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\n<\/div>\n

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\u81e8\u5e8a\u958b\u767c\u9032\u5c55<\/p>\n

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HBV\u9805\u76ee\u00a0 <\/p>\n

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\u901a\u904e\u4ee5\u4e0a\u4e09\u7a2e\u4e0d\u540c\u6cbb\u7642\u6a5f\u5236\u7684\u85e5\u7269\u7d44\u5408\u6cbb\u7642HBV\uff0c\u9a30\u76db\u535a\u85e5\u65e8\u5728\u78ba\u5b9a\u91dd\u5c0d\u4e0d\u540c\u60a3\u8005\u4e9e\u7fa4\u7684\u6700\u4f73\u6cbb\u7652\u65b9\u6848\uff0c\u53ca\u6700\u9ad8\u6548\u7684\u5be9\u8a55\u8def\u5f91\u3002\u96a8\u8457\u9a30\u76db\u535a\u85e5\u5728 HBV \u529f\u80fd\u6027\u6cbb\u7652\u65b9\u9762\u53d6\u5f97\u9032\u5c55\uff0c\u516c\u53f8\u6b63\u5728\u9032\u884c\u7684ENRICH\uff08\u8a55\u4f30BRII-179\u5728\u6fc0\u6d3bHBV\u7279\u7570\u6027\u514d\u75ab\u53ca\u7be9\u9078\u9ad8\u514d\u75ab\u61c9\u7b54\u60a3\u8005\u4e2d\u7684\u4f5c\u7528\uff09\u548cENSURE\uff08elebsiran\u806f\u5408\u805a\u4e59\u4e8c\u9187\u5e72\u64fe\u7d20\u03b1\uff08PEG-IFN\u03b1\uff09\u5c0d\u7167PEG-IFN\u03b1\u55ae\u85e5\uff09\u7814\u7a76\u9810\u8a08\u5c07\u5728 2025-2026 \u5e74\u9593\u7372\u5f97\u95dc\u9375\u6578\u64da\uff0c\u9032\u4e00\u6b65\u70ba\u5f8c\u671f\u7814\u7a76\u63d0\u4f9b\u4fe1\u606f\u3002<\/p>\n

ENHANCE\u7814\u7a76\uff1a2025\u5e741\u6708\u5b8c\u6210\u5165\u7d44\u3002\u8a722b\u671f\u96a8\u6a5f\u96d9\u76f2\u7814\u7a76\u8a55\u4f30BRII-179\u3001elebsiran\u806f\u5408PEG-IFN\u03b1\u5c0d\u6bd4PEG-IFN\u03b1\u55ae\u85e5\u5728\u975e\u809d\u786c\u5316\u6162\u6027HBV\u611f\u67d3\u60a3\u8005\uff08\u63a5\u53d7\u6838\u7518\u9178\u9006\u8f49\u9304\u9176\u6291\u5236\u5291\uff08NRTI\uff09\u80cc\u666f\u6cbb\u7642\uff09\u4e2d\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\u3002 ENSURE\u7814\u7a76\uff1a\u57282024\u5e7411\u6708\u8209\u884c\u7684\u7f8e\u570b\u809d\u75c5\u7814\u7a76\u5b78\u6703\uff08AASLD\uff09\u5e74\u6703\u4e0a\uff0c\u9a30\u76db\u535a\u85e5\u4ee5\u6700\u65b0\u7a81\u7834\u6027\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u516c\u4f48\u4e86ENSURE\u7814\u7a7648\u5468\u6cbb\u7642\u7d50\u675f\u6642\u6578\u64da\u3002\u6578\u64da\u986f\u793a\uff0celebsiran\u806f\u5408PEG-IFN\u03b1\u6cbb\u7642\u7d44\u60a3\u8005\u7684\u4e59\u809d\u8868\u9762\u6297\u539f\uff08HBsAg\uff09\u6e05\u9664\u7387\u986f\u8457\u9ad8\u65bc\u5e72\u64fe\u7d20\u55ae\u85e5\u7d44\u3002ENSURE\u7814\u7a76\u6a19\u8a8c\u8457\u696d\u5167\u9996\u6b21\u901a\u904e\u8207\u5e72\u64fe\u7d20\u55ae\u85e5\u982d\u5c0d\u982d\u7684\u6bd4\u8f03\uff0c\u660e\u78ba\u4e86siRNA\uff08elebsiran\uff09\u5728\u8207\u5e72\u64fe\u7d20\u806f\u7528\u6642\u5c0d\u529f\u80fd\u6027\u6cbb\u7652\u7684\u8ca2\u737b\uff0c\u51f8\u986f\u5176\u63d0\u5347HBV\u529f\u80fd\u6027\u6cbb\u7652\u7387\u7684\u6f5b\u529b\u3002\u9a30\u76db\u535a\u85e5\u5c07\u65bc2025\u5e74\u4e0a\u534a\u5e74\u516c\u4f48\u66f4\u591a\u95dc\u9375\u6578\u64da\u3002 ENRICH\u7814\u7a76\uff1aENSURE \u7814\u7a76\u9084\u5c0d\u66fe\u63a5\u53d7\u904e BRII-179 \u6cbb\u7642\u7684\u60a3\u8005\u9032\u884c\u4e86\u7814\u7a76\u3002\u57fa\u65bcENSURE\u7814\u7a76\u968a\u52174\u7684\u65e9\u671f\u6578\u64da\uff08\u5c07\u65bc2025\u5e74APASL\u516c\u4f48\uff09\uff0cENRICH\u7814\u7a76\u65bc2024\u5e7411\u6708\u5b8c\u6210\u5165\u7d44\uff0c\u65e8\u5728\u8a55\u4f30BRII-179\u4f5c\u70ba\u6cbb\u7652\u65b9\u6848\u4e2d\u6fc0\u6d3bHBV\u7279\u61c9\u6027\u514d\u75ab\u7684\u4e00\u90e8\u5206\uff0c\u4e26\u5c07\u5176\u4f5c\u70ba\u4e00\u7a2e\u5de5\u5177\uff0c\u7528\u65bc\u8b58\u5225\u514d\u75ab\u61c9\u7b54\u60a3\u8005\uff0c\u4ee5\u63d0\u9ad8\u529f\u80fd\u6027\u6cbb\u7652\u7684\u53ef\u80fd\u6027\u3002 \u9a30\u76db\u535a\u85e5\u7684\u958b\u767c\u5408\u4f5c\u5925\u4f34Vir Biotechnology\u57282024\u5e7411\u6708AASLD\u5e74\u6703\u4e0a\u516c\u4f48\u4e86\u51762\u671fMARCH<\/a>\u7814\u7a76\u548cSOLSTICE<\/a>\u7814\u7a76\u6578\u64da.
\nVir Biotechnology\u8fd1\u671f\u555f\u52d5\u4e863\u671f\u8a3b\u518a\u6027\u81e8\u5e8a\u8a66\u9a57ECLIPSE\u9805\u76ee\u4ee5\u5728\u8a55\u4f30tobevibart\u8207elebsiran\u806f\u5408\u7642\u6cd5\u6cbb\u7642\u6162\u6027\u4e01\u578b\u809d\u708e\uff08CHD\uff09\u3002 2024\u5e746\u6708\uff0c\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6388\u4e88Vir Biotechnology\u7528\u65bc\u6cbb\u7642CHD\u7684tobevibart\u548celebsiran \u5feb\u901f\u901a\u9053\u8a8d\u8b49\uff1b2024\u5e7411\u6708\u7372\u6b50\u6d32\u85e5\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u5b64\u5152\u85e5\u8a8d\u8b49\uff1b12\u6708\u7372FDA\u7a81\u7834\u6027\u6cbb\u7642\u54c1\u7a2e\u8a8d\u5b9a\u53caEMA\u7684PRIME\u8a8d\u8b49\uff08PRIME Designation\uff09\u3002
\n 2024\u5e745\u6708\uff0ctobevibart\u8207elebsiran\u7372\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u7a81\u7834\u6027\u6cbb\u7642\u54c1\u7a2e\u8a8d\u5b9a\u3002 <\/p>\n

\u5176\u4ed6\u81e8\u5e8a\u9805\u76ee\u00a0 <\/p>\n

\u9a30\u76db\u535a\u85e5\u6b63\u7a4d\u6975\u70baHIV\u3001\u591a\u91cd\u8010\u85e5\/\u5ee3\u6cdb\u8010\u85e5\u611f\u67d3\u53ca\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u75be\u75c5\u9818\u57df\u7684\u5019\u9078\u85e5\u7269\u5c0b\u6c42\u5916\u90e8\u5408\u4f5c\u3002\u00a0<\/p>\n

2024\u5e7410\u6708\uff0c\u9a30\u76db\u535a\u85e5\u7372\u5f97\u4e86 NMPA CDE \u7684 IND \u6279\u51c6\uff0c\u5728\u4e2d\u570b\u958b\u5c55BRII-693\uff08\u65b0\u578b\u591a\u9ecf\u83cc\u7d20\uff0c\u7528\u65bc\u6cbb\u7642\u56b4\u91cd\u9769\u862d\u6c0f\u9670\u6027\u83cc\u611f\u67d3\uff09\u76841\u671f\u85e5\u4ee3\u52d5\u529b\u5b78\u6a4b\u63a5\u8a66\u9a57\u3002\u6b64\u524d1\u671f\u6578\u64da\u5df2\u65bc2024\u5e7412\u6708\u767c\u8868\u65bc\u300aAntimicrobial Agents and Chemotherapy\u300b\u671f\u520a\uff0c\u652f\u6301\u672a\u4f86\u91dd\u5c0d\u91ab\u9662\u7372\u5f97\u6027\u7d30\u83cc\u6027\u80ba\u708e\/\u547c\u5438\u6a5f\u76f8\u95dc\u7d30\u83cc\u6027\u80ba\u708e\u7684\u5168\u74033\u671f\u8a3b\u518a\u6027\u81e8\u5e8a\u8a66\u9a57\u3002\u9a30\u76db\u535a\u85e5\u64c1\u6709BRII-693\u7684\u5168\u7403\u7368\u5bb6\u958b\u767c\u53ca\u5546\u696d\u5316\u6b0a\u76ca\u3002\u00a0 <\/p>\n

2024\u5e74\u5ea6\u4f01\u696d\u4eae\u9ede\u53ca\u8fd1\u671f\u52d5\u614b\u00a0<\/p>\n

\u80a1\u4efd\u56de\u8cfc\uff1a2024\u5e7412\u6708\uff0c\u516c\u53f8\u5ba3\u4f48\u6279\u51c66,000\u842c\u6e2f\u5143\u80a1\u7968\u56de\u8cfc\u8a08\u5283\uff08\u5360\u5df2\u767c\u884c\u80a1\u4efd10%\uff09\uff0c\u5f70\u986f\u4e86\u516c\u53f8\u5c0d\u5176\u524d\u666f\u7684\u4fe1\u5fc3\u3002\u622a\u81f32025\u5e743\u670821\u65e5\uff0c\u516c\u53f8\u5df2\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u56de\u8cfc\u7d04443.3\u842c\u80a1\uff0c\u8017\u8cc7\u7d04530\u842c\u6e2f\u5143\u3002 \u8cc7\u7522\u6536\u8cfc\uff1a2024\u5e7412\u6708\uff0c\u516c\u53f8\u8207VBI Vaccines, Inc. \u53ca\u5176\u95dc\u806f\u5b50\u516c\u53f8\u7c3d\u7f72\u4e86\u4e00\u9805\u8cc7\u7522\u8cfc\u8cb7\u5354\u8b70\uff0c\u4ee51,800<\/span>\u842c\u7f8e\u5143\u7e3d\u50f9\u6536\u8cfcBRII-179\u5b8c\u6574\u77e5\u8b58\u7522\u6b0a\u53ca\u76f8\u95dc\u8cc7\u7522\u3002\u8a72\u5354\u8b70\u53d6\u6d88\u4e86\u672a\u4f86\u5411VBI\u652f\u4ed8\u7684\u8207BRII-179\u548cPreHevbri TM\u76f8\u95dc\u7684\u8cbb\u7528\uff0c\u4e26\u89e3\u9664\u4e86\u4e4b\u524d\u65bc2024\u5e742\u670814\u65e5\u5ba3\u4f48\u7684\u5354\u8b70\u3002\u6b64\u6b21\u6536\u8cfc\u70ba\u9a30\u76db\u535a\u85e5\u5e36\u4f86\u4e86\u66f4\u591a\u7684\u5546\u696d\u7372\u76ca\uff0c\u540c\u6642\u78ba\u4fdd\u4e86 BRII-179 \u7684\u4e0d\u9593\u65b7\u81e8\u5e8a\u4f9b\u61c9\u3002\u516c\u53f8\u5c07\u7e7c\u7e8c\u958b\u767c\u9019\u4e00\u8cc7\u7522\uff0c\u76ee\u524d\u6b63\u5728\u9032\u884c\u7684\u7814\u7a76\u652f\u6301 BRII-179 \u5177\u6709\u63d0\u9ad8 HBV \u60a3\u8005\u5c0d\u6cbb\u7642\u53cd\u61c9\u7684\u6f5b\u529b\u3002 <\/p>\n

2024\u5e74\u5ea6\u8ca1\u52d9\u696d\u7e3e<\/p>\n

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\u96fb\u8a71\u6703\u8b70\u4fe1\u606f\u00a0 <\/p>\n

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