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class=\"xn-money\">1b<\/span>)\u6578\u64da\u4e5f\u66fe\u57282022\u5e74\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\u4e0a\u516c\u5e03\u3002\u6578\u64da\u986f\u793a\uff0cnofazinlimab\u806f\u5408\u4f96\u4f10\u66ff\u5c3c\u4e00\u7dda\u6cbb\u7642\u4e0d\u53ef\u5207\u9664\u665a\u671f\u809d\u7d30\u80de\u764c\u60a3\u8005\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u9054\u523045%\uff1b\u4e2d\u4f4d\u6301\u7e8c\u7de9\u89e3\u6642\u9593\uff08DoR\uff09\u81f3\u6578\u64da\u622a\u6b62\u6642\u4ecd\u672a\u9054\u5230\uff0c\u7bc4\u570d\u70ba4.2\u81f318.7+\u500b\u6708\uff1b\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u70ba10.4\u500b\u6708\uff1b\u5b89\u5168\u6027\u8010\u53d7\u826f\u597d\u3002<\/p>\n<p>\u95dc\u65bcnofazinlimab<\/p>\n<p>Nofazinlimab\u662f\u4e00\u7a2e\u9776\u5411\u4eba\u7a0b\u5e8f\u6027\u7d30\u80de\u6b7b\u4ea1\u86cb\u767d1\uff08PD-1\uff09\u7684\u4eba\u6e90\u5316\u91cd\u7d44IgG4\u55ae\u514b\u9686\u6297\u9ad4\uff0c\u6b63\u5728\u958b\u767c\u7528\u65bc\u816b\u7624\u7684\u514d\u75ab\u6cbb\u7642\u3002Nofazinlimab\u8207\u4eba\u985e\u3001\u98df\u87f9\u7334\u548c\u5c0f\u9f20PD-1\u5747\u5177\u6709\u9ad8\u89aa\u548c\u529b\uff0c\u53ef\u963b\u65b7PD-1\u8207PD-L1\u548cPD-L2\u914d\u9ad4\u7684\u76f8\u4e92\u4f5c\u7528\u3002<br \/>Nofazinlimab\u5df2\u65bc2020\u5e747\u6708\u7372\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6388\u4e88\u5b64\u5152\u85e5\u8cc7\u683c\uff08Orphan Drug Designation\uff0cODD\uff09\uff0c\u7528\u65bc\u6cbb\u7642\u809d\u7d30\u80de\u764c\u3002<br \/>2022\u5e743\u6708\uff0cnofazinlimab\u806f\u5408\u4f96\u4f10\u66ff\u5c3c\u4e00\u7dda\u6cbb\u7642\u665a\u671f\u809d\u7d30\u80de\u764c\u60a3\u8005\u7684\u570b\u969b\u591a\u4e2d\u5fc3III\u671f\u8a3b\u518a\u6027\u7814\u7a76CS1003-305\u6210\u529f\u9054\u6210\u9810\u8a2d\u60a3\u8005\u5165\u7d44\u76ee\u6a19\u3002<\/p>\n<p>\u95dc\u65bc\u809d\u7d30\u80de\u764c\uff08HCC\uff09<\/p>\n<p>\u809d\u764c\u662f\u5168\u7403\u7bc4\u570d\u5167\u5e38\u898b\u7684\u6d88\u5316\u7cfb\u7d71\u60e1\u6027\u816b\u7624\uff0c\u6839\u64da\u4e16\u754c\u885b\u751f\u7d44\u7e54\u570b\u969b\u764c\u7665\u7814\u7a76\u6240(IARC)\u516c\u5e03\u7684\u300c\u5168\u7403\u816b\u7624\u6d41\u884c\u75c5\u7d71\u8a08\u6578\u64da(GLOBOCAN)2020\u300d\u986f\u793a\uff0c2020\u5e74\u5168\u7403\u88ab\u65b0\u78ba\u8a3a\u70ba\u809d\u764c\u7684\u4eba\u6578\u8d85\u904e90\u842c\uff0c\u56e0\u809d\u764c\u6b7b\u4ea1\u7684\u4eba\u6578\u8d85\u904e83\u842c\uff0c\u6b7b\u4ea1\u4eba\u6578\u63a5\u8fd1\u65b0\u767c\u75c5\u4eba\u6578\u3002\u809d\u764c\u662f\u764c\u7665\u76f8\u95dc\u6b7b\u4ea1\u7684\u7b2c\u4e8c\u5927\u539f\u56e0\uff0c\u5176\u767c\u75c5\u7387\u5728\u5168\u7403\u7bc4\u570d\u5167\u5448\u4e0a\u5347\u8da8\u52e2 <span>[1]<\/span>\u3002\u809d\u764c\u7684\u75c5\u7406\u985e\u578b\u4ee5HCC\u6700\u70ba\u5e38\u898b\uff0c\u7d04\u536090%<span>\u00a0[2]<\/span>\u3002\u7cfb\u7d71\u6297\u816b\u7624\u6cbb\u7642\u5728\u665a\u671fHCC\u7684\u6cbb\u7642\u4e2d\u767c\u63ee\u4e86\u91cd\u8981\u7684\u4f5c\u7528\u3002\u76e1\u7ba1\u5916\u79d1\u6cbb\u7642\u548c\u5c40\u90e8\u6cbb\u7642\u5728\u4e16\u754c\u7bc4\u570d\u5167\u7684\u61c9\u7528\u8d8a\u4f86\u8d8a\u5ee3\u6cdb\uff0c\u4f46\u64da\u4f30\u8a08\uff0c\u7d0450-60%\u7684HCC\u60a3\u8005\u6700\u7d42\u5c07\u63a5\u53d7\u7cfb\u7d71\u6cbb\u7642<span>[1]<\/span>\u3002\u63a5\u53d7\u7cfb\u7d71\u6cbb\u7642\u7684\u665a\u671fHCC\u75c5\u4f8b\u7684\u4e2d\u4f4d\u751f\u5b58\u671f\u7d04\u70ba1-1.5\u5e74<span>[2]<\/span>\u3002HCC\u9810\u5f8c\u5dee\uff0c\u4e3b\u8981\u539f\u56e0\u662fHCC\u51fa\u73fe\u6642\u591a\u8a3a\u65b7\u70ba\u665a\u671f\u816b\u7624\uff0c\u800c\u5c0d\u65bc\u665a\u671fHCC\u800c\u8a00\uff0c\u6211\u5011\u5c1a\u672a\u767c\u73fe\u6709\u6548\u7684\u6cbb\u7642\u624b\u6bb5\u4f86\u5e6b\u52a9\u60a3\u8005\u5be6\u73fe\u9577\u671f\u751f\u5b58 <span>[3]<\/span>\u3002<\/p>\n<p>\u95dc\u65bc\u57fa\u77f3\u85e5\u696d<\/p>\n<p>\u57fa\u77f3\u85e5\u696d\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc: 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href=\"http:\/\/www.cstonepharma.com\/\" target=\"_blank\" rel=\"noopener\"><span>www.cstonepharma.com<\/span><\/a><\/span>\u3002<\/p>\n<p>\u95dc\u65bc\u4e09\u751f\u88fd\u85e5<\/p>\n<p>\u4e09\u751f\u88fd\u85e5\u662f\u4e00\u5bb6\u96c6\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u70ba\u4e00\u9ad4\u7684\u751f\u7269\u88fd\u85e5\u9818\u8ecd\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u4ee5\u9ad8\u54c1\u8cea\u7684\u85e5\u54c1\u63d0\u9ad8\u60a3\u8005\u751f\u5b58\u8cea\u91cf\uff0c\u70ba\u4eba\u985e\u5065\u5eb7\u9020\u798f\u3002\u76ee\u524d\uff0c\u516c\u53f8\u64c1\u6709100\u4f59\u9805\u570b\u5bb6\u767c\u660e\u5c08\u5229\u6388\u6b0a\uff0c40\u4f59\u7a2e\u4e0a\u5e02\u7522\u54c1\uff0c\u8986\u84cb\u814e\u79d1\u3001\u816b\u7624\u79d1\u3001\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3001\u773c\u79d1\u53ca\u76ae\u819a\u79d1\u7b49\u591a\u7a2e\u6cbb\u7642\u9818\u57df\u3002\u516c\u53f8\u64c1\u6709\u6297\u9ad4\u85e5\u7269\u570b\u5bb6\u5de5\u7a0b\u7814\u7a76\u4e2d\u5fc3\u4ee5\u53ca\u751f\u7269\u85e5\u548c\u5316\u85e5\u96d9\u5e73\u81fa\u76844\u5927\u7814\u767c\u4e2d\u5fc3\uff0c\u5171\u670930\u7a2e\u5728\u7814\u7522\u54c1\uff0c\u5176\u4e2d25\u7a2e\u70ba\u570b\u5bb6\u65b0\u85e5\uff0c\u4e26\u64c1\u6709\u7b26\u5408GMP\u6a19\u6e96\u76845\u5927\u751f\u7522\u57fa\u5730\u3002\u672a\u4f86\uff0c\u4e09\u751f\u88fd\u85e5\u5c07\u7e7c\u7e8c\u79c9\u6301\u300c\u73cd\u611b\u751f\u547d\u3001\u95dc\u8a3b\u751f\u5b58\u3001\u5275\u9020\u751f\u6d3b\u300d\u7684\u7406\u5ff5\uff0c\u5168\u529b\u6253\u9020\u5168\u7403\u9818\u5148\u7684\u4e2d\u570b\u751f\u7269\u88fd\u85e5\u4f01\u696d\u3002\u8acb\u8a2a\u554f <span><a href=\"http:\/\/www.3sbio.com\/\">www.3sbio.com<\/a><\/span> \u7372\u53d6\u66f4\u591a\u4fe1\u606f\u3002<\/p>\n<p>\u524d\u77bb\u6027\u8072\u660e<\/p>\n<p>\u672c\u6587\u6240\u4f5c\u51fa\u7684\u524d\u77bb\u6027\u9673\u8ff0\u50c5\u8207\u672c\u6587\u4f5c\u51fa\u8a72\u9673\u8ff0\u7576\u65e5\u7684\u4e8b\u4ef6\u6216\u8cc7\u6599\u6709\u95dc\u3002\u9664\u6cd5\u5f8b\u898f\u5b9a\u5916\uff0c\u65bc\u4f5c\u51fa\u524d\u77bb\u6027\u9673\u8ff0\u7576\u65e5\u4e4b\u5f8c\uff0c\u7121\u8ad6\u662f\u5426\u51fa\u73fe\u65b0\u8cc7\u6599\u3001\u672a\u4f86\u4e8b\u4ef6\u6216\u5176\u4ed6\u60c5\u6cc1\uff0c\u6211\u5011\u4e26\u7121\u8cac\u4efb\u66f4\u65b0\u6216\u516c\u958b\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9673\u8ff0\u53ca\u9810\u6599\u4e4b\u5916\u7684\u4e8b\u4ef6\u3002\u8acb\u7d30\u95b1\u672c\u6587\uff0c\u4e26\u7406\u89e3\u6211\u5011\u7684\u5be6\u969b\u672a\u4f86\u696d\u7e3e\u6216\u8868\u73fe\u53ef\u80fd\u8207\u9810\u671f\u6709\u91cd\u5927\u5dee\u7570\u3002\u672c\u6587\u5167\u6240\u6709\u9673\u8ff0\u4e43\u672c\u6587\u7ae0\u520a\u767c\u65e5\u671f\u4f5c\u51fa\uff0c\u53ef\u80fd\u56e0\u672a\u4f86\u767c\u5c55\u800c\u51fa\u73fe\u8b8a\u52d5\u3002<\/p>\n<div>\n<p class=\"prnml4\"><span class=\"prnews_span\">[1] Llovet JM et al, Nat Rev Clin Oncol. 2022 Mar;19(3):151-172. Immunotherapies for hepatocellular carcinoma.<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">[2] Llovet JM et al, Nat Rev Dis Primers. 2021 Jan 21;7(1):6. Hepatocellular carcinoma.<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">[3] Ahn JC et al, Hepatology. 2021 Jan;73(1):422-436. Detection of Circulating Tumor Cells and Their Implications as a Biomarker for Diagnosis, Prognostication, and Therapeutic Monitoring in Hepatocellular Carcinoma.<\/span><\/p>\n<p>     <\/p>\n<\/div>\n<p>\u00a0<\/p>","protected":false},"excerpt":{"rendered":"<p>\u57fa\u77f3\u85e5\u696d\u6388\u4e88\u4e09\u751f\u88fd\u85e5\u5728\u4e2d\u570b\u5927\u9678\u5730\u5340\u958b\u767c\u3001\u8a3b\u518a\u3001\u751f\u7522\u548c\u5546\u696d\u5316\u6297PD-1\u55ae\u6297nofazinlimab\u7684\u7368\u5bb6\u8a31\u53ef\u6b0a\u76ca\u3002\u57fa\u77f3\u85e5\u696d\u5c07\u4fdd\u7559nofazinlimab\u5728\u4e2d\u570b\u5927\u9678\u4ee5\u5916\u5730\u5340\u7684\u6b0a\u5229\u3002 \u57fa\u77f3\u85e5\u696d\u8207\u4e09\u751f\u88fd\u85e5\u5f37\u5f37\u806f\u5408\uff0c\u767c\u63ee\u5404\u81ea\u7814\u767c\u3001\u751f\u7522\u53ca\u5546\u696d\u5316\u7684\u512a\u52e2\uff0c\u52a0\u901fnofazinlimab\u7684\u81e8\u5e8a\u958b\u767c\u548c\u5546\u696d\u5316\u9032\u7a0b\uff0c\u4ee5\u671f\u60e0\u53ca\u66f4\u591a\u4e2d\u570b\u60a3\u8005\u3002 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Cancer\u300b\u65bc2023\u5e749\u6708\u767c\u8868\u4e86nofazinlimab\u5df2\u5b8c\u6210\u7684\u9996\u6b21\u4eba\u9ad4\u8a66\u9a57\uff08CS1003-101\uff09\u6578\u64da\uff0c\u7814\u7a76\u8868\u660enofazinlimab\u55ae\u85e5\u6cbb\u7642\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u826f\u597d\uff0c\u672a\u89c0\u5bdf\u5230\u5291\u91cf\u9650\u88fd\u6027\u6bd2\u6027\uff08DLT\uff09\uff0c\u4e26\u5728\u591a\u500b\u7624\u7a2e\u4e2d\u89c0\u5bdf\u5230\u521d\u6b65\u6297\u816b\u7624\u6d3b\u6027\u3002 \u8607\u5dde2023\u5e7411\u67081\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; 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Cancer\u300b\u3002\u6578\u64da\u8868\u660e\uff0cnofazinlimab\u55ae\u85e5\u6cbb\u7642\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u826f\u597d\uff0c\u672a\u89c0\u5bdf\u5230\u5291\u91cf\u9650\u88fd\u6027\u6bd2\u6027\uff08DLT\uff09\uff0c\u4e26\u5728\u591a\u500b\u7624\u7a2e\u4e2d\u89c0\u5bdf\u5230\u521d\u6b65\u6297\u816b\u7624\u6d3b\u6027\u3002\u6b64\u5916\uff0cnofazinlimab\u806f\u5408\u4f96\u4f10\u66ff\u5c3c\u4e00\u7dda\u6cbb\u7642\u4e0d\u53ef\u5207\u9664\u7684\u4e2d\u570b\u665a\u671f\u809d\u7d30\u80de\u764c\u60a3\u8005\u7684Ib\u671f\u7814\u7a76\uff08CS1003-102-1b)\u6578\u64da\u4e5f\u66fe\u57282022\u5e74\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\u4e0a\u516c\u5e03\u3002\u6578\u64da\u986f\u793a\uff0cnofazinlimab\u806f\u5408\u4f96\u4f10\u66ff\u5c3c\u4e00\u7dda\u6cbb\u7642\u4e0d\u53ef\u5207\u9664\u665a\u671f\u809d\u7d30\u80de\u764c\u60a3\u8005\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u9054\u523045%\uff1b\u4e2d\u4f4d\u6301\u7e8c\u7de9\u89e3\u6642\u9593\uff08DoR\uff09\u81f3\u6578\u64da\u622a\u6b62\u6642\u4ecd\u672a\u9054\u5230\uff0c\u7bc4\u570d\u70ba4.2\u81f318.7+\u500b\u6708\uff1b\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u70ba10.4\u500b\u6708\uff1b\u5b89\u5168\u6027\u8010\u53d7\u826f\u597d\u3002 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www.3sbio.com \u7372\u53d6\u66f4\u591a\u4fe1\u606f\u3002 \u524d\u77bb\u6027\u8072\u660e \u672c\u6587\u6240\u4f5c\u51fa\u7684\u524d\u77bb\u6027\u9673\u8ff0\u50c5\u8207\u672c\u6587\u4f5c\u51fa\u8a72\u9673\u8ff0\u7576\u65e5\u7684\u4e8b\u4ef6\u6216\u8cc7\u6599\u6709\u95dc\u3002\u9664\u6cd5\u5f8b\u898f\u5b9a\u5916\uff0c\u65bc\u4f5c\u51fa\u524d\u77bb\u6027\u9673\u8ff0\u7576\u65e5\u4e4b\u5f8c\uff0c\u7121\u8ad6\u662f\u5426\u51fa\u73fe\u65b0\u8cc7\u6599\u3001\u672a\u4f86\u4e8b\u4ef6\u6216\u5176\u4ed6\u60c5\u6cc1\uff0c\u6211\u5011\u4e26\u7121\u8cac\u4efb\u66f4\u65b0\u6216\u516c\u958b\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9673\u8ff0\u53ca\u9810\u6599\u4e4b\u5916\u7684\u4e8b\u4ef6\u3002\u8acb\u7d30\u95b1\u672c\u6587\uff0c\u4e26\u7406\u89e3\u6211\u5011\u7684\u5be6\u969b\u672a\u4f86\u696d\u7e3e\u6216\u8868\u73fe\u53ef\u80fd\u8207\u9810\u671f\u6709\u91cd\u5927\u5dee\u7570\u3002\u672c\u6587\u5167\u6240\u6709\u9673\u8ff0\u4e43\u672c\u6587\u7ae0\u520a\u767c\u65e5\u671f\u4f5c\u51fa\uff0c\u53ef\u80fd\u56e0\u672a\u4f86\u767c\u5c55\u800c\u51fa\u73fe\u8b8a\u52d5\u3002 [1] Llovet JM et al, Nat Rev Clin Oncol. 2022 Mar;19(3):151-172. Immunotherapies for hepatocellular carcinoma. [2] Llovet JM et al, Nat Rev Dis Primers. 2021 Jan 21;7(1):6. Hepatocellular carcinoma. [3] Ahn JC et al, Hepatology. 2021 Jan;73(1):422-436. Detection of Circulating Tumor Cells and Their Implications as a Biomarker for Diagnosis, Prognostication, and Therapeutic Monitoring in Hepatocellular Carcinoma. \u00a0<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_generate-full-width-content":"","spay_email":"","footnotes":""},"categories":[1],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u57fa\u77f3\u85e5\u696d\u8207\u4e09\u751f\u88fd\u85e5\u9054\u6210Nofazinlimab\uff08\u6297PD-1\u55ae\u6297\uff09\u5728\u4e2d\u570b\u5927\u9678\u5730\u5340\u6230\u7565\u5408\u4f5c\u548c\u7368\u5bb6\u8a31\u53ef\u5354\u8b70 - \u9999\u6e2f\u7279\u8a31\u7d93\u71df<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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Immunotherapies for hepatocellular carcinoma. [2] Llovet JM et al, Nat Rev Dis Primers. 2021 Jan 21;7(1):6. Hepatocellular carcinoma. [3] Ahn JC et al, Hepatology. 2021 Jan;73(1):422-436. 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www.3sbio.com \u7372\u53d6\u66f4\u591a\u4fe1\u606f\u3002 \u524d\u77bb\u6027\u8072\u660e \u672c\u6587\u6240\u4f5c\u51fa\u7684\u524d\u77bb\u6027\u9673\u8ff0\u50c5\u8207\u672c\u6587\u4f5c\u51fa\u8a72\u9673\u8ff0\u7576\u65e5\u7684\u4e8b\u4ef6\u6216\u8cc7\u6599\u6709\u95dc\u3002\u9664\u6cd5\u5f8b\u898f\u5b9a\u5916\uff0c\u65bc\u4f5c\u51fa\u524d\u77bb\u6027\u9673\u8ff0\u7576\u65e5\u4e4b\u5f8c\uff0c\u7121\u8ad6\u662f\u5426\u51fa\u73fe\u65b0\u8cc7\u6599\u3001\u672a\u4f86\u4e8b\u4ef6\u6216\u5176\u4ed6\u60c5\u6cc1\uff0c\u6211\u5011\u4e26\u7121\u8cac\u4efb\u66f4\u65b0\u6216\u516c\u958b\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9673\u8ff0\u53ca\u9810\u6599\u4e4b\u5916\u7684\u4e8b\u4ef6\u3002\u8acb\u7d30\u95b1\u672c\u6587\uff0c\u4e26\u7406\u89e3\u6211\u5011\u7684\u5be6\u969b\u672a\u4f86\u696d\u7e3e\u6216\u8868\u73fe\u53ef\u80fd\u8207\u9810\u671f\u6709\u91cd\u5927\u5dee\u7570\u3002\u672c\u6587\u5167\u6240\u6709\u9673\u8ff0\u4e43\u672c\u6587\u7ae0\u520a\u767c\u65e5\u671f\u4f5c\u51fa\uff0c\u53ef\u80fd\u56e0\u672a\u4f86\u767c\u5c55\u800c\u51fa\u73fe\u8b8a\u52d5\u3002 [1] Llovet JM et al, Nat Rev Clin Oncol. 2022 Mar;19(3):151-172. Immunotherapies for hepatocellular carcinoma. [2] Llovet JM et al, Nat Rev Dis Primers. 2021 Jan 21;7(1):6. Hepatocellular carcinoma. [3] Ahn JC et al, Hepatology. 2021 Jan;73(1):422-436. 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