{"id":15638,"date":"2023-11-02T12:39:00","date_gmt":"2023-11-02T04:39:00","guid":{"rendered":"https:\/\/www.franchise.com.hk\/%e4%be%86%e6%81%a9%e7%94%9f%e7%89%a9%e5%96%9c%e7%8d%b22023%e5%b9%b4%e5%ba%a6%e6%96%b0%e5%8a%a0%e5%9d%a1t-up%e5%8d%93%e8%b6%8a%e7%8d%8e\/15638"},"modified":"2023-11-02T12:39:00","modified_gmt":"2023-11-02T04:39:00","slug":"%e4%be%86%e6%81%a9%e7%94%9f%e7%89%a9%e5%96%9c%e7%8d%b22023%e5%b9%b4%e5%ba%a6%e6%96%b0%e5%8a%a0%e5%9d%a1t-up%e5%8d%93%e8%b6%8a%e7%8d%8e","status":"publish","type":"post","link":"https:\/\/www.franchise.com.hk\/en\/%e4%be%86%e6%81%a9%e7%94%9f%e7%89%a9%e5%96%9c%e7%8d%b22023%e5%b9%b4%e5%ba%a6%e6%96%b0%e5%8a%a0%e5%9d%a1t-up%e5%8d%93%e8%b6%8a%e7%8d%8e\/15638","title":{"rendered":"\u4f86\u6069\u751f\u7269\u559c\u73722023\u5e74\u5ea6\u65b0\u52a0\u5761T-Up\u5353\u8d8a\u734e"},"content":{"rendered":"<p>\u65b0\u52a0\u57612023\u5e7411\u67082\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u4f86\u6069\u751f\u7269 (Lion TCR) <span>\u57282023\u5e74\u5ea6\u65b0\u52a0\u5761\u79d1\u6280\u5275\u65b0\u5927\u6703\uff08SWITCH\uff09\u4e0a<\/span>\u559c\u73722023\u5e74\u5ea6\u65b0\u52a0\u5761T-Up\u5353\u8d8a\u734e\u3002\u4f86\u6069\u751f\u7269\u662f\u65b0\u52a0\u5761\u79d1\u6280\u7814\u7a76\u5c40\uff08A*STAR\uff09\u5b75\u5316\u51fa\u4f86\u7684\u81e8\u5e8a\u968e\u6bb5\u7684\u751f\u7269\u6280\u8853\u516c\u53f8\u3002\u8a72\u734e\u9805<span>\u540c\u6642\u4e5f<\/span>\u9812\u767c\u7d66\u4e86\u4f86\u6069\u751f\u7269\u7814\u767c\u90e8\u9580\u9ad8\u7d1a\u7e3d\u76e3\u97cb\u7490\u6069\u535a\u58eb\u53ca\u4f86\u6069\u751f\u7269\u6280\u8853\u751f\u7522\u90e8\u9580\u7e3d\u76e3\u8a31\u66c9\u82b3\u535a\u58eb\uff0c\u4ee5\u8868\u5f70\u5169\u4f4d\u70ba\u4f86\u6069\u751f\u7269\u4e43\u81f3\u65b0\u52a0\u5761\u751f\u7269\u79d1\u6280\u9818\u57df\u7684\u767c\u5c55\u548c\u5275\u65b0\u6240\u4f5c\u51fa\u7684\u5091\u51fa\u8ca2\u737b\u3002\u79d1\u6280\u4f01\u696d\u80fd\u529b\u5347\u7d1a\uff08T-Up\uff09\u662f\u65b0\u52a0\u5761\u79d1\u6280\u7814\u7a76\u5c40\u6280\u8853\u5347\u7d1a\u4fc3\u4f01\u696d\u6210\u9577\u8a08\u5283\uff08GET-Up\uff09\u7684\u4e00\u90e8\u5206\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\">\n<p><a href=\"https:\/\/mma.prnasia.com\/media2\/2264643\/image_1.html\" target=\"_blank\" rel=\"noopener\"><\/a><br \/><span>\u9812\u734e\u73fe\u5834\uff1a\u65b0\u52a0\u5761\u8cbf\u5de5\u90e8\u90e8\u9577\u984f\u91d1\u52c7 (Gan Kim Yong)\uff08\u524d\u6392\u5de6\u4e09\uff09\u3001\u65b0\u52a0\u5761\u4f01\u696d\u767c\u5c55\u5c40\u4e3b\u5e2d\u738b\u6587\u8f1d\uff08Peter Ong\uff09\uff08\u524d\u6392\u5de6\u56db\uff09\u3001\u65b0\u52a0\u5761\u79d1\u6280\u7814\u7a76\u5c40(A*STAR)\u9996\u5e2d\u57f7\u884c\u5b98\u5468\u7e7c\u5f37\uff08Frederick Chew\uff09(\u5f8c\u6392\u5de6\u4e8c)\u3001\u4f86\u6069\u751f\u7269\u9996\u5e2d\u57f7\u884c\u5b98\u5f6d\u66c9\u660e\uff08\u5f8c\u6392\u53f3\u4e00\uff09\u3001\u4f86\u6069\u751f\u7269\u9ad8\u7d1a\u7e3d\u76e3\u97cb\u7490\u6069\uff08\u524d\u6392\u53f3\u56db\uff09\u3001\u4f86\u6069\u751f\u7269\u7e3d\u76e3\u8a31\u66c9\u82b3\uff08\u524d\u6392\u53f3\u4e09\uff09<\/span><\/p>\n<\/div>\n<p>GET-Up\u8a08\u5283\u65e8\u5728\u63d0\u5347\u65b0\u52a0\u5761\u79d1\u6280\u5bc6\u96c6\u578b\u4f01\u696d\u7684\u7af6\u722d\u529b\uff0c\u70ba\u4f01\u696d\u63d0\u4f9b\u77e5\u8b58\u578b\u7d93\u6fdf\u6240\u9700\u7684\u6280\u80fd\u548c\u5c08\u696d\u77e5\u8b58\u3002GET-Up\u8a08\u5283\u6709\u4e09\u9805\u5021\u8b70\uff1a<\/p>\n<p>\u79d1\u6280\u4f01\u696d\u80fd\u529b\u5347\u7d1a \uff08T-Up\uff09\uff1a\u901a\u904eT-Up\uff0c\u65b0\u52a0\u5761\u4f01\u696d\u80fd\u5920\u5229\u7528\u65b0\u52a0\u5761\u79d1\u6280\u7814\u7a76\u5c40\u7684\u7814\u7a76\u8cc7\u6e90\uff0c\u5e6b\u52a9\u63d0\u5347\u7814\u767c\u80fd\u529b\uff0c\u5275\u9020\u80fd\u5920\u7372\u5f97\u5546\u696d\u50f9\u503c\u7684\u524d\u6cbf\u6280\u8853<br \/>\n\u6280\u8853\u9867\u554f\uff08TA\uff09\uff1a\u70ba\u78ba\u4fdd\u65b0\u52a0\u5761\u4f01\u696d\u5728\u8f49\u578b\u904e\u7a0b\u4e2d\u6301\u7e8c\u53d6\u5f97\u6210\u529f\uff0c\u65b0\u52a0\u5761\u79d1\u6280\u7814\u7a76\u5c40\u4ea6\u63d0\u4f9b\u8cc7\u6df1\u5c08\u5bb6\u64d4\u4efb\u4f01\u696d\u6280\u8853\u9867\u554f\uff0c\u5354\u52a9\u4f01\u696d\u9032\u884c\u6280\u8853\u898f\u5283\u548c\u7b56\u7565\u5236\u5b9a<br \/>\n\u71df\u904b\u53ca\u6280\u8853\u767c\u5c55\u85cd\u5716\uff08OTR\uff09\uff1aOTR\u662f\u7531\u65b0\u52a0\u5761\u79d1\u6280\u7814\u7a76\u5c40\u63a8\u52d5\u7684\u6230\u7565\u6aa2\u8a0e\u5de5\u4f5c\uff0c\u65b0\u52a0\u5761\u4f01\u696d\u7ba1\u7406\u5c64\u7a4d\u6975\u53c3\u8207\uff0c\u6aa2\u8a0e\u4f01\u696d\u7684\u696d\u52d9\u904b\u71df\u53ca\u6280\u8853\u80fd\u529b\uff0c\u4ee5\u61c9\u5c0d\u672a\u4f86\u7684\u6311\u6230\u53ca\u958b\u62d3\u65b0\u5e02\u5834  <\/p>\n<p>\u4f86\u6069\u751f\u7269\u9996\u5e2d\u57f7\u884c\u5b98\u5f6d\u66c9\u660e\u535a\u58eb\u5c0d\u4f86\u6069\u751f\u7269\u559c\u73722023\u5e74\u65b0\u52a0\u5761T-Up \u5353\u8d8a\u734e\u8868\u793a\u795d\u8cc0\uff0c\u4e5f\u611f\u8b1d\u97cb\u7490\u6069\u535a\u58eb\u4ee5\u53ca\u8a31\u66c9\u82b3\u535a\u58eb\u7684\u5353\u8d8a\u8ca2\u737b<span>\u3002\u97cb\u7490\u6069\u535a\u58eb\u548c\u8a31\u66c9\u82b3\u535a\u58eb\u4e5f\u662f\u65b0\u52a0\u5761\u79d1\u6280\u7814\u7a76\u5c40\u734e\u5b78\u91d1\u5f97\u4e3b\uff0c\u5206\u5225\u7372\u5f97\u7f8e\u570b\u65af\u5766\u798f\u5927\u5b78\u548c\u745e\u5178\u7684\u5361\u7f85\u6797\u65af\u5361\u5927\u5b78\u7684\u535a\u58eb\u5b78\u4f4d\uff0c<\/span>\u9019\u500b\u734e\u9805\u5c07\u6210\u70ba\u4f86\u6069\u751f\u7269\u9032\u4e00\u6b65\u63d0\u5347\u79d1\u6280\u7684\u50ac\u5316\u5291\uff1a\u300c \u65b0\u52a0\u5761\u79d1\u6280\u7814\u7a76\u5c40\u63a8\u52d5\u7684T-Up\u8a08\u5283\u5c0d\u63d0\u5347\u4f86\u6069\u751f\u7269\u7684\u7814\u767c\u80fd\u529b\u548c\u7a81\u7834\u57fa\u65bcmRNA\u7684T\u7d30\u80de\u514d\u75ab\u7642\u6cd5\u7684\u9032\u7a0b\u8d77\u5230\u4e86\u91cd\u8981\u4f5c\u7528\u3002\u300d \u5f6d\u535a\u58eb\u8868\u793a\u3002\u300c \u65b0\u52a0\u5761\u79d1\u6280\u7814\u7a76\u5c40\u7684\u4eba\u624d\u5728\u9019\u65b9\u9762\u4f5c\u51fa\u4e86\u5091\u51fa\u7684\u8ca2\u737b\uff0c\u4e0d\u50c5\u63d0\u5347\u4e86\u4f86\u6069\u751f\u7269\u7684\u7814\u767c\u80fd\u529b\uff0c\u4e5f\u978f\u56fa\u4e86\u65b0\u52a0\u5761\u4f5c\u70ba\u751f\u7269\u6280\u8853\u5275\u65b0\u6a1e\u7d10\u7684\u5730\u4f4d\u3002\u9019\u4e9b\u52aa\u529b\u5927\u5927\u52a0\u901f\u4e86\u6280\u8853\u5275\u65b0\u53ca\u7814\u767c\uff0c\u4e26\u50ac\u751f\u4e86\u5275\u65b0\u7522\u54c1\u548c\u76f8\u95dc\u77e5\u8b58\u7522\u6b0a\u3002\u6b64\u5916\uff0c\u4e5f\u986f\u8457\u63a8\u52d5\u4e86\u696d\u52d9\u62d3\u5c55\uff0c\u63d0\u9ad8\u4e86\u904b\u71df\u6548\u7387\uff0c\u4e26\u4fc3\u9032\u4e86\u4f86\u6069\u751f\u7269\u7684\u5168\u7403\u696d\u52d9\u62d3\u5c55\u3002\u300d\u00a0<\/p>\n<p>\u4eca\u5e7410\u6708\uff0cKatalin Kariko\u548cDrew Weissman\u56e0\u5176\u5728mRNA\u75ab\u82d7\u7814\u7a76\u65b9\u9762\u7684\u7a81\u7834\u6027\u6210\u5c31\u7372\u5f97\u4e86\u8afe\u8c9d\u723e\u751f\u7406\u5b78\u6216\u91ab\u5b78\u734e\uff0c\u9019\u70baModerna\u516c\u53f8\u4ee5\u53ca\u8f1d\u745e\u516c\u53f8\u8207BioNTech \u516c\u53f8\u75ab\u82d7\u7684\u5408\u4f5c\u5960\u5b9a\u4e86\u57fa\u790e\u3002mRNA\u6280\u8853\u7684\u4e00\u500b\u9769\u547d\u6027\u61c9\u7528\u662f\u5229\u7528\u5176\u9032\u884c\u6297\u764c\u6cbb\u7642\uff0c\u9019\u4ecd\u7136\u662f\u5168\u7403\u5c1a\u672a\u6eff\u8db3\u7684\u91ab\u7642\u9700\u6c42\u3002\u4f86\u6069\u751f\u7269\u5229\u7528mRNA\u7de8\u78bcTCR\uff0c\u70ba\u809d\u764c\u7684\u524d\u6cbf\u7d30\u80de\u7642\u6cd5\u63d0\u4f9b\u89e3\u6c7a\u65b9\u6848\u3002<span>\u4f86\u6069\u751f\u7269<\/span>\u7684FIRST-IN-CLASS HBV\u7279\u7570\u6027TCR-T\u7d30\u80de\u7642\u6cd5\u4f5c\u70ba\u5b89\u5168\u6709\u6548\u7684\u6cbb\u7642\u624b\u6bb5\uff0c\u5df2\u521d\u6b65\u986f\u793a\u51fa\u6cbb\u7642\u6f5b\u529b\u3002\u66f4\u5177\u6709\u524d\u666f\u7684\u662f\uff0cmRNA\u6280\u8853\u70ba\u300c \u73fe\u8ca8\u578b\u300d \u514d\u75ab\u7d30\u80de\u7642\u6cd5\u92ea\u5e73\u4e86\u9053\u8def\u3002\u9019\u7a2e\u5275\u65b0\u65b9\u6cd5\u53ef\u4ee5\u5728\u9ad4\u5167\u751f\u6210TCR-T\u7d30\u80de\uff0c\u70ba\u66f4\u6613\u7372\u5f97\u548c\u66f4\u5177\u6709\u6210\u672c\u512a\u52e2\u7684\u6cbb\u7642\u958b\u95e2\u4e86\u53ef\u80fd\u6027\u3002T-Up\u8a08\u5283\u4e0b\u57f9\u80b2\u7684\u5091\u51fa\u4eba\u624d\u4f8b\u5982\u97cb\u7490\u6069\u535a\u58eb\u548c\u8a31\u66c9\u82b3\u535a\u58eb\uff0c\u5728\u63a8\u52d5\u4f86\u6069\u751f\u7269\u7522\u54c1\u9032\u7a0b\u65b9\u9762\u767c\u63ee\u4e86\u95dc\u9375\u4f5c\u7528\uff0c\u4e26\u70ba\u57fa\u65bcmRNA\u7684T\u7d30\u80de\u514d\u75ab\u7642\u6cd5\u7684\u63a8\u9032\u548c\u5275\u65b0\u4f5c\u51fa\u4e86\u8ca2\u737b\u3002\u5979\u5011\u7684\u5c08\u696d\u77e5\u8b58\u548c\u5949\u737b\u7cbe\u795e\u4e5f\u52a0\u901f\u4e86\u6211\u5011\u8d70\u5411\u7a81\u7834\u6027\u764c\u75c7\u7642\u6cd5\u7684\u9032\u7a0b\u3002<\/p>\n<p>\u65b0\u52a0\u5761T-Up\u5353\u8d8a\u734e\u8868\u5f70\u4e86\u65b0\u52a0\u5761\u79d1\u6280\u7814\u7a76\u5c40\u57f9\u8a13\u7684\u4eba\u624d\u5728\u4fc3\u9032\u65b0\u52a0\u5761\u4f01\u696d\u5275\u65b0\u548c\u589e\u9577\u4e2d\u6240\u767c\u63ee\u7684\u5bf6\u8cb4\u4f5c\u7528\u3002\u4f86\u6069\u751f\u7269\u5f88\u69ae\u5e78\u7372\u5f97\u9019\u4e00\u734e\u9805\uff0c\u4e26\u671f\u5f85\u5728\u751f\u7269\u79d1\u6280\u884c\u696d\u7e7c\u7e8c\u5176\u8b8a\u9769\u6027\u7684\u5de5\u4f5c\uff0c\u63a8\u9032\u57fa\u65bcmRNA\u7684T\u7d30\u80de\u514d\u75ab\u7642\u6cd5\u653b\u514b\u816b\u7624\uff0c\u9020\u798f\u793e\u6703\u3002<\/p>\n<p>\u6700\u5f8c\uff0c<span>\u5f88\u9ad8\u8208\u5206\u4eab\u4f86\u6069\u751f\u7269\u8207<\/span>\u65b0\u52a0\u5761\u79d1\u6280\u7814\u7a76\u5c40\u5171\u540c\u767c\u8868\u7684\u4e00\u7bc7\u6587\u7ae0\u3002\u9019\u7bc7\u6587\u7ae0\u63ed\u793a\u4e86\u4f86\u6069\u751f\u7269\u9769\u547d\u6027\u7684\u764c\u75c7\u7642\u6cd5\u7684\u80cc\u5f8c\u539f\u7406\u3002\u66f4\u591a\u8a73\u60c5\uff0c<span>\u53ef\u4ee5<\/span>\u5728<a href=\"https:\/\/www.a-star.edu.sg\/News\/a-star-innovate\/innovates\/innovate\/the-formula-behind-lion-tcr&#039;s-lifechanging-cancer-therapy\" target=\"_blank\" rel=\"noopener\">\u9019\u88e1<\/a>\u95b1\u8b80\u9019\u7bc7\u6587\u7ae0\u7684\u7d30\u7bc0\u3002<\/p>\n<p>\u95dc\u65bc\u4f86\u6069\u751f\u7269\uff08Lion TCR\uff09<\/p>\n<p>\u4f5c\u70ba\u65b0\u52a0\u5761\u79d1\u6280\u7814\u7a76\u5c40\u5b75\u5316\u51fa\u4f86\u7684\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u4f86\u6069\u751f\u7269\u5c08\u9580\u5f9e\u4e8b\u958b\u767c\u611f\u67d3\u985e\u75be\u75c5\u548c\u816b\u7624\u76f8\u95dc\u75be\u75c5\u7684\u5de5\u7a0b\u5316T\u7d30\u80de\u53d7\u9ad4\u7d30\u80de\u7642\u6cd5\uff08TCR-T\uff09\uff0c\u5c24\u5176\u662f\u8207HBV\u76f8\u95dc\u7684\u809d\u7d30\u80de\u764c\uff08HCC\uff09\u3002\u4f86\u6069\u751f\u7269\u5df2\u7d93\u7372\u5f97\u4e86FDA <span class=\"xn-money\">1b<\/span>\/2\u671f\u81e8\u5e8a\u8a66\u9a57\u7684IND\u6279\u4ef6\u2014\u9019\u662f\u4e16\u754c\u4e0a\u7b2c\u4e00\u500bFDA\u6279\u51c6\u7684\u9776\u5411HBV TCR-T\u7642\u6cd5\uff08LioCyx-M004\uff09\u7684\u570b\u969b\u591a\u4e2d\u5fc3\u81e8\u5e8a\u8a66\u9a57\uff0c\u7528\u65bc\u6cbb\u7642HCC\u3002\u6b64\u5916\uff0cLioCyx-M004\u5df2\u7372\u5f97FDA\u7684\u5feb\u901f\u901a\u9053\u548c\u5b64\u5152\u85e5\u7684\u96d9\u91cd\u8a8d\u5b9a\u3002\u4f86\u6069\u751f\u7269\u958b\u5275\u6027\u7684\u65b9\u6cd5\u5305\u62ec\u5229\u7528mRNA\u5728\u60a3\u8005T\u7d30\u80de\u4e2d\u7de8\u78bcHBV\u7279\u7570\u6027TCR\uff0c\u4f7f\u5176\u80fd\u5920\u9776\u5411\u809d\u764c\u7d30\u80de\u4e2d\u8868\u9054\u7684HBV\u8868\u4f4d\u3002\u81e8\u5e8a\u8a66\u9a57\u7d50\u679c\u8b49\u660e\u4e86\u5176\u826f\u597d\u7684\u5b89\u5168\u6027\u53ca\u986f\u8457\u7642\u6548\u3002\u4f86\u6069\u751f\u7269\u6191\u501f\u5176mRNA\u6280\u8853\u548c<span>AI<\/span><span>\u8ce6\u80fd<\/span>\u7684TCR\u767c\u73fe\u5e73\u53f0\uff0c\u53ef\u4ee5\u64f4\u5c55\u5230\u5176\u4ed6\u5be6\u9ad4\u816b\u7624\u9818\u57df\uff0c\u63d0\u4f9b\u4e86\u500b\u6027\u5316\u7684\u7d30\u80de\u7642\u6cd5\u548c\u300c \u73fe\u8ca8\u578b\u300d \u7522\u54c1\u89e3\u6c7a\u65b9\u6848\uff0c\u958b\u767c\u51fa\u8c50\u5bcc\u7684\u7ba1\u7dda\uff0c\u7528\u65bc\u6cbb\u7642\u5404\u7a2e\u5be6\u9ad4\u816b\u7624\u548c\u6162\u6027\u75c5\u6bd2\u611f\u67d3\u75be\u75c5\u3002\u4f86\u6069\u751f\u7269\u7a4d\u6975\u63a8\u52d5\u516c\u53f8\u7684\u570b\u969b\u5316\u6230\u7565\uff0c\u5728\u5ee3\u5dde\u4e2d\u65b0\u77e5\u8b58\u57ce\u8a2d\u7acb\u4e86\u4e2d\u570b\u7e3d\u90e8\uff0c\u6574\u5408\u7814\u767c\u3001\u81e8\u5e8a\u904b\u71df\u548cGMP\u751f\u7522\u70ba\u4e00\u9ad4\u7684\u591a\u529f\u80fd\u6a1e\u7d10\uff0c\u52a0\u5feb\u5c07\u5275\u65b0\u7522\u54c1\u5f15\u5165\u4e2d\u570b\u5e02\u5834\u3002<\/p>\n<p>\u95dc\u65bc\u65b0\u52a0\u5761\u79d1\u6280\u7814\u7a76\u5c40\uff08A*STAR\uff09<\/p>\n<p>\u65b0\u52a0\u5761\u79d1\u6280\u7814\u7a76\u5c40\uff08A*STAR\uff09\u662f\u65b0\u52a0\u5761\u81f4\u529b\u65bc\u4efb\u52d9\u5c0e\u5411\u578b\u7814\u7a76\uff0c\u63a8\u52d5\u79d1\u5b78\u767c\u73fe\u3001\u6280\u8853\u5275\u65b0\u548c\u7d93\u6fdf\u589e\u9577\u7684\u570b\u969b\u9818\u5148\u7d44\u7e54\u3002\u4ee5\u57f9\u990a\u4eba\u624d\u548c\u4fc3\u9032\u5408\u4f5c\u5925\u4f34\u95dc\u4fc2\u70ba\u91cd\u5fc3\uff0cA*STAR\u5c07\u5b78\u8853\u754c\u548c\u7522\u696d\u754c\u7dca\u5bc6\u806f\u7e6b\u5728\u4e00\u8d77\uff0c\u5b8c\u6210\u6709\u5f71\u97ff\u529b\u7684\u6210\u679c\uff0c\u70ba\u793e\u6703\u5e36\u4f86\u798f\u5229\u3002A*STAR\u7684\u9858\u666f\u662f\u6210\u70ba\u79d1\u5b78\u3001\u6280\u8853\u548c\u958b\u653e\u5275\u65b0\u7684\u5168\u7403\u9818\u5c0e\u8005\uff0c\u63a8\u52d5\u9020\u798f\u65bc\u7d93\u6fdf\u548c\u793e\u6703\u7684\u91cd\u8981\u7814\u7a76\u7d44\u7e54\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\">\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u65b0\u52a0\u57612023\u5e7411\u67082\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u4f86\u6069\u751f\u7269 (Lion TCR) \u57282023\u5e74\u5ea6\u65b0\u52a0\u5761\u79d1\u6280\u5275\u65b0\u5927\u6703\uff08SWITCH\uff09\u4e0a\u559c\u73722023\u5e74\u5ea6\u65b0\u52a0\u5761T-Up\u5353\u8d8a\u734e\u3002\u4f86\u6069\u751f\u7269\u662f\u65b0\u52a0\u5761\u79d1\u6280\u7814\u7a76\u5c40\uff08A*STAR\uff09\u5b75\u5316\u51fa\u4f86\u7684\u81e8\u5e8a\u968e\u6bb5\u7684\u751f\u7269\u6280\u8853\u516c\u53f8\u3002\u8a72\u734e\u9805\u540c\u6642\u4e5f\u9812\u767c\u7d66\u4e86\u4f86\u6069\u751f\u7269\u7814\u767c\u90e8\u9580\u9ad8\u7d1a\u7e3d\u76e3\u97cb\u7490\u6069\u535a\u58eb\u53ca\u4f86\u6069\u751f\u7269\u6280\u8853\u751f\u7522\u90e8\u9580\u7e3d\u76e3\u8a31\u66c9\u82b3\u535a\u58eb\uff0c\u4ee5\u8868\u5f70\u5169\u4f4d\u70ba\u4f86\u6069\u751f\u7269\u4e43\u81f3\u65b0\u52a0\u5761\u751f\u7269\u79d1\u6280\u9818\u57df\u7684\u767c\u5c55\u548c\u5275\u65b0\u6240\u4f5c\u51fa\u7684\u5091\u51fa\u8ca2\u737b\u3002\u79d1\u6280\u4f01\u696d\u80fd\u529b\u5347\u7d1a\uff08T-Up\uff09\u662f\u65b0\u52a0\u5761\u79d1\u6280\u7814\u7a76\u5c40\u6280\u8853\u5347\u7d1a\u4fc3\u4f01\u696d\u6210\u9577\u8a08\u5283\uff08GET-Up\uff09\u7684\u4e00\u90e8\u5206\u3002 \u9812\u734e\u73fe\u5834\uff1a\u65b0\u52a0\u5761\u8cbf\u5de5\u90e8\u90e8\u9577\u984f\u91d1\u52c7 (Gan Kim Yong)\uff08\u524d\u6392\u5de6\u4e09\uff09\u3001\u65b0\u52a0\u5761\u4f01\u696d\u767c\u5c55\u5c40\u4e3b\u5e2d\u738b\u6587\u8f1d\uff08Peter Ong\uff09\uff08\u524d\u6392\u5de6\u56db\uff09\u3001\u65b0\u52a0\u5761\u79d1\u6280\u7814\u7a76\u5c40(A*STAR)\u9996\u5e2d\u57f7\u884c\u5b98\u5468\u7e7c\u5f37\uff08Frederick Chew\uff09(\u5f8c\u6392\u5de6\u4e8c)\u3001\u4f86\u6069\u751f\u7269\u9996\u5e2d\u57f7\u884c\u5b98\u5f6d\u66c9\u660e\uff08\u5f8c\u6392\u53f3\u4e00\uff09\u3001\u4f86\u6069\u751f\u7269\u9ad8\u7d1a\u7e3d\u76e3\u97cb\u7490\u6069\uff08\u524d\u6392\u53f3\u56db\uff09\u3001\u4f86\u6069\u751f\u7269\u7e3d\u76e3\u8a31\u66c9\u82b3\uff08\u524d\u6392\u53f3\u4e09\uff09 GET-Up\u8a08\u5283\u65e8\u5728\u63d0\u5347\u65b0\u52a0\u5761\u79d1\u6280\u5bc6\u96c6\u578b\u4f01\u696d\u7684\u7af6\u722d\u529b\uff0c\u70ba\u4f01\u696d\u63d0\u4f9b\u77e5\u8b58\u578b\u7d93\u6fdf\u6240\u9700\u7684\u6280\u80fd\u548c\u5c08\u696d\u77e5\u8b58\u3002GET-Up\u8a08\u5283\u6709\u4e09\u9805\u5021\u8b70\uff1a \u79d1\u6280\u4f01\u696d\u80fd\u529b\u5347\u7d1a \uff08T-Up\uff09\uff1a\u901a\u904eT-Up\uff0c\u65b0\u52a0\u5761\u4f01\u696d\u80fd\u5920\u5229\u7528\u65b0\u52a0\u5761\u79d1\u6280\u7814\u7a76\u5c40\u7684\u7814\u7a76\u8cc7\u6e90\uff0c\u5e6b\u52a9\u63d0\u5347\u7814\u767c\u80fd\u529b\uff0c\u5275\u9020\u80fd\u5920\u7372\u5f97\u5546\u696d\u50f9\u503c\u7684\u524d\u6cbf\u6280\u8853 \u6280\u8853\u9867\u554f\uff08TA\uff09\uff1a\u70ba\u78ba\u4fdd\u65b0\u52a0\u5761\u4f01\u696d\u5728\u8f49\u578b\u904e\u7a0b\u4e2d\u6301\u7e8c\u53d6\u5f97\u6210\u529f\uff0c\u65b0\u52a0\u5761\u79d1\u6280\u7814\u7a76\u5c40\u4ea6\u63d0\u4f9b\u8cc7\u6df1\u5c08\u5bb6\u64d4\u4efb\u4f01\u696d\u6280\u8853\u9867\u554f\uff0c\u5354\u52a9\u4f01\u696d\u9032\u884c\u6280\u8853\u898f\u5283\u548c\u7b56\u7565\u5236\u5b9a \u71df\u904b\u53ca\u6280\u8853\u767c\u5c55\u85cd\u5716\uff08OTR\uff09\uff1aOTR\u662f\u7531\u65b0\u52a0\u5761\u79d1\u6280\u7814\u7a76\u5c40\u63a8\u52d5\u7684\u6230\u7565\u6aa2\u8a0e\u5de5\u4f5c\uff0c\u65b0\u52a0\u5761\u4f01\u696d\u7ba1\u7406\u5c64\u7a4d\u6975\u53c3\u8207\uff0c\u6aa2\u8a0e\u4f01\u696d\u7684\u696d\u52d9\u904b\u71df\u53ca\u6280\u8853\u80fd\u529b\uff0c\u4ee5\u61c9\u5c0d\u672a\u4f86\u7684\u6311\u6230\u53ca\u958b\u62d3\u65b0\u5e02\u5834 \u4f86\u6069\u751f\u7269\u9996\u5e2d\u57f7\u884c\u5b98\u5f6d\u66c9\u660e\u535a\u58eb\u5c0d\u4f86\u6069\u751f\u7269\u559c\u73722023\u5e74\u65b0\u52a0\u5761T-Up \u5353\u8d8a\u734e\u8868\u793a\u795d\u8cc0\uff0c\u4e5f\u611f\u8b1d\u97cb\u7490\u6069\u535a\u58eb\u4ee5\u53ca\u8a31\u66c9\u82b3\u535a\u58eb\u7684\u5353\u8d8a\u8ca2\u737b\u3002\u97cb\u7490\u6069\u535a\u58eb\u548c\u8a31\u66c9\u82b3\u535a\u58eb\u4e5f\u662f\u65b0\u52a0\u5761\u79d1\u6280\u7814\u7a76\u5c40\u734e\u5b78\u91d1\u5f97\u4e3b\uff0c\u5206\u5225\u7372\u5f97\u7f8e\u570b\u65af\u5766\u798f\u5927\u5b78\u548c\u745e\u5178\u7684\u5361\u7f85\u6797\u65af\u5361\u5927\u5b78\u7684\u535a\u58eb\u5b78\u4f4d\uff0c\u9019\u500b\u734e\u9805\u5c07\u6210\u70ba\u4f86\u6069\u751f\u7269\u9032\u4e00\u6b65\u63d0\u5347\u79d1\u6280\u7684\u50ac\u5316\u5291\uff1a\u300c \u65b0\u52a0\u5761\u79d1\u6280\u7814\u7a76\u5c40\u63a8\u52d5\u7684T-Up\u8a08\u5283\u5c0d\u63d0\u5347\u4f86\u6069\u751f\u7269\u7684\u7814\u767c\u80fd\u529b\u548c\u7a81\u7834\u57fa\u65bcmRNA\u7684T\u7d30\u80de\u514d\u75ab\u7642\u6cd5\u7684\u9032\u7a0b\u8d77\u5230\u4e86\u91cd\u8981\u4f5c\u7528\u3002\u300d \u5f6d\u535a\u58eb\u8868\u793a\u3002\u300c \u65b0\u52a0\u5761\u79d1\u6280\u7814\u7a76\u5c40\u7684\u4eba\u624d\u5728\u9019\u65b9\u9762\u4f5c\u51fa\u4e86\u5091\u51fa\u7684\u8ca2\u737b\uff0c\u4e0d\u50c5\u63d0\u5347\u4e86\u4f86\u6069\u751f\u7269\u7684\u7814\u767c\u80fd\u529b\uff0c\u4e5f\u978f\u56fa\u4e86\u65b0\u52a0\u5761\u4f5c\u70ba\u751f\u7269\u6280\u8853\u5275\u65b0\u6a1e\u7d10\u7684\u5730\u4f4d\u3002\u9019\u4e9b\u52aa\u529b\u5927\u5927\u52a0\u901f\u4e86\u6280\u8853\u5275\u65b0\u53ca\u7814\u767c\uff0c\u4e26\u50ac\u751f\u4e86\u5275\u65b0\u7522\u54c1\u548c\u76f8\u95dc\u77e5\u8b58\u7522\u6b0a\u3002\u6b64\u5916\uff0c\u4e5f\u986f\u8457\u63a8\u52d5\u4e86\u696d\u52d9\u62d3\u5c55\uff0c\u63d0\u9ad8\u4e86\u904b\u71df\u6548\u7387\uff0c\u4e26\u4fc3\u9032\u4e86\u4f86\u6069\u751f\u7269\u7684\u5168\u7403\u696d\u52d9\u62d3\u5c55\u3002\u300d\u00a0 \u4eca\u5e7410\u6708\uff0cKatalin Kariko\u548cDrew Weissman\u56e0\u5176\u5728mRNA\u75ab\u82d7\u7814\u7a76\u65b9\u9762\u7684\u7a81\u7834\u6027\u6210\u5c31\u7372\u5f97\u4e86\u8afe\u8c9d\u723e\u751f\u7406\u5b78\u6216\u91ab\u5b78\u734e\uff0c\u9019\u70baModerna\u516c\u53f8\u4ee5\u53ca\u8f1d\u745e\u516c\u53f8\u8207BioNTech \u516c\u53f8\u75ab\u82d7\u7684\u5408\u4f5c\u5960\u5b9a\u4e86\u57fa\u790e\u3002mRNA\u6280\u8853\u7684\u4e00\u500b\u9769\u547d\u6027\u61c9\u7528\u662f\u5229\u7528\u5176\u9032\u884c\u6297\u764c\u6cbb\u7642\uff0c\u9019\u4ecd\u7136\u662f\u5168\u7403\u5c1a\u672a\u6eff\u8db3\u7684\u91ab\u7642\u9700\u6c42\u3002\u4f86\u6069\u751f\u7269\u5229\u7528mRNA\u7de8\u78bcTCR\uff0c\u70ba\u809d\u764c\u7684\u524d\u6cbf\u7d30\u80de\u7642\u6cd5\u63d0\u4f9b\u89e3\u6c7a\u65b9\u6848\u3002\u4f86\u6069\u751f\u7269\u7684FIRST-IN-CLASS 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