{"id":15395,"date":"2023-10-23T13:45:00","date_gmt":"2023-10-23T05:45:00","guid":{"rendered":"https:\/\/www.franchise.com.hk\/%e5%89%b5%e5%8b%9d%e9%9b%86%e5%9c%98%e6%96%bcesmo-2023%e5%b9%b4%e6%9c%83%e5%85%ac%e4%bd%88osemitamab-tst001-%e8%81%af%e5%90%88capox%e4%b8%80%e7%b7%9a%e6%b2%bb%e7%99%82%e8%83%83%e6%88%96%e8%83%83\/15395"},"modified":"2023-10-23T13:45:00","modified_gmt":"2023-10-23T05:45:00","slug":"%e5%89%b5%e5%8b%9d%e9%9b%86%e5%9c%98%e6%96%bcesmo-2023%e5%b9%b4%e6%9c%83%e5%85%ac%e4%bd%88osemitamab-tst001-%e8%81%af%e5%90%88capox%e4%b8%80%e7%b7%9a%e6%b2%bb%e7%99%82%e8%83%83%e6%88%96%e8%83%83","status":"publish","type":"post","link":"https:\/\/www.franchise.com.hk\/en\/%e5%89%b5%e5%8b%9d%e9%9b%86%e5%9c%98%e6%96%bcesmo-2023%e5%b9%b4%e6%9c%83%e5%85%ac%e4%bd%88osemitamab-tst001-%e8%81%af%e5%90%88capox%e4%b8%80%e7%b7%9a%e6%b2%bb%e7%99%82%e8%83%83%e6%88%96%e8%83%83\/15395","title":{"rendered":"\u5275\u52dd\u96c6\u5718\u65bcESMO 2023\u5e74\u6703\u516c\u4f48Osemitamab (TST001) \u806f\u5408CAPOX\u4e00\u7dda\u6cbb\u7642\u80c3\u6216\u80c3\u98df\u7ba1\u7d50\u5408\u90e8\u817a\u764c\u7684\u66f4\u65b0\u7642\u6548\u6578\u64da"},"content":{"rendered":"

\u6700\u65b0\u6578\u64da\u63ed\u793a\uff1a\u64f4\u5c55\u968e\u6bb5\u6240\u6709\u63a5\u53d7\u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c55%\u78ba\u8a8d\u7de9\u89e3\u7387\uff0c\u4e2d\u4f4d\u61c9\u9054\u6301\u7e8c\u6642\u9593(DoR)\u53ca\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f(PFS)\u8d85\u904e12\u500b\u6708\u3002<\/p>\n

\u7f8e\u570b\u65b0\u6fa4\u897f\u5dde\u666e\u6797\u65af\u9813\u548c\u4e2d\u570b\u8607\u5dde<\/span>2023\u5e7410\u670823\u65e5<\/span> \/\u7f8e\u901a\u793e\/ —\u00a0\u5275\u52dd\u96c6\u5718(06628.HK)\uff0c\u4e00\u5bb6\u5177\u5099\u751f\u7269\u85e5\u54c1\u767c\u73fe\u3001\u7814\u767c\u3001\u5de5\u85dd\u958b\u767c\u548c\u751f\u7522\u5168\u6d41\u7a0b\u6574\u5408\u80fd\u529b\u7684\u81e8\u5e8a\u968e\u6bb5\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u5ba3\u4f48\u5df2\u65bc\u897f\u73ed\u7259\u99ac\u5fb7\u91cc\u8209\u8fa6\u7684ESMO 2023\u5e74\u6703\u516c\u4f48TranStar102\u64f4\u5c55\u968a\u5217\u7814\u7a76\u4e2dOsemitamab (TST001)\u806f\u5408\u5361\u57f9\u4ed6\u6ff1\u548c\u5967\u6c99\u5229\u9251(CAPOX)\u5316\u7642\u4e00\u7dda\u6cbb\u7642\u665a\u671f\u80c3\u6216\u80c3\u98df\u7ba1\u7d50\u5408\u90e8\u817a\u764c(G\/GEJ)\u7684\u66f4\u65b0\u7642\u6548\u6578\u64da\u3002\u76f8\u8f03\u65bc\u5148\u524d\u516c\u4f48\u7684\u901a\u904e\u7528\u65bc\u7be9\u9078\u60a3\u8005\u7684LDT\u514d\u75ab\u7d44\u5316\u65b9\u6cd5\u7be9\u9078CLDN18.2\u8868\u9054\u226510%\u7684\u816b\u7624\u7d30\u80de\u7684\u819c\u67d3\u8272\u5f37\u5ea6\u22651+\u7684\u60a3\u8005\u7684\u6578\u64da\uff0c\u66f4\u65b0\u6578\u64da\u9032\u4e00\u6b65\u5c55\u73fe\u51fa\u4ee4\u4eba\u9f13\u821e\u7684\u7642\u6548\u3002\u4ea6\u516c\u4f48\u5169\u9805\u7246\u5831\uff1a\u4e00\u9805\u662f\u95dc\u65bc\u652f\u6301Osemitamab (TST001)\u3001nivolumab\u548c\u5316\u7642\u7684\u4e09\u806f\u7642\u6cd5\u512a\u65bcOsemitamab (TST001)\u548c\u5316\u7642\uff08\u5305\u62ecPD-L1\u9670\u6027\u816b\u7624\uff09\u7684\u81e8\u5e8a\u524d\u6578\u64da\uff1b\u53e6\u4e00\u9805\u5247\u8a73\u8ff0\u4e86\u652f\u6301\u63a8\u85a6III\u671f\u5291\u91cf\u7684\u81e8\u5e8a\u85e5\u7406\u5b78\u63a2\u7d22\u3002<\/p>\n

\u300c\u8a72\u7b49\u6700\u65b0\u6578\u64da\u96c6\u9032\u4e00\u6b65\u8b49\u5be6\u4e86Osemitamab (TST001)\u806f\u5408CAPOX\u5316\u7642\u4f5c\u70ba\u5305\u62ecCLDN18.2\u8868\u9054\u6c34\u5e73\u8f03\u4f4e\u7684\u816b\u7624\u5728\u5167\u7684\u665a\u671f\u80c3\u6216\u80c3\u98df\u7ba1\u7d50\u5408\u90e8\u817a\u764c\u4e00\u7dda\u6cbb\u7642\u7684\u7642\u6548\uff0c\u4e26\u70ba\u5728\u8868\u9054\u4e0d\u540c\u6c34\u5e73PD-L1 CPS\u7684\u816b\u7624\u75c5\u4eba\u4e2d\u63a2\u7d22Osemitamab (TST001)\u8207nivolumab\u548c\u5316\u7642\u4e09\u806f\u7642\u6cd5\u63d0\u4f9b\u57fa\u672c\u539f\u7406\u3002\u300d\u5275\u52dd\u96c6\u5718\u5168\u7403\u85e5\u7269\u958b\u767c\u57f7\u884c\u526f\u7e3d\u88c1\uff0c\u9996\u5e2d\u91ab\u5b78\u5b98Caroline Germa\u535a\u58eb\u8868\u793a\uff0c\u300c\u6211\u5011\u5c0d\u7642\u6548\u7d50\u679c\u4ee5\u53ca\u8fd1\u671fFDA\u6279\u51c6\u516c\u53f8\u958b\u5c55\u5168\u7403III \u671f\u81e8\u5e8a\u8a66\u9a57\u611f\u5230\u975e\u5e38\u9f13\u821e\uff0c\u9019\u8868\u660eOsemitamab (TST001)\u6709\u671b\u91cd\u65b0\u5b9a\u7fa9CLDN18.2\u967d\u6027\u3001HER2\u9670\u6027\u80c3\u6216\u80c3\u98df\u7ba1\u7d50\u5408\u90e8\u817a\u764c\u60a3\u8005\u7684\u73fe\u884c\u6cbb\u7642\u6a19\u6e96\u3002\u300d<\/p>\n

\u8a66\u9a57\u8a2d\u8a08<\/p>\n

Transtar102\u7814\u7a76C\u968a\u5217( NCT04495296) \u65e8\u5728\u63a2\u7d22Osemitamab (TST001) \u806f\u5408CAPOX\u4e00\u7dda\u6cbb\u7642\u665a\u671f\u80c3\u6216\u80c3\u98df\u7ba1\u7d50\u5408\u90e8\u817a\u764c(G\/GEJ)\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u8a72\u7814\u7a76\u5171\u670949\u4f8b\u60a3\u8005\u5165\u7d44\u4e26\u63a5\u53d7\u7642\u6548\u64f4\u5c55\u968a\u52176mg\/kg Q3W\u7684Osemitamab (TST001)\u806f\u5408CAPOX\u6cbb\u7642\u3002<\/p>\n

49 \u4f8b\u5165\u7d44\u60a3\u8005\u4e2d\uff0c41 \u4f8b\u60a3\u8005\u7684\u816b\u7624\u5448CLDN18.2 \u967d\u6027\u8868\u9054\uff0c\u53e6\u59168 \u4f8b\u60a3\u8005\u672a\u9032\u884c\u751f\u7269\u6a19\u8a8c\u7269\u6aa2\u6e2c\u3002\u4f7f\u7528\u7d93\u4e2d\u5fc3\u5be6\u9a57\u5ba4\u9a57\u8b49\u768414G11 LDT\u514d\u75ab\u7d44\u5316\u65b9\u6cd5\u9a57\u8b49CLDN18.2\u8868\u9054\uff0cCLDN18.2 \u967d\u6027\u816b\u7624\u5373\u7528LDT\u65b9\u6cd5\u226510%\u7684\u816b\u7624\u7d30\u80de\u7684\u819c\u67d3\u8272\u5f37\u5ea6\u22651+\uff0c\u7d04\u5360\u6240\u6709\u80c3\u6216\u80c3\u98df\u7ba1\u9023\u63a5\u90e8\u764c\u75c7\u60a3\u8005\u768455%\u3002<\/p>\n

\u9f13\u821e\u4eba\u5fc3\u4e14\u6301\u4e45\u7684\u4e2d\u4f4d\u7de9\u89e3\u6301\u7e8c\u6642\u9593\u548c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\u6578\u64da<\/p>\n

\u622a\u81f3\u5831\u544a\u65e5\u671f\uff0c49\u4f8b\u60a3\u8005\u7684\u4e2d\u4f4d\u96a8\u8a2a\u6642\u9593\u70ba11.3\u500b\u6708\uff0c\u6700\u9577\u6cbb\u7642\u6301\u7e8c\u6642\u9593\u8d85\u904e1.5\u5e74\u3002\u5728\u901949\u4f8b\u60a3\u8005\u4e2d\uff0c42\u4f8b\u60a3\u8005\u5728\u57fa\u7dda\u548c\u81f3\u5c11\u4e00\u6b21\u57fa\u7dda\u5f8c\u816b\u7624\u8a55\u4f30\u4e2d\u5177\u6709\u53ef\u6e2c\u91cf\u75c5\u7076\uff0c\u5176\u4e2d28\u4f8b\u60a3\u8005\u51fa\u73fe\u90e8\u5206\u7de9\u89e3\uff0c23\u4f8b\u60a3\u8005\u78ba\u8a8d\u7de9\u89e3\uff0854.8%\uff0c23\/42\uff09\uff0c\u4e2d\u4f4d\u7de9\u89e3\u6301\u7e8c\u6642\u9593(DoR)\u70ba12.7 \u500b\u6708\u300249\u4f8b\u60a3\u8005\u4e2d\u670920\u4f8b\u51fa\u73fe\u75be\u75c5\u9032\u5c55\u6216\u6b7b\u4ea1\uff0c\u4f30\u8a08\u7684\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f(PFS)\u70ba14\u500b\u6708\u3002\u7531\u65bc\u4e8b\u4ef6\u6578\u91cf\u6709\u9650\uff0c\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f(mOS)\u5c1a\u672a\u9054\u5230\uff0cC\u968a\u5217\uff0864\u4f8b\u60a3\u8005\uff0c\u6240\u6709\u5291\u91cf\uff09\u768412\u500b\u6708\u751f\u5b58\u7387\u70ba88.9%\uff0895% CI\uff1a74.2, 95.4\uff09\u3002\u9019\u9032\u4e00\u6b65\u5370\u8b49\u4e86\u672c\u516c\u53f8\u8fd1\u671f\u7372FDA\u6279\u51c6\u7684III\u671f\u8a66\u9a57\u7b56\u7565\u7684\u53ef\u884c\u6027\uff0c\u5373\u5c07Osemitamab (TST001)\u8207nivolumab\u548c\u5316\u7642\u806f\u7528\uff0c\u4f5c\u70baCLDN18.2\u967d\u6027\u80c3\u6216\u80c3\u98df\u7ba1\u7d50\u5408\u90e8\u817a\u764c\u7684\u4e00\u7dda\u6cbb\u7642\u65b9\u6848\u3002<\/p>\n

\u512a\u7570\u4e14\u53ef\u63a7\u7684\u5b89\u5168\u6027<\/p>\n

49\u4f8b\u60a3\u8005\u7684\u5b89\u5168\u6027\u7279\u5fb5\u4e3b\u8981\u8868\u73fe\u70ba\u53ef\u63a7\u7684\u9776\u5411\u975e\u816b\u7624\u6548\u61c9\uff0c\u5305\u62ec\u5641\u5fc3\u3001\u4f4e\u767d\u86cb\u767d\u8840\u75c7\u548c\u5614\u5410\uff0c\u5927\u90e8\u5206\u70ba1\u7d1a\u62162\u7d1a\uff0c\u4e26\u767c\u751f\u5728\u524d2\u500b\u9031\u671f\u3002<\/p>\n

\u6b64\u5916\uff0c\u5728\u5927\u6703\u4e0a\u5c55\u793a\u7684\u81e8\u5e8a\u524d\u6578\u64da(#1560P) \u986f\u793a\uff0cOsemitamab (TST001) \u53ef\u986f\u8457\u4e0a\u8abf\u80c3\u764c\u7d30\u80de\u7684PD-L1 \u8868\u9054\uff0c\u4e26\u4fc3\u9032\u816b\u7624\u6d78\u6f64\u6dcb\u5df4\u7d30\u80de(TIL) \u5411\u816b\u7624\u5167\u6d78\u6f64\u3002\u5728CLDN18.2 \u967d\u6027\/PD-L1 \u9670\u6027\u7684\u80c3\u764c\u4eba\u6e90\u816b\u7624\u7570\u7a2e\u79fb\u690d(PDX)\u6a21\u578b\u4e2d\uff0c\u5305\u62ec\u6297CLDN18.2\u6297\u9ad4Osemitamab\u00a0\u00a0 (TST001)\u8207PD1\u6291\u5236\u5291nivolumab\u548c\u5316\u7642\u806f\u7528\uff0c\u5c55\u73fe\u51fa\u986f\u8457\u7684\u5354\u540c\u6548\u61c9\u3002\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0c\u901a\u904e\u63a5\u53d7Osemitamab (TST001)\u806f\u5408nivolumab\u548c\u5316\u7642\u3001Osemitamab (TST001)\u806f\u5408\u5316\u7642\u3001nivolumab\u806f\u5408\u5316\u7642\u6216\u50c5\u5316\u7642\u7684\u6cbb\u7642\uff0c \u5206\u5225\u67095\/8\u30012\/8\u30010\/8\u30010\/8\u53ea\u5c0f\u9f20\u9054\u5230\u4e86\u816b\u7624\u6d88\u9664\u3002<\/p>\n

\u5728\u5c0d\u63a5\u53d7Osemitamab (TST001)\u806f\u5408CAPOX\u4e00\u7dda\u6cbb\u7642\u80c3\u6216\u80c3\u98df\u7ba1\u7d50\u5408\u90e8\u817a\u764c\u768458 \u4f8b\u60a3\u8005\u7684\u6578\u64da\u9032\u884c\u7684ER\u5206\u6790\u4e2d\uff0c\u8f03\u9577\u7684PFS\/DoR\u53ca\u66f4\u6301\u4e45\u7684ORR\u8da8\u52e2\u8207\u8f03\u9ad8\u7684Osemitamab (TST001)\u66b4\u9732\u6709\u95dc\uff0c\u4e14\u82076mg\/kg Q3W\u6240\u9054\u81f4\u7684\u66b4\u9732\u7bc4\u570d\u4e00\u81f4\u3002\u5b89\u5168\u6027ER\u5206\u6790\u986f\u793a\uff0c\u7576\u5291\u91cf\u5f9e3mg\/kg Q3W\u589e\u52a0\u81f36mg\/kg Q3W\u6642\uff0c\u81e8\u5e8a\u98a8\u96aa\u4e26\u7121\u986f\u8457\u589e\u52a0\u3002Osemitamab (TST001)\u7684\u521d\u6b65\u7642\u6548\u3001\u5b89\u5168\u6027\u53caPK\/PD\u6578\u64da\u986f\u793a\u4e86\u512a\u7570\u7684\u6536\u76ca\u98a8\u96aa\u7279\u5fb5\uff0c\u4e26\u652f\u6301\u672a\u4f86\u4ee56mg\/kg Q3W\u62164mg\/kg Q2W\u5291\u91cf\u9032\u884c\u63a2\u7d22\u3002<\/p>\n

\u95dc\u65bcOsemitamab (TST001)<\/p>\n

Osemitamab (TST001) \u662f\u4e00\u7a2e\u9ad8\u89aa\u548c\u529b\u7684\u9776\u5411CLDN18.2\u7684\u4eba\u6e90\u5316\u55ae\u514b\u9686\u6297\u9ad4\uff0c\u5177\u6709\u589e\u5f37\u7684\u6297\u9ad4\u4f9d\u8cf4\u6027\u7d30\u80de\u6bd2\u6027\uff08ADCC\uff09\uff0c\u5728\u7570\u7a2e\u79fb\u690d\u8a66\u9a57\u4e2d\u986f\u793a\u51fa\u5f37\u5927\u7684\u6297\u816b\u7624\u6d3b\u6027\u3002Osemitamab (TST001) \u662f\u5168\u7403\u7bc4\u570d\u5167\u958b\u767c\u7684\u7b2c\u4e8c\u500b\u6700\u5148\u9032\u7684CLDN18.2\u9776\u5411\u6297\u9ad4\u85e5\u7269\uff0c\u7531\u672c\u516c\u53f8\u901a\u904e\u5176\u514d\u75ab\u8010\u53d7\u7a81\u7834(IMTB)\u6280\u8853\u5e73\u53f0\u958b\u767c\u3002Osemitamab (TST001) \u901a\u904eADCC\u6a5f\u5236\u6bba\u6b7b\u8868\u9054CLDN18.2\u7684\u816b\u7624\u7d30\u80de\u3002\u5229\u7528\u5148\u9032\u7684\u751f\u7269\u52a0\u5de5\u6280\u8853\uff0cOsemitamab (TST001) \u7684\u5dd6\u85fb\u7cd6\u542b\u91cf\u5728\u751f\u7522\u904e\u7a0b\u4e2d\u5927\u5927\u964d\u4f4e\uff0c\u9032\u4e00\u6b65\u589e\u5f37\u4e86Osemitamab (TST001) \u7684NK\u7d30\u80de\u4ecb\u5c0e\u7684ADCC\u6d3b\u6027\u3002\u4e2d\u570b\u548c\u7f8e\u570b\u5747\u4e00\u76f4\u5728\u9032\u884cOsemitamab (TST001) \u7684\u81e8\u5e8a\u8a66\u9a57(NCT05190575\u3001NCT04396821\u3001NCT04495296\u3001NCT05608785 \/ CTR20201281)\u3002\u7f8e\u570b\u98df\u54c1\u548c\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40(FDA)\u5df2\u6388\u4e88Osemitamab (TST001) \u7528\u65bc\u6cbb\u7642\u80c3\u764c\u6216\u80c3\u98df\u7ba1\u7d50\u5408\u90e8\u817a\u764c\u548c\u80f0\u817a\u764c\u60a3\u8005\u7684\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\u3002<\/p>\n

\u95dc\u65bc\u5275\u52dd\u96c6\u5718<\/p>\n

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\u524d\u77bb\u6027\u8072\u660e<\/p>\n

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Transcenta\u548cOsemitamab\u662fTranscenta Holding Limited\u7684\u5546\u6a19\u3002\u6240\u6709\u5176\u4ed6\u54c1\u724c\u548c\u7522\u54c1\u540d\u7a31\u53ef\u80fd\u662f\u5176\u5404\u81ea\u6240\u6709\u8005\u7684\u5546\u6a19\u548c\/\u6216\u8a3b\u518a\u5546\u6a19\u3002<\/p>\n

\u00a0<\/p>","protected":false},"excerpt":{"rendered":"

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Transcenta\u548cOsemitamab\u662fTranscenta Holding Limited\u7684\u5546\u6a19\u3002\u6240\u6709\u5176\u4ed6\u54c1\u724c\u548c\u7522\u54c1\u540d\u7a31\u53ef\u80fd\u662f\u5176\u5404\u81ea\u6240\u6709\u8005\u7684\u5546\u6a19\u548c\/\u6216\u8a3b\u518a\u5546\u6a19\u3002 \u00a0<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_generate-full-width-content":"","spay_email":"","footnotes":""},"categories":[1],"tags":[],"yoast_head":"\n\u5275\u52dd\u96c6\u5718\u65bcESMO 2023\u5e74\u6703\u516c\u4f48Osemitamab (TST001) \u806f\u5408CAPOX\u4e00\u7dda\u6cbb\u7642\u80c3\u6216\u80c3\u98df\u7ba1\u7d50\u5408\u90e8\u817a\u764c\u7684\u66f4\u65b0\u7642\u6548\u6578\u64da - \u9999\u6e2f\u7279\u8a31\u7d93\u71df<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.franchise.com.hk\/en\/%e5%89%b5%e5%8b%9d%e9%9b%86%e5%9c%98%e6%96%bcesmo-2023%e5%b9%b4%e6%9c%83%e5%85%ac%e4%bd%88osemitamab-tst001-%e8%81%af%e5%90%88capox%e4%b8%80%e7%b7%9a%e6%b2%bb%e7%99%82%e8%83%83%e6%88%96%e8%83%83\/15395\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u5275\u52dd\u96c6\u5718\u65bcESMO 2023\u5e74\u6703\u516c\u4f48Osemitamab (TST001) \u806f\u5408CAPOX\u4e00\u7dda\u6cbb\u7642\u80c3\u6216\u80c3\u98df\u7ba1\u7d50\u5408\u90e8\u817a\u764c\u7684\u66f4\u65b0\u7642\u6548\u6578\u64da - \u9999\u6e2f\u7279\u8a31\u7d93\u71df\" \/>\n<meta property=\"og:description\" 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(TST001)\u548c\u5316\u7642\uff08\u5305\u62ecPD-L1\u9670\u6027\u816b\u7624\uff09\u7684\u81e8\u5e8a\u524d\u6578\u64da\uff1b\u53e6\u4e00\u9805\u5247\u8a73\u8ff0\u4e86\u652f\u6301\u63a8\u85a6III\u671f\u5291\u91cf\u7684\u81e8\u5e8a\u85e5\u7406\u5b78\u63a2\u7d22\u3002 \u300c\u8a72\u7b49\u6700\u65b0\u6578\u64da\u96c6\u9032\u4e00\u6b65\u8b49\u5be6\u4e86Osemitamab (TST001)\u806f\u5408CAPOX\u5316\u7642\u4f5c\u70ba\u5305\u62ecCLDN18.2\u8868\u9054\u6c34\u5e73\u8f03\u4f4e\u7684\u816b\u7624\u5728\u5167\u7684\u665a\u671f\u80c3\u6216\u80c3\u98df\u7ba1\u7d50\u5408\u90e8\u817a\u764c\u4e00\u7dda\u6cbb\u7642\u7684\u7642\u6548\uff0c\u4e26\u70ba\u5728\u8868\u9054\u4e0d\u540c\u6c34\u5e73PD-L1 CPS\u7684\u816b\u7624\u75c5\u4eba\u4e2d\u63a2\u7d22Osemitamab (TST001)\u8207nivolumab\u548c\u5316\u7642\u4e09\u806f\u7642\u6cd5\u63d0\u4f9b\u57fa\u672c\u539f\u7406\u3002\u300d\u5275\u52dd\u96c6\u5718\u5168\u7403\u85e5\u7269\u958b\u767c\u57f7\u884c\u526f\u7e3d\u88c1\uff0c\u9996\u5e2d\u91ab\u5b78\u5b98Caroline Germa\u535a\u58eb\u8868\u793a\uff0c\u300c\u6211\u5011\u5c0d\u7642\u6548\u7d50\u679c\u4ee5\u53ca\u8fd1\u671fFDA\u6279\u51c6\u516c\u53f8\u958b\u5c55\u5168\u7403III \u671f\u81e8\u5e8a\u8a66\u9a57\u611f\u5230\u975e\u5e38\u9f13\u821e\uff0c\u9019\u8868\u660eOsemitamab (TST001)\u6709\u671b\u91cd\u65b0\u5b9a\u7fa9CLDN18.2\u967d\u6027\u3001HER2\u9670\u6027\u80c3\u6216\u80c3\u98df\u7ba1\u7d50\u5408\u90e8\u817a\u764c\u60a3\u8005\u7684\u73fe\u884c\u6cbb\u7642\u6a19\u6e96\u3002\u300d \u8a66\u9a57\u8a2d\u8a08 Transtar102\u7814\u7a76C\u968a\u5217( NCT04495296) \u65e8\u5728\u63a2\u7d22Osemitamab (TST001) \u806f\u5408CAPOX\u4e00\u7dda\u6cbb\u7642\u665a\u671f\u80c3\u6216\u80c3\u98df\u7ba1\u7d50\u5408\u90e8\u817a\u764c(G\/GEJ)\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u8a72\u7814\u7a76\u5171\u670949\u4f8b\u60a3\u8005\u5165\u7d44\u4e26\u63a5\u53d7\u7642\u6548\u64f4\u5c55\u968a\u52176mg\/kg Q3W\u7684Osemitamab (TST001)\u806f\u5408CAPOX\u6cbb\u7642\u3002 49 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49\u4f8b\u60a3\u8005\u7684\u5b89\u5168\u6027\u7279\u5fb5\u4e3b\u8981\u8868\u73fe\u70ba\u53ef\u63a7\u7684\u9776\u5411\u975e\u816b\u7624\u6548\u61c9\uff0c\u5305\u62ec\u5641\u5fc3\u3001\u4f4e\u767d\u86cb\u767d\u8840\u75c7\u548c\u5614\u5410\uff0c\u5927\u90e8\u5206\u70ba1\u7d1a\u62162\u7d1a\uff0c\u4e26\u767c\u751f\u5728\u524d2\u500b\u9031\u671f\u3002 \u6b64\u5916\uff0c\u5728\u5927\u6703\u4e0a\u5c55\u793a\u7684\u81e8\u5e8a\u524d\u6578\u64da(#1560P) \u986f\u793a\uff0cOsemitamab (TST001) \u53ef\u986f\u8457\u4e0a\u8abf\u80c3\u764c\u7d30\u80de\u7684PD-L1 \u8868\u9054\uff0c\u4e26\u4fc3\u9032\u816b\u7624\u6d78\u6f64\u6dcb\u5df4\u7d30\u80de(TIL) \u5411\u816b\u7624\u5167\u6d78\u6f64\u3002\u5728CLDN18.2 \u967d\u6027\/PD-L1 \u9670\u6027\u7684\u80c3\u764c\u4eba\u6e90\u816b\u7624\u7570\u7a2e\u79fb\u690d(PDX)\u6a21\u578b\u4e2d\uff0c\u5305\u62ec\u6297CLDN18.2\u6297\u9ad4Osemitamab\u00a0\u00a0 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