{"id":16364,"date":"2023-12-05T08:50:00","date_gmt":"2023-12-05T00:50:00","guid":{"rendered":"https:\/\/www.franchise.com.hk\/%e6%ad%8c%e7%a6%ae%e5%ae%a3%e5%b8%83%e5%95%9f%e5%8b%95asc40%ef%bc%88%e5%9c%b0%e5%b0%bc%e6%b3%95%e5%8f%b8%e4%bb%96%ef%bc%89%e6%b2%bb%e7%99%82%e7%97%a4%e7%98%a1%e2%85%a2%e6%9c%9f%e8%87%a8%e5%ba%8a\/16364"},"modified":"2023-12-05T08:50:00","modified_gmt":"2023-12-05T00:50:00","slug":"%e6%ad%8c%e7%a6%ae%e5%ae%a3%e5%b8%83%e5%95%9f%e5%8b%95asc40%ef%bc%88%e5%9c%b0%e5%b0%bc%e6%b3%95%e5%8f%b8%e4%bb%96%ef%bc%89%e6%b2%bb%e7%99%82%e7%97%a4%e7%98%a1%e2%85%a2%e6%9c%9f%e8%87%a8%e5%ba%8a","status":"publish","type":"post","link":"https:\/\/www.franchise.com.hk\/en\/%e6%ad%8c%e7%a6%ae%e5%ae%a3%e5%b8%83%e5%95%9f%e5%8b%95asc40%ef%bc%88%e5%9c%b0%e5%b0%bc%e6%b3%95%e5%8f%b8%e4%bb%96%ef%bc%89%e6%b2%bb%e7%99%82%e7%97%a4%e7%98%a1%e2%85%a2%e6%9c%9f%e8%87%a8%e5%ba%8a\/16364","title":{"rendered":"\u6b4c\u79ae\u5ba3\u5e03\u555f\u52d5ASC40\uff08\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff09\u6cbb\u7642\u75e4\u7621\u2162\u671f\u81e8\u5e8a\u8a66\u9a57"},"content":{"rendered":"

–ASC40\u6cbb\u7642\u4e2d\u3001\u91cd\u5ea6\u5c0b\u5e38\u6027\u75e4\u7621\u7684\u2162\u671f\u81e8\u5e8a\u8a66\u9a57\u5c07\u5165\u7d44480\u4f8b\u53d7\u8a66\u8005<\/p>\n

–III\u671f\u81e8\u5e8a\u8a66\u9a57\u65b9\u6848\u5df2\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\u540c\u610f\uff0c\u4e26\u5df2\u7372\u5f97\u5fa9\u65e6\u5927\u5b78\u9644\u5c6c\u83ef\u5c71\u91ab\u9662\u6a5f\u69cb\u502b\u7406\u59d4\u54e1\u6703\u6279\u51c6\u00a0<\/p>\n

–\u5fa9\u65e6\u5927\u5b78\u9644\u5c6c\u83ef\u5c71\u91ab\u9662\u9805\u857e\u7d05\u6559\u6388\u64d4\u4efb\u9019\u9805III\u671f\u81e8\u5e8a\u8a66\u9a57\u7684\u4e3b\u8981\u7814\u7a76\u8005<\/p>\n

\u676d\u5dde\u548c\u7d39\u8208<\/span>2023\u5e7412\u67085\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u6b4c\u79ae\u5236\u85e5\u6709\u9650\u516c\u53f8\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a1672\uff0c\u300c\u6b4c\u79ae\u300d\uff09\u4eca\u65e5\u5ba3\u5e03\u555f\u52d5\u8102\u80aa\u9178\u5408\u6210\u9176\uff08FASN\uff09\u6291\u5236\u5291ASC40\uff08\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff09\u6cbb\u7642\u4e2d\u3001\u91cd\u5ea6\u5c0b\u5e38\u6027\u75e4\u7621\u7684III\u671f\u81e8\u5e8a\u8a66\u9a57\u3002\u00a0<\/p>\n

\u9019\u9805III\u671f\u81e8\u5e8a\u8a66\u9a57\u662f\u4e00\u9805\u5728\u4e2d\u570b\u958b\u5c55\u7684\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u3001\u591a\u4e2d\u5fc3\u7684\u81e8\u5e8a\u8a66\u9a57\uff0c\u65e8\u5728\u8a55\u4f30ASC40\u6cbb\u7642\u4e2d\u3001\u91cd\u5ea6\u5c0b\u5e38\u6027\u75e4\u7621\u7684\u5b89\u5168\u6027\u548c\u7642\u6548\u3002480\u4f8b\u4e2d\u3001\u91cd\u5ea6\u5c0b\u5e38\u6027\u75e4\u7621\u53d7\u8a66\u8005\u5c07\u88ab\u6309\u71671:1\u7684\u6bd4\u4f8b\u96a8\u6a5f\u5206\u81f3\u4e00\u500b\u6d3b\u6027\u85e5\u7269\u7d44\u548c\u4e00\u500b\u5b89\u6170\u5291\u5c0d\u7167\u7d44\uff0c\u63a5\u53d7\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d50\u6beb\u514bASC40\u6216\u5339\u914d\u7684\u5b89\u6170\u5291\u6cbb\u7642\uff0c\u70ba\u671f12\u5468\u3002<\/p>\n

\u4e3b\u8981\u7642\u6548\u7d42\u9ede\u70ba\uff1a\u7b2c12\u5468\u6642\uff0c\u6cbb\u7642\u6210\u529f\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\uff0c\u53d7\u8a66\u8005\u7e3d\u76ae\u640d\u8a08\u6578\u76f8\u5c0d\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316\uff0c\u4ee5\u53ca\u53d7\u8a66\u8005\u708e\u6027\u76ae\u640d\u8a08\u6578\u76f8\u5c0d\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316\u3002\u6cbb\u7642\u6210\u529f\u7684\u5b9a\u7fa9\u70ba\uff1a\u7814\u7a76\u8005\u7e3d\u9ad4\u8a55\u4f30\uff08IGA\uff09\u8a55\u5206\u8f03\u57fa\u7dda\u4e0b\u964d\u22652\u5206\uff0c\u4e14IGA\u5206\u7d1a\u70ba\u5149\u6f54\uff080\u5206\uff09\u6216\u5e7e\u4e4e\u5149\u6f54\uff081\u5206\uff09\u3002<\/p>\n

III\u671f\u81e8\u5e8a\u8a66\u9a57\u65b9\u6848\u5df2\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\u540c\u610f\uff0c\u4e26\u5df2\u7372\u5f97\u5fa9\u65e6\u5927\u5b78\u9644\u5c6c\u83ef\u5c71\u91ab\u9662\u6a5f\u69cb\u502b\u7406\u59d4\u54e1\u6703\u6279\u51c6\u3002<\/p>\n

2023\u5e745\u67082\u65e5\uff0c\u6b4c\u79ae\u5ba3\u5e03ASC40\u6cbb\u7642\u5c0b\u5e38\u6027\u75e4\u7621\u7684II\u671f\u81e8\u5e8a\u8a66\u9a57\u9054\u5230\u4e3b\u8981\u53ca\u95dc\u9375\u6b21\u8981\u7d42\u9ede\uff0c\u8868\u73fe\u51fa\u4e86\u986f\u8457\u7684\u7642\u6548\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u3002<\/p>\n

ASC40\u662f\u4e00\u7a2e\u53e3\u670d\u3001\u9078\u64c7\u6027\u5c0f\u5206\u5b50FASN\u6291\u5236\u5291\u3002ASC40\u6cbb\u7642\u75e4\u7621\u7684\u6a5f\u5236\u662f\uff1a\uff081\uff09\u901a\u904e\u6291\u5236\u4eba\u76ae\u8102\u7d30\u80de\u7684\u8102\u80aa\u9178\u5f9e\u982d\u5408\u6210\uff08DNL\uff09\uff0c\u76f4\u63a5\u6291\u5236\u9762\u90e8\u76ae\u8102\u751f\u6210\uff1b\u548c\uff082\uff09\u901a\u904e\u6e1b\u5c11\u7d30\u80de\u56e0\u5b50\u5206\u6ccc\u548cTh17\u5206\u5316\u4f86\u6291\u5236\u708e\u75c7\u3002\u6b4c\u79ae\u5df2\u5f9eSagimet Biosciences Inc.\u7372\u5f97ASC40\u5728\u5927\u4e2d\u83ef\u5340\u7684\u958b\u767c\u3001\u751f\u7522\u548c\u5546\u696d\u5316\u7368\u5bb6\u6b0a\u76ca\u3002<\/p>\n

\u75e4\u7621\u662f\u5168\u7403\u7b2c\u516b\u5927\u5e38\u898b\u75be\u75c5\uff0c\u5f71\u97ff\u5168\u7403\u8d85\u904e6.4\u5104\u4eba[1]\u3002\u8207\u53e3\u670d\u85e5\u7269\u76f8\u6bd4\uff0c\u5916\u7528\u7642\u6cd5\u7684\u4f9d\u5f9e\u6027\u66f4\u4f4e\uff1a\u64da\u4f30\u8a08\uff0c\u7d04\u670930%\u81f340%\u7684\u60a3\u8005\u7121\u6cd5\u5805\u6301\u5916\u7528\u6cbb\u7642[2]\u3002\u76ee\u524d\uff0c\u6709\u6548\u7684\u53e3\u670d\u75e4\u7621\u85e5\u7269\u4e3b\u8981\u662f\u7570\u7dadA\u9178\uff0c\u5176\u53ef\u80fd\u6703\u5c0e\u81f4\u8a31\u591a\u56b4\u91cd\u7684\u4e0d\u826f\u4e8b\u4ef6\uff0c\u5982\u809d\u6bd2\u6027\u3001\u807d\u529b\u969c\u7919\u548c\u6291\u90c1\u75c7\u7b49\u3002ASC40\u6709\u671b\u6210\u70ba\u540c\u985e\u9996\u5275\u3001\u6bcf\u65e5\u4e00\u6b21\u3001\u60a3\u8005\u4f9d\u5f9e\u6027\u9ad8\u7684\u53e3\u670d\u75e4\u7621\u85e5\u7269\u3002<\/p>\n

\u300c\u75e4\u7621\u6cbb\u7642\u7f3a\u4e4f\u65b0\u85e5\u4e0a\u5e02\uff0cASC40\u662f\u5177\u6709\u5168\u65b0\u4f5c\u7528\u6a5f\u5236\u7684\u53e3\u670d\u75e4\u7621\u5019\u9078\u85e5\u7269\u3002\u300d\u5fa9\u65e6\u5927\u5b78\u9644\u5c6c\u83ef\u5c71\u91ab\u9662\u76ae\u819a\u79d1\u4e3b\u4efb\u91ab\u5e2b\uff0c\u5fa9\u65e6\u5927\u5b78\u76ae\u819a\u75c5\u5b78\u7814\u7a76\u6240\u5e38\u52d9\u526f\u6240\u9577\uff0c\u4e2d\u570b\u91ab\u5e2b\u5354\u6703\u76ae\u819a\u79d1\u91ab\u5e2b\u5206\u6703\u526f\u6703\u9577\uff0cASC40\u4e2d\u3001\u91cd\u5ea6\u75e4\u7621III\u671f\u81e8\u5e8a\u8a66\u9a57\u4e3b\u8981\u7814\u7a76\u8005\u9805\u857e\u7d05\u6559\u6388\u8868\u793a\u3002<\/p>\n

\u300c\u5f88\u9ad8\u8208\u6b4c\u79ae\u53d6\u5f97\u4e86\u53c8\u4e00\u500b\u88e1\u7a0b\u7891\uff0c\u5f70\u986f\u4e86\u6211\u5011\u628a\u7ba1\u7dda\u9805\u76ee\u5feb\u901f\u63a8\u9032\u5230\u81e8\u5e8a\u5f8c\u671f\u7684\u5353\u8d8a\u57f7\u884c\u529b\u3002\u4f5c\u70ba\u540c\u985e\u9996\u5275\u3001\u64c1\u6709\u6cbb\u7642\u75e4\u7621\u65b0\u578b\u4f5c\u7528\u6a5f\u5236\u7684\u5019\u9078\u85e5\u7269\uff0cASC40\u5728II\u671f\u7814\u7a76\u4e2d\u8868\u73fe\u51fa\u4e86\u986f\u8457\u7684\u7642\u6548\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u3002\u6211\u5011\u76f8\u4fe1\uff0c\u5168\u65b0\u7684\u4f5c\u7528\u6a5f\u5236\u5c07\u6709\u52a9\u65bcASC40\u6210\u70ba\u6cbb\u7642\u4e2d\u3001\u91cd\u5ea6\u75e4\u7621\u5b89\u5168\u4e14\u6709\u6548\u7684\u65b9\u6848\u3002\u300d\u6b4c\u79ae\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u6703\u4e3b\u5e2d\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u5433\u52c1\u6893\u535a\u58eb\u8868\u793a\u3002<\/p>\n

[1]Tan J K, Bhate K. A global perspective on the epidemiology of acne [J]. Br J Dermatol 2015, 172 Suppl 1(3-12). DOI: 10.1111\/bjd.13462.<\/p>\n

[2]Purvis CG, Balogh EA, Feldman SR. Clascoterone: How the Novel Androgen Receptor Inhibitor Fits Into the Acne Treatment Paradigm. Ann Pharmacother. 2021;55(10):1297-1299. doi:10.1177\/1060028021992055.<\/p>\n

\u95dc\u65bc\u6b4c\u79ae<\/p>\n

\u6b4c\u79ae\u662f\u4e00\u5bb6\u5728\u9999\u6e2f\u8b49\u5238\u4ea4\u6613\u6240\u4e0a\u5e02\uff081672.HK\uff09\u7684\u5275\u65b0\u7814\u767c\u9a45\u52d5\u578b\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u6db5\u84cb\u4e86\u5f9e\u65b0\u85e5\u7814\u767c\u81f3\u751f\u7522\u548c\u5546\u696d\u5316\u7684\u5b8c\u6574\u50f9\u503c\u93c8\u3002\u6b4c\u79ae\u7684\u7ba1\u7406\u5718\u968a\u5177\u5099\u6df1\u539a\u7684\u5c08\u696d\u77e5\u8b58\u53ca\u512a\u79c0\u7684\u904e\u5f80\u6210\u5c31\uff0c\u5728\u5718\u968a\u7684\u5e36\u9818\u4e0b\uff0c\u6b4c\u79ae\u805a\u7126\u4e09\u5927\u81e8\u5e8a\u9700\u6c42\u5c1a\u672a\u6eff\u8db3\u7684\u91ab\u7642\u9818\u57df\uff1a\u75c5\u6bd2\u6027\u75be\u75c5\u3001\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\u548c\u816b\u7624\uff0c\u4e26\u4ee5\u5168\u7403\u5316\u7684\u8996\u91ce\u9032\u884c\u5e03\u5c40\u3002\u6191\u501f\u5353\u8d8a\u7684\u57f7\u884c\u529b\uff0c\u6b4c\u79ae\u5feb\u901f\u63a8\u9032\u85e5\u7269\u7ba1\u7dda\u958b\u767c\uff0c\u722d\u53d6\u5728\u570b\u969b\u7af6\u722d\u4e2d\u5360\u64da\u9818\u5148\u5730\u4f4d\u3002\u6b4c\u79ae\u76ee\u524d\u64c1\u6709\u591a\u6b3e\u5728\u7814\u85e5\u7269, \u6700\u524d\u6cbf\u7684\u5019\u9078\u85e5\u7269\u5305\u62ecASC22\uff08\u4e59\u809d\u529f\u80fd\u6027\u6cbb\u6108\uff09\u3001ASC40\uff08\u75e4\u7621\uff09\u3001ASC40\uff08\u5fa9\u767c\u6027\u81a0\u8cea\u6bcd\u7d30\u80de\u7624\uff09\u3001ASC40(\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e)\u3001ASC41(\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e)\u53caASC61\uff08\u665a\u671f\u5be6\u9ad4\u7624\uff09\u3002<\/p>\n

\u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8acb\u767b\u9304\u7db2\u7ad9\uff1awww.ascletis.com<\/a>\u3002<\/p>","protected":false},"excerpt":{"rendered":"

–ASC40\u6cbb\u7642\u4e2d\u3001\u91cd\u5ea6\u5c0b\u5e38\u6027\u75e4\u7621\u7684\u2162\u671f\u81e8\u5e8a\u8a66\u9a57\u5c07\u5165\u7d44480\u4f8b\u53d7\u8a66\u8005 –III\u671f\u81e8\u5e8a\u8a66\u9a57\u65b9\u6848\u5df2\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\u540c\u610f\uff0c\u4e26\u5df2\u7372\u5f97\u5fa9\u65e6\u5927\u5b78\u9644\u5c6c\u83ef\u5c71\u91ab\u9662\u6a5f\u69cb\u502b\u7406\u59d4\u54e1\u6703\u6279\u51c6\u00a0 –\u5fa9\u65e6\u5927\u5b78\u9644\u5c6c\u83ef\u5c71\u91ab\u9662\u9805\u857e\u7d05\u6559\u6388\u64d4\u4efb\u9019\u9805III\u671f\u81e8\u5e8a\u8a66\u9a57\u7684\u4e3b\u8981\u7814\u7a76\u8005 \u676d\u5dde\u548c\u7d39\u82082023\u5e7412\u67085\u65e5 \/\u7f8e\u901a\u793e\/ — \u6b4c\u79ae\u5236\u85e5\u6709\u9650\u516c\u53f8\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a1672\uff0c\u300c\u6b4c\u79ae\u300d\uff09\u4eca\u65e5\u5ba3\u5e03\u555f\u52d5\u8102\u80aa\u9178\u5408\u6210\u9176\uff08FASN\uff09\u6291\u5236\u5291ASC40\uff08\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff09\u6cbb\u7642\u4e2d\u3001\u91cd\u5ea6\u5c0b\u5e38\u6027\u75e4\u7621\u7684III\u671f\u81e8\u5e8a\u8a66\u9a57\u3002\u00a0 \u9019\u9805III\u671f\u81e8\u5e8a\u8a66\u9a57\u662f\u4e00\u9805\u5728\u4e2d\u570b\u958b\u5c55\u7684\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u3001\u591a\u4e2d\u5fc3\u7684\u81e8\u5e8a\u8a66\u9a57\uff0c\u65e8\u5728\u8a55\u4f30ASC40\u6cbb\u7642\u4e2d\u3001\u91cd\u5ea6\u5c0b\u5e38\u6027\u75e4\u7621\u7684\u5b89\u5168\u6027\u548c\u7642\u6548\u3002480\u4f8b\u4e2d\u3001\u91cd\u5ea6\u5c0b\u5e38\u6027\u75e4\u7621\u53d7\u8a66\u8005\u5c07\u88ab\u6309\u71671:1\u7684\u6bd4\u4f8b\u96a8\u6a5f\u5206\u81f3\u4e00\u500b\u6d3b\u6027\u85e5\u7269\u7d44\u548c\u4e00\u500b\u5b89\u6170\u5291\u5c0d\u7167\u7d44\uff0c\u63a5\u53d7\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d50\u6beb\u514bASC40\u6216\u5339\u914d\u7684\u5b89\u6170\u5291\u6cbb\u7642\uff0c\u70ba\u671f12\u5468\u3002 \u4e3b\u8981\u7642\u6548\u7d42\u9ede\u70ba\uff1a\u7b2c12\u5468\u6642\uff0c\u6cbb\u7642\u6210\u529f\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\uff0c\u53d7\u8a66\u8005\u7e3d\u76ae\u640d\u8a08\u6578\u76f8\u5c0d\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316\uff0c\u4ee5\u53ca\u53d7\u8a66\u8005\u708e\u6027\u76ae\u640d\u8a08\u6578\u76f8\u5c0d\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316\u3002\u6cbb\u7642\u6210\u529f\u7684\u5b9a\u7fa9\u70ba\uff1a\u7814\u7a76\u8005\u7e3d\u9ad4\u8a55\u4f30\uff08IGA\uff09\u8a55\u5206\u8f03\u57fa\u7dda\u4e0b\u964d\u22652\u5206\uff0c\u4e14IGA\u5206\u7d1a\u70ba\u5149\u6f54\uff080\u5206\uff09\u6216\u5e7e\u4e4e\u5149\u6f54\uff081\u5206\uff09\u3002 III\u671f\u81e8\u5e8a\u8a66\u9a57\u65b9\u6848\u5df2\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\u540c\u610f\uff0c\u4e26\u5df2\u7372\u5f97\u5fa9\u65e6\u5927\u5b78\u9644\u5c6c\u83ef\u5c71\u91ab\u9662\u6a5f\u69cb\u502b\u7406\u59d4\u54e1\u6703\u6279\u51c6\u3002 2023\u5e745\u67082\u65e5\uff0c\u6b4c\u79ae\u5ba3\u5e03ASC40\u6cbb\u7642\u5c0b\u5e38\u6027\u75e4\u7621\u7684II\u671f\u81e8\u5e8a\u8a66\u9a57\u9054\u5230\u4e3b\u8981\u53ca\u95dc\u9375\u6b21\u8981\u7d42\u9ede\uff0c\u8868\u73fe\u51fa\u4e86\u986f\u8457\u7684\u7642\u6548\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u3002 ASC40\u662f\u4e00\u7a2e\u53e3\u670d\u3001\u9078\u64c7\u6027\u5c0f\u5206\u5b50FASN\u6291\u5236\u5291\u3002ASC40\u6cbb\u7642\u75e4\u7621\u7684\u6a5f\u5236\u662f\uff1a\uff081\uff09\u901a\u904e\u6291\u5236\u4eba\u76ae\u8102\u7d30\u80de\u7684\u8102\u80aa\u9178\u5f9e\u982d\u5408\u6210\uff08DNL\uff09\uff0c\u76f4\u63a5\u6291\u5236\u9762\u90e8\u76ae\u8102\u751f\u6210\uff1b\u548c\uff082\uff09\u901a\u904e\u6e1b\u5c11\u7d30\u80de\u56e0\u5b50\u5206\u6ccc\u548cTh17\u5206\u5316\u4f86\u6291\u5236\u708e\u75c7\u3002\u6b4c\u79ae\u5df2\u5f9eSagimet Biosciences Inc.\u7372\u5f97ASC40\u5728\u5927\u4e2d\u83ef\u5340\u7684\u958b\u767c\u3001\u751f\u7522\u548c\u5546\u696d\u5316\u7368\u5bb6\u6b0a\u76ca\u3002 \u75e4\u7621\u662f\u5168\u7403\u7b2c\u516b\u5927\u5e38\u898b\u75be\u75c5\uff0c\u5f71\u97ff\u5168\u7403\u8d85\u904e6.4\u5104\u4eba[1]\u3002\u8207\u53e3\u670d\u85e5\u7269\u76f8\u6bd4\uff0c\u5916\u7528\u7642\u6cd5\u7684\u4f9d\u5f9e\u6027\u66f4\u4f4e\uff1a\u64da\u4f30\u8a08\uff0c\u7d04\u670930%\u81f340%\u7684\u60a3\u8005\u7121\u6cd5\u5805\u6301\u5916\u7528\u6cbb\u7642[2]\u3002\u76ee\u524d\uff0c\u6709\u6548\u7684\u53e3\u670d\u75e4\u7621\u85e5\u7269\u4e3b\u8981\u662f\u7570\u7dadA\u9178\uff0c\u5176\u53ef\u80fd\u6703\u5c0e\u81f4\u8a31\u591a\u56b4\u91cd\u7684\u4e0d\u826f\u4e8b\u4ef6\uff0c\u5982\u809d\u6bd2\u6027\u3001\u807d\u529b\u969c\u7919\u548c\u6291\u90c1\u75c7\u7b49\u3002ASC40\u6709\u671b\u6210\u70ba\u540c\u985e\u9996\u5275\u3001\u6bcf\u65e5\u4e00\u6b21\u3001\u60a3\u8005\u4f9d\u5f9e\u6027\u9ad8\u7684\u53e3\u670d\u75e4\u7621\u85e5\u7269\u3002 \u300c\u75e4\u7621\u6cbb\u7642\u7f3a\u4e4f\u65b0\u85e5\u4e0a\u5e02\uff0cASC40\u662f\u5177\u6709\u5168\u65b0\u4f5c\u7528\u6a5f\u5236\u7684\u53e3\u670d\u75e4\u7621\u5019\u9078\u85e5\u7269\u3002\u300d\u5fa9\u65e6\u5927\u5b78\u9644\u5c6c\u83ef\u5c71\u91ab\u9662\u76ae\u819a\u79d1\u4e3b\u4efb\u91ab\u5e2b\uff0c\u5fa9\u65e6\u5927\u5b78\u76ae\u819a\u75c5\u5b78\u7814\u7a76\u6240\u5e38\u52d9\u526f\u6240\u9577\uff0c\u4e2d\u570b\u91ab\u5e2b\u5354\u6703\u76ae\u819a\u79d1\u91ab\u5e2b\u5206\u6703\u526f\u6703\u9577\uff0cASC40\u4e2d\u3001\u91cd\u5ea6\u75e4\u7621III\u671f\u81e8\u5e8a\u8a66\u9a57\u4e3b\u8981\u7814\u7a76\u8005\u9805\u857e\u7d05\u6559\u6388\u8868\u793a\u3002 \u300c\u5f88\u9ad8\u8208\u6b4c\u79ae\u53d6\u5f97\u4e86\u53c8\u4e00\u500b\u88e1\u7a0b\u7891\uff0c\u5f70\u986f\u4e86\u6211\u5011\u628a\u7ba1\u7dda\u9805\u76ee\u5feb\u901f\u63a8\u9032\u5230\u81e8\u5e8a\u5f8c\u671f\u7684\u5353\u8d8a\u57f7\u884c\u529b\u3002\u4f5c\u70ba\u540c\u985e\u9996\u5275\u3001\u64c1\u6709\u6cbb\u7642\u75e4\u7621\u65b0\u578b\u4f5c\u7528\u6a5f\u5236\u7684\u5019\u9078\u85e5\u7269\uff0cASC40\u5728II\u671f\u7814\u7a76\u4e2d\u8868\u73fe\u51fa\u4e86\u986f\u8457\u7684\u7642\u6548\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u3002\u6211\u5011\u76f8\u4fe1\uff0c\u5168\u65b0\u7684\u4f5c\u7528\u6a5f\u5236\u5c07\u6709\u52a9\u65bcASC40\u6210\u70ba\u6cbb\u7642\u4e2d\u3001\u91cd\u5ea6\u75e4\u7621\u5b89\u5168\u4e14\u6709\u6548\u7684\u65b9\u6848\u3002\u300d\u6b4c\u79ae\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u6703\u4e3b\u5e2d\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u5433\u52c1\u6893\u535a\u58eb\u8868\u793a\u3002 [1]Tan J K, Bhate K. A global perspective on the epidemiology of acne [J]. Br J Dermatol 2015, 172 Suppl 1(3-12). DOI: 10.1111\/bjd.13462. [2]Purvis CG, Balogh EA, Feldman SR. Clascoterone: How the Novel Androgen Receptor Inhibitor Fits Into the Acne Treatment Paradigm. Ann Pharmacother. 2021;55(10):1297-1299. doi:10.1177\/1060028021992055. \u95dc\u65bc\u6b4c\u79ae \u6b4c\u79ae\u662f\u4e00\u5bb6\u5728\u9999\u6e2f\u8b49\u5238\u4ea4\u6613\u6240\u4e0a\u5e02\uff081672.HK\uff09\u7684\u5275\u65b0\u7814\u767c\u9a45\u52d5\u578b\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u6db5\u84cb\u4e86\u5f9e\u65b0\u85e5\u7814\u767c\u81f3\u751f\u7522\u548c\u5546\u696d\u5316\u7684\u5b8c\u6574\u50f9\u503c\u93c8\u3002\u6b4c\u79ae\u7684\u7ba1\u7406\u5718\u968a\u5177\u5099\u6df1\u539a\u7684\u5c08\u696d\u77e5\u8b58\u53ca\u512a\u79c0\u7684\u904e\u5f80\u6210\u5c31\uff0c\u5728\u5718\u968a\u7684\u5e36\u9818\u4e0b\uff0c\u6b4c\u79ae\u805a\u7126\u4e09\u5927\u81e8\u5e8a\u9700\u6c42\u5c1a\u672a\u6eff\u8db3\u7684\u91ab\u7642\u9818\u57df\uff1a\u75c5\u6bd2\u6027\u75be\u75c5\u3001\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\u548c\u816b\u7624\uff0c\u4e26\u4ee5\u5168\u7403\u5316\u7684\u8996\u91ce\u9032\u884c\u5e03\u5c40\u3002\u6191\u501f\u5353\u8d8a\u7684\u57f7\u884c\u529b\uff0c\u6b4c\u79ae\u5feb\u901f\u63a8\u9032\u85e5\u7269\u7ba1\u7dda\u958b\u767c\uff0c\u722d\u53d6\u5728\u570b\u969b\u7af6\u722d\u4e2d\u5360\u64da\u9818\u5148\u5730\u4f4d\u3002\u6b4c\u79ae\u76ee\u524d\u64c1\u6709\u591a\u6b3e\u5728\u7814\u85e5\u7269, \u6700\u524d\u6cbf\u7684\u5019\u9078\u85e5\u7269\u5305\u62ecASC22\uff08\u4e59\u809d\u529f\u80fd\u6027\u6cbb\u6108\uff09\u3001ASC40\uff08\u75e4\u7621\uff09\u3001ASC40\uff08\u5fa9\u767c\u6027\u81a0\u8cea\u6bcd\u7d30\u80de\u7624\uff09\u3001ASC40(\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e)\u3001ASC41(\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e)\u53caASC61\uff08\u665a\u671f\u5be6\u9ad4\u7624\uff09\u3002 \u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8acb\u767b\u9304\u7db2\u7ad9\uff1awww.ascletis.com\u3002<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_generate-full-width-content":"","spay_email":"","footnotes":""},"categories":[1],"tags":[],"yoast_head":"\n\u6b4c\u79ae\u5ba3\u5e03\u555f\u52d5ASC40\uff08\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff09\u6cbb\u7642\u75e4\u7621\u2162\u671f\u81e8\u5e8a\u8a66\u9a57 - \u9999\u6e2f\u7279\u8a31\u7d93\u71df<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.franchise.com.hk\/en\/%e6%ad%8c%e7%a6%ae%e5%ae%a3%e5%b8%83%e5%95%9f%e5%8b%95asc40%ef%bc%88%e5%9c%b0%e5%b0%bc%e6%b3%95%e5%8f%b8%e4%bb%96%ef%bc%89%e6%b2%bb%e7%99%82%e7%97%a4%e7%98%a1%e2%85%a2%e6%9c%9f%e8%87%a8%e5%ba%8a\/16364\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u6b4c\u79ae\u5ba3\u5e03\u555f\u52d5ASC40\uff08\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff09\u6cbb\u7642\u75e4\u7621\u2162\u671f\u81e8\u5e8a\u8a66\u9a57 - \u9999\u6e2f\u7279\u8a31\u7d93\u71df\" \/>\n<meta property=\"og:description\" content=\"–ASC40\u6cbb\u7642\u4e2d\u3001\u91cd\u5ea6\u5c0b\u5e38\u6027\u75e4\u7621\u7684\u2162\u671f\u81e8\u5e8a\u8a66\u9a57\u5c07\u5165\u7d44480\u4f8b\u53d7\u8a66\u8005 –III\u671f\u81e8\u5e8a\u8a66\u9a57\u65b9\u6848\u5df2\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\u540c\u610f\uff0c\u4e26\u5df2\u7372\u5f97\u5fa9\u65e6\u5927\u5b78\u9644\u5c6c\u83ef\u5c71\u91ab\u9662\u6a5f\u69cb\u502b\u7406\u59d4\u54e1\u6703\u6279\u51c6\u00a0 –\u5fa9\u65e6\u5927\u5b78\u9644\u5c6c\u83ef\u5c71\u91ab\u9662\u9805\u857e\u7d05\u6559\u6388\u64d4\u4efb\u9019\u9805III\u671f\u81e8\u5e8a\u8a66\u9a57\u7684\u4e3b\u8981\u7814\u7a76\u8005 \u676d\u5dde\u548c\u7d39\u82082023\u5e7412\u67085\u65e5 \/\u7f8e\u901a\u793e\/ — \u6b4c\u79ae\u5236\u85e5\u6709\u9650\u516c\u53f8\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a1672\uff0c\u300c\u6b4c\u79ae\u300d\uff09\u4eca\u65e5\u5ba3\u5e03\u555f\u52d5\u8102\u80aa\u9178\u5408\u6210\u9176\uff08FASN\uff09\u6291\u5236\u5291ASC40\uff08\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff09\u6cbb\u7642\u4e2d\u3001\u91cd\u5ea6\u5c0b\u5e38\u6027\u75e4\u7621\u7684III\u671f\u81e8\u5e8a\u8a66\u9a57\u3002\u00a0 \u9019\u9805III\u671f\u81e8\u5e8a\u8a66\u9a57\u662f\u4e00\u9805\u5728\u4e2d\u570b\u958b\u5c55\u7684\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u3001\u591a\u4e2d\u5fc3\u7684\u81e8\u5e8a\u8a66\u9a57\uff0c\u65e8\u5728\u8a55\u4f30ASC40\u6cbb\u7642\u4e2d\u3001\u91cd\u5ea6\u5c0b\u5e38\u6027\u75e4\u7621\u7684\u5b89\u5168\u6027\u548c\u7642\u6548\u3002480\u4f8b\u4e2d\u3001\u91cd\u5ea6\u5c0b\u5e38\u6027\u75e4\u7621\u53d7\u8a66\u8005\u5c07\u88ab\u6309\u71671:1\u7684\u6bd4\u4f8b\u96a8\u6a5f\u5206\u81f3\u4e00\u500b\u6d3b\u6027\u85e5\u7269\u7d44\u548c\u4e00\u500b\u5b89\u6170\u5291\u5c0d\u7167\u7d44\uff0c\u63a5\u53d7\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d50\u6beb\u514bASC40\u6216\u5339\u914d\u7684\u5b89\u6170\u5291\u6cbb\u7642\uff0c\u70ba\u671f12\u5468\u3002 \u4e3b\u8981\u7642\u6548\u7d42\u9ede\u70ba\uff1a\u7b2c12\u5468\u6642\uff0c\u6cbb\u7642\u6210\u529f\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\uff0c\u53d7\u8a66\u8005\u7e3d\u76ae\u640d\u8a08\u6578\u76f8\u5c0d\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316\uff0c\u4ee5\u53ca\u53d7\u8a66\u8005\u708e\u6027\u76ae\u640d\u8a08\u6578\u76f8\u5c0d\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316\u3002\u6cbb\u7642\u6210\u529f\u7684\u5b9a\u7fa9\u70ba\uff1a\u7814\u7a76\u8005\u7e3d\u9ad4\u8a55\u4f30\uff08IGA\uff09\u8a55\u5206\u8f03\u57fa\u7dda\u4e0b\u964d\u22652\u5206\uff0c\u4e14IGA\u5206\u7d1a\u70ba\u5149\u6f54\uff080\u5206\uff09\u6216\u5e7e\u4e4e\u5149\u6f54\uff081\u5206\uff09\u3002 III\u671f\u81e8\u5e8a\u8a66\u9a57\u65b9\u6848\u5df2\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\u540c\u610f\uff0c\u4e26\u5df2\u7372\u5f97\u5fa9\u65e6\u5927\u5b78\u9644\u5c6c\u83ef\u5c71\u91ab\u9662\u6a5f\u69cb\u502b\u7406\u59d4\u54e1\u6703\u6279\u51c6\u3002 2023\u5e745\u67082\u65e5\uff0c\u6b4c\u79ae\u5ba3\u5e03ASC40\u6cbb\u7642\u5c0b\u5e38\u6027\u75e4\u7621\u7684II\u671f\u81e8\u5e8a\u8a66\u9a57\u9054\u5230\u4e3b\u8981\u53ca\u95dc\u9375\u6b21\u8981\u7d42\u9ede\uff0c\u8868\u73fe\u51fa\u4e86\u986f\u8457\u7684\u7642\u6548\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u3002 ASC40\u662f\u4e00\u7a2e\u53e3\u670d\u3001\u9078\u64c7\u6027\u5c0f\u5206\u5b50FASN\u6291\u5236\u5291\u3002ASC40\u6cbb\u7642\u75e4\u7621\u7684\u6a5f\u5236\u662f\uff1a\uff081\uff09\u901a\u904e\u6291\u5236\u4eba\u76ae\u8102\u7d30\u80de\u7684\u8102\u80aa\u9178\u5f9e\u982d\u5408\u6210\uff08DNL\uff09\uff0c\u76f4\u63a5\u6291\u5236\u9762\u90e8\u76ae\u8102\u751f\u6210\uff1b\u548c\uff082\uff09\u901a\u904e\u6e1b\u5c11\u7d30\u80de\u56e0\u5b50\u5206\u6ccc\u548cTh17\u5206\u5316\u4f86\u6291\u5236\u708e\u75c7\u3002\u6b4c\u79ae\u5df2\u5f9eSagimet Biosciences Inc.\u7372\u5f97ASC40\u5728\u5927\u4e2d\u83ef\u5340\u7684\u958b\u767c\u3001\u751f\u7522\u548c\u5546\u696d\u5316\u7368\u5bb6\u6b0a\u76ca\u3002 \u75e4\u7621\u662f\u5168\u7403\u7b2c\u516b\u5927\u5e38\u898b\u75be\u75c5\uff0c\u5f71\u97ff\u5168\u7403\u8d85\u904e6.4\u5104\u4eba[1]\u3002\u8207\u53e3\u670d\u85e5\u7269\u76f8\u6bd4\uff0c\u5916\u7528\u7642\u6cd5\u7684\u4f9d\u5f9e\u6027\u66f4\u4f4e\uff1a\u64da\u4f30\u8a08\uff0c\u7d04\u670930%\u81f340%\u7684\u60a3\u8005\u7121\u6cd5\u5805\u6301\u5916\u7528\u6cbb\u7642[2]\u3002\u76ee\u524d\uff0c\u6709\u6548\u7684\u53e3\u670d\u75e4\u7621\u85e5\u7269\u4e3b\u8981\u662f\u7570\u7dadA\u9178\uff0c\u5176\u53ef\u80fd\u6703\u5c0e\u81f4\u8a31\u591a\u56b4\u91cd\u7684\u4e0d\u826f\u4e8b\u4ef6\uff0c\u5982\u809d\u6bd2\u6027\u3001\u807d\u529b\u969c\u7919\u548c\u6291\u90c1\u75c7\u7b49\u3002ASC40\u6709\u671b\u6210\u70ba\u540c\u985e\u9996\u5275\u3001\u6bcf\u65e5\u4e00\u6b21\u3001\u60a3\u8005\u4f9d\u5f9e\u6027\u9ad8\u7684\u53e3\u670d\u75e4\u7621\u85e5\u7269\u3002 \u300c\u75e4\u7621\u6cbb\u7642\u7f3a\u4e4f\u65b0\u85e5\u4e0a\u5e02\uff0cASC40\u662f\u5177\u6709\u5168\u65b0\u4f5c\u7528\u6a5f\u5236\u7684\u53e3\u670d\u75e4\u7621\u5019\u9078\u85e5\u7269\u3002\u300d\u5fa9\u65e6\u5927\u5b78\u9644\u5c6c\u83ef\u5c71\u91ab\u9662\u76ae\u819a\u79d1\u4e3b\u4efb\u91ab\u5e2b\uff0c\u5fa9\u65e6\u5927\u5b78\u76ae\u819a\u75c5\u5b78\u7814\u7a76\u6240\u5e38\u52d9\u526f\u6240\u9577\uff0c\u4e2d\u570b\u91ab\u5e2b\u5354\u6703\u76ae\u819a\u79d1\u91ab\u5e2b\u5206\u6703\u526f\u6703\u9577\uff0cASC40\u4e2d\u3001\u91cd\u5ea6\u75e4\u7621III\u671f\u81e8\u5e8a\u8a66\u9a57\u4e3b\u8981\u7814\u7a76\u8005\u9805\u857e\u7d05\u6559\u6388\u8868\u793a\u3002 \u300c\u5f88\u9ad8\u8208\u6b4c\u79ae\u53d6\u5f97\u4e86\u53c8\u4e00\u500b\u88e1\u7a0b\u7891\uff0c\u5f70\u986f\u4e86\u6211\u5011\u628a\u7ba1\u7dda\u9805\u76ee\u5feb\u901f\u63a8\u9032\u5230\u81e8\u5e8a\u5f8c\u671f\u7684\u5353\u8d8a\u57f7\u884c\u529b\u3002\u4f5c\u70ba\u540c\u985e\u9996\u5275\u3001\u64c1\u6709\u6cbb\u7642\u75e4\u7621\u65b0\u578b\u4f5c\u7528\u6a5f\u5236\u7684\u5019\u9078\u85e5\u7269\uff0cASC40\u5728II\u671f\u7814\u7a76\u4e2d\u8868\u73fe\u51fa\u4e86\u986f\u8457\u7684\u7642\u6548\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u3002\u6211\u5011\u76f8\u4fe1\uff0c\u5168\u65b0\u7684\u4f5c\u7528\u6a5f\u5236\u5c07\u6709\u52a9\u65bcASC40\u6210\u70ba\u6cbb\u7642\u4e2d\u3001\u91cd\u5ea6\u75e4\u7621\u5b89\u5168\u4e14\u6709\u6548\u7684\u65b9\u6848\u3002\u300d\u6b4c\u79ae\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u6703\u4e3b\u5e2d\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u5433\u52c1\u6893\u535a\u58eb\u8868\u793a\u3002 [1]Tan J K, Bhate K. A global perspective on the epidemiology of acne [J]. Br J Dermatol 2015, 172 Suppl 1(3-12). DOI: 10.1111\/bjd.13462. [2]Purvis CG, Balogh EA, Feldman SR. Clascoterone: How the Novel Androgen Receptor Inhibitor Fits Into the Acne Treatment Paradigm. Ann Pharmacother. 2021;55(10):1297-1299. doi:10.1177\/1060028021992055. \u95dc\u65bc\u6b4c\u79ae \u6b4c\u79ae\u662f\u4e00\u5bb6\u5728\u9999\u6e2f\u8b49\u5238\u4ea4\u6613\u6240\u4e0a\u5e02\uff081672.HK\uff09\u7684\u5275\u65b0\u7814\u767c\u9a45\u52d5\u578b\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u6db5\u84cb\u4e86\u5f9e\u65b0\u85e5\u7814\u767c\u81f3\u751f\u7522\u548c\u5546\u696d\u5316\u7684\u5b8c\u6574\u50f9\u503c\u93c8\u3002\u6b4c\u79ae\u7684\u7ba1\u7406\u5718\u968a\u5177\u5099\u6df1\u539a\u7684\u5c08\u696d\u77e5\u8b58\u53ca\u512a\u79c0\u7684\u904e\u5f80\u6210\u5c31\uff0c\u5728\u5718\u968a\u7684\u5e36\u9818\u4e0b\uff0c\u6b4c\u79ae\u805a\u7126\u4e09\u5927\u81e8\u5e8a\u9700\u6c42\u5c1a\u672a\u6eff\u8db3\u7684\u91ab\u7642\u9818\u57df\uff1a\u75c5\u6bd2\u6027\u75be\u75c5\u3001\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\u548c\u816b\u7624\uff0c\u4e26\u4ee5\u5168\u7403\u5316\u7684\u8996\u91ce\u9032\u884c\u5e03\u5c40\u3002\u6191\u501f\u5353\u8d8a\u7684\u57f7\u884c\u529b\uff0c\u6b4c\u79ae\u5feb\u901f\u63a8\u9032\u85e5\u7269\u7ba1\u7dda\u958b\u767c\uff0c\u722d\u53d6\u5728\u570b\u969b\u7af6\u722d\u4e2d\u5360\u64da\u9818\u5148\u5730\u4f4d\u3002\u6b4c\u79ae\u76ee\u524d\u64c1\u6709\u591a\u6b3e\u5728\u7814\u85e5\u7269, \u6700\u524d\u6cbf\u7684\u5019\u9078\u85e5\u7269\u5305\u62ecASC22\uff08\u4e59\u809d\u529f\u80fd\u6027\u6cbb\u6108\uff09\u3001ASC40\uff08\u75e4\u7621\uff09\u3001ASC40\uff08\u5fa9\u767c\u6027\u81a0\u8cea\u6bcd\u7d30\u80de\u7624\uff09\u3001ASC40(\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e)\u3001ASC41(\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e)\u53caASC61\uff08\u665a\u671f\u5be6\u9ad4\u7624\uff09\u3002 \u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8acb\u767b\u9304\u7db2\u7ad9\uff1awww.ascletis.com\u3002\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.franchise.com.hk\/en\/%e6%ad%8c%e7%a6%ae%e5%ae%a3%e5%b8%83%e5%95%9f%e5%8b%95asc40%ef%bc%88%e5%9c%b0%e5%b0%bc%e6%b3%95%e5%8f%b8%e4%bb%96%ef%bc%89%e6%b2%bb%e7%99%82%e7%97%a4%e7%98%a1%e2%85%a2%e6%9c%9f%e8%87%a8%e5%ba%8a\/16364\" \/>\n<meta property=\"og:site_name\" content=\"\u9999\u6e2f\u7279\u8a31\u7d93\u71df\" \/>\n<meta property=\"article:published_time\" content=\"2023-12-05T00:50:00+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.franchise.com.hk\/en\/%e6%ad%8c%e7%a6%ae%e5%ae%a3%e5%b8%83%e5%95%9f%e5%8b%95asc40%ef%bc%88%e5%9c%b0%e5%b0%bc%e6%b3%95%e5%8f%b8%e4%bb%96%ef%bc%89%e6%b2%bb%e7%99%82%e7%97%a4%e7%98%a1%e2%85%a2%e6%9c%9f%e8%87%a8%e5%ba%8a\/16364#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.franchise.com.hk\/en\/%e6%ad%8c%e7%a6%ae%e5%ae%a3%e5%b8%83%e5%95%9f%e5%8b%95asc40%ef%bc%88%e5%9c%b0%e5%b0%bc%e6%b3%95%e5%8f%b8%e4%bb%96%ef%bc%89%e6%b2%bb%e7%99%82%e7%97%a4%e7%98%a1%e2%85%a2%e6%9c%9f%e8%87%a8%e5%ba%8a\/16364\"},\"author\":{\"name\":\"\",\"@id\":\"\"},\"headline\":\"\u6b4c\u79ae\u5ba3\u5e03\u555f\u52d5ASC40\uff08\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff09\u6cbb\u7642\u75e4\u7621\u2162\u671f\u81e8\u5e8a\u8a66\u9a57\",\"datePublished\":\"2023-12-05T00:50:00+00:00\",\"dateModified\":\"2023-12-05T00:50:00+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.franchise.com.hk\/en\/%e6%ad%8c%e7%a6%ae%e5%ae%a3%e5%b8%83%e5%95%9f%e5%8b%95asc40%ef%bc%88%e5%9c%b0%e5%b0%bc%e6%b3%95%e5%8f%b8%e4%bb%96%ef%bc%89%e6%b2%bb%e7%99%82%e7%97%a4%e7%98%a1%e2%85%a2%e6%9c%9f%e8%87%a8%e5%ba%8a\/16364\"},\"wordCount\":88,\"publisher\":{\"@id\":\"https:\/\/www.franchise.com.hk\/en#organization\"},\"articleSection\":[\"\u672a\u5206\u985e\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.franchise.com.hk\/en\/%e6%ad%8c%e7%a6%ae%e5%ae%a3%e5%b8%83%e5%95%9f%e5%8b%95asc40%ef%bc%88%e5%9c%b0%e5%b0%bc%e6%b3%95%e5%8f%b8%e4%bb%96%ef%bc%89%e6%b2%bb%e7%99%82%e7%97%a4%e7%98%a1%e2%85%a2%e6%9c%9f%e8%87%a8%e5%ba%8a\/16364\",\"url\":\"https:\/\/www.franchise.com.hk\/en\/%e6%ad%8c%e7%a6%ae%e5%ae%a3%e5%b8%83%e5%95%9f%e5%8b%95asc40%ef%bc%88%e5%9c%b0%e5%b0%bc%e6%b3%95%e5%8f%b8%e4%bb%96%ef%bc%89%e6%b2%bb%e7%99%82%e7%97%a4%e7%98%a1%e2%85%a2%e6%9c%9f%e8%87%a8%e5%ba%8a\/16364\",\"name\":\"\u6b4c\u79ae\u5ba3\u5e03\u555f\u52d5ASC40\uff08\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff09\u6cbb\u7642\u75e4\u7621\u2162\u671f\u81e8\u5e8a\u8a66\u9a57 - \u9999\u6e2f\u7279\u8a31\u7d93\u71df\",\"isPartOf\":{\"@id\":\"https:\/\/www.franchise.com.hk\/en#website\"},\"datePublished\":\"2023-12-05T00:50:00+00:00\",\"dateModified\":\"2023-12-05T00:50:00+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.franchise.com.hk\/en\/%e6%ad%8c%e7%a6%ae%e5%ae%a3%e5%b8%83%e5%95%9f%e5%8b%95asc40%ef%bc%88%e5%9c%b0%e5%b0%bc%e6%b3%95%e5%8f%b8%e4%bb%96%ef%bc%89%e6%b2%bb%e7%99%82%e7%97%a4%e7%98%a1%e2%85%a2%e6%9c%9f%e8%87%a8%e5%ba%8a\/16364#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.franchise.com.hk\/en\/%e6%ad%8c%e7%a6%ae%e5%ae%a3%e5%b8%83%e5%95%9f%e5%8b%95asc40%ef%bc%88%e5%9c%b0%e5%b0%bc%e6%b3%95%e5%8f%b8%e4%bb%96%ef%bc%89%e6%b2%bb%e7%99%82%e7%97%a4%e7%98%a1%e2%85%a2%e6%9c%9f%e8%87%a8%e5%ba%8a\/16364\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.franchise.com.hk\/en\/%e6%ad%8c%e7%a6%ae%e5%ae%a3%e5%b8%83%e5%95%9f%e5%8b%95asc40%ef%bc%88%e5%9c%b0%e5%b0%bc%e6%b3%95%e5%8f%b8%e4%bb%96%ef%bc%89%e6%b2%bb%e7%99%82%e7%97%a4%e7%98%a1%e2%85%a2%e6%9c%9f%e8%87%a8%e5%ba%8a\/16364#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9801\",\"item\":\"https:\/\/www.franchise.com.hk\/en\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u6b4c\u79ae\u5ba3\u5e03\u555f\u52d5ASC40\uff08\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff09\u6cbb\u7642\u75e4\u7621\u2162\u671f\u81e8\u5e8a\u8a66\u9a57\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.franchise.com.hk\/en#website\",\"url\":\"https:\/\/www.franchise.com.hk\/en\",\"name\":\"\u9999\u6e2f\u7279\u8a31\u7d93\u71df\",\"description\":\"\u9999\u6e2f\u7279\u8a31\u7d93\u71df | Franchise HK\",\"publisher\":{\"@id\":\"https:\/\/www.franchise.com.hk\/en#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.franchise.com.hk\/en?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.franchise.com.hk\/en#organization\",\"name\":\"\u9999\u6e2f\u7279\u8a31\u7d93\u71df\",\"url\":\"https:\/\/www.franchise.com.hk\/en\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.franchise.com.hk\/en#\/schema\/logo\/image\/\",\"url\":\"https:\/\/i0.wp.com\/www.franchise.com.hk\/wp-content\/uploads\/2022\/05\/cropped-cropped-franchise-logo-02-e1652686851566-2.png?fit=350%2C76&ssl=1\",\"contentUrl\":\"https:\/\/i0.wp.com\/www.franchise.com.hk\/wp-content\/uploads\/2022\/05\/cropped-cropped-franchise-logo-02-e1652686851566-2.png?fit=350%2C76&ssl=1\",\"width\":350,\"height\":76,\"caption\":\"\u9999\u6e2f\u7279\u8a31\u7d93\u71df\"},\"image\":{\"@id\":\"https:\/\/www.franchise.com.hk\/en#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u6b4c\u79ae\u5ba3\u5e03\u555f\u52d5ASC40\uff08\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff09\u6cbb\u7642\u75e4\u7621\u2162\u671f\u81e8\u5e8a\u8a66\u9a57 - \u9999\u6e2f\u7279\u8a31\u7d93\u71df","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.franchise.com.hk\/en\/%e6%ad%8c%e7%a6%ae%e5%ae%a3%e5%b8%83%e5%95%9f%e5%8b%95asc40%ef%bc%88%e5%9c%b0%e5%b0%bc%e6%b3%95%e5%8f%b8%e4%bb%96%ef%bc%89%e6%b2%bb%e7%99%82%e7%97%a4%e7%98%a1%e2%85%a2%e6%9c%9f%e8%87%a8%e5%ba%8a\/16364","og_locale":"en_US","og_type":"article","og_title":"\u6b4c\u79ae\u5ba3\u5e03\u555f\u52d5ASC40\uff08\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff09\u6cbb\u7642\u75e4\u7621\u2162\u671f\u81e8\u5e8a\u8a66\u9a57 - \u9999\u6e2f\u7279\u8a31\u7d93\u71df","og_description":"–ASC40\u6cbb\u7642\u4e2d\u3001\u91cd\u5ea6\u5c0b\u5e38\u6027\u75e4\u7621\u7684\u2162\u671f\u81e8\u5e8a\u8a66\u9a57\u5c07\u5165\u7d44480\u4f8b\u53d7\u8a66\u8005 –III\u671f\u81e8\u5e8a\u8a66\u9a57\u65b9\u6848\u5df2\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\u540c\u610f\uff0c\u4e26\u5df2\u7372\u5f97\u5fa9\u65e6\u5927\u5b78\u9644\u5c6c\u83ef\u5c71\u91ab\u9662\u6a5f\u69cb\u502b\u7406\u59d4\u54e1\u6703\u6279\u51c6\u00a0 –\u5fa9\u65e6\u5927\u5b78\u9644\u5c6c\u83ef\u5c71\u91ab\u9662\u9805\u857e\u7d05\u6559\u6388\u64d4\u4efb\u9019\u9805III\u671f\u81e8\u5e8a\u8a66\u9a57\u7684\u4e3b\u8981\u7814\u7a76\u8005 \u676d\u5dde\u548c\u7d39\u82082023\u5e7412\u67085\u65e5 \/\u7f8e\u901a\u793e\/ — \u6b4c\u79ae\u5236\u85e5\u6709\u9650\u516c\u53f8\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a1672\uff0c\u300c\u6b4c\u79ae\u300d\uff09\u4eca\u65e5\u5ba3\u5e03\u555f\u52d5\u8102\u80aa\u9178\u5408\u6210\u9176\uff08FASN\uff09\u6291\u5236\u5291ASC40\uff08\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff09\u6cbb\u7642\u4e2d\u3001\u91cd\u5ea6\u5c0b\u5e38\u6027\u75e4\u7621\u7684III\u671f\u81e8\u5e8a\u8a66\u9a57\u3002\u00a0 \u9019\u9805III\u671f\u81e8\u5e8a\u8a66\u9a57\u662f\u4e00\u9805\u5728\u4e2d\u570b\u958b\u5c55\u7684\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u3001\u591a\u4e2d\u5fc3\u7684\u81e8\u5e8a\u8a66\u9a57\uff0c\u65e8\u5728\u8a55\u4f30ASC40\u6cbb\u7642\u4e2d\u3001\u91cd\u5ea6\u5c0b\u5e38\u6027\u75e4\u7621\u7684\u5b89\u5168\u6027\u548c\u7642\u6548\u3002480\u4f8b\u4e2d\u3001\u91cd\u5ea6\u5c0b\u5e38\u6027\u75e4\u7621\u53d7\u8a66\u8005\u5c07\u88ab\u6309\u71671:1\u7684\u6bd4\u4f8b\u96a8\u6a5f\u5206\u81f3\u4e00\u500b\u6d3b\u6027\u85e5\u7269\u7d44\u548c\u4e00\u500b\u5b89\u6170\u5291\u5c0d\u7167\u7d44\uff0c\u63a5\u53d7\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d50\u6beb\u514bASC40\u6216\u5339\u914d\u7684\u5b89\u6170\u5291\u6cbb\u7642\uff0c\u70ba\u671f12\u5468\u3002 \u4e3b\u8981\u7642\u6548\u7d42\u9ede\u70ba\uff1a\u7b2c12\u5468\u6642\uff0c\u6cbb\u7642\u6210\u529f\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\uff0c\u53d7\u8a66\u8005\u7e3d\u76ae\u640d\u8a08\u6578\u76f8\u5c0d\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316\uff0c\u4ee5\u53ca\u53d7\u8a66\u8005\u708e\u6027\u76ae\u640d\u8a08\u6578\u76f8\u5c0d\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316\u3002\u6cbb\u7642\u6210\u529f\u7684\u5b9a\u7fa9\u70ba\uff1a\u7814\u7a76\u8005\u7e3d\u9ad4\u8a55\u4f30\uff08IGA\uff09\u8a55\u5206\u8f03\u57fa\u7dda\u4e0b\u964d\u22652\u5206\uff0c\u4e14IGA\u5206\u7d1a\u70ba\u5149\u6f54\uff080\u5206\uff09\u6216\u5e7e\u4e4e\u5149\u6f54\uff081\u5206\uff09\u3002 III\u671f\u81e8\u5e8a\u8a66\u9a57\u65b9\u6848\u5df2\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\u540c\u610f\uff0c\u4e26\u5df2\u7372\u5f97\u5fa9\u65e6\u5927\u5b78\u9644\u5c6c\u83ef\u5c71\u91ab\u9662\u6a5f\u69cb\u502b\u7406\u59d4\u54e1\u6703\u6279\u51c6\u3002 2023\u5e745\u67082\u65e5\uff0c\u6b4c\u79ae\u5ba3\u5e03ASC40\u6cbb\u7642\u5c0b\u5e38\u6027\u75e4\u7621\u7684II\u671f\u81e8\u5e8a\u8a66\u9a57\u9054\u5230\u4e3b\u8981\u53ca\u95dc\u9375\u6b21\u8981\u7d42\u9ede\uff0c\u8868\u73fe\u51fa\u4e86\u986f\u8457\u7684\u7642\u6548\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u3002 ASC40\u662f\u4e00\u7a2e\u53e3\u670d\u3001\u9078\u64c7\u6027\u5c0f\u5206\u5b50FASN\u6291\u5236\u5291\u3002ASC40\u6cbb\u7642\u75e4\u7621\u7684\u6a5f\u5236\u662f\uff1a\uff081\uff09\u901a\u904e\u6291\u5236\u4eba\u76ae\u8102\u7d30\u80de\u7684\u8102\u80aa\u9178\u5f9e\u982d\u5408\u6210\uff08DNL\uff09\uff0c\u76f4\u63a5\u6291\u5236\u9762\u90e8\u76ae\u8102\u751f\u6210\uff1b\u548c\uff082\uff09\u901a\u904e\u6e1b\u5c11\u7d30\u80de\u56e0\u5b50\u5206\u6ccc\u548cTh17\u5206\u5316\u4f86\u6291\u5236\u708e\u75c7\u3002\u6b4c\u79ae\u5df2\u5f9eSagimet Biosciences Inc.\u7372\u5f97ASC40\u5728\u5927\u4e2d\u83ef\u5340\u7684\u958b\u767c\u3001\u751f\u7522\u548c\u5546\u696d\u5316\u7368\u5bb6\u6b0a\u76ca\u3002 \u75e4\u7621\u662f\u5168\u7403\u7b2c\u516b\u5927\u5e38\u898b\u75be\u75c5\uff0c\u5f71\u97ff\u5168\u7403\u8d85\u904e6.4\u5104\u4eba[1]\u3002\u8207\u53e3\u670d\u85e5\u7269\u76f8\u6bd4\uff0c\u5916\u7528\u7642\u6cd5\u7684\u4f9d\u5f9e\u6027\u66f4\u4f4e\uff1a\u64da\u4f30\u8a08\uff0c\u7d04\u670930%\u81f340%\u7684\u60a3\u8005\u7121\u6cd5\u5805\u6301\u5916\u7528\u6cbb\u7642[2]\u3002\u76ee\u524d\uff0c\u6709\u6548\u7684\u53e3\u670d\u75e4\u7621\u85e5\u7269\u4e3b\u8981\u662f\u7570\u7dadA\u9178\uff0c\u5176\u53ef\u80fd\u6703\u5c0e\u81f4\u8a31\u591a\u56b4\u91cd\u7684\u4e0d\u826f\u4e8b\u4ef6\uff0c\u5982\u809d\u6bd2\u6027\u3001\u807d\u529b\u969c\u7919\u548c\u6291\u90c1\u75c7\u7b49\u3002ASC40\u6709\u671b\u6210\u70ba\u540c\u985e\u9996\u5275\u3001\u6bcf\u65e5\u4e00\u6b21\u3001\u60a3\u8005\u4f9d\u5f9e\u6027\u9ad8\u7684\u53e3\u670d\u75e4\u7621\u85e5\u7269\u3002 \u300c\u75e4\u7621\u6cbb\u7642\u7f3a\u4e4f\u65b0\u85e5\u4e0a\u5e02\uff0cASC40\u662f\u5177\u6709\u5168\u65b0\u4f5c\u7528\u6a5f\u5236\u7684\u53e3\u670d\u75e4\u7621\u5019\u9078\u85e5\u7269\u3002\u300d\u5fa9\u65e6\u5927\u5b78\u9644\u5c6c\u83ef\u5c71\u91ab\u9662\u76ae\u819a\u79d1\u4e3b\u4efb\u91ab\u5e2b\uff0c\u5fa9\u65e6\u5927\u5b78\u76ae\u819a\u75c5\u5b78\u7814\u7a76\u6240\u5e38\u52d9\u526f\u6240\u9577\uff0c\u4e2d\u570b\u91ab\u5e2b\u5354\u6703\u76ae\u819a\u79d1\u91ab\u5e2b\u5206\u6703\u526f\u6703\u9577\uff0cASC40\u4e2d\u3001\u91cd\u5ea6\u75e4\u7621III\u671f\u81e8\u5e8a\u8a66\u9a57\u4e3b\u8981\u7814\u7a76\u8005\u9805\u857e\u7d05\u6559\u6388\u8868\u793a\u3002 \u300c\u5f88\u9ad8\u8208\u6b4c\u79ae\u53d6\u5f97\u4e86\u53c8\u4e00\u500b\u88e1\u7a0b\u7891\uff0c\u5f70\u986f\u4e86\u6211\u5011\u628a\u7ba1\u7dda\u9805\u76ee\u5feb\u901f\u63a8\u9032\u5230\u81e8\u5e8a\u5f8c\u671f\u7684\u5353\u8d8a\u57f7\u884c\u529b\u3002\u4f5c\u70ba\u540c\u985e\u9996\u5275\u3001\u64c1\u6709\u6cbb\u7642\u75e4\u7621\u65b0\u578b\u4f5c\u7528\u6a5f\u5236\u7684\u5019\u9078\u85e5\u7269\uff0cASC40\u5728II\u671f\u7814\u7a76\u4e2d\u8868\u73fe\u51fa\u4e86\u986f\u8457\u7684\u7642\u6548\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u3002\u6211\u5011\u76f8\u4fe1\uff0c\u5168\u65b0\u7684\u4f5c\u7528\u6a5f\u5236\u5c07\u6709\u52a9\u65bcASC40\u6210\u70ba\u6cbb\u7642\u4e2d\u3001\u91cd\u5ea6\u75e4\u7621\u5b89\u5168\u4e14\u6709\u6548\u7684\u65b9\u6848\u3002\u300d\u6b4c\u79ae\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u6703\u4e3b\u5e2d\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u5433\u52c1\u6893\u535a\u58eb\u8868\u793a\u3002 [1]Tan J K, Bhate K. A global perspective on the epidemiology of acne [J]. Br J Dermatol 2015, 172 Suppl 1(3-12). DOI: 10.1111\/bjd.13462. [2]Purvis CG, Balogh EA, Feldman SR. Clascoterone: How the Novel Androgen Receptor Inhibitor Fits Into the Acne Treatment Paradigm. Ann Pharmacother. 2021;55(10):1297-1299. doi:10.1177\/1060028021992055. \u95dc\u65bc\u6b4c\u79ae \u6b4c\u79ae\u662f\u4e00\u5bb6\u5728\u9999\u6e2f\u8b49\u5238\u4ea4\u6613\u6240\u4e0a\u5e02\uff081672.HK\uff09\u7684\u5275\u65b0\u7814\u767c\u9a45\u52d5\u578b\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u6db5\u84cb\u4e86\u5f9e\u65b0\u85e5\u7814\u767c\u81f3\u751f\u7522\u548c\u5546\u696d\u5316\u7684\u5b8c\u6574\u50f9\u503c\u93c8\u3002\u6b4c\u79ae\u7684\u7ba1\u7406\u5718\u968a\u5177\u5099\u6df1\u539a\u7684\u5c08\u696d\u77e5\u8b58\u53ca\u512a\u79c0\u7684\u904e\u5f80\u6210\u5c31\uff0c\u5728\u5718\u968a\u7684\u5e36\u9818\u4e0b\uff0c\u6b4c\u79ae\u805a\u7126\u4e09\u5927\u81e8\u5e8a\u9700\u6c42\u5c1a\u672a\u6eff\u8db3\u7684\u91ab\u7642\u9818\u57df\uff1a\u75c5\u6bd2\u6027\u75be\u75c5\u3001\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\u548c\u816b\u7624\uff0c\u4e26\u4ee5\u5168\u7403\u5316\u7684\u8996\u91ce\u9032\u884c\u5e03\u5c40\u3002\u6191\u501f\u5353\u8d8a\u7684\u57f7\u884c\u529b\uff0c\u6b4c\u79ae\u5feb\u901f\u63a8\u9032\u85e5\u7269\u7ba1\u7dda\u958b\u767c\uff0c\u722d\u53d6\u5728\u570b\u969b\u7af6\u722d\u4e2d\u5360\u64da\u9818\u5148\u5730\u4f4d\u3002\u6b4c\u79ae\u76ee\u524d\u64c1\u6709\u591a\u6b3e\u5728\u7814\u85e5\u7269, \u6700\u524d\u6cbf\u7684\u5019\u9078\u85e5\u7269\u5305\u62ecASC22\uff08\u4e59\u809d\u529f\u80fd\u6027\u6cbb\u6108\uff09\u3001ASC40\uff08\u75e4\u7621\uff09\u3001ASC40\uff08\u5fa9\u767c\u6027\u81a0\u8cea\u6bcd\u7d30\u80de\u7624\uff09\u3001ASC40(\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e)\u3001ASC41(\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e)\u53caASC61\uff08\u665a\u671f\u5be6\u9ad4\u7624\uff09\u3002 \u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8acb\u767b\u9304\u7db2\u7ad9\uff1awww.ascletis.com\u3002","og_url":"https:\/\/www.franchise.com.hk\/en\/%e6%ad%8c%e7%a6%ae%e5%ae%a3%e5%b8%83%e5%95%9f%e5%8b%95asc40%ef%bc%88%e5%9c%b0%e5%b0%bc%e6%b3%95%e5%8f%b8%e4%bb%96%ef%bc%89%e6%b2%bb%e7%99%82%e7%97%a4%e7%98%a1%e2%85%a2%e6%9c%9f%e8%87%a8%e5%ba%8a\/16364","og_site_name":"\u9999\u6e2f\u7279\u8a31\u7d93\u71df","article_published_time":"2023-12-05T00:50:00+00:00","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.franchise.com.hk\/en\/%e6%ad%8c%e7%a6%ae%e5%ae%a3%e5%b8%83%e5%95%9f%e5%8b%95asc40%ef%bc%88%e5%9c%b0%e5%b0%bc%e6%b3%95%e5%8f%b8%e4%bb%96%ef%bc%89%e6%b2%bb%e7%99%82%e7%97%a4%e7%98%a1%e2%85%a2%e6%9c%9f%e8%87%a8%e5%ba%8a\/16364#article","isPartOf":{"@id":"https:\/\/www.franchise.com.hk\/en\/%e6%ad%8c%e7%a6%ae%e5%ae%a3%e5%b8%83%e5%95%9f%e5%8b%95asc40%ef%bc%88%e5%9c%b0%e5%b0%bc%e6%b3%95%e5%8f%b8%e4%bb%96%ef%bc%89%e6%b2%bb%e7%99%82%e7%97%a4%e7%98%a1%e2%85%a2%e6%9c%9f%e8%87%a8%e5%ba%8a\/16364"},"author":{"name":"","@id":""},"headline":"\u6b4c\u79ae\u5ba3\u5e03\u555f\u52d5ASC40\uff08\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff09\u6cbb\u7642\u75e4\u7621\u2162\u671f\u81e8\u5e8a\u8a66\u9a57","datePublished":"2023-12-05T00:50:00+00:00","dateModified":"2023-12-05T00:50:00+00:00","mainEntityOfPage":{"@id":"https:\/\/www.franchise.com.hk\/en\/%e6%ad%8c%e7%a6%ae%e5%ae%a3%e5%b8%83%e5%95%9f%e5%8b%95asc40%ef%bc%88%e5%9c%b0%e5%b0%bc%e6%b3%95%e5%8f%b8%e4%bb%96%ef%bc%89%e6%b2%bb%e7%99%82%e7%97%a4%e7%98%a1%e2%85%a2%e6%9c%9f%e8%87%a8%e5%ba%8a\/16364"},"wordCount":88,"publisher":{"@id":"https:\/\/www.franchise.com.hk\/en#organization"},"articleSection":["\u672a\u5206\u985e"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.franchise.com.hk\/en\/%e6%ad%8c%e7%a6%ae%e5%ae%a3%e5%b8%83%e5%95%9f%e5%8b%95asc40%ef%bc%88%e5%9c%b0%e5%b0%bc%e6%b3%95%e5%8f%b8%e4%bb%96%ef%bc%89%e6%b2%bb%e7%99%82%e7%97%a4%e7%98%a1%e2%85%a2%e6%9c%9f%e8%87%a8%e5%ba%8a\/16364","url":"https:\/\/www.franchise.com.hk\/en\/%e6%ad%8c%e7%a6%ae%e5%ae%a3%e5%b8%83%e5%95%9f%e5%8b%95asc40%ef%bc%88%e5%9c%b0%e5%b0%bc%e6%b3%95%e5%8f%b8%e4%bb%96%ef%bc%89%e6%b2%bb%e7%99%82%e7%97%a4%e7%98%a1%e2%85%a2%e6%9c%9f%e8%87%a8%e5%ba%8a\/16364","name":"\u6b4c\u79ae\u5ba3\u5e03\u555f\u52d5ASC40\uff08\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff09\u6cbb\u7642\u75e4\u7621\u2162\u671f\u81e8\u5e8a\u8a66\u9a57 - \u9999\u6e2f\u7279\u8a31\u7d93\u71df","isPartOf":{"@id":"https:\/\/www.franchise.com.hk\/en#website"},"datePublished":"2023-12-05T00:50:00+00:00","dateModified":"2023-12-05T00:50:00+00:00","breadcrumb":{"@id":"https:\/\/www.franchise.com.hk\/en\/%e6%ad%8c%e7%a6%ae%e5%ae%a3%e5%b8%83%e5%95%9f%e5%8b%95asc40%ef%bc%88%e5%9c%b0%e5%b0%bc%e6%b3%95%e5%8f%b8%e4%bb%96%ef%bc%89%e6%b2%bb%e7%99%82%e7%97%a4%e7%98%a1%e2%85%a2%e6%9c%9f%e8%87%a8%e5%ba%8a\/16364#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.franchise.com.hk\/en\/%e6%ad%8c%e7%a6%ae%e5%ae%a3%e5%b8%83%e5%95%9f%e5%8b%95asc40%ef%bc%88%e5%9c%b0%e5%b0%bc%e6%b3%95%e5%8f%b8%e4%bb%96%ef%bc%89%e6%b2%bb%e7%99%82%e7%97%a4%e7%98%a1%e2%85%a2%e6%9c%9f%e8%87%a8%e5%ba%8a\/16364"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.franchise.com.hk\/en\/%e6%ad%8c%e7%a6%ae%e5%ae%a3%e5%b8%83%e5%95%9f%e5%8b%95asc40%ef%bc%88%e5%9c%b0%e5%b0%bc%e6%b3%95%e5%8f%b8%e4%bb%96%ef%bc%89%e6%b2%bb%e7%99%82%e7%97%a4%e7%98%a1%e2%85%a2%e6%9c%9f%e8%87%a8%e5%ba%8a\/16364#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9801","item":"https:\/\/www.franchise.com.hk\/en"},{"@type":"ListItem","position":2,"name":"\u6b4c\u79ae\u5ba3\u5e03\u555f\u52d5ASC40\uff08\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff09\u6cbb\u7642\u75e4\u7621\u2162\u671f\u81e8\u5e8a\u8a66\u9a57"}]},{"@type":"WebSite","@id":"https:\/\/www.franchise.com.hk\/en#website","url":"https:\/\/www.franchise.com.hk\/en","name":"\u9999\u6e2f\u7279\u8a31\u7d93\u71df","description":"\u9999\u6e2f\u7279\u8a31\u7d93\u71df | Franchise HK","publisher":{"@id":"https:\/\/www.franchise.com.hk\/en#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.franchise.com.hk\/en?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.franchise.com.hk\/en#organization","name":"\u9999\u6e2f\u7279\u8a31\u7d93\u71df","url":"https:\/\/www.franchise.com.hk\/en","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.franchise.com.hk\/en#\/schema\/logo\/image\/","url":"https:\/\/i0.wp.com\/www.franchise.com.hk\/wp-content\/uploads\/2022\/05\/cropped-cropped-franchise-logo-02-e1652686851566-2.png?fit=350%2C76&ssl=1","contentUrl":"https:\/\/i0.wp.com\/www.franchise.com.hk\/wp-content\/uploads\/2022\/05\/cropped-cropped-franchise-logo-02-e1652686851566-2.png?fit=350%2C76&ssl=1","width":350,"height":76,"caption":"\u9999\u6e2f\u7279\u8a31\u7d93\u71df"},"image":{"@id":"https:\/\/www.franchise.com.hk\/en#\/schema\/logo\/image\/"}}]}},"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/www.franchise.com.hk\/en\/wp-json\/wp\/v2\/posts\/16364"}],"collection":[{"href":"https:\/\/www.franchise.com.hk\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.franchise.com.hk\/en\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/www.franchise.com.hk\/en\/wp-json\/wp\/v2\/comments?post=16364"}],"version-history":[{"count":0,"href":"https:\/\/www.franchise.com.hk\/en\/wp-json\/wp\/v2\/posts\/16364\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.franchise.com.hk\/en\/wp-json\/wp\/v2\/media?parent=16364"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.franchise.com.hk\/en\/wp-json\/wp\/v2\/categories?post=16364"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.franchise.com.hk\/en\/wp-json\/wp\/v2\/tags?post=16364"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}