c\u5c07\u4e0d\u6703\u88ab\u5217\u5165HFCAA\u9805\u4e0b\u7684\u6700\u7d42\u8a8d\u5b9a\u540d\u55ae\u3002\u56e0\u6b64\u516c\u53f8\u9810\u8a08\uff0c\u5176\u5728\u7d0d\u65af\u9054\u514b\u7684\u639b\u724c\u5c07\u4e0d\u6703\u4e2d\u65b7\u3002\u516c\u53f8\u95dc\u65bc\u8058\u8acb\u7562\u99ac\u5a01\u6703\u8a08\u5e2b\u4e8b\u52d9\u6240\u7684\u5b8c\u6574\u8072\u660e\u53ef\u767b\u9304\u518d\u9f0e\u91ab\u85e5\u5b98\u7db2\u7684\u6295\u8cc7\u8005\u95dc\u4fc2\u7248\u584a\u67e5\u8a62\u3002<\/p>\n<p>\u518d\u9f0e\u91ab\u85e5\u4e0d\u65b7\u6539\u5584\u516c\u53f8\u6cbb\u7406\u548c\u58ef\u5927\u5718\u968a\u30022022\u5e747\u6708\uff0c\u8463\u4e8b\u6703\u4efb\u547dJohn Diekman\u70ba\u9996\u5e2d\u7368\u7acb\u8463\u4e8b\u3002\u9452\u65bc\u9996\u5e2d\u7368\u7acb\u8463\u4e8b\u7684\u984d\u5916\u8077\u8cac\uff0cDiekman\u5148\u751f\u4e0d\u518d\u64d4\u4efb\u5be9\u6838\u59d4\u54e1\u6703\u4e3b\u5e2d\u4e00\u8077\uff0c\u4f46\u4ed6\u5c07\u7e7c\u7e8c\u64d4\u4efb\u5be9\u6838\u59d4\u54e1\u6703\u7684\u6210\u54e1\uff0c\u4e26\u4e14Scott Morrison\u88ab\u4efb\u547d\u70ba\u5be9\u6838\u59d4\u54e1\u6703\u4e3b\u5e2d\u3002\u6b64\u5916\uff0cJosh Smiley\u65bc8\u67081\u65e5\u52a0\u5165\u516c\u53f8\u64d4\u4efb\u9996\u5e2d\u904b\u71df\u5b98\u3002\u4ed6\u5c07\u76f4\u63a5\u5411\u9996\u5e2d\u57f7\u884c\u5b98\u532f\u5831\u4e26\u6210\u70ba\u7ba1\u7406\u5718\u968a\u7684\u91cd\u8981\u6210\u54e1\u3002<\/p>\n<p>\u622a\u81f32022\u5e746\u670830\u65e5\uff0c\u518d\u9f0e\u91ab\u85e5\u5171\u67092,063\u540d\u5168\u8077\u54e1\u5de5\uff0c\u5176\u4e2d\u5f9e\u4e8b\u7814\u767c\u548c\u5546\u696d\u5316\u5d17\u4f4d\u7684\u54e1\u5de5\u6578\u91cf\u5206\u5225\u70ba861\u4eba\u548c968\u4eba\u3002<\/p>\n<p>2022\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u8ca1\u52d9\u696d\u7e3e<\/p>\n<p>\u622a\u81f32022\u5e746\u670830\u65e5\u6b62\u4e09\u500b\u6708\uff0c\u7e3d\u6536\u5165\u70ba4,820\u842c\u7f8e\u5143\uff0c2021\u5e74\u540c\u671f\u6536\u5165\u70ba3,690\u842c\u7f8e\u5143\u3002\u5176\u4e2d\u5305\u62ec\u5247\u6a02\u7522\u54c1\u92b7\u552e\u6536\u51653,410\u842c\u7f8e\u5143\uff082021\u5e74\u540c\u671f\u70ba2,340\u842c\u7f8e\u5143\uff09\u3001\u611b\u666e\u76fe\u7522\u54c1\u92b7\u552e\u6536\u51651,160\u842c\u7f8e\u5143\uff082021\u5e74\u540c\u671f\u70ba950\u842c\u7f8e\u5143\uff09\u3001\u64ce\u6a02\u7522\u54c1\u92b7\u552e\u6536\u516560\u842c\u7f8e\u5143\uff082021\u5e74\u540c\u671f\u70ba400\u842c\u7f8e\u5143\uff09\u3001\u7d10\u518d\u6a02\u7522\u54c1\u92b7\u552e\u6536\u5165130\u842c\u7f8e\u5143\uff082021\u5e74\u540c\u671f\u7121\u6536\u5165\uff09\u3002<\/p>\n<p>\u516c\u53f8\u65bc2022\u5e746\u6708\u964d\u4f4e\u4e86\u64ce\u6a02\u548c\u7d10\u518d\u6a02\u5c0d\u4f9b\u61c9\u5546\u7684\u552e\u50f9\u3002\u56e0\u6b64\uff0c\u5728\u622a\u81f32022\u5e746\u670830\u65e5\u6b62\u7684\u4e09\u500b\u6708\u5167\uff0c\u516c\u53f8\u8a08\u63d0\u92b7\u552e\u8fd4\u5229290\u842c\u7f8e\u5143\uff0c\u4f5c\u70ba\u5c31\u6b64\u524d\u4ee5\u964d\u50f9\u524d\u50f9\u683c\u51fa\u552e\u7684\u7522\u54c1\u5411\u7d93\u92b7\u5546\u4f5c\u51fa\u7684\u88dc\u511f\u3002 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\u9810\u8a08\u5728\u5373\u5c07\u53ec\u958b\u7684\u91ab\u5b78\u6703\u8b70\u4e0a\uff0c\u8a73\u7d30\u66f4\u65b0\u7d93BICR\u5206\u6790\u7684TRIDENT-1\u7684\u7814\u7a76\u7d50\u679c\uff0c\u5305\u62ec\u9871\u5167\u6d3b\u6027\u7684\u7814\u7a76\u7d50\u679c\u3002 \u63d0\u4f9bTRIDENT-1\u7814\u7a76\u4e2dNTRK\u967d\u6027\u665a\u671f\u5be6\u9ad4\u7624\u968a\u5217\u7684\u81e8\u5e8a\u6578\u64da\u66f4\u65b0\u3002 CLN-081 CLN-081\u662f\u4e00\u6b3e\u53e3\u670d\u3001\u4e0d\u53ef\u9006\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\uff08EGFR\uff09\u6291\u5236\u5291\uff0c\u53ef\u4ee5\u9078\u64c7\u6027\u5730\u9776\u5411\u4f5c\u7528\u65bcEGFR\u5916\u986f\u5b5020\u63d2\u5165\u7a81\u8b8a\uff0c\u540c\u6642\u907f\u958b\u8868\u9054\u91ce\u751f\u578bEGFR\u7684\u7d30\u80de\u3002 \u8fd1\u671f\u7522\u54c1\u4eae\u9ede\uff1a 2022\u5e746\u6708\uff0c\u518d\u9f0e\u91ab\u85e5\u5408\u4f5c\u5925\u4f34Cullinan Oncology\u57282022\u5e74ASCO\u5e74\u6703\u4e0a\u516c\u4f48\u4e86\u91dd\u5c0dEGFR\u5916\u986f\u5b5020\u63d2\u5165\u7a81\u8b8a\u7684NSCLC\u60a3\u8005\u76841\/2a\u671f\u7814\u7a76\u7684\u66f4\u65b0\u6578\u64da\u3002\u5728100mg\u6bcf\u65e5\u5169\u6b21\u5291\u91cf\u7d44\u768439\u540d\u60a3\u8005\u4e2d\uff1a 16\u540d\uff0841%\uff09\u60a3\u8005\u78ba\u5b9a\u90e8\u5206\u7de9\u89e3\u3002 \u9810\u4f30\u4e2d\u4f4d\u7de9\u89e3\u6301\u7e8c\u6642\u9593\u8d85\u904e21\u500b\u6708\u3002 \u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\u70ba12\u500b\u6708\u3002 CLN-081\u7684\u5b89\u5168\u6027\u4f7f\u5176\u53ef\u7528\u65bc\u9577\u671f\u6cbb\u7642\u3002 2022\u5e74\u9810\u671f\u91cc\u7a0b\u7891\uff1a \u5728\u5b8c\u6210\u98df\u7269\u6548\u61c9\u85e5\u4ee3\u52d5\u529b\u5b78\uff08PK\uff09\u7814\u7a76\u5f8c\uff0c\u555f\u52d5\u95dc\u9375\u6027\u7814\u7a76\u3002 Elzovantinib (TPX-0022) Elzovantinib\u662f\u4e00\u6b3e\u53e3\u670d\u591a\u9776\u9ede\u6fc0\u9176\u6291\u5236\u5291\uff0c\u5177\u6709\u65b0\u578b\u4e09\u7dad\u5927\u74b0\u7d50\u69cb\uff0c\u53ef\u6291\u5236MET\u3001CSF1R\uff08\u96c6\u843d\u523a\u6fc0\u56e0\u5b501\u53d7\u9ad4\uff09\u53caSRC\u6fc0\u9176\u3002\u00a0 2022\u5e74\u9810\u671f\u91cc\u7a0b\u7891\uff1a \u5168\u74031\/2\u671f\u81e8\u5e8a\u7814\u7a76SHIELD-1\u76841\u671f\u64f4\u5c55\u90e8\u5206\u5b8c\u6210\u5927\u4e2d\u83ef\u5340\u9996\u4f4d\u60a3\u8005\u5165\u7d44\u3002 \u63d0\u4f9bSHIELD-1 1\u671f\u7814\u7a76\u7684\u81e8\u5e8a\u6578\u64da\u66f4\u65b0\u3002 \u8996FDA\u5c0d\u4e2d\u7b49\u5291\u91cf\u6c34\u5e73\u6578\u64da\u7684\u53cd\u994b\u800c\u5b9a\uff0c\u555f\u52d5SHIELD-1\u81e8\u5e8a\u7814\u7a76\u76842\u671f\u90e8\u5206\u3002 BLU-945 BLU-945\u662f\u4e00\u6b3e\u8655\u65bc\u7814\u7a76\u968e\u6bb5\u7684\u9078\u64c7\u6027\u3001\u5f37\u6548\u7684EGFR\u6291\u5236\u5291\uff0c\u53ef\u4ee5\u6291\u5236L858R\u6d3b\u5316\u7a81\u8b8a\u621619\u5916\u986f\u5b50\u7f3a\u5931\u7a81\u8b8a\u4f34\u6709\u7372\u5f97\u6027T790M\u548cC797S\u7a81\u8b8a\uff0c\u9019\u4e9b\u7a81\u8b8a\u5206\u5225\u662f\u7b2c\u4e00\u4ee3EGFR\u6291\u5236\u5291\u548c\u5967\u5e0c\u66ff\u5c3c\u5e38\u898b\u7684\u9776\u5167\u8010\u85e5\u7a81\u8b8a\u3002BLU-945\u6709\u671b\u7528\u65bc\u6cbb\u7642EGFR\u9a45\u52d5\u7684\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u3002 \u8fd1\u671f\u7522\u54c1\u4eae\u9ede\uff1a 2022\u5e746\u6708\uff0c\u518d\u9f0e\u91ab\u85e5\u7372\u5f97\u4e86\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u5c0d\u5168\u74031\/2\u671f\u81e8\u5e8a\u7814\u7a76SYMPHONY\u4e2dBLU-945\u55ae\u85e5\u968a\u5217\u5728\u5927\u4e2d\u83ef\u5340\u7684\u81e8\u5e8a\u8a66\u9a57\u6279\u4ef6\u3002 2022\u5e74\u9810\u671f\u91cc\u7a0b\u7891\uff1a 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BLU-701\u662f\u4e00\u6b3e\u8655\u65bc\u7814\u7a76\u968e\u6bb5\u7684\u9078\u64c7\u6027\u3001\u5f37\u6548\u7684EGFR\u6291\u5236\u5291\uff0c\u53ef\u4ee5\u6291\u5236L858R\u6d3b\u5316\u7a81\u8b8a\u621619\u5916\u986f\u5b50\u7f3a\u5931\u7a81\u8b8a\u4f34\u6709\u7372\u5f97\u6027C797S\u7a81\u8b8a\uff0c\u9019\u4e9b\u7a81\u8b8a\u662f\u5967\u5e0c\u66ff\u5c3c\u5e38\u898b\u7684\u9776\u5167\u8010\u85e5\u7a81\u8b8a\u3002BLU-701\u6709\u671b\u7528\u65bc\u6cbb\u7642EGFR\u9a45\u52d5\u7684\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u3002 2022\u5e74\u9810\u671f\u91cc\u7a0b\u7891\uff1a \u516c\u4f48BLU-701\u6cbb\u7642EGFR\u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u76841\/2\u671f\u81e8\u5e8a\u7814\u7a76HARMONY\u7684\u521d\u6b65\u81e8\u5e8a\u6578\u64da\u3002 \u81ea\u8eab\u514d\u75ab\u75be\u75c5\u9818\u57df VYVGART\u00ae\uff08Efgartigimod\uff09 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2022\u5e746\u6708\uff0cefgartigimod\u843d\u5730\u6d77\u5357\u535a\u9c32\u6a02\u57ce\u570b\u969b\u91ab\u7642\u65c5\u904a\u5148\u884c\u5340\u30022022\u5e747\u6708\uff0c\u9996\u4f4d\u4e2d\u570b\u60a3\u8005\u63a5\u53d7\u4e86efgartigimod\u6cbb\u7642\u3002 2022\u5e74\u9810\u671f\u91cc\u7a0b\u7891\uff1a \u555f\u52d5\u91dd\u5c0d\u5169\u7a2e\u81ea\u8eab\u514d\u75ab\u6027\u814e\u75c5\u7684\u6982\u5ff5\u9a57\u8b49\u7814\u7a76\u3002 \u8207argenx\u5408\u4f5c\u7e7c\u7e8c\u63a2\u7d22\u548c\u63a8\u9032\u5176\u4ed6\u9069\u61c9\u8b49\u7684\u7814\u7a76\u3002 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Oncology\u57282022\u5e74ASCO\u5e74\u6703\u4e0a\u516c\u4f48\u4e86\u91dd\u5c0dEGFR\u5916\u986f\u5b5020\u63d2\u5165\u7a81\u8b8a\u7684NSCLC\u60a3\u8005\u76841\/2a\u671f\u7814\u7a76\u7684\u66f4\u65b0\u6578\u64da\u3002\u5728100mg\u6bcf\u65e5\u5169\u6b21\u5291\u91cf\u7d44\u768439\u540d\u60a3\u8005\u4e2d\uff1a 16\u540d\uff0841%\uff09\u60a3\u8005\u78ba\u5b9a\u90e8\u5206\u7de9\u89e3\u3002 \u9810\u4f30\u4e2d\u4f4d\u7de9\u89e3\u6301\u7e8c\u6642\u9593\u8d85\u904e21\u500b\u6708\u3002 \u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\u70ba12\u500b\u6708\u3002 CLN-081\u7684\u5b89\u5168\u6027\u4f7f\u5176\u53ef\u7528\u65bc\u9577\u671f\u6cbb\u7642\u3002 2022\u5e74\u9810\u671f\u91cc\u7a0b\u7891\uff1a \u5728\u5b8c\u6210\u98df\u7269\u6548\u61c9\u85e5\u4ee3\u52d5\u529b\u5b78\uff08PK\uff09\u7814\u7a76\u5f8c\uff0c\u555f\u52d5\u95dc\u9375\u6027\u7814\u7a76\u3002 Elzovantinib (TPX-0022) Elzovantinib\u662f\u4e00\u6b3e\u53e3\u670d\u591a\u9776\u9ede\u6fc0\u9176\u6291\u5236\u5291\uff0c\u5177\u6709\u65b0\u578b\u4e09\u7dad\u5927\u74b0\u7d50\u69cb\uff0c\u53ef\u6291\u5236MET\u3001CSF1R\uff08\u96c6\u843d\u523a\u6fc0\u56e0\u5b501\u53d7\u9ad4\uff09\u53caSRC\u6fc0\u9176\u3002\u00a0 2022\u5e74\u9810\u671f\u91cc\u7a0b\u7891\uff1a \u5168\u74031\/2\u671f\u81e8\u5e8a\u7814\u7a76SHIELD-1\u76841\u671f\u64f4\u5c55\u90e8\u5206\u5b8c\u6210\u5927\u4e2d\u83ef\u5340\u9996\u4f4d\u60a3\u8005\u5165\u7d44\u3002 \u63d0\u4f9bSHIELD-1 1\u671f\u7814\u7a76\u7684\u81e8\u5e8a\u6578\u64da\u66f4\u65b0\u3002 \u8996FDA\u5c0d\u4e2d\u7b49\u5291\u91cf\u6c34\u5e73\u6578\u64da\u7684\u53cd\u994b\u800c\u5b9a\uff0c\u555f\u52d5SHIELD-1\u81e8\u5e8a\u7814\u7a76\u76842\u671f\u90e8\u5206\u3002 BLU-945 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Oncology\u57282022\u5e74ASCO\u5e74\u6703\u4e0a\u516c\u4f48\u4e86\u91dd\u5c0dEGFR\u5916\u986f\u5b5020\u63d2\u5165\u7a81\u8b8a\u7684NSCLC\u60a3\u8005\u76841\/2a\u671f\u7814\u7a76\u7684\u66f4\u65b0\u6578\u64da\u3002\u5728100mg\u6bcf\u65e5\u5169\u6b21\u5291\u91cf\u7d44\u768439\u540d\u60a3\u8005\u4e2d\uff1a 16\u540d\uff0841%\uff09\u60a3\u8005\u78ba\u5b9a\u90e8\u5206\u7de9\u89e3\u3002 \u9810\u4f30\u4e2d\u4f4d\u7de9\u89e3\u6301\u7e8c\u6642\u9593\u8d85\u904e21\u500b\u6708\u3002 \u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\u70ba12\u500b\u6708\u3002 CLN-081\u7684\u5b89\u5168\u6027\u4f7f\u5176\u53ef\u7528\u65bc\u9577\u671f\u6cbb\u7642\u3002 2022\u5e74\u9810\u671f\u91cc\u7a0b\u7891\uff1a \u5728\u5b8c\u6210\u98df\u7269\u6548\u61c9\u85e5\u4ee3\u52d5\u529b\u5b78\uff08PK\uff09\u7814\u7a76\u5f8c\uff0c\u555f\u52d5\u95dc\u9375\u6027\u7814\u7a76\u3002 Elzovantinib (TPX-0022) 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