{"id":19961,"date":"2024-06-25T00:12:00","date_gmt":"2024-06-24T16:12:00","guid":{"rendered":"https:\/\/www.franchise.com.hk\/%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%9c%a82024%e5%b9%b4%e7%be%8e%e5%9c%8b%e7%b3%96%e5%b0%bf%e7%97%85%e5%8d%94%e6%9c%83%ef%bc%88ada%ef%bc%89%e7%a7%91%e5%ad%b8%e6%9c%83%e8%ad%b0%e5%85%ac%e4%bd%88glp\/19961"},"modified":"2024-06-25T00:12:00","modified_gmt":"2024-06-24T16:12:00","slug":"%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%9c%a82024%e5%b9%b4%e7%be%8e%e5%9c%8b%e7%b3%96%e5%b0%bf%e7%97%85%e5%8d%94%e6%9c%83%ef%bc%88ada%ef%bc%89%e7%a7%91%e5%ad%b8%e6%9c%83%e8%ad%b0%e5%85%ac%e4%bd%88glp","status":"publish","type":"post","link":"https:\/\/www.franchise.com.hk\/en\/%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%9c%a82024%e5%b9%b4%e7%be%8e%e5%9c%8b%e7%b3%96%e5%b0%bf%e7%97%85%e5%8d%94%e6%9c%83%ef%bc%88ada%ef%bc%89%e7%a7%91%e5%ad%b8%e6%9c%83%e8%ad%b0%e5%85%ac%e4%bd%88glp\/19961","title":{"rendered":"\u4fe1\u9054\u751f\u7269\u57282024\u5e74\u7f8e\u570b\u7cd6\u5c3f\u75c5\u5354\u6703\uff08ADA\uff09\u79d1\u5b78\u6703\u8b70\u516c\u4f48GLP-1\/GCGR\u96d9\u91cd\u6fc0\u52d5\u5291\u7684\u5168\u7403\u9996\u500b\u6e1b\u91cdIII\u671f\u81e8\u5e8a\uff1a\u746a\u4ed5\u5ea6\u80bdGLROY-1\u7814\u7a76\u7d50\u679c"},"content":{"rendered":"

\u7f8e\u570b\u820a\u91d1\u5c71\u548c\u4e2d\u570b\u8607\u5dde<\/span>2024\u5e746\u670825\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u80a1\u7968\u4ee3\u78bc\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u53ca\u5fc3\u8840\u7ba1\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u5275\u65b0\u85e5\u7269\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\u5ba3\u4f48\uff1a\u80f0\u9ad8\u8840\u7cd6\u7d20\u6a23\u80bd-1\u53d7\u9ad4\uff08GLP-1R\uff09\/\u80f0\u9ad8\u8840\u7cd6\u7d20\u53d7\u9ad4\uff08GCGR\uff09\u96d9\u91cd\u6fc0\u52d5\u5291\u746a\u4ed5\u5ea6\u80bd\uff08\u7814\u767c\u4ee3\u865f\uff1aIBI362\uff09\u5728\u4e2d\u570b\u8d85\u91cd\u6216\u80a5\u80d6\u6210\u4eba\u53d7\u8a66\u8005\u4e2d\u7684\u9996\u500bIII\u671f\u81e8\u5e8a\u7814\u7a76\uff08GLORY-1\uff09\u7684\u4e3b\u8981\u7d50\u679c\u53ca\u809d\u81df\u8102\u80aa\u542b\u91cf\u63a2\u7d22\u6027\u7d42\u9ede\u7d50\u679c\u57282024\u5e74\u7f8e\u570b\u7cd6\u5c3f\u75c5\u5354\u6703\uff08ADA\uff09\u79d1\u5b78\u6703\u8b70\u4e0a\u5206\u5225\u4ee5\u91cd\u78c5\u9032\u5c55\u53e3\u982d\u5831\u544a\uff08ePoster Theater, 1856-LB<\/a>\uff09\u548c\u91cd\u78c5\u9032\u5c55\u6458\u8981\uff081857-LB<\/a>\uff09\u7684\u5f62\u5f0f\u767c\u8868\u3002<\/p>\n

GLORY-1\u7684\u4e3b\u8981\u7d42\u9ede\u548c\u95dc\u9375\u6b21\u8981\u7d42\u9ede\u5747\u9806\u5229\u9054\u6210\uff0c\u518d\u6b21\u5370\u8b49\u4e86GLP-1R\/GCGR\u96d9\u91cd\u6fc0\u52d5\u5291\u7684\u7368\u7279\u512a\u52e2<\/p>\n

\u746a\u4ed5\u5ea6\u80bd\u53ef\u540c\u6642\u6fc0\u52d5GLP-1R\u548cGCGR\u3002\u901a\u904e\u6fc0\u52d5GLP-1R\u6291\u5236\u98df\u617e\u548c\u5ef6\u7de9\u80c3\u6392\u7a7a\uff0c\u5f9e\u800c\u9054\u5230\u6e1b\u8f15\u9ad4\u91cd\u7684\u529f\u6548\uff1b\u540c\u6642\u901a\u904e\u6fc0\u52d5GCGR\u589e\u52a0\u80fd\u91cf\u6d88\u8017\uff0c\u589e\u5f37\u6e1b\u91cd\u7642\u6548\u3002\u7279\u5225\u662f\uff0c\u746a\u4ed5\u5ea6\u80bd\u9084\u80fd\u7368\u7279\u5730\u901a\u904e\u5c0d\u809d\u81dfGCGR\u7684\u6fc0\u6d3b\uff0c\u4fc3\u9032\u8102\u80aa\u9178\u6c27\u5316\u548c\u8102\u80aa\u5206\u89e3\uff0c\u6539\u5584\u809d\u81df\u8102\u80aa\u4ee3\u8b1d\u3002<\/p>\n

GLORY-1\u7684\u7814\u7a76\u7d50\u679c\u4e0d\u50c5\u8b49\u660e\u4e86\u746a\u4ed5\u5ea6\u80bd\u512a\u7570\u7684\u6e1b\u91cd\u7642\u6548\uff0c\u4ee5\u53ca\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u540c\u6642\u9084\u89c0\u5bdf\u5230\u7368\u7279\u7684\u809d\u81df\u8102\u80aa\u542b\u91cf\u5927\u5e45\u4e0b\u964d\uff0c\u4ee5\u53ca\u591a\u500b\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u98a8\u96aa\u6307\u6a19\u7684\u6539\u5584\uff0c\u518d\u6b21\u5370\u8b49\u4e86GLP-1R\/GCGR\u96d9\u91cd\u6fc0\u52d5\u5291\u7684\u7368\u7279\u512a\u52e2\u3002\u746a\u4ed5\u5ea6\u80bd\u9996\u500b\u6e1b\u91cd\u9069\u61c9\u75c7\u7684\u4e0a\u5e02\u7533\u8acb\u6b63\u5728\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u7684\u5be9\u8a55\u904e\u7a0b\u4e2d\u3002\u746a\u4ed5\u5ea6\u80bd\u6709\u671b\u70ba\u4e2d\u570b\u80a5\u80d6\u53ca\u8d85\u91cd\u4eba\u7fa4\u63d0\u4f9b\u5b89\u5168\u5f37\u6548\u4e26\u5168\u9762\u6539\u5584\u4ee3\u8b1d\u7684\u9ad4\u91cd\u7ba1\u7406\u65b9\u6848\u3002<\/p>\n

GLORY-1\u7684\u5b8c\u6574\u7d50\u679c\u5c07\u5728\u5b78\u8853\u671f\u520a\u767c\u8868\u3002\u746a\u4ed5\u5ea6\u80bd\u5728\u5df2\u958b\u5c55\u768417\u9805\u81e8\u5e8a\u7814\u7a76\u4e2d\u5df2\u7d2f\u8a08\u8d85\u904e1,500\u4eba\u7684\u66b4\u9732\u91cf\uff0c\u70ba\u4e2d\u570b\u80a5\u80d6\u548c\u7cd6\u5c3f\u75c5\u9632\u6cbb\u63d0\u4f9b\u4e86\u9ad8\u8cea\u91cf\u7684\u5faa\u8b49\u91ab\u5b78\u8b49\u64da\u3002<\/p>\n

GLORY-1\uff08ClinicalTrial.gov\uff1aNCT05607680\uff09\u662f\u4e00\u9805\u5728\u4e2d\u570b\u8d85\u91cd\uff08BMI\u226524 kg\/m2\uff09\u4f34\u6709\u81f3\u5c11\u4e00\u7a2e\u9ad4\u91cd\u76f8\u95dc\u5408\u4f75\u75c7\u6216\u80a5\u80d6\uff08BMI\u226528 kg\/m2\uff09\u53d7\u8a66\u8005\u4e2d\u8a55\u4f30\u746a\u4ed5\u5ea6\u80bd\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u7684\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\u3002\u5171\u5165\u7d44610\u4f8b\u53d7\u8a66\u8005\uff0c\u63091\uff1a1\uff1a1\u96a8\u6a5f\u5206\u914d\u81f3\u746a\u4ed5\u5ea6\u80bd4 mg\u7d44\uff08N=203\uff09\u3001\u746a\u4ed5\u5ea6\u80bd6 mg\u7d44\uff08N=202\uff09\u6216\u5b89\u6170\u5291\u7d44\uff08N=205\uff09\uff0c\u6cbb\u764248\u5468\u3002<\/p>\n

\u746a\u4ed5\u5ea6\u80bd\u7684\u6e1b\u91cd\u7642\u6548\u986f\u8457\u512a\u65bc\u5b89\u6170\u5291\u7d44<\/p>\n

\u5728\u7b2c32\u5468\u548c48\u5468\u6642\u9ad4\u91cd\u8f03\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316\uff0c\u4ee5\u53ca\u9ad4\u91cd\u8f03\u57fa\u7dda\u964d\u5e45\u22655%\uff0c\u226510%\u548c\u226515%\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u4e0a\uff0c\u746a\u4ed5\u5ea6\u80bd4 mg\u548c6 mg\u5747\u512a\u65bc\u5b89\u6170\u5291\uff08P<0.001\uff09\uff1b\u5176\u4e2d\uff0c\u5728\u7642\u6cd5\u4f30\u8a08\u76ee\u6a19\u548c\u7642\u6548\u4f30\u8a08\u76ee\u6a19\u4e0b\uff0c\u7b2c48\u5468\u6642\u746a\u4ed5\u5ea6\u80bd6mg\u7d44\u76f8\u8f03\u5b89\u6170\u5291\u7d44\u7684\u5dee\u503c\u5206\u5225\u70ba14.31%\u548c14.37%\u3002\u8a73\u7d30\u7d50\u679c\u898b\u4e0b\u8868\uff1a<\/p>\n

\n

<\/p>\n

\u7642\u6cd5\u4f30\u8a08\u76ee\u6a19*<\/span><\/p>\n

\u7642\u6548\u4f30\u8a08\u76ee\u6a19\u2020<\/span><\/p>\n

\u746a\u4ed5\u5ea6\u80bd\u00a04 mg (N=203)<\/span><\/p>\n

\u746a\u4ed5\u5ea6\u80bd\u00a06 mg (N=202)<\/span><\/p>\n

\u5b89\u6170\u5291<\/span><\/p>\n

\u00a0(N=205)<\/span><\/p>\n

\u746a\u4ed5\u5ea6\u80bd\u00a04 mg (N=203)<\/span><\/p>\n

\u746a\u4ed5\u5ea6\u80bd\u00a06 mg (N=202)<\/span><\/p>\n

\u5b89\u6170\u5291\u00a0(N=205)<\/span><\/p>\n

\u9996\u8981\u7d42\u9ede\u00b6<\/span><\/p>\n

\u7b2c<\/span>32<\/span>\u5468\u6642\u9ad4\u91cd\u8f03\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316<\/span>, %<\/span><\/p>\n

\u221210.09 <\/span><\/p>\n

\u221212.55 <\/span><\/p>\n

0.45<\/span><\/p>\n

\u221210.97 <\/span><\/p>\n

\u221213.38 <\/span><\/p>\n

\u22120.24 <\/span><\/p>\n

\u8207\u5b89\u6170\u5291\u7d44\u7684\u5dee\u7570\u00a0(97.5% CI)<\/span><\/p>\n

\u221210.54<\/span><\/p>\n

\u00a0(\u221212.01, \u22129.08)<\/span><\/p>\n

\u221213.00 <\/span><\/p>\n

(\u221214.49,\u221211.51)<\/span><\/p>\n

<\/p>\n

\u221210.72<\/span><\/p>\n

\u00a0(\u221212.21,\u22129.23)<\/span><\/p>\n

\u221213.14 <\/span><\/p>\n

(\u221214.64,\u221211.64)<\/span><\/p>\n

<\/p>\n

\u7b2c<\/span>32<\/span>\u5468\u6642\u9ad4\u91cd\u8f03\u57fa\u7dda\u964d\u5e45<\/span>\u2265<\/span>5% <\/span>\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b<\/span>, %\u00a7<\/span><\/p>\n

73.9<\/span><\/p>\n

82.0<\/span><\/p>\n

10.5<\/span><\/p>\n

76.3<\/span><\/p>\n

84.0<\/span><\/p>\n

10.9<\/span><\/p>\n

\u9ad4\u91cd\u95dc\u9375\u6b21\u8981\u7d42\u9ede\u00b6<\/span><\/p>\n

\u7b2c<\/span>48<\/span>\u5468\u6642\u9ad4\u91cd\u8f03\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316<\/span>, %<\/span><\/p>\n

\u221211.00 <\/span><\/p>\n

\u221214.01 <\/span><\/p>\n

0.30<\/span><\/p>\n

\u221212.05 <\/span><\/p>\n

\u221214.84 <\/span><\/p>\n

\u22120.47 <\/span><\/p>\n

\u8207\u5b89\u6170\u5291\u7d44\u7684\u5dee\u7570\u00a0(97.5% CI)<\/span><\/p>\n

\u221211.30 <\/span><\/p>\n

(\u221213.06, \u22129.54)<\/span><\/p>\n

\u221214.31 <\/span><\/p>\n

(\u221216.11,\u221212.51)<\/span><\/p>\n

<\/p>\n

\u221211.58<\/span><\/p>\n

(\u221213.38, \u22129.79)<\/span><\/p>\n

\u221214.37 <\/span><\/p>\n

(\u221216.18,\u221212.56)<\/span><\/p>\n

<\/p>\n

\u7b2c<\/span>48<\/span>\u5468\u6642\u9ad4\u91cd\u8f03\u57fa\u7dda\u964d\u5e45\u2265<\/span>5% <\/span>\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b<\/span>, %\u00a7<\/span><\/p>\n

71.6<\/span><\/p>\n

81.6<\/span><\/p>\n

10.8<\/span><\/p>\n

73.5<\/span><\/p>\n

82.8<\/span><\/p>\n

11.5<\/span><\/p>\n

\u7b2c<\/span>48<\/span>\u5468\u6642\u9ad4\u91cd\u8f03\u57fa\u7dda\u964d\u5e45<\/span>\u2265<\/span>10% <\/span>\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b<\/span>, %\u00a7<\/span><\/p>\n

53.5<\/span><\/p>\n

66.7<\/span><\/p>\n

2.6<\/span><\/p>\n

55.2<\/span><\/p>\n

67.9<\/span><\/p>\n

2.9<\/span><\/p>\n

\u7b2c<\/span>48<\/span>\u5468\u6642\u9ad4\u91cd\u8f03\u57fa\u7dda\u964d\u5e45<\/span>\u2265<\/span>15% <\/span>\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b<\/span>, %\u00a7<\/span><\/p>\n

35.7<\/span><\/p>\n

49.5<\/span><\/p>\n

2.0<\/span><\/p>\n

37.0<\/span><\/p>\n

50.6<\/span><\/p>\n

2.1<\/span><\/p>\n

<\/p>\n

\u8f03\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316\u548c\u8b8a\u5316\u503c\u70ba\u6700\u5c0f\u4e8c\u4e58\u5747\u503c\u3002\u8207\u5b89\u6170\u5291\u7d44\u7684\u5dee\u7570\u70ba\u6700\u5c0f\u4e8c\u4e58\u5747\u503c\uff08\u7f6e\u4fe1\u5340\u9593\uff09\u3002<\/span><\/p>\n

* \u7642\u6cd5\u4f30\u8a08\u76ee\u6a19\u4ee3\u8868\u7121\u8ad6\u662f\u5426\u4f9d\u5f9e\u65b9\u6848\u5b8c\u6210\u7814\u7a76\u85e5\u7269\u6cbb\u7642\uff0c\u746a\u4ed5\u5ea6\u80bd\u76f8\u5c0d\u5b89\u6170\u5291\u7684\u7642\u6548\u3002\u5728\u7642\u6cd5\u4f30\u8a08\u76ee\u6a19\u4e2d\uff0c\u9023\u7e8c\u8b8a\u91cf\u7d42\u9ede\u4f7f\u7528\u5354\u65b9\u5dee\u5206\u6790\uff08ANCOVA\uff09\uff0c\u5206\u985e\u8b8a\u91cf\u4f7f\u7528\u56de\u6b78\u5206\u6790\u3002\u00a0<\/span><\/p>\n

\u2020 \u7642\u6548\u4f30\u8a08\u76ee\u6a19\u4ee3\u8868\u5982\u679c\u4f9d\u5f9e\u65b9\u6848\u5b8c\u6210\u746a\u4ed5\u5ea6\u80bd\u5168\u7a0b\u6cbb\u7642\uff0c\u746a\u4ed5\u5ea6\u80bd\u76f8\u5c0d\u5b89\u6170\u5291\u7684\u7642\u6548\u3002\u5728\u7642\u6cd5\u4f30\u8a08\u76ee\u6a19\u4e2d\uff0c\u9023\u7e8c\u8b8a\u91cf\u7d42\u9ede\u4f7f\u7528\u91cd\u8907\u6e2c\u91cf\u7684\u6df7\u5408\u6548\u61c9\u6a21\u578b\uff08MMRM\uff09\uff0c\u5206\u985e\u8b8a\u91cf\u4f7f\u7528\u56de\u6b78\u5206\u6790\u3002<\/span><\/p>\n

\u00a7 \u586b\u88dc\u5f8c\u61c9\u7b54\u7387\u3002\u00a0<\/span><\/p>\n

\u00b6 P<0.0001\uff08\u96d9\u5074\uff09\uff0c\u512a\u6548\u65bc\u5b89\u6170\u5291, \u63a7\u5236I\u985e\u932f\u8aa4\u3002\u00a0<\/span><\/p>\n<\/div>\n

\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u00a0\u00a0 \u00a0 \u00a0 \u00a0 \u00a0<\/p>\n

\u746a\u4ed5\u5ea6\u80bd\u986f\u8457\u964d\u4f4e\u591a\u500b\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u98a8\u96aa\u6307\u6a19<\/p>\n

\u5728\u7b2c48\u5468\u6642\uff0c\u8170\u570d\u3001\u6536\u7e2e\u58d3\u3001\u7518\u6cb9\u4e09\u916f\u3001\u7e3d\u81bd\u56fa\u9187\u3001LDL-C\u3001\u8840\u5c3f\u9178\u548cALT\u8f03\u57fa\u7dda\u7684\u8b8a\u5316\u4e0a\uff0c\u746a\u4ed5\u5ea6\u80bd\u5747\u512a\u65bc\u5b89\u6170\u5291\uff08P<0.001\uff09\u3002<\/p>\n

\u7642\u6548\u4f30\u8a08\u76ee\u6a19\u4e0b\uff0c\u7b2c48\u5468\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd4mg\uff0c\u746a\u4ed5\u5ea6\u80bd6mg\u548c\u5b89\u6170\u5291\u7d44\u8170\u570d\u8f03\u57fa\u7dda\u5206\u5225\u4e0b\u964d\u22129.48 cm, \u221210.96 cm \u548c \u22121.48 cm; \u746a\u4ed5\u5ea6\u80bd\u5408\u8a08\u7d44\uff084mg \u548c 6mg\uff09\u76f8\u8f03\u5b89\u6170\u5291\u7d44\u4e5f\u986f\u8457\u964d\u4f4e\u6536\u7e2e\u58d3\uff08\u22129.21 mmHg vs. \u22122.46 mmHg\uff09\u3001\u7518\u6cb9\u4e09\u916f\uff08\u22120.68 mmol\/L vs. -0.16 mmol\/L\uff09\u3001\u7e3d\u81bd\u56fa\u9187\uff08-0.32 mmol\/L vs. 0.13 mmol\/L\uff09\u3001LDL-C\uff08-0.22 mmol\/L vs. 0.09 mmol\/L\uff09\u3001\u8840\u5c3f\u9178\uff08\u221244.79 \u03bcmol\/L vs. 5.96 \u03bcmol\/L\uff09\u548cALT\uff08\u221214.50 U\/L vs.-4.50 U\/L\uff09\u3002 <\/p>\n

\u746a\u4ed5\u5ea6\u80bd\u5927\u5e45\u5ea6\u964d\u4f4e\u809d\u81df\u8102\u80aa\u542b\u91cf<\/p>\n

\u5728GLORY-1\u7684\u63a2\u7d22\u6027\u5206\u6790\u4e2d\uff0c\u5c0d\u57fa\u7dda\u809d\u81df\u8102\u80aa\u542b\u91cf\uff08MRI-PDFF\uff09\u226510%\u7684\u53d7\u8a66\u8005\uff0c\u746a\u4ed5\u5ea6\u80bd6 mg\u7d44\u53d7\u8a66\u8005\u6cbb\u764248\u5468\u5f8c\uff0c\u809d\u81df\u8102\u80aa\u542b\u91cf\u8f03\u57fa\u7dda\u5e73\u5747\u4e0b\u964d\u905480.2%\uff0c\u5b89\u6170\u5291\u7d44\u4e0b\u964d5.3%\u3002[\u8a73\u898b\u5831\u9053<\/span><\/a>] <\/p>\n

\u8010\u53d7\u6027\u548c\u5b89\u5168\u6027\u826f\u597d\uff0c\u7121\u65b0\u589e\u5b89\u5168\u6027\u4fe1\u865f<\/p>\n

\u746a\u4ed5\u5ea6\u80bd\u7684\u8010\u53d7\u6027\u826f\u597d\uff0c\u746a\u4ed5\u5ea6\u80bd4 mg\u548c6 mg\u7d44\u56e0\u4e0d\u826f\u4e8b\u4ef6\u5c0e\u81f4\u7814\u7a76\u85e5\u7269\u505c\u7528\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u5206\u52251.5%\u548c0.5%\uff0c\u5b89\u6170\u5291\u7d44\u70ba1.0%\u3002 \u746a\u4ed5\u5ea6\u80bd\u7684\u6574\u9ad4\u5b89\u5168\u6027\u7279\u5fb5\u8207\u746a\u4ed5\u5ea6\u80bd\u7684\u65e2\u5f80\u81e8\u5e8a\u7814\u7a76\u4ee5\u53caGLP-1R\u6fc0\u52d5\u5291\u985e\u85e5\u7269\u76f8\u4f3c\uff0c\u672a\u767c\u73fe\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002\u80c3\u8178\u9053\u75c7\u72c0\uff08\u5641\u5fc3\u3001\u8179\u7009\u548c\u5614\u5410\uff09\u662f\u6700\u5e38\u767c\u751f\u7684\u4e0d\u826f\u4e8b\u4ef6\uff0c\u7d55\u5927\u591a\u6578\u70ba\u8f15\u5ea6\u6216\u4e2d\u5ea6\uff0c\u4e14\u5927\u90e8\u5206\u767c\u751f\u65bc\u6ef4\u5b9a\u671f\u3002 \u746a\u4ed5\u5ea6\u80bd\u7d44\u7684\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\u767c\u751f\u7387\u4f4e\uff0c\u8207\u5b89\u6170\u5291\u7d44\u76f8\u7576\u3002 48\u5468\u6cbb\u7642\u671f\u9593\uff0c\u746a\u4ed5\u5ea6\u80bd4 mg\u548c6 mg\u7d44\u5fc3\u7387\u8f03\u57fa\u7dda\u7684\u8b8a\u5316\u5747\u503c\u672a\u8d85\u904e5\u6b21\/\u5206\u3002\u7b2c48\u5468\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd4 mg\u548c6 mg\u7d44\u7684\u5fc3\u7387\u8f03\u57fa\u7dda\u8b8a\u5316\u5747\u503c\u5747\u70ba1.6\u6b21\/\u5206\u3002\u7814\u7a76\u671f\u9593\u672a\u898b\u5fc3\u8840\u7ba1\u98a8\u96aa\u589e\u52a0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002 <\/p>\n

\u8a72\u7814\u7a76\u7684\u727d\u982d\u7814\u7a76\u8005\u3001\u5317\u4eac\u5927\u5b78\u4eba\u6c11\u91ab\u9662\u7d00\u7acb\u8fb2\u6559\u6388\u8868\u793a\uff1a\u300c\u8d85\u91cd\u548c\u80a5\u80d6\u662f\u591a\u7a2e\u4f75\u767c\u75c7\u7684\u5371\u96aa\u56e0\u7d20\uff0c\u5176\u4e2d\u6700\u5e38\u898b\u7684\u4f75\u767c\u75c7\u5305\u62ec\u8102\u80aa\u6027\u809d\u75c5\u3001\u7cd6\u5c3f\u75c5\u524d\u671f\u3001\u8840\u8102\u7570\u5e38\u3001\u9ad8\u8840\u58d3\u548c\u9ad8\u5c3f\u9178\u8840\u75c7[i]\u3002\u5927\u91cf\u91ab\u5b78\u8b49\u64da\u8868\u660e\uff0c\u751f\u6d3b\u65b9\u5f0f\u7ba1\u7406\u7d50\u5408\u85e5\u7269\u6cbb\u7642\u4f86\u964d\u4f4e\u9ad4\u91cd\u53ef\u4ee5\u6539\u5584\u4ee3\u8b1d\u548c\u5fc3\u8840\u7ba1\u5371\u96aa\u56e0\u7d20\u5f9e\u800c\u6539\u5584\u5065\u5eb7\u7d50\u5c40\u3002GLORY-1\u662f\u5168\u65b0\u6e1b\u91cd\u6a5f\u5236\u7684GLP-1R\/GCGR\u96d9\u9776\u9ede\u6fc0\u52d5\u5291\u746a\u4ed5\u5ea6\u80bd\u7684\u9996\u500bIII\u671f\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76\uff0c\u5176\u7d50\u679c\u5728\u570b\u969b\u5b78\u8853\u6703\u8b70\u4e0a\u767c\u8868\uff0c\u518d\u4e00\u6b21\u78ba\u8b49\u4e86\u746a\u4ed5\u5ea6\u80bd\u512a\u7570\u7684\u6e1b\u91cd\u7642\u6548\u3001\u591a\u91cd\u7684\u4ee3\u8b1d\u7372\u76ca\u6539\u5584\u53ca\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u5728\u9ad4\u91cd\u7ba1\u7406\u4e4b\u5916\u4e5f\u6709\u671b\u5e36\u4f86\u76f8\u95dc\u4f75\u767c\u75c7\u554f\u984c\u6539\u5584\u3002\u5e0c\u671b\u5176\u6210\u529f\u4e0a\u5e02\uff0c\u65e9\u65e5\u9020\u798f\u4e2d\u570b\u6578\u4ee5\u5104\u8a08\u7684\u8d85\u91cd\u6216\u80a5\u80d6\u4eba\u7fa4\u3002\u300d<\/p>\n

\u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\u81e8\u5e8a\u526f\u7e3d\u88c1\u9322\u9433\u535a\u58eb\u8868\u793a\uff1a\u300c\u5f88\u9ad8\u8208GLORY-1\u7814\u7a76\u5728\u570b\u969b\u5b78\u8853\u821e\u53f0\u4eae\u76f8\uff0c\u4e5f\u5c55\u73fe\u4e86\u6211\u570b\u7814\u7a76\u8005\u7684\u5353\u8d8a\u7684\u79d1\u7814\u6c34\u5e73\u548c\u4fe1\u9054\u751f\u7269\u7d2e\u5be6\u7684\u7814\u767c\u80fd\u529b\u3002\u9996\u500bIII\u671f\u8a3b\u518a\u81e8\u5e8aGLORY-1\u7814\u7a76\u7d50\u679c\u5f37\u6709\u529b\u9a57\u8b49\u4e86\u746a\u4ed5\u5ea6\u80bd\u7684\u5275\u65b0\u4f5c\u7528\u6a5f\u5236\uff0c\u5728\u5b89\u5168\u6027\u826f\u597d\u7684\u524d\u63d0\u4e0b\uff0c\u6e1b\u91cd\u6548\u679c\u5f37\u52c1\uff0c\u5927\u5e45\u964d\u4f4e\u809d\u81df\u8102\u80aa\u542b\u91cf\uff0c\u964d\u4f4e\u4e86\u591a\u9805\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u98a8\u96aa\u6307\u6a19\u3002\u746a\u4ed5\u5ea6\u80bd\u5728\u7cd6\u5c3f\u75c5\u53d7\u8a66\u8005\u4e2d\u7684III\u671f\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u4e5f\u5c07\u65bc\u4eca\u5e74\u5b78\u8853\u5927\u6703\u4e0a\u9678\u7e8c\u62ab\u9732\u3002\u4fe1\u9054\u751f\u7269\u5c07\u6301\u7e8c\u6253\u9020\u5fc3\u8840\u7ba1\u53ca\u4ee3\u8b1d\u9818\u57df\u5275\u65b0\u4e00\u4ee3\u7522\u54c1\u7ba1\u7dda\uff0c\u4e0d\u65b7\u6eff\u8db3\u8001\u767e\u59d3\u5c0d\u65bc\u5e78\u798f\u751f\u6d3b\u7684\u7f8e\u597d\u8ffd\u6c42\uff0c\u670d\u52d9\u66f4\u591a\u75c5\u60a3\u3002\u300d<\/p>\n

\u95dc\u65bc\u80a5\u80d6\/\u8d85\u91cd<\/p>\n

\u80a5\u80d6\u662f\u4e00\u9805\u6210\u56e0\u8907\u96dc\u7684\u6162\u6027\u4ee3\u8b1d\u6027\u75be\u75c5\uff0c\u662f\u5c0e\u81f4\u7cd6\u5c3f\u75c5\u3001\u8102\u80aa\u809d\u3001\u5fc3\u8166\u8840\u7ba1\u75be\u75c5\u3001\u814e\u75c5\u3001\u95dc\u7bc0\u75be\u75c5\u3001\u547c\u5438\u7761\u7720\u969c\u7919\u548c\u764c\u75c7\u7b49\u4e00\u7cfb\u5217\u75be\u75c5\u7684\u91cd\u8981\u75c5\u56e0\u6216\u5371\u96aa\u56e0\u7d20\u3002\u96a8\u8457\u7d93\u6fdf\u767c\u5c55\u548c\u751f\u6d3b\u65b9\u5f0f\u7684\u6539\u8b8a\uff0c\u4e2d\u570b\u80a5\u80d6\u75c7\u7684\u60a3\u75c5\u4eba\u6578\u5df2\u8e8d\u5c45\u4e16\u754c\u9996\u4f4d[ii]\u3002\u5728\u8f03\u70ba\u56b4\u91cd\u7684\u80a5\u80d6\u60a3\u8005\u4e2d\uff0c\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u7cd6\u5c3f\u75c5\u548c\u67d0\u4e9b\u816b\u7624\u7684\u767c\u751f\u7387\u53ca\u6b7b\u4ea1\u7387\u660e\u986f\u4e0a\u5347\u30022019\u5e74\u8d85\u91cd\u548c\u80a5\u80d6\u5c0e\u81f4\u7684\u6b7b\u4ea1\u5728\u6162\u6027\u975e\u50b3\u67d3\u6027\u75be\u75c5\u76f8\u95dc\u6b7b\u4ea1\u4e2d\u5360\u6bd411.1%\uff0c\u76f8\u6bd41990\u5e74\u76845.7%\u986f\u8457\u589e\u52a0[iii]\u3002\u8d85\u91cd\/\u80a5\u80d6\u5df2\u6210\u70ba\u4e00\u500b\u56b4\u91cd\u7684\u5065\u5eb7\u554f\u984c\uff0c\u751f\u6d3b\u65b9\u5f0f\u5e72\u9810\u662f\u8d85\u91cd\/\u80a5\u80d6\u8005\u7684\u57fa\u790e\u4e14\u91cd\u8981\u624b\u6bb5\uff0c\u4f46\u662f\u4ecd\u6709\u76f8\u7576\u4e00\u90e8\u5206\u60a3\u8005\u7531\u65bc\u7a2e\u7a2e\u539f\u56e0\u4e0d\u80fd\u9054\u5230\u671f\u671b\u7684\u6e1b\u91cd\u76ee\u6a19\uff0c\u9700\u7528\u85e5\u7269\u8f14\u52a9\u6cbb\u7642\u3002\u50b3\u7d71\u6e1b\u80a5\u85e5\u6e1b\u91cd\u6548\u679c\u6709\u9650\uff0c\u4e14\u5b58\u5728\u5b89\u5168\u6027\u554f\u984c\uff0c\u5c0d\u7642\u6548\u66f4\u597d\u4e14\u5b89\u5168\u7684\u6e1b\u80a5\u7642\u6cd5\u7684\u81e8\u5e8a\u9700\u6c42\u5c1a\u672a\u5f97\u5230\u6eff\u8db3\u3002<\/p>\n

\u95dc\u65bc\u746a\u4ed5\u5ea6\u80bd\uff08IBI362\uff09<\/p>\n

\u746a\u4ed5\u5ea6\u80bd\uff08IBI362\uff09\u662f\u4fe1\u9054\u751f\u7269\u8207\u79ae\u4f86\u88fd\u85e5\u5171\u540c\u63a8\u9032\u7684\u4e00\u6b3e\u80f0\u9ad8\u8840\u7cd6\u7d20\u6a23\u80bd-1\u53d7\u9ad4\uff08GLP-1R\uff09\/\u80f0\u9ad8\u8840\u7cd6\u7d20\u53d7\u9ad4\uff08GCGR\uff09\u96d9\u91cd\u6fc0\u52d5\u5291\u3002\u4f5c\u70ba\u4e00\u7a2e\u4eba\u9ad4\u5167\u5929\u7136\u5b58\u5728\u7684\u80c3\u6ccc\u9178\u8abf\u7bc0\u7d20\uff08OXM\uff09\u985e\u4f3c\u7269\uff0c\u746a\u4ed5\u5ea6\u80bd\u9664\u4e86\u901a\u904e\u6fc0\u52d5GLP-1R\u4fc3\u9032\u80f0\u5cf6\u7d20\u5206\u6ccc\u3001\u964d\u4f4e\u8840\u7cd6\u548c\u6e1b\u8f15\u9ad4\u91cd\u5916\uff0c\u9084\u53ef\u901a\u904e\u6fc0\u52d5GCGR\u589e\u52a0\u80fd\u91cf\u6d88\u8017\u589e\u5f37\u6e1b\u91cd\u7642\u6548\uff0c\u540c\u6642\u6539\u5584\u809d\u81df\u8102\u80aa\u4ee3\u8b1d\u3002\u746a\u4ed5\u5ea6\u80bd\u5df2\u5728\u591a\u9805\u81e8\u5e8a\u7814\u7a76\u4e2d\u5c55\u73fe\u51fa\u512a\u79c0\u7684\u6e1b\u91cd\u548c\u964d\u7cd6\u7642\u6548\uff0c\u4ee5\u53ca\u964d\u4f4e\u8170\u570d\u3001\u8840\u8102\u3001\u8840\u58d3\u3001\u8840\u5c3f\u9178\u3001\u809d\u9176\u53ca\u809d\u81df\u8102\u80aa\u542b\u91cf\uff0c\u4ee5\u53ca\u6539\u5584\u80f0\u5cf6\u7d20\u654f\u611f\u6027\uff0c\u5e36\u4f86\u591a\u91cd\u4ee3\u8b1d\u7372\u76ca\u3002\u76ee\u524d\uff0c\u746a\u4ed5\u5ea6\u80bd\u5728\u4e2d\u570b\u8d85\u91cd\u6216\u80a5\u80d6\uff08GLORY-1\u548cGLORY-2\uff09\u53d7\u8a66\u8005\u548c2\u578b\u7cd6\u5c3f\u75c5\uff08DREAMS-1\uff0cDREAMS-2\u548cDREAMS-3\uff09\u53d7\u8a66\u8005\u4e2d\u7684\u4e94\u9805III\u671f\u81e8\u5e8a\u7814\u7a76\u6b63\u5728\u9032\u884c\u4e2d\u3002 \u5176\u4e2d\uff0c GLORY-1\u548cDREAMS-2\u7814\u7a76\u5df2\u7d93\u9054\u6210\u4e3b\u8981\u7d42\u9ede\u3002<\/p>\n

2024\u5e742\u6708\uff0c\u746a\u4ed5\u5ea6\u80bd\u7684\u9996\u500bNDA\u7372NMPA\u53d7\u7406\uff0c\u7528\u65bc\u6210\u4eba\u80a5\u80d6\u6216\u8d85\u91cd\u60a3\u8005\u7684\u9577\u671f\u9ad4\u91cd\u63a7\u5236\u3002<\/p>\n

\u95dc\u65bc\u4fe1\u9054\u751f\u7269<\/p>\n

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\u8a73\u60c5\u8acb\u8a2a\u554f\u516c\u53f8\u7db2\u7ad9\uff1awww.innoventbio.com<\/a>\u6216\u516c\u53f8\u9818\u82f1\u8cec\u865fInnovent Biologics\u3002<\/p>\n

\u8072\u660e\uff1a\u4fe1\u9054\u4e0d\u63a8\u85a6\u4efb\u4f55\u672a\u7372\u6279\u7684\u85e5\u54c1\/\u9069\u61c9\u75c7\u4f7f\u7528\u3002<\/p>\n

\u524d\u77bb\u6027\u8072\u660e<\/p>\n

\u672c\u65b0\u805e\u7a3f\u6240\u767c\u4f48\u7684\u4fe1\u606f\u4e2d\u53ef\u80fd\u6703\u5305\u542b\u67d0\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u3002\u9019\u4e9b\u8868\u8ff0\u672c\u8cea\u4e0a\u5177\u6709\u76f8\u7576\u98a8\u96aa\u548c\u4e0d\u78ba\u5b9a\u6027\u3002\u5728\u4f7f\u7528\u300c\u9810\u671f\u300d\u3001\u300c\u76f8\u4fe1\u300d\u3001\u300c\u9810\u6e2c\u300d\u3001\u300c\u671f\u671b\u300d\u3001\u300c\u6253\u7b97\u300d\u53ca\u5176\u4ed6\u985e\u4f3c\u8a5e\u8a9e\u9032\u884c\u8868\u8ff0\u6642\uff0c\u51e1\u8207\u672c\u516c\u53f8\u6709\u95dc\u7684\uff0c\u76ee\u7684\u5747\u662f\u8981\u6307\u660e\u5176\u5c6c\u524d\u77bb\u6027\u8868\u8ff0\u3002\u672c\u516c\u53f8\u4e26\u7121\u7fa9\u52d9\u4e0d\u65b7\u5730\u66f4\u65b0\u9019\u4e9b\u9810\u6e2c\u6027\u9673\u8ff0\u3002<\/p>\n

\u9019\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u4e43\u57fa\u65bc\u672c\u516c\u53f8\u7ba1\u7406\u5c64\u5728\u505a\u51fa\u8868\u8ff0\u6642\u5c0d\u672a\u4f86\u4e8b\u52d9\u7684\u73fe\u6709\u770b\u6cd5\u3001\u5047\u8a2d\u3001\u671f\u671b\u3001\u4f30\u8a08\u3001\u9810\u6e2c\u548c\u7406\u89e3\u3002\u9019\u4e9b\u8868\u8ff0\u4e26\u975e\u5c0d\u672a\u4f86\u767c\u5c55\u7684\u4fdd\u8b49\uff0c\u6703\u53d7\u5230\u98a8\u96aa\u3001\u4e0d\u78ba\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u97ff\uff0c\u6709\u4e9b\u4e43\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u7bc4\u570d\uff0c\u96e3\u4ee5\u9810\u8a08\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u5011\u7684\u696d\u52d9\u3001\u7af6\u722d\u74b0\u5883\u3001\u653f\u6cbb\u3001\u7d93\u6fdf\u3001\u6cd5\u5f8b\u548c\u793e\u6703\u60c5\u6cc1\u7684\u672a\u4f86\u8b8a\u5316\u53ca\u767c\u5c55\u7684\u5f71\u97ff\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u6703\u8207\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8cc7\u6599\u6709\u8f03\u5927\u5dee\u5225\u3002<\/p>\n

\u53c3\u8003\u6587\u737b<\/p>\n

[i] Chen K, Shen Z, Gu W, Lyu Z, Qi X, Mu Y, Ning Y; Meinian Investigator Group. Prevalence of obesity and associated complications in China<\/span>: A cross-sectional, real-world study in 15.8 million adults. Diabetes Obes Metab. 2023 Aug 17. doi: 10.1111\/dom.15238. Epub ahead of print. PMID: 37589256.<\/p>\n

[ii]\u00a0Pan XF, Wang L, Pan A. Epidemiology and determinants of obesity in China<\/span>. Lancet Diabetes Endocrinol 2021; 9: 373-92.<\/p>\n

[iii]\u00a0Institute for Health Metrics and Evaluation. Global Health Data Exchange. GBD results tool. http:\/\/ghdx.healthdata.org\/gbd-resultstool<\/a> (accessed Jan 10, 2021<\/span>).<\/p>\n

\u00a0<\/p>","protected":false},"excerpt":{"rendered":"

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kg\/m2\uff09\u53d7\u8a66\u8005\u4e2d\u8a55\u4f30\u746a\u4ed5\u5ea6\u80bd\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u7684\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\u3002\u5171\u5165\u7d44610\u4f8b\u53d7\u8a66\u8005\uff0c\u63091\uff1a1\uff1a1\u96a8\u6a5f\u5206\u914d\u81f3\u746a\u4ed5\u5ea6\u80bd4 mg\u7d44\uff08N=203\uff09\u3001\u746a\u4ed5\u5ea6\u80bd6 mg\u7d44\uff08N=202\uff09\u6216\u5b89\u6170\u5291\u7d44\uff08N=205\uff09\uff0c\u6cbb\u764248\u5468\u3002 \u746a\u4ed5\u5ea6\u80bd\u7684\u6e1b\u91cd\u7642\u6548\u986f\u8457\u512a\u65bc\u5b89\u6170\u5291\u7d44 \u5728\u7b2c32\u5468\u548c48\u5468\u6642\u9ad4\u91cd\u8f03\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316\uff0c\u4ee5\u53ca\u9ad4\u91cd\u8f03\u57fa\u7dda\u964d\u5e45\u22655%\uff0c\u226510%\u548c\u226515%\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u4e0a\uff0c\u746a\u4ed5\u5ea6\u80bd4 mg\u548c6 mg\u5747\u512a\u65bc\u5b89\u6170\u5291\uff08P<0.001\uff09\uff1b\u5176\u4e2d\uff0c\u5728\u7642\u6cd5\u4f30\u8a08\u76ee\u6a19\u548c\u7642\u6548\u4f30\u8a08\u76ee\u6a19\u4e0b\uff0c\u7b2c48\u5468\u6642\u746a\u4ed5\u5ea6\u80bd6mg\u7d44\u76f8\u8f03\u5b89\u6170\u5291\u7d44\u7684\u5dee\u503c\u5206\u5225\u70ba14.31%\u548c14.37%\u3002\u8a73\u7d30\u7d50\u679c\u898b\u4e0b\u8868\uff1a \u7642\u6cd5\u4f30\u8a08\u76ee\u6a19* \u7642\u6548\u4f30\u8a08\u76ee\u6a19\u2020 \u746a\u4ed5\u5ea6\u80bd\u00a04 mg (N=203) \u746a\u4ed5\u5ea6\u80bd\u00a06 mg (N=202) \u5b89\u6170\u5291 \u00a0(N=205) \u746a\u4ed5\u5ea6\u80bd\u00a04 mg (N=203) \u746a\u4ed5\u5ea6\u80bd\u00a06 mg (N=202) \u5b89\u6170\u5291\u00a0(N=205) \u9996\u8981\u7d42\u9ede\u00b6 \u7b2c32\u5468\u6642\u9ad4\u91cd\u8f03\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316, % \u221210.09 \u221212.55 0.45 \u221210.97 \u221213.38 \u22120.24 \u8207\u5b89\u6170\u5291\u7d44\u7684\u5dee\u7570\u00a0(97.5% CI) \u221210.54 \u00a0(\u221212.01, \u22129.08) \u221213.00 (\u221214.49,\u221211.51) \u221210.72 \u00a0(\u221212.21,\u22129.23) \u221213.14 (\u221214.64,\u221211.64) \u7b2c32\u5468\u6642\u9ad4\u91cd\u8f03\u57fa\u7dda\u964d\u5e45\u22655% \u7684\u53d7\u8a66\u8005\u6bd4\u4f8b, %\u00a7 73.9 82.0 10.5 76.3 84.0 10.9 \u9ad4\u91cd\u95dc\u9375\u6b21\u8981\u7d42\u9ede\u00b6 \u7b2c48\u5468\u6642\u9ad4\u91cd\u8f03\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316, % \u221211.00 \u221214.01 0.30 \u221212.05 \u221214.84 \u22120.47 \u8207\u5b89\u6170\u5291\u7d44\u7684\u5dee\u7570\u00a0(97.5% CI) \u221211.30 (\u221213.06, \u22129.54) \u221214.31 (\u221216.11,\u221212.51) \u221211.58 (\u221213.38, \u22129.79) \u221214.37 (\u221216.18,\u221212.56) \u7b2c48\u5468\u6642\u9ad4\u91cd\u8f03\u57fa\u7dda\u964d\u5e45\u22655% \u7684\u53d7\u8a66\u8005\u6bd4\u4f8b, %\u00a7 71.6 81.6 10.8 73.5 82.8 11.5 \u7b2c48\u5468\u6642\u9ad4\u91cd\u8f03\u57fa\u7dda\u964d\u5e45\u226510% \u7684\u53d7\u8a66\u8005\u6bd4\u4f8b, %\u00a7 53.5 66.7 2.6 55.2 67.9 2.9 \u7b2c48\u5468\u6642\u9ad4\u91cd\u8f03\u57fa\u7dda\u964d\u5e45\u226515% \u7684\u53d7\u8a66\u8005\u6bd4\u4f8b, %\u00a7 35.7 49.5 2.0 37.0 50.6 2.1 \u8f03\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316\u548c\u8b8a\u5316\u503c\u70ba\u6700\u5c0f\u4e8c\u4e58\u5747\u503c\u3002\u8207\u5b89\u6170\u5291\u7d44\u7684\u5dee\u7570\u70ba\u6700\u5c0f\u4e8c\u4e58\u5747\u503c\uff08\u7f6e\u4fe1\u5340\u9593\uff09\u3002 * \u7642\u6cd5\u4f30\u8a08\u76ee\u6a19\u4ee3\u8868\u7121\u8ad6\u662f\u5426\u4f9d\u5f9e\u65b9\u6848\u5b8c\u6210\u7814\u7a76\u85e5\u7269\u6cbb\u7642\uff0c\u746a\u4ed5\u5ea6\u80bd\u76f8\u5c0d\u5b89\u6170\u5291\u7684\u7642\u6548\u3002\u5728\u7642\u6cd5\u4f30\u8a08\u76ee\u6a19\u4e2d\uff0c\u9023\u7e8c\u8b8a\u91cf\u7d42\u9ede\u4f7f\u7528\u5354\u65b9\u5dee\u5206\u6790\uff08ANCOVA\uff09\uff0c\u5206\u985e\u8b8a\u91cf\u4f7f\u7528\u56de\u6b78\u5206\u6790\u3002\u00a0 \u2020 \u7642\u6548\u4f30\u8a08\u76ee\u6a19\u4ee3\u8868\u5982\u679c\u4f9d\u5f9e\u65b9\u6848\u5b8c\u6210\u746a\u4ed5\u5ea6\u80bd\u5168\u7a0b\u6cbb\u7642\uff0c\u746a\u4ed5\u5ea6\u80bd\u76f8\u5c0d\u5b89\u6170\u5291\u7684\u7642\u6548\u3002\u5728\u7642\u6cd5\u4f30\u8a08\u76ee\u6a19\u4e2d\uff0c\u9023\u7e8c\u8b8a\u91cf\u7d42\u9ede\u4f7f\u7528\u91cd\u8907\u6e2c\u91cf\u7684\u6df7\u5408\u6548\u61c9\u6a21\u578b\uff08MMRM\uff09\uff0c\u5206\u985e\u8b8a\u91cf\u4f7f\u7528\u56de\u6b78\u5206\u6790\u3002 \u00a7 \u586b\u88dc\u5f8c\u61c9\u7b54\u7387\u3002\u00a0 \u00b6 P<0.0001\uff08\u96d9\u5074\uff09\uff0c\u512a\u6548\u65bc\u5b89\u6170\u5291, \u63a7\u5236I\u985e\u932f\u8aa4\u3002\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u00a0\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u746a\u4ed5\u5ea6\u80bd\u986f\u8457\u964d\u4f4e\u591a\u500b\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u98a8\u96aa\u6307\u6a19 \u5728\u7b2c48\u5468\u6642\uff0c\u8170\u570d\u3001\u6536\u7e2e\u58d3\u3001\u7518\u6cb9\u4e09\u916f\u3001\u7e3d\u81bd\u56fa\u9187\u3001LDL-C\u3001\u8840\u5c3f\u9178\u548cALT\u8f03\u57fa\u7dda\u7684\u8b8a\u5316\u4e0a\uff0c\u746a\u4ed5\u5ea6\u80bd\u5747\u512a\u65bc\u5b89\u6170\u5291\uff08P<0.001\uff09\u3002 \u7642\u6548\u4f30\u8a08\u76ee\u6a19\u4e0b\uff0c\u7b2c48\u5468\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd4mg\uff0c\u746a\u4ed5\u5ea6\u80bd6mg\u548c\u5b89\u6170\u5291\u7d44\u8170\u570d\u8f03\u57fa\u7dda\u5206\u5225\u4e0b\u964d\u22129.48 cm, \u221210.96 cm \u548c \u22121.48 cm; \u746a\u4ed5\u5ea6\u80bd\u5408\u8a08\u7d44\uff084mg \u548c 6mg\uff09\u76f8\u8f03\u5b89\u6170\u5291\u7d44\u4e5f\u986f\u8457\u964d\u4f4e\u6536\u7e2e\u58d3\uff08\u22129.21 mmHg vs. \u22122.46 mmHg\uff09\u3001\u7518\u6cb9\u4e09\u916f\uff08\u22120.68 mmol\/L vs. -0.16 mmol\/L\uff09\u3001\u7e3d\u81bd\u56fa\u9187\uff08-0.32 mmol\/L vs. 0.13 mmol\/L\uff09\u3001LDL-C\uff08-0.22 mmol\/L vs. 0.09 mmol\/L\uff09\u3001\u8840\u5c3f\u9178\uff08\u221244.79 \u03bcmol\/L vs. 5.96 \u03bcmol\/L\uff09\u548cALT\uff08\u221214.50 U\/L vs.-4.50 U\/L\uff09\u3002 \u746a\u4ed5\u5ea6\u80bd\u5927\u5e45\u5ea6\u964d\u4f4e\u809d\u81df\u8102\u80aa\u542b\u91cf \u5728GLORY-1\u7684\u63a2\u7d22\u6027\u5206\u6790\u4e2d\uff0c\u5c0d\u57fa\u7dda\u809d\u81df\u8102\u80aa\u542b\u91cf\uff08MRI-PDFF\uff09\u226510%\u7684\u53d7\u8a66\u8005\uff0c\u746a\u4ed5\u5ea6\u80bd6 mg\u7d44\u53d7\u8a66\u8005\u6cbb\u764248\u5468\u5f8c\uff0c\u809d\u81df\u8102\u80aa\u542b\u91cf\u8f03\u57fa\u7dda\u5e73\u5747\u4e0b\u964d\u905480.2%\uff0c\u5b89\u6170\u5291\u7d44\u4e0b\u964d5.3%\u3002[\u8a73\u898b\u5831\u9053] \u8010\u53d7\u6027\u548c\u5b89\u5168\u6027\u826f\u597d\uff0c\u7121\u65b0\u589e\u5b89\u5168\u6027\u4fe1\u865f \u746a\u4ed5\u5ea6\u80bd\u7684\u8010\u53d7\u6027\u826f\u597d\uff0c\u746a\u4ed5\u5ea6\u80bd4 mg\u548c6 mg\u7d44\u56e0\u4e0d\u826f\u4e8b\u4ef6\u5c0e\u81f4\u7814\u7a76\u85e5\u7269\u505c\u7528\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u5206\u52251.5%\u548c0.5%\uff0c\u5b89\u6170\u5291\u7d44\u70ba1.0%\u3002 \u746a\u4ed5\u5ea6\u80bd\u7684\u6574\u9ad4\u5b89\u5168\u6027\u7279\u5fb5\u8207\u746a\u4ed5\u5ea6\u80bd\u7684\u65e2\u5f80\u81e8\u5e8a\u7814\u7a76\u4ee5\u53caGLP-1R\u6fc0\u52d5\u5291\u985e\u85e5\u7269\u76f8\u4f3c\uff0c\u672a\u767c\u73fe\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002\u80c3\u8178\u9053\u75c7\u72c0\uff08\u5641\u5fc3\u3001\u8179\u7009\u548c\u5614\u5410\uff09\u662f\u6700\u5e38\u767c\u751f\u7684\u4e0d\u826f\u4e8b\u4ef6\uff0c\u7d55\u5927\u591a\u6578\u70ba\u8f15\u5ea6\u6216\u4e2d\u5ea6\uff0c\u4e14\u5927\u90e8\u5206\u767c\u751f\u65bc\u6ef4\u5b9a\u671f\u3002 \u746a\u4ed5\u5ea6\u80bd\u7d44\u7684\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\u767c\u751f\u7387\u4f4e\uff0c\u8207\u5b89\u6170\u5291\u7d44\u76f8\u7576\u3002 48\u5468\u6cbb\u7642\u671f\u9593\uff0c\u746a\u4ed5\u5ea6\u80bd4 mg\u548c6 mg\u7d44\u5fc3\u7387\u8f03\u57fa\u7dda\u7684\u8b8a\u5316\u5747\u503c\u672a\u8d85\u904e5\u6b21\/\u5206\u3002\u7b2c48\u5468\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd4 mg\u548c6 mg\u7d44\u7684\u5fc3\u7387\u8f03\u57fa\u7dda\u8b8a\u5316\u5747\u503c\u5747\u70ba1.6\u6b21\/\u5206\u3002\u7814\u7a76\u671f\u9593\u672a\u898b\u5fc3\u8840\u7ba1\u98a8\u96aa\u589e\u52a0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002 \u8a72\u7814\u7a76\u7684\u727d\u982d\u7814\u7a76\u8005\u3001\u5317\u4eac\u5927\u5b78\u4eba\u6c11\u91ab\u9662\u7d00\u7acb\u8fb2\u6559\u6388\u8868\u793a\uff1a\u300c\u8d85\u91cd\u548c\u80a5\u80d6\u662f\u591a\u7a2e\u4f75\u767c\u75c7\u7684\u5371\u96aa\u56e0\u7d20\uff0c\u5176\u4e2d\u6700\u5e38\u898b\u7684\u4f75\u767c\u75c7\u5305\u62ec\u8102\u80aa\u6027\u809d\u75c5\u3001\u7cd6\u5c3f\u75c5\u524d\u671f\u3001\u8840\u8102\u7570\u5e38\u3001\u9ad8\u8840\u58d3\u548c\u9ad8\u5c3f\u9178\u8840\u75c7[i]\u3002\u5927\u91cf\u91ab\u5b78\u8b49\u64da\u8868\u660e\uff0c\u751f\u6d3b\u65b9\u5f0f\u7ba1\u7406\u7d50\u5408\u85e5\u7269\u6cbb\u7642\u4f86\u964d\u4f4e\u9ad4\u91cd\u53ef\u4ee5\u6539\u5584\u4ee3\u8b1d\u548c\u5fc3\u8840\u7ba1\u5371\u96aa\u56e0\u7d20\u5f9e\u800c\u6539\u5584\u5065\u5eb7\u7d50\u5c40\u3002GLORY-1\u662f\u5168\u65b0\u6e1b\u91cd\u6a5f\u5236\u7684GLP-1R\/GCGR\u96d9\u9776\u9ede\u6fc0\u52d5\u5291\u746a\u4ed5\u5ea6\u80bd\u7684\u9996\u500bIII\u671f\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76\uff0c\u5176\u7d50\u679c\u5728\u570b\u969b\u5b78\u8853\u6703\u8b70\u4e0a\u767c\u8868\uff0c\u518d\u4e00\u6b21\u78ba\u8b49\u4e86\u746a\u4ed5\u5ea6\u80bd\u512a\u7570\u7684\u6e1b\u91cd\u7642\u6548\u3001\u591a\u91cd\u7684\u4ee3\u8b1d\u7372\u76ca\u6539\u5584\u53ca\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u5728\u9ad4\u91cd\u7ba1\u7406\u4e4b\u5916\u4e5f\u6709\u671b\u5e36\u4f86\u76f8\u95dc\u4f75\u767c\u75c7\u554f\u984c\u6539\u5584\u3002\u5e0c\u671b\u5176\u6210\u529f\u4e0a\u5e02\uff0c\u65e9\u65e5\u9020\u798f\u4e2d\u570b\u6578\u4ee5\u5104\u8a08\u7684\u8d85\u91cd\u6216\u80a5\u80d6\u4eba\u7fa4\u3002\u300d 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\u53c3\u8003\u6587\u737b [i] Chen K, Shen Z, Gu W, Lyu Z, Qi X, Mu Y, Ning Y; Meinian Investigator Group. … <\/p>\n

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\u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u80a1\u7968\u4ee3\u78bc\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u53ca\u5fc3\u8840\u7ba1\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u5275\u65b0\u85e5\u7269\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\u5ba3\u4f48\uff1a\u80f0\u9ad8\u8840\u7cd6\u7d20\u6a23\u80bd-1\u53d7\u9ad4\uff08GLP-1R\uff09\/\u80f0\u9ad8\u8840\u7cd6\u7d20\u53d7\u9ad4\uff08GCGR\uff09\u96d9\u91cd\u6fc0\u52d5\u5291\u746a\u4ed5\u5ea6\u80bd\uff08\u7814\u767c\u4ee3\u865f\uff1aIBI362\uff09\u5728\u4e2d\u570b\u8d85\u91cd\u6216\u80a5\u80d6\u6210\u4eba\u53d7\u8a66\u8005\u4e2d\u7684\u9996\u500bIII\u671f\u81e8\u5e8a\u7814\u7a76\uff08GLORY-1\uff09\u7684\u4e3b\u8981\u7d50\u679c\u53ca\u809d\u81df\u8102\u80aa\u542b\u91cf\u63a2\u7d22\u6027\u7d42\u9ede\u7d50\u679c\u57282024\u5e74\u7f8e\u570b\u7cd6\u5c3f\u75c5\u5354\u6703\uff08ADA\uff09\u79d1\u5b78\u6703\u8b70\u4e0a\u5206\u5225\u4ee5\u91cd\u78c5\u9032\u5c55\u53e3\u982d\u5831\u544a\uff08ePoster Theater, 1856-LB\uff09\u548c\u91cd\u78c5\u9032\u5c55\u6458\u8981\uff081857-LB\uff09\u7684\u5f62\u5f0f\u767c\u8868\u3002 GLORY-1\u7684\u4e3b\u8981\u7d42\u9ede\u548c\u95dc\u9375\u6b21\u8981\u7d42\u9ede\u5747\u9806\u5229\u9054\u6210\uff0c\u518d\u6b21\u5370\u8b49\u4e86GLP-1R\/GCGR\u96d9\u91cd\u6fc0\u52d5\u5291\u7684\u7368\u7279\u512a\u52e2 \u746a\u4ed5\u5ea6\u80bd\u53ef\u540c\u6642\u6fc0\u52d5GLP-1R\u548cGCGR\u3002\u901a\u904e\u6fc0\u52d5GLP-1R\u6291\u5236\u98df\u617e\u548c\u5ef6\u7de9\u80c3\u6392\u7a7a\uff0c\u5f9e\u800c\u9054\u5230\u6e1b\u8f15\u9ad4\u91cd\u7684\u529f\u6548\uff1b\u540c\u6642\u901a\u904e\u6fc0\u52d5GCGR\u589e\u52a0\u80fd\u91cf\u6d88\u8017\uff0c\u589e\u5f37\u6e1b\u91cd\u7642\u6548\u3002\u7279\u5225\u662f\uff0c\u746a\u4ed5\u5ea6\u80bd\u9084\u80fd\u7368\u7279\u5730\u901a\u904e\u5c0d\u809d\u81dfGCGR\u7684\u6fc0\u6d3b\uff0c\u4fc3\u9032\u8102\u80aa\u9178\u6c27\u5316\u548c\u8102\u80aa\u5206\u89e3\uff0c\u6539\u5584\u809d\u81df\u8102\u80aa\u4ee3\u8b1d\u3002 GLORY-1\u7684\u7814\u7a76\u7d50\u679c\u4e0d\u50c5\u8b49\u660e\u4e86\u746a\u4ed5\u5ea6\u80bd\u512a\u7570\u7684\u6e1b\u91cd\u7642\u6548\uff0c\u4ee5\u53ca\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u540c\u6642\u9084\u89c0\u5bdf\u5230\u7368\u7279\u7684\u809d\u81df\u8102\u80aa\u542b\u91cf\u5927\u5e45\u4e0b\u964d\uff0c\u4ee5\u53ca\u591a\u500b\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u98a8\u96aa\u6307\u6a19\u7684\u6539\u5584\uff0c\u518d\u6b21\u5370\u8b49\u4e86GLP-1R\/GCGR\u96d9\u91cd\u6fc0\u52d5\u5291\u7684\u7368\u7279\u512a\u52e2\u3002\u746a\u4ed5\u5ea6\u80bd\u9996\u500b\u6e1b\u91cd\u9069\u61c9\u75c7\u7684\u4e0a\u5e02\u7533\u8acb\u6b63\u5728\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u7684\u5be9\u8a55\u904e\u7a0b\u4e2d\u3002\u746a\u4ed5\u5ea6\u80bd\u6709\u671b\u70ba\u4e2d\u570b\u80a5\u80d6\u53ca\u8d85\u91cd\u4eba\u7fa4\u63d0\u4f9b\u5b89\u5168\u5f37\u6548\u4e26\u5168\u9762\u6539\u5584\u4ee3\u8b1d\u7684\u9ad4\u91cd\u7ba1\u7406\u65b9\u6848\u3002 GLORY-1\u7684\u5b8c\u6574\u7d50\u679c\u5c07\u5728\u5b78\u8853\u671f\u520a\u767c\u8868\u3002\u746a\u4ed5\u5ea6\u80bd\u5728\u5df2\u958b\u5c55\u768417\u9805\u81e8\u5e8a\u7814\u7a76\u4e2d\u5df2\u7d2f\u8a08\u8d85\u904e1,500\u4eba\u7684\u66b4\u9732\u91cf\uff0c\u70ba\u4e2d\u570b\u80a5\u80d6\u548c\u7cd6\u5c3f\u75c5\u9632\u6cbb\u63d0\u4f9b\u4e86\u9ad8\u8cea\u91cf\u7684\u5faa\u8b49\u91ab\u5b78\u8b49\u64da\u3002 GLORY-1\uff08ClinicalTrial.gov\uff1aNCT05607680\uff09\u662f\u4e00\u9805\u5728\u4e2d\u570b\u8d85\u91cd\uff08BMI\u226524 kg\/m2\uff09\u4f34\u6709\u81f3\u5c11\u4e00\u7a2e\u9ad4\u91cd\u76f8\u95dc\u5408\u4f75\u75c7\u6216\u80a5\u80d6\uff08BMI\u226528 kg\/m2\uff09\u53d7\u8a66\u8005\u4e2d\u8a55\u4f30\u746a\u4ed5\u5ea6\u80bd\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u7684\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\u3002\u5171\u5165\u7d44610\u4f8b\u53d7\u8a66\u8005\uff0c\u63091\uff1a1\uff1a1\u96a8\u6a5f\u5206\u914d\u81f3\u746a\u4ed5\u5ea6\u80bd4 mg\u7d44\uff08N=203\uff09\u3001\u746a\u4ed5\u5ea6\u80bd6 mg\u7d44\uff08N=202\uff09\u6216\u5b89\u6170\u5291\u7d44\uff08N=205\uff09\uff0c\u6cbb\u764248\u5468\u3002 \u746a\u4ed5\u5ea6\u80bd\u7684\u6e1b\u91cd\u7642\u6548\u986f\u8457\u512a\u65bc\u5b89\u6170\u5291\u7d44 \u5728\u7b2c32\u5468\u548c48\u5468\u6642\u9ad4\u91cd\u8f03\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316\uff0c\u4ee5\u53ca\u9ad4\u91cd\u8f03\u57fa\u7dda\u964d\u5e45\u22655%\uff0c\u226510%\u548c\u226515%\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u4e0a\uff0c\u746a\u4ed5\u5ea6\u80bd4 mg\u548c6 mg\u5747\u512a\u65bc\u5b89\u6170\u5291\uff08P<0.001\uff09\uff1b\u5176\u4e2d\uff0c\u5728\u7642\u6cd5\u4f30\u8a08\u76ee\u6a19\u548c\u7642\u6548\u4f30\u8a08\u76ee\u6a19\u4e0b\uff0c\u7b2c48\u5468\u6642\u746a\u4ed5\u5ea6\u80bd6mg\u7d44\u76f8\u8f03\u5b89\u6170\u5291\u7d44\u7684\u5dee\u503c\u5206\u5225\u70ba14.31%\u548c14.37%\u3002\u8a73\u7d30\u7d50\u679c\u898b\u4e0b\u8868\uff1a \u7642\u6cd5\u4f30\u8a08\u76ee\u6a19* \u7642\u6548\u4f30\u8a08\u76ee\u6a19\u2020 \u746a\u4ed5\u5ea6\u80bd\u00a04 mg (N=203) \u746a\u4ed5\u5ea6\u80bd\u00a06 mg (N=202) \u5b89\u6170\u5291 \u00a0(N=205) \u746a\u4ed5\u5ea6\u80bd\u00a04 mg (N=203) \u746a\u4ed5\u5ea6\u80bd\u00a06 mg (N=202) \u5b89\u6170\u5291\u00a0(N=205) \u9996\u8981\u7d42\u9ede\u00b6 \u7b2c32\u5468\u6642\u9ad4\u91cd\u8f03\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316, % \u221210.09 \u221212.55 0.45 \u221210.97 \u221213.38 \u22120.24 \u8207\u5b89\u6170\u5291\u7d44\u7684\u5dee\u7570\u00a0(97.5% CI) \u221210.54 \u00a0(\u221212.01, \u22129.08) \u221213.00 (\u221214.49,\u221211.51) \u221210.72 \u00a0(\u221212.21,\u22129.23) \u221213.14 (\u221214.64,\u221211.64) \u7b2c32\u5468\u6642\u9ad4\u91cd\u8f03\u57fa\u7dda\u964d\u5e45\u22655% \u7684\u53d7\u8a66\u8005\u6bd4\u4f8b, %\u00a7 73.9 82.0 10.5 76.3 84.0 10.9 \u9ad4\u91cd\u95dc\u9375\u6b21\u8981\u7d42\u9ede\u00b6 \u7b2c48\u5468\u6642\u9ad4\u91cd\u8f03\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316, % \u221211.00 \u221214.01 0.30 \u221212.05 \u221214.84 \u22120.47 \u8207\u5b89\u6170\u5291\u7d44\u7684\u5dee\u7570\u00a0(97.5% CI) \u221211.30 (\u221213.06, \u22129.54) \u221214.31 (\u221216.11,\u221212.51) \u221211.58 (\u221213.38, \u22129.79) \u221214.37 (\u221216.18,\u221212.56) \u7b2c48\u5468\u6642\u9ad4\u91cd\u8f03\u57fa\u7dda\u964d\u5e45\u22655% \u7684\u53d7\u8a66\u8005\u6bd4\u4f8b, %\u00a7 71.6 81.6 10.8 73.5 82.8 11.5 \u7b2c48\u5468\u6642\u9ad4\u91cd\u8f03\u57fa\u7dda\u964d\u5e45\u226510% \u7684\u53d7\u8a66\u8005\u6bd4\u4f8b, %\u00a7 53.5 66.7 2.6 55.2 67.9 2.9 \u7b2c48\u5468\u6642\u9ad4\u91cd\u8f03\u57fa\u7dda\u964d\u5e45\u226515% \u7684\u53d7\u8a66\u8005\u6bd4\u4f8b, %\u00a7 35.7 49.5 2.0 37.0 50.6 2.1 \u8f03\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316\u548c\u8b8a\u5316\u503c\u70ba\u6700\u5c0f\u4e8c\u4e58\u5747\u503c\u3002\u8207\u5b89\u6170\u5291\u7d44\u7684\u5dee\u7570\u70ba\u6700\u5c0f\u4e8c\u4e58\u5747\u503c\uff08\u7f6e\u4fe1\u5340\u9593\uff09\u3002 * \u7642\u6cd5\u4f30\u8a08\u76ee\u6a19\u4ee3\u8868\u7121\u8ad6\u662f\u5426\u4f9d\u5f9e\u65b9\u6848\u5b8c\u6210\u7814\u7a76\u85e5\u7269\u6cbb\u7642\uff0c\u746a\u4ed5\u5ea6\u80bd\u76f8\u5c0d\u5b89\u6170\u5291\u7684\u7642\u6548\u3002\u5728\u7642\u6cd5\u4f30\u8a08\u76ee\u6a19\u4e2d\uff0c\u9023\u7e8c\u8b8a\u91cf\u7d42\u9ede\u4f7f\u7528\u5354\u65b9\u5dee\u5206\u6790\uff08ANCOVA\uff09\uff0c\u5206\u985e\u8b8a\u91cf\u4f7f\u7528\u56de\u6b78\u5206\u6790\u3002\u00a0 \u2020 \u7642\u6548\u4f30\u8a08\u76ee\u6a19\u4ee3\u8868\u5982\u679c\u4f9d\u5f9e\u65b9\u6848\u5b8c\u6210\u746a\u4ed5\u5ea6\u80bd\u5168\u7a0b\u6cbb\u7642\uff0c\u746a\u4ed5\u5ea6\u80bd\u76f8\u5c0d\u5b89\u6170\u5291\u7684\u7642\u6548\u3002\u5728\u7642\u6cd5\u4f30\u8a08\u76ee\u6a19\u4e2d\uff0c\u9023\u7e8c\u8b8a\u91cf\u7d42\u9ede\u4f7f\u7528\u91cd\u8907\u6e2c\u91cf\u7684\u6df7\u5408\u6548\u61c9\u6a21\u578b\uff08MMRM\uff09\uff0c\u5206\u985e\u8b8a\u91cf\u4f7f\u7528\u56de\u6b78\u5206\u6790\u3002 \u00a7 \u586b\u88dc\u5f8c\u61c9\u7b54\u7387\u3002\u00a0 \u00b6 P<0.0001\uff08\u96d9\u5074\uff09\uff0c\u512a\u6548\u65bc\u5b89\u6170\u5291, \u63a7\u5236I\u985e\u932f\u8aa4\u3002\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u00a0\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u746a\u4ed5\u5ea6\u80bd\u986f\u8457\u964d\u4f4e\u591a\u500b\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u98a8\u96aa\u6307\u6a19 \u5728\u7b2c48\u5468\u6642\uff0c\u8170\u570d\u3001\u6536\u7e2e\u58d3\u3001\u7518\u6cb9\u4e09\u916f\u3001\u7e3d\u81bd\u56fa\u9187\u3001LDL-C\u3001\u8840\u5c3f\u9178\u548cALT\u8f03\u57fa\u7dda\u7684\u8b8a\u5316\u4e0a\uff0c\u746a\u4ed5\u5ea6\u80bd\u5747\u512a\u65bc\u5b89\u6170\u5291\uff08P<0.001\uff09\u3002 \u7642\u6548\u4f30\u8a08\u76ee\u6a19\u4e0b\uff0c\u7b2c48\u5468\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd4mg\uff0c\u746a\u4ed5\u5ea6\u80bd6mg\u548c\u5b89\u6170\u5291\u7d44\u8170\u570d\u8f03\u57fa\u7dda\u5206\u5225\u4e0b\u964d\u22129.48 cm, \u221210.96 cm \u548c \u22121.48 cm; \u746a\u4ed5\u5ea6\u80bd\u5408\u8a08\u7d44\uff084mg \u548c 6mg\uff09\u76f8\u8f03\u5b89\u6170\u5291\u7d44\u4e5f\u986f\u8457\u964d\u4f4e\u6536\u7e2e\u58d3\uff08\u22129.21 mmHg vs. \u22122.46 mmHg\uff09\u3001\u7518\u6cb9\u4e09\u916f\uff08\u22120.68 mmol\/L vs. -0.16 mmol\/L\uff09\u3001\u7e3d\u81bd\u56fa\u9187\uff08-0.32 mmol\/L vs. 0.13 mmol\/L\uff09\u3001LDL-C\uff08-0.22 mmol\/L vs. 0.09 mmol\/L\uff09\u3001\u8840\u5c3f\u9178\uff08\u221244.79 \u03bcmol\/L vs. 5.96 \u03bcmol\/L\uff09\u548cALT\uff08\u221214.50 U\/L vs.-4.50 U\/L\uff09\u3002 \u746a\u4ed5\u5ea6\u80bd\u5927\u5e45\u5ea6\u964d\u4f4e\u809d\u81df\u8102\u80aa\u542b\u91cf \u5728GLORY-1\u7684\u63a2\u7d22\u6027\u5206\u6790\u4e2d\uff0c\u5c0d\u57fa\u7dda\u809d\u81df\u8102\u80aa\u542b\u91cf\uff08MRI-PDFF\uff09\u226510%\u7684\u53d7\u8a66\u8005\uff0c\u746a\u4ed5\u5ea6\u80bd6 mg\u7d44\u53d7\u8a66\u8005\u6cbb\u764248\u5468\u5f8c\uff0c\u809d\u81df\u8102\u80aa\u542b\u91cf\u8f03\u57fa\u7dda\u5e73\u5747\u4e0b\u964d\u905480.2%\uff0c\u5b89\u6170\u5291\u7d44\u4e0b\u964d5.3%\u3002[\u8a73\u898b\u5831\u9053] \u8010\u53d7\u6027\u548c\u5b89\u5168\u6027\u826f\u597d\uff0c\u7121\u65b0\u589e\u5b89\u5168\u6027\u4fe1\u865f \u746a\u4ed5\u5ea6\u80bd\u7684\u8010\u53d7\u6027\u826f\u597d\uff0c\u746a\u4ed5\u5ea6\u80bd4 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\u53c3\u8003\u6587\u737b [i] Chen K, Shen Z, Gu W, Lyu Z, Qi X, Mu Y, Ning Y; Meinian Investigator Group. ... \u4e86\u89e3\u8a73\u60c5\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.franchise.com.hk\/en\/%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%9c%a82024%e5%b9%b4%e7%be%8e%e5%9c%8b%e7%b3%96%e5%b0%bf%e7%97%85%e5%8d%94%e6%9c%83%ef%bc%88ada%ef%bc%89%e7%a7%91%e5%ad%b8%e6%9c%83%e8%ad%b0%e5%85%ac%e4%bd%88glp\/19961\" \/>\n<meta property=\"og:site_name\" content=\"\u9999\u6e2f\u7279\u8a31\u7d93\u71df\" \/>\n<meta property=\"article:published_time\" content=\"2024-06-24T16:12:00+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" 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mg\u5747\u512a\u65bc\u5b89\u6170\u5291\uff08P<0.001\uff09\uff1b\u5176\u4e2d\uff0c\u5728\u7642\u6cd5\u4f30\u8a08\u76ee\u6a19\u548c\u7642\u6548\u4f30\u8a08\u76ee\u6a19\u4e0b\uff0c\u7b2c48\u5468\u6642\u746a\u4ed5\u5ea6\u80bd6mg\u7d44\u76f8\u8f03\u5b89\u6170\u5291\u7d44\u7684\u5dee\u503c\u5206\u5225\u70ba14.31%\u548c14.37%\u3002\u8a73\u7d30\u7d50\u679c\u898b\u4e0b\u8868\uff1a \u7642\u6cd5\u4f30\u8a08\u76ee\u6a19* \u7642\u6548\u4f30\u8a08\u76ee\u6a19\u2020 \u746a\u4ed5\u5ea6\u80bd\u00a04 mg (N=203) \u746a\u4ed5\u5ea6\u80bd\u00a06 mg (N=202) \u5b89\u6170\u5291 \u00a0(N=205) \u746a\u4ed5\u5ea6\u80bd\u00a04 mg (N=203) \u746a\u4ed5\u5ea6\u80bd\u00a06 mg (N=202) \u5b89\u6170\u5291\u00a0(N=205) \u9996\u8981\u7d42\u9ede\u00b6 \u7b2c32\u5468\u6642\u9ad4\u91cd\u8f03\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316, % \u221210.09 \u221212.55 0.45 \u221210.97 \u221213.38 \u22120.24 \u8207\u5b89\u6170\u5291\u7d44\u7684\u5dee\u7570\u00a0(97.5% CI) \u221210.54 \u00a0(\u221212.01, \u22129.08) \u221213.00 (\u221214.49,\u221211.51) \u221210.72 \u00a0(\u221212.21,\u22129.23) \u221213.14 (\u221214.64,\u221211.64) \u7b2c32\u5468\u6642\u9ad4\u91cd\u8f03\u57fa\u7dda\u964d\u5e45\u22655% \u7684\u53d7\u8a66\u8005\u6bd4\u4f8b, %\u00a7 73.9 82.0 10.5 76.3 84.0 10.9 \u9ad4\u91cd\u95dc\u9375\u6b21\u8981\u7d42\u9ede\u00b6 \u7b2c48\u5468\u6642\u9ad4\u91cd\u8f03\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316, % \u221211.00 \u221214.01 0.30 \u221212.05 \u221214.84 \u22120.47 \u8207\u5b89\u6170\u5291\u7d44\u7684\u5dee\u7570\u00a0(97.5% CI) \u221211.30 (\u221213.06, \u22129.54) \u221214.31 (\u221216.11,\u221212.51) \u221211.58 (\u221213.38, \u22129.79) \u221214.37 (\u221216.18,\u221212.56) \u7b2c48\u5468\u6642\u9ad4\u91cd\u8f03\u57fa\u7dda\u964d\u5e45\u22655% \u7684\u53d7\u8a66\u8005\u6bd4\u4f8b, %\u00a7 71.6 81.6 10.8 73.5 82.8 11.5 \u7b2c48\u5468\u6642\u9ad4\u91cd\u8f03\u57fa\u7dda\u964d\u5e45\u226510% \u7684\u53d7\u8a66\u8005\u6bd4\u4f8b, %\u00a7 53.5 66.7 2.6 55.2 67.9 2.9 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\u746a\u4ed5\u5ea6\u80bd\u986f\u8457\u964d\u4f4e\u591a\u500b\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u98a8\u96aa\u6307\u6a19 \u5728\u7b2c48\u5468\u6642\uff0c\u8170\u570d\u3001\u6536\u7e2e\u58d3\u3001\u7518\u6cb9\u4e09\u916f\u3001\u7e3d\u81bd\u56fa\u9187\u3001LDL-C\u3001\u8840\u5c3f\u9178\u548cALT\u8f03\u57fa\u7dda\u7684\u8b8a\u5316\u4e0a\uff0c\u746a\u4ed5\u5ea6\u80bd\u5747\u512a\u65bc\u5b89\u6170\u5291\uff08P<0.001\uff09\u3002 \u7642\u6548\u4f30\u8a08\u76ee\u6a19\u4e0b\uff0c\u7b2c48\u5468\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd4mg\uff0c\u746a\u4ed5\u5ea6\u80bd6mg\u548c\u5b89\u6170\u5291\u7d44\u8170\u570d\u8f03\u57fa\u7dda\u5206\u5225\u4e0b\u964d\u22129.48 cm, \u221210.96 cm \u548c \u22121.48 cm; \u746a\u4ed5\u5ea6\u80bd\u5408\u8a08\u7d44\uff084mg \u548c 6mg\uff09\u76f8\u8f03\u5b89\u6170\u5291\u7d44\u4e5f\u986f\u8457\u964d\u4f4e\u6536\u7e2e\u58d3\uff08\u22129.21 mmHg vs. \u22122.46 mmHg\uff09\u3001\u7518\u6cb9\u4e09\u916f\uff08\u22120.68 mmol\/L vs. -0.16 mmol\/L\uff09\u3001\u7e3d\u81bd\u56fa\u9187\uff08-0.32 mmol\/L vs. 0.13 mmol\/L\uff09\u3001LDL-C\uff08-0.22 mmol\/L vs. 0.09 mmol\/L\uff09\u3001\u8840\u5c3f\u9178\uff08\u221244.79 \u03bcmol\/L vs. 5.96 \u03bcmol\/L\uff09\u548cALT\uff08\u221214.50 U\/L vs.-4.50 U\/L\uff09\u3002 \u746a\u4ed5\u5ea6\u80bd\u5927\u5e45\u5ea6\u964d\u4f4e\u809d\u81df\u8102\u80aa\u542b\u91cf \u5728GLORY-1\u7684\u63a2\u7d22\u6027\u5206\u6790\u4e2d\uff0c\u5c0d\u57fa\u7dda\u809d\u81df\u8102\u80aa\u542b\u91cf\uff08MRI-PDFF\uff09\u226510%\u7684\u53d7\u8a66\u8005\uff0c\u746a\u4ed5\u5ea6\u80bd6 mg\u7d44\u53d7\u8a66\u8005\u6cbb\u764248\u5468\u5f8c\uff0c\u809d\u81df\u8102\u80aa\u542b\u91cf\u8f03\u57fa\u7dda\u5e73\u5747\u4e0b\u964d\u905480.2%\uff0c\u5b89\u6170\u5291\u7d44\u4e0b\u964d5.3%\u3002[\u8a73\u898b\u5831\u9053] \u8010\u53d7\u6027\u548c\u5b89\u5168\u6027\u826f\u597d\uff0c\u7121\u65b0\u589e\u5b89\u5168\u6027\u4fe1\u865f \u746a\u4ed5\u5ea6\u80bd\u7684\u8010\u53d7\u6027\u826f\u597d\uff0c\u746a\u4ed5\u5ea6\u80bd4 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