\u4e2d\u570b\u8607\u5dde\u548c\u7f8e\u570b\u99ac\u91cc\u862d\u5dde\u7f85\u514b\u7dad\u723e2024\u5e746\u670818\u65e5 \/\u7f8e\u901a\u793e\/ — \u81f4\u529b\u65bc\u5728\u816b\u7624\u3001\u4e59\u809d\u53ca\u8207\u8870\u8001\u76f8\u95dc\u75be\u75c5\u7b49\u6cbb\u7642\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u4f48\uff0c\u516c\u53f8\u5df2\u57282024\u5e74\u6b50\u6d32\u8840\u6db2\u5b78\u5354\u6703\u5e74\u6703\uff08EHA 2024\uff09\u4e0a\uff0c\u4ee5\u58c1\u5831\u5f62\u5f0f\u516c\u4f48\u4e86\u5728\u7814\u6838\u5fc3\u54c1\u7a2eBcl-2\u6291\u5236\u5291APG-2575\u806f\u5408\u65b0\u578b\u6cbb\u7642\u65b9\u6848\u7528\u65bc\u5fa9\u767c\/\u96e3\u6cbb\u6027\uff08R\/R\uff09\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08MM\uff09\u6216\u514d\u75ab\u7403\u86cb\u767d\u8f15\u93c8\uff08AL\uff09\u6fb1\u7c89\u6a23\u8b8a\u6027\u60a3\u8005\u7684\u6700\u65b0\u6578\u64da\u3002<\/p>\n
\n<\/div>\n
\u8a72\u9805\u7814\u7a76\u5df2\u57282023\u5e74\u7f8e\u570b\u8840\u6db2\u5b78\u6703\u5e74\u6703\u4e0a\u9996\u6b21\u62ab\u9732\u76f8\u95dc\u6578\u64da\uff0c\u6b64\u6b21\u5728EHA\u5e74\u6703\u4e0a\u7684\u6578\u64da\u66f4\u65b0\u9032\u4e00\u6b65\u9ad4\u73fe\u4e86APG-2575\u806f\u5408\u7528\u85e5\u5f37\u52c1\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u512a\u52e2\uff0c\u5728\u806f\u5408\u6cca\u99ac\u5ea6\u80fa+\u5730\u585e\u7c73\u677e\u6cbb\u7642R\/R MM\u4e2d\u5c24\u70ba\u7a81\u51fa\u30023\u7d1a\u53ca\u4ee5\u4e0a\u6cbb\u7642\u76f8\u95dc\u7684\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\u75c7\u767c\u751f\u7387\u70ba14.3%\uff0c\u6709\u671b\u70ba\u60a3\u8005\u63d0\u4f9b\u4e00\u500b\u5b89\u5168\u53ef\u9760\u7684\u6cbb\u7642\u9078\u64c7\u3002<\/p>\n
\u8a72\u9805\u81e8\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3Sikander Ailawadhi<\/span>\u6559\u6388\u8868\u793a\uff1a\u300c\u9019\u662f\u4e00\u9805APG-2575\u806f\u5408\u65b0\u578b\u6cbb\u7642\u65b9\u6848\u6cbb\u7642R\/R MM\u6216AL\u6fb1\u7c89\u6a23\u8b8a\u6027\u60a3\u8005\u7684\u7814\u7a76\u3002\u521d\u6b65\u5206\u6790\u8868\u660e\uff0cAPG-2575\u806f\u5408\u6cca\u99ac\u5ea6\u80fa\u6cbb\u7642R\/R MM\u4e2d\u2265\u975e\u5e38\u597d\u7684\u90e8\u5206\u7de9\u89e3\uff08VGPR\uff09\u7684\u503c\u9054\u523033.3%\uff0c\u4e14VGPR\u7387\u96a8APG-2575\u5291\u91cf\u7684\u589e\u52a0\u800c\u5347\u9ad8\u3002\u6b64\u5916\uff0cAPG-2575\u6cbb\u7642R\/R MM\u548c\u6fb1\u7c89\u6a23\u8b8a\u6027\u60a3\u8005\u7684\u8010\u53d7\u6027\u975e\u5e38\u597d\uff0c3\/4\u7d1a\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\u75c7\u767c\u751f\u7387\u70ba14.3%\u3002\u9019\u4e00\u4ee4\u4eba\u4fe1\u670d\u7684\u6578\u64da\u6709\u671b\u70baMM\u548c\u6fb1\u7c89\u6a23\u8b8a\u60a3\u8005\u63d0\u4f9b\u53e6\u4e00\u7a2e\u6cbb\u7642\u9078\u64c7\u3002\u300d<\/p>\n\u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300c\u6211\u5011\u5f88\u9ad8\u8208\u80fd\u5728\u672c\u6b21EHA\u5e74\u6703\u4e0a\u5206\u4eabAPG-2575\u6cbb\u7642R\/R MM\u6216AL\u6fb1\u7c89\u6a23\u8b8a\u6027\u7684\u6700\u65b0\u81e8\u5e8a\u9032\u5c55\uff0c\u9032\u4e00\u6b65\u9a57\u8b49\u8a72\u54c1\u7a2e\u806f\u5408\u7528\u85e5\u7684\u5353\u8d8a\u7684\u5b89\u5168\u6027\u548c\u7642\u6548\uff0c\u5c55\u73fe\u5176\u5168\u7403\u300eBest-in-class\u300f\u6f5b\u529b\u3002\u6211\u5011\u5c07\u7a4d\u6975\u63a8\u9032\u76f8\u95dc\u81e8\u5e8a\u958b\u767c\uff0c\u5e0c\u671b\u65e9\u65e5\u80fd\u70ba\u60a3\u8005\u5e36\u4f86\u66f4\u5b89\u5168\u6709\u6548\u7684\u6cbb\u7642\u9078\u64c7\u3002\u300d<\/p>\n
EHA\u5e74\u6703\u4f5c\u70ba\u6b50\u6d32\u8840\u6db2\u5b78\u9818\u57df\u898f\u6a21\u6700\u5927\u7684\u570b\u969b\u6703\u8b70\uff0c\u6bcf\u5e74\u5438\u5f15\u4f86\u81ea\u5168\u7403100\u591a\u500b\u570b\u5bb6\u76841\u842c\u591a\u540d\u5c08\u696d\u4eba\u58eb\u8207\u6703\uff0c\u5206\u4eab\u5168\u7403\u6700\u524d\u6cbf\u7684\u7814\u7a76\u9032\u5c55\u548c\u7a81\u7834\u6027\u81e8\u5e8a\u6578\u64da\u3002\u4e9e\u76db\u91ab\u85e5\u9084\u5728\u672c\u5c46\u5927\u6703\u4e0a\u516c\u4f48\u4e86\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5291\u5967\u96f7\u5df4\u66ff\u5c3c\uff08\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b\u00ae\uff09\u3001EED\u6291\u5236\u5291APG-5918\u7684\u6700\u65b0\u7814\u7a76\u9032\u5c55\u3002<\/p>\n
APG-2575\u5728\u6b64\u6b21EHA\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a<\/p>\n
Lisaftoclax (APG-2575) Combined with Novel Therapeutic Regimens in Patients (Pts) with Relapsed or Refractory (R\/R) Multiple Myeloma (MM) or Immunoglobulin Light-Chain (AL) Amyloidosis<\/p>\n
APG-2575\uff08Lisaftoclax\uff09\u806f\u5408\u65b0\u578b\u6cbb\u7642\u65b9\u6848\u7528\u65bc\u5fa9\u767c\/\u96e3\u6cbb\u6027\uff08R\/R\uff09\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08MM\uff09\u6216\u514d\u75ab\u7403\u86cb\u767d\u8f15\u93c8\uff08AL\uff09\u6fb1\u7c89\u6a23\u8b8a\u6027\u60a3\u8005<\/p>\n
\u6458\u8981\u7de8\u865f\uff1aP917 \u5c55\u793a\u985e\u578b\uff1a\u58c1\u5831\u5c55\u793a \u5206\u6703\u5834\u6a19\u984c\uff1a\u9aa8\u9ad3\u7624\u53ca\u5176\u5b83\u55ae\u514b\u9686\u514d\u75ab\u7403\u86cb\u767d\u75c5 \u2013 \u81e8\u5e8a\u7814\u7a76 (Myeloma and other monoclonal gammopathies \u2013 Clinical) \u65e5\u671f\u53ca\u6642\u9593\uff1a2024\u5e746\u670814\u65e5\uff0c\u661f\u671f\u4e94 18:00 \u2013 19:00 (\u6b50\u6d32\u4e2d\u90e8\u6642\u9593) \/ 2024\u5e746\u670815\u65e5\uff0c\u661f\u671f\u516d 00:00 \u2013 01:00 (\u5317\u4eac\u6642\u9593) \u5831\u544a\u4eba\uff1aSikander Ailawadhi\u6559\u6388\uff0c\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3 <\/p>\n
\u6838\u5fc3\u8981\u9ede\uff1a<\/p>\n
\u7814\u7a76\u80cc\u666f\uff1aR\/R MM\u662f\u4e00\u7a2e\u96e3\u4ee5\u6cbb\u7652\u7684\u75be\u75c5\uff0c\u5982\u679c\u4e0d\u9032\u884c\u9069\u7576\u7684\u6cbb\u7642\u5e72\u9810\uff0c\u60a3\u8005\u5e7e\u4e4e\u90fd\u6703\u5fa9\u767c\u3002AL\u6fb1\u7c89\u6a23\u8b8a\u6027\u662f\u4e00\u7a2e\u7f55\u898b\u75be\u75c5\uff0c\u6703\u5c0e\u81f4\u56b4\u91cd\u7684\u5668\u5b98\u640d\u50b7\u6216\u6b7b\u4ea1\u3002APG-2575\u662f\u4e00\u7a2e\u65b0\u578b\u5f37\u6548\u7684\u3001\u9078\u64c7\u6027Bcl-2\u6291\u5236\u5291\uff0c\u5728\u8840\u6db2\u816b\u7624\u548c\u5be6\u9ad4\u816b\u7624\u6cbb\u7642\u4e2d\u5747\u5177\u6709\u81e8\u5e8a\u6f5b\u529b\uff0c\u4e26\u4e14\u5831\u544a\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08AEs\uff09\u767c\u751f\u7387\u8f03\u4f4e\u3002
\n\u7814\u7a76\u4ecb\u7d39\uff1a\u8a72\u9805\u591a\u4e2d\u5fc3\u81e8\u5e8a\u7814\u7a76\u65e8\u5728\u8a55\u4f30APG-2575\u806f\u5408\u6cca\u99ac\u5ea6\u80fa\u3001\u5730\u585e\u7c73\u677e\uff08A\u548cC\u7d44\uff09\u6216\u9054\u96f7\u59a5\u5c24\u55ae\u6297\u3001\u4f86\u90a3\u5ea6\u80fa\u3001\u5730\u585e\u7c73\u677e\uff08B\u7d44\uff09\u5206\u5225\u5728R\/R MM\uff08A\u548cB\u7d44\uff09\u6216R\/R AL\u6fb1\u7c89\u6a23\u8b8a\u6027\uff08C\u7d44\uff09\u60a3\u8005\u4e2d\u7684\u7642\u6548\u6027\u548c\u5b89\u5168\u6027\u3002
\n\u5165\u7d44\u60a3\u8005\u548c\u7814\u7a76\u65b9\u6cd5\uff1aECOG\u9ad4\u529b\u72c0\u6cc1\u8a55\u5206\u2264 2\u7684\u60a3\u8005\u63a5\u53d7\u4e86APG-2575\u6bcf\u65e5\u7d66\u85e5\uff0c28\u5929\/\u9031\u671f\u3002\u6cca\u99ac\u5ea6\u80fa\u3001\u9054\u96f7\u59a5\u5c24\u55ae\u6297\u3001\u4f86\u90a3\u5ea6\u80fa\u5747\u6309\u7167\u8aaa\u660e\u66f8\u4f7f\u7528\u65b9\u6cd5\u7d66\u85e5\u3002\u5730\u585e\u7c73\u677e\u7684\u7d66\u85e5\u5291\u91cf\u70ba40mg\/\u5929\uff0c\u5e74\u9f61>75\u6b72\u7684\u60a3\u8005\u6e1b\u91cf\u70ba20mg\/\u5929\u3002
\n\u622a\u81f32024\u5e741\u670825\u65e5\uff0c44\u4f8b\u60a3\u8005\u88ab\u7d0d\u5165\u7814\u7a76\uff0c\u5176\u4e2d36\u4f8bR\/R MM\u548c8\u4f8bR\/R AL\u6fb1\u7c89\u6a23\u8b8a\u6027\uff0c\u5206\u4f48\u5728\u4e09\u500b\u7d44\uff08A\u7d44\u3001B\u7d44\u548cC\u7d44\uff09\uff0c\u63a5\u53d7\u4e0d\u540c\u5291\u91cf\u7684APG-2575\u6cbb\u7642\uff1b \u60a3\u8005\u7684\u4e2d\u4f4d\u5e74\u9f61\u70ba70.5\u6b72\uff0824-88\u6b72\uff09\uff0c68.2%\u70ba\u7537\u6027\uff0c65.9%\u5e74\u9f61\u8d85\u904e65\u6b72\uff1b \u5148\u524d\u6cbb\u7642\u7dda\u6578\u7684\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u70ba3\uff081-19\uff09\uff0c\u5f9e\u8a3a\u65b7\u5230\u7814\u7a76\u85e5\u7269\u9996\u6b21\u5291\u91cf\u7684\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u6642\u9593\u70ba5.5\u5e74\uff081-29\u5e74\uff09\uff0c\u6cbb\u7642\u9031\u671f\u7684\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u70ba4\uff081-26\uff09\u3002 <\/p>\n
\u7642\u6548\u6578\u64da\uff1a
\nA\u7d44\u4e2d\uff0c27\u4f8bR\/R MM\u60a3\u8005\u53ef\u8a55\u4f30\u7642\u6548\uff0c\u5176\u4e2d10\u4f8b\u6709\u90e8\u5206\u7de9\u89e3\uff08PR\uff09\uff0c7\u4f8b\u975e\u5e38\u597d\u7684\u90e8\u5206\u7de9\u89e3\uff08VGPR\uff09\uff0c2\u4f8b\u5b8c\u5168\u7de9\u89e3\uff08CR\uff09\u3002\u7e3d\u7de9\u89e3\u7387\uff08ORR [PR+VGPR+CR]\uff09\u70ba70.4%\uff1b\u00a0 B\u7d44\u4e2d\uff0c2\u4f8bR\/R MM\u60a3\u8005\u9054\u5230CR\uff1b\u00a0 C\u7d44\u4e2d\uff0c\u67097\u4f8bR\/R AL\u6fb1\u7c89\u6a23\u8b8a\u6027\u60a3\u8005\u53ef\u4ee5\u8a55\u4f30\u7642\u6548\uff0cORR\u70ba85.7%\uff084\u4f8bVGPR\uff0c2\u4f8bCR\uff09\u3002 <\/p>\n
\u5b89\u5168\u6027\u6578\u64da\uff1a\u00a0
\n\u572842\u4f8b\u5b89\u5168\u6027\u5206\u6790\u4eba\u7fa4\u4e2d\uff0c10\u4f8b\u60a3\u8005\u5831\u544a\u4e86\u22653\u7d1a\u7684\u8207\u6cbb\u7642\u76f8\u95dc\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TRAEs\uff09\uff0c\u5305\u62ec\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\uff0814.3%\uff09\u548c\u767c\u71b1\u6027\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\uff082.4%\uff09\u7b49\u30023\u4f8b\u60a3\u8005\u767c\u751f\u56b4\u91cdTRAEs\uff0c\u767c\u71b1\u6027\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\u3001\u6025\u6027\u814e\u640d\u50b7\u548c\u8179\u7009\u53ca\u96fb\u89e3\u8cea\u5931\u8861\u54041\u4f8b\uff1b\u00a0 \u5171\u670924\u4f8b\u60a3\u8005\u56e0\u75be\u75c5\u9032\u5c55\uff08n=15\uff09\u3001\u6cbb\u7642\u671f\u9593\u51fa\u73fe\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TEAE\uff09\uff08n=3\uff09\u3001\u4f9d\u5f9e\u6027\u4e0d\u4f73\uff08n=1\uff09\u6216\u7814\u7a76\u8005\/\u60a3\u8005\u6c7a\u5b9a\uff08n=5\uff09\u800c\u4e2d\u65b7\u6cbb\u7642\u3002 <\/p>\n
\u7d50\u8ad6\uff1aAPG-2575\u806f\u5408\u6cbb\u7642\u65b9\u6848\u5728R\/R MM\u548cAL\u6fb1\u7c89\u6a23\u8b8a\u6027\u60a3\u8005\u4e2d\u8868\u73fe\u51fa\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u4e26\u986f\u793a\u51fa\u660e\u986f\u6297\u816b\u7624\u6d3b\u6027\u3002 <\/p>\n
\u95dc\u65bc\u4e9e\u76db\u91ab\u85e5<\/p>\n
\u4e9e\u76db\u91ab\u85e5\u662f\u4e00\u5bb6\u7acb\u8db3\u4e2d\u570b\u3001\u9762\u5411\u5168\u7403\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u5728\u816b\u7624\u3001\u4e59\u809d\u53ca\u8207\u8870\u8001\u76f8\u95dc\u7684\u75be\u75c5\u7b49\u6cbb\u7642\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u30022019\u5e7410\u670828\u65e5\uff0c\u4e9e\u76db\u91ab\u85e5\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e3b\u677f\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6855.HK\u3002<\/p>\n
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EHA\u5e74\u6703\u4f5c\u70ba\u6b50\u6d32\u8840\u6db2\u5b78\u9818\u57df\u898f\u6a21\u6700\u5927\u7684\u570b\u969b\u6703\u8b70\uff0c\u6bcf\u5e74\u5438\u5f15\u4f86\u81ea\u5168\u7403100\u591a\u500b\u570b\u5bb6\u76841\u842c\u591a\u540d\u5c08\u696d\u4eba\u58eb\u8207\u6703\uff0c\u5206\u4eab\u5168\u7403\u6700\u524d\u6cbf\u7684\u7814\u7a76\u9032\u5c55\u548c\u7a81\u7834\u6027\u81e8\u5e8a\u6578\u64da\u3002\u4e9e\u76db\u91ab\u85e5\u9084\u5728\u672c\u5c46\u5927\u6703\u4e0a\u516c\u4f48\u4e86\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5291\u5967\u96f7\u5df4\u66ff\u5c3c\uff08\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b\u00ae\uff09\u3001EED\u6291\u5236\u5291APG-5918\u7684\u6700\u65b0\u7814\u7a76\u9032\u5c55\u3002 APG-2575\u5728\u6b64\u6b21EHA\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a Lisaftoclax (APG-2575) Combined with Novel Therapeutic Regimens in Patients (Pts) with Relapsed or Refractory (R\/R) Multiple Myeloma (MM) or Immunoglobulin Light-Chain (AL) Amyloidosis APG-2575\uff08Lisaftoclax\uff09\u806f\u5408\u65b0\u578b\u6cbb\u7642\u65b9\u6848\u7528\u65bc\u5fa9\u767c\/\u96e3\u6cbb\u6027\uff08R\/R\uff09\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08MM\uff09\u6216\u514d\u75ab\u7403\u86cb\u767d\u8f15\u93c8\uff08AL\uff09\u6fb1\u7c89\u6a23\u8b8a\u6027\u60a3\u8005 \u6458\u8981\u7de8\u865f\uff1aP917 \u5c55\u793a\u985e\u578b\uff1a\u58c1\u5831\u5c55\u793a \u5206\u6703\u5834\u6a19\u984c\uff1a\u9aa8\u9ad3\u7624\u53ca\u5176\u5b83\u55ae\u514b\u9686\u514d\u75ab\u7403\u86cb\u767d\u75c5 \u2013 \u81e8\u5e8a\u7814\u7a76 (Myeloma and other monoclonal gammopathies \u2013 Clinical) \u65e5\u671f\u53ca\u6642\u9593\uff1a2024\u5e746\u670814\u65e5\uff0c\u661f\u671f\u4e94 18:00 \u2013 19:00 (\u6b50\u6d32\u4e2d\u90e8\u6642\u9593) \/ 2024\u5e746\u670815\u65e5\uff0c\u661f\u671f\u516d 00:00 \u2013 01:00 (\u5317\u4eac\u6642\u9593) \u5831\u544a\u4eba\uff1aSikander Ailawadhi\u6559\u6388\uff0c\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3 \u6838\u5fc3\u8981\u9ede\uff1a \u7814\u7a76\u80cc\u666f\uff1aR\/R MM\u662f\u4e00\u7a2e\u96e3\u4ee5\u6cbb\u7652\u7684\u75be\u75c5\uff0c\u5982\u679c\u4e0d\u9032\u884c\u9069\u7576\u7684\u6cbb\u7642\u5e72\u9810\uff0c\u60a3\u8005\u5e7e\u4e4e\u90fd\u6703\u5fa9\u767c\u3002AL\u6fb1\u7c89\u6a23\u8b8a\u6027\u662f\u4e00\u7a2e\u7f55\u898b\u75be\u75c5\uff0c\u6703\u5c0e\u81f4\u56b4\u91cd\u7684\u5668\u5b98\u640d\u50b7\u6216\u6b7b\u4ea1\u3002APG-2575\u662f\u4e00\u7a2e\u65b0\u578b\u5f37\u6548\u7684\u3001\u9078\u64c7\u6027Bcl-2\u6291\u5236\u5291\uff0c\u5728\u8840\u6db2\u816b\u7624\u548c\u5be6\u9ad4\u816b\u7624\u6cbb\u7642\u4e2d\u5747\u5177\u6709\u81e8\u5e8a\u6f5b\u529b\uff0c\u4e26\u4e14\u5831\u544a\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08AEs\uff09\u767c\u751f\u7387\u8f03\u4f4e\u3002 \u7814\u7a76\u4ecb\u7d39\uff1a\u8a72\u9805\u591a\u4e2d\u5fc3\u81e8\u5e8a\u7814\u7a76\u65e8\u5728\u8a55\u4f30APG-2575\u806f\u5408\u6cca\u99ac\u5ea6\u80fa\u3001\u5730\u585e\u7c73\u677e\uff08A\u548cC\u7d44\uff09\u6216\u9054\u96f7\u59a5\u5c24\u55ae\u6297\u3001\u4f86\u90a3\u5ea6\u80fa\u3001\u5730\u585e\u7c73\u677e\uff08B\u7d44\uff09\u5206\u5225\u5728R\/R MM\uff08A\u548cB\u7d44\uff09\u6216R\/R AL\u6fb1\u7c89\u6a23\u8b8a\u6027\uff08C\u7d44\uff09\u60a3\u8005\u4e2d\u7684\u7642\u6548\u6027\u548c\u5b89\u5168\u6027\u3002 \u5165\u7d44\u60a3\u8005\u548c\u7814\u7a76\u65b9\u6cd5\uff1aECOG\u9ad4\u529b\u72c0\u6cc1\u8a55\u5206\u2264 2\u7684\u60a3\u8005\u63a5\u53d7\u4e86APG-2575\u6bcf\u65e5\u7d66\u85e5\uff0c28\u5929\/\u9031\u671f\u3002\u6cca\u99ac\u5ea6\u80fa\u3001\u9054\u96f7\u59a5\u5c24\u55ae\u6297\u3001\u4f86\u90a3\u5ea6\u80fa\u5747\u6309\u7167\u8aaa\u660e\u66f8\u4f7f\u7528\u65b9\u6cd5\u7d66\u85e5\u3002\u5730\u585e\u7c73\u677e\u7684\u7d66\u85e5\u5291\u91cf\u70ba40mg\/\u5929\uff0c\u5e74\u9f61>75\u6b72\u7684\u60a3\u8005\u6e1b\u91cf\u70ba20mg\/\u5929\u3002 \u622a\u81f32024\u5e741\u670825\u65e5\uff0c44\u4f8b\u60a3\u8005\u88ab\u7d0d\u5165\u7814\u7a76\uff0c\u5176\u4e2d36\u4f8bR\/R MM\u548c8\u4f8bR\/R AL\u6fb1\u7c89\u6a23\u8b8a\u6027\uff0c\u5206\u4f48\u5728\u4e09\u500b\u7d44\uff08A\u7d44\u3001B\u7d44\u548cC\u7d44\uff09\uff0c\u63a5\u53d7\u4e0d\u540c\u5291\u91cf\u7684APG-2575\u6cbb\u7642\uff1b \u60a3\u8005\u7684\u4e2d\u4f4d\u5e74\u9f61\u70ba70.5\u6b72\uff0824-88\u6b72\uff09\uff0c68.2%\u70ba\u7537\u6027\uff0c65.9%\u5e74\u9f61\u8d85\u904e65\u6b72\uff1b 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AL\u6fb1\u7c89\u6a23\u8b8a\u6027\u60a3\u8005\u53ef\u4ee5\u8a55\u4f30\u7642\u6548\uff0cORR\u70ba85.7%\uff084\u4f8bVGPR\uff0c2\u4f8bCR\uff09\u3002 \u5b89\u5168\u6027\u6578\u64da\uff1a\u00a0 \u572842\u4f8b\u5b89\u5168\u6027\u5206\u6790\u4eba\u7fa4\u4e2d\uff0c10\u4f8b\u60a3\u8005\u5831\u544a\u4e86\u22653\u7d1a\u7684\u8207\u6cbb\u7642\u76f8\u95dc\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TRAEs\uff09\uff0c\u5305\u62ec\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\uff0814.3%\uff09\u548c\u767c\u71b1\u6027\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\uff082.4%\uff09\u7b49\u30023\u4f8b\u60a3\u8005\u767c\u751f\u56b4\u91cdTRAEs\uff0c\u767c\u71b1\u6027\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\u3001\u6025\u6027\u814e\u640d\u50b7\u548c\u8179\u7009\u53ca\u96fb\u89e3\u8cea\u5931\u8861\u54041\u4f8b\uff1b\u00a0 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\u3010\u76f4\u64caEHA 2024\u3011\u4e9e\u76db\u91ab\u85e5Bcl-2\u6291\u5236\u5291APG-2575\u6cbb\u7642R\/R MM\u548cAL\u6fb1\u7c89\u6a23\u8b8a\u6027\u6578\u64da\u66f4\u65b0\uff0c\u7e3d\u7de9\u89e3\u7387\u986f\u8457\u63d0\u9ad8 - \u9999\u6e2f\u7279\u8a31\u7d93\u71df<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.franchise.com.hk\/en\/%e3%80%90%e7%9b%b4%e6%93%8aeha-2024%e3%80%91%e4%ba%9e%e7%9b%9b%e9%86%ab%e8%97%a5bcl-2%e6%8a%91%e5%88%b6%e5%8a%91apg-2575%e6%b2%bb%e7%99%82r-r-mm%e5%92%8cal%e6%be%b1%e7%b2%89%e6%a8%a3%e8%ae%8a%e6%80%a7\/19865\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u3010\u76f4\u64caEHA 2024\u3011\u4e9e\u76db\u91ab\u85e5Bcl-2\u6291\u5236\u5291APG-2575\u6cbb\u7642R\/R MM\u548cAL\u6fb1\u7c89\u6a23\u8b8a\u6027\u6578\u64da\u66f4\u65b0\uff0c\u7e3d\u7de9\u89e3\u7387\u986f\u8457\u63d0\u9ad8 - \u9999\u6e2f\u7279\u8a31\u7d93\u71df\" \/>\n<meta property=\"og:description\" content=\"\u4e2d\u570b\u8607\u5dde\u548c\u7f8e\u570b\u99ac\u91cc\u862d\u5dde\u7f85\u514b\u7dad\u723e2024\u5e746\u670818\u65e5 \/\u7f8e\u901a\u793e\/ — \u81f4\u529b\u65bc\u5728\u816b\u7624\u3001\u4e59\u809d\u53ca\u8207\u8870\u8001\u76f8\u95dc\u75be\u75c5\u7b49\u6cbb\u7642\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u4f48\uff0c\u516c\u53f8\u5df2\u57282024\u5e74\u6b50\u6d32\u8840\u6db2\u5b78\u5354\u6703\u5e74\u6703\uff08EHA 2024\uff09\u4e0a\uff0c\u4ee5\u58c1\u5831\u5f62\u5f0f\u516c\u4f48\u4e86\u5728\u7814\u6838\u5fc3\u54c1\u7a2eBcl-2\u6291\u5236\u5291APG-2575\u806f\u5408\u65b0\u578b\u6cbb\u7642\u65b9\u6848\u7528\u65bc\u5fa9\u767c\/\u96e3\u6cbb\u6027\uff08R\/R\uff09\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08MM\uff09\u6216\u514d\u75ab\u7403\u86cb\u767d\u8f15\u93c8\uff08AL\uff09\u6fb1\u7c89\u6a23\u8b8a\u6027\u60a3\u8005\u7684\u6700\u65b0\u6578\u64da\u3002 \u8a72\u9805\u7814\u7a76\u5df2\u57282023\u5e74\u7f8e\u570b\u8840\u6db2\u5b78\u6703\u5e74\u6703\u4e0a\u9996\u6b21\u62ab\u9732\u76f8\u95dc\u6578\u64da\uff0c\u6b64\u6b21\u5728EHA\u5e74\u6703\u4e0a\u7684\u6578\u64da\u66f4\u65b0\u9032\u4e00\u6b65\u9ad4\u73fe\u4e86APG-2575\u806f\u5408\u7528\u85e5\u5f37\u52c1\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u512a\u52e2\uff0c\u5728\u806f\u5408\u6cca\u99ac\u5ea6\u80fa+\u5730\u585e\u7c73\u677e\u6cbb\u7642R\/R MM\u4e2d\u5c24\u70ba\u7a81\u51fa\u30023\u7d1a\u53ca\u4ee5\u4e0a\u6cbb\u7642\u76f8\u95dc\u7684\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\u75c7\u767c\u751f\u7387\u70ba14.3%\uff0c\u6709\u671b\u70ba\u60a3\u8005\u63d0\u4f9b\u4e00\u500b\u5b89\u5168\u53ef\u9760\u7684\u6cbb\u7642\u9078\u64c7\u3002 \u8a72\u9805\u81e8\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3Sikander Ailawadhi\u6559\u6388\u8868\u793a\uff1a\u300c\u9019\u662f\u4e00\u9805APG-2575\u806f\u5408\u65b0\u578b\u6cbb\u7642\u65b9\u6848\u6cbb\u7642R\/R MM\u6216AL\u6fb1\u7c89\u6a23\u8b8a\u6027\u60a3\u8005\u7684\u7814\u7a76\u3002\u521d\u6b65\u5206\u6790\u8868\u660e\uff0cAPG-2575\u806f\u5408\u6cca\u99ac\u5ea6\u80fa\u6cbb\u7642R\/R MM\u4e2d\u2265\u975e\u5e38\u597d\u7684\u90e8\u5206\u7de9\u89e3\uff08VGPR\uff09\u7684\u503c\u9054\u523033.3%\uff0c\u4e14VGPR\u7387\u96a8APG-2575\u5291\u91cf\u7684\u589e\u52a0\u800c\u5347\u9ad8\u3002\u6b64\u5916\uff0cAPG-2575\u6cbb\u7642R\/R MM\u548c\u6fb1\u7c89\u6a23\u8b8a\u6027\u60a3\u8005\u7684\u8010\u53d7\u6027\u975e\u5e38\u597d\uff0c3\/4\u7d1a\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\u75c7\u767c\u751f\u7387\u70ba14.3%\u3002\u9019\u4e00\u4ee4\u4eba\u4fe1\u670d\u7684\u6578\u64da\u6709\u671b\u70baMM\u548c\u6fb1\u7c89\u6a23\u8b8a\u60a3\u8005\u63d0\u4f9b\u53e6\u4e00\u7a2e\u6cbb\u7642\u9078\u64c7\u3002\u300d \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300c\u6211\u5011\u5f88\u9ad8\u8208\u80fd\u5728\u672c\u6b21EHA\u5e74\u6703\u4e0a\u5206\u4eabAPG-2575\u6cbb\u7642R\/R MM\u6216AL\u6fb1\u7c89\u6a23\u8b8a\u6027\u7684\u6700\u65b0\u81e8\u5e8a\u9032\u5c55\uff0c\u9032\u4e00\u6b65\u9a57\u8b49\u8a72\u54c1\u7a2e\u806f\u5408\u7528\u85e5\u7684\u5353\u8d8a\u7684\u5b89\u5168\u6027\u548c\u7642\u6548\uff0c\u5c55\u73fe\u5176\u5168\u7403\u300eBest-in-class\u300f\u6f5b\u529b\u3002\u6211\u5011\u5c07\u7a4d\u6975\u63a8\u9032\u76f8\u95dc\u81e8\u5e8a\u958b\u767c\uff0c\u5e0c\u671b\u65e9\u65e5\u80fd\u70ba\u60a3\u8005\u5e36\u4f86\u66f4\u5b89\u5168\u6709\u6548\u7684\u6cbb\u7642\u9078\u64c7\u3002\u300d EHA\u5e74\u6703\u4f5c\u70ba\u6b50\u6d32\u8840\u6db2\u5b78\u9818\u57df\u898f\u6a21\u6700\u5927\u7684\u570b\u969b\u6703\u8b70\uff0c\u6bcf\u5e74\u5438\u5f15\u4f86\u81ea\u5168\u7403100\u591a\u500b\u570b\u5bb6\u76841\u842c\u591a\u540d\u5c08\u696d\u4eba\u58eb\u8207\u6703\uff0c\u5206\u4eab\u5168\u7403\u6700\u524d\u6cbf\u7684\u7814\u7a76\u9032\u5c55\u548c\u7a81\u7834\u6027\u81e8\u5e8a\u6578\u64da\u3002\u4e9e\u76db\u91ab\u85e5\u9084\u5728\u672c\u5c46\u5927\u6703\u4e0a\u516c\u4f48\u4e86\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5291\u5967\u96f7\u5df4\u66ff\u5c3c\uff08\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b\u00ae\uff09\u3001EED\u6291\u5236\u5291APG-5918\u7684\u6700\u65b0\u7814\u7a76\u9032\u5c55\u3002 APG-2575\u5728\u6b64\u6b21EHA\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a Lisaftoclax (APG-2575) Combined with Novel Therapeutic Regimens in Patients (Pts) with Relapsed or Refractory (R\/R) Multiple Myeloma (MM) or Immunoglobulin Light-Chain (AL) Amyloidosis APG-2575\uff08Lisaftoclax\uff09\u806f\u5408\u65b0\u578b\u6cbb\u7642\u65b9\u6848\u7528\u65bc\u5fa9\u767c\/\u96e3\u6cbb\u6027\uff08R\/R\uff09\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08MM\uff09\u6216\u514d\u75ab\u7403\u86cb\u767d\u8f15\u93c8\uff08AL\uff09\u6fb1\u7c89\u6a23\u8b8a\u6027\u60a3\u8005 \u6458\u8981\u7de8\u865f\uff1aP917 \u5c55\u793a\u985e\u578b\uff1a\u58c1\u5831\u5c55\u793a \u5206\u6703\u5834\u6a19\u984c\uff1a\u9aa8\u9ad3\u7624\u53ca\u5176\u5b83\u55ae\u514b\u9686\u514d\u75ab\u7403\u86cb\u767d\u75c5 \u2013 \u81e8\u5e8a\u7814\u7a76 (Myeloma and other monoclonal gammopathies \u2013 Clinical) \u65e5\u671f\u53ca\u6642\u9593\uff1a2024\u5e746\u670814\u65e5\uff0c\u661f\u671f\u4e94 18:00 \u2013 19:00 (\u6b50\u6d32\u4e2d\u90e8\u6642\u9593) \/ 2024\u5e746\u670815\u65e5\uff0c\u661f\u671f\u516d 00:00 \u2013 01:00 (\u5317\u4eac\u6642\u9593) \u5831\u544a\u4eba\uff1aSikander Ailawadhi\u6559\u6388\uff0c\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3 \u6838\u5fc3\u8981\u9ede\uff1a \u7814\u7a76\u80cc\u666f\uff1aR\/R MM\u662f\u4e00\u7a2e\u96e3\u4ee5\u6cbb\u7652\u7684\u75be\u75c5\uff0c\u5982\u679c\u4e0d\u9032\u884c\u9069\u7576\u7684\u6cbb\u7642\u5e72\u9810\uff0c\u60a3\u8005\u5e7e\u4e4e\u90fd\u6703\u5fa9\u767c\u3002AL\u6fb1\u7c89\u6a23\u8b8a\u6027\u662f\u4e00\u7a2e\u7f55\u898b\u75be\u75c5\uff0c\u6703\u5c0e\u81f4\u56b4\u91cd\u7684\u5668\u5b98\u640d\u50b7\u6216\u6b7b\u4ea1\u3002APG-2575\u662f\u4e00\u7a2e\u65b0\u578b\u5f37\u6548\u7684\u3001\u9078\u64c7\u6027Bcl-2\u6291\u5236\u5291\uff0c\u5728\u8840\u6db2\u816b\u7624\u548c\u5be6\u9ad4\u816b\u7624\u6cbb\u7642\u4e2d\u5747\u5177\u6709\u81e8\u5e8a\u6f5b\u529b\uff0c\u4e26\u4e14\u5831\u544a\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08AEs\uff09\u767c\u751f\u7387\u8f03\u4f4e\u3002 \u7814\u7a76\u4ecb\u7d39\uff1a\u8a72\u9805\u591a\u4e2d\u5fc3\u81e8\u5e8a\u7814\u7a76\u65e8\u5728\u8a55\u4f30APG-2575\u806f\u5408\u6cca\u99ac\u5ea6\u80fa\u3001\u5730\u585e\u7c73\u677e\uff08A\u548cC\u7d44\uff09\u6216\u9054\u96f7\u59a5\u5c24\u55ae\u6297\u3001\u4f86\u90a3\u5ea6\u80fa\u3001\u5730\u585e\u7c73\u677e\uff08B\u7d44\uff09\u5206\u5225\u5728R\/R MM\uff08A\u548cB\u7d44\uff09\u6216R\/R AL\u6fb1\u7c89\u6a23\u8b8a\u6027\uff08C\u7d44\uff09\u60a3\u8005\u4e2d\u7684\u7642\u6548\u6027\u548c\u5b89\u5168\u6027\u3002 \u5165\u7d44\u60a3\u8005\u548c\u7814\u7a76\u65b9\u6cd5\uff1aECOG\u9ad4\u529b\u72c0\u6cc1\u8a55\u5206\u2264 2\u7684\u60a3\u8005\u63a5\u53d7\u4e86APG-2575\u6bcf\u65e5\u7d66\u85e5\uff0c28\u5929\/\u9031\u671f\u3002\u6cca\u99ac\u5ea6\u80fa\u3001\u9054\u96f7\u59a5\u5c24\u55ae\u6297\u3001\u4f86\u90a3\u5ea6\u80fa\u5747\u6309\u7167\u8aaa\u660e\u66f8\u4f7f\u7528\u65b9\u6cd5\u7d66\u85e5\u3002\u5730\u585e\u7c73\u677e\u7684\u7d66\u85e5\u5291\u91cf\u70ba40mg\/\u5929\uff0c\u5e74\u9f61>75\u6b72\u7684\u60a3\u8005\u6e1b\u91cf\u70ba20mg\/\u5929\u3002 \u622a\u81f32024\u5e741\u670825\u65e5\uff0c44\u4f8b\u60a3\u8005\u88ab\u7d0d\u5165\u7814\u7a76\uff0c\u5176\u4e2d36\u4f8bR\/R MM\u548c8\u4f8bR\/R AL\u6fb1\u7c89\u6a23\u8b8a\u6027\uff0c\u5206\u4f48\u5728\u4e09\u500b\u7d44\uff08A\u7d44\u3001B\u7d44\u548cC\u7d44\uff09\uff0c\u63a5\u53d7\u4e0d\u540c\u5291\u91cf\u7684APG-2575\u6cbb\u7642\uff1b \u60a3\u8005\u7684\u4e2d\u4f4d\u5e74\u9f61\u70ba70.5\u6b72\uff0824-88\u6b72\uff09\uff0c68.2%\u70ba\u7537\u6027\uff0c65.9%\u5e74\u9f61\u8d85\u904e65\u6b72\uff1b \u5148\u524d\u6cbb\u7642\u7dda\u6578\u7684\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u70ba3\uff081-19\uff09\uff0c\u5f9e\u8a3a\u65b7\u5230\u7814\u7a76\u85e5\u7269\u9996\u6b21\u5291\u91cf\u7684\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u6642\u9593\u70ba5.5\u5e74\uff081-29\u5e74\uff09\uff0c\u6cbb\u7642\u9031\u671f\u7684\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u70ba4\uff081-26\uff09\u3002 \u7642\u6548\u6578\u64da\uff1a A\u7d44\u4e2d\uff0c27\u4f8bR\/R MM\u60a3\u8005\u53ef\u8a55\u4f30\u7642\u6548\uff0c\u5176\u4e2d10\u4f8b\u6709\u90e8\u5206\u7de9\u89e3\uff08PR\uff09\uff0c7\u4f8b\u975e\u5e38\u597d\u7684\u90e8\u5206\u7de9\u89e3\uff08VGPR\uff09\uff0c2\u4f8b\u5b8c\u5168\u7de9\u89e3\uff08CR\uff09\u3002\u7e3d\u7de9\u89e3\u7387\uff08ORR [PR+VGPR+CR]\uff09\u70ba70.4%\uff1b\u00a0 B\u7d44\u4e2d\uff0c2\u4f8bR\/R MM\u60a3\u8005\u9054\u5230CR\uff1b\u00a0 C\u7d44\u4e2d\uff0c\u67097\u4f8bR\/R AL\u6fb1\u7c89\u6a23\u8b8a\u6027\u60a3\u8005\u53ef\u4ee5\u8a55\u4f30\u7642\u6548\uff0cORR\u70ba85.7%\uff084\u4f8bVGPR\uff0c2\u4f8bCR\uff09\u3002 \u5b89\u5168\u6027\u6578\u64da\uff1a\u00a0 \u572842\u4f8b\u5b89\u5168\u6027\u5206\u6790\u4eba\u7fa4\u4e2d\uff0c10\u4f8b\u60a3\u8005\u5831\u544a\u4e86\u22653\u7d1a\u7684\u8207\u6cbb\u7642\u76f8\u95dc\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TRAEs\uff09\uff0c\u5305\u62ec\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\uff0814.3%\uff09\u548c\u767c\u71b1\u6027\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\uff082.4%\uff09\u7b49\u30023\u4f8b\u60a3\u8005\u767c\u751f\u56b4\u91cdTRAEs\uff0c\u767c\u71b1\u6027\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\u3001\u6025\u6027\u814e\u640d\u50b7\u548c\u8179\u7009\u53ca\u96fb\u89e3\u8cea\u5931\u8861\u54041\u4f8b\uff1b\u00a0 \u5171\u670924\u4f8b\u60a3\u8005\u56e0\u75be\u75c5\u9032\u5c55\uff08n=15\uff09\u3001\u6cbb\u7642\u671f\u9593\u51fa\u73fe\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TEAE\uff09\uff08n=3\uff09\u3001\u4f9d\u5f9e\u6027\u4e0d\u4f73\uff08n=1\uff09\u6216\u7814\u7a76\u8005\/\u60a3\u8005\u6c7a\u5b9a\uff08n=5\uff09\u800c\u4e2d\u65b7\u6cbb\u7642\u3002 \u7d50\u8ad6\uff1aAPG-2575\u806f\u5408\u6cbb\u7642\u65b9\u6848\u5728R\/R MM\u548cAL\u6fb1\u7c89\u6a23\u8b8a\u6027\u60a3\u8005\u4e2d\u8868\u73fe\u51fa\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u4e26\u986f\u793a\u51fa\u660e\u986f\u6297\u816b\u7624\u6d3b\u6027\u3002 \u95dc\u65bc\u4e9e\u76db\u91ab\u85e5 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MM\u4e2d\u5c24\u70ba\u7a81\u51fa\u30023\u7d1a\u53ca\u4ee5\u4e0a\u6cbb\u7642\u76f8\u95dc\u7684\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\u75c7\u767c\u751f\u7387\u70ba14.3%\uff0c\u6709\u671b\u70ba\u60a3\u8005\u63d0\u4f9b\u4e00\u500b\u5b89\u5168\u53ef\u9760\u7684\u6cbb\u7642\u9078\u64c7\u3002 \u8a72\u9805\u81e8\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3Sikander Ailawadhi\u6559\u6388\u8868\u793a\uff1a\u300c\u9019\u662f\u4e00\u9805APG-2575\u806f\u5408\u65b0\u578b\u6cbb\u7642\u65b9\u6848\u6cbb\u7642R\/R MM\u6216AL\u6fb1\u7c89\u6a23\u8b8a\u6027\u60a3\u8005\u7684\u7814\u7a76\u3002\u521d\u6b65\u5206\u6790\u8868\u660e\uff0cAPG-2575\u806f\u5408\u6cca\u99ac\u5ea6\u80fa\u6cbb\u7642R\/R MM\u4e2d\u2265\u975e\u5e38\u597d\u7684\u90e8\u5206\u7de9\u89e3\uff08VGPR\uff09\u7684\u503c\u9054\u523033.3%\uff0c\u4e14VGPR\u7387\u96a8APG-2575\u5291\u91cf\u7684\u589e\u52a0\u800c\u5347\u9ad8\u3002\u6b64\u5916\uff0cAPG-2575\u6cbb\u7642R\/R MM\u548c\u6fb1\u7c89\u6a23\u8b8a\u6027\u60a3\u8005\u7684\u8010\u53d7\u6027\u975e\u5e38\u597d\uff0c3\/4\u7d1a\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\u75c7\u767c\u751f\u7387\u70ba14.3%\u3002\u9019\u4e00\u4ee4\u4eba\u4fe1\u670d\u7684\u6578\u64da\u6709\u671b\u70baMM\u548c\u6fb1\u7c89\u6a23\u8b8a\u60a3\u8005\u63d0\u4f9b\u53e6\u4e00\u7a2e\u6cbb\u7642\u9078\u64c7\u3002\u300d \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300c\u6211\u5011\u5f88\u9ad8\u8208\u80fd\u5728\u672c\u6b21EHA\u5e74\u6703\u4e0a\u5206\u4eabAPG-2575\u6cbb\u7642R\/R MM\u6216AL\u6fb1\u7c89\u6a23\u8b8a\u6027\u7684\u6700\u65b0\u81e8\u5e8a\u9032\u5c55\uff0c\u9032\u4e00\u6b65\u9a57\u8b49\u8a72\u54c1\u7a2e\u806f\u5408\u7528\u85e5\u7684\u5353\u8d8a\u7684\u5b89\u5168\u6027\u548c\u7642\u6548\uff0c\u5c55\u73fe\u5176\u5168\u7403\u300eBest-in-class\u300f\u6f5b\u529b\u3002\u6211\u5011\u5c07\u7a4d\u6975\u63a8\u9032\u76f8\u95dc\u81e8\u5e8a\u958b\u767c\uff0c\u5e0c\u671b\u65e9\u65e5\u80fd\u70ba\u60a3\u8005\u5e36\u4f86\u66f4\u5b89\u5168\u6709\u6548\u7684\u6cbb\u7642\u9078\u64c7\u3002\u300d EHA\u5e74\u6703\u4f5c\u70ba\u6b50\u6d32\u8840\u6db2\u5b78\u9818\u57df\u898f\u6a21\u6700\u5927\u7684\u570b\u969b\u6703\u8b70\uff0c\u6bcf\u5e74\u5438\u5f15\u4f86\u81ea\u5168\u7403100\u591a\u500b\u570b\u5bb6\u76841\u842c\u591a\u540d\u5c08\u696d\u4eba\u58eb\u8207\u6703\uff0c\u5206\u4eab\u5168\u7403\u6700\u524d\u6cbf\u7684\u7814\u7a76\u9032\u5c55\u548c\u7a81\u7834\u6027\u81e8\u5e8a\u6578\u64da\u3002\u4e9e\u76db\u91ab\u85e5\u9084\u5728\u672c\u5c46\u5927\u6703\u4e0a\u516c\u4f48\u4e86\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5291\u5967\u96f7\u5df4\u66ff\u5c3c\uff08\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b\u00ae\uff09\u3001EED\u6291\u5236\u5291APG-5918\u7684\u6700\u65b0\u7814\u7a76\u9032\u5c55\u3002 APG-2575\u5728\u6b64\u6b21EHA\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a Lisaftoclax (APG-2575) Combined with Novel Therapeutic Regimens in Patients (Pts) with Relapsed or Refractory (R\/R) Multiple Myeloma (MM) or Immunoglobulin Light-Chain (AL) Amyloidosis APG-2575\uff08Lisaftoclax\uff09\u806f\u5408\u65b0\u578b\u6cbb\u7642\u65b9\u6848\u7528\u65bc\u5fa9\u767c\/\u96e3\u6cbb\u6027\uff08R\/R\uff09\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08MM\uff09\u6216\u514d\u75ab\u7403\u86cb\u767d\u8f15\u93c8\uff08AL\uff09\u6fb1\u7c89\u6a23\u8b8a\u6027\u60a3\u8005 \u6458\u8981\u7de8\u865f\uff1aP917 \u5c55\u793a\u985e\u578b\uff1a\u58c1\u5831\u5c55\u793a \u5206\u6703\u5834\u6a19\u984c\uff1a\u9aa8\u9ad3\u7624\u53ca\u5176\u5b83\u55ae\u514b\u9686\u514d\u75ab\u7403\u86cb\u767d\u75c5 \u2013 \u81e8\u5e8a\u7814\u7a76 (Myeloma and other monoclonal gammopathies \u2013 Clinical) \u65e5\u671f\u53ca\u6642\u9593\uff1a2024\u5e746\u670814\u65e5\uff0c\u661f\u671f\u4e94 18:00 \u2013 19:00 (\u6b50\u6d32\u4e2d\u90e8\u6642\u9593) \/ 2024\u5e746\u670815\u65e5\uff0c\u661f\u671f\u516d 00:00 \u2013 01:00 (\u5317\u4eac\u6642\u9593) \u5831\u544a\u4eba\uff1aSikander Ailawadhi\u6559\u6388\uff0c\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3 \u6838\u5fc3\u8981\u9ede\uff1a \u7814\u7a76\u80cc\u666f\uff1aR\/R MM\u662f\u4e00\u7a2e\u96e3\u4ee5\u6cbb\u7652\u7684\u75be\u75c5\uff0c\u5982\u679c\u4e0d\u9032\u884c\u9069\u7576\u7684\u6cbb\u7642\u5e72\u9810\uff0c\u60a3\u8005\u5e7e\u4e4e\u90fd\u6703\u5fa9\u767c\u3002AL\u6fb1\u7c89\u6a23\u8b8a\u6027\u662f\u4e00\u7a2e\u7f55\u898b\u75be\u75c5\uff0c\u6703\u5c0e\u81f4\u56b4\u91cd\u7684\u5668\u5b98\u640d\u50b7\u6216\u6b7b\u4ea1\u3002APG-2575\u662f\u4e00\u7a2e\u65b0\u578b\u5f37\u6548\u7684\u3001\u9078\u64c7\u6027Bcl-2\u6291\u5236\u5291\uff0c\u5728\u8840\u6db2\u816b\u7624\u548c\u5be6\u9ad4\u816b\u7624\u6cbb\u7642\u4e2d\u5747\u5177\u6709\u81e8\u5e8a\u6f5b\u529b\uff0c\u4e26\u4e14\u5831\u544a\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08AEs\uff09\u767c\u751f\u7387\u8f03\u4f4e\u3002 \u7814\u7a76\u4ecb\u7d39\uff1a\u8a72\u9805\u591a\u4e2d\u5fc3\u81e8\u5e8a\u7814\u7a76\u65e8\u5728\u8a55\u4f30APG-2575\u806f\u5408\u6cca\u99ac\u5ea6\u80fa\u3001\u5730\u585e\u7c73\u677e\uff08A\u548cC\u7d44\uff09\u6216\u9054\u96f7\u59a5\u5c24\u55ae\u6297\u3001\u4f86\u90a3\u5ea6\u80fa\u3001\u5730\u585e\u7c73\u677e\uff08B\u7d44\uff09\u5206\u5225\u5728R\/R MM\uff08A\u548cB\u7d44\uff09\u6216R\/R AL\u6fb1\u7c89\u6a23\u8b8a\u6027\uff08C\u7d44\uff09\u60a3\u8005\u4e2d\u7684\u7642\u6548\u6027\u548c\u5b89\u5168\u6027\u3002 \u5165\u7d44\u60a3\u8005\u548c\u7814\u7a76\u65b9\u6cd5\uff1aECOG\u9ad4\u529b\u72c0\u6cc1\u8a55\u5206\u2264 2\u7684\u60a3\u8005\u63a5\u53d7\u4e86APG-2575\u6bcf\u65e5\u7d66\u85e5\uff0c28\u5929\/\u9031\u671f\u3002\u6cca\u99ac\u5ea6\u80fa\u3001\u9054\u96f7\u59a5\u5c24\u55ae\u6297\u3001\u4f86\u90a3\u5ea6\u80fa\u5747\u6309\u7167\u8aaa\u660e\u66f8\u4f7f\u7528\u65b9\u6cd5\u7d66\u85e5\u3002\u5730\u585e\u7c73\u677e\u7684\u7d66\u85e5\u5291\u91cf\u70ba40mg\/\u5929\uff0c\u5e74\u9f61>75\u6b72\u7684\u60a3\u8005\u6e1b\u91cf\u70ba20mg\/\u5929\u3002 \u622a\u81f32024\u5e741\u670825\u65e5\uff0c44\u4f8b\u60a3\u8005\u88ab\u7d0d\u5165\u7814\u7a76\uff0c\u5176\u4e2d36\u4f8bR\/R MM\u548c8\u4f8bR\/R AL\u6fb1\u7c89\u6a23\u8b8a\u6027\uff0c\u5206\u4f48\u5728\u4e09\u500b\u7d44\uff08A\u7d44\u3001B\u7d44\u548cC\u7d44\uff09\uff0c\u63a5\u53d7\u4e0d\u540c\u5291\u91cf\u7684APG-2575\u6cbb\u7642\uff1b \u60a3\u8005\u7684\u4e2d\u4f4d\u5e74\u9f61\u70ba70.5\u6b72\uff0824-88\u6b72\uff09\uff0c68.2%\u70ba\u7537\u6027\uff0c65.9%\u5e74\u9f61\u8d85\u904e65\u6b72\uff1b \u5148\u524d\u6cbb\u7642\u7dda\u6578\u7684\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u70ba3\uff081-19\uff09\uff0c\u5f9e\u8a3a\u65b7\u5230\u7814\u7a76\u85e5\u7269\u9996\u6b21\u5291\u91cf\u7684\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u6642\u9593\u70ba5.5\u5e74\uff081-29\u5e74\uff09\uff0c\u6cbb\u7642\u9031\u671f\u7684\u4e2d\u4f4d\uff08\u7bc4\u570d\uff09\u70ba4\uff081-26\uff09\u3002 \u7642\u6548\u6578\u64da\uff1a A\u7d44\u4e2d\uff0c27\u4f8bR\/R MM\u60a3\u8005\u53ef\u8a55\u4f30\u7642\u6548\uff0c\u5176\u4e2d10\u4f8b\u6709\u90e8\u5206\u7de9\u89e3\uff08PR\uff09\uff0c7\u4f8b\u975e\u5e38\u597d\u7684\u90e8\u5206\u7de9\u89e3\uff08VGPR\uff09\uff0c2\u4f8b\u5b8c\u5168\u7de9\u89e3\uff08CR\uff09\u3002\u7e3d\u7de9\u89e3\u7387\uff08ORR [PR+VGPR+CR]\uff09\u70ba70.4%\uff1b\u00a0 B\u7d44\u4e2d\uff0c2\u4f8bR\/R MM\u60a3\u8005\u9054\u5230CR\uff1b\u00a0 C\u7d44\u4e2d\uff0c\u67097\u4f8bR\/R AL\u6fb1\u7c89\u6a23\u8b8a\u6027\u60a3\u8005\u53ef\u4ee5\u8a55\u4f30\u7642\u6548\uff0cORR\u70ba85.7%\uff084\u4f8bVGPR\uff0c2\u4f8bCR\uff09\u3002 \u5b89\u5168\u6027\u6578\u64da\uff1a\u00a0 \u572842\u4f8b\u5b89\u5168\u6027\u5206\u6790\u4eba\u7fa4\u4e2d\uff0c10\u4f8b\u60a3\u8005\u5831\u544a\u4e86\u22653\u7d1a\u7684\u8207\u6cbb\u7642\u76f8\u95dc\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TRAEs\uff09\uff0c\u5305\u62ec\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\uff0814.3%\uff09\u548c\u767c\u71b1\u6027\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\uff082.4%\uff09\u7b49\u30023\u4f8b\u60a3\u8005\u767c\u751f\u56b4\u91cdTRAEs\uff0c\u767c\u71b1\u6027\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\u3001\u6025\u6027\u814e\u640d\u50b7\u548c\u8179\u7009\u53ca\u96fb\u89e3\u8cea\u5931\u8861\u54041\u4f8b\uff1b\u00a0 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