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ADC\uff0c\u5275\u52dd\u96c6\u5718\u7814\u767c\u4e8648D6\uff0c\u4e00\u7a2e\u5c08\u6709\u7684\u65b0\u578b\u4eba\u6e90\u5316\u6297LIV-1\u55ae\u6297\u3002\u8a72\u6297\u9ad4\u5177\u6709\u7368\u7279\u7684\u7d50\u5408\u8868\u4f4d\uff0c\u9ad8\u7d50\u5408\u89aa\u548c\u529b\u3001\u7279\u7570\u6027\u548c\u512a\u7570\u7684\u5167\u5316\u80fd\u529b\u3002<span>\u5b9a\u9ede<\/span>\u5076\u806f<span>\u6280\u8853<\/span>\u4ea6\u6d88\u9664\u4e86FcR\u7d50\u5408\uff0c\u5f9e\u800c\u986f\u8457\u6e1b\u5c11\u4e86\u975e\u7279\u7570\u6027FcR\u4ecb\u5c0e\u7684\u7d50\u5408\u548c\u6e05\u9664\uff0c\u4e26\u5728\u5c0f\u9f20\u4e2d\u6539\u5584\u4e86\u85e5\u4ee3\u52d5\u529b\u5b78\u7279\u6027\u3002<\/p>\n<p class=\"prntaj\">\u9ad4\u5916\u7814\u7a76\u8868\u660e\uff0c\u4e73\u817a\u816b\u7624\u7d30\u80de\uff0c\u5982MDA-MB-468\u548cMCF-7\uff0c\u5c0d\u62d3\u64b2\u7570\u69cb\u9176 I \u6291\u5236\u5291\u7684\u654f\u611f\u6027\u9ad8\u65bcMMAE\u3002\u56e0\u6b64\uff0c\u5275\u52dd\u96c6\u5718\u91c7\u7528\u7cd6\u57fa\u8f49\u79fb\u9176\u4ecb\u5c0e\u7684\u7279\u5b9a\u4f4d\u9ede\u5076\u806f\uff0c\u958b\u767c\u4e86\u5169\u6b3e\u57fa\u65bc\u62d3\u64b2\u7570\u69cb\u9176 I \u6291\u5236\u5291\u7684\u6297\u9ad4\u5076\u806f\u85e5\u7269\uff08ADC-1\u548cADC-2\uff09\u3002ADC-1\u548cADC-2\u7684\u85e5\u7269-\u6297\u9ad4\u6bd4\uff08DAR\uff09\u5747\u70ba4\uff0c\u4f46\u91c7\u7528\u4e86\u5169\u7a2e\u4e0d\u540c\u7684\u62d3\u64b2\u7570\u69cb\u9176 I \u6291\u5236\u5291\u8f09\u8377\u3002\u4f5c\u70ba\u5c0d\u7167\uff0c\u9084\u5408\u6210\u4e86\u4e00\u7a2e\u5177\u6709\u76f8\u540c\u7279\u5b9a\u4f4d\u9ede\u5076\u806f\u548c\u85e5\u7269-\u6297\u9ad4\u6bd4\u7684\uff0c\u57fa\u65bcMMAE\u7684\u6297\u9ad4\u5076\u806f\u85e5\u7269\uff08ADC-3\uff09\u3002<\/p>\n<p class=\"prntaj\">\u76e1\u7ba1 ADC-1\u548c ADC-2\u5728\u9ad4\u5916\u5c0d\u4eba\u985eLIV-1\u8868\u9054\u7684\u816b\u7624\u7d30\u80de\u5c55\u73fe\u4e86\u8207SGN-LIV1A\u985e\u4f3c\u7269\uff08DAR4\uff09\u6216ADC-3\u76f8\u4f3c\u4e14\u7279\u7570\u7684\u7d30\u80de\u6bd2\u6d3b\u6027\uff0c\u4f46\u5b83\u5011\u5728\u9ad4\u5167\u5c55\u73fe\u51fa\u9060\u9ad8\u65bcSGN-LIV1A\u985e\u4f3c\u7269\u7684\u6700\u5927\u816b\u7624\u7d30\u80de\u6bba\u50b7\u80fd\u529b\u3002\u6b64\u5916\uff0cADC-1\u548cADC-2\u5747\u5c55\u986f\u51fa\u5f37\u5927\u7684\u65c1\u89c0\u8005\u6548\u61c9\uff0c\u9019\u5c0d\u65bc\u514b\u670d\u816b\u7624\u7570\u8cea\u6027\u81f3\u95dc\u91cd\u8981\u3002<\/p>\n<p class=\"prntaj\">\u9ad4\u5167\u85e5\u7406\u7814\u7a76\u7d50\u679c\u8868\u660e\uff0cADC-1\u548cADC-2\u5728\u4eba\u985eLIV-1\u8f49\u67d3\u7684MDA-MB-468\uff08\u4e00\u7a2eTNBC\u816b\u7624\u6a21\u578b\uff09\u4e2d\u5c55\u793a\u51fa\u5291\u91cf\u4f9d\u8cf4\u4e14\u76f8\u8f03\u65bcSGN-LIV1A\u985e\u4f3c\u7269\u6216ADC-3\u66f4\u5f37\u7684\u6297\u816b\u7624\u6d3b\u6027\u3002<\/p>\n<p class=\"prntaj\">\u57283 mg\/kg\u5291\u91cf\u4e0b\uff0c\u7b2c30\u5929\u6642\uff0c\u816b\u7624\u751f\u9577\u6291\u5236\u7387 (TGI)% \u5206\u5225\u70ba\uff1aADC-1 92.4%\u3001ADC-2 94.7%\u3001ADC-3 68.5% \u3001SGN-LIV1A \u985e\u4f3c\u7269 57.0%\uff1b\u7136\u800c\uff0c\u57283 mg\/kg\u5291\u91cf\u4e0b\uff0cSGN-LIV1A\u985e\u4f3c\u7269\u6216ADC-3\u7684\u7e3d\u9ad4\u7de9\u89e3\u7387\uff08ORR\uff0c\u5373\u816b\u7624\u9ad4\u7a4d\u76f8\u8f03\u65bc\u57fa\u7dda\u6e1b\u5c1150%\uff09\u70ba0%\uff0c\u800cADC-1\u548cADC-2\u7684ORR\u5206\u5225\u70ba40%\u548c70%\u3002\u57286 mg\/kg\u5291\u91cf\u4e0b\uff0c\u7b2c42\u5929\u6642\uff0cADC-1\u548cADC-2\u7684ORR\u5206\u5225\u70ba90%\u548c100%\uff0c\u5b8c\u5168\u7de9\u89e3\u7387\uff08CR\uff09\u5206\u5225\u70ba90%\u548c100%\u3002\u57283 mg\/kg\u62166 mg\/kg\u5291\u91cf\u4e0b\uff0cADC-1\u6216ADC-2\u6c92\u6709\u986f\u8457\u5f71\u97ff\u5c0f\u9f20\u9ad4\u91cd\u3002<\/p>\n<p class=\"prntaj\">\u300cADC-1\u548cADC-2\u986f\u8457\u589e\u5f37\u7684\u6297\u816b\u7624\u6d3b\u6027\u53ef\u80fd\u6b78\u56e0\u65bc48D6\u8207 LIV-1\u7684\u9ad8\u89aa\u548c\u529b\u7d50\u5408\u4ee5\u53ca\u62d3\u64b2\u7570\u69cb\u9176 I \u6291\u5236\u5291\u5c0d\u4e73\u817a\u816b\u7624\u7d30\u80de\u7684\u9ad8\u7d30\u80de\u6bd2\u6027\u3002\u300d \u5275\u52dd\u96c6\u5718\u8463\u4e8b\u6703\u4e3b\u5e2d\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u9322\u96ea\u660e\u535a\u58eb\u8868\u793a\uff0c\u300c\u9019\u4e9b\u6578\u64da\u70ba\u6211\u5011\u9032\u4e00\u6b65\u7814\u7a76LIV-1 ADCs\uff08ADC-1 \u548c ADC-2\uff09\u63d0\u4f9b\u4e86\u4f9d\u64da\uff0c\u8a72\u6297\u9ad4\u5076\u806f\u85e5\u7269\u6709\u671b\u6210\u70baLIV-1\u967d\u6027\u4e73\u817a\u764c\u548c\u5176\u4ed6\u5be6\u9ad4\u7624\u6f5b\u5728\u7684\u4e0b\u4e00\u4ee3\u6cbb\u7642\u85e5\u7269\u3002\u300d<\/p>\n<p class=\"prntaj\">2024\u5e74\u7b2c47\u5c46\u8056\u5b89\u6771\u5c3c\u5967\u4e73\u817a\u764c\u7814\u8a0e\u6703\uff08SABCS\uff09\u65bc12\u670810\u65e5\u81f313\u65e5\u5728\u7f8e\u570b\u8056\u5b89\u6771\u5c3c\u5967\u8209\u884c\u3002SABCS\u65e8\u5728\u70ba\u570b\u969b\u5b78\u8853\u754c\u3001\u91ab\u751f\u548c\u7814\u7a76\u4eba\u54e1\u63d0\u4f9b\u4e73\u817a\u764c\u53ca\u764c\u524d\u4e73\u817a\u75be\u75c5\u7684\u5be6\u9a57\u751f\u7269\u5b78\u3001\u75c5\u56e0\u5b78\u3001\u9810\u9632\u3001\u8a3a\u65b7\u548c\u6cbb\u7642\u7684\u6700\u65b0\u76f8\u95dc\u4fe1\u606f\u3002<\/p>\n<p class=\"prntaj\">\u53c3\u8003\u6587\u737b\uff1a<\/p>\n<p class=\"prntaj\">[1] <a href=\"https:\/\/www.nature.com\/articles\/s41586-024-08031-6\" target=\"_blank\" rel=\"noopener\">https:\/\/www.nature.com\/articles\/s41586-024-08031-6<\/a>\u00a0<\/p>\n<p class=\"prntaj\">\u95dc\u65bc\u5275\u52dd\u96c6\u5718<\/p>\n<p class=\"prntaj\">\u5275\u52dd\u96c6\u5718\u662f\u4e00\u5bb6\u81e8\u5e8a\u968e\u6bb5\u7684\u5728\u751f\u7269\u85e5\u767c\u73fe\u3001\u7814\u767c\u3001\u5de5\u85dd\u958b\u767c\u548c\u751f\u7522\u65b9\u9762\u5177\u6709\u5168\u9762\u7d9c\u5408\u80fd\u529b\u7684\u751f\u7269\u5236\u85e5\u516c\u53f8\u3002<\/p>\n<p class=\"prntaj\">\u5275\u52dd\u96c6\u5718\u7e3d\u90e8\u4f4d\u65bc\u8607\u5dde\uff0c\u5df2\u6210\u529f\u642d\u5efa\u4e86\u5168\u7403\u7684\u696d\u52d9\u5e03\u5c40\uff1a\u5728\u8607\u5dde\u8a2d\u6709\u85e5\u7269\u767c\u73fe\u3001\u81e8\u5e8a\u548c\u8f49\u5316\u7814\u7a76\u4e2d\u5fc3\uff0c\u5728\u676d\u5dde\u64c1\u6709\u5de5\u85dd\u8207\u7522\u54c1\u958b\u767c\u4e2d\u5fc3\u4ee5\u53ca\u85e5\u7269\u751f\u7522\u57fa\u5730\uff0c\u5728\u7f8e\u570b\u666e\u6797\u65af\u9813\u3001\u5317\u4eac\u3001\u4e0a\u6d77\u3001\u5ee3\u5dde\u5206\u5225\u8a2d\u6709\u81e8\u5e8a\u958b\u767c\u4e2d\u5fc3\uff0c\u4e26\u5728\u7f8e\u570b\u6ce2\u58eb\u9813\u3001\u6d1b\u6749\u78ef\u8a2d\u7acb\u4e86\u696d\u52d9\u62d3\u5c55\u4e2d\u5fc3\u3002\u5275\u52dd\u96c6\u5718\u7684\u958b\u767c\u7ba1\u7dda\u5df2\u6709\u5341\u56db\u500b\u6cbb\u7642\u7528\u6297\u9ad4\u65b0\u85e5\u5206\u5b50\uff0c\u6db5\u84cb\u816b\u7624\u3001\u9aa8\u79d1\u548c\u814e\u75c5\u7b49\u9818\u57df\u3002<\/p>\n<p class=\"prntaj\">\u5982\u9700\u4e86\u89e3\u95dc\u65bc\u5275\u52dd\u96c6\u5718\u7684\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\u516c\u53f8\u7db2\u7ad9\uff1a<a href=\"https:\/\/www.transcenta.com\/\" target=\"_blank\" rel=\"noopener\">www.transcenta.com <\/a>\u6216\u9818\u82f1\u8cec\u865f\uff1aTranscenta\u3002<\/p>\n<p class=\"prntaj\">\u5a92\u9ad4\u806f\u7cfb\u4eba\uff1abryan cheng, <a href=\"mailto:bryan.cheng@transcenta.com\" target=\"_blank\" rel=\"noopener\">bryan.cheng@transcenta.com<\/a>\u00a0<\/p>\n<p class=\"prntaj\">\u00a0<\/p>","protected":false},"excerpt":{"rendered":"<p>\u7f8e\u570b\u65b0\u6fa4\u897f\u5dde\u666e\u6797\u65af\u9813\u548c\u4e2d\u570b\u8607\u5dde2024\u5e7412\u670813\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; 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LIV-1\u662f\u92c5\u8f49\u904b\u86cb\u767d\u5bb6\u65cf\u7684\u6210\u54e1\uff0c\u4e5f\u662f\u8f49\u79fb\u6027\u4e73\u817a\u764c\u4e2d\u7684\u4e00\u500b\u96cc\u6fc0\u7d20\u8abf\u63a7\u57fa\u56e0\u3002\u5728\u4e73\u817a\u764c\uff0893%\uff09\uff0c\u5305\u62ecTNBC\u548c\u6fc0\u7d20\u53d7\u9ad4\u967d\u6027\u4e73\u817a\u764c\uff0c\u4ee5\u53ca\u9ed1\u8272\u7d20\u7624\uff0882%\uff09\u3001\u524d\u5217\u817a\u764c\uff0872%\uff09\u3001\u5375\u5de2\u764c\uff0848%\uff09\u548c\u5b50\u5bae\u764c\uff0830%\uff09\u4e2d\u5747\u6709\u9ad8\u5ea6\u8868\u9054\u3002\u9019\u4f7f\u5f97LIV-1\u6210\u70ba\u4e00\u500b\u5728\u958b\u767cADC\u7642\u6cd5\u6642\u503c\u5f97\u6ce8\u610f\u7684\u7d30\u80de\u8868\u9762\u9776\u9ede\u3002 \u70ba\u4e86\u958b\u767c\u4e0b\u4e00\u4ee3LIV-1 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LIV-1\u7684\u9ad8\u89aa\u548c\u529b\u7d50\u5408\u4ee5\u53ca\u62d3\u64b2\u7570\u69cb\u9176 I \u6291\u5236\u5291\u5c0d\u4e73\u817a\u816b\u7624\u7d30\u80de\u7684\u9ad8\u7d30\u80de\u6bd2\u6027\u3002\u300d \u5275\u52dd\u96c6\u5718\u8463\u4e8b\u6703\u4e3b\u5e2d\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u9322\u96ea\u660e\u535a\u58eb\u8868\u793a\uff0c\u300c\u9019\u4e9b\u6578\u64da\u70ba\u6211\u5011\u9032\u4e00\u6b65\u7814\u7a76LIV-1 ADCs\uff08ADC-1 \u548c ADC-2\uff09\u63d0\u4f9b\u4e86\u4f9d\u64da\uff0c\u8a72\u6297\u9ad4\u5076\u806f\u85e5\u7269\u6709\u671b\u6210\u70baLIV-1\u967d\u6027\u4e73\u817a\u764c\u548c\u5176\u4ed6\u5be6\u9ad4\u7624\u6f5b\u5728\u7684\u4e0b\u4e00\u4ee3\u6cbb\u7642\u85e5\u7269\u3002\u300d 2024\u5e74\u7b2c47\u5c46\u8056\u5b89\u6771\u5c3c\u5967\u4e73\u817a\u764c\u7814\u8a0e\u6703\uff08SABCS\uff09\u65bc12\u670810\u65e5\u81f313\u65e5\u5728\u7f8e\u570b\u8056\u5b89\u6771\u5c3c\u5967\u8209\u884c\u3002SABCS\u65e8\u5728\u70ba\u570b\u969b\u5b78\u8853\u754c\u3001\u91ab\u751f\u548c\u7814\u7a76\u4eba\u54e1\u63d0\u4f9b\u4e73\u817a\u764c\u53ca\u764c\u524d\u4e73\u817a\u75be\u75c5\u7684\u5be6\u9a57\u751f\u7269\u5b78\u3001\u75c5\u56e0\u5b78\u3001\u9810\u9632\u3001\u8a3a\u65b7\u548c\u6cbb\u7642\u7684\u6700\u65b0\u76f8\u95dc\u4fe1\u606f\u3002 \u53c3\u8003\u6587\u737b\uff1a [1] https:\/\/www.nature.com\/articles\/s41586-024-08031-6\u00a0 \u95dc\u65bc\u5275\u52dd\u96c6\u5718 \u5275\u52dd\u96c6\u5718\u662f\u4e00\u5bb6\u81e8\u5e8a\u968e\u6bb5\u7684\u5728\u751f\u7269\u85e5\u767c\u73fe\u3001\u7814\u767c\u3001\u5de5\u85dd\u958b\u767c\u548c\u751f\u7522\u65b9\u9762\u5177\u6709\u5168\u9762\u7d9c\u5408\u80fd\u529b\u7684\u751f\u7269\u5236\u85e5\u516c\u53f8\u3002 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LIV-1\u7684\u9ad8\u89aa\u548c\u529b\u7d50\u5408\u4ee5\u53ca\u62d3\u64b2\u7570\u69cb\u9176 I \u6291\u5236\u5291\u5c0d\u4e73\u817a\u816b\u7624\u7d30\u80de\u7684\u9ad8\u7d30\u80de\u6bd2\u6027\u3002\u300d \u5275\u52dd\u96c6\u5718\u8463\u4e8b\u6703\u4e3b\u5e2d\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u9322\u96ea\u660e\u535a\u58eb\u8868\u793a\uff0c\u300c\u9019\u4e9b\u6578\u64da\u70ba\u6211\u5011\u9032\u4e00\u6b65\u7814\u7a76LIV-1 ADCs\uff08ADC-1 \u548c ADC-2\uff09\u63d0\u4f9b\u4e86\u4f9d\u64da\uff0c\u8a72\u6297\u9ad4\u5076\u806f\u85e5\u7269\u6709\u671b\u6210\u70baLIV-1\u967d\u6027\u4e73\u817a\u764c\u548c\u5176\u4ed6\u5be6\u9ad4\u7624\u6f5b\u5728\u7684\u4e0b\u4e00\u4ee3\u6cbb\u7642\u85e5\u7269\u3002\u300d 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