{"id":22482,"date":"2024-10-17T00:00:00","date_gmt":"2024-10-16T16:00:00","guid":{"rendered":"https:\/\/www.franchise.com.hk\/%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%8c%b9%e5%ba%b7%e5%a5%87%e6%8b%9c%e5%96%ae%e6%8a%97%ef%bc%88il-23p19%e6%8a%97%e9%ab%94%ef%bc%89%e6%b2%bb%e7%99%82%e6%bd%b0%e7%98%8d%e6%80%a7\/22482"},"modified":"2024-10-17T00:00:00","modified_gmt":"2024-10-16T16:00:00","slug":"%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%8c%b9%e5%ba%b7%e5%a5%87%e6%8b%9c%e5%96%ae%e6%8a%97%ef%bc%88il-23p19%e6%8a%97%e9%ab%94%ef%bc%89%e6%b2%bb%e7%99%82%e6%bd%b0%e7%98%8d%e6%80%a7","status":"publish","type":"post","link":"https:\/\/www.franchise.com.hk\/en\/%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%8c%b9%e5%ba%b7%e5%a5%87%e6%8b%9c%e5%96%ae%e6%8a%97%ef%bc%88il-23p19%e6%8a%97%e9%ab%94%ef%bc%89%e6%b2%bb%e7%99%82%e6%bd%b0%e7%98%8d%e6%80%a7\/22482","title":{"rendered":"\u4fe1\u9054\u751f\u7269\u5ba3\u5e03\u5339\u5eb7\u5947\u62dc\u55ae\u6297\uff08IL-23p19\u6297\u9ad4\uff09\u6cbb\u7642\u6f70\u760d\u6027\u7d50\u8178\u708e\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\u9054\u6210\u4e3b\u8981\u7d42\u9ede"},"content":{"rendered":"

\u7f8e\u570b\u820a\u91d1\u5c71\u548c\u4e2d\u570b\u8607\u5dde<\/span>2024\u5e7410\u670817\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u4fe1\u9054\u751f\u7269\u5236\u85e5\u96c6\u5718\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u80a1\u7968\u4ee3\u78bc\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u53ca\u5fc3\u8840\u7ba1\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u5275\u65b0\u85e5\u7269\u7684\u751f\u7269\u5236\u85e5\u516c\u53f8\u5ba3\u5e03\uff1a\u5339\u5eb7\u5947\u62dc\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u91cd\u7d44\u6297\u767d\u4ecb\u7d2023p19\u4e9e\u57fa\uff08IL-23p19\uff09\u6297\u9ad4\uff0c\u7814\u767c\u4ee3\u865f\uff1aIBI112\uff09\u5728\u4e2d\u570b\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\uff08UC\uff09\u53d7\u8a66\u8005\u4e2d\u958b\u5c55\u7684\u4e00\u9805\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\uff08Clinicaltrials.gov, NCT05377580\uff09\u4e2d\u9054\u6210\u4e3b\u8981\u7d42\u9ede\u3002<\/p>\n

\u8a72\u7814\u7a76\u65e8\u5728\u8a55\u50f9\u5339\u5eb7\u5947\u62dc\u55ae\u6297\u8a98\u5c0e\u6cbb\u7642\u548c\u7dad\u6301\u6cbb\u7642\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\uff08\u5165\u9078\u6a19\u51c6\u70ba\u6539\u826fMayo\u8a55\u52064\uff5e9\u5206\uff0c\u4e14\u5176\u4e2d\u5167\u93e1\u8a55\u5206\u22652\u5206\uff09\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u7814\u7a76\u5171\u5165\u7d44150\u4f8b\u53d7\u8a66\u8005\uff0c\u63091:1:1\u7684\u6bd4\u4f8b\u96a8\u6a5f\u63a5\u53d7\u5b89\u6170\u5291\u3001\u5339\u5eb7\u5947\u62dc\u55ae\u6297200 mg\u6216\u5339\u5eb7\u5947\u62dc\u55ae\u6297600 mg\u7b2c0\u30014\u30018\u5468\u975c\u8108\u8f38\u6ce8\u6cbb\u7642\uff0c\u8a98\u5c0e\u6cbb\u7642\u5f8c\u91c7\u7528200 mg\u5339\u5eb7\u5947\u62dc\u55ae\u6297\u6bcf4\u5468\u6216\u6bcf8\u5468\u76ae\u4e0b\u6ce8\u5c04\u9032\u884c\u7dad\u6301\u6cbb\u7642\u3002\u7814\u7a76\u4e3b\u8981\u7d42\u9ede\u70ba\u8a98\u5c0e\u6cbb\u7642\u671f\u7b2c12\u5468\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\uff08\u5b9a\u7fa9\u70ba\u6539\u826fMayo\u8a55\u5206\u7684\u4fbf\u8840\u70ba0\u5206\uff0c\u6392\u4fbf\u6b21\u6578\u22641\u5206\u4ee5\u53ca\u5167\u93e1\u767c\u73fe\u22641\u5206\uff09\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u3002\u6b21\u8981\u7d42\u9ede\u5305\u62ec\u8a98\u5c0e\u6cbb\u7642\u671f\u7b2c12\u5468\u9054\u5230\u81e8\u5e8a\u61c9\u7b54\u3001\u75c7\u72c0\u7de9\u89e3\u3001\u5167\u93e1\u7de9\u89e3\u6216\u9ecf\u819c\u6108\u5408\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u7b49\u3002<\/p>\n

\u7814\u7a76\u9054\u6210\u4e3b\u8981\u7d42\u9ede\u548c\u6b21\u8981\u7d42\u9ede\uff0c\u5373\uff1a<\/p>\n

\u8a98\u5c0e\u6cbb\u7642\u671f\u7b2c12\u5468\u6642\uff0c\u5339\u5eb7\u5947\u62dc\u55ae\u6297200 mg\u7d44\u548c600 mg\u7d44\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u5206\u5225\u662f20.0%\u548c14.0%\uff0c\u5747\u986f\u8457\u9ad8\u65bc\u5b89\u6170\u5291\u7d44\uff082.0%\uff1bp <0.05\uff09\u3002 \u5339\u5eb7\u5947\u62dc\u55ae\u6297200 mg\u7d44\u548c600 mg\u7d44\u9054\u5230\u81e8\u5e8a\u61c9\u7b54\u7684\u53d7\u8a66\u8005\u5206\u5225\u70ba54.0%\u548c68.0%\uff0c\u5747\u986f\u8457\u9ad8\u65bc\u5b89\u6170\u5291\u7d44\uff0822.0%\uff1bp <0.001\uff09\u3002 \u6b64\u5916\uff0c\u5339\u5eb7\u5947\u62dc\u55ae\u6297200 mg\u7d44\u548c600 mg\u7d44\u9054\u5230\u75c7\u72c0\u7de9\u89e3\u3001\u5167\u93e1\u7de9\u89e3\u6216\u9ecf\u819c\u6108\u5408\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u5747\u9ad8\u65bc\u5b89\u6170\u5291\u7d44\u3002 <\/p>\n

\u5b89\u5168\u6027\u65b9\u9762\uff0c\u5339\u5eb7\u5947\u62dc\u55ae\u6297\u7d44\u7e3d\u9ad4\u5b89\u5168\u6027\u826f\u597d\uff0c\u672a\u767c\u73fe\u65b0\u589e\u5b89\u5168\u6027\u4fe1\u865f\uff0c\u8207\u65e2\u5f80\u7814\u7a76\u548c\u540c\u985e\u7522\u54c1\u7684\u5b89\u5168\u6027\u7279\u5f81\u76f8\u4f3c\u3002<\/p>\n

\u622a\u81f3\u76ee\u524d\u7814\u7a76\u7dad\u6301\u671f\u4ecd\u5728\u9032\u884c\u4e2d\uff0c\u9032\u5165\u7dad\u6301\u671f\u7684\u53d7\u8a66\u8005\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\u3001\u81e8\u5e8a\u61c9\u7b54\u3001\u75c7\u72c0\u7de9\u89e3\u3001\u5167\u93e1\u7de9\u89e3\u6216\u9ecf\u819c\u6108\u5408\u7684\u6bd4\u4f8b\u76f8\u8f03\u8a98\u5c0e\u671f\u5747\u6709\u4e0d\u540c\u7a0b\u5ea6\u7684\u7e7c\u7e8c\u63d0\u5347\u3002\u5b8c\u6574\u6578\u64da\u8a08\u5283\u5728\u672a\u4f86\u5b78\u8853\u5927\u6703\u6216\u671f\u520a\u6295\u7a3f\u767c\u8868\u3002<\/p>\n

\u8a72\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u4e2d\u5c71\u5927\u5b78\u9644\u5c6c\u7b2c\u4e00\u91ab\u9662\u9673\u65fb\u6e56\u6559\u6388\u8868\u793a\uff1a\u300c\u6f70\u760d\u6027\u7d50\u8178\u708e\u662f\u4e00\u7a2e\u6162\u6027\u3001\u5fa9\u767c\u6027\u7684\u7d50\u76f4\u8178\u9ecf\u819c\u708e\u75c7\u75be\u75c5\uff0c\u8207\u907a\u50b3\u3001\u74b0\u5883\u548c\u514d\u75ab\u7cfb\u7d71\u56e0\u7d20\u76f8\u4e92\u4f5c\u7528\u6709\u95dc\u3002\u5e38\u898b\u75c7\u72c0\u5305\u62ec\u8179\u75db\u3001\u8179\u7009\u3001\u4fbf\u8840\u3001\u9ad4\u91cd\u6e1b\u8f15\u548c\u75b2\u52de\u7b49\u3002\u73fe\u6709\u6cbb\u7642\u624b\u6bb5\u4e3b\u8981\u96c6\u4e2d\u5728\u63a7\u5236\u708e\u75c7\u3001\u7de9\u89e3\u75c7\u72c0\u548c\u7dad\u6301\u7de9\u89e3\u3002\u76e1\u7ba1\u6cbb\u7642\u65b9\u6cd5\u4e0d\u65b7\u9032\u6b65\uff0c\u4f46\u4ecd\u9762\u81e8\u8af8\u591a\u6311\u6230\uff0c\u4e9f\u5f85\u65b0\u7684\u6cbb\u7642\u624b\u6bb5\u3002\u6211\u5f88\u9ad8\u8208\u770b\u5230\u5339\u5eb7\u5947\u62dc\u55ae\u6297\u6cbb\u7642\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178II\u671f\u81e8\u5e8a\u7814\u7a76\u4e2d\u9054\u6210\u4e3b\u8981\u7d42\u9ede\uff0c\u53d7\u8a66\u8005\u7372\u5f97\u986f\u8457\u7684\u8a98\u5c0e\u671f\u81e8\u5e8a\u7372\u76ca\uff0c\u540c\u6642\u5b89\u5168\u6027\u826f\u597d\u3002\u6211\u671f\u5f85\u672a\u4f86\u7522\u54c1\u9806\u5229\u958b\u767c\uff0c\u70ba\u4e2d\u570b\u6f70\u760d\u6027\u7d50\u8178\u708e\u60a3\u8005\u63d0\u4f9b\u66f4\u591a\u7684\u6cbb\u7642\u9078\u64c7\u3002\u300d<\/p>\n

\u4fe1\u9054\u751f\u7269\u5236\u85e5\u96c6\u5718\u81e8\u5e8a\u9ad8\u7d1a\u526f\u7e3d\u88c1\u9322\u9433\u535a\u58eb\u8868\u793a\uff1a\u300c\u6f70\u760d\u6027\u7d50\u8178\u708e\u4f5c\u70ba\u4e00\u7a2e\u6162\u6027\u708e\u75c7\u6027\u75be\u75c5\uff0c\u9664\u537b\u5c0d\u8eab\u9ad4\u5065\u5eb7\u7684\u640d\u5bb3\uff0c\u5176\u5c0d\u60a3\u8005\u7684\u65e5\u5e38\u751f\u6d3b\u4e5f\u6709\u56b4\u91cd\u5e72\u64fe\uff0c\u5c0d\u60a3\u8005\u7684\u5fc3\u7406\u7522\u751f\u5de8\u5927\u7684\u8ca0\u9762\u5f71\u97ff\u3002\u8fd1\u5e74\u4f86\uff0c\u4ee5IL-23\u70ba\u9776\u9ede\u7684\u65b0\u4e00\u4ee3\u85e5\u7269\u56e0\u5176\u5728\u6f70\u760d\u6027\u7d50\u8178\u708e\u60a3\u8005\u6cbb\u7642\u4e2d\u5353\u8d8a\u7684\u7642\u6548\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u5f15\u767c\u95dc\u6ce8\uff1b\u76ee\u524d\uff0c\u570b\u5167\u5e02\u5834\u4e0a\u5c1a\u7121IL-23p19\u9776\u9ede\u85e5\u7269\u7372\u6279\u6cbb\u7642\u6f70\u760d\u6027\u7d50\u8178\u708e\uff0c\u672c\u7814\u7a76\u662f\u7b2c\u4e00\u500b\u7531\u570b\u5167\u4f01\u696d\u81ea\u4e3b\u7814\u767c\u7684IL-23p19\u55ae\u6297\u6cbb\u7642\u6f70\u760d\u6027\u7d50\u8178\u708e\u7684\u81e8\u5e8a\u7814\u7a76\u3002\u4fe1\u9054\u751f\u7269\u81ea\u4e3b\u7814\u767c\u7684\u5339\u5eb7\u5947\u62dc\u55ae\u6297\u5df2\u7d93\u5728\u6591\u584a\u72c0\u9280\u5c51\u75c5\u53d6\u5f97\u6210\u529f\uff0c\u672c\u6b21\u5728\u6f70\u760d\u6027\u7d50\u8178\u708eII\u671f\u81e8\u5e8a\u7814\u7a76\u4e2d\u7684\u7d50\u679c\u512a\u7570\uff0c\u8a98\u5c0e\u671f\u7642\u6548\u3001\u7dad\u6301\u671f\u7684\u521d\u6b65\u7642\u6548\u53ca\u5176\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u4f7f\u6211\u5011\u66f4\u6df1\u53d7\u9f13\u821e\uff0c\u6211\u5011\u671f\u5f85\u4fe1\u9054\u751f\u7269\u66f4\u591a\u53ef\u53ca\u6027\u826f\u597d\u4e14\u9ad8\u8cea\u91cf\u7684\u5275\u65b0\u751f\u7269\u85e5\u53ef\u4ee5\u65e9\u65e5\u60e0\u53ca\u5ee3\u5927\u60a3\u8005\u3002\u300d<\/p>\n

\u95dc\u65bc\u6f70\u760d\u6027\u7d50\u8178\u708e<\/p>\n

\u6f70\u760d\u6027\u7d50\u8178\u708e\u70ba\u4e00\u7a2e\u6162\u6027\u975e\u7279\u7570\u6027\u8178\u9053\u708e\u75c7\u6027\u75be\u75c5\uff08IBD\uff09\uff0c\u4ee5\u7d50\u8178\u548c\u76f4\u8178\u708e\u75c7\u70ba\u7279\u5f81\u3002\u5178\u578b\u75c7\u72c0\u70ba\u53cd\u5fa9\u767c\u4f5c\u7684\u8179\u7009\u3001\u7c98\u6db2\u81bf\u8840\u4fbf\u4f34\u8179\u75db\u3001\u88e1\u6025\u5f8c\u91cd\u3002\u6f70\u760d\u6027\u7d50\u8178\u708e\u56b4\u91cd\u5a01\u8105\u8eab\u9ad4\u5065\u5eb7\u4e26\u5c0d\u65e5\u5e38\u751f\u6d3b\u548c\u5fc3\u7406\u5e36\u4f86\u5f71\u97ff\u3002\u6f70\u760d\u6027\u7d50\u8178\u708e\u597d\u767c\u65bc\u4e2d\u9752\u5e74\uff0c\u5728\u4e2d\u570b\uff0c\u8fd120\u5e74\u4f86\u5c31\u8a3a\u4eba\u6578\u5448\u5feb\u901f\u4e0a\u5347\u8da8\u52e2\uff0c\u60a3\u75c5\u7387\u70ba11.6\/10\u842c\u3002\u6f70\u760d\u6027\u7d50\u8178\u708e\u7684\u81e8\u5e8a\u6cbb\u7642\u624b\u6bb5\u4ee5\u85e5\u7269\u548c\u624b\u8853\u6cbb\u7642\u70ba\u4e3b\uff0c\u786b\u560c\u5464\u85e5\u7269\u70ba\u6700\u50b3\u7d71\u7684\u6cbb\u7642\u514d\u75ab\u6291\u5236\u5291\uff0c\u4f46\u4e0d\u826f\u53cd\u61c9\u767c\u751f\u7387\u9ad8\u3002\u751f\u7269\u5236\u5291\u65b9\u9762\uff0c\u6297TNF-\u03b1\u6cbb\u7642\u5b58\u5728\u85e5\u7269\u514d\u75ab\u539f\u6027\u5c0e\u81f4\u7684\u5931\u53bb\u61c9\u7b54\u554f\u984c\u3002\u8fd1\u5e74\u4f86\u91dd\u5c0dIL-12\u3001IL-23\u7b49\u9776\u9ede\u7684\u85e5\u7269\u5728\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u4e0a\u5c55\u73fe\u4e86\u512a\u52e2\uff0c\u4f46\u76ee\u524d\u6211\u570b\u4ecd\u6c92\u6709IL-23p19\u9776\u9ede\u85e5\u7269\u7372\u6279\u7528\u65bc\u6cbb\u7642\u6f70\u760d\u6027\u7d50\u8178\u708e\uff0c\u81e8\u5e8a\u4e0a\u4ecd\u5b58\u5728\u5de8\u5927\u7684\u9700\u6c42\u3002<\/p>\n

\u95dc\u65bc\u5339\u5eb7\u5947\u62dc\u55ae\u6297\uff08IBI112\uff09<\/p>\n

\u5339\u5eb7\u5947\u62dc\u55ae\u6297\uff08IBI112\uff09\u70ba\u91cd\u7d44\u6297\u767d\u4ecb\u7d2023p19\u4e9e\u57fa\uff08IL-23p19\uff09\u6297\u9ad4\u6ce8\u5c04\u6db2\uff0c\u662f\u7531\u4fe1\u9054\u751f\u7269\u81ea\u4e3b\u7814\u767c\uff0c\u5177\u6709\u81ea\u4e3b\u77e5\u8b58\u7522\u6b0a\u7684\u4e00\u7a2e\u55ae\u514b\u9686\u6297\u9ad4\uff0c\u7279\u7570\u6027\u7d50\u5408IL-23p19\u4e9e\u57fa\u3002\u901a\u904e\u963b\u6b62IL-23\u8207\u7d30\u80de\u8868\u9762\u53d7\u9ad4\u7d50\u5408\uff0c\u963b\u65b7IL-23\u53d7\u9ad4\u4ecb\u5c0e\u4fe1\u865f\u901a\u8def\u767c\u63ee\u6297\u708e\u4f5c\u7528\u3002IBI112\u6709\u671b\u70ba\u9280\u5c51\u75c5\u3001\u6f70\u760d\u6027\u8178\u708e\u548c\u5176\u4ed6\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u60a3\u8005\u63d0\u4f9b\u66f4\u6709\u6548\u3001\u66f4\u9577\u7d66\u85e5\u5468\u671f\u7684\u6cbb\u7642\u65b9\u6848\u3002<\/p>\n

\u5339\u5eb7\u5947\u62dc\u55ae\u6297\u7576\u524d\u958b\u5c55\u4e86\u591a\u9805\u81e8\u5e8a\u7814\u7a76\uff0c\u5305\u62ec\uff1a<\/p>\n

\u5728\u4e2d\u91cd\u5ea6\u9280\u5c51\u75c5\u60a3\u8005\u4e2d\u958b\u5c55\u7684\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff08CLEAR-1\uff09\uff0c\u5df2\u65bc2024\u5e745\u6708\u9054\u6210\u7d42\u9ede\uff1b \u5728\u4e2d\u91cd\u5ea6\u9280\u5c51\u75c5\u60a3\u8005\u4e2d\u958b\u5c55\u7684\u96a8\u6a5f\u64a4\u85e5\u518d\u6cbb\u7642\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff1b \u5728\u4e2d\u91cd\u5ea6\u9280\u5c51\u75c5\u60a3\u8005\u4e2d\u958b\u5c55\u7684\u751f\u7269\u5236\u5291\u6cbb\u7642\u8f49\u5339\u5eb7\u5947\u62dc\u55ae\u6297\u6cbb\u7642\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\uff1b \u5728\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\u60a3\u8005\u4e2d\u958b\u5c55\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\u3002 <\/p>\n

2024\u5e749\u6708\uff0c\u5339\u5eb7\u5947\u62dc\u55ae\u6297\u7684\u9996\u500bNDA\u7372NMPA\u53d7\u7406\uff0c\u7528\u65bc\u6cbb\u7642\u4e2d\u91cd\u5ea6\u6591\u584a\u72c0\u9280\u5c51\u75c5\u3002<\/p>\n

\u95dc\u65bc\u4fe1\u9054\u751f\u7269<\/p>\n

\u300c\u59cb\u65bc\u4fe1\uff0c\u9054\u65bc\u884c\u300d\uff0c\u958b\u767c\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8cea\u91cf\u751f\u7269\u85e5\uff0c\u662f\u4fe1\u9054\u751f\u7269\u7684\u4f7f\u547d\u548c\u76ee\u6a19\u3002\u4fe1\u9054\u751f\u7269\u6210\u7acb\u65bc2011\u5e74\uff0c\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u7684\u5275\u65b0\u85e5\u7269\uff0c\u8b93\u6211\u5011\u7684\u5de5\u4f5c\u60e0\u53ca\u66f4\u591a\u7684\u751f\u547d\u3002\u516c\u53f8\u5df2\u670911\u500b\u7522\u54c1\u7372\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c\u5b83\u5011\u5206\u5225\u662f\u4fe1\u8fea\u5229\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u4f2f\u8212\u00ae\uff09\uff0c\u8c9d\u4f10\u73e0\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u6538\u540c\u00ae\uff09\uff0c\u963f\u9054\u6728\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u8607\u7acb\u4fe1\u00ae\uff09\uff0c\u5229\u59a5\u6614\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u4f2f\u83ef\u00ae\uff09\uff0c\u4f69\u7c73\u66ff\u5c3c\u7247\uff08\u9054\u4f2f\u5766\u00ae\uff09\uff0c\u5967\u96f7\u5df4\u66ff\u5c3c\u7247\uff08\u8010\u7acb\u514b\u00ae\uff09\uff0c\u96f7\u83ab\u897f\u5c24\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u5e0c\u5189\u64c7\u00ae\uff09\uff0c\u585e\u666e\u66ff\u5c3c\u81a0\u56ca\uff08\u777f\u59a5\u00ae\uff09\uff0c\u4f0a\u57fa\u5967\u4f96\u8cfd\u6ce8\u5c04\u6db2\uff08\u798f\u53ef\u8607\u00ae\uff09\uff0c\u6258\u840a\u897f\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u4fe1\u5fc5\u6a02\u00ae\uff09\u548c\u6c1f\u6fa4\u96f7\u585e\u7247\uff08\u9054\u4f2f\u7279\u00ae\uff09\u3002\u76ee\u524d\uff0c\u540c\u6642\u9084\u67095\u500b\u54c1\u7a2e\u5728NMPA\u5be9\u8a55\u4e2d\uff0c3\u500b\u65b0\u85e5\u5206\u5b50\u9032\u5165III\u671f\u6216\u95dc\u9375\u6027\u81e8\u5e8a\u7814\u7a76\uff0c\u53e6\u5916\u9084\u670917\u500b\u65b0\u85e5\u54c1\u7a2e\u5df2\u9032\u5165\u81e8\u5e8a\u7814\u7a76\u3002<\/p>\n

\u516c\u53f8\u5df2\u8207\u79ae\u4f86\u3001\u7f85\u6c0f\u3001\u8cfd\u8afe\u83f2\u3001Adimab\u3001Incyte\u548cMD Anderson \u764c\u75c7\u4e2d\u5fc3\u7b49\u570b\u969b\u5408\u4f5c\u65b9\u9054\u621030\u591a\u9805\u6230\u7565\u5408\u4f5c\u3002\u4fe1\u9054\u751f\u7269\u5728\u4e0d\u65b7\u81ea\u7814\u5275\u65b0\u85e5\u7269\u3001\u8b00\u6c42\u81ea\u8eab\u767c\u5c55\u7684\u540c\u6642\uff0c\u79c9\u627f\u7d93\u6fdf\u5efa\u8a2d\u4ee5\u4eba\u6c11\u70ba\u4e2d\u5fc3\u7684\u767c\u5c55\u601d\u60f3\u3002\u591a\u5e74\u4f86\uff0c\u59cb\u7d42\u5fc3\u61f7\u79d1\u5b78\u5584\u5ff5\uff0c\u5805\u5b88\u300c\u4ee5\u60a3\u8005\u70ba\u4e2d\u5fc3\u300d\uff0c\u5fc3\u7cfb\u60a3\u8005\u4e26\u95dc\u6ce8\u60a3\u8005\u5bb6\u5ead\uff0c\u7a4d\u6975\u5c65\u884c\u793e\u6703\u8cac\u4efb\u3002\u516c\u53f8\u9678\u7e8c\u767c\u8d77\u3001\u53c3\u8207\u4e86\u591a\u9805\u85e5\u54c1\u516c\u76ca\u63f4\u52a9\u9805\u76ee\uff0c\u8b93\u8d8a\u4f86\u8d8a\u591a\u7684\u60a3\u8005\u80fd\u5920\u5f97\u76ca\u65bc\u751f\u547d\u79d1\u5b78\u7684\u9032\u6b65\uff0c\u8cb7\u5f97\u5230\u3001\u7528\u5f97\u8d77\u9ad8\u8cea\u91cf\u7684\u751f\u7269\u85e5\u3002\u622a\u81f3\u76ee\u524d\uff0c\u4fe1\u9054\u751f\u7269\u60a3\u8005\u63f4\u52a9\u9805\u76ee\u5df2\u60e0\u53ca17\u4f59\u842c\u666e\u901a\u60a3\u8005\uff0c\u85e5\u7269\u6350\u8d08\u7e3d\u50f9\u503c34\u5104\u5143\u4eba\u6c11\u5e63\u3002\u4fe1\u9054\u751f\u7269\u5e0c\u671b\u548c\u5927\u5bb6\u4e00\u8d77\u52aa\u529b\uff0c\u63d0\u9ad8\u4e2d\u570b\u751f\u7269\u5236\u85e5\u7522\u696d\u7684\u767c\u5c55\u6c34\u5e73\uff0c\u4ee5\u6eff\u8db3\u767e\u59d3\u7528\u85e5\u53ef\u53ca\u6027\u548c\u4eba\u6c11\u5c0d\u751f\u547d\u5065\u5eb7\u7f8e\u597d\u9858\u671b\u7684\u8ffd\u6c42\u3002<\/p>\n

\u8a73\u60c5\u8acb\u8a2a\u554f\u516c\u53f8\u7db2\u7ad9\uff1awww.innoventbio.com\u6216\u516c\u53f8\u9818\u82f1\u8cec\u865f\u3002<\/p>\n

\u8072\u660e\uff1a\u4fe1\u9054\u4e0d\u63a8\u85a6\u4efb\u4f55\u672a\u7372\u6279\u7684\u85e5\u54c1\/\u9069\u61c9\u75c7\u4f7f\u7528\u3002<\/p>\n

\u524d\u77bb\u6027\u8072\u660e<\/p>\n

\u672c\u65b0\u805e\u7a3f\u6240\u767c\u5e03\u7684\u4fe1\u606f\u4e2d\u53ef\u80fd\u6703\u5305\u542b\u67d0\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u3002\u9019\u4e9b\u8868\u8ff0\u672c\u8cea\u4e0a\u5177\u6709\u76f8\u7576\u98a8\u96aa\u548c\u4e0d\u78ba\u5b9a\u6027\u3002\u5728\u4f7f\u7528\u300c\u9810\u671f\u300d\u3001\u300c\u76f8\u4fe1\u300d\u3001\u300c\u9810\u6e2c\u300d\u3001\u300c\u671f\u671b\u300d\u3001\u300c\u6253\u7b97\u300d\u53ca\u5176\u4ed6\u985e\u4f3c\u8a5e\u8a9e\u9032\u884c\u8868\u8ff0\u6642\uff0c\u51e1\u8207\u672c\u516c\u53f8\u6709\u95dc\u7684\uff0c\u76ee\u7684\u5747\u662f\u8981\u6307\u660e\u5176\u5c6c\u524d\u77bb\u6027\u8868\u8ff0\u3002\u672c\u516c\u53f8\u4e26\u7121\u7fa9\u52d9\u4e0d\u65b7\u5730\u66f4\u65b0\u9019\u4e9b\u9810\u6e2c\u6027\u9673\u8ff0\u3002<\/p>\n

\u9019\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u4e43\u57fa\u65bc\u672c\u516c\u53f8\u7ba1\u7406\u5c64\u5728\u505a\u51fa\u8868\u8ff0\u6642\u5c0d\u672a\u4f86\u4e8b\u52d9\u7684\u73fe\u6709\u770b\u6cd5\u3001\u5047\u8a2d\u3001\u671f\u671b\u3001\u4f30\u8a08\u3001\u9810\u6e2c\u548c\u7406\u89e3\u3002\u9019\u4e9b\u8868\u8ff0\u4e26\u975e\u5c0d\u672a\u4f86\u767c\u5c55\u7684\u4fdd\u8b49\uff0c\u6703\u53d7\u5230\u98a8\u96aa\u3001\u4e0d\u78ba\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u97ff\uff0c\u6709\u4e9b\u4e43\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u8303\u570d\uff0c\u96e3\u4ee5\u9810\u8a08\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u5011\u7684\u696d\u52d9\u3001\u7af6\u722d\u74b0\u5883\u3001\u653f\u6cbb\u3001\u7d93\u6fdf\u3001\u6cd5\u5f8b\u548c\u793e\u6703\u60c5\u6cc1\u7684\u672a\u4f86\u8b8a\u5316\u53ca\u767c\u5c55\u7684\u5f71\u97ff\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u6703\u8207\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8cc7\u6599\u6709\u8f03\u5927\u5dee\u5225\u3002<\/p>","protected":false},"excerpt":{"rendered":"

\u7f8e\u570b\u820a\u91d1\u5c71\u548c\u4e2d\u570b\u8607\u5dde2024\u5e7410\u670817\u65e5 \/\u7f8e\u901a\u793e\/ — \u4fe1\u9054\u751f\u7269\u5236\u85e5\u96c6\u5718\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u80a1\u7968\u4ee3\u78bc\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u53ca\u5fc3\u8840\u7ba1\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u5275\u65b0\u85e5\u7269\u7684\u751f\u7269\u5236\u85e5\u516c\u53f8\u5ba3\u5e03\uff1a\u5339\u5eb7\u5947\u62dc\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u91cd\u7d44\u6297\u767d\u4ecb\u7d2023p19\u4e9e\u57fa\uff08IL-23p19\uff09\u6297\u9ad4\uff0c\u7814\u767c\u4ee3\u865f\uff1aIBI112\uff09\u5728\u4e2d\u570b\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\uff08UC\uff09\u53d7\u8a66\u8005\u4e2d\u958b\u5c55\u7684\u4e00\u9805\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\uff08Clinicaltrials.gov, NCT05377580\uff09\u4e2d\u9054\u6210\u4e3b\u8981\u7d42\u9ede\u3002 \u8a72\u7814\u7a76\u65e8\u5728\u8a55\u50f9\u5339\u5eb7\u5947\u62dc\u55ae\u6297\u8a98\u5c0e\u6cbb\u7642\u548c\u7dad\u6301\u6cbb\u7642\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\uff08\u5165\u9078\u6a19\u51c6\u70ba\u6539\u826fMayo\u8a55\u52064\uff5e9\u5206\uff0c\u4e14\u5176\u4e2d\u5167\u93e1\u8a55\u5206\u22652\u5206\uff09\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u7814\u7a76\u5171\u5165\u7d44150\u4f8b\u53d7\u8a66\u8005\uff0c\u63091:1:1\u7684\u6bd4\u4f8b\u96a8\u6a5f\u63a5\u53d7\u5b89\u6170\u5291\u3001\u5339\u5eb7\u5947\u62dc\u55ae\u6297200 mg\u6216\u5339\u5eb7\u5947\u62dc\u55ae\u6297600 mg\u7b2c0\u30014\u30018\u5468\u975c\u8108\u8f38\u6ce8\u6cbb\u7642\uff0c\u8a98\u5c0e\u6cbb\u7642\u5f8c\u91c7\u7528200 mg\u5339\u5eb7\u5947\u62dc\u55ae\u6297\u6bcf4\u5468\u6216\u6bcf8\u5468\u76ae\u4e0b\u6ce8\u5c04\u9032\u884c\u7dad\u6301\u6cbb\u7642\u3002\u7814\u7a76\u4e3b\u8981\u7d42\u9ede\u70ba\u8a98\u5c0e\u6cbb\u7642\u671f\u7b2c12\u5468\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\uff08\u5b9a\u7fa9\u70ba\u6539\u826fMayo\u8a55\u5206\u7684\u4fbf\u8840\u70ba0\u5206\uff0c\u6392\u4fbf\u6b21\u6578\u22641\u5206\u4ee5\u53ca\u5167\u93e1\u767c\u73fe\u22641\u5206\uff09\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u3002\u6b21\u8981\u7d42\u9ede\u5305\u62ec\u8a98\u5c0e\u6cbb\u7642\u671f\u7b2c12\u5468\u9054\u5230\u81e8\u5e8a\u61c9\u7b54\u3001\u75c7\u72c0\u7de9\u89e3\u3001\u5167\u93e1\u7de9\u89e3\u6216\u9ecf\u819c\u6108\u5408\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u7b49\u3002 \u7814\u7a76\u9054\u6210\u4e3b\u8981\u7d42\u9ede\u548c\u6b21\u8981\u7d42\u9ede\uff0c\u5373\uff1a \u8a98\u5c0e\u6cbb\u7642\u671f\u7b2c12\u5468\u6642\uff0c\u5339\u5eb7\u5947\u62dc\u55ae\u6297200 mg\u7d44\u548c600 mg\u7d44\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u5206\u5225\u662f20.0%\u548c14.0%\uff0c\u5747\u986f\u8457\u9ad8\u65bc\u5b89\u6170\u5291\u7d44\uff082.0%\uff1bp <0.05\uff09\u3002 \u5339\u5eb7\u5947\u62dc\u55ae\u6297200 mg\u7d44\u548c600 mg\u7d44\u9054\u5230\u81e8\u5e8a\u61c9\u7b54\u7684\u53d7\u8a66\u8005\u5206\u5225\u70ba54.0%\u548c68.0%\uff0c\u5747\u986f\u8457\u9ad8\u65bc\u5b89\u6170\u5291\u7d44\uff0822.0%\uff1bp <0.001\uff09\u3002 \u6b64\u5916\uff0c\u5339\u5eb7\u5947\u62dc\u55ae\u6297200 mg\u7d44\u548c600 mg\u7d44\u9054\u5230\u75c7\u72c0\u7de9\u89e3\u3001\u5167\u93e1\u7de9\u89e3\u6216\u9ecf\u819c\u6108\u5408\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u5747\u9ad8\u65bc\u5b89\u6170\u5291\u7d44\u3002 \u5b89\u5168\u6027\u65b9\u9762\uff0c\u5339\u5eb7\u5947\u62dc\u55ae\u6297\u7d44\u7e3d\u9ad4\u5b89\u5168\u6027\u826f\u597d\uff0c\u672a\u767c\u73fe\u65b0\u589e\u5b89\u5168\u6027\u4fe1\u865f\uff0c\u8207\u65e2\u5f80\u7814\u7a76\u548c\u540c\u985e\u7522\u54c1\u7684\u5b89\u5168\u6027\u7279\u5f81\u76f8\u4f3c\u3002 \u622a\u81f3\u76ee\u524d\u7814\u7a76\u7dad\u6301\u671f\u4ecd\u5728\u9032\u884c\u4e2d\uff0c\u9032\u5165\u7dad\u6301\u671f\u7684\u53d7\u8a66\u8005\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\u3001\u81e8\u5e8a\u61c9\u7b54\u3001\u75c7\u72c0\u7de9\u89e3\u3001\u5167\u93e1\u7de9\u89e3\u6216\u9ecf\u819c\u6108\u5408\u7684\u6bd4\u4f8b\u76f8\u8f03\u8a98\u5c0e\u671f\u5747\u6709\u4e0d\u540c\u7a0b\u5ea6\u7684\u7e7c\u7e8c\u63d0\u5347\u3002\u5b8c\u6574\u6578\u64da\u8a08\u5283\u5728\u672a\u4f86\u5b78\u8853\u5927\u6703\u6216\u671f\u520a\u6295\u7a3f\u767c\u8868\u3002 \u8a72\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u4e2d\u5c71\u5927\u5b78\u9644\u5c6c\u7b2c\u4e00\u91ab\u9662\u9673\u65fb\u6e56\u6559\u6388\u8868\u793a\uff1a\u300c\u6f70\u760d\u6027\u7d50\u8178\u708e\u662f\u4e00\u7a2e\u6162\u6027\u3001\u5fa9\u767c\u6027\u7684\u7d50\u76f4\u8178\u9ecf\u819c\u708e\u75c7\u75be\u75c5\uff0c\u8207\u907a\u50b3\u3001\u74b0\u5883\u548c\u514d\u75ab\u7cfb\u7d71\u56e0\u7d20\u76f8\u4e92\u4f5c\u7528\u6709\u95dc\u3002\u5e38\u898b\u75c7\u72c0\u5305\u62ec\u8179\u75db\u3001\u8179\u7009\u3001\u4fbf\u8840\u3001\u9ad4\u91cd\u6e1b\u8f15\u548c\u75b2\u52de\u7b49\u3002\u73fe\u6709\u6cbb\u7642\u624b\u6bb5\u4e3b\u8981\u96c6\u4e2d\u5728\u63a7\u5236\u708e\u75c7\u3001\u7de9\u89e3\u75c7\u72c0\u548c\u7dad\u6301\u7de9\u89e3\u3002\u76e1\u7ba1\u6cbb\u7642\u65b9\u6cd5\u4e0d\u65b7\u9032\u6b65\uff0c\u4f46\u4ecd\u9762\u81e8\u8af8\u591a\u6311\u6230\uff0c\u4e9f\u5f85\u65b0\u7684\u6cbb\u7642\u624b\u6bb5\u3002\u6211\u5f88\u9ad8\u8208\u770b\u5230\u5339\u5eb7\u5947\u62dc\u55ae\u6297\u6cbb\u7642\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178II\u671f\u81e8\u5e8a\u7814\u7a76\u4e2d\u9054\u6210\u4e3b\u8981\u7d42\u9ede\uff0c\u53d7\u8a66\u8005\u7372\u5f97\u986f\u8457\u7684\u8a98\u5c0e\u671f\u81e8\u5e8a\u7372\u76ca\uff0c\u540c\u6642\u5b89\u5168\u6027\u826f\u597d\u3002\u6211\u671f\u5f85\u672a\u4f86\u7522\u54c1\u9806\u5229\u958b\u767c\uff0c\u70ba\u4e2d\u570b\u6f70\u760d\u6027\u7d50\u8178\u708e\u60a3\u8005\u63d0\u4f9b\u66f4\u591a\u7684\u6cbb\u7642\u9078\u64c7\u3002\u300d \u4fe1\u9054\u751f\u7269\u5236\u85e5\u96c6\u5718\u81e8\u5e8a\u9ad8\u7d1a\u526f\u7e3d\u88c1\u9322\u9433\u535a\u58eb\u8868\u793a\uff1a\u300c\u6f70\u760d\u6027\u7d50\u8178\u708e\u4f5c\u70ba\u4e00\u7a2e\u6162\u6027\u708e\u75c7\u6027\u75be\u75c5\uff0c\u9664\u537b\u5c0d\u8eab\u9ad4\u5065\u5eb7\u7684\u640d\u5bb3\uff0c\u5176\u5c0d\u60a3\u8005\u7684\u65e5\u5e38\u751f\u6d3b\u4e5f\u6709\u56b4\u91cd\u5e72\u64fe\uff0c\u5c0d\u60a3\u8005\u7684\u5fc3\u7406\u7522\u751f\u5de8\u5927\u7684\u8ca0\u9762\u5f71\u97ff\u3002\u8fd1\u5e74\u4f86\uff0c\u4ee5IL-23\u70ba\u9776\u9ede\u7684\u65b0\u4e00\u4ee3\u85e5\u7269\u56e0\u5176\u5728\u6f70\u760d\u6027\u7d50\u8178\u708e\u60a3\u8005\u6cbb\u7642\u4e2d\u5353\u8d8a\u7684\u7642\u6548\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u5f15\u767c\u95dc\u6ce8\uff1b\u76ee\u524d\uff0c\u570b\u5167\u5e02\u5834\u4e0a\u5c1a\u7121IL-23p19\u9776\u9ede\u85e5\u7269\u7372\u6279\u6cbb\u7642\u6f70\u760d\u6027\u7d50\u8178\u708e\uff0c\u672c\u7814\u7a76\u662f\u7b2c\u4e00\u500b\u7531\u570b\u5167\u4f01\u696d\u81ea\u4e3b\u7814\u767c\u7684IL-23p19\u55ae\u6297\u6cbb\u7642\u6f70\u760d\u6027\u7d50\u8178\u708e\u7684\u81e8\u5e8a\u7814\u7a76\u3002\u4fe1\u9054\u751f\u7269\u81ea\u4e3b\u7814\u767c\u7684\u5339\u5eb7\u5947\u62dc\u55ae\u6297\u5df2\u7d93\u5728\u6591\u584a\u72c0\u9280\u5c51\u75c5\u53d6\u5f97\u6210\u529f\uff0c\u672c\u6b21\u5728\u6f70\u760d\u6027\u7d50\u8178\u708eII\u671f\u81e8\u5e8a\u7814\u7a76\u4e2d\u7684\u7d50\u679c\u512a\u7570\uff0c\u8a98\u5c0e\u671f\u7642\u6548\u3001\u7dad\u6301\u671f\u7684\u521d\u6b65\u7642\u6548\u53ca\u5176\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u4f7f\u6211\u5011\u66f4\u6df1\u53d7\u9f13\u821e\uff0c\u6211\u5011\u671f\u5f85\u4fe1\u9054\u751f\u7269\u66f4\u591a\u53ef\u53ca\u6027\u826f\u597d\u4e14\u9ad8\u8cea\u91cf\u7684\u5275\u65b0\u751f\u7269\u85e5\u53ef\u4ee5\u65e9\u65e5\u60e0\u53ca\u5ee3\u5927\u60a3\u8005\u3002\u300d \u95dc\u65bc\u6f70\u760d\u6027\u7d50\u8178\u708e \u6f70\u760d\u6027\u7d50\u8178\u708e\u70ba\u4e00\u7a2e\u6162\u6027\u975e\u7279\u7570\u6027\u8178\u9053\u708e\u75c7\u6027\u75be\u75c5\uff08IBD\uff09\uff0c\u4ee5\u7d50\u8178\u548c\u76f4\u8178\u708e\u75c7\u70ba\u7279\u5f81\u3002\u5178\u578b\u75c7\u72c0\u70ba\u53cd\u5fa9\u767c\u4f5c\u7684\u8179\u7009\u3001\u7c98\u6db2\u81bf\u8840\u4fbf\u4f34\u8179\u75db\u3001\u88e1\u6025\u5f8c\u91cd\u3002\u6f70\u760d\u6027\u7d50\u8178\u708e\u56b4\u91cd\u5a01\u8105\u8eab\u9ad4\u5065\u5eb7\u4e26\u5c0d\u65e5\u5e38\u751f\u6d3b\u548c\u5fc3\u7406\u5e36\u4f86\u5f71\u97ff\u3002\u6f70\u760d\u6027\u7d50\u8178\u708e\u597d\u767c\u65bc\u4e2d\u9752\u5e74\uff0c\u5728\u4e2d\u570b\uff0c\u8fd120\u5e74\u4f86\u5c31\u8a3a\u4eba\u6578\u5448\u5feb\u901f\u4e0a\u5347\u8da8\u52e2\uff0c\u60a3\u75c5\u7387\u70ba11.6\/10\u842c\u3002\u6f70\u760d\u6027\u7d50\u8178\u708e\u7684\u81e8\u5e8a\u6cbb\u7642\u624b\u6bb5\u4ee5\u85e5\u7269\u548c\u624b\u8853\u6cbb\u7642\u70ba\u4e3b\uff0c\u786b\u560c\u5464\u85e5\u7269\u70ba\u6700\u50b3\u7d71\u7684\u6cbb\u7642\u514d\u75ab\u6291\u5236\u5291\uff0c\u4f46\u4e0d\u826f\u53cd\u61c9\u767c\u751f\u7387\u9ad8\u3002\u751f\u7269\u5236\u5291\u65b9\u9762\uff0c\u6297TNF-\u03b1\u6cbb\u7642\u5b58\u5728\u85e5\u7269\u514d\u75ab\u539f\u6027\u5c0e\u81f4\u7684\u5931\u53bb\u61c9\u7b54\u554f\u984c\u3002\u8fd1\u5e74\u4f86\u91dd\u5c0dIL-12\u3001IL-23\u7b49\u9776\u9ede\u7684\u85e5\u7269\u5728\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u4e0a\u5c55\u73fe\u4e86\u512a\u52e2\uff0c\u4f46\u76ee\u524d\u6211\u570b\u4ecd\u6c92\u6709IL-23p19\u9776\u9ede\u85e5\u7269\u7372\u6279\u7528\u65bc\u6cbb\u7642\u6f70\u760d\u6027\u7d50\u8178\u708e\uff0c\u81e8\u5e8a\u4e0a\u4ecd\u5b58\u5728\u5de8\u5927\u7684\u9700\u6c42\u3002 \u95dc\u65bc\u5339\u5eb7\u5947\u62dc\u55ae\u6297\uff08IBI112\uff09 \u5339\u5eb7\u5947\u62dc\u55ae\u6297\uff08IBI112\uff09\u70ba\u91cd\u7d44\u6297\u767d\u4ecb\u7d2023p19\u4e9e\u57fa\uff08IL-23p19\uff09\u6297\u9ad4\u6ce8\u5c04\u6db2\uff0c\u662f\u7531\u4fe1\u9054\u751f\u7269\u81ea\u4e3b\u7814\u767c\uff0c\u5177\u6709\u81ea\u4e3b\u77e5\u8b58\u7522\u6b0a\u7684\u4e00\u7a2e\u55ae\u514b\u9686\u6297\u9ad4\uff0c\u7279\u7570\u6027\u7d50\u5408IL-23p19\u4e9e\u57fa\u3002\u901a\u904e\u963b\u6b62IL-23\u8207\u7d30\u80de\u8868\u9762\u53d7\u9ad4\u7d50\u5408\uff0c\u963b\u65b7IL-23\u53d7\u9ad4\u4ecb\u5c0e\u4fe1\u865f\u901a\u8def\u767c\u63ee\u6297\u708e\u4f5c\u7528\u3002IBI112\u6709\u671b\u70ba\u9280\u5c51\u75c5\u3001\u6f70\u760d\u6027\u8178\u708e\u548c\u5176\u4ed6\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u60a3\u8005\u63d0\u4f9b\u66f4\u6709\u6548\u3001\u66f4\u9577\u7d66\u85e5\u5468\u671f\u7684\u6cbb\u7642\u65b9\u6848\u3002 \u5339\u5eb7\u5947\u62dc\u55ae\u6297\u7576\u524d\u958b\u5c55\u4e86\u591a\u9805\u81e8\u5e8a\u7814\u7a76\uff0c\u5305\u62ec\uff1a \u5728\u4e2d\u91cd\u5ea6\u9280\u5c51\u75c5\u60a3\u8005\u4e2d\u958b\u5c55\u7684\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff08CLEAR-1\uff09\uff0c\u5df2\u65bc2024\u5e745\u6708\u9054\u6210\u7d42\u9ede\uff1b \u5728\u4e2d\u91cd\u5ea6\u9280\u5c51\u75c5\u60a3\u8005\u4e2d\u958b\u5c55\u7684\u96a8\u6a5f\u64a4\u85e5\u518d\u6cbb\u7642\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff1b \u5728\u4e2d\u91cd\u5ea6\u9280\u5c51\u75c5\u60a3\u8005\u4e2d\u958b\u5c55\u7684\u751f\u7269\u5236\u5291\u6cbb\u7642\u8f49\u5339\u5eb7\u5947\u62dc\u55ae\u6297\u6cbb\u7642\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\uff1b \u5728\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\u60a3\u8005\u4e2d\u958b\u5c55\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\u3002 2024\u5e749\u6708\uff0c\u5339\u5eb7\u5947\u62dc\u55ae\u6297\u7684\u9996\u500bNDA\u7372NMPA\u53d7\u7406\uff0c\u7528\u65bc\u6cbb\u7642\u4e2d\u91cd\u5ea6\u6591\u584a\u72c0\u9280\u5c51\u75c5\u3002 \u95dc\u65bc\u4fe1\u9054\u751f\u7269 \u300c\u59cb\u65bc\u4fe1\uff0c\u9054\u65bc\u884c\u300d\uff0c\u958b\u767c\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8cea\u91cf\u751f\u7269\u85e5\uff0c\u662f\u4fe1\u9054\u751f\u7269\u7684\u4f7f\u547d\u548c\u76ee\u6a19\u3002\u4fe1\u9054\u751f\u7269\u6210\u7acb\u65bc2011\u5e74\uff0c\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u7684\u5275\u65b0\u85e5\u7269\uff0c\u8b93\u6211\u5011\u7684\u5de5\u4f5c\u60e0\u53ca\u66f4\u591a\u7684\u751f\u547d\u3002\u516c\u53f8\u5df2\u670911\u500b\u7522\u54c1\u7372\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c\u5b83\u5011\u5206\u5225\u662f\u4fe1\u8fea\u5229\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u4f2f\u8212\u00ae\uff09\uff0c\u8c9d\u4f10\u73e0\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u6538\u540c\u00ae\uff09\uff0c\u963f\u9054\u6728\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u8607\u7acb\u4fe1\u00ae\uff09\uff0c\u5229\u59a5\u6614\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u4f2f\u83ef\u00ae\uff09\uff0c\u4f69\u7c73\u66ff\u5c3c\u7247\uff08\u9054\u4f2f\u5766\u00ae\uff09\uff0c\u5967\u96f7\u5df4\u66ff\u5c3c\u7247\uff08\u8010\u7acb\u514b\u00ae\uff09\uff0c\u96f7\u83ab\u897f\u5c24\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u5e0c\u5189\u64c7\u00ae\uff09\uff0c\u585e\u666e\u66ff\u5c3c\u81a0\u56ca\uff08\u777f\u59a5\u00ae\uff09\uff0c\u4f0a\u57fa\u5967\u4f96\u8cfd\u6ce8\u5c04\u6db2\uff08\u798f\u53ef\u8607\u00ae\uff09\uff0c\u6258\u840a\u897f\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u4fe1\u5fc5\u6a02\u00ae\uff09\u548c\u6c1f\u6fa4\u96f7\u585e\u7247\uff08\u9054\u4f2f\u7279\u00ae\uff09\u3002\u76ee\u524d\uff0c\u540c\u6642\u9084\u67095\u500b\u54c1\u7a2e\u5728NMPA\u5be9\u8a55\u4e2d\uff0c3\u500b\u65b0\u85e5\u5206\u5b50\u9032\u5165III\u671f\u6216\u95dc\u9375\u6027\u81e8\u5e8a\u7814\u7a76\uff0c\u53e6\u5916\u9084\u670917\u500b\u65b0\u85e5\u54c1\u7a2e\u5df2\u9032\u5165\u81e8\u5e8a\u7814\u7a76\u3002 \u516c\u53f8\u5df2\u8207\u79ae\u4f86\u3001\u7f85\u6c0f\u3001\u8cfd\u8afe\u83f2\u3001Adimab\u3001Incyte\u548cMD Anderson \u764c\u75c7\u4e2d\u5fc3\u7b49\u570b\u969b\u5408\u4f5c\u65b9\u9054\u621030\u591a\u9805\u6230\u7565\u5408\u4f5c\u3002\u4fe1\u9054\u751f\u7269\u5728\u4e0d\u65b7\u81ea\u7814\u5275\u65b0\u85e5\u7269\u3001\u8b00\u6c42\u81ea\u8eab\u767c\u5c55\u7684\u540c\u6642\uff0c\u79c9\u627f\u7d93\u6fdf\u5efa\u8a2d\u4ee5\u4eba\u6c11\u70ba\u4e2d\u5fc3\u7684\u767c\u5c55\u601d\u60f3\u3002\u591a\u5e74\u4f86\uff0c\u59cb\u7d42\u5fc3\u61f7\u79d1\u5b78\u5584\u5ff5\uff0c\u5805\u5b88\u300c\u4ee5\u60a3\u8005\u70ba\u4e2d\u5fc3\u300d\uff0c\u5fc3\u7cfb\u60a3\u8005\u4e26\u95dc\u6ce8\u60a3\u8005\u5bb6\u5ead\uff0c\u7a4d\u6975\u5c65\u884c\u793e\u6703\u8cac\u4efb\u3002\u516c\u53f8\u9678\u7e8c\u767c\u8d77\u3001\u53c3\u8207\u4e86\u591a\u9805\u85e5\u54c1\u516c\u76ca\u63f4\u52a9\u9805\u76ee\uff0c\u8b93\u8d8a\u4f86\u8d8a\u591a\u7684\u60a3\u8005\u80fd\u5920\u5f97\u76ca\u65bc\u751f\u547d\u79d1\u5b78\u7684\u9032\u6b65\uff0c\u8cb7\u5f97\u5230\u3001\u7528\u5f97\u8d77\u9ad8\u8cea\u91cf\u7684\u751f\u7269\u85e5\u3002\u622a\u81f3\u76ee\u524d\uff0c\u4fe1\u9054\u751f\u7269\u60a3\u8005\u63f4\u52a9\u9805\u76ee\u5df2\u60e0\u53ca17\u4f59\u842c\u666e\u901a\u60a3\u8005\uff0c\u85e5\u7269\u6350\u8d08\u7e3d\u50f9\u503c34\u5104\u5143\u4eba\u6c11\u5e63\u3002\u4fe1\u9054\u751f\u7269\u5e0c\u671b\u548c\u5927\u5bb6\u4e00\u8d77\u52aa\u529b\uff0c\u63d0\u9ad8\u4e2d\u570b\u751f\u7269\u5236\u85e5\u7522\u696d\u7684\u767c\u5c55\u6c34\u5e73\uff0c\u4ee5\u6eff\u8db3\u767e\u59d3\u7528\u85e5\u53ef\u53ca\u6027\u548c\u4eba\u6c11\u5c0d\u751f\u547d\u5065\u5eb7\u7f8e\u597d\u9858\u671b\u7684\u8ffd\u6c42\u3002 \u8a73\u60c5\u8acb\u8a2a\u554f\u516c\u53f8\u7db2\u7ad9\uff1awww.innoventbio.com\u6216\u516c\u53f8\u9818\u82f1\u8cec\u865f\u3002 \u8072\u660e\uff1a\u4fe1\u9054\u4e0d\u63a8\u85a6\u4efb\u4f55\u672a\u7372\u6279\u7684\u85e5\u54c1\/\u9069\u61c9\u75c7\u4f7f\u7528\u3002 \u524d\u77bb\u6027\u8072\u660e \u672c\u65b0\u805e\u7a3f\u6240\u767c\u5e03\u7684\u4fe1\u606f\u4e2d\u53ef\u80fd\u6703\u5305\u542b\u67d0\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u3002\u9019\u4e9b\u8868\u8ff0\u672c\u8cea\u4e0a\u5177\u6709\u76f8\u7576\u98a8\u96aa\u548c\u4e0d\u78ba\u5b9a\u6027\u3002\u5728\u4f7f\u7528\u300c\u9810\u671f\u300d\u3001\u300c\u76f8\u4fe1\u300d\u3001\u300c\u9810\u6e2c\u300d\u3001\u300c\u671f\u671b\u300d\u3001\u300c\u6253\u7b97\u300d\u53ca\u5176\u4ed6\u985e\u4f3c\u8a5e\u8a9e\u9032\u884c\u8868\u8ff0\u6642\uff0c\u51e1\u8207\u672c\u516c\u53f8\u6709\u95dc\u7684\uff0c\u76ee\u7684\u5747\u662f\u8981\u6307\u660e\u5176\u5c6c\u524d\u77bb\u6027\u8868\u8ff0\u3002\u672c\u516c\u53f8\u4e26\u7121\u7fa9\u52d9\u4e0d\u65b7\u5730\u66f4\u65b0\u9019\u4e9b\u9810\u6e2c\u6027\u9673\u8ff0\u3002 \u9019\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u4e43\u57fa\u65bc\u672c\u516c\u53f8\u7ba1\u7406\u5c64\u5728\u505a\u51fa\u8868\u8ff0\u6642\u5c0d\u672a\u4f86\u4e8b\u52d9\u7684\u73fe\u6709\u770b\u6cd5\u3001\u5047\u8a2d\u3001\u671f\u671b\u3001\u4f30\u8a08\u3001\u9810\u6e2c\u548c\u7406\u89e3\u3002\u9019\u4e9b\u8868\u8ff0\u4e26\u975e\u5c0d\u672a\u4f86\u767c\u5c55\u7684\u4fdd\u8b49\uff0c\u6703\u53d7\u5230\u98a8\u96aa\u3001\u4e0d\u78ba\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u97ff\uff0c\u6709\u4e9b\u4e43\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u8303\u570d\uff0c\u96e3\u4ee5\u9810\u8a08\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u5011\u7684\u696d\u52d9\u3001\u7af6\u722d\u74b0\u5883\u3001\u653f\u6cbb\u3001\u7d93\u6fdf\u3001\u6cd5\u5f8b\u548c\u793e\u6703\u60c5\u6cc1\u7684\u672a\u4f86\u8b8a\u5316\u53ca\u767c\u5c55\u7684\u5f71\u97ff\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u6703\u8207\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8cc7\u6599\u6709\u8f03\u5927\u5dee\u5225\u3002<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_generate-full-width-content":"","spay_email":"","footnotes":""},"categories":[1],"tags":[],"yoast_head":"\n\u4fe1\u9054\u751f\u7269\u5ba3\u5e03\u5339\u5eb7\u5947\u62dc\u55ae\u6297\uff08IL-23p19\u6297\u9ad4\uff09\u6cbb\u7642\u6f70\u760d\u6027\u7d50\u8178\u708e\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\u9054\u6210\u4e3b\u8981\u7d42\u9ede - \u9999\u6e2f\u7279\u8a31\u7d93\u71df<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.franchise.com.hk\/en\/%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%8c%b9%e5%ba%b7%e5%a5%87%e6%8b%9c%e5%96%ae%e6%8a%97%ef%bc%88il-23p19%e6%8a%97%e9%ab%94%ef%bc%89%e6%b2%bb%e7%99%82%e6%bd%b0%e7%98%8d%e6%80%a7\/22482\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u4fe1\u9054\u751f\u7269\u5ba3\u5e03\u5339\u5eb7\u5947\u62dc\u55ae\u6297\uff08IL-23p19\u6297\u9ad4\uff09\u6cbb\u7642\u6f70\u760d\u6027\u7d50\u8178\u708e\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\u9054\u6210\u4e3b\u8981\u7d42\u9ede - \u9999\u6e2f\u7279\u8a31\u7d93\u71df\" \/>\n<meta property=\"og:description\" content=\"\u7f8e\u570b\u820a\u91d1\u5c71\u548c\u4e2d\u570b\u8607\u5dde2024\u5e7410\u670817\u65e5 \/\u7f8e\u901a\u793e\/ — \u4fe1\u9054\u751f\u7269\u5236\u85e5\u96c6\u5718\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u80a1\u7968\u4ee3\u78bc\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u53ca\u5fc3\u8840\u7ba1\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u5275\u65b0\u85e5\u7269\u7684\u751f\u7269\u5236\u85e5\u516c\u53f8\u5ba3\u5e03\uff1a\u5339\u5eb7\u5947\u62dc\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u91cd\u7d44\u6297\u767d\u4ecb\u7d2023p19\u4e9e\u57fa\uff08IL-23p19\uff09\u6297\u9ad4\uff0c\u7814\u767c\u4ee3\u865f\uff1aIBI112\uff09\u5728\u4e2d\u570b\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\uff08UC\uff09\u53d7\u8a66\u8005\u4e2d\u958b\u5c55\u7684\u4e00\u9805\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\uff08Clinicaltrials.gov, NCT05377580\uff09\u4e2d\u9054\u6210\u4e3b\u8981\u7d42\u9ede\u3002 \u8a72\u7814\u7a76\u65e8\u5728\u8a55\u50f9\u5339\u5eb7\u5947\u62dc\u55ae\u6297\u8a98\u5c0e\u6cbb\u7642\u548c\u7dad\u6301\u6cbb\u7642\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\uff08\u5165\u9078\u6a19\u51c6\u70ba\u6539\u826fMayo\u8a55\u52064\uff5e9\u5206\uff0c\u4e14\u5176\u4e2d\u5167\u93e1\u8a55\u5206\u22652\u5206\uff09\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u7814\u7a76\u5171\u5165\u7d44150\u4f8b\u53d7\u8a66\u8005\uff0c\u63091:1:1\u7684\u6bd4\u4f8b\u96a8\u6a5f\u63a5\u53d7\u5b89\u6170\u5291\u3001\u5339\u5eb7\u5947\u62dc\u55ae\u6297200 mg\u6216\u5339\u5eb7\u5947\u62dc\u55ae\u6297600 mg\u7b2c0\u30014\u30018\u5468\u975c\u8108\u8f38\u6ce8\u6cbb\u7642\uff0c\u8a98\u5c0e\u6cbb\u7642\u5f8c\u91c7\u7528200 mg\u5339\u5eb7\u5947\u62dc\u55ae\u6297\u6bcf4\u5468\u6216\u6bcf8\u5468\u76ae\u4e0b\u6ce8\u5c04\u9032\u884c\u7dad\u6301\u6cbb\u7642\u3002\u7814\u7a76\u4e3b\u8981\u7d42\u9ede\u70ba\u8a98\u5c0e\u6cbb\u7642\u671f\u7b2c12\u5468\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\uff08\u5b9a\u7fa9\u70ba\u6539\u826fMayo\u8a55\u5206\u7684\u4fbf\u8840\u70ba0\u5206\uff0c\u6392\u4fbf\u6b21\u6578\u22641\u5206\u4ee5\u53ca\u5167\u93e1\u767c\u73fe\u22641\u5206\uff09\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u3002\u6b21\u8981\u7d42\u9ede\u5305\u62ec\u8a98\u5c0e\u6cbb\u7642\u671f\u7b2c12\u5468\u9054\u5230\u81e8\u5e8a\u61c9\u7b54\u3001\u75c7\u72c0\u7de9\u89e3\u3001\u5167\u93e1\u7de9\u89e3\u6216\u9ecf\u819c\u6108\u5408\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u7b49\u3002 \u7814\u7a76\u9054\u6210\u4e3b\u8981\u7d42\u9ede\u548c\u6b21\u8981\u7d42\u9ede\uff0c\u5373\uff1a \u8a98\u5c0e\u6cbb\u7642\u671f\u7b2c12\u5468\u6642\uff0c\u5339\u5eb7\u5947\u62dc\u55ae\u6297200 mg\u7d44\u548c600 mg\u7d44\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u5206\u5225\u662f20.0%\u548c14.0%\uff0c\u5747\u986f\u8457\u9ad8\u65bc\u5b89\u6170\u5291\u7d44\uff082.0%\uff1bp <0.05\uff09\u3002 \u5339\u5eb7\u5947\u62dc\u55ae\u6297200 mg\u7d44\u548c600 mg\u7d44\u9054\u5230\u81e8\u5e8a\u61c9\u7b54\u7684\u53d7\u8a66\u8005\u5206\u5225\u70ba54.0%\u548c68.0%\uff0c\u5747\u986f\u8457\u9ad8\u65bc\u5b89\u6170\u5291\u7d44\uff0822.0%\uff1bp <0.001\uff09\u3002 \u6b64\u5916\uff0c\u5339\u5eb7\u5947\u62dc\u55ae\u6297200 mg\u7d44\u548c600 mg\u7d44\u9054\u5230\u75c7\u72c0\u7de9\u89e3\u3001\u5167\u93e1\u7de9\u89e3\u6216\u9ecf\u819c\u6108\u5408\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u5747\u9ad8\u65bc\u5b89\u6170\u5291\u7d44\u3002 \u5b89\u5168\u6027\u65b9\u9762\uff0c\u5339\u5eb7\u5947\u62dc\u55ae\u6297\u7d44\u7e3d\u9ad4\u5b89\u5168\u6027\u826f\u597d\uff0c\u672a\u767c\u73fe\u65b0\u589e\u5b89\u5168\u6027\u4fe1\u865f\uff0c\u8207\u65e2\u5f80\u7814\u7a76\u548c\u540c\u985e\u7522\u54c1\u7684\u5b89\u5168\u6027\u7279\u5f81\u76f8\u4f3c\u3002 \u622a\u81f3\u76ee\u524d\u7814\u7a76\u7dad\u6301\u671f\u4ecd\u5728\u9032\u884c\u4e2d\uff0c\u9032\u5165\u7dad\u6301\u671f\u7684\u53d7\u8a66\u8005\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\u3001\u81e8\u5e8a\u61c9\u7b54\u3001\u75c7\u72c0\u7de9\u89e3\u3001\u5167\u93e1\u7de9\u89e3\u6216\u9ecf\u819c\u6108\u5408\u7684\u6bd4\u4f8b\u76f8\u8f03\u8a98\u5c0e\u671f\u5747\u6709\u4e0d\u540c\u7a0b\u5ea6\u7684\u7e7c\u7e8c\u63d0\u5347\u3002\u5b8c\u6574\u6578\u64da\u8a08\u5283\u5728\u672a\u4f86\u5b78\u8853\u5927\u6703\u6216\u671f\u520a\u6295\u7a3f\u767c\u8868\u3002 \u8a72\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u4e2d\u5c71\u5927\u5b78\u9644\u5c6c\u7b2c\u4e00\u91ab\u9662\u9673\u65fb\u6e56\u6559\u6388\u8868\u793a\uff1a\u300c\u6f70\u760d\u6027\u7d50\u8178\u708e\u662f\u4e00\u7a2e\u6162\u6027\u3001\u5fa9\u767c\u6027\u7684\u7d50\u76f4\u8178\u9ecf\u819c\u708e\u75c7\u75be\u75c5\uff0c\u8207\u907a\u50b3\u3001\u74b0\u5883\u548c\u514d\u75ab\u7cfb\u7d71\u56e0\u7d20\u76f8\u4e92\u4f5c\u7528\u6709\u95dc\u3002\u5e38\u898b\u75c7\u72c0\u5305\u62ec\u8179\u75db\u3001\u8179\u7009\u3001\u4fbf\u8840\u3001\u9ad4\u91cd\u6e1b\u8f15\u548c\u75b2\u52de\u7b49\u3002\u73fe\u6709\u6cbb\u7642\u624b\u6bb5\u4e3b\u8981\u96c6\u4e2d\u5728\u63a7\u5236\u708e\u75c7\u3001\u7de9\u89e3\u75c7\u72c0\u548c\u7dad\u6301\u7de9\u89e3\u3002\u76e1\u7ba1\u6cbb\u7642\u65b9\u6cd5\u4e0d\u65b7\u9032\u6b65\uff0c\u4f46\u4ecd\u9762\u81e8\u8af8\u591a\u6311\u6230\uff0c\u4e9f\u5f85\u65b0\u7684\u6cbb\u7642\u624b\u6bb5\u3002\u6211\u5f88\u9ad8\u8208\u770b\u5230\u5339\u5eb7\u5947\u62dc\u55ae\u6297\u6cbb\u7642\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178II\u671f\u81e8\u5e8a\u7814\u7a76\u4e2d\u9054\u6210\u4e3b\u8981\u7d42\u9ede\uff0c\u53d7\u8a66\u8005\u7372\u5f97\u986f\u8457\u7684\u8a98\u5c0e\u671f\u81e8\u5e8a\u7372\u76ca\uff0c\u540c\u6642\u5b89\u5168\u6027\u826f\u597d\u3002\u6211\u671f\u5f85\u672a\u4f86\u7522\u54c1\u9806\u5229\u958b\u767c\uff0c\u70ba\u4e2d\u570b\u6f70\u760d\u6027\u7d50\u8178\u708e\u60a3\u8005\u63d0\u4f9b\u66f4\u591a\u7684\u6cbb\u7642\u9078\u64c7\u3002\u300d \u4fe1\u9054\u751f\u7269\u5236\u85e5\u96c6\u5718\u81e8\u5e8a\u9ad8\u7d1a\u526f\u7e3d\u88c1\u9322\u9433\u535a\u58eb\u8868\u793a\uff1a\u300c\u6f70\u760d\u6027\u7d50\u8178\u708e\u4f5c\u70ba\u4e00\u7a2e\u6162\u6027\u708e\u75c7\u6027\u75be\u75c5\uff0c\u9664\u537b\u5c0d\u8eab\u9ad4\u5065\u5eb7\u7684\u640d\u5bb3\uff0c\u5176\u5c0d\u60a3\u8005\u7684\u65e5\u5e38\u751f\u6d3b\u4e5f\u6709\u56b4\u91cd\u5e72\u64fe\uff0c\u5c0d\u60a3\u8005\u7684\u5fc3\u7406\u7522\u751f\u5de8\u5927\u7684\u8ca0\u9762\u5f71\u97ff\u3002\u8fd1\u5e74\u4f86\uff0c\u4ee5IL-23\u70ba\u9776\u9ede\u7684\u65b0\u4e00\u4ee3\u85e5\u7269\u56e0\u5176\u5728\u6f70\u760d\u6027\u7d50\u8178\u708e\u60a3\u8005\u6cbb\u7642\u4e2d\u5353\u8d8a\u7684\u7642\u6548\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u5f15\u767c\u95dc\u6ce8\uff1b\u76ee\u524d\uff0c\u570b\u5167\u5e02\u5834\u4e0a\u5c1a\u7121IL-23p19\u9776\u9ede\u85e5\u7269\u7372\u6279\u6cbb\u7642\u6f70\u760d\u6027\u7d50\u8178\u708e\uff0c\u672c\u7814\u7a76\u662f\u7b2c\u4e00\u500b\u7531\u570b\u5167\u4f01\u696d\u81ea\u4e3b\u7814\u767c\u7684IL-23p19\u55ae\u6297\u6cbb\u7642\u6f70\u760d\u6027\u7d50\u8178\u708e\u7684\u81e8\u5e8a\u7814\u7a76\u3002\u4fe1\u9054\u751f\u7269\u81ea\u4e3b\u7814\u767c\u7684\u5339\u5eb7\u5947\u62dc\u55ae\u6297\u5df2\u7d93\u5728\u6591\u584a\u72c0\u9280\u5c51\u75c5\u53d6\u5f97\u6210\u529f\uff0c\u672c\u6b21\u5728\u6f70\u760d\u6027\u7d50\u8178\u708eII\u671f\u81e8\u5e8a\u7814\u7a76\u4e2d\u7684\u7d50\u679c\u512a\u7570\uff0c\u8a98\u5c0e\u671f\u7642\u6548\u3001\u7dad\u6301\u671f\u7684\u521d\u6b65\u7642\u6548\u53ca\u5176\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u4f7f\u6211\u5011\u66f4\u6df1\u53d7\u9f13\u821e\uff0c\u6211\u5011\u671f\u5f85\u4fe1\u9054\u751f\u7269\u66f4\u591a\u53ef\u53ca\u6027\u826f\u597d\u4e14\u9ad8\u8cea\u91cf\u7684\u5275\u65b0\u751f\u7269\u85e5\u53ef\u4ee5\u65e9\u65e5\u60e0\u53ca\u5ee3\u5927\u60a3\u8005\u3002\u300d \u95dc\u65bc\u6f70\u760d\u6027\u7d50\u8178\u708e \u6f70\u760d\u6027\u7d50\u8178\u708e\u70ba\u4e00\u7a2e\u6162\u6027\u975e\u7279\u7570\u6027\u8178\u9053\u708e\u75c7\u6027\u75be\u75c5\uff08IBD\uff09\uff0c\u4ee5\u7d50\u8178\u548c\u76f4\u8178\u708e\u75c7\u70ba\u7279\u5f81\u3002\u5178\u578b\u75c7\u72c0\u70ba\u53cd\u5fa9\u767c\u4f5c\u7684\u8179\u7009\u3001\u7c98\u6db2\u81bf\u8840\u4fbf\u4f34\u8179\u75db\u3001\u88e1\u6025\u5f8c\u91cd\u3002\u6f70\u760d\u6027\u7d50\u8178\u708e\u56b4\u91cd\u5a01\u8105\u8eab\u9ad4\u5065\u5eb7\u4e26\u5c0d\u65e5\u5e38\u751f\u6d3b\u548c\u5fc3\u7406\u5e36\u4f86\u5f71\u97ff\u3002\u6f70\u760d\u6027\u7d50\u8178\u708e\u597d\u767c\u65bc\u4e2d\u9752\u5e74\uff0c\u5728\u4e2d\u570b\uff0c\u8fd120\u5e74\u4f86\u5c31\u8a3a\u4eba\u6578\u5448\u5feb\u901f\u4e0a\u5347\u8da8\u52e2\uff0c\u60a3\u75c5\u7387\u70ba11.6\/10\u842c\u3002\u6f70\u760d\u6027\u7d50\u8178\u708e\u7684\u81e8\u5e8a\u6cbb\u7642\u624b\u6bb5\u4ee5\u85e5\u7269\u548c\u624b\u8853\u6cbb\u7642\u70ba\u4e3b\uff0c\u786b\u560c\u5464\u85e5\u7269\u70ba\u6700\u50b3\u7d71\u7684\u6cbb\u7642\u514d\u75ab\u6291\u5236\u5291\uff0c\u4f46\u4e0d\u826f\u53cd\u61c9\u767c\u751f\u7387\u9ad8\u3002\u751f\u7269\u5236\u5291\u65b9\u9762\uff0c\u6297TNF-\u03b1\u6cbb\u7642\u5b58\u5728\u85e5\u7269\u514d\u75ab\u539f\u6027\u5c0e\u81f4\u7684\u5931\u53bb\u61c9\u7b54\u554f\u984c\u3002\u8fd1\u5e74\u4f86\u91dd\u5c0dIL-12\u3001IL-23\u7b49\u9776\u9ede\u7684\u85e5\u7269\u5728\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u4e0a\u5c55\u73fe\u4e86\u512a\u52e2\uff0c\u4f46\u76ee\u524d\u6211\u570b\u4ecd\u6c92\u6709IL-23p19\u9776\u9ede\u85e5\u7269\u7372\u6279\u7528\u65bc\u6cbb\u7642\u6f70\u760d\u6027\u7d50\u8178\u708e\uff0c\u81e8\u5e8a\u4e0a\u4ecd\u5b58\u5728\u5de8\u5927\u7684\u9700\u6c42\u3002 \u95dc\u65bc\u5339\u5eb7\u5947\u62dc\u55ae\u6297\uff08IBI112\uff09 \u5339\u5eb7\u5947\u62dc\u55ae\u6297\uff08IBI112\uff09\u70ba\u91cd\u7d44\u6297\u767d\u4ecb\u7d2023p19\u4e9e\u57fa\uff08IL-23p19\uff09\u6297\u9ad4\u6ce8\u5c04\u6db2\uff0c\u662f\u7531\u4fe1\u9054\u751f\u7269\u81ea\u4e3b\u7814\u767c\uff0c\u5177\u6709\u81ea\u4e3b\u77e5\u8b58\u7522\u6b0a\u7684\u4e00\u7a2e\u55ae\u514b\u9686\u6297\u9ad4\uff0c\u7279\u7570\u6027\u7d50\u5408IL-23p19\u4e9e\u57fa\u3002\u901a\u904e\u963b\u6b62IL-23\u8207\u7d30\u80de\u8868\u9762\u53d7\u9ad4\u7d50\u5408\uff0c\u963b\u65b7IL-23\u53d7\u9ad4\u4ecb\u5c0e\u4fe1\u865f\u901a\u8def\u767c\u63ee\u6297\u708e\u4f5c\u7528\u3002IBI112\u6709\u671b\u70ba\u9280\u5c51\u75c5\u3001\u6f70\u760d\u6027\u8178\u708e\u548c\u5176\u4ed6\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u60a3\u8005\u63d0\u4f9b\u66f4\u6709\u6548\u3001\u66f4\u9577\u7d66\u85e5\u5468\u671f\u7684\u6cbb\u7642\u65b9\u6848\u3002 \u5339\u5eb7\u5947\u62dc\u55ae\u6297\u7576\u524d\u958b\u5c55\u4e86\u591a\u9805\u81e8\u5e8a\u7814\u7a76\uff0c\u5305\u62ec\uff1a \u5728\u4e2d\u91cd\u5ea6\u9280\u5c51\u75c5\u60a3\u8005\u4e2d\u958b\u5c55\u7684\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff08CLEAR-1\uff09\uff0c\u5df2\u65bc2024\u5e745\u6708\u9054\u6210\u7d42\u9ede\uff1b \u5728\u4e2d\u91cd\u5ea6\u9280\u5c51\u75c5\u60a3\u8005\u4e2d\u958b\u5c55\u7684\u96a8\u6a5f\u64a4\u85e5\u518d\u6cbb\u7642\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff1b \u5728\u4e2d\u91cd\u5ea6\u9280\u5c51\u75c5\u60a3\u8005\u4e2d\u958b\u5c55\u7684\u751f\u7269\u5236\u5291\u6cbb\u7642\u8f49\u5339\u5eb7\u5947\u62dc\u55ae\u6297\u6cbb\u7642\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\uff1b \u5728\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\u60a3\u8005\u4e2d\u958b\u5c55\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\u3002 2024\u5e749\u6708\uff0c\u5339\u5eb7\u5947\u62dc\u55ae\u6297\u7684\u9996\u500bNDA\u7372NMPA\u53d7\u7406\uff0c\u7528\u65bc\u6cbb\u7642\u4e2d\u91cd\u5ea6\u6591\u584a\u72c0\u9280\u5c51\u75c5\u3002 \u95dc\u65bc\u4fe1\u9054\u751f\u7269 \u300c\u59cb\u65bc\u4fe1\uff0c\u9054\u65bc\u884c\u300d\uff0c\u958b\u767c\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8cea\u91cf\u751f\u7269\u85e5\uff0c\u662f\u4fe1\u9054\u751f\u7269\u7684\u4f7f\u547d\u548c\u76ee\u6a19\u3002\u4fe1\u9054\u751f\u7269\u6210\u7acb\u65bc2011\u5e74\uff0c\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u7684\u5275\u65b0\u85e5\u7269\uff0c\u8b93\u6211\u5011\u7684\u5de5\u4f5c\u60e0\u53ca\u66f4\u591a\u7684\u751f\u547d\u3002\u516c\u53f8\u5df2\u670911\u500b\u7522\u54c1\u7372\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c\u5b83\u5011\u5206\u5225\u662f\u4fe1\u8fea\u5229\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u4f2f\u8212\u00ae\uff09\uff0c\u8c9d\u4f10\u73e0\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u6538\u540c\u00ae\uff09\uff0c\u963f\u9054\u6728\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u8607\u7acb\u4fe1\u00ae\uff09\uff0c\u5229\u59a5\u6614\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u4f2f\u83ef\u00ae\uff09\uff0c\u4f69\u7c73\u66ff\u5c3c\u7247\uff08\u9054\u4f2f\u5766\u00ae\uff09\uff0c\u5967\u96f7\u5df4\u66ff\u5c3c\u7247\uff08\u8010\u7acb\u514b\u00ae\uff09\uff0c\u96f7\u83ab\u897f\u5c24\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u5e0c\u5189\u64c7\u00ae\uff09\uff0c\u585e\u666e\u66ff\u5c3c\u81a0\u56ca\uff08\u777f\u59a5\u00ae\uff09\uff0c\u4f0a\u57fa\u5967\u4f96\u8cfd\u6ce8\u5c04\u6db2\uff08\u798f\u53ef\u8607\u00ae\uff09\uff0c\u6258\u840a\u897f\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u4fe1\u5fc5\u6a02\u00ae\uff09\u548c\u6c1f\u6fa4\u96f7\u585e\u7247\uff08\u9054\u4f2f\u7279\u00ae\uff09\u3002\u76ee\u524d\uff0c\u540c\u6642\u9084\u67095\u500b\u54c1\u7a2e\u5728NMPA\u5be9\u8a55\u4e2d\uff0c3\u500b\u65b0\u85e5\u5206\u5b50\u9032\u5165III\u671f\u6216\u95dc\u9375\u6027\u81e8\u5e8a\u7814\u7a76\uff0c\u53e6\u5916\u9084\u670917\u500b\u65b0\u85e5\u54c1\u7a2e\u5df2\u9032\u5165\u81e8\u5e8a\u7814\u7a76\u3002 \u516c\u53f8\u5df2\u8207\u79ae\u4f86\u3001\u7f85\u6c0f\u3001\u8cfd\u8afe\u83f2\u3001Adimab\u3001Incyte\u548cMD Anderson \u764c\u75c7\u4e2d\u5fc3\u7b49\u570b\u969b\u5408\u4f5c\u65b9\u9054\u621030\u591a\u9805\u6230\u7565\u5408\u4f5c\u3002\u4fe1\u9054\u751f\u7269\u5728\u4e0d\u65b7\u81ea\u7814\u5275\u65b0\u85e5\u7269\u3001\u8b00\u6c42\u81ea\u8eab\u767c\u5c55\u7684\u540c\u6642\uff0c\u79c9\u627f\u7d93\u6fdf\u5efa\u8a2d\u4ee5\u4eba\u6c11\u70ba\u4e2d\u5fc3\u7684\u767c\u5c55\u601d\u60f3\u3002\u591a\u5e74\u4f86\uff0c\u59cb\u7d42\u5fc3\u61f7\u79d1\u5b78\u5584\u5ff5\uff0c\u5805\u5b88\u300c\u4ee5\u60a3\u8005\u70ba\u4e2d\u5fc3\u300d\uff0c\u5fc3\u7cfb\u60a3\u8005\u4e26\u95dc\u6ce8\u60a3\u8005\u5bb6\u5ead\uff0c\u7a4d\u6975\u5c65\u884c\u793e\u6703\u8cac\u4efb\u3002\u516c\u53f8\u9678\u7e8c\u767c\u8d77\u3001\u53c3\u8207\u4e86\u591a\u9805\u85e5\u54c1\u516c\u76ca\u63f4\u52a9\u9805\u76ee\uff0c\u8b93\u8d8a\u4f86\u8d8a\u591a\u7684\u60a3\u8005\u80fd\u5920\u5f97\u76ca\u65bc\u751f\u547d\u79d1\u5b78\u7684\u9032\u6b65\uff0c\u8cb7\u5f97\u5230\u3001\u7528\u5f97\u8d77\u9ad8\u8cea\u91cf\u7684\u751f\u7269\u85e5\u3002\u622a\u81f3\u76ee\u524d\uff0c\u4fe1\u9054\u751f\u7269\u60a3\u8005\u63f4\u52a9\u9805\u76ee\u5df2\u60e0\u53ca17\u4f59\u842c\u666e\u901a\u60a3\u8005\uff0c\u85e5\u7269\u6350\u8d08\u7e3d\u50f9\u503c34\u5104\u5143\u4eba\u6c11\u5e63\u3002\u4fe1\u9054\u751f\u7269\u5e0c\u671b\u548c\u5927\u5bb6\u4e00\u8d77\u52aa\u529b\uff0c\u63d0\u9ad8\u4e2d\u570b\u751f\u7269\u5236\u85e5\u7522\u696d\u7684\u767c\u5c55\u6c34\u5e73\uff0c\u4ee5\u6eff\u8db3\u767e\u59d3\u7528\u85e5\u53ef\u53ca\u6027\u548c\u4eba\u6c11\u5c0d\u751f\u547d\u5065\u5eb7\u7f8e\u597d\u9858\u671b\u7684\u8ffd\u6c42\u3002 \u8a73\u60c5\u8acb\u8a2a\u554f\u516c\u53f8\u7db2\u7ad9\uff1awww.innoventbio.com\u6216\u516c\u53f8\u9818\u82f1\u8cec\u865f\u3002 \u8072\u660e\uff1a\u4fe1\u9054\u4e0d\u63a8\u85a6\u4efb\u4f55\u672a\u7372\u6279\u7684\u85e5\u54c1\/\u9069\u61c9\u75c7\u4f7f\u7528\u3002 \u524d\u77bb\u6027\u8072\u660e \u672c\u65b0\u805e\u7a3f\u6240\u767c\u5e03\u7684\u4fe1\u606f\u4e2d\u53ef\u80fd\u6703\u5305\u542b\u67d0\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u3002\u9019\u4e9b\u8868\u8ff0\u672c\u8cea\u4e0a\u5177\u6709\u76f8\u7576\u98a8\u96aa\u548c\u4e0d\u78ba\u5b9a\u6027\u3002\u5728\u4f7f\u7528\u300c\u9810\u671f\u300d\u3001\u300c\u76f8\u4fe1\u300d\u3001\u300c\u9810\u6e2c\u300d\u3001\u300c\u671f\u671b\u300d\u3001\u300c\u6253\u7b97\u300d\u53ca\u5176\u4ed6\u985e\u4f3c\u8a5e\u8a9e\u9032\u884c\u8868\u8ff0\u6642\uff0c\u51e1\u8207\u672c\u516c\u53f8\u6709\u95dc\u7684\uff0c\u76ee\u7684\u5747\u662f\u8981\u6307\u660e\u5176\u5c6c\u524d\u77bb\u6027\u8868\u8ff0\u3002\u672c\u516c\u53f8\u4e26\u7121\u7fa9\u52d9\u4e0d\u65b7\u5730\u66f4\u65b0\u9019\u4e9b\u9810\u6e2c\u6027\u9673\u8ff0\u3002 \u9019\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u4e43\u57fa\u65bc\u672c\u516c\u53f8\u7ba1\u7406\u5c64\u5728\u505a\u51fa\u8868\u8ff0\u6642\u5c0d\u672a\u4f86\u4e8b\u52d9\u7684\u73fe\u6709\u770b\u6cd5\u3001\u5047\u8a2d\u3001\u671f\u671b\u3001\u4f30\u8a08\u3001\u9810\u6e2c\u548c\u7406\u89e3\u3002\u9019\u4e9b\u8868\u8ff0\u4e26\u975e\u5c0d\u672a\u4f86\u767c\u5c55\u7684\u4fdd\u8b49\uff0c\u6703\u53d7\u5230\u98a8\u96aa\u3001\u4e0d\u78ba\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u97ff\uff0c\u6709\u4e9b\u4e43\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u8303\u570d\uff0c\u96e3\u4ee5\u9810\u8a08\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u5011\u7684\u696d\u52d9\u3001\u7af6\u722d\u74b0\u5883\u3001\u653f\u6cbb\u3001\u7d93\u6fdf\u3001\u6cd5\u5f8b\u548c\u793e\u6703\u60c5\u6cc1\u7684\u672a\u4f86\u8b8a\u5316\u53ca\u767c\u5c55\u7684\u5f71\u97ff\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u6703\u8207\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8cc7\u6599\u6709\u8f03\u5927\u5dee\u5225\u3002\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.franchise.com.hk\/en\/%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%8c%b9%e5%ba%b7%e5%a5%87%e6%8b%9c%e5%96%ae%e6%8a%97%ef%bc%88il-23p19%e6%8a%97%e9%ab%94%ef%bc%89%e6%b2%bb%e7%99%82%e6%bd%b0%e7%98%8d%e6%80%a7\/22482\" \/>\n<meta property=\"og:site_name\" content=\"\u9999\u6e2f\u7279\u8a31\u7d93\u71df\" \/>\n<meta property=\"article:published_time\" content=\"2024-10-16T16:00:00+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.franchise.com.hk\/en\/%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%8c%b9%e5%ba%b7%e5%a5%87%e6%8b%9c%e5%96%ae%e6%8a%97%ef%bc%88il-23p19%e6%8a%97%e9%ab%94%ef%bc%89%e6%b2%bb%e7%99%82%e6%bd%b0%e7%98%8d%e6%80%a7\/22482#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.franchise.com.hk\/en\/%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%8c%b9%e5%ba%b7%e5%a5%87%e6%8b%9c%e5%96%ae%e6%8a%97%ef%bc%88il-23p19%e6%8a%97%e9%ab%94%ef%bc%89%e6%b2%bb%e7%99%82%e6%bd%b0%e7%98%8d%e6%80%a7\/22482\"},\"author\":{\"name\":\"\",\"@id\":\"\"},\"headline\":\"\u4fe1\u9054\u751f\u7269\u5ba3\u5e03\u5339\u5eb7\u5947\u62dc\u55ae\u6297\uff08IL-23p19\u6297\u9ad4\uff09\u6cbb\u7642\u6f70\u760d\u6027\u7d50\u8178\u708e\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\u9054\u6210\u4e3b\u8981\u7d42\u9ede\",\"datePublished\":\"2024-10-16T16:00:00+00:00\",\"dateModified\":\"2024-10-16T16:00:00+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.franchise.com.hk\/en\/%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%8c%b9%e5%ba%b7%e5%a5%87%e6%8b%9c%e5%96%ae%e6%8a%97%ef%bc%88il-23p19%e6%8a%97%e9%ab%94%ef%bc%89%e6%b2%bb%e7%99%82%e6%bd%b0%e7%98%8d%e6%80%a7\/22482\"},\"wordCount\":67,\"publisher\":{\"@id\":\"https:\/\/www.franchise.com.hk\/en#organization\"},\"articleSection\":[\"\u672a\u5206\u985e\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.franchise.com.hk\/en\/%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%8c%b9%e5%ba%b7%e5%a5%87%e6%8b%9c%e5%96%ae%e6%8a%97%ef%bc%88il-23p19%e6%8a%97%e9%ab%94%ef%bc%89%e6%b2%bb%e7%99%82%e6%bd%b0%e7%98%8d%e6%80%a7\/22482\",\"url\":\"https:\/\/www.franchise.com.hk\/en\/%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%8c%b9%e5%ba%b7%e5%a5%87%e6%8b%9c%e5%96%ae%e6%8a%97%ef%bc%88il-23p19%e6%8a%97%e9%ab%94%ef%bc%89%e6%b2%bb%e7%99%82%e6%bd%b0%e7%98%8d%e6%80%a7\/22482\",\"name\":\"\u4fe1\u9054\u751f\u7269\u5ba3\u5e03\u5339\u5eb7\u5947\u62dc\u55ae\u6297\uff08IL-23p19\u6297\u9ad4\uff09\u6cbb\u7642\u6f70\u760d\u6027\u7d50\u8178\u708e\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\u9054\u6210\u4e3b\u8981\u7d42\u9ede - \u9999\u6e2f\u7279\u8a31\u7d93\u71df\",\"isPartOf\":{\"@id\":\"https:\/\/www.franchise.com.hk\/en#website\"},\"datePublished\":\"2024-10-16T16:00:00+00:00\",\"dateModified\":\"2024-10-16T16:00:00+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.franchise.com.hk\/en\/%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%8c%b9%e5%ba%b7%e5%a5%87%e6%8b%9c%e5%96%ae%e6%8a%97%ef%bc%88il-23p19%e6%8a%97%e9%ab%94%ef%bc%89%e6%b2%bb%e7%99%82%e6%bd%b0%e7%98%8d%e6%80%a7\/22482#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.franchise.com.hk\/en\/%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%8c%b9%e5%ba%b7%e5%a5%87%e6%8b%9c%e5%96%ae%e6%8a%97%ef%bc%88il-23p19%e6%8a%97%e9%ab%94%ef%bc%89%e6%b2%bb%e7%99%82%e6%bd%b0%e7%98%8d%e6%80%a7\/22482\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.franchise.com.hk\/en\/%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%8c%b9%e5%ba%b7%e5%a5%87%e6%8b%9c%e5%96%ae%e6%8a%97%ef%bc%88il-23p19%e6%8a%97%e9%ab%94%ef%bc%89%e6%b2%bb%e7%99%82%e6%bd%b0%e7%98%8d%e6%80%a7\/22482#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9801\",\"item\":\"https:\/\/www.franchise.com.hk\/en\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u4fe1\u9054\u751f\u7269\u5ba3\u5e03\u5339\u5eb7\u5947\u62dc\u55ae\u6297\uff08IL-23p19\u6297\u9ad4\uff09\u6cbb\u7642\u6f70\u760d\u6027\u7d50\u8178\u708e\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\u9054\u6210\u4e3b\u8981\u7d42\u9ede\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.franchise.com.hk\/en#website\",\"url\":\"https:\/\/www.franchise.com.hk\/en\",\"name\":\"\u9999\u6e2f\u7279\u8a31\u7d93\u71df\",\"description\":\"\u9999\u6e2f\u7279\u8a31\u7d93\u71df | Franchise HK\",\"publisher\":{\"@id\":\"https:\/\/www.franchise.com.hk\/en#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.franchise.com.hk\/en?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.franchise.com.hk\/en#organization\",\"name\":\"\u9999\u6e2f\u7279\u8a31\u7d93\u71df\",\"url\":\"https:\/\/www.franchise.com.hk\/en\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.franchise.com.hk\/en#\/schema\/logo\/image\/\",\"url\":\"https:\/\/i0.wp.com\/www.franchise.com.hk\/wp-content\/uploads\/2022\/05\/cropped-cropped-franchise-logo-02-e1652686851566-2.png?fit=350%2C76&ssl=1\",\"contentUrl\":\"https:\/\/i0.wp.com\/www.franchise.com.hk\/wp-content\/uploads\/2022\/05\/cropped-cropped-franchise-logo-02-e1652686851566-2.png?fit=350%2C76&ssl=1\",\"width\":350,\"height\":76,\"caption\":\"\u9999\u6e2f\u7279\u8a31\u7d93\u71df\"},\"image\":{\"@id\":\"https:\/\/www.franchise.com.hk\/en#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u4fe1\u9054\u751f\u7269\u5ba3\u5e03\u5339\u5eb7\u5947\u62dc\u55ae\u6297\uff08IL-23p19\u6297\u9ad4\uff09\u6cbb\u7642\u6f70\u760d\u6027\u7d50\u8178\u708e\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\u9054\u6210\u4e3b\u8981\u7d42\u9ede - \u9999\u6e2f\u7279\u8a31\u7d93\u71df","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.franchise.com.hk\/en\/%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%8c%b9%e5%ba%b7%e5%a5%87%e6%8b%9c%e5%96%ae%e6%8a%97%ef%bc%88il-23p19%e6%8a%97%e9%ab%94%ef%bc%89%e6%b2%bb%e7%99%82%e6%bd%b0%e7%98%8d%e6%80%a7\/22482","og_locale":"en_US","og_type":"article","og_title":"\u4fe1\u9054\u751f\u7269\u5ba3\u5e03\u5339\u5eb7\u5947\u62dc\u55ae\u6297\uff08IL-23p19\u6297\u9ad4\uff09\u6cbb\u7642\u6f70\u760d\u6027\u7d50\u8178\u708e\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\u9054\u6210\u4e3b\u8981\u7d42\u9ede - \u9999\u6e2f\u7279\u8a31\u7d93\u71df","og_description":"\u7f8e\u570b\u820a\u91d1\u5c71\u548c\u4e2d\u570b\u8607\u5dde2024\u5e7410\u670817\u65e5 \/\u7f8e\u901a\u793e\/ — \u4fe1\u9054\u751f\u7269\u5236\u85e5\u96c6\u5718\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u80a1\u7968\u4ee3\u78bc\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u53ca\u5fc3\u8840\u7ba1\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u5275\u65b0\u85e5\u7269\u7684\u751f\u7269\u5236\u85e5\u516c\u53f8\u5ba3\u5e03\uff1a\u5339\u5eb7\u5947\u62dc\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u91cd\u7d44\u6297\u767d\u4ecb\u7d2023p19\u4e9e\u57fa\uff08IL-23p19\uff09\u6297\u9ad4\uff0c\u7814\u767c\u4ee3\u865f\uff1aIBI112\uff09\u5728\u4e2d\u570b\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\uff08UC\uff09\u53d7\u8a66\u8005\u4e2d\u958b\u5c55\u7684\u4e00\u9805\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\uff08Clinicaltrials.gov, NCT05377580\uff09\u4e2d\u9054\u6210\u4e3b\u8981\u7d42\u9ede\u3002 \u8a72\u7814\u7a76\u65e8\u5728\u8a55\u50f9\u5339\u5eb7\u5947\u62dc\u55ae\u6297\u8a98\u5c0e\u6cbb\u7642\u548c\u7dad\u6301\u6cbb\u7642\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\uff08\u5165\u9078\u6a19\u51c6\u70ba\u6539\u826fMayo\u8a55\u52064\uff5e9\u5206\uff0c\u4e14\u5176\u4e2d\u5167\u93e1\u8a55\u5206\u22652\u5206\uff09\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u7814\u7a76\u5171\u5165\u7d44150\u4f8b\u53d7\u8a66\u8005\uff0c\u63091:1:1\u7684\u6bd4\u4f8b\u96a8\u6a5f\u63a5\u53d7\u5b89\u6170\u5291\u3001\u5339\u5eb7\u5947\u62dc\u55ae\u6297200 mg\u6216\u5339\u5eb7\u5947\u62dc\u55ae\u6297600 mg\u7b2c0\u30014\u30018\u5468\u975c\u8108\u8f38\u6ce8\u6cbb\u7642\uff0c\u8a98\u5c0e\u6cbb\u7642\u5f8c\u91c7\u7528200 mg\u5339\u5eb7\u5947\u62dc\u55ae\u6297\u6bcf4\u5468\u6216\u6bcf8\u5468\u76ae\u4e0b\u6ce8\u5c04\u9032\u884c\u7dad\u6301\u6cbb\u7642\u3002\u7814\u7a76\u4e3b\u8981\u7d42\u9ede\u70ba\u8a98\u5c0e\u6cbb\u7642\u671f\u7b2c12\u5468\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\uff08\u5b9a\u7fa9\u70ba\u6539\u826fMayo\u8a55\u5206\u7684\u4fbf\u8840\u70ba0\u5206\uff0c\u6392\u4fbf\u6b21\u6578\u22641\u5206\u4ee5\u53ca\u5167\u93e1\u767c\u73fe\u22641\u5206\uff09\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u3002\u6b21\u8981\u7d42\u9ede\u5305\u62ec\u8a98\u5c0e\u6cbb\u7642\u671f\u7b2c12\u5468\u9054\u5230\u81e8\u5e8a\u61c9\u7b54\u3001\u75c7\u72c0\u7de9\u89e3\u3001\u5167\u93e1\u7de9\u89e3\u6216\u9ecf\u819c\u6108\u5408\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u7b49\u3002 \u7814\u7a76\u9054\u6210\u4e3b\u8981\u7d42\u9ede\u548c\u6b21\u8981\u7d42\u9ede\uff0c\u5373\uff1a \u8a98\u5c0e\u6cbb\u7642\u671f\u7b2c12\u5468\u6642\uff0c\u5339\u5eb7\u5947\u62dc\u55ae\u6297200 mg\u7d44\u548c600 mg\u7d44\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u5206\u5225\u662f20.0%\u548c14.0%\uff0c\u5747\u986f\u8457\u9ad8\u65bc\u5b89\u6170\u5291\u7d44\uff082.0%\uff1bp <0.05\uff09\u3002 \u5339\u5eb7\u5947\u62dc\u55ae\u6297200 mg\u7d44\u548c600 mg\u7d44\u9054\u5230\u81e8\u5e8a\u61c9\u7b54\u7684\u53d7\u8a66\u8005\u5206\u5225\u70ba54.0%\u548c68.0%\uff0c\u5747\u986f\u8457\u9ad8\u65bc\u5b89\u6170\u5291\u7d44\uff0822.0%\uff1bp <0.001\uff09\u3002 \u6b64\u5916\uff0c\u5339\u5eb7\u5947\u62dc\u55ae\u6297200 mg\u7d44\u548c600 mg\u7d44\u9054\u5230\u75c7\u72c0\u7de9\u89e3\u3001\u5167\u93e1\u7de9\u89e3\u6216\u9ecf\u819c\u6108\u5408\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u5747\u9ad8\u65bc\u5b89\u6170\u5291\u7d44\u3002 \u5b89\u5168\u6027\u65b9\u9762\uff0c\u5339\u5eb7\u5947\u62dc\u55ae\u6297\u7d44\u7e3d\u9ad4\u5b89\u5168\u6027\u826f\u597d\uff0c\u672a\u767c\u73fe\u65b0\u589e\u5b89\u5168\u6027\u4fe1\u865f\uff0c\u8207\u65e2\u5f80\u7814\u7a76\u548c\u540c\u985e\u7522\u54c1\u7684\u5b89\u5168\u6027\u7279\u5f81\u76f8\u4f3c\u3002 \u622a\u81f3\u76ee\u524d\u7814\u7a76\u7dad\u6301\u671f\u4ecd\u5728\u9032\u884c\u4e2d\uff0c\u9032\u5165\u7dad\u6301\u671f\u7684\u53d7\u8a66\u8005\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\u3001\u81e8\u5e8a\u61c9\u7b54\u3001\u75c7\u72c0\u7de9\u89e3\u3001\u5167\u93e1\u7de9\u89e3\u6216\u9ecf\u819c\u6108\u5408\u7684\u6bd4\u4f8b\u76f8\u8f03\u8a98\u5c0e\u671f\u5747\u6709\u4e0d\u540c\u7a0b\u5ea6\u7684\u7e7c\u7e8c\u63d0\u5347\u3002\u5b8c\u6574\u6578\u64da\u8a08\u5283\u5728\u672a\u4f86\u5b78\u8853\u5927\u6703\u6216\u671f\u520a\u6295\u7a3f\u767c\u8868\u3002 \u8a72\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u4e2d\u5c71\u5927\u5b78\u9644\u5c6c\u7b2c\u4e00\u91ab\u9662\u9673\u65fb\u6e56\u6559\u6388\u8868\u793a\uff1a\u300c\u6f70\u760d\u6027\u7d50\u8178\u708e\u662f\u4e00\u7a2e\u6162\u6027\u3001\u5fa9\u767c\u6027\u7684\u7d50\u76f4\u8178\u9ecf\u819c\u708e\u75c7\u75be\u75c5\uff0c\u8207\u907a\u50b3\u3001\u74b0\u5883\u548c\u514d\u75ab\u7cfb\u7d71\u56e0\u7d20\u76f8\u4e92\u4f5c\u7528\u6709\u95dc\u3002\u5e38\u898b\u75c7\u72c0\u5305\u62ec\u8179\u75db\u3001\u8179\u7009\u3001\u4fbf\u8840\u3001\u9ad4\u91cd\u6e1b\u8f15\u548c\u75b2\u52de\u7b49\u3002\u73fe\u6709\u6cbb\u7642\u624b\u6bb5\u4e3b\u8981\u96c6\u4e2d\u5728\u63a7\u5236\u708e\u75c7\u3001\u7de9\u89e3\u75c7\u72c0\u548c\u7dad\u6301\u7de9\u89e3\u3002\u76e1\u7ba1\u6cbb\u7642\u65b9\u6cd5\u4e0d\u65b7\u9032\u6b65\uff0c\u4f46\u4ecd\u9762\u81e8\u8af8\u591a\u6311\u6230\uff0c\u4e9f\u5f85\u65b0\u7684\u6cbb\u7642\u624b\u6bb5\u3002\u6211\u5f88\u9ad8\u8208\u770b\u5230\u5339\u5eb7\u5947\u62dc\u55ae\u6297\u6cbb\u7642\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178II\u671f\u81e8\u5e8a\u7814\u7a76\u4e2d\u9054\u6210\u4e3b\u8981\u7d42\u9ede\uff0c\u53d7\u8a66\u8005\u7372\u5f97\u986f\u8457\u7684\u8a98\u5c0e\u671f\u81e8\u5e8a\u7372\u76ca\uff0c\u540c\u6642\u5b89\u5168\u6027\u826f\u597d\u3002\u6211\u671f\u5f85\u672a\u4f86\u7522\u54c1\u9806\u5229\u958b\u767c\uff0c\u70ba\u4e2d\u570b\u6f70\u760d\u6027\u7d50\u8178\u708e\u60a3\u8005\u63d0\u4f9b\u66f4\u591a\u7684\u6cbb\u7642\u9078\u64c7\u3002\u300d \u4fe1\u9054\u751f\u7269\u5236\u85e5\u96c6\u5718\u81e8\u5e8a\u9ad8\u7d1a\u526f\u7e3d\u88c1\u9322\u9433\u535a\u58eb\u8868\u793a\uff1a\u300c\u6f70\u760d\u6027\u7d50\u8178\u708e\u4f5c\u70ba\u4e00\u7a2e\u6162\u6027\u708e\u75c7\u6027\u75be\u75c5\uff0c\u9664\u537b\u5c0d\u8eab\u9ad4\u5065\u5eb7\u7684\u640d\u5bb3\uff0c\u5176\u5c0d\u60a3\u8005\u7684\u65e5\u5e38\u751f\u6d3b\u4e5f\u6709\u56b4\u91cd\u5e72\u64fe\uff0c\u5c0d\u60a3\u8005\u7684\u5fc3\u7406\u7522\u751f\u5de8\u5927\u7684\u8ca0\u9762\u5f71\u97ff\u3002\u8fd1\u5e74\u4f86\uff0c\u4ee5IL-23\u70ba\u9776\u9ede\u7684\u65b0\u4e00\u4ee3\u85e5\u7269\u56e0\u5176\u5728\u6f70\u760d\u6027\u7d50\u8178\u708e\u60a3\u8005\u6cbb\u7642\u4e2d\u5353\u8d8a\u7684\u7642\u6548\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u5f15\u767c\u95dc\u6ce8\uff1b\u76ee\u524d\uff0c\u570b\u5167\u5e02\u5834\u4e0a\u5c1a\u7121IL-23p19\u9776\u9ede\u85e5\u7269\u7372\u6279\u6cbb\u7642\u6f70\u760d\u6027\u7d50\u8178\u708e\uff0c\u672c\u7814\u7a76\u662f\u7b2c\u4e00\u500b\u7531\u570b\u5167\u4f01\u696d\u81ea\u4e3b\u7814\u767c\u7684IL-23p19\u55ae\u6297\u6cbb\u7642\u6f70\u760d\u6027\u7d50\u8178\u708e\u7684\u81e8\u5e8a\u7814\u7a76\u3002\u4fe1\u9054\u751f\u7269\u81ea\u4e3b\u7814\u767c\u7684\u5339\u5eb7\u5947\u62dc\u55ae\u6297\u5df2\u7d93\u5728\u6591\u584a\u72c0\u9280\u5c51\u75c5\u53d6\u5f97\u6210\u529f\uff0c\u672c\u6b21\u5728\u6f70\u760d\u6027\u7d50\u8178\u708eII\u671f\u81e8\u5e8a\u7814\u7a76\u4e2d\u7684\u7d50\u679c\u512a\u7570\uff0c\u8a98\u5c0e\u671f\u7642\u6548\u3001\u7dad\u6301\u671f\u7684\u521d\u6b65\u7642\u6548\u53ca\u5176\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u4f7f\u6211\u5011\u66f4\u6df1\u53d7\u9f13\u821e\uff0c\u6211\u5011\u671f\u5f85\u4fe1\u9054\u751f\u7269\u66f4\u591a\u53ef\u53ca\u6027\u826f\u597d\u4e14\u9ad8\u8cea\u91cf\u7684\u5275\u65b0\u751f\u7269\u85e5\u53ef\u4ee5\u65e9\u65e5\u60e0\u53ca\u5ee3\u5927\u60a3\u8005\u3002\u300d \u95dc\u65bc\u6f70\u760d\u6027\u7d50\u8178\u708e \u6f70\u760d\u6027\u7d50\u8178\u708e\u70ba\u4e00\u7a2e\u6162\u6027\u975e\u7279\u7570\u6027\u8178\u9053\u708e\u75c7\u6027\u75be\u75c5\uff08IBD\uff09\uff0c\u4ee5\u7d50\u8178\u548c\u76f4\u8178\u708e\u75c7\u70ba\u7279\u5f81\u3002\u5178\u578b\u75c7\u72c0\u70ba\u53cd\u5fa9\u767c\u4f5c\u7684\u8179\u7009\u3001\u7c98\u6db2\u81bf\u8840\u4fbf\u4f34\u8179\u75db\u3001\u88e1\u6025\u5f8c\u91cd\u3002\u6f70\u760d\u6027\u7d50\u8178\u708e\u56b4\u91cd\u5a01\u8105\u8eab\u9ad4\u5065\u5eb7\u4e26\u5c0d\u65e5\u5e38\u751f\u6d3b\u548c\u5fc3\u7406\u5e36\u4f86\u5f71\u97ff\u3002\u6f70\u760d\u6027\u7d50\u8178\u708e\u597d\u767c\u65bc\u4e2d\u9752\u5e74\uff0c\u5728\u4e2d\u570b\uff0c\u8fd120\u5e74\u4f86\u5c31\u8a3a\u4eba\u6578\u5448\u5feb\u901f\u4e0a\u5347\u8da8\u52e2\uff0c\u60a3\u75c5\u7387\u70ba11.6\/10\u842c\u3002\u6f70\u760d\u6027\u7d50\u8178\u708e\u7684\u81e8\u5e8a\u6cbb\u7642\u624b\u6bb5\u4ee5\u85e5\u7269\u548c\u624b\u8853\u6cbb\u7642\u70ba\u4e3b\uff0c\u786b\u560c\u5464\u85e5\u7269\u70ba\u6700\u50b3\u7d71\u7684\u6cbb\u7642\u514d\u75ab\u6291\u5236\u5291\uff0c\u4f46\u4e0d\u826f\u53cd\u61c9\u767c\u751f\u7387\u9ad8\u3002\u751f\u7269\u5236\u5291\u65b9\u9762\uff0c\u6297TNF-\u03b1\u6cbb\u7642\u5b58\u5728\u85e5\u7269\u514d\u75ab\u539f\u6027\u5c0e\u81f4\u7684\u5931\u53bb\u61c9\u7b54\u554f\u984c\u3002\u8fd1\u5e74\u4f86\u91dd\u5c0dIL-12\u3001IL-23\u7b49\u9776\u9ede\u7684\u85e5\u7269\u5728\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u4e0a\u5c55\u73fe\u4e86\u512a\u52e2\uff0c\u4f46\u76ee\u524d\u6211\u570b\u4ecd\u6c92\u6709IL-23p19\u9776\u9ede\u85e5\u7269\u7372\u6279\u7528\u65bc\u6cbb\u7642\u6f70\u760d\u6027\u7d50\u8178\u708e\uff0c\u81e8\u5e8a\u4e0a\u4ecd\u5b58\u5728\u5de8\u5927\u7684\u9700\u6c42\u3002 \u95dc\u65bc\u5339\u5eb7\u5947\u62dc\u55ae\u6297\uff08IBI112\uff09 \u5339\u5eb7\u5947\u62dc\u55ae\u6297\uff08IBI112\uff09\u70ba\u91cd\u7d44\u6297\u767d\u4ecb\u7d2023p19\u4e9e\u57fa\uff08IL-23p19\uff09\u6297\u9ad4\u6ce8\u5c04\u6db2\uff0c\u662f\u7531\u4fe1\u9054\u751f\u7269\u81ea\u4e3b\u7814\u767c\uff0c\u5177\u6709\u81ea\u4e3b\u77e5\u8b58\u7522\u6b0a\u7684\u4e00\u7a2e\u55ae\u514b\u9686\u6297\u9ad4\uff0c\u7279\u7570\u6027\u7d50\u5408IL-23p19\u4e9e\u57fa\u3002\u901a\u904e\u963b\u6b62IL-23\u8207\u7d30\u80de\u8868\u9762\u53d7\u9ad4\u7d50\u5408\uff0c\u963b\u65b7IL-23\u53d7\u9ad4\u4ecb\u5c0e\u4fe1\u865f\u901a\u8def\u767c\u63ee\u6297\u708e\u4f5c\u7528\u3002IBI112\u6709\u671b\u70ba\u9280\u5c51\u75c5\u3001\u6f70\u760d\u6027\u8178\u708e\u548c\u5176\u4ed6\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u60a3\u8005\u63d0\u4f9b\u66f4\u6709\u6548\u3001\u66f4\u9577\u7d66\u85e5\u5468\u671f\u7684\u6cbb\u7642\u65b9\u6848\u3002 \u5339\u5eb7\u5947\u62dc\u55ae\u6297\u7576\u524d\u958b\u5c55\u4e86\u591a\u9805\u81e8\u5e8a\u7814\u7a76\uff0c\u5305\u62ec\uff1a \u5728\u4e2d\u91cd\u5ea6\u9280\u5c51\u75c5\u60a3\u8005\u4e2d\u958b\u5c55\u7684\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff08CLEAR-1\uff09\uff0c\u5df2\u65bc2024\u5e745\u6708\u9054\u6210\u7d42\u9ede\uff1b \u5728\u4e2d\u91cd\u5ea6\u9280\u5c51\u75c5\u60a3\u8005\u4e2d\u958b\u5c55\u7684\u96a8\u6a5f\u64a4\u85e5\u518d\u6cbb\u7642\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff1b \u5728\u4e2d\u91cd\u5ea6\u9280\u5c51\u75c5\u60a3\u8005\u4e2d\u958b\u5c55\u7684\u751f\u7269\u5236\u5291\u6cbb\u7642\u8f49\u5339\u5eb7\u5947\u62dc\u55ae\u6297\u6cbb\u7642\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\uff1b \u5728\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\u60a3\u8005\u4e2d\u958b\u5c55\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\u3002 2024\u5e749\u6708\uff0c\u5339\u5eb7\u5947\u62dc\u55ae\u6297\u7684\u9996\u500bNDA\u7372NMPA\u53d7\u7406\uff0c\u7528\u65bc\u6cbb\u7642\u4e2d\u91cd\u5ea6\u6591\u584a\u72c0\u9280\u5c51\u75c5\u3002 \u95dc\u65bc\u4fe1\u9054\u751f\u7269 \u300c\u59cb\u65bc\u4fe1\uff0c\u9054\u65bc\u884c\u300d\uff0c\u958b\u767c\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8cea\u91cf\u751f\u7269\u85e5\uff0c\u662f\u4fe1\u9054\u751f\u7269\u7684\u4f7f\u547d\u548c\u76ee\u6a19\u3002\u4fe1\u9054\u751f\u7269\u6210\u7acb\u65bc2011\u5e74\uff0c\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u7684\u5275\u65b0\u85e5\u7269\uff0c\u8b93\u6211\u5011\u7684\u5de5\u4f5c\u60e0\u53ca\u66f4\u591a\u7684\u751f\u547d\u3002\u516c\u53f8\u5df2\u670911\u500b\u7522\u54c1\u7372\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c\u5b83\u5011\u5206\u5225\u662f\u4fe1\u8fea\u5229\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u4f2f\u8212\u00ae\uff09\uff0c\u8c9d\u4f10\u73e0\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u6538\u540c\u00ae\uff09\uff0c\u963f\u9054\u6728\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u8607\u7acb\u4fe1\u00ae\uff09\uff0c\u5229\u59a5\u6614\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u4f2f\u83ef\u00ae\uff09\uff0c\u4f69\u7c73\u66ff\u5c3c\u7247\uff08\u9054\u4f2f\u5766\u00ae\uff09\uff0c\u5967\u96f7\u5df4\u66ff\u5c3c\u7247\uff08\u8010\u7acb\u514b\u00ae\uff09\uff0c\u96f7\u83ab\u897f\u5c24\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u5e0c\u5189\u64c7\u00ae\uff09\uff0c\u585e\u666e\u66ff\u5c3c\u81a0\u56ca\uff08\u777f\u59a5\u00ae\uff09\uff0c\u4f0a\u57fa\u5967\u4f96\u8cfd\u6ce8\u5c04\u6db2\uff08\u798f\u53ef\u8607\u00ae\uff09\uff0c\u6258\u840a\u897f\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u4fe1\u5fc5\u6a02\u00ae\uff09\u548c\u6c1f\u6fa4\u96f7\u585e\u7247\uff08\u9054\u4f2f\u7279\u00ae\uff09\u3002\u76ee\u524d\uff0c\u540c\u6642\u9084\u67095\u500b\u54c1\u7a2e\u5728NMPA\u5be9\u8a55\u4e2d\uff0c3\u500b\u65b0\u85e5\u5206\u5b50\u9032\u5165III\u671f\u6216\u95dc\u9375\u6027\u81e8\u5e8a\u7814\u7a76\uff0c\u53e6\u5916\u9084\u670917\u500b\u65b0\u85e5\u54c1\u7a2e\u5df2\u9032\u5165\u81e8\u5e8a\u7814\u7a76\u3002 \u516c\u53f8\u5df2\u8207\u79ae\u4f86\u3001\u7f85\u6c0f\u3001\u8cfd\u8afe\u83f2\u3001Adimab\u3001Incyte\u548cMD Anderson \u764c\u75c7\u4e2d\u5fc3\u7b49\u570b\u969b\u5408\u4f5c\u65b9\u9054\u621030\u591a\u9805\u6230\u7565\u5408\u4f5c\u3002\u4fe1\u9054\u751f\u7269\u5728\u4e0d\u65b7\u81ea\u7814\u5275\u65b0\u85e5\u7269\u3001\u8b00\u6c42\u81ea\u8eab\u767c\u5c55\u7684\u540c\u6642\uff0c\u79c9\u627f\u7d93\u6fdf\u5efa\u8a2d\u4ee5\u4eba\u6c11\u70ba\u4e2d\u5fc3\u7684\u767c\u5c55\u601d\u60f3\u3002\u591a\u5e74\u4f86\uff0c\u59cb\u7d42\u5fc3\u61f7\u79d1\u5b78\u5584\u5ff5\uff0c\u5805\u5b88\u300c\u4ee5\u60a3\u8005\u70ba\u4e2d\u5fc3\u300d\uff0c\u5fc3\u7cfb\u60a3\u8005\u4e26\u95dc\u6ce8\u60a3\u8005\u5bb6\u5ead\uff0c\u7a4d\u6975\u5c65\u884c\u793e\u6703\u8cac\u4efb\u3002\u516c\u53f8\u9678\u7e8c\u767c\u8d77\u3001\u53c3\u8207\u4e86\u591a\u9805\u85e5\u54c1\u516c\u76ca\u63f4\u52a9\u9805\u76ee\uff0c\u8b93\u8d8a\u4f86\u8d8a\u591a\u7684\u60a3\u8005\u80fd\u5920\u5f97\u76ca\u65bc\u751f\u547d\u79d1\u5b78\u7684\u9032\u6b65\uff0c\u8cb7\u5f97\u5230\u3001\u7528\u5f97\u8d77\u9ad8\u8cea\u91cf\u7684\u751f\u7269\u85e5\u3002\u622a\u81f3\u76ee\u524d\uff0c\u4fe1\u9054\u751f\u7269\u60a3\u8005\u63f4\u52a9\u9805\u76ee\u5df2\u60e0\u53ca17\u4f59\u842c\u666e\u901a\u60a3\u8005\uff0c\u85e5\u7269\u6350\u8d08\u7e3d\u50f9\u503c34\u5104\u5143\u4eba\u6c11\u5e63\u3002\u4fe1\u9054\u751f\u7269\u5e0c\u671b\u548c\u5927\u5bb6\u4e00\u8d77\u52aa\u529b\uff0c\u63d0\u9ad8\u4e2d\u570b\u751f\u7269\u5236\u85e5\u7522\u696d\u7684\u767c\u5c55\u6c34\u5e73\uff0c\u4ee5\u6eff\u8db3\u767e\u59d3\u7528\u85e5\u53ef\u53ca\u6027\u548c\u4eba\u6c11\u5c0d\u751f\u547d\u5065\u5eb7\u7f8e\u597d\u9858\u671b\u7684\u8ffd\u6c42\u3002 \u8a73\u60c5\u8acb\u8a2a\u554f\u516c\u53f8\u7db2\u7ad9\uff1awww.innoventbio.com\u6216\u516c\u53f8\u9818\u82f1\u8cec\u865f\u3002 \u8072\u660e\uff1a\u4fe1\u9054\u4e0d\u63a8\u85a6\u4efb\u4f55\u672a\u7372\u6279\u7684\u85e5\u54c1\/\u9069\u61c9\u75c7\u4f7f\u7528\u3002 \u524d\u77bb\u6027\u8072\u660e \u672c\u65b0\u805e\u7a3f\u6240\u767c\u5e03\u7684\u4fe1\u606f\u4e2d\u53ef\u80fd\u6703\u5305\u542b\u67d0\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u3002\u9019\u4e9b\u8868\u8ff0\u672c\u8cea\u4e0a\u5177\u6709\u76f8\u7576\u98a8\u96aa\u548c\u4e0d\u78ba\u5b9a\u6027\u3002\u5728\u4f7f\u7528\u300c\u9810\u671f\u300d\u3001\u300c\u76f8\u4fe1\u300d\u3001\u300c\u9810\u6e2c\u300d\u3001\u300c\u671f\u671b\u300d\u3001\u300c\u6253\u7b97\u300d\u53ca\u5176\u4ed6\u985e\u4f3c\u8a5e\u8a9e\u9032\u884c\u8868\u8ff0\u6642\uff0c\u51e1\u8207\u672c\u516c\u53f8\u6709\u95dc\u7684\uff0c\u76ee\u7684\u5747\u662f\u8981\u6307\u660e\u5176\u5c6c\u524d\u77bb\u6027\u8868\u8ff0\u3002\u672c\u516c\u53f8\u4e26\u7121\u7fa9\u52d9\u4e0d\u65b7\u5730\u66f4\u65b0\u9019\u4e9b\u9810\u6e2c\u6027\u9673\u8ff0\u3002 \u9019\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u4e43\u57fa\u65bc\u672c\u516c\u53f8\u7ba1\u7406\u5c64\u5728\u505a\u51fa\u8868\u8ff0\u6642\u5c0d\u672a\u4f86\u4e8b\u52d9\u7684\u73fe\u6709\u770b\u6cd5\u3001\u5047\u8a2d\u3001\u671f\u671b\u3001\u4f30\u8a08\u3001\u9810\u6e2c\u548c\u7406\u89e3\u3002\u9019\u4e9b\u8868\u8ff0\u4e26\u975e\u5c0d\u672a\u4f86\u767c\u5c55\u7684\u4fdd\u8b49\uff0c\u6703\u53d7\u5230\u98a8\u96aa\u3001\u4e0d\u78ba\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u97ff\uff0c\u6709\u4e9b\u4e43\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u8303\u570d\uff0c\u96e3\u4ee5\u9810\u8a08\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u5011\u7684\u696d\u52d9\u3001\u7af6\u722d\u74b0\u5883\u3001\u653f\u6cbb\u3001\u7d93\u6fdf\u3001\u6cd5\u5f8b\u548c\u793e\u6703\u60c5\u6cc1\u7684\u672a\u4f86\u8b8a\u5316\u53ca\u767c\u5c55\u7684\u5f71\u97ff\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u6703\u8207\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8cc7\u6599\u6709\u8f03\u5927\u5dee\u5225\u3002","og_url":"https:\/\/www.franchise.com.hk\/en\/%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%8c%b9%e5%ba%b7%e5%a5%87%e6%8b%9c%e5%96%ae%e6%8a%97%ef%bc%88il-23p19%e6%8a%97%e9%ab%94%ef%bc%89%e6%b2%bb%e7%99%82%e6%bd%b0%e7%98%8d%e6%80%a7\/22482","og_site_name":"\u9999\u6e2f\u7279\u8a31\u7d93\u71df","article_published_time":"2024-10-16T16:00:00+00:00","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.franchise.com.hk\/en\/%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%8c%b9%e5%ba%b7%e5%a5%87%e6%8b%9c%e5%96%ae%e6%8a%97%ef%bc%88il-23p19%e6%8a%97%e9%ab%94%ef%bc%89%e6%b2%bb%e7%99%82%e6%bd%b0%e7%98%8d%e6%80%a7\/22482#article","isPartOf":{"@id":"https:\/\/www.franchise.com.hk\/en\/%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%8c%b9%e5%ba%b7%e5%a5%87%e6%8b%9c%e5%96%ae%e6%8a%97%ef%bc%88il-23p19%e6%8a%97%e9%ab%94%ef%bc%89%e6%b2%bb%e7%99%82%e6%bd%b0%e7%98%8d%e6%80%a7\/22482"},"author":{"name":"","@id":""},"headline":"\u4fe1\u9054\u751f\u7269\u5ba3\u5e03\u5339\u5eb7\u5947\u62dc\u55ae\u6297\uff08IL-23p19\u6297\u9ad4\uff09\u6cbb\u7642\u6f70\u760d\u6027\u7d50\u8178\u708e\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\u9054\u6210\u4e3b\u8981\u7d42\u9ede","datePublished":"2024-10-16T16:00:00+00:00","dateModified":"2024-10-16T16:00:00+00:00","mainEntityOfPage":{"@id":"https:\/\/www.franchise.com.hk\/en\/%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%8c%b9%e5%ba%b7%e5%a5%87%e6%8b%9c%e5%96%ae%e6%8a%97%ef%bc%88il-23p19%e6%8a%97%e9%ab%94%ef%bc%89%e6%b2%bb%e7%99%82%e6%bd%b0%e7%98%8d%e6%80%a7\/22482"},"wordCount":67,"publisher":{"@id":"https:\/\/www.franchise.com.hk\/en#organization"},"articleSection":["\u672a\u5206\u985e"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.franchise.com.hk\/en\/%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%8c%b9%e5%ba%b7%e5%a5%87%e6%8b%9c%e5%96%ae%e6%8a%97%ef%bc%88il-23p19%e6%8a%97%e9%ab%94%ef%bc%89%e6%b2%bb%e7%99%82%e6%bd%b0%e7%98%8d%e6%80%a7\/22482","url":"https:\/\/www.franchise.com.hk\/en\/%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%8c%b9%e5%ba%b7%e5%a5%87%e6%8b%9c%e5%96%ae%e6%8a%97%ef%bc%88il-23p19%e6%8a%97%e9%ab%94%ef%bc%89%e6%b2%bb%e7%99%82%e6%bd%b0%e7%98%8d%e6%80%a7\/22482","name":"\u4fe1\u9054\u751f\u7269\u5ba3\u5e03\u5339\u5eb7\u5947\u62dc\u55ae\u6297\uff08IL-23p19\u6297\u9ad4\uff09\u6cbb\u7642\u6f70\u760d\u6027\u7d50\u8178\u708e\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\u9054\u6210\u4e3b\u8981\u7d42\u9ede - \u9999\u6e2f\u7279\u8a31\u7d93\u71df","isPartOf":{"@id":"https:\/\/www.franchise.com.hk\/en#website"},"datePublished":"2024-10-16T16:00:00+00:00","dateModified":"2024-10-16T16:00:00+00:00","breadcrumb":{"@id":"https:\/\/www.franchise.com.hk\/en\/%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%8c%b9%e5%ba%b7%e5%a5%87%e6%8b%9c%e5%96%ae%e6%8a%97%ef%bc%88il-23p19%e6%8a%97%e9%ab%94%ef%bc%89%e6%b2%bb%e7%99%82%e6%bd%b0%e7%98%8d%e6%80%a7\/22482#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.franchise.com.hk\/en\/%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%8c%b9%e5%ba%b7%e5%a5%87%e6%8b%9c%e5%96%ae%e6%8a%97%ef%bc%88il-23p19%e6%8a%97%e9%ab%94%ef%bc%89%e6%b2%bb%e7%99%82%e6%bd%b0%e7%98%8d%e6%80%a7\/22482"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.franchise.com.hk\/en\/%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%ae%a3%e5%b8%83%e5%8c%b9%e5%ba%b7%e5%a5%87%e6%8b%9c%e5%96%ae%e6%8a%97%ef%bc%88il-23p19%e6%8a%97%e9%ab%94%ef%bc%89%e6%b2%bb%e7%99%82%e6%bd%b0%e7%98%8d%e6%80%a7\/22482#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9801","item":"https:\/\/www.franchise.com.hk\/en"},{"@type":"ListItem","position":2,"name":"\u4fe1\u9054\u751f\u7269\u5ba3\u5e03\u5339\u5eb7\u5947\u62dc\u55ae\u6297\uff08IL-23p19\u6297\u9ad4\uff09\u6cbb\u7642\u6f70\u760d\u6027\u7d50\u8178\u708e\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\u9054\u6210\u4e3b\u8981\u7d42\u9ede"}]},{"@type":"WebSite","@id":"https:\/\/www.franchise.com.hk\/en#website","url":"https:\/\/www.franchise.com.hk\/en","name":"\u9999\u6e2f\u7279\u8a31\u7d93\u71df","description":"\u9999\u6e2f\u7279\u8a31\u7d93\u71df | Franchise HK","publisher":{"@id":"https:\/\/www.franchise.com.hk\/en#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.franchise.com.hk\/en?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.franchise.com.hk\/en#organization","name":"\u9999\u6e2f\u7279\u8a31\u7d93\u71df","url":"https:\/\/www.franchise.com.hk\/en","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.franchise.com.hk\/en#\/schema\/logo\/image\/","url":"https:\/\/i0.wp.com\/www.franchise.com.hk\/wp-content\/uploads\/2022\/05\/cropped-cropped-franchise-logo-02-e1652686851566-2.png?fit=350%2C76&ssl=1","contentUrl":"https:\/\/i0.wp.com\/www.franchise.com.hk\/wp-content\/uploads\/2022\/05\/cropped-cropped-franchise-logo-02-e1652686851566-2.png?fit=350%2C76&ssl=1","width":350,"height":76,"caption":"\u9999\u6e2f\u7279\u8a31\u7d93\u71df"},"image":{"@id":"https:\/\/www.franchise.com.hk\/en#\/schema\/logo\/image\/"}}]}},"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/www.franchise.com.hk\/en\/wp-json\/wp\/v2\/posts\/22482"}],"collection":[{"href":"https:\/\/www.franchise.com.hk\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.franchise.com.hk\/en\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/www.franchise.com.hk\/en\/wp-json\/wp\/v2\/comments?post=22482"}],"version-history":[{"count":0,"href":"https:\/\/www.franchise.com.hk\/en\/wp-json\/wp\/v2\/posts\/22482\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.franchise.com.hk\/en\/wp-json\/wp\/v2\/media?parent=22482"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.franchise.com.hk\/en\/wp-json\/wp\/v2\/categories?post=22482"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.franchise.com.hk\/en\/wp-json\/wp\/v2\/tags?post=22482"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}