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CPS&lt;5\u4e9e\u7d44\u60a3\u8005\u7684\u4e9e\u7d44\u7642\u6548\u7684\u63a2\u7d22\u6027\u5206\u6790\u7d50\u679c\u5982\u4e0b\uff1a<\/p>\n<p>\u7e3d\u9ad4\u60a3\u8005\u7d44\uff1aCLDN18.2\u9ad8\/\u4e2d\u7b49\u8868\u9054(H\/M)\u60a3\u8005\u7684\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\u70ba12.6\u500b\u6708\uff0c\u4f4e\u8868\u9054(L)\u60a3\u8005\u70ba7.1\u500b\u6708\uff0c\u5176\u4f59\u60a3\u8005(R)\u70ba8.5\u500b\u6708\u3002\u78ba\u8a8d\u5ba2\u89c0\u7de9\u89e3\u7387\u5206\u5225\u70ba58.1%\u3001 52.4%\u548c55.6%\u3002\u7e3d\u9ad4\u4eba\u7fa4\uff08n=82\uff09\u768412\u500b\u6708\u751f\u5b58\u7387\u70ba73.8%\u3002<br \/>\n\u7e3d\u9ad4\u5177\u6709\/\u5df2\u77e5CLDN18.2\/PD-L1\u8868\u9054\u6c34\u5e73\u60a3\u8005\u7d44(n=66)\uff1aCLDN18.2\u9ad8\/\u4e2d\u7b49\u8868\u9054(H\/M)\u60a3\u8005\u7684\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\u70ba14.2\u500b\u6708\uff0c\u4f4e\u8868\u9054(L)\u60a3\u8005\u70ba8.5\u500b\u6708\uff0c\u5176\u4f59\u60a3\u8005(R)\u70ba6.7\u500b\u6708\u3002\u78ba\u8a8d\u5ba2\u89c0\u7de9\u89e3\u7387\u5206\u5225\u70ba68.0%\u3001 61.1%\u548c50.0%\u3002<br \/>\nPD-L1 CPS&lt;5\u4e9e\u7d44\u60a3\u8005(n=56)\uff1aCLDN18.2\u9ad8\/\u4e2d\u7b49\u8868\u9054(H\/M)\u60a3\u8005\u7684\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\u70ba16.6\u500b\u6708\uff0c\u4f4e\u8868\u9054(L)\u60a3\u8005\u70ba7.1\u500b\u6708\uff0c\u5176\u4f59\u60a3\u8005(R)\u70ba5.7\u500b\u6708\u3002\u78ba\u8a8d\u5ba2\u89c0\u7de9\u89e3\u7387\u5206\u5225\u70ba71.4%\u3001 60.0%\u548c47.1%\u3002  <\/p>\n<p>\u53ef\u63a7\u7684\u5b89\u5168\u6027<\/p>\n<p>\u6240\u6709\u60a3\u8005\u5747\u7d93\u6b77\u4e86\u8207\u6cbb\u7642\u76f8\u95dc\u7684\u4e0d\u826f\u4e8b\u4ef6(TRAE)\u3002\u6700\u5e38\u898b\u7684TRAE\u662f\u4f4e\u767d\u86cb\u767d\u8840\u75c7\u3001\u60e1\u5fc3\u548c\u5614\u5410\uff0c\u5176\u4e2d\u5927\u591a\u6578\u70ba\u53ef\u63a7\u7684CTC AE1\u7d1a\u62162\u7d1a\u3002\u5176\u5b89\u5168\u6027\u7279\u5f81\u8207\u6b64\u524d\u5c55\u793a\u7684TST001\u806f\u5408CAPOX\u5927\u9ad4\u4e00\u81f4\uff08\u300a\u81e8\u5e8a\u816b\u7624\u5b78\u96dc\u5fd7\u300b\u7b2c41\u5377\uff0c\u7b2c16\u671f\uff0c 2023\u5e74\uff0c\u6458\u8981#4046\uff09\u3002<\/p>\n<p>\u95dc\u65bcOsemitamab (TST001)<\/p>\n<p>Osemitamab (TST001) \u662f\u4e00\u7a2e\u9ad8\u89aa\u548c\u529b\u7684\u9776\u5411CLDN18.2\u7684\u4eba\u6e90\u5316\u55ae\u514b\u9686\u6297\u9ad4\uff0c\u5177\u6709\u589e\u5f37\u7684\u6297\u9ad4\u4f9d\u8cf4\u6027\u7d30\u80de\u6bd2\u6027\uff08ADCC\uff09\uff0c\u5728\u7570\u7a2e\u79fb\u690d\u8a66\u9a57\u4e2d\u986f\u793a\u51fa\u5f37\u5927\u7684\u6297\u816b\u7624\u6d3b\u6027\u3002Osemitamab (TST001) \u662f\u5168\u7403\u8303\u570d\u5167\u958b\u767c\u7684\u7b2c\u4e8c\u500b\u6700\u5148\u9032\u7684CLDN18.2\u9776\u5411\u6297\u9ad4\u85e5\u7269\uff0c\u7531\u672c\u516c\u53f8\u901a\u904e\u5176\u514d\u75ab\u8010\u53d7\u7a81\u7834(IMTB)\u6280\u8853\u5e73\u53f0\u958b\u767c\u3002Osemitamab (TST001) \u901a\u904eADCC\u6a5f\u5236\u6bba\u6b7b\u8868\u9054CLDN 18.2\u7684\u816b\u7624\u7d30\u80de\u3002\u5229\u7528\u5148\u9032\u7684\u751f\u7269\u52a0\u5de5\u6280\u8853\uff0cOsemitamab (TST001) \u7684\u5dd6\u85fb\u7cd6\u542b\u91cf\u5728\u751f\u7522\u904e\u7a0b\u4e2d\u5927\u5927\u964d\u4f4e\uff0c\u9032\u4e00\u6b65\u589e\u5f37\u4e86Osemitamab (TST001) \u7684NK\u7d30\u80de\u4ecb\u5c0e\u7684ADCC\u6d3b\u6027\u3002\u4e2d\u570b\u548c\u7f8e\u570b\u5747\u4e00\u76f4\u5728\u9032\u884cOsemitamab (TST001) \u7684\u81e8\u5e8a\u8a66\u9a57(TranStar101\/NCT04396821, TranStar102\/NCT04495296)\u3002\u7f8e\u570b\u98df\u54c1\u548c\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40(FDA)\u5df2\u6388\u4e88Osemitamab (TST001) \u7528\u65bc\u6cbb\u7642\u80c3\u764c\u6216\u80c3\u98df\u7ba1\u7d50\u5408\u90e8\u817a\u764c\u548c\u80f0\u817a\u764c\u60a3\u8005\u7684\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\u3002<\/p>\n<p>\u95dc\u65bc\u5275\u52dd\u96c6\u5718<\/p>\n<p>\u5275\u52dd\u96c6\u5718\u662f\u4e00\u5bb6\u81e8\u5e8a\u968e\u6bb5\u7684\u5728\u751f\u7269\u85e5\u767c\u73fe\u3001\u7814\u767c\u3001\u5de5\u85dd\u958b\u767c\u548c\u751f\u7522\u65b9\u9762\u5177\u6709\u5168\u9762\u7d9c\u5408\u80fd\u529b\u7684\u751f\u7269\u5236\u85e5\u516c\u53f8\u3002<\/p>\n<p>\u5275\u52dd\u96c6\u5718\u7e3d\u90e8\u4f4d\u65bc\u8607\u5dde\uff0c\u5df2\u6210\u529f\u642d\u5efa\u4e86\u5168\u7403\u7684\u696d\u52d9\u5e03\u5c40\uff1a\u5728\u8607\u5dde\u8a2d\u6709\u85e5\u7269\u767c\u73fe\u3001\u81e8\u5e8a\u548c\u8f49\u5316\u7814\u7a76\u4e2d\u5fc3\uff0c\u5728\u676d\u5dde\u64c1\u6709\u5de5\u85dd\u8207\u7522\u54c1\u958b\u767c\u4e2d\u5fc3\u4ee5\u53ca\u85e5\u7269\u751f\u7522\u57fa\u5730\uff0c\u5728\u7f8e\u570b\u666e\u6797\u65af\u9813\u3001\u5317\u4eac\u3001\u4e0a\u6d77\u3001\u5ee3\u5dde\u5206\u5225\u8a2d\u6709\u81e8\u5e8a\u958b\u767c\u4e2d\u5fc3\uff0c\u4e26\u5728\u7f8e\u570b\u6ce2\u58eb\u9813\u3001\u6d1b\u6749\u78ef\u8a2d\u7acb\u4e86\u696d\u52d9\u62d3\u5c55\u4e2d\u5fc3\u3002\u5275\u52dd\u96c6\u5718\u7684\u958b\u767c\u7ba1\u7dda\u5df2\u6709\u5341\u56db\u500b\u6cbb\u7642\u7528\u6297\u9ad4\u65b0\u85e5\u5206\u5b50\uff0c\u6db5\u84cb\u816b\u7624\u3001\u9aa8\u79d1\u548c\u814e\u75c5\u7b49\u9818\u57df\u3002<\/p>\n<p>\u5982\u9700\u4e86\u89e3\u95dc\u65bc\u5275\u52dd\u96c6\u5718\u7684\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\u516c\u53f8\u7db2\u7ad9\uff1a<a href=\"http:\/\/www.transcenta.com\/\" target=\"_blank\" rel=\"noopener\">www.transcenta.com<\/a>\u00a0\u6216\u9818\u82f1\u8cec\u865f\uff1aTranscenta\u3002<\/p>\n<p>\u5a92\u9ad4\u806f\u7cfb\uff1a<\/p>\n<p><span class=\"xn-person\">Bryan Cheng<\/span>, <a href=\"mailto:bryan.cheng@transcenta.com\">bryan.cheng@transcenta.com<\/a>, 15067129733<\/p>","protected":false},"excerpt":{"rendered":"<p>\u66f4\u9577\u96a8\u8a2a\u6642\u9593\u7684\u66f4\u65b0\u6578\u64da\u986f\u793a\uff0c CLDN18.2\u9ad8\/\u4e2d\u8868\u9054\u4e14\u5df2\u77e5PD-L1 CPS\u60a3\u8005\u7684\u78ba\u8a8d\u5ba2\u89c0\u7de9\u89e3\u7387(ORR)\u70ba68%\uff0c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f(PFS)\u70ba14.2\u500b\u6708(n=66)\u3002 \u65b0\u6fa4\u897f\u5dde\u666e\u6797\u65af\u9813\u548c\u8607\u5dde2024\u5e749\u670819\u65e5\u00a0 \/\u7f8e\u901a\u793e\/ &#8212; \u5275\u52dd\u96c6\u5718\uff0806628.HK\uff09\uff0c\u4e00\u5bb6\u5177\u5099\u751f\u7269\u85e5\u54c1\u767c\u73fe\u3001\u7814\u767c\u3001\u5de5\u85dd\u958b\u767c\u548c\u751f\u7522\u5168\u6d41\u7a0b\u6574\u5408\u80fd\u529b\u7684\u81e8\u5e8a\u968e\u6bb5\u7684\u570b\u969b\u751f\u7269\u5236\u85e5\u516c\u53f8\uff0c\u4eca\u65e5\u516c\u5e03Osemitamab (TST001)\u806f\u5408\u7d0d\u6b66\u5229\u5c24\u55ae\u6297\u548cCAPOX\u4f5c\u70ba\u665a\u671f\u80c3\u6216\u80c3\u98df\u7ba1\u7d50\u5408\u90e8\u817a\u764c(TranStar102)\u4e00\u7dda\u6cbb\u7642\u7684G\u968a\u5217\u66f4\u65b0\u7814\u7a76\u6578\u64da\u3002\u8a72\u968a\u5217\u7684\u6578\u64da\u81eaASCO 2024\u5e74\u6703\u516c\u5e03\u4ee5\u4f86\uff0c\u6301\u7e8c\u986f\u793a\u51fa\u4ee4\u4eba\u9f13\u821e\u7684\u7642\u6548\u3002 \u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u5728\u5df2\u77e5CLDN18.2\u548cPD-L1\u8868\u9054\u6c34\u5e73\u7684\u60a3\u8005\u4e2d\uff0c CLDN18.2\u9ad8\/\u4e2d\u8868\u9054\u60a3\u8005\u7684\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f(mPFS)\u70ba14.2\u500b\u6708\uff0c\u78ba\u8a8d\u5ba2\u89c0\u7de9\u89e3\u7387\u70ba68%\u3002\u5176\u4e2d\u7d55\u5927\u90e8\u5206\u60a3\u8005\u662fPD-L1 CPS&lt;5\u3002 \u4ee5CLDN18.2\u6975\u4f4e\/\u7121\u8868\u9054\u7684\u60a3\u8005\u7fa4\u9ad4\u4f5c\u70ba\u66ff\u4ee3\u5c0d\u7167\u7d44\uff0c\u4e09\u806f\u7642\u6cd5\u5728CLDN18.2\u9ad8\/\u4e2d\u8868\u9054\uff08\u7121\u8ad6CPS\u8868\u9054\u6c34\u5e73\u5982\u4f55\uff09\u7684\u60a3\u8005\u7fa4\u9ad4\u4e2d\uff0c\u964d\u4f4e\u4e8650%\u7684\u75be\u75c5\u9032\u5c55\u6216\u6b7b\u4ea1\u7684\u98a8\u96aa(HR\u70ba0.505\uff0c 95%CI, 0.244-1.045)\u3002\u8a72\u6578\u64da\u9032\u4e00\u6b65\u8b49\u5be6\u4e86\u672c\u516c\u53f8\u5728ESMO 2023\u5e74\u6703\u4e0a\u5831\u544a\u7684CLDN18.2\u9776\u5411\u85e5\u7269\u8207\u6aa2\u67e5\u9ede\u6291\u5236\u5291\u4e4b\u9593\u5b58\u5728\u5354\u540c\u4f5c\u7528\u6a5f\u5236\uff0c\u5373CLDN18.2\u9776\u5411\u6297\u9ad4\u751a\u81f3\u80fd\u5920\u5728PD-L1\u4f4e\u6216\u7121\u8868\u9054\u7684\u80c3\u764c\u816b\u7624\u7d30\u80de\u4e2d\u8a98\u5c0ePD-L1\u8868\u9054\u548cT\u7d30\u80de\u6d78\u6f64\u3002\u622a\u81f3\u6578\u64da\u7d71\u8a08\u65e5\u671f\uff0c\u7531\u65bc\u4e8b\u4ef6\u6578\u91cf\u6709\u9650\uff0c\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\u5c1a\u672a\u9054\u5230\uff0c\u8a72\u968a\u5217\u4e2d\u7e3d\u9ad4\u4eba\u7fa4\uff0882\u540d\u60a3\u8005\uff09\u768412\u500b\u6708\u751f\u5b58\u7387\u70ba73.8%\uff0895% CI\uff1a62.0-82.4%\uff09\u3002 \u5148\u524d\u7814\u7a76\u767c\u73fe\uff0c\u7121\u8ad6PD-L1\u8868\u9054\u6c34\u5e73\u5982\u4f55\uff0c Zolbetuximab\u548cCAPOX\u7684\u806f\u7528\u53ef\u4ee5\u5c07CLDN18.2\u967d\u6027\u60a3\u8005\u7684\u7121\u9032\u5c55\u751f\u5b58\u671f\u5f9e6.80\u500b\u6708\u63d0\u9ad8\u81f38.21\u500b\u6708\uff08 HR=0.687\uff0895% CI\uff0c 0.544-0.866\uff09\uff08\u4f86\u6e90\uff1aShah, Manish A et al. Nature Medicine 2023 Aug 29 (8): 2133-2141\uff09\u3002\u66f4\u65b0\u7684Cohort-G\u7814\u7a76\u6578\u64da\u986f\u793a\uff0c Osemitamab (TST001)\u806f\u5408Nivolumab\u548cCAPOX\uff0c\u5728\u7642\u6548\u4e0a\u986f\u8457\u512a\u65bcNivolumab\u806f\u5408CAPOX\u6216Zolbetuximab\u806f\u5408CAPOX\u7684\u6cbb\u7642\u65b9\u6848\u3002 \u66f4\u65b0\u6578\u64da\u4ee5\u7246\u5831\u5f62\u5f0f\uff08\u6458\u8981#1419p\uff09\u5df2\u65bc2024\u5e749\u670816\u65e5\u5728\u897f\u73ed\u7259\u5df4\u585e\u7f85\u90a3\u8209\u8fa6\u7684ESMO 2024\u5e74\u6703\u516c\u5e03\u3002 \u300cCohort-G\u8a66\u9a57\u7684\u66f4\u65b0\u6578\u64da\u8868\u660e\uff0cOsemitamab (TST001)\u806f\u5408Nivolumab\u548cCAPOX\u4f5c\u70ba\u665a\u671f\u80c3\u6216\u80c3\u98df\u7ba1\u7d50\u5408\u90e8\u817a\u764c\u4e00\u7dda\u6cbb\u7642\u7684\u7642\u6548\u4ee4\u4eba\u9f13\u821e\u3002\u8207CLDN18.2\u4e0d\u8868\u9054\u7684\u60a3\u8005\u76f8\u6bd4\uff0cCLDN18.2\u9ad8\/\u4e2d\u8868\u9054\u4e14\u5df2\u77e5PD-L1\u8868\u9054\u6c34\u5e73\u60a3\u8005\u7684\u78ba\u8a8d\u5ba2\u89c0\u7de9\u89e3\u7387\u548c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\u8b49\u5be6\u4e86Osemitamab (TST001)\u8207\u6aa2\u67e5\u9ede\u6291\u5236\u5291\u4e4b\u9593\u7684\u5354\u540c\u4f5c\u7528\uff0c\u5c55\u793a\u4e86\u4e09\u806f\u7642\u6cd5\u7684\u6f5b\u529b\uff0c\u4e26\u4e14\u6709\u53ef\u80fd\u60e0\u53caPD-L1\u4f4e\u8868\u9054\u60a3\u8005\uff0c\u300d\u5275\u52dd\u96c6\u5718\u5168\u7403\u85e5\u7269\u958b\u767c\u57f7\u884c\u526f\u7e3d\u88c1\uff0c\u9996\u5e2d\u91ab\u5b78\u5b98Caroline Germa\u535a\u58eb\u8868\u793a\uff0c\u300c\u9019\u4e9b\u81e8\u5e8a\u7d50\u679c\u7a81\u986f\u4e86Osemitamab (TST001)\u5728\u6539\u5584\u665a\u671f\u80c3\u6216\u80c3\u98df\u7ba1\u7d50\u5408\u90e8\u817a\u764c\u60a3\u8005\u9810\u5f8c\u65b9\u9762\u7684\u524d\u666f\u3002\u300d 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Nature Medicine 2023 Aug 29 (8): 2133-2141\uff09\u3002\u66f4\u65b0\u7684Cohort-G\u7814\u7a76\u6578\u64da\u986f\u793a\uff0c Osemitamab (TST001)\u806f\u5408Nivolumab\u548cCAPOX\uff0c\u5728\u7642\u6548\u4e0a\u986f\u8457\u512a\u65bcNivolumab\u806f\u5408CAPOX\u6216Zolbetuximab\u806f\u5408CAPOX\u7684\u6cbb\u7642\u65b9\u6848\u3002 \u66f4\u65b0\u6578\u64da\u4ee5\u7246\u5831\u5f62\u5f0f\uff08\u6458\u8981#1419p\uff09\u5df2\u65bc2024\u5e749\u670816\u65e5\u5728\u897f\u73ed\u7259\u5df4\u585e\u7f85\u90a3\u8209\u8fa6\u7684ESMO 2024\u5e74\u6703\u516c\u5e03\u3002 \u300cCohort-G\u8a66\u9a57\u7684\u66f4\u65b0\u6578\u64da\u8868\u660e\uff0cOsemitamab (TST001)\u806f\u5408Nivolumab\u548cCAPOX\u4f5c\u70ba\u665a\u671f\u80c3\u6216\u80c3\u98df\u7ba1\u7d50\u5408\u90e8\u817a\u764c\u4e00\u7dda\u6cbb\u7642\u7684\u7642\u6548\u4ee4\u4eba\u9f13\u821e\u3002\u8207CLDN18.2\u4e0d\u8868\u9054\u7684\u60a3\u8005\u76f8\u6bd4\uff0cCLDN18.2\u9ad8\/\u4e2d\u8868\u9054\u4e14\u5df2\u77e5PD-L1\u8868\u9054\u6c34\u5e73\u60a3\u8005\u7684\u78ba\u8a8d\u5ba2\u89c0\u7de9\u89e3\u7387\u548c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\u8b49\u5be6\u4e86Osemitamab (TST001)\u8207\u6aa2\u67e5\u9ede\u6291\u5236\u5291\u4e4b\u9593\u7684\u5354\u540c\u4f5c\u7528\uff0c\u5c55\u793a\u4e86\u4e09\u806f\u7642\u6cd5\u7684\u6f5b\u529b\uff0c\u4e26\u4e14\u6709\u53ef\u80fd\u60e0\u53caPD-L1\u4f4e\u8868\u9054\u60a3\u8005\uff0c\u300d\u5275\u52dd\u96c6\u5718\u5168\u7403\u85e5\u7269\u958b\u767c\u57f7\u884c\u526f\u7e3d\u88c1\uff0c\u9996\u5e2d\u91ab\u5b78\u5b98Caroline Germa\u535a\u58eb\u8868\u793a\uff0c\u300c\u9019\u4e9b\u81e8\u5e8a\u7d50\u679c\u7a81\u986f\u4e86Osemitamab (TST001)\u5728\u6539\u5584\u665a\u671f\u80c3\u6216\u80c3\u98df\u7ba1\u7d50\u5408\u90e8\u817a\u764c\u60a3\u8005\u9810\u5f8c\u65b9\u9762\u7684\u524d\u666f\u3002\u300d 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