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[1]Jiang, H., Pang, S., Zhang, Y. et al. A phase 1b randomised controlled trial of a glucagon-like peptide-1 and glucagon receptor dual agonist IBI362 (LY3305677) in Chinese patients with type 2 diabetes. Nat Commun 13, 3613 (2022). https:\/\/doi.org\/10.1038\/s41467-022-31328-x<\/span><\/p>\n

[2]Ji L, Jiang H, An P, et al. (2021) IBI362 (LY3305677), a weekly-dose GLP-1 and glucagon receptor dual agonist, in Chinese adults with overweight or obesity: A randomised, placebo-controlled, multiple ascending dose phase 1b study. EClinicalMedicine 39: 101088. 10.1016\/j.eclinm.2021.101088<\/span><\/p>\n<\/div>\n

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\u95dc\u65bc Mazdutide\uff08IBI362\uff09<\/p>\n

Mazdutide\uff08IBI362\uff09\u662f\u4fe1\u9054\u751f\u7269\u88fd\u85e5\u8207\u79ae\u4f86\u88fd\u85e5\u5171\u540c\u63a8\u9032\u7684\u4e00\u6b3e\u80c3\u6ccc\u9178\u8abf\u7bc0\u7d20\u5275\u65b0\u5316\u5408\u7269\uff08OXM3\uff09\uff0c\u5728\u540c\u985e\u7522\u54c1\u4e2d\u5177\u6709\u6700\u512a\u6f5b\u529b\u3002\u4f5c\u70ba\u4e00\u7a2e\u8207\u54fa\u4e73\u52d5\u7269\u80c3\u6ccc\u9178\u8abf\u7bc0\u7d20\u985e\u4f3c\u7684\u9577\u6548\u5408\u6210\u80bd\uff0cmazdutide\u5229\u7528\u8102\u80aa\u9170\u57fa\u5074\u93c8\u5ef6\u9577\u4f5c\u7528\u6642\u9593\uff0c\u5141\u8a31\u6bcf\u9031\u7d66\u85e5\u4e00\u6b21\u3002Mazdutide\u7684\u4f5c\u7528\u88ab\u8a8d\u70ba\u662f\u901a\u904eGLP-1R\u548cGCGR\u7684\u7d50\u5408\u548c\u6fc0\u6d3b\u4ecb\u5c0e\u7684\uff0c\u8207OXM\u5177\u6709\u76f8\u4f3c\u4f5c\u7528\u6a5f\u5236\uff0c\u56e0\u6b64\u9810\u8a08\u5176\u53ef\u4ee5\u6539\u5584\u8461\u8404\u7cd6\u8010\u91cf\u4e26\u6e1b\u8f15\u9ad4\u91cd\u3002\u9664\u4e86GLP-1R\u6fc0\u52d5\u5291\u5177\u6709\u7684\u4fc3\u9032\u80f0\u5cf6\u7d20\u5206\u6ccc\u3001\u964d\u4f4e\u8840\u7cd6\u548c\u6e1b\u8f15\u9ad4\u91cd\u7b49\u4f5c\u7528\u5916\uff0cmazdutide\u9084\u53ef\u80fd\u901a\u904eGCGR\u7684\u6fc0\u6d3b\u5177\u6709\u589e\u52a0\u80fd\u91cf\u6d88\u8017\u548c\u6539\u5584\u809d\u81df\u8102\u80aa\u4ee3\u8b1d\u7b49\u6548\u61c9\u3002\u901a\u904e\u958b\u767c\u540c\u6642\u6fc0\u52d5\u591a\u500b\u8207\u4ee3\u8b1d\u76f8\u95dc\u7684\u9776\u9ede\u4f86\u6cbb\u7642\u4ee3\u8b1d\u6027\u75be\u75c5\u662f\u76ee\u524d\u570b\u969b\u4e0a\u65b0\u85e5\u7814\u767c\u6700\u65b0\u7684\u8da8\u52e2\u3002<\/p>\n

\u95dc\u65bc\u4fe1\u9054\u751f\u7269<\/p>\n

\u300c\u59cb\u65bc\u4fe1\uff0c\u9054\u65bc\u884c\u300d\uff0c\u958b\u767c\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8cea\u91cf\u751f\u7269\u85e5\uff0c\u662f\u4fe1\u9054\u751f\u7269\u7684\u7406\u60f3\u548c\u76ee\u6a19\u3002\u4fe1\u9054\u751f\u7269\u6210\u7acb\u65bc2011\u5e74\uff0c\u81f4\u529b\u65bc\u958b\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u7684\u5275\u65b0\u85e5\u7269\u30022018\u5e7410\u670831\u65e5\uff0c\u4fe1\u9054\u751f\u7269\u88fd\u85e5\u5728\u9999\u6e2f\u806f\u5408\u4ea4\u6613\u6240\u6709\u9650\u516c\u53f8\u4e3b\u677f\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a01801\u3002<\/p>\n

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\u4fe1\u9054\u751f\u7269\u5df2\u7d44\u5efa\u4e86\u4e00\u652f\u5177\u6709\u570b\u969b\u5148\u9032\u6c34\u5e73\u7684\u9ad8\u7aef\u751f\u7269\u85e5\u958b\u767c\u3001\u7522\u696d\u5316\u4eba\u624d\u5718\u968a\uff0c\u5305\u62ec\u773e\u591a\u6d77\u6b78\u5c08\u5bb6\uff0c\u4e26\u8207\u7f8e\u570b\u79ae\u4f86\u88fd\u85e5\u3001Adimab\u3001Incyte\u3001MD Anderson \u764c\u75c7\u4e2d\u5fc3\u548c\u97d3\u570bHanmi\u7b49\u570b\u969b\u5408\u4f5c\u65b9\u9054\u6210\u6230\u7565\u5408\u4f5c\u3002\u4fe1\u9054\u751f\u7269\u5e0c\u671b\u548c\u5927\u5bb6\u4e00\u8d77\u52aa\u529b\uff0c\u63d0\u9ad8\u4e2d\u570b\u751f\u7269\u88fd\u85e5\u7522\u696d\u7684\u767c\u5c55\u6c34\u5e73\uff0c\u4ee5\u6eff\u8db3\u767e\u59d3\u7528\u85e5\u53ef\u53ca\u6027\u548c\u4eba\u6c11\u5c0d\u751f\u547d\u5065\u5eb7\u7f8e\u597d\u9858\u671b\u7684\u8ffd\u6c42\u3002<\/p>\n

\u8a73\u60c5\u8acb\u8a2a\u554f\u516c\u53f8\u7db2\u7ad9\uff1awww.innoventbio.com<\/a>\u6216\u516c\u53f8\u9818\u82f1\u8cec\u865f\uff1aInnovent Biologics\u3002<\/p>\n

\u8072\u660e\uff1a<\/p>\n

1. \u8a72\u9069\u61c9\u75c7\u70ba\u7814\u7a76\u4e2d\u7684\u85e5\u54c1\u7528\u6cd5\uff0c\u5c1a\u672a\u5728\u4e2d\u570b\u7372\u6279\uff1b<\/p>\n

2. \u4fe1\u9054\u4e0d\u63a8\u85a6\u4efb\u4f55\u672a\u7372\u6279\u7684\u85e5\u54c1\/\u9069\u61c9\u75c7\u4f7f\u7528\u3002<\/p>\n

\u524d\u77bb\u6027\u8072\u660e<\/p>\n

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\u9019\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u4e43\u57fa\u65bc\u672c\u516c\u53f8\u7ba1\u7406\u5c64\u5728\u505a\u51fa\u8868\u8ff0\u6642\u5c0d\u672a\u4f86\u4e8b\u52d9\u7684\u73fe\u6709\u770b\u6cd5\u3001\u5047\u8a2d\u3001\u671f\u671b\u3001\u4f30\u8a08\u3001\u9810\u6e2c\u548c\u7406\u89e3\u3002\u9019\u4e9b\u8868\u8ff0\u4e26\u975e\u5c0d\u672a\u4f86\u767c\u5c55\u7684\u4fdd\u8b49\uff0c\u6703\u53d7\u5230\u98a8\u96aa\u3001\u4e0d\u78ba\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u97ff\uff0c\u6709\u4e9b\u4e43\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u7bc4\u570d\uff0c\u96e3\u4ee5\u9810\u8a08\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u5011\u7684\u696d\u52d9\u3001\u7af6\u722d\u74b0\u5883\u3001\u653f\u6cbb\u3001\u7d93\u6fdf\u3001\u6cd5\u5f8b\u548c\u793e\u6703\u60c5\u6cc1\u7684\u672a\u4f86\u8b8a\u5316\u53ca\u767c\u5c55\u7684\u5f71\u97ff\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u6703\u8207\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8cc7\u6599\u6709\u8f03\u5927\u5dee\u5225\u3002<\/p>","protected":false},"excerpt":{"rendered":"

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[1]Jiang, H., Pang, S., Zhang, Y. et al. A phase 1b randomised controlled trial of a glucagon-like peptide-1 and glucagon receptor dual agonist IBI362 (LY3305677) in Chinese patients with type 2 diabetes. Nat Commun 13, 3613 (2022). https:\/\/doi.org\/10.1038\/s41467-022-31328-x [2]Ji L, Jiang H, An P, et al. (2021) IBI362 (LY3305677), a weekly-dose GLP-1 and glucagon receptor dual agonist, in Chinese adults with overweight or obesity: A randomised, placebo-controlled, multiple ascending dose phase 1b study. 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[1]Jiang, H., Pang, S., Zhang, Y. et al. A phase 1b randomised controlled trial of a glucagon-like peptide-1 and glucagon receptor dual agonist IBI362 (LY3305677) in Chinese patients with type 2 diabetes. Nat Commun 13, 3613 (2022). https:\/\/doi.org\/10.1038\/s41467-022-31328-x [2]Ji L, Jiang H, An P, et al. (2021) IBI362 (LY3305677), a weekly-dose GLP-1 and glucagon receptor dual agonist, in Chinese adults with overweight or obesity: A randomised, placebo-controlled, multiple ascending dose phase 1b study. 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[1]Jiang, H., Pang, S., Zhang, Y. et al. A phase 1b randomised controlled trial of a glucagon-like peptide-1 and glucagon receptor dual agonist IBI362 (LY3305677) in Chinese patients with type 2 diabetes. Nat Commun 13, 3613 (2022). https:\/\/doi.org\/10.1038\/s41467-022-31328-x [2]Ji L, Jiang H, An P, et al. (2021) IBI362 (LY3305677), a weekly-dose GLP-1 and glucagon receptor dual agonist, in Chinese adults with overweight or obesity: A randomised, placebo-controlled, multiple ascending dose phase 1b study. 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