{"id":18357,"date":"2024-04-09T01:11:00","date_gmt":"2024-04-08T17:11:00","guid":{"rendered":"https:\/\/www.franchise.com.hk\/%e5%89%b5%e5%8b%9d%e9%9b%86%e5%9c%98%e5%ae%a3%e5%b8%83%e8%88%87%e5%ae%89%e6%8d%b7%e5%80%ab%e5%90%88%e4%bd%9c%e9%96%8b%e7%99%bc%e5%8f%af%e6%94%af%e6%8c%81osemitamabtst001%e5%85%a8%e7%90%83iii\/18357"},"modified":"2024-04-09T01:11:00","modified_gmt":"2024-04-08T17:11:00","slug":"%e5%89%b5%e5%8b%9d%e9%9b%86%e5%9c%98%e5%ae%a3%e5%b8%83%e8%88%87%e5%ae%89%e6%8d%b7%e5%80%ab%e5%90%88%e4%bd%9c%e9%96%8b%e7%99%bc%e5%8f%af%e6%94%af%e6%8c%81osemitamabtst001%e5%85%a8%e7%90%83iii","status":"publish","type":"post","link":"https:\/\/www.franchise.com.hk\/en\/%e5%89%b5%e5%8b%9d%e9%9b%86%e5%9c%98%e5%ae%a3%e5%b8%83%e8%88%87%e5%ae%89%e6%8d%b7%e5%80%ab%e5%90%88%e4%bd%9c%e9%96%8b%e7%99%bc%e5%8f%af%e6%94%af%e6%8c%81osemitamabtst001%e5%85%a8%e7%90%83iii\/18357","title":{"rendered":"\u5275\u52dd\u96c6\u5718\u5ba3\u5e03\u8207\u5b89\u6377\u502b\u5408\u4f5c\u958b\u767c\u53ef\u652f\u6301Osemitamab(TST001)\u5168\u7403III\u671f\u81e8\u5e8a\u8a66\u9a57\u7684Claudin18.2\u4f34\u96a8\u8a3a\u65b7\u8a66\u5291\u76d2"},"content":{"rendered":"<p><span class=\"legendSpanClass\">\u7f8e\u570b\u65b0\u6fa4\u897f\u5dde\u666e\u6797\u65af\u9813\u548c\u4e2d\u570b\u8607\u5dde<\/span><span class=\"legendSpanClass\">2024\u5e744\u67089\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u5275\u52dd\u96c6\u5718\uff0806628.HK\uff09\uff0c\u4e00\u5bb6\u5177\u5099\u751f\u7269\u85e5\u54c1\u767c\u73fe\u3001\u7814\u767c\u3001\u5de5\u85dd\u958b\u767c\u548c\u751f\u7522\u5168\u6d41\u7a0b\u6574\u5408\u80fd\u529b\u7684\u81e8\u5e8a\u968e\u6bb5\u7684\u751f\u7269\u5236\u85e5\u516c\u53f8\uff0c\u5ba3\u5e03\u8207\u5b89\u6377\u502b\u5408\u4f5c\u958b\u767cClaudin18.2(CLDN18.2)\u4f34\u96a8\u8a3a\u65b7\u8a66\u5291\uff0c\u4ee5\u652f\u6301Osemitamab (TST001)\u806f\u5408\u7d0d\u6b66\u5229\u5c24\u55ae\u6297\u8207\u5316\u7642\u4f5c\u70baCLDN18.2\u8868\u9054\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u80c3\u6216\u80c3\u98df\u7ba1\u7d50\u5408\u90e8(G\/GEJ)\u817a\u764c\u60a3\u8005\u4e00\u7dda\u6cbb\u7642\u7684TranStar301\u5168\u7403III\u671f\u95dc\u9375\u81e8\u5e8a\u8a66\u9a57\u3002<\/p>\n<p>\u5275\u52dd\u96c6\u5718\u7814\u767c\u51fa\u7684\u4e00\u7a2e\u6297CLDN18.2\u5c0f\u9f20\u55ae\u514b\u9686\u6297\u9ad4\uff1a14G11\u514b\u9686\uff0c\u53ef\u7279\u7570\u6027\u7d50\u5408CLDN18.2\uff0c\u800c\u4e0d\u7d50\u5408CLDN18.1\u3002\u8a72\u6297\u9ad4\u662f\u91dd\u5c0d\u4f4d\u65bcloop1\u7d30\u80de\u5916\u57df\u7684\u7dda\u6027\u8868\u4f4d\u751f\u6210\u7684\uff0c\u5176\u7d50\u5408\u4f4d\u9ede\u8207\u6cbb\u7642\u6027\u6297\u9ad4Osemitamab (TST001)\u7684\u7d50\u5408\u4f4d\u9ede\u91cd\u758a\u3002<\/p>\n<p>\u5275\u52dd\u96c6\u5718\u8207\u4f34\u96a8\u8a3a\u65b7\u958b\u767c\u9818\u57df\u7684\u5168\u7403\u9818\u5c0e\u8005\u5b89\u6377\u502b\u7dca\u5bc6\u5408\u4f5c\uff0c\u5171\u540c\u63a8\u9032\u8a72\u6297\u9ad4\u7684\u9032\u4e00\u6b65\u958b\u767c\u53ca\u5176\u5728\u4f34\u96a8\u8a3a\u65b7\u8a66\u5291\u4e2d\u7684\u61c9\u7528\u3002\u5b89\u6377\u502b\u6b63\u5728\u9032\u884c\u514d\u75ab\u7d44\u5316\uff08IHC\uff09\u8a66\u5291<span>Claudin18.2<\/span> IHC 14G11 pharmDx\u7684\u958b\u767c\uff0c\u7528\u65bc\u6aa2\u6e2c\u80c3\u6216\u80c3\u98df\u7ba1\u7d50\u5408\u90e8(G\/GEJ)\u817a\u764c\u4e2d\u7684CLDN18.2\u86cb\u767d\uff0c\u4e26\u6709\u53ef\u80fd\u7528\u65bc\u5176\u4ed6\u9069\u61c9\u75c7\u3002\u5b89\u6377\u502b\u8207\u5275\u52dd\u96c6\u5718\u5df2\u5728AACR\u5e74\u6703\u4e0a\u516c\u5e03\u4e86<span>Claudin18.2<\/span> IHC 14G11 pharmDx\u8a66\u5291\u7684\u65e9\u671f\u7814\u7a76\u7d50\u679c\u3002<span>Claudin18.2<\/span> IHC 14G11 pharmDx\uff08\u50c5\u7528\u65bc\u7814\u7a76\u7528\u9014\/\u50c5\u7528\u65bc\u6027\u80fd\u8a55\u4f30)\uff0c\u5c07\u7528\u65bc\u80c3\u6216\u80c3\u98df\u7ba1\u7d50\u5408\u90e8(G\/GEJ)\u817a\u764cIII\u671f\u8a66\u9a57\u7684\u60a3\u8005\u7be9\u9078\u4e26\u5df2\u7372\u5f97\u76f8\u61c9\u7684\u502b\u7406\u59d4\u54e1\u6703\u548c\u76e3\u7ba1\u6279\u51c6\u3002<\/p>\n<p>\u300c\u9452\u65bc\u5b89\u6377\u502b\u5728\u4ee5\u5f80\u7cbe\u51c6\u816b\u7624\u5b78\u9818\u57df\u958b\u767c\u4f34\u96a8\u8a3a\u65b7\u7684\u8c50\u5bcc\u7d93\u9a57\uff0c\u5176\u5728\u4f34\u96a8\u8a3a\u65b7\u958b\u767c\u65b9\u9762\u7684\u5c08\u696d\u5ea6\u4ee4\u4eba\u5370\u8c61\u6df1\u523b\uff0c\u300d\u5275\u52dd\u96c6\u5718\u5168\u7403\u85e5\u7269\u958b\u767c\u57f7\u884c\u526f\u7e3d\u88c1\uff0c\u9996\u5e2d\u91ab\u5b78\u5b98Caroline Germa\u535a\u58eb\u8868\u793a, \u300c\u5f88\u9ad8\u8208\u80fd\u9054\u6210\u6b64\u6b21\u5408\u4f5c\uff0c\u671f\u5f85\u651c\u624b\u6539\u5584\u60a3\u8005\u9810\u5f8c\uff0c\u5171\u8b00\u60a3\u8005\u798f\u7949\u3002\u300d<\/p>\n<p>\u300c\u5f88\u9ad8\u8208\u80fd\u8207\u5275\u52dd\u96c6\u5718\u5408\u4f5c\u958b\u767c<span>Claudin18.2<\/span> IHC 14G11 pharmDx\u4f34\u96a8\u8a3a\u65b7\u8a66\u5291\uff0c\u300d\u5b89\u6377\u502b\u526f\u7e3d\u88c1\u517c\u4f34\u96a8\u8a3a\u65b7\u90e8\u9580\u7e3d\u7d93\u7406Paul Beresford\u535a\u58eb\u8868\u793a\uff0c\u300c\u8a72\u5408\u4f5c\u5c07\u70ba\u80c3\u6216\u80c3\u98df\u7ba1\u7d50\u5408\u90e8(G\/GEJ)\u817a\u764c\u60a3\u8005\u63d0\u4f9b\u66f4\u7cbe\u51c6\u7684\u91ab\u7642\u7522\u54c1\uff0c\u9032\u800c\u6539\u5584\u8a3a\u65b7\u3001\u6cbb\u7642\u548c\u60a3\u8005\u5065\u5eb7\u3002\u300d<\/p>\n<p>\u95dc\u65bcOsemitamab (TST001)<\/p>\n<p>Osemitamab (TST001) \u662f\u4e00\u7a2e\u9ad8\u89aa\u548c\u529b\u7684\u9776\u5411CLDN18.2\u7684\u4eba\u6e90\u5316\u55ae\u514b\u9686\u6297\u9ad4\uff0c\u5177\u6709\u589e\u5f37\u7684\u6297\u9ad4\u4f9d\u8cf4\u6027\u7d30\u80de\u6bd2\u6027\uff08ADCC\uff09\uff0c\u5728\u7570\u7a2e\u79fb\u690d\u8a66\u9a57\u4e2d\u986f\u793a\u51fa\u5f37\u5927\u7684\u6297\u816b\u7624\u6d3b\u6027\u3002Osemitamab (TST001) \u662f\u5168\u7403\u8303\u570d\u5167\u958b\u767c\u7684\u7b2c\u4e8c\u500b\u6700\u5148\u9032\u7684CLDN18.2\u9776\u5411\u6297\u9ad4\u85e5\u7269\uff0c\u7531\u672c\u516c\u53f8\u901a\u904e\u5176\u514d\u75ab\u8010\u53d7\u7a81\u7834(IMTB)\u6280\u8853\u5e73\u53f0\u958b\u767c\u3002Osemitamab (TST001) \u901a\u904eADCC\u6a5f\u5236\u6bba\u6b7b\u8868\u9054CLDN18.2\u7684\u816b\u7624\u7d30\u80de\u3002\u5229\u7528\u5148\u9032\u7684\u751f\u7269\u52a0\u5de5\u6280\u8853\uff0cOsemitamab (TST001) \u7684\u5dd6\u85fb\u7cd6\u542b\u91cf\u5728\u751f\u7522\u904e\u7a0b\u4e2d\u5927\u5927\u964d\u4f4e\uff0c\u9032\u4e00\u6b65\u589e\u5f37\u4e86Osemitamab (TST001) \u7684NK\u7d30\u80de\u4ecb\u5c0e\u7684ADCC\u6d3b\u6027\u3002\u4e2d\u570b\u548c\u7f8e\u570b\u5747\u4e00\u76f4\u5728\u9032\u884cOsemitamab (TST001) \u7684\u81e8\u5e8a\u8a66\u9a57(NCT05190575\u3001NCT04396821\u3001NCT04495296\u3001NCT05608785 \/ CTR20201281)\u3002\u7f8e\u570b\u98df\u54c1\u548c\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40(FDA)\u5df2\u6388\u4e88Osemitamab (TST001) \u7528\u65bc\u6cbb\u7642\u80c3\u764c\u6216\u80c3\u98df\u7ba1\u7d50\u5408\u90e8\u817a\u764c\u548c\u80f0\u817a\u764c\u60a3\u8005\u7684\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\u3002<\/p>\n<p>\u95dc\u65bc\u5275\u52dd\u96c6\u5718<\/p>\n<p>\u5275\u52dd\u96c6\u5718\u662f\u4e00\u5bb6\u81e8\u5e8a\u968e\u6bb5\u7684\u5728\u751f\u7269\u85e5\u767c\u73fe\u3001\u7814\u767c\u3001\u5de5\u85dd\u958b\u767c\u548c\u751f\u7522\u65b9\u9762\u5177\u6709\u5168\u9762\u7d9c\u5408\u80fd\u529b\u7684\u751f\u7269\u5236\u85e5\u516c\u53f8\u3002<\/p>\n<p>\u5275\u52dd\u96c6\u5718\u7e3d\u90e8\u4f4d\u65bc\u8607\u5dde\uff0c\u5df2\u6210\u529f\u642d\u5efa\u4e86\u5168\u7403\u7684\u696d\u52d9\u5e03\u5c40\uff1a\u5728\u8607\u5dde\u8a2d\u6709\u85e5\u7269\u767c\u73fe\u3001\u81e8\u5e8a\u548c\u8f49\u5316\u7814\u7a76\u4e2d\u5fc3\uff0c\u5275\u52dd\u96c6\u5718\u7e3d\u90e8\u53ca\u4ee5\u9023\u7e8c\u704c\u6d41\u751f\u7522\u5de5\u85dd\u70ba\u6838\u5fc3\u6280\u8853\u7684\u751f\u7522\u57fa\u5730\u4e5f\u6b63\u5728\u5efa\u8a2d\u4e2d\u3002\u5728\u676d\u5dde\u64c1\u6709\u5de5\u85dd\u8207\u7522\u54c1\u958b\u767c\u4e2d\u5fc3\u4ee5\u53ca\u85e5\u7269\u751f\u7522\u57fa\u5730\uff0c\u5728\u7f8e\u570b\u666e\u6797\u65af\u9813\u3001\u5317\u4eac\u3001\u4e0a\u6d77\u3001\u5ee3\u5dde\u5206\u5225\u8a2d\u6709\u81e8\u5e8a\u958b\u767c\u4e2d\u5fc3\uff0c\u4e26\u5728\u7f8e\u570b\u6ce2\u58eb\u9813\u3001\u6d1b\u6749\u78ef\u8a2d\u7acb\u4e86\u696d\u52d9\u62d3\u5c55\u4e2d\u5fc3\u3002\u5275\u52dd\u96c6\u5718\u7684\u958b\u767c\u7ba1\u7dda\u5df2\u6709\u5341\u4e09\u500b\u6cbb\u7642\u7528\u6297\u9ad4\u65b0\u85e5\u5206\u5b50\uff0c\u6db5\u84cb\u816b\u7624\u3001\u9aa8\u79d1\u548c\u814e\u75c5\u7b49\u9818\u57df\u3002<\/p>\n<p>\u5982\u9700\u4e86\u89e3\u95dc\u65bc\u5275\u52dd\u96c6\u5718\u7684\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\u516c\u53f8\u7db2\u7ad9\uff1a<a href=\"https:\/\/www.transcenta.com\/\" target=\"_blank\" rel=\"noopener\">www.transcenta.com<\/a>\u6216\u9818\u82f1\u8cec\u865f\uff1aTranscenta\u3002<\/p>","protected":false},"excerpt":{"rendered":"<p>\u7f8e\u570b\u65b0\u6fa4\u897f\u5dde\u666e\u6797\u65af\u9813\u548c\u4e2d\u570b\u8607\u5dde2024\u5e744\u67089\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u5275\u52dd\u96c6\u5718\uff0806628.HK\uff09\uff0c\u4e00\u5bb6\u5177\u5099\u751f\u7269\u85e5\u54c1\u767c\u73fe\u3001\u7814\u767c\u3001\u5de5\u85dd\u958b\u767c\u548c\u751f\u7522\u5168\u6d41\u7a0b\u6574\u5408\u80fd\u529b\u7684\u81e8\u5e8a\u968e\u6bb5\u7684\u751f\u7269\u5236\u85e5\u516c\u53f8\uff0c\u5ba3\u5e03\u8207\u5b89\u6377\u502b\u5408\u4f5c\u958b\u767cClaudin18.2(CLDN18.2)\u4f34\u96a8\u8a3a\u65b7\u8a66\u5291\uff0c\u4ee5\u652f\u6301Osemitamab (TST001)\u806f\u5408\u7d0d\u6b66\u5229\u5c24\u55ae\u6297\u8207\u5316\u7642\u4f5c\u70baCLDN18.2\u8868\u9054\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u80c3\u6216\u80c3\u98df\u7ba1\u7d50\u5408\u90e8(G\/GEJ)\u817a\u764c\u60a3\u8005\u4e00\u7dda\u6cbb\u7642\u7684TranStar301\u5168\u7403III\u671f\u95dc\u9375\u81e8\u5e8a\u8a66\u9a57\u3002 \u5275\u52dd\u96c6\u5718\u7814\u767c\u51fa\u7684\u4e00\u7a2e\u6297CLDN18.2\u5c0f\u9f20\u55ae\u514b\u9686\u6297\u9ad4\uff1a14G11\u514b\u9686\uff0c\u53ef\u7279\u7570\u6027\u7d50\u5408CLDN18.2\uff0c\u800c\u4e0d\u7d50\u5408CLDN18.1\u3002\u8a72\u6297\u9ad4\u662f\u91dd\u5c0d\u4f4d\u65bcloop1\u7d30\u80de\u5916\u57df\u7684\u7dda\u6027\u8868\u4f4d\u751f\u6210\u7684\uff0c\u5176\u7d50\u5408\u4f4d\u9ede\u8207\u6cbb\u7642\u6027\u6297\u9ad4Osemitamab (TST001)\u7684\u7d50\u5408\u4f4d\u9ede\u91cd\u758a\u3002 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