{"id":26415,"date":"2025-06-03T01:25:00","date_gmt":"2025-06-02T17:25:00","guid":{"rendered":"https:\/\/www.franchise.com.hk\/%e4%ba%9e%e7%9b%9b%e9%86%ab%e8%97%a5bcl-2%e6%8a%91%e5%88%b6%e5%8a%91lisaftoclax%e9%87%9d%e5%b0%8d%e7%b6%ad%e5%a5%88%e5%85%8b%e6%8b%89%e6%b2%bb%e7%99%82%e5%a4%b1%e6%95%97%e6%82%a3%e8%80%85%e5%8f%a3\/26415"},"modified":"2025-06-03T01:25:00","modified_gmt":"2025-06-02T17:25:00","slug":"%e4%ba%9e%e7%9b%9b%e9%86%ab%e8%97%a5bcl-2%e6%8a%91%e5%88%b6%e5%8a%91lisaftoclax%e9%87%9d%e5%b0%8d%e7%b6%ad%e5%a5%88%e5%85%8b%e6%8b%89%e6%b2%bb%e7%99%82%e5%a4%b1%e6%95%97%e6%82%a3%e8%80%85%e5%8f%a3","status":"publish","type":"post","link":"https:\/\/www.franchise.com.hk\/en\/%e4%ba%9e%e7%9b%9b%e9%86%ab%e8%97%a5bcl-2%e6%8a%91%e5%88%b6%e5%8a%91lisaftoclax%e9%87%9d%e5%b0%8d%e7%b6%ad%e5%a5%88%e5%85%8b%e6%8b%89%e6%b2%bb%e7%99%82%e5%a4%b1%e6%95%97%e6%82%a3%e8%80%85%e5%8f%a3\/26415","title":{"rendered":"\u4e9e\u76db\u91ab\u85e5Bcl-2\u6291\u5236\u5291Lisaftoclax\u91dd\u5c0d\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u5931\u6557\u60a3\u8005\u53e3\u982d\u5831\u544a\u6578\u64da\u5f37\u52c1\uff0c\u5168\u7403\u7af6\u722d\u512a\u52e2\u660e\u986f|\u76f4\u64ca2025 ASCO"},"content":{"rendered":"

\u7f8e\u570b\u99ac\u88e1\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607\u5dde<\/span> 2025\u5e746\u67083\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u81f4\u529b\u65bc\u5728\u816b\u7624\u7b49\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff08\u7d0d\u65af\u9054\u514b\u4ee3\u78bc\uff1aAAPG\uff1b\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a6855\uff09\u5ba3\u5e03\uff0c\u00a0\u516c\u53f8\u5df2\u5728\u7b2c61\u5c46\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\u4e0a\uff0c\u53e3\u982d\u5831\u544a\u4e86\u5728\u7814Bcl-2\u6291\u5236\u5291APG-2575\uff08lisaftoclax\uff09\u806f\u5408\u53bb\u7532\u57fa\u5316\u85e5\u7269\u963f\u624e\u80de\u7518\u6cbb\u7642\u6cbb\u7642\u521d\u6cbb\uff08TN\uff09\u6216\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u7684\u9ad3\u7cfb\u60e1\u6027\u816b\u7624\u60a3\u8005\u7684Ib\/II\u671f\u81e8\u5e8a\u7814\u7a76\u6700\u65b0\u6578\u64da\u3002<\/p>\n

\n<\/div>\n

\u4e00\u5e74\u4e00\u5ea6\u7684ASCO\u5e74\u6703\u662f\u5168\u7403\u816b\u7624\u9818\u57df\u6700\u91cd\u8981\u7684\u3001\u6700\u70ba\u6b0a\u5a01\u7684\u5b78\u8853\u4ea4\u6d41\u76db\u6703\uff0c\u5c07\u5c55\u793a\u7576\u524d\u570b\u969b\u6700\u524d\u6cbf\u7684\u81e8\u5e8a\u816b\u7624\u5b78\u79d1\u7814\u6210\u679c\u548c\u816b\u7624\u6cbb\u7642\u6280\u8853\u3002\u4eca\u5e74\u662f\u4e9e\u76db\u91ab\u85e5\u9023\u7e8c\u7b2c\u516b\u5e74\u4eae\u76f8ASCO\u5e74\u6703\uff0c\u6b64\u6b21\u516c\u53f8\u7d30\u80de\u51cb\u4ea1\u7ba1\u7dda\u91cd\u9ede\u54c1\u7a2elisaftoclax\u548cMDM2-p53\u6291\u5236\u5291APG-115\uff08alrizomadlin\uff09\u5171\u6709\u5169\u9805\u7814\u7a76\u5165\u9078\uff0c\u5176\u4e2d\u4e00\u9805\u7372\u53e3\u982d\u5831\u544a\u3002<\/p>\n

Lisaftoclax\u6b64\u6b21\u53e3\u982d\u5831\u544a\u7814\u7a76\u70ba\u4e00\u9805\u5168\u7403\u591a\u4e2d\u5fc3\u7684Ib\/II\u671f\u7814\u7a76\uff0c\u622a\u81f32025\u5e744\u6708\uff0c\u5171\u5165\u7d44103\u4f8b\u60a3\u8005\uff0c\u5176\u4e2d\u5305\u62ec\u65b0\u8a3a\u65b7\u548c\u5fa9\u767c\/\u96e3\u6cbb\u7684AML\u548cMDS\u60a3\u8005\u3002\u8a72\u7814\u7a76\u6700\u65b0\u9032\u5c55\u518d\u6b21\u9a57\u8b49\u4e86lisaftoclax\u5728\u60e1\u6027\u9ad3\u7cfb\u816b\u7624\u6cbb\u7642\u4e2d\u5353\u8d8a\u7642\u6548\u548c\u5353\u8d8a\u5b89\u5168\u6027\u4e8c\u8005\u517c\u5099\u7684\u7279\u9ede\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u672c\u7814\u7a76\u9996\u6b21\u5831\u544a\u4e86lisaftoclax\u5728\u65e2\u5f80\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u5931\u6557\u7684\u60a3\u8005\u4e2d\u4e5f\u6709\u5f88\u597d\u7684\u6cbb\u7642\u53cd\u61c9\uff0c\u986f\u793a\u51falisaftoclax\u548c\u570b\u5916\u540c\u985e\u7522\u54c1\u7684\u5dee\u7570\u5316\u548c\u7642\u6548\u512a\u52e2\u6f5b\u529b\u3002<\/p>\n

Lisaftoclax\u662f\u4e9e\u76db\u91ab\u85e5\u81ea\u4e3b\u7814\u767c\u7684\u65b0\u578bBcl-2\u9078\u64c7\u6027\u6291\u5236\u5291\uff0c\u5176\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\uff08NDA\uff09\u5df2\u65bc2024\u5e7411\u6708\u7372\u570b\u5bb6\u85e5\u76e3\u5c40\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u53d7\u7406\u4e26\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u7a0b\u5e8f\uff0c\u7528\u65bc\u6cbb\u7642\u5fa9\u767c\/\u96e3\u6cbb\u6027\uff08R\/R\uff09\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\uff0c\u662f\u5168\u7403\u7b2c\u4e8c\u500b\u905e\u4ea4NDA\u7684Bcl-2\u6291\u5236\u5291\u548c\u4e2d\u570b\u9996\u500b\u905e\u4ea4NDA\u4e26\u9032\u5165\u512a\u5148\u5be9\u8a55\u7684\u570b\u7522\u539f\u7814Bcl-2\u6291\u5236\u5291\u3002\u76ee\u524d\uff0cLisaftoclax\u5171\u67094\u9805\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u6b63\u5728\u958b\u5c55\uff0c\u6d89\u53caCLL\/SLL\u3001\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u3001\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\uff08MDS\uff09\u5e7e\u5927\u9069\u61c9\u75c7\uff0c\u4e14\u5176\u4e2d\u4e00\u9805\u70ba\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u8a31\u53ef\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u3002<\/p>\n

\u8a72\u9805\u81e8\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001 \u7f8e\u570b Novant Health \u91ab\u7642\u96c6\u5718\u764c\u75c7\u7814\u7a76\u6240 \uff08 Novant Health Cancer Institute \uff09\u7684 Patricia Kropf \u6559\u6388\u8868\u793a\uff1a\u300c\u672c\u7814\u7a76\u662f\u570b\u969b\u591a\u4e2d\u5fc3\u81e8\u5e8a\u7814\u7a76\uff0clisaftoclax\u806f\u5408\u963f\u624e\u80de\u7518\u5728\u521d\u6cbb\u4ee5\u53ca\u5fa9\u767c\u96e3\u6cbbAML\u3001MDS\u60a3\u8005\u4e2d\uff0c\u5c55\u73fe\u51fa\u4ee4\u4eba\u5370\u8c61\u6df1\u523b\u7684\u7642\u6548\u548c\u53ef\u63a7\u7684\u5b89\u5168\u6027\u3002\u9019\u4e9b\u6578\u64da\u70ba\u5373\u5c07\u958b\u5c55\u7684\u8a72\u806f\u5408\u7642\u6cd5\u6cbb\u7642\u9019\u4e00\u60a3\u8005\u7fa4\u9ad4\u7684III\u671f\u7814\u7a76\u63d0\u4f9b\u4e86\u652f\u6301\u3002\u7279\u5225\u503c\u5f97\u6307\u51fa\u7684\u662f\uff0clisaftoclax\u5728\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u5931\u6557\u7684\u60a3\u8005\u4e2d\uff0c\u5c55\u73fe\u51fa\u514b\u670d\u7dad\u5948\u514b\u62c9\u8010\u85e5\u7684\u6f5b\u529b\uff0c\u9019\u500b\u4ee4\u4eba\u8208\u596e\u7684\u65b0\u767c\u73fe\uff0c\u8868\u660elisaftoclax\u6709\u671b\u6539\u5584\u60a3\u8005\u7684\u6cbb\u7642\u6548\u679c\u3002\u6211\u5011\u671f\u5f85\u5f8c\u7e8c\u66f4\u591a\u7684\u81e8\u5e8a\u7814\u7a76\u6578\u64da\uff0c\u9032\u4e00\u6b65\u8b49\u660elisaftoclax\u5ee3\u6cdb\u7684\u81e8\u5e8a\u61c9\u7528\u524d\u666f\u3002\u300d<\/p>\n

\u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300cLisaftoclax\u806f\u5408\u963f\u624e\u80de\u7518\u5df2\u5728\u65e2\u5f80\u7814\u7a76\u4e2d\u5448\u73fe\u51fa\u6cbb\u7642\u591a\u7a2e\u9ad3\u7cfb\u60e1\u6027\u816b\u7624\u60a3\u8005\u7684\u5f37\u52c1\u6f5b\u529b\u3002\u6b64\u6b21\u53e3\u982d\u5831\u544a\u7684\u9019\u9805\u5168\u7403\u591a\u4e2d\u5fc3\u7684Ib\/II\u671f\u81e8\u5e8a\u7814\u7a76\u6700\u65b0\u9032\u5c55\u518d\u6b21\u8868\u660e\uff0c\u8a72\u54c1\u7a2e\u806f\u5408\u6cbb\u7642\u5728AML\u3001MDS\u7b49\u9ad3\u7cfb\u60e1\u6027\u816b\u7624\u60a3\u8005\u4e2d\uff0c\u5177\u6709\u826f\u597d\u7684\u6297\u816b\u7624\u6d3b\u6027\u548c\u8010\u53d7\u6027\u3002\u7279\u5225\u503c\u5f97\u95dc\u6ce8\u7684\u662f\uff0clisaftoclax\u5c0d\u65bc\u65e2\u5f80\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u5931\u6557\u7684\u60a3\u8005\u6709\u660e\u986f\u6cbb\u7642\u6f5b\u529b\uff0c\u9019\u662f\u570b\u969b\u4e0a\u9996\u6b21\u5831\u544a\u4e00\u7a2eBcl-2\u6291\u5236\u5291\u514b\u670d\u53e6\u4e00\u7a2eBcl-2\u6291\u5236\u5291\u8010\u85e5\u7684\u81e8\u5e8a\u7814\u7a76\uff0c\u610f\u5473\u8457lisaftoclax\u6709\u671b\u5728\u9ad3\u7cfb\u60e1\u6027\u816b\u7624\u6cbb\u7642\u9818\u57df\u5e36\u4f86\u65b0\u7684\u7a81\u7834\u3002\u5728AML\u548cMDS\u9069\u61c9\u75c7\u9818\u57df\uff0clisaftoclax\u5df2\u7d93\u6709\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u6b63\u5728\u958b\u5c55\u3002\u6211\u5011\u5c07\u5805\u5b88’\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42’\u9019\u4e00\u4f7f\u547d\uff0c\u52a0\u5feb\u81e8\u5e8a\u958b\u767c\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002\u300d<\/p>\n

\u5728\u6b64\u6b21ASCO\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u8a72\u81e8\u5e8a\u7814\u7a76\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a<\/p>\n

Phase 1b\/2 Study of Lisaftoclax (APG-2575) Combined with Azacitidine (AZA) in Patients w ith Treatment- N a\u00efve or Prior Venetoclax- E xposed Myeloid Malignancies\u00a0
\u4e00\u9805\u8a55\u4f30 APG-2575 \uff08 Lisaftoclax \uff09\u806f\u5408\u963f\u624e\u80de\u7518\uff08 AZA \uff09\u6cbb\u7642\u521d\u6cbb\uff08 TN \uff09\u6216\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\uff08 VEN \uff09\u6cbb\u7642\u7684\u9ad3\u7cfb\u60e1\u6027\u816b\u7624\u60a3\u8005\uff08 Pts \uff09\u7684 Ib\/II \u671f\u81e8\u5e8a\u7814\u7a76 <\/p>\n

\u6458\u8981\u7de8\u865f\uff1a6505 \u5c55\u793a\u5f62\u5f0f\uff1a\u53e3\u982d\u5831\u544a \u5206\u6703\u5834\u6a19\u984c\uff1a\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u2013\u767d\u8840\u75c5\u3001\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\u53ca\u540c\u7a2e\u7570\u9ad4\u79fb\u690d\uff08Hematologic Malignancies\u2014Leukemia, Myelodysplastic Syndromes, and Allotransplant\uff09 \u4e3b\u8981\u4f5c\u8005\uff1a\u6fb3\u5927\u5229\u4e9e\u7687\u5bb6\u73c0\u65af\u91ab\u9662\uff08Royal Perth Hospital\uff09Michael Francis Leahy\uff1b\u6fb3\u5927\u5229\u4e9e\u963f\u723e\u5f17\u96f7\u5fb7\u91ab\u9662\uff08The Alfred Hospital\uff09\u3001\u6fb3\u5927\u5229\u4e9e\u8840\u6db2\u75c5\u4e2d\u5fc3\uff08Australian Centre for Blood Diseases\uff09Shaun Fleming\u535a\u58eb\uff1b\u7f8e\u570bNovant Health\u91ab\u7642\u96c6\u5718\u764c\u75c7\u7814\u7a76\u6240\uff08Novant Health Cancer Institute\uff09Patricia Kropf\u535a\u58eb\u7b49 \u6838\u5fc3\u8981\u9ede\uff1a
\u7814\u7a76\u80cc\u666f\uff1a
– AML\u548cMDS\u662f\u9810\u5f8c\u8f03\u5dee\u7684\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u3002
– \u53bb\u7532\u57fa\u5316\u85e5\u7269\uff08HMAs\uff09AZA\u548c\u5730\u897f\u4ed6\u6ff1\u5df2\u88ab\u6279\u51c6\u7528\u65bc\u6cbb\u7642MDS\u548cAML\uff0c\u4e26\u5df2\u8b49\u660e\u53ef\u5ef6\u9577\u60a3\u8005\u7684\u751f\u5b58\u671f\u3002\u7136\u800c\uff0c\u9084\u9700\u8981\u66f4\u591a\u7684\u6cbb\u7642\u65b9\u6848\u4f86\u6539\u5584\u81e8\u5e8a\u7642\u6548\uff0c\u5982\u5b8c\u5168\u7de9\u89e3\uff08CR\uff09\u548c\u7e3d\u751f\u5b58\u671f\uff08OS\uff09\u3002
– Lisaftoclax\u662f\u4e00\u7a2e\u5728\u7814\u7684\u53e3\u670d\u5c0f\u5206\u5b50Bcl-2\u6291\u5236\u5291\uff0c\u5df2\u5728\u81e8\u5e8a\u524d[1]\u548c\u81e8\u5e8a[2]\u7814\u7a76\u4e2d\u986f\u793a\u5176\u8207\u00a0AZA \u806f\u7528\u53ef\u589e\u5f37\u5c0d\u00a0AML \u548c\u00a0MDS \u7684\u6cbb\u7642\u6548\u679c\u3002
\u7642\u6548\u6578\u64da\uff1a
– \u622a\u81f32025\u5e744\u6708\uff0c\u572828\u4f8b\u65e2\u5f80\u7dad\u5948\u514b\u62c9\u8010\u85e5\u7684\u5fa9\u767c\/\u96e3\u6cbb AML\/\u6df7\u5408\u8868\u578b\u6025\u6027\u767d\u8840\u75c5\uff08MPAL\uff09\u60a3\u8005\u4e2d\uff0c\u7642\u6548\u53ef\u8a55\u4f30\u7684\u60a3\u8005\u670922\u4f8b\uff0c\u7e3d\u53cd\u61c9\u7387\uff08ORR\uff09\u70ba31.8%\uff087\/22\uff09\uff0c\u5176\u4e2d22.8%\u7684\u60a3\u8005CR\/ CR\u4f34\u8840\u7d30\u80de\u672a\u5b8c\u5168\u6062\u5fa9\uff08Cri\uff09\uff1b4.6% \u7684\u60a3\u8005\u7372\u90e8\u5206\u7de9\u89e3\uff08PR\uff09\uff1b4.6%\u7684\u60a3\u8005\u7372\u5f62\u614b\u5b78\u7121\u767d\u8840\u75c5\u72c0\u614b\uff08MLFS\uff09\u3002\u7372\u5f97\u6cbb\u7642\u53cd\u61c9\u7684\u60a3\u8005\u65e2\u5f80\u5747\u63a5\u53d7\u904e\u5305\u62ec\u7dad\u5948\u514b\u62c9\u5728\u5167\u7684\u591a\u7dda\u6cbb\u7642\uff0c\u4e14\u5927\u90e8\u5206\uff0871%\uff0c5\/7\uff09\u60a3\u8005\u57fa\u7dda\u5b58\u5728TP53\u7a81\u8b8a\u4e26\u4f34\u96a8\u5fa9\u96dc\u67d3\u8272\u9ad4\u6838\u578b\u3002
– \u57286\u4f8b\u7642\u6548\u53ef\u8a55\u4f30\u7684\u65b0\u8a3a\u65b7\uff08ND\uff09AML\/ MPAL\u60a3\u8005\u4e2d\uff0cORR\u70ba 83.3%, \u5176\u4e2d33.3%\u7684\u60a3\u8005\u7372 CR\/CRi \uff0c50%\u7684\u60a3\u8005\u7372PR\u3002\u5728 44 \u4f8b\u7642\u6548\u53ef\u8a55\u4f30R\/R AML\/MPAL \u60a3\u8005\u4e2d\uff0cORR\u70ba 43.2%\uff0c\u5176\u4e2d31.8% \u7684\u60a3\u8005\u7372CR\/CRi \uff0c4.5%\u7684\u60a3\u8005\u7372PR\uff0c6.8% \u7684\u60a3\u8005\u7372MLFS\u3002
– \u572815\u4f8b\u7642\u6548\u53ef\u8a55\u4f30\u7684 ND MDS\/\u6162\u6027\u7c92\u55ae\u6838\u7d30\u80de\u767d\u8840\u75c5\uff08CMML\uff09\u60a3\u8005\u4e2d\uff0cORR\u70ba 80%\uff0c\u5176\u4e2d40%\u7684\u60a3\u8005\u7372CR\uff0c40%\u7684\u60a3\u8005\u7372\u9aa8\u9ad3CR\uff08mCR\uff09\u300222 \u4f8b\u7642\u6548\u53ef\u8a55\u4f30\u7684 R\/R MDS\/CMML \u60a3\u8005\u4e2d\uff0cORR\u70ba 50%\uff0c\u5176\u4e2d27.3%\u7684\u60a3\u8005\u7372 CR\uff0c18.2%\u7684\u60a3\u8005\u7372 mCR\uff0c4.5%\u7684\u60a3\u8005\u7372PR\u3002 <\/p>\n

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\u7e3d\u7d50\uff1a\u00a0Lisaftoclax\u806f\u5408AZA\u6cbb\u7642TN\u6216\u5fa9\u767c\/\u96e3\u6cbb\u9ad3\u7cfb\u60e1\u6027\u816b\u7624\u60a3\u8005\uff0c\u5c55\u73fe\u51fa\u51fa\u8272\u7684\u81e8\u5e8a\u7642\u6548\u4ee5\u53ca\u5b89\u5168\u6027\u3002\u7279\u5225\u662f\uff0clisaftoclax\u5c55\u793a\u51fa\u514b\u670d\u7dad\u5948\u514b\u62c9\u8010\u85e5\u7684\u6f5b\u529b\uff0c\u662f\u570b\u969b\u4e0a\u9996\u6b21\u5831\u544a\u65b0\u578bBcl-2\u6291\u5236\u5291\u514b\u670d\u7dad\u5948\u514b\u62c9\u8010\u85e5\u7684\u81e8\u5e8a\u7814\u7a76\u3002<\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a <\/p>\n

[1]Zhai Y, Tang Q, Fang DD, et al. Lisaftoclax in Combination with Alrizomadlin Overcomes Venetoclax Resistance in Acute Myeloid Leukemia and Acute Lymphoblastic Leukemia: Preclinical Studies. Clin Cancer Res. 2023;29:183-196. https:\/\/doi.org\/10.1158\/1078-0432.CCR-22-0978<\/a>
[2]Wang H, Wei X, Jiang Q, et al. Safety and Efficacy of Lisaftoclax (APG-2575), a Novel BCL-2 Inhibitor (BCL-2i), in Relapsed or Refractory (R\/R) or Treatment-Na\u00efve (TN) Patients (Pts) with Acute Myeloid leukemia (AML), Myelodysplastic Syndrome (MDS), or Other Myeloid Neoplasms. Blood 2023;142(Suppl 1):2925. https:\/\/doi.org\/10.1182\/blood-2023-188489<\/a><\/p>\n

\u95dc\u65bc\u4e9e\u76db\u91ab\u85e5 <\/p>\n

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\u524d\u77bb\u6027\u8072\u660e <\/p>\n

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\u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300cLisaftoclax\u806f\u5408\u963f\u624e\u80de\u7518\u5df2\u5728\u65e2\u5f80\u7814\u7a76\u4e2d\u5448\u73fe\u51fa\u6cbb\u7642\u591a\u7a2e\u9ad3\u7cfb\u60e1\u6027\u816b\u7624\u60a3\u8005\u7684\u5f37\u52c1\u6f5b\u529b\u3002\u6b64\u6b21\u53e3\u982d\u5831\u544a\u7684\u9019\u9805\u5168\u7403\u591a\u4e2d\u5fc3\u7684Ib\/II\u671f\u81e8\u5e8a\u7814\u7a76\u6700\u65b0\u9032\u5c55\u518d\u6b21\u8868\u660e\uff0c\u8a72\u54c1\u7a2e\u806f\u5408\u6cbb\u7642\u5728AML\u3001MDS\u7b49\u9ad3\u7cfb\u60e1\u6027\u816b\u7624\u60a3\u8005\u4e2d\uff0c\u5177\u6709\u826f\u597d\u7684\u6297\u816b\u7624\u6d3b\u6027\u548c\u8010\u53d7\u6027\u3002\u7279\u5225\u503c\u5f97\u95dc\u6ce8\u7684\u662f\uff0clisaftoclax\u5c0d\u65bc\u65e2\u5f80\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u5931\u6557\u7684\u60a3\u8005\u6709\u660e\u986f\u6cbb\u7642\u6f5b\u529b\uff0c\u9019\u662f\u570b\u969b\u4e0a\u9996\u6b21\u5831\u544a\u4e00\u7a2eBcl-2\u6291\u5236\u5291\u514b\u670d\u53e6\u4e00\u7a2eBcl-2\u6291\u5236\u5291\u8010\u85e5\u7684\u81e8\u5e8a\u7814\u7a76\uff0c\u610f\u5473\u8457lisaftoclax\u6709\u671b\u5728\u9ad3\u7cfb\u60e1\u6027\u816b\u7624\u6cbb\u7642\u9818\u57df\u5e36\u4f86\u65b0\u7684\u7a81\u7834\u3002\u5728AML\u548cMDS\u9069\u61c9\u75c7\u9818\u57df\uff0clisaftoclax\u5df2\u7d93\u6709\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u6b63\u5728\u958b\u5c55\u3002\u6211\u5011\u5c07\u5805\u5b88’\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42’\u9019\u4e00\u4f7f\u547d\uff0c\u52a0\u5feb\u81e8\u5e8a\u958b\u767c\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002\u300d \u5728\u6b64\u6b21ASCO\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u8a72\u81e8\u5e8a\u7814\u7a76\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a Phase 1b\/2 Study of Lisaftoclax (APG-2575) Combined with Azacitidine (AZA) in Patients w ith Treatment- N a\u00efve or Prior Venetoclax- E xposed Myeloid Malignancies\u00a0 \u4e00\u9805\u8a55\u4f30 APG-2575 \uff08 Lisaftoclax \uff09\u806f\u5408\u963f\u624e\u80de\u7518\uff08 AZA \uff09\u6cbb\u7642\u521d\u6cbb\uff08 TN \uff09\u6216\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\uff08 VEN \uff09\u6cbb\u7642\u7684\u9ad3\u7cfb\u60e1\u6027\u816b\u7624\u60a3\u8005\uff08 Pts \uff09\u7684 Ib\/II \u671f\u81e8\u5e8a\u7814\u7a76 \u6458\u8981\u7de8\u865f\uff1a6505 \u5c55\u793a\u5f62\u5f0f\uff1a\u53e3\u982d\u5831\u544a \u5206\u6703\u5834\u6a19\u984c\uff1a\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u2013\u767d\u8840\u75c5\u3001\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\u53ca\u540c\u7a2e\u7570\u9ad4\u79fb\u690d\uff08Hematologic Malignancies\u2014Leukemia, Myelodysplastic Syndromes, and Allotransplant\uff09 \u4e3b\u8981\u4f5c\u8005\uff1a\u6fb3\u5927\u5229\u4e9e\u7687\u5bb6\u73c0\u65af\u91ab\u9662\uff08Royal Perth Hospital\uff09Michael Francis Leahy\uff1b\u6fb3\u5927\u5229\u4e9e\u963f\u723e\u5f17\u96f7\u5fb7\u91ab\u9662\uff08The Alfred Hospital\uff09\u3001\u6fb3\u5927\u5229\u4e9e\u8840\u6db2\u75c5\u4e2d\u5fc3\uff08Australian Centre for Blood Diseases\uff09Shaun Fleming\u535a\u58eb\uff1b\u7f8e\u570bNovant Health\u91ab\u7642\u96c6\u5718\u764c\u75c7\u7814\u7a76\u6240\uff08Novant Health Cancer Institute\uff09Patricia Kropf\u535a\u58eb\u7b49 \u6838\u5fc3\u8981\u9ede\uff1a \u7814\u7a76\u80cc\u666f\uff1a– AML\u548cMDS\u662f\u9810\u5f8c\u8f03\u5dee\u7684\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u3002– \u53bb\u7532\u57fa\u5316\u85e5\u7269\uff08HMAs\uff09AZA\u548c\u5730\u897f\u4ed6\u6ff1\u5df2\u88ab\u6279\u51c6\u7528\u65bc\u6cbb\u7642MDS\u548cAML\uff0c\u4e26\u5df2\u8b49\u660e\u53ef\u5ef6\u9577\u60a3\u8005\u7684\u751f\u5b58\u671f\u3002\u7136\u800c\uff0c\u9084\u9700\u8981\u66f4\u591a\u7684\u6cbb\u7642\u65b9\u6848\u4f86\u6539\u5584\u81e8\u5e8a\u7642\u6548\uff0c\u5982\u5b8c\u5168\u7de9\u89e3\uff08CR\uff09\u548c\u7e3d\u751f\u5b58\u671f\uff08OS\uff09\u3002– Lisaftoclax\u662f\u4e00\u7a2e\u5728\u7814\u7684\u53e3\u670d\u5c0f\u5206\u5b50Bcl-2\u6291\u5236\u5291\uff0c\u5df2\u5728\u81e8\u5e8a\u524d[1]\u548c\u81e8\u5e8a[2]\u7814\u7a76\u4e2d\u986f\u793a\u5176\u8207\u00a0AZA \u806f\u7528\u53ef\u589e\u5f37\u5c0d\u00a0AML \u548c\u00a0MDS \u7684\u6cbb\u7642\u6548\u679c\u3002\u7642\u6548\u6578\u64da\uff1a– \u622a\u81f32025\u5e744\u6708\uff0c\u572828\u4f8b\u65e2\u5f80\u7dad\u5948\u514b\u62c9\u8010\u85e5\u7684\u5fa9\u767c\/\u96e3\u6cbb AML\/\u6df7\u5408\u8868\u578b\u6025\u6027\u767d\u8840\u75c5\uff08MPAL\uff09\u60a3\u8005\u4e2d\uff0c\u7642\u6548\u53ef\u8a55\u4f30\u7684\u60a3\u8005\u670922\u4f8b\uff0c\u7e3d\u53cd\u61c9\u7387\uff08ORR\uff09\u70ba31.8%\uff087\/22\uff09\uff0c\u5176\u4e2d22.8%\u7684\u60a3\u8005CR\/ CR\u4f34\u8840\u7d30\u80de\u672a\u5b8c\u5168\u6062\u5fa9\uff08Cri\uff09\uff1b4.6% \u7684\u60a3\u8005\u7372\u90e8\u5206\u7de9\u89e3\uff08PR\uff09\uff1b4.6%\u7684\u60a3\u8005\u7372\u5f62\u614b\u5b78\u7121\u767d\u8840\u75c5\u72c0\u614b\uff08MLFS\uff09\u3002\u7372\u5f97\u6cbb\u7642\u53cd\u61c9\u7684\u60a3\u8005\u65e2\u5f80\u5747\u63a5\u53d7\u904e\u5305\u62ec\u7dad\u5948\u514b\u62c9\u5728\u5167\u7684\u591a\u7dda\u6cbb\u7642\uff0c\u4e14\u5927\u90e8\u5206\uff0871%\uff0c5\/7\uff09\u60a3\u8005\u57fa\u7dda\u5b58\u5728TP53\u7a81\u8b8a\u4e26\u4f34\u96a8\u5fa9\u96dc\u67d3\u8272\u9ad4\u6838\u578b\u3002– \u57286\u4f8b\u7642\u6548\u53ef\u8a55\u4f30\u7684\u65b0\u8a3a\u65b7\uff08ND\uff09AML\/ MPAL\u60a3\u8005\u4e2d\uff0cORR\u70ba 83.3%, \u5176\u4e2d33.3%\u7684\u60a3\u8005\u7372 CR\/CRi \uff0c50%\u7684\u60a3\u8005\u7372PR\u3002\u5728 44 \u4f8b\u7642\u6548\u53ef\u8a55\u4f30R\/R AML\/MPAL \u60a3\u8005\u4e2d\uff0cORR\u70ba 43.2%\uff0c\u5176\u4e2d31.8% \u7684\u60a3\u8005\u7372CR\/CRi \uff0c4.5%\u7684\u60a3\u8005\u7372PR\uff0c6.8% \u7684\u60a3\u8005\u7372MLFS\u3002– \u572815\u4f8b\u7642\u6548\u53ef\u8a55\u4f30\u7684 ND MDS\/\u6162\u6027\u7c92\u55ae\u6838\u7d30\u80de\u767d\u8840\u75c5\uff08CMML\uff09\u60a3\u8005\u4e2d\uff0cORR\u70ba 80%\uff0c\u5176\u4e2d40%\u7684\u60a3\u8005\u7372CR\uff0c40%\u7684\u60a3\u8005\u7372\u9aa8\u9ad3CR\uff08mCR\uff09\u300222 \u4f8b\u7642\u6548\u53ef\u8a55\u4f30\u7684 R\/R MDS\/CMML \u60a3\u8005\u4e2d\uff0cORR\u70ba 50%\uff0c\u5176\u4e2d27.3%\u7684\u60a3\u8005\u7372 CR\uff0c18.2%\u7684\u60a3\u8005\u7372 mCR\uff0c4.5%\u7684\u60a3\u8005\u7372PR\u3002 \u5b89\u5168\u6027\u6578\u64da\uff1aLisaftoclax\u806f\u5408AZA\u6cbb\u7642\uff0c\u8010\u53d7\u6027\u826f\u597d\uff0c\u5b89\u5168\u6027\u53ef\u63a7\uff0c\u5e38\u898b\u4e0d\u826f\u53cd\u61c9\u4e3b\u8981\u9ad4\u73fe\u5728\u8840\u6db2\u5b78\u4e8b\u4ef6\uff0c\u975e\u8840\u6db2\u5b78\u6bd2\u6027\u4e0d\u5e38\u898b\u3002\u7d55\u5927\u591a\u6578\u4e0d\u826f\u4e8b\u4ef6\u90fd\u53ef\u63a7\u5236\u3001\u53ef\u6062\u5fa9\u3001\u53ef\u8010\u53d7\u3002 \u7e3d\u7d50\uff1a\u00a0Lisaftoclax\u806f\u5408AZA\u6cbb\u7642TN\u6216\u5fa9\u767c\/\u96e3\u6cbb\u9ad3\u7cfb\u60e1\u6027\u816b\u7624\u60a3\u8005\uff0c\u5c55\u73fe\u51fa\u51fa\u8272\u7684\u81e8\u5e8a\u7642\u6548\u4ee5\u53ca\u5b89\u5168\u6027\u3002\u7279\u5225\u662f\uff0clisaftoclax\u5c55\u793a\u51fa\u514b\u670d\u7dad\u5948\u514b\u62c9\u8010\u85e5\u7684\u6f5b\u529b\uff0c\u662f\u570b\u969b\u4e0a\u9996\u6b21\u5831\u544a\u65b0\u578bBcl-2\u6291\u5236\u5291\u514b\u670d\u7dad\u5948\u514b\u62c9\u8010\u85e5\u7684\u81e8\u5e8a\u7814\u7a76\u3002 \u53c3\u8003\u8cc7\u6599\uff1a [1]Zhai Y, Tang Q, Fang DD, et al. Lisaftoclax in Combination with Alrizomadlin Overcomes Venetoclax Resistance in Acute Myeloid Leukemia and Acute Lymphoblastic Leukemia: Preclinical Studies. Clin Cancer Res. 2023;29:183-196. https:\/\/doi.org\/10.1158\/1078-0432.CCR-22-0978[2]Wang H, Wei X, Jiang Q, et al. Safety and Efficacy of Lisaftoclax (APG-2575), a Novel BCL-2 Inhibitor (BCL-2i), in Relapsed or Refractory (R\/R) or Treatment-Na\u00efve (TN) Patients (Pts) with Acute Myeloid leukemia (AML), Myelodysplastic Syndrome (MDS), or Other Myeloid Neoplasms. Blood 2023;142(Suppl 1):2925. https:\/\/doi.org\/10.1182\/blood-2023-188489 \u95dc\u65bc\u4e9e\u76db\u91ab\u85e5 \u4e9e\u76db\u91ab\u85e5\u662f\u4e00\u5bb6\u7d9c\u5408\u6027\u7684\u5168\u7403\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u7814\u767c\u5275\u65b0\u85e5\uff0c\u4ee5\u89e3\u6c7a\u816b\u7624\u7b49\u9818\u57df\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u30022019\u5e7410\u670828\u65e5\uff0c\u516c\u53f8\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e3b\u677f\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6855.HK\uff1b2025\u5e741\u670824\u65e5\uff0c\u516c\u53f8\u5728\u7f8e\u570b\u7d0d\u65af\u9054\u514b\u8b49\u5238\u4ea4\u6613\u6240\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1aAAPG\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u5efa\u7acb\u8c50\u5bcc\u7684\u5275\u65b0\u85e5\u7522\u54c1\u7ba1\u7dda\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u548c\u00a0MDM2-p53 \u7b49\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u7684\u6291\u5236\u5291\uff1b\u65b0\u4e00\u4ee3\u91dd\u5c0d\u764c\u75c7\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u6fc0\u9176\u7a81\u8b8a\u9ad4\u7684\u6291\u5236\u5291\u7b49\u3002 \u516c\u53f8\u6838\u5fc3\u54c1\u7a2e\u8010\u7acb\u514b\u00ae\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5291\uff0c\u4e14\u7372\u6279\u9069\u61c9\u75c7\u5747\u88ab\u6210\u529f\u7d0d\u5165\u570b\u5bb6\u91ab\u4fdd\u85e5\u54c1\u76ee\u9304\uff0c\u76ee\u524d\uff0c\u4e9e\u76db\u91ab\u85e5\u6b63\u5728\u958b\u5c55\u8010\u7acb\u514b\u00ae\u4e00\u9805\u7372\u7f8e\u570bFDA\u8a31\u53ef\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff08POLARIS-2\uff09\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u6cbb\u7642\u7684\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u6162\u6027\u671f\uff08CML-CP\uff09\u6210\u5e74\u60a3\u8005\u3002\u6b64\u5916\uff0c\u8010\u7acb\u514b\u00ae\u806f\u5408\u6cbb\u7642\u65b0\u8a3a\u65b7\u8cbb\u57ce\u67d3\u8272\u9ad4\u967d\u6027\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08Ph+ 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\u5728\u6b64\u6b21ASCO\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u8a72\u81e8\u5e8a\u7814\u7a76\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a Phase 1b\/2 Study of Lisaftoclax (APG-2575) Combined with Azacitidine (AZA) in Patients w ith Treatment- N a\u00efve or Prior Venetoclax- E xposed Myeloid Malignancies\u00a0 \u4e00\u9805\u8a55\u4f30 APG-2575 \uff08 Lisaftoclax \uff09\u806f\u5408\u963f\u624e\u80de\u7518\uff08 AZA \uff09\u6cbb\u7642\u521d\u6cbb\uff08 TN \uff09\u6216\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\uff08 VEN \uff09\u6cbb\u7642\u7684\u9ad3\u7cfb\u60e1\u6027\u816b\u7624\u60a3\u8005\uff08 Pts \uff09\u7684 Ib\/II \u671f\u81e8\u5e8a\u7814\u7a76 \u6458\u8981\u7de8\u865f\uff1a6505 \u5c55\u793a\u5f62\u5f0f\uff1a\u53e3\u982d\u5831\u544a \u5206\u6703\u5834\u6a19\u984c\uff1a\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u2013\u767d\u8840\u75c5\u3001\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\u53ca\u540c\u7a2e\u7570\u9ad4\u79fb\u690d\uff08Hematologic Malignancies\u2014Leukemia, Myelodysplastic Syndromes, and Allotransplant\uff09 \u4e3b\u8981\u4f5c\u8005\uff1a\u6fb3\u5927\u5229\u4e9e\u7687\u5bb6\u73c0\u65af\u91ab\u9662\uff08Royal Perth Hospital\uff09Michael Francis Leahy\uff1b\u6fb3\u5927\u5229\u4e9e\u963f\u723e\u5f17\u96f7\u5fb7\u91ab\u9662\uff08The Alfred Hospital\uff09\u3001\u6fb3\u5927\u5229\u4e9e\u8840\u6db2\u75c5\u4e2d\u5fc3\uff08Australian Centre for Blood Diseases\uff09Shaun Fleming\u535a\u58eb\uff1b\u7f8e\u570bNovant Health\u91ab\u7642\u96c6\u5718\u764c\u75c7\u7814\u7a76\u6240\uff08Novant Health Cancer Institute\uff09Patricia Kropf\u535a\u58eb\u7b49 \u6838\u5fc3\u8981\u9ede\uff1a \u7814\u7a76\u80cc\u666f\uff1a– AML\u548cMDS\u662f\u9810\u5f8c\u8f03\u5dee\u7684\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u3002– 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\u53c3\u8003\u8cc7\u6599\uff1a [1]Zhai Y, Tang Q, Fang DD, et al. Lisaftoclax in Combination with Alrizomadlin Overcomes Venetoclax Resistance in Acute Myeloid Leukemia and Acute Lymphoblastic Leukemia: Preclinical Studies. Clin Cancer Res. 2023;29:183-196. https:\/\/doi.org\/10.1158\/1078-0432.CCR-22-0978[2]Wang H, Wei X, Jiang Q, et al. Safety and Efficacy of Lisaftoclax (APG-2575), a Novel BCL-2 Inhibitor (BCL-2i), in Relapsed or Refractory (R\/R) or Treatment-Na\u00efve (TN) Patients (Pts) with Acute Myeloid leukemia (AML), Myelodysplastic Syndrome (MDS), or Other Myeloid Neoplasms. Blood 2023;142(Suppl 1):2925. https:\/\/doi.org\/10.1182\/blood-2023-188489 \u95dc\u65bc\u4e9e\u76db\u91ab\u85e5 \u4e9e\u76db\u91ab\u85e5\u662f\u4e00\u5bb6\u7d9c\u5408\u6027\u7684\u5168\u7403\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u7814\u767c\u5275\u65b0\u85e5\uff0c\u4ee5\u89e3\u6c7a\u816b\u7624\u7b49\u9818\u57df\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u30022019\u5e7410\u670828\u65e5\uff0c\u516c\u53f8\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e3b\u677f\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6855.HK\uff1b2025\u5e741\u670824\u65e5\uff0c\u516c\u53f8\u5728\u7f8e\u570b\u7d0d\u65af\u9054\u514b\u8b49\u5238\u4ea4\u6613\u6240\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1aAAPG\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u5efa\u7acb\u8c50\u5bcc\u7684\u5275\u65b0\u85e5\u7522\u54c1\u7ba1\u7dda\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u548c\u00a0MDM2-p53 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\u6559\u6388\u8868\u793a\uff1a\u300c\u672c\u7814\u7a76\u662f\u570b\u969b\u591a\u4e2d\u5fc3\u81e8\u5e8a\u7814\u7a76\uff0clisaftoclax\u806f\u5408\u963f\u624e\u80de\u7518\u5728\u521d\u6cbb\u4ee5\u53ca\u5fa9\u767c\u96e3\u6cbbAML\u3001MDS\u60a3\u8005\u4e2d\uff0c\u5c55\u73fe\u51fa\u4ee4\u4eba\u5370\u8c61\u6df1\u523b\u7684\u7642\u6548\u548c\u53ef\u63a7\u7684\u5b89\u5168\u6027\u3002\u9019\u4e9b\u6578\u64da\u70ba\u5373\u5c07\u958b\u5c55\u7684\u8a72\u806f\u5408\u7642\u6cd5\u6cbb\u7642\u9019\u4e00\u60a3\u8005\u7fa4\u9ad4\u7684III\u671f\u7814\u7a76\u63d0\u4f9b\u4e86\u652f\u6301\u3002\u7279\u5225\u503c\u5f97\u6307\u51fa\u7684\u662f\uff0clisaftoclax\u5728\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u5931\u6557\u7684\u60a3\u8005\u4e2d\uff0c\u5c55\u73fe\u51fa\u514b\u670d\u7dad\u5948\u514b\u62c9\u8010\u85e5\u7684\u6f5b\u529b\uff0c\u9019\u500b\u4ee4\u4eba\u8208\u596e\u7684\u65b0\u767c\u73fe\uff0c\u8868\u660elisaftoclax\u6709\u671b\u6539\u5584\u60a3\u8005\u7684\u6cbb\u7642\u6548\u679c\u3002\u6211\u5011\u671f\u5f85\u5f8c\u7e8c\u66f4\u591a\u7684\u81e8\u5e8a\u7814\u7a76\u6578\u64da\uff0c\u9032\u4e00\u6b65\u8b49\u660elisaftoclax\u5ee3\u6cdb\u7684\u81e8\u5e8a\u61c9\u7528\u524d\u666f\u3002\u300d \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300cLisaftoclax\u806f\u5408\u963f\u624e\u80de\u7518\u5df2\u5728\u65e2\u5f80\u7814\u7a76\u4e2d\u5448\u73fe\u51fa\u6cbb\u7642\u591a\u7a2e\u9ad3\u7cfb\u60e1\u6027\u816b\u7624\u60a3\u8005\u7684\u5f37\u52c1\u6f5b\u529b\u3002\u6b64\u6b21\u53e3\u982d\u5831\u544a\u7684\u9019\u9805\u5168\u7403\u591a\u4e2d\u5fc3\u7684Ib\/II\u671f\u81e8\u5e8a\u7814\u7a76\u6700\u65b0\u9032\u5c55\u518d\u6b21\u8868\u660e\uff0c\u8a72\u54c1\u7a2e\u806f\u5408\u6cbb\u7642\u5728AML\u3001MDS\u7b49\u9ad3\u7cfb\u60e1\u6027\u816b\u7624\u60a3\u8005\u4e2d\uff0c\u5177\u6709\u826f\u597d\u7684\u6297\u816b\u7624\u6d3b\u6027\u548c\u8010\u53d7\u6027\u3002\u7279\u5225\u503c\u5f97\u95dc\u6ce8\u7684\u662f\uff0clisaftoclax\u5c0d\u65bc\u65e2\u5f80\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u5931\u6557\u7684\u60a3\u8005\u6709\u660e\u986f\u6cbb\u7642\u6f5b\u529b\uff0c\u9019\u662f\u570b\u969b\u4e0a\u9996\u6b21\u5831\u544a\u4e00\u7a2eBcl-2\u6291\u5236\u5291\u514b\u670d\u53e6\u4e00\u7a2eBcl-2\u6291\u5236\u5291\u8010\u85e5\u7684\u81e8\u5e8a\u7814\u7a76\uff0c\u610f\u5473\u8457lisaftoclax\u6709\u671b\u5728\u9ad3\u7cfb\u60e1\u6027\u816b\u7624\u6cbb\u7642\u9818\u57df\u5e36\u4f86\u65b0\u7684\u7a81\u7834\u3002\u5728AML\u548cMDS\u9069\u61c9\u75c7\u9818\u57df\uff0clisaftoclax\u5df2\u7d93\u6709\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u6b63\u5728\u958b\u5c55\u3002\u6211\u5011\u5c07\u5805\u5b88’\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42’\u9019\u4e00\u4f7f\u547d\uff0c\u52a0\u5feb\u81e8\u5e8a\u958b\u767c\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002\u300d \u5728\u6b64\u6b21ASCO\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u8a72\u81e8\u5e8a\u7814\u7a76\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a Phase 1b\/2 Study of Lisaftoclax (APG-2575) Combined with Azacitidine (AZA) in Patients w ith Treatment- N a\u00efve or Prior Venetoclax- E xposed Myeloid Malignancies\u00a0 \u4e00\u9805\u8a55\u4f30 APG-2575 \uff08 Lisaftoclax \uff09\u806f\u5408\u963f\u624e\u80de\u7518\uff08 AZA \uff09\u6cbb\u7642\u521d\u6cbb\uff08 TN \uff09\u6216\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\uff08 VEN \uff09\u6cbb\u7642\u7684\u9ad3\u7cfb\u60e1\u6027\u816b\u7624\u60a3\u8005\uff08 Pts \uff09\u7684 Ib\/II \u671f\u81e8\u5e8a\u7814\u7a76 \u6458\u8981\u7de8\u865f\uff1a6505 \u5c55\u793a\u5f62\u5f0f\uff1a\u53e3\u982d\u5831\u544a \u5206\u6703\u5834\u6a19\u984c\uff1a\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u2013\u767d\u8840\u75c5\u3001\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\u53ca\u540c\u7a2e\u7570\u9ad4\u79fb\u690d\uff08Hematologic Malignancies\u2014Leukemia, Myelodysplastic Syndromes, and Allotransplant\uff09 \u4e3b\u8981\u4f5c\u8005\uff1a\u6fb3\u5927\u5229\u4e9e\u7687\u5bb6\u73c0\u65af\u91ab\u9662\uff08Royal Perth Hospital\uff09Michael Francis Leahy\uff1b\u6fb3\u5927\u5229\u4e9e\u963f\u723e\u5f17\u96f7\u5fb7\u91ab\u9662\uff08The Alfred Hospital\uff09\u3001\u6fb3\u5927\u5229\u4e9e\u8840\u6db2\u75c5\u4e2d\u5fc3\uff08Australian Centre for Blood Diseases\uff09Shaun Fleming\u535a\u58eb\uff1b\u7f8e\u570bNovant Health\u91ab\u7642\u96c6\u5718\u764c\u75c7\u7814\u7a76\u6240\uff08Novant Health Cancer Institute\uff09Patricia Kropf\u535a\u58eb\u7b49 \u6838\u5fc3\u8981\u9ede\uff1a \u7814\u7a76\u80cc\u666f\uff1a– AML\u548cMDS\u662f\u9810\u5f8c\u8f03\u5dee\u7684\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u3002– \u53bb\u7532\u57fa\u5316\u85e5\u7269\uff08HMAs\uff09AZA\u548c\u5730\u897f\u4ed6\u6ff1\u5df2\u88ab\u6279\u51c6\u7528\u65bc\u6cbb\u7642MDS\u548cAML\uff0c\u4e26\u5df2\u8b49\u660e\u53ef\u5ef6\u9577\u60a3\u8005\u7684\u751f\u5b58\u671f\u3002\u7136\u800c\uff0c\u9084\u9700\u8981\u66f4\u591a\u7684\u6cbb\u7642\u65b9\u6848\u4f86\u6539\u5584\u81e8\u5e8a\u7642\u6548\uff0c\u5982\u5b8c\u5168\u7de9\u89e3\uff08CR\uff09\u548c\u7e3d\u751f\u5b58\u671f\uff08OS\uff09\u3002– Lisaftoclax\u662f\u4e00\u7a2e\u5728\u7814\u7684\u53e3\u670d\u5c0f\u5206\u5b50Bcl-2\u6291\u5236\u5291\uff0c\u5df2\u5728\u81e8\u5e8a\u524d[1]\u548c\u81e8\u5e8a[2]\u7814\u7a76\u4e2d\u986f\u793a\u5176\u8207\u00a0AZA \u806f\u7528\u53ef\u589e\u5f37\u5c0d\u00a0AML \u548c\u00a0MDS \u7684\u6cbb\u7642\u6548\u679c\u3002\u7642\u6548\u6578\u64da\uff1a– \u622a\u81f32025\u5e744\u6708\uff0c\u572828\u4f8b\u65e2\u5f80\u7dad\u5948\u514b\u62c9\u8010\u85e5\u7684\u5fa9\u767c\/\u96e3\u6cbb AML\/\u6df7\u5408\u8868\u578b\u6025\u6027\u767d\u8840\u75c5\uff08MPAL\uff09\u60a3\u8005\u4e2d\uff0c\u7642\u6548\u53ef\u8a55\u4f30\u7684\u60a3\u8005\u670922\u4f8b\uff0c\u7e3d\u53cd\u61c9\u7387\uff08ORR\uff09\u70ba31.8%\uff087\/22\uff09\uff0c\u5176\u4e2d22.8%\u7684\u60a3\u8005CR\/ CR\u4f34\u8840\u7d30\u80de\u672a\u5b8c\u5168\u6062\u5fa9\uff08Cri\uff09\uff1b4.6% \u7684\u60a3\u8005\u7372\u90e8\u5206\u7de9\u89e3\uff08PR\uff09\uff1b4.6%\u7684\u60a3\u8005\u7372\u5f62\u614b\u5b78\u7121\u767d\u8840\u75c5\u72c0\u614b\uff08MLFS\uff09\u3002\u7372\u5f97\u6cbb\u7642\u53cd\u61c9\u7684\u60a3\u8005\u65e2\u5f80\u5747\u63a5\u53d7\u904e\u5305\u62ec\u7dad\u5948\u514b\u62c9\u5728\u5167\u7684\u591a\u7dda\u6cbb\u7642\uff0c\u4e14\u5927\u90e8\u5206\uff0871%\uff0c5\/7\uff09\u60a3\u8005\u57fa\u7dda\u5b58\u5728TP53\u7a81\u8b8a\u4e26\u4f34\u96a8\u5fa9\u96dc\u67d3\u8272\u9ad4\u6838\u578b\u3002– \u57286\u4f8b\u7642\u6548\u53ef\u8a55\u4f30\u7684\u65b0\u8a3a\u65b7\uff08ND\uff09AML\/ MPAL\u60a3\u8005\u4e2d\uff0cORR\u70ba 83.3%, \u5176\u4e2d33.3%\u7684\u60a3\u8005\u7372 CR\/CRi \uff0c50%\u7684\u60a3\u8005\u7372PR\u3002\u5728 44 \u4f8b\u7642\u6548\u53ef\u8a55\u4f30R\/R AML\/MPAL \u60a3\u8005\u4e2d\uff0cORR\u70ba 43.2%\uff0c\u5176\u4e2d31.8% \u7684\u60a3\u8005\u7372CR\/CRi \uff0c4.5%\u7684\u60a3\u8005\u7372PR\uff0c6.8% \u7684\u60a3\u8005\u7372MLFS\u3002– \u572815\u4f8b\u7642\u6548\u53ef\u8a55\u4f30\u7684 ND MDS\/\u6162\u6027\u7c92\u55ae\u6838\u7d30\u80de\u767d\u8840\u75c5\uff08CMML\uff09\u60a3\u8005\u4e2d\uff0cORR\u70ba 80%\uff0c\u5176\u4e2d40%\u7684\u60a3\u8005\u7372CR\uff0c40%\u7684\u60a3\u8005\u7372\u9aa8\u9ad3CR\uff08mCR\uff09\u300222 \u4f8b\u7642\u6548\u53ef\u8a55\u4f30\u7684 R\/R MDS\/CMML \u60a3\u8005\u4e2d\uff0cORR\u70ba 50%\uff0c\u5176\u4e2d27.3%\u7684\u60a3\u8005\u7372 CR\uff0c18.2%\u7684\u60a3\u8005\u7372 mCR\uff0c4.5%\u7684\u60a3\u8005\u7372PR\u3002 \u5b89\u5168\u6027\u6578\u64da\uff1aLisaftoclax\u806f\u5408AZA\u6cbb\u7642\uff0c\u8010\u53d7\u6027\u826f\u597d\uff0c\u5b89\u5168\u6027\u53ef\u63a7\uff0c\u5e38\u898b\u4e0d\u826f\u53cd\u61c9\u4e3b\u8981\u9ad4\u73fe\u5728\u8840\u6db2\u5b78\u4e8b\u4ef6\uff0c\u975e\u8840\u6db2\u5b78\u6bd2\u6027\u4e0d\u5e38\u898b\u3002\u7d55\u5927\u591a\u6578\u4e0d\u826f\u4e8b\u4ef6\u90fd\u53ef\u63a7\u5236\u3001\u53ef\u6062\u5fa9\u3001\u53ef\u8010\u53d7\u3002 \u7e3d\u7d50\uff1a\u00a0Lisaftoclax\u806f\u5408AZA\u6cbb\u7642TN\u6216\u5fa9\u767c\/\u96e3\u6cbb\u9ad3\u7cfb\u60e1\u6027\u816b\u7624\u60a3\u8005\uff0c\u5c55\u73fe\u51fa\u51fa\u8272\u7684\u81e8\u5e8a\u7642\u6548\u4ee5\u53ca\u5b89\u5168\u6027\u3002\u7279\u5225\u662f\uff0clisaftoclax\u5c55\u793a\u51fa\u514b\u670d\u7dad\u5948\u514b\u62c9\u8010\u85e5\u7684\u6f5b\u529b\uff0c\u662f\u570b\u969b\u4e0a\u9996\u6b21\u5831\u544a\u65b0\u578bBcl-2\u6291\u5236\u5291\u514b\u670d\u7dad\u5948\u514b\u62c9\u8010\u85e5\u7684\u81e8\u5e8a\u7814\u7a76\u3002 \u53c3\u8003\u8cc7\u6599\uff1a [1]Zhai Y, Tang Q, Fang DD, et al. Lisaftoclax in Combination with Alrizomadlin Overcomes Venetoclax Resistance in Acute Myeloid Leukemia and Acute Lymphoblastic Leukemia: Preclinical Studies. Clin Cancer Res. 2023;29:183-196. https:\/\/doi.org\/10.1158\/1078-0432.CCR-22-0978[2]Wang H, Wei X, Jiang Q, et al. Safety and Efficacy of Lisaftoclax (APG-2575), a Novel BCL-2 Inhibitor (BCL-2i), in Relapsed or Refractory (R\/R) or Treatment-Na\u00efve (TN) Patients (Pts) with Acute Myeloid leukemia (AML), Myelodysplastic Syndrome (MDS), or Other Myeloid Neoplasms. 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