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\/>\n\u4e00\u4f8b\u78ba\u8a8d\u90e8\u5206\u7de9\u89e3\u4f86\u81ea\u4e00\u4f4d\u5bae\u9838\u764c\u60a3\u8005\uff0c\u8a72\u60a3\u8005\u5728\u65e2\u5f80\u5169\u7dda\u6cbb\u7642\uff08\u5305\u542b9\u500b\u9031\u671f\u7684\u5e15\u535a\u5229\u73e0\u55ae\u6297\u55ae\u4e00\u6cbb\u7642\uff09\u5f8c\u51fa\u73fe\u75be\u75c5\u9032\u5c55\uff0c\u7b26\u5408PD-1\u8010\u85e5\u6a19\u6e96\u3002     \u4e00\u4f4d\u982d\u9838\u90e8\u9c57\u72c0\u7d30\u80de\u764c\u60a3\u8005\u89c0\u5bdf\u5230\u78ba\u8a8d\u90e8\u5206\u7de9\u89e3\u4ee5\u53ca\u9776\u75c5\u7076\u5b8c\u5168\u840e\u7e2e\u3002\u60a3\u8005\u65e2\u5f80\u672a\u63a5\u53d7\u904e\u514d\u75ab\u6cbb\u7642\uff0cCPS\u8a55\u5206\u8f03\u4f4e\u3002<br \/>\n\u5728\u5291\u91cf\u905e\u589e\u8a66\u9a57\u968e\u6bb5\u63a5\u53d7\u5291\u91cf\u6c34\u5e73\u70ba10 mg\/kg\u4e14\u6bcf3\u5468\u7d66\u85e5\u7684ADG126\u8207\u6297PD-1\u806f\u5408\u6cbb\u7642\u7684\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c\u89c0\u5bdf\u523040%\u7684\u7e3d\u7de9\u89e3\u7387\uff084\/10\uff09\uff0c\u4ee5\u53ca10%\u76843\u7d1a\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\u6982\u7387\uff0c\u672a\u89c0\u5bdf\u52303\u7d1a\u4ee5\u4e0a\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\uff0c\u4e5f\u672a\u89c0\u5bdf\u5230\u5291\u91cf\u9650\u5236\u6027\u6bd2\u6027\u3002\u5728\u6bcf6\u546810 mg\/kg\u548c\u6bcf3\u54686 mg\/kg\u7684\u7d66\u85e5\u983b\u7387\u548c\u5291\u91cf\u4e0b\u540c\u6a23\u4e5f\u89c0\u5bdf\u5230\u4e86\u81e8\u5e8a\u7642\u6548\u3002    \u91dd\u5c0d\u7121\u809d\u8f49\u79fb\u7684\u5fae\u885b\u661f\u7a69\u5b9a\u578b\u665a\u671f\u7d50\u76f4\u8178\u764c\u7684\u5291\u91cf\u64f4\u5c55\u968a\u5217\u63a1\u7528\u4e86\u5169\u7d44\u7d66\u85e5\u65b9\u6848\uff1a\u5206\u5225\u662fADG126\uff0c10 mg\/kg\uff0c\u6bcf6\u5468\u7d66\u85e5\uff0810\u540d\u60a3\u8005\uff09\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6cbb\u7642\uff0c\u53caADG126 10 mg\/kg\uff0c\u6bcf3\u5468\u7d66\u85e5\uff0813\u540d\u60a3\u8005\uff09\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6cbb\u7642\u3002\u57fa\u65bc10 mg\/kg\u5291\u91cf\u6c34\u5e73\u6bcf3\u5468\u7d66\u85e5\u4e00\u6b21\u7684\u7d66\u85e5\u983b\u7387\u4e0b\u89c0\u5bdf\u5230\u66f4\u6709\u529b\u7684\u7642\u6548\u4fe1\u865f\uff0c\u6839\u64daSimon\u5169\u968e\u6bb5\u7684\u4e8c\u671f\u55ae\u81c2\u81e8\u5e8a\u8a66\u9a57\u8a2d\u8a08\uff0c\u516c\u53f8\u9700\u8981\u5728\u8a72\u7d66\u85e5\u65b9\u6848\u4e0b\u7e7c\u7e8c\u62db\u52df10\u4f8b\u60a3\u8005\uff0c\u5176\u521d\u6b65\u6709\u6548\u6027\u6578\u64da\u8a55\u4f30\u53ca\u7d71\u8a08\u5206\u6790\u9810\u8a08\u5c07\u65bc2023\u5e74\u5e95\u62162024\u5e74\u521d\u516c\u4f48\u3002   <\/p>\n<p>\u5176\u5b83\u6700\u65b0\u52d5\u614b<\/p>\n<p>\u7f85\u6c0f\uff1a \u6839\u64da<a href=\"\/Users\/ying_wu\/AppData\/Local\/Microsoft\/Windows\/INetCache\/Content.Outlook\/66JIWTMR\/2022%E5%B9%B412%E6%9C%88%E7%AD%BE%E8%AE%A2%E7%9A%84%E4%B8%B4%E5%BA%8A%E8%AF%95%E9%AA%8C%E5%90%88%E4%BD%9C%E5%8D%8F%E8%AE%AE\" target=\"_blank\" rel=\"noopener\">2022\u5e7412\u6708\u7c3d\u8a02\u7684\u81e8\u5e8a\u8a66\u9a57\u5408\u4f5c\u5354\u8b70<\/a>\uff0c\u7f85\u6c0f\u555f\u52d5\u4e86\u4e00\u9805\u8de8\u570b1b\/2\u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u5c0d\u7167\u7f85\u6c0f\u7684\u963f\u66ff\u5229\u73e0\u55ae\u6297\u548c\u8c9d\u4f10\u73e0\u55ae\u6297\u7684\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\uff0c\u8a55\u4f30ADG126\u806f\u5408\u963f\u66ff\u5229\u73e0\u55ae\u6297\u548c\u8c9d\u4f10\u73e0\u55ae\u6297\u4e4b\u4e09\u806f\u514d\u75ab\u7642\u6cd5\u5728\u665a\u671f\u809d\u7d30\u80de\u764c\uff08HCC\uff09\u7684\u4e00\u7dda\u6cbb\u7642\u4e2d\u7684\u6709\u6548\u6027\u8207\u5b89\u5168\u6027\u3002\u8a72\u96a8\u6a5f\u8a66\u9a57\u76ee\u524d\u5df2\u555f\u52d5\u60a3\u8005\u5165\u7d44\u5de5\u4f5c\uff0c\u8a08\u5283\u7d0d\u5165\u591a\u905460\u540d\u60a3\u8005\uff0c\u5229\u7528\u7f85\u6c0f\u816b\u7624\u514d\u75ab\u6cbb\u7642\u958b\u767c\u5e73\u53f0MORPHEUS\u9805\u76ee\u7684\u5168\u7403\u81e8\u5e8a\u8a66\u9a57\u7db2\u7d61\u3002\u7f85\u6c0f\u6b63\u8d0a\u52a9\u4e26\u958b\u5c55\u8a72\u8a66\u9a57\uff0c\u5929\u6f14\u5c07\u4fdd\u7559\u5c0dADG126\u7684\u5168\u7403\u958b\u767c\u8207\u5546\u54c1\u5316\u6b0a\u5229\u3002<br \/>\nExelixis\uff1a\u6839\u64da\u96d9\u65b9\u70ba\u958b\u767c\u539f\u5275\u63a9\u853d\u578b\u6297\u9ad4\u5076\u806f\u85e5\u7269\u800c\u9054\u6210\u7684\u6280\u8853\u6388\u6b0a\u5354\u8b70\uff0c2023\u5e746\u6708\uff0c\u5929\u6f14\u5728\u7b2c\u4e8c\u500b\u5408\u4f5c\u9805\u76ee\u4e2d\u6210\u529f\u7be9\u9078\u5230\u76ee\u6a19\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae\u5019\u9078\u85e5\u7269\uff0c\u4e26\u7372\u5f97\u4e00\u7b46\u4f86\u81eaExelixis\u7684300\u842c\u7f8e\u5143\u91cc\u7a0b\u7891\u4ed8\u6b3e\u3002<br \/>\n\u8cfd\u8afe\u83f2\uff1a\u5929\u6f14\u8207\u8cfd\u8afe\u83f2\u5ef6\u7e8c\u96d9\u65b9\u65bc2022\u5e743\u6708\u9054\u6210\u7684\u5408\u4f5c\uff0c\u958b\u767c\u96d9\u7279\u7570\u6027\u548c\u55ae\u514b\u9686SAFEbody\u00ae\u5019\u9078\u6297\u9ad4\uff0c\u5229\u7528\u5929\u6f14\u7684\u6280\u8853\u5236\u5099\u7684\u81e8\u5e8a\u524d\u5019\u9078\u6297\u9ad4\uff0c\u7531\u8cfd\u8afe\u83f2\u9032\u884c\u958b\u767c\u548c\u5546\u54c1\u5316\u3002<br \/>\nADC Therapeutics \uff08ADCT\uff09\uff1a\u622a\u81f3\u672c\u516c\u544a\u767c\u4f48\u4e4b\u65e5\uff0cADCT\u8207\u5929\u6f14\u65bc2019\u5e744\u6708\u7c3d\u8a02\u7684\u751f\u7269\u6750\u6599\u8f49\u79fb\u8207\u5408\u4f5c\u5354\u8b70\u5df2\u7d93\u5230\u671f\uff0cADCT\u9078\u64c7\u4e0d\u884c\u4f7f\u5176\u5c0d\u76f8\u95dc\u8a31\u53ef\u5354\u8b70\u7684\u9078\u64c7\u6b0a\u3002\u672a\u4f86\uff0c\u96d9\u65b9\u5c07\u4fdd\u6301\u958b\u653e\u614b\u5ea6\uff0c\u7e7c\u7e8c\u63a2\u7d22\u5728\u5275\u65b0\u6297\u9ad4\u7642\u6cd5\u7684\u767c\u73fe\u548c\u958b\u767c\u65b9\u9762\u7684\u5408\u4f5c\u6a5f\u6703\u3002<br \/>\nADG153\uff08\u6297CD47 IgG1\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae\uff09\uff1a\u5929\u6f14\u5728\u7f8e\u570b\u764c\u75c7\u5354\u6703\u5e74\u6703\u4e0a\u516c\u4f48\u7684\u6578\u64da\u986f\u793a\uff0cADG153\u5728\u81e8\u5e8a\u524d\u7814\u7a76\u4e2d\u5c55\u73fe\u51fa\u540c\u985e\u6700\u4f73\u6f5b\u529b\uff0cADG153\u662f\u4e00\u7a2eIgG1\u4e9e\u578b\u5019\u9078\u6297\u9ad4\uff0c\u63a1\u7528\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae\u7cbe\u6e96\u63a9\u853d\u6280\u8853\u512a\u5316\u5176\u5b89\u5168\u6027\uff0c\u6b63\u8655\u65bc\u65b0\u85e5\u7533\u8acb\u7684\u81e8\u5e8a\u524d\u7814\u7a76\u3002\u8a72<a href=\"\/Users\/ying_wu\/AppData\/Local\/Microsoft\/Windows\/INetCache\/Content.Outlook\/66JIWTMR\/poster%20presentation\" target=\"_blank\" rel=\"noopener\">\u6d77\u5831\u5c55\u793a<\/a>\u7e3d\u7d50\u4e86\u76f8\u95dc\u6578\u64da\uff0c\u8868\u660eADG153\u5728\u5be6\u9ad4\u7624\u6a21\u578b\u4e2d\u5c55\u73fe\u51fa\u5f37\u5927\u7684\u9ad4\u5167\u6297\u816b\u7624\u6d3b\u6027\uff0c\u4e14\u512a\u5148\u5728\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u8207CD47\u9776\u9ede\u7d50\u5408\uff0c\u56e0\u800c\u5177\u5099\u51fa\u773e\u7684\u5b89\u5168\u6027\u3002ADG153\u5177\u6709\u5f88\u5f37\u7684\u6297\u9ad4\u4f9d\u8cf4\u6027\u7d30\u80de\u4ecb\u5c0e\u7684\u7d30\u80de\u6bd2\u6027\u4f5c\u7528\uff08ADCC\uff09\u548c\u6297\u9ad4\u4f9d\u8cf4\u6027\u7d30\u80de\u4ecb\u5c0e\u7684\u541e\u566c\u4f5c\u7528\uff08ADCP\uff09\uff0c\u65e8\u5728\u5145\u5206\u91cb\u653e\u6297 CD47 \u6cbb\u7642\u8840\u6db2\u816b\u7624\u548c\u5be6\u9ad4\u60e1\u6027\u816b\u7624\u7684\u6f5b\u529b\u3002<br \/>\n\u8463\u4e8b\u6703\u6700\u65b0\u52d5\u614b\uff1a\u4eca\u5e748\u6708\uff0c\u5929\u6f14\u4efb\u547d\u6731\u529b\u535a\u58eb\u70ba\u8463\u4e8b\u6703\u6210\u54e1\u3002\u6731\u535a\u58eb\u81ea2020\u5e74\u8d77\u64d4\u4efb\u91d1\u65af\u745e\u53ca\u50b3\u5947\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\uff08Legend Biotech\uff09\u8463\u4e8b\uff0c\u76ee\u524d\u662f\u91d1\u65af\u745e\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\uff08Genscript Biotech Corporation\uff09\u7684\u9996\u5e2d\u6230\u7565\u5b98\uff0c\u5176\u5728\u4f01\u696d\u6230\u7565\u3001\u6230\u7565\u5408\u4f5c\u53ca\u806f\u76df\u7ba1\u7406\u65b9\u9762\u64c1\u6709\u8457\u8c50\u5bcc\u7684\u7d93\u9a57\uff0c\u5c24\u5176\u5728\u50b3\u5947\u751f\u7269\uff08\u91d1\u65af\u745e\u7684\u5b50\u516c\u53f8\uff09\u548c\u8de8\u570b\u85e5\u4f01\u6230\u7565\u5408\u4f5c\u8ac7\u5224\u7684\u65e9\u671f\u968e\u6bb5\u767c\u63ee\u4e86\u95dc\u9375\u4f5c\u7528\u3002<br \/>\u6b64\u5916\uff0c\u675c\u65b9\u52c7\u535a\u58eb\uff0c2020\u5e74\u8d77\u4efb\u5929\u6f14\u9996\u5e2d\u6280\u8853\u5b98\uff0c\u56e0\u500b\u4eba\u539f\u56e0\u9000\u51fa\u8463\u4e8b\u6703\u3002\u540c\u6642\uff0c\u516c\u53f8\u4efb\u547d\u5929\u6f14\u5275\u59cb\u5718\u968a\u6210\u54e1\uff0c\u751f\u7269\u4fe1\u606f\u79d1\u6280\u9ad8\u7d1a\u526f\u7e3d\u88c1\u674e\u8277\u64d4\u4efb\u8463\u4e8b\u4e00\u8077\u3002<br \/>\u4eca\u5e74\u65e9\u4e9b\u6642\u5019\uff0c\u5929\u6f14\u516c\u4f48\u4e86\u8463\u4e8b\u6703\u7684\u6700\u65b0\u52d5\u614b\uff1aMervyn Turner\u535a\u58eb\uff0c\u9ed8\u6c99\u6771\u7814\u7a76\u5be6\u9a57\u5ba4\uff08Merck research Laboratories\uff09\u524d\u5168\u7403\u8a31\u53ef\u548c\u5916\u90e8\u7814\u7a76\u90e8\u9580\u8ca0\u8cac\u4eba\uff0c\u88ab\u4efb\u547d\u70ba\u8463\u4e8b\uff1b\u738b\u96e8\u6fdb\u63a5\u66ff\u5b6b\u6a02\u975e\u64d4\u4efb\u7531\u6cdb\u5927\u897f\u6d0b\u6295\u8cc7\u96c6\u5718\u65b0\u52a0\u5761\u8fa6\u4e8b\u8655\uff08General Atlantic Singapore AI Pte. Ltd\uff09\u6307\u5b9a\u7684\u8463\u4e8b\uff1b\u5289\u6bd3\u6587\u56e0\u9996\u6b21\u4efb\u671f\u5c46\u6eff\uff0c\u8fad\u53bb\u8463\u4e8b\u6703\u53ca\u5be9\u8a08\u59d4\u54e1\u6703\u6210\u54e1\u8077\u52d9\u3002<br \/>\n\u79d1\u5b78\u9867\u554f\u59d4\u54e1\u6703\uff1a\u4eca\u5e743\u6708\uff0c<a href=\"\/Users\/ying_wu\/AppData\/Local\/Microsoft\/Windows\/INetCache\/Content.Outlook\/66JIWTMR\/Professor%20Aur%C3%A9lien%20Marabelle,%20MD,%20PhD\" target=\"_blank\" rel=\"noopener\">\u91ab\u5b78\u535a\u58ebAur\u00e9lien Marabelle\u6559\u6388<\/a>\u88ab\u4efb\u547d\u70ba\u516c\u53f8\u79d1\u5b78\u9867\u554f\u59d4\u54e1\u6703\u6210\u54e1\u3002Marabelle\u6559\u6388\u662f\u6cd5\u570bGustave Roussy\u764c\u75c7\u4e2d\u5fc3\u85e5\u7269\u958b\u767c\u90e8\uff08DITEP\uff09\u7684\u91ab\u5b78\u79d1\u5b78\u5bb6\uff0c\u4e5f\u662f\u816b\u7624\u5b78\u548c\u514d\u75ab\u5b78\u9818\u57df\u7684\u5c08\u5bb6\u3002\u4ed6\u5728\u816b\u7624\u7279\u7570\u6027\u8abf\u7bc0\u6027T\u7d30\u80de\uff08Treg\uff09\u6e05\u9664\u65b9\u9762\u64c1\u6709\u6df1\u523b\u898b\u89e3\uff0c\u958b\u5275\u6027\u5730\u5f15\u5165\u816b\u7624\u5167\u800c\u975e\u7cfb\u7d71\u7d66\u85e5\u6297CTLA-4\u7642\u6cd5\uff0c\u5f9e\u800c\u514b\u670d\u6297CTLA-4\u7642\u6cd5\u5291\u91cf\u4f9d\u8cf4\u6027\u6bd2\u6027\u554f\u984c\u3002  <\/p>\n<p>\u8ca1\u52d9\u4eae\u9ede<\/p>\n<p>\u73fe\u91d1\u548c\u73fe\u91d1\u7b49\u50f9\u7269<br \/>\u73fe\u91d1\u548c\u73fe\u91d1\u7b49\u50f9\u72692022\u5e7412\u670831\u65e5\u7d0414,380\u842c\u7f8e\u5143\uff0c2023\u5e746\u670830\u65e5\u7d0412,880\u842c\u7f8e\u5143\u3002<\/p>\n<p>\u622a\u81f32023\u5e746\u670830\u65e5\uff0c\u516c\u53f8\u5f9e\u4e2d\u570b\u5883\u5167\u5404\u5546\u696d\u9280\u884c\u7372\u5f97\u7684\u4eba\u6c11\u5e63\u8cb8\u6b3e\u75312022\u5e7412\u670831\u65e5\u76842,780\u842c\u7f8e\u5143\u6e1b\u5c11\u81f32023\u5e746\u670830\u65e5\u76842,490\u842c\u7f8e\u5143\u3002\u5f9e\u8cb8\u6b3e\u4e2d\u6240\u7372\u5f97\u8cc7\u91d1\u4e3b\u8981\u7528\u4f86\u652f\u4ed8\u516c\u53f8\u5728\u4e2d\u570b\u5883\u5167\u7522\u751f\u7684\u7814\u767c\u8cbb\u7528\uff0c\u5305\u62ec\u5728\u81e8\u5e8a\u53ca\u81e8\u5e8a\u524d\u7814\u767c\u9805\u76ee\u4e2d\u7522\u751f\u7684CMC\u8cbb\u7528\u3002<\/p>\n<p>\u6de8\u6536\u5165<br \/>\u6de8\u6536\u5165\u540c\u6bd4\u589e\u9577\u4e86\u7d04341%\u3002\u6de8\u6536\u5165\u76f8\u8f03\u65bc2022\u5e74\u540c\u671f\u7684390\u842c\u7f8e\u5143\u589e\u52a0\u52302023\u5e746\u670830\u65e51,730\u842c\u7f8e\u5143\u3002\u8a72\u589e\u9577\u5305\u542b\u4e86\u56e0\u516c\u53f8\u5c65\u884c\u4e86\u8207\u8cfd\u8afe\u83f2\u548cExelixis\u6240\u5206\u5225\u7c3d\u8a02\u7684\u6280\u8853\u5408\u4f5c\u548c\u6388\u6b0a\u5354\u8b70\u4e2d\u7684\u5c65\u7d04\u7fa9\u52d9\u800c\u78ba\u8a8d\u7684\u6536\u5165\u3002\u6de8\u6536\u5165\u4e5f\u5305\u542b\u4e86\u65bc2023\u5e746\u6708\u5f9eExelixis\u6536\u5230\u7684300\u842c\u7f8e\u5143\u91cc\u7a0b\u7891\u4ed8\u6b3e\u3002<\/p>\n<p>\u7814\u767c\u8cbb\u7528<\/p>\n<p>\u7814\u767c\u8cbb\u7528\u540c\u6bd4\u4e0b\u964d\u4e86\u7d0453%\u3002\u7814\u767c\u8cbb\u7528\u76f8\u8f03\u65bc2022\u5e74\u540c\u671f\u76844,510\u842c\u7f8e\u5143\u4e0b\u964d\u52302023\u5e746\u670830\u65e5\u76842,130\u842c\u7f8e\u5143\u3002\u8a72\u4e0b\u964d\u6e90\u65bc\u81e8\u5e8a\u524d\u9805\u76ee\u652f\u51fa\u7684\u6e1b\u5c11\u548cADG106\u76f8\u95dc\u7684\u81e8\u5e8a\u9805\u76ee\u7684\u9010\u6f38\u6536\u5c3e\uff0c\u8207\u91dd\u5c0d\u6297CTLA-4\u7642\u6cd5\u589e\u52a0\u7684\u6295\u5165\u6240\u62b5\u6d88\u3002\u516c\u53f8\u91cd\u9ede\u767c\u5c55\u512a\u8cea\u81e8\u5e8a\u9805\u76ee\uff0c\u4e26\u63a1\u53d6\u4e86\u5305\u62ec\u6e1b\u5c11\u4eba\u54e1\u6210\u672c\u5728\u5167\u7684\u4e00\u7cfb\u5217\u6210\u672c\u63a7\u5236\u63aa\u65bd\u3002<\/p>\n<p>\u7ba1\u7406\u8cbb\u7528<br \/>\u7ba1\u7406\u8cbb\u7528\u76f8\u8f03\u65bc2022\u5e74\u540c\u671f\u7684680\u842c\u7f8e\u5143\u6e1b\u5c11\u52302023\u5e746\u670830\u65e5\u7684450\u842c\u7f8e\u5143\u3002\u7ba1\u7406\u8cbb\u7528\u7684\u6e1b\u5c11\u4e3b\u8981\u662f\u7531\u65bc\u6210\u672c\u63a7\u5236\u5e36\u4f86\u7684\u4eba\u5de5\u53ca\u8fa6\u516c\u6210\u672c\u7684\u6e1b\u5c11\u3002<\/p>\n<p>\u5176\u4ed6\u71df\u696d\u6536\u5165<br \/>\u5176\u4ed6\u71df\u696d\u6536\u51652023\u5e746\u670830\u65e5\u7d04340\u842c\u7f8e\u5143\u3002\u5176\u4ed6\u71df\u696d\u6536\u5165\u5305\u542b\u4e86\u5f9e\u4e00\u5bb6\u5408\u540c\u88fd\u9020\u5546\u8655\u7372\u5f97\u7684\uff0c\u91dd\u5c0d\u516c\u53f8\u5728\u4e00\u4efd\u81e8\u5e8a\u524d\u9805\u76ee\u5916\u5305\u5354\u8b70\u4e2d\u7522\u751f\u7684\u640d\u5931\u7684\u4e00\u6b21\u6027\u88dc\u511f\u6b3e\u3002<\/p>\n<p>\u6de8\u8667\u640d<br \/>\u6de8\u8667\u640d\u76f8\u8f03\u65bc2022\u5e74\u540c\u671f\u76844,760\u842c\u7f8e\u5143\u6e1b\u5c11\u52302023\u5e746\u670830\u65e5\u7684410\u842c\u7f8e\u5143\u3002<\/p>\n<p>\u6d41\u901a\u5728\u5916\u666e\u901a\u80a1<br \/>\u622a\u6b62\u81f32023\u5e746\u670830\u65e5\uff0c\u516c\u53f8\u6d41\u901a\u5728\u5916\u7684\u666e\u901a\u80a1\u70ba54,793,339\u80a1\u3002\u6bcf\u4e00\u80a1\u7f8e\u570b\u5b58\u6258\u80a1\u7968(ADS)\u53ef\u63db\u7b97\u70ba1.25\u80a1\u666e\u901a\u80a1\u3002<\/p>\n<p>\u975e\u7f8e\u570b\u901a\u7528\u6703\u8a08\u6e96\u5247\uff08Non-GAAP\uff09\u4e0b\u7684\u8667\u640d<br \/>\u975e\u7f8e\u570b\u901a\u7528\u6703\u8a08\u6e96\u5247\u4e0b\u7684\u6de8\u8667\u640d\u5b9a\u7fa9\u70ba\u8a72\u671f\u9593\u7684\u7f8e\u570b\u901a\u7528\u6703\u8a08\u6e96\u5247\u4e0b\u7684\u6de8\u8667\u640d\u5254\u9664\u80a1\u6b0a\u6fc0\u52f5\u8cbb\u7528\u3002\u8a72\u91d1\u984d\u5f9e2022\u5e74\u540c\u671f\u7684\u6de8\u8667\u640d4,190\u842c\u7f8e\u5143\uff0c\u4e0b\u964d\u81f32023\u5e746\u670830\u65e5\u768410\u842c\u7f8e\u5143\u3002\u8acb\u53c3\u95b1\u672c\u65b0\u805e\u7a3f\u4e2d\u984c\u70ba\u300c\u7f8e\u570b\u901a\u7528\u6703\u8a08\u6e96\u5247\uff08GAAP\uff09\u548c\u975e\u7f8e\u570b\u901a\u7528\u6703\u8a08\u6e96\u5247\uff08Non-GAAP\uff09\u4e0b\u7684\u696d\u7e3e\u8abf\u7bc0\u8868\u300d\u90e8\u5206\u77ad\u89e3\u8a73\u60c5\u3002<\/p>\n<p>\u5929\u6f14\u85e5\u696d\u4f7f\u7528Non-GAAP\u6de8\u8667\u640d\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u6de8\u8667\u640d\uff0c\u7528\u65bc\u8a55\u4f30\u672c\u516c\u53f8\u7684\u7d93\u71df\u6210\u679c\uff0c\u4ee5\u53ca\u8ca1\u52d9\u548c\u7d93\u71df\u6c7a\u7b56\u3002\u672c\u516c\u53f8\u8a8d\u70ba\uff0cNon-GAAP\u6de8\u8667\u640d\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u6de8\u8667\u640d\u6709\u52a9\u65bc\u8b58\u5225\u672c\u516c\u53f8\u696d\u52d9\u7684\u57fa\u672c\u8da8\u52e2\uff0c\u800c\u9019\u4e9b\u8da8\u52e2\u53ef\u80fd\u56e0\u672c\u516c\u53f8\u8a08\u5165\u672c\u671f\u9593\u8667\u640d\u7684\u67d0\u4e9b\u8cbb\u7528\u7684\u5f71\u97ff\u800c\u626d\u66f2\u3002\u672c\u516c\u53f8\u8a8d\u70ba\uff0cNon-GAAP\u6de8\u8667\u640d\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u6de8\u8667\u640d\u63d0\u4f9b\u4e86\u6709\u95dc\u5176\u7d93\u71df\u6210\u679c\u7684\u6709\u7528\u4fe1\u606f\uff0c\u6574\u9ad4\u63d0\u5347\u4e86\u5c0d\u5176\u904e\u53bb\u696d\u7e3e\u548c\u672a\u4f86\u524d\u666f\u7684\u5168\u9762\u77ad\u89e3\uff0c\u4e26\u4f7f\u7ba1\u7406\u5c64\u5728\u8ca1\u52d9\u548c\u904b\u71df\u6c7a\u7b56\u4e2d\u4f7f\u7528\u7684\u95dc\u9375\u6307\u6a19\u66f4\u5177\u53ef\u898b\u6027\u3002<\/p>\n<p>\u5c0d\u65bc\u672c\u671f\u9593\u7684Non-GAAP\u8ca1\u52d9\u6307\u6a19\u7684\u8861\u91cf\uff0c\u5929\u6f14\u85e5\u696d\u4f7f\u7528\u7684Non-GAAP\u6de8\u8667\u640d\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u6de8\u8667\u640d\u4e0d\u61c9\u55ae\u7368\u88ab\u8003\u616e\uff0c\u4e5f\u4e0d\u61c9\u88ab\u8996\u70ba\u8a72\u671f\u9593\u71df\u696d\u5229\u6f64\u3001\u6de8\u8667\u640d\u6216\u4efb\u4f55\u5176\u4ed6\u696d\u7e3e\u8861\u91cf\u6307\u6a19\u7684\u66ff\u4ee3\u54c1\uff0c\u6216\u4f5c\u70ba\u5176\u7d93\u71df\u696d\u7e3e\u7684\u8861\u91cf\u6307\u6a19\u3002\u516c\u53f8\u9f13\u52f5\u6295\u8cc7\u8005\u5be9\u95b1\u8a72\u671f\u9593\u7684Non-GAAP\u6de8\u8667\u640d\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u6de8\u8667\u640d\uff0c\u4e26\u5be9\u95b1\u6700\u76f4\u63a5\u53ef\u6bd4\u7684\u7f8e\u570b\u901a\u7528\u6703\u8a08\u6e96\u5247\u4e0b\u8ca1\u52d9\u6307\u6a19\u7684\u8abf\u6574\u904e\u7a0b\u3002\u6b64\u8655\u6240\u5217\u671f\u9593\u7684Non-GAAP\u6de8\u8667\u640d\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u6de8\u8667\u640d\u53ef\u80fd\u7121\u6cd5\u8207\u5176\u4ed6\u516c\u53f8\u63d0\u4f9b\u7684\u985e\u4f3c\u540d\u7a31\u7684\u8ca1\u52d9\u6307\u6a19\u76f8\u6bd4\u8f03\u3002\u5176\u4ed6\u516c\u53f8\u53ef\u80fd\u6703\u4ee5\u4e0d\u540c\u7684\u65b9\u5f0f\u8a08\u7b97\u985e\u4f3c\u7684\u8ca1\u52d9\u6307\u6a19\uff0c\u5f9e\u800c\u9650\u5236\u4e86\u5b83\u5011\u4f5c\u70ba\u516c\u53f8\u53ef\u6bd4\u6578\u64da\u7684\u6709\u7528\u6027\u3002\u5929\u6f14\u85e5\u696d\u9f13\u52f5\u6295\u8cc7\u8005\u548c\u5176\u4ed6\u4eba\u5168\u9762\u5be9\u95b1\u672c\u516c\u53f8\u7684\u8ca1\u52d9\u4fe1\u606f\uff0c\u800c\u4e0d\u662f\u50c5\u50c5\u95dc\u6ce8\u65bc\u55ae\u4e00\u7684\u8ca1\u52d9\u6307\u6a19\u3002<\/p>\n<p>\u672c\u671f\u9593\u8a08\u7b97\u7684\u6de8\u5229\u6f64\u6307\u6a19\u4e0bNon-GAAP\u6de8\u8667\u640d\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u6de8\u8667\u640d\uff0c\u4e0d\u5305\u62ec\u80a1\u6b0a\u6fc0\u52f5\u8cbb\u7528\u3002\u80a1\u6b0a\u6fc0\u52f5\u8cbb\u7528\u662f\u5411\u54e1\u5de5\u6388\u4e88\u80a1\u7968\u6fc0\u52f5\u6240\u7522\u751f\u7684\u975e\u73fe\u91d1\u8cbb\u7528\u3002\u6211\u5011\u8a8d\u70ba\u7f8e\u570b\u901a\u7528\u6703\u8a08\u6e96\u5247\u548c\u975e\u7f8e\u570b\u901a\u7528\u6703\u8a08\u6e96\u5247\u7684\u8abf\u6574\u4fe1\u606f\u80fd\u5c0d\u7ba1\u7406\u5c64\u548c\u6295\u8cc7\u4eba\u5728\u9032\u884c\u516c\u53f8\u904b\u71df\u8868\u73fe\u7684\u540c\u671f\u6bd4\u8f03\u4ee5\u53ca\u540c\u696d\u6bd4\u8f03\u6642\u6709\u6240\u52a9\u76ca\u3002\u5176\u539f\u56e0\u6709\uff1a\uff08i\uff09\u5728\u67d0\u7279\u5b9a\u671f\u9593\u5167\u7684\u80a1\u6b0a\u6fc0\u52f5\u8cbb\u7528\u8207\u516c\u53f8\u7684\u904b\u71df\u8868\u73fe\u672a\u5fc5\u76f4\u63a5\u76f8\u95dc\uff1b\uff08ii\uff09\u56e0\u516c\u53f8\u6388\u4e88\u65b0\u7684\u80a1\u6b0a\u6fc0\u52f5\u8a08\u5283\u7684\u6642\u9593\u5b89\u6392\uff0c\u80a1\u6b0a\u6fc0\u52f5\u8cbb\u7528\u5728\u4e0d\u540c\u671f\u9593\u5167\u53ef\u80fd\u6703\u767c\u751f\u8f03\u5927\u8b8a\u5316\uff1b\u4ee5\u53ca\uff0c\uff08iii\uff09\u5176\u4ed6\u516c\u53f8\u53ef\u80fd\u63a1\u53d6\u4e0d\u540c\u7684\u80a1\u6b0a\u6fc0\u52f5\u5f62\u5f0f\u6216\u8005\u4f7f\u7528\u4e0d\u540c\u7684\u4f30\u503c\u65b9\u6cd5\u3002<\/p>\n<p>\u8acb\u53c3\u95b1\u672c\u516c\u544a\u7d50\u5c3e\u7684\u300c\u7f8e\u570b\u901a\u7528\u6703\u8a08\u6e96\u5247\uff08GAAP\uff09\u548c\u975e\u7f8e\u570b\u901a\u7528\u6703\u8a08\u6e96\u5247\uff08Non-GAAP\uff09\u4e0b\u7684\u696d\u7e3e\u8abf\u7bc0\u8868\u300d\uff0c\u7372\u53d6\u672c\u671f\u9593Non-GAAP\u6de8\u8667\u640d\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u6de8\u8667\u640d\u7684\u5b8c\u6574\u7684\u8abf\u6574\u904e\u7a0b\u3002<\/p>\n<p>\u95dc\u65bc\u5929\u6f14\u85e5\u696d<\/p>\n<p>\u5929\u6f14\u85e5\u696d\uff08\u7d0d\u65af\u9054\u514b\u80a1\u7968\u4ee3\u78bc\uff1aADAG\uff09\u662f\u5e73\u53f0\u9a45\u52d5\u4e26\u64c1\u6709\u81ea\u4e3b\u5e73\u53f0\u7522\u51fa\u7684\u81e8\u5e8a\u7522\u54c1\u958b\u767c\u968e\u6bb5\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u516c\u53f8\u81f4\u529b\u65bc\u767c\u73fe\u4e26\u958b\u767c\u4ee5\u539f\u5275\u6297\u9ad4\u70ba\u57fa\u77f3\u7684\u65b0\u578b\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u3002\u501f\u529b\u65bc\u8a08\u7b97\u751f\u7269\u5b78\u8207\u4eba\u5de5\u667a\u80fd\uff0c\u6191\u501f\u5176\u5168\u7403\u9996\u5275\u7684\u4e09\u9ad4\u5e73\u53f0\u6280\u8853\uff08\u65b0\u8868\u4f4d\u6297\u9ad4NEObody\u2122\uff0c\u5b89\u5168\u6297\u9ad4SAFEbody\u00ae\u53ca\u5f37\u529b\u6297\u9ad4POWERbody\u2122\uff09\uff0c\u5929\u6f14\u85e5\u696d\u5df2\u5efa\u7acb\u8d77\u805a\u7126\u65bc\u65b0\u578b\u816b\u7624\u514d\u75ab\u7642\u6cd5\u7684\u7368\u7279\u539f\u5275\u7684\u6297\u9ad4\u7522\u54c1\u7dda\uff0c\u4ee5\u89e3\u6c7a\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u3002\u5929\u6f14\u5df2\u548c\u591a\u500b\u5168\u7403\u77e5\u540d\u5408\u4f5c\u5925\u4f34\u9054\u6210\u4e86\u6230\u7565\u5408\u4f5c\u95dc\u4fc2\uff0c\u4e26\u4ee5\u5176\u591a\u7a2e\u539f\u5275\u524d\u6cbf\u79d1\u6280\u70ba\u5408\u4f5c\u5925\u4f34\u7684\u65b0\u85e5\u7814\u767c\u8ce6\u80fd\u3002<\/p>\n<p>\u5982\u9700\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\uff1a\u00a0<a href=\"https:\/\/investor.adagene.com\/\" target=\"_blank\" rel=\"noopener\">https:\/\/investor.adagene.com\u00a0<\/a>\u4e26\u95dc\u6ce8\u5929\u6f14\u85e5\u696d<a href=\"https:\/\/t.prnasia.com\/t\/qgUNymgw\" target=\"_blank\" rel=\"noopener\">\u5fae\u4fe1<\/a>\u3001<a href=\"https:\/\/t.prnasia.com\/t\/QuTV1aBS\" target=\"_blank\" rel=\"noopener\">\u9818\u82f1<\/a>\u53ca<a href=\"https:\/\/t.prnasia.com\/t\/9qfrA1Nr\" target=\"_blank\" rel=\"noopener\">\u63a8\u7279<\/a>\u5b98\u65b9\u5e33\u865f\u3002<\/p>\n<p>SAFEbody\u00ae \u70ba\u5929\u6f14\u5728\u7f8e\u570b\u3001\u4e2d\u570b\u3001\u6fb3\u5927\u5229\u4e9e\u3001\u65e5\u672c\u3001\u65b0\u52a0\u5761\u548c\u6b50\u76df\u7684\u8a3b\u518a\u5546\u6a19\u3002<\/p>\n<p>\u5b89\u5168\u6e2f\u8072\u660e\u00a0<\/p>\n<p>\u672c\u65b0\u805e\u7a3f\u5305\u542b\u524d\u77bb\u6027\u9673\u8ff0\uff0c\u5305\u62ec\u95dc\u65bc\u81e8\u5e8a\u6578\u64da\u5c0d\u60a3\u8005\u7684\u6f5b\u5728\u5f71\u97ff\u7684\u9673\u8ff0\uff0c\u4ee5\u53ca\u5929\u6f14\u85e5\u696d\u7684\u63a8\u9032\u548c\u9810\u671f\u7684\u81e8\u5e8a\u524d\u6d3b\u52d5\u3001\u81e8\u5e8a\u958b\u767c\u3001\u76e3\u7ba1\u91cc\u7a0b\u7891\u4ee5\u53ca\u5176\u5019\u9078\u7522\u54c1\u7684\u5546\u696d\u5316\u3002\u7531\u65bc\u5404\u7a2e\u91cd\u8981\u56e0\u7d20\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u65bc\u5929\u6f14\u85e5\u696d\u8b49\u660e\u5176\u5019\u9078\u85e5\u7269\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u80fd\u529b\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u8207\u524d\u77bb\u6027\u9673\u8ff0\u4e2d\u6240\u793a\u7684\u7d50\u679c\u5b58\u5728\u91cd\u5927\u5dee\u7570\uff1b\u5176\u5019\u9078\u85e5\u7269\u7684\u81e8\u5e8a\u7d50\u679c\uff0c\u53ef\u80fd\u4e0d\u652f\u6301\u9032\u4e00\u6b65\u958b\u767c\u6216\u76e3\u7ba1\u6279\u51c6\uff1b\u76f8\u95dc\u76e3\u7ba1\u6a5f\u69cb\u5c31\u5929\u6f14\u85e5\u696d\u5019\u9078\u85e5\u7269\u7684\u76e3\u7ba1\u6279\u51c6\u505a\u51fa\u6c7a\u5b9a\u7684\u5167\u5bb9\u548c\u6642\u9593\uff1b\u5982\u679c\u7372\u5f97\u6279\u51c6\uff0c\u5929\u6f14\u85e5\u696d\u70ba\u5176\u5019\u9078\u85e5\u7269\u53d6\u5f97\u5546\u696d\u6210\u529f\u7684\u80fd\u529b\uff1b\u5929\u6f14\u85e5\u696d\u70ba\u5176\u6280\u8853\u548c\u85e5\u7269\u7372\u5f97\u548c\u7dad\u6301\u77e5\u8b58\u7522\u6b0a\u4fdd\u8b77\u7684\u80fd\u529b\uff1b\u5929\u6f14\u85e5\u696d\u4f9d\u8cf4\u7b2c\u4e09\u65b9\u9032\u884c\u85e5\u7269\u958b\u767c\u3001\u88fd\u9020\u548c\u5176\u4ed6\u670d\u52d9\uff1b\u5929\u6f14\u85e5\u696d\u6709\u9650\u7684\u7d93\u71df\u6b77\u53f2\u4ee5\u53ca\u5929\u6f14\u85e5\u696d\u7372\u5f97\u984d\u5916\u904b\u71df\u8cc7\u91d1\u4ee5\u53ca\u5b8c\u6210\u5176\u5019\u9078\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u7684\u80fd\u529b\uff1b\u5929\u6f14\u85e5\u696d\u5728\u5176\u73fe\u6709\u6230\u7565\u5925\u4f34\u95dc\u4fc2\u6216\u5408\u4f5c\u4e4b\u5916\u7c3d\u8a02\u984d\u5916\u5408\u4f5c\u5354\u8b70\u7684\u80fd\u529b\uff0c\u4ee5\u53caCOVID-19 \u6d41\u884c\u5c0d\u5929\u6f14\u85e5\u696d\u81e8\u5e8a\u958b\u767c\u3001\u5546\u696d\u548c\u5176\u4ed6\u904b\u71df\u7684\u5f71\u97ff\uff0c\u4ee5\u53ca\u5728\u5929\u6f14\u63d0\u4ea4\u7d66\u7f8e\u570b\u8b49\u5238\u4ea4\u6613\u59d4\u54e1\u6703\u768420-F\u5f62\u5f0f\u76842022\u5e74\u7684\u5e74\u5ea6\u5831\u544a\u4e2d\u300c\u98a8\u96aa\u56e0\u7d20\u300d\u90e8\u5206\u66f4\u5145\u5206\u8a0e\u8ad6\u7684\u90a3\u4e9b\u98a8\u96aa\u3002\u6240\u6709\u524d\u77bb\u6027\u9673\u8ff0\u5747\u57fa\u65bc\u5929\u6f14\u85e5\u696d\u7576\u524d\u53ef\u7372\u5f97\u7684\u4fe1\u606f\uff0c\u9664\u975e\u4f9d\u7167\u6cd5\u5f8b\u4e4b\u53ef\u80fd\u8981\u6c42\uff0c\u5929\u6f14\u85e5\u696d\u4e0d\u627f\u64d4\u56e0\u65b0\u4fe1\u606f\u3001\u672a\u4f86\u4e8b\u4ef6\u6216\u5176\u4ed6\u539f\u56e0\u800c\u516c\u958b\u66f4\u65b0\u6216\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9673\u8ff0\u7684\u7fa9\u52d9\u3002<\/p>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n<div>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u8ca1\u52d9\u5831\u8868<\/span><\/p>\n<p>     <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u672a\u7d93\u5be9\u8a08\u7684\u5408\u4f75\u8cc7\u7522\u8ca0\u50b5\u8868\uff08\u7f8e\u570b\u901a\u7528\u6703\u8a08\u6e96\u5247\uff09<\/span><\/p>\n<p class=\"prngen16\"><span class=\"prnews_span\">\u622a\u6b62\u81f32022\u5e74<br \/>12\u670831\u65e5<\/span><\/p>\n<p>      <\/p>\n<p class=\"prngen16\"><span class=\"prnews_span\">\u622a\u6b62\u81f32023\u5e74<br \/>6\u670830\u65e5<\/span><\/p>\n<p>      <\/p>\n<p class=\"prngen16\"><span class=\"prnews_span\">US$<\/span><\/p>\n<p>      <\/p>\n<p class=\"prngen16\"><span class=\"prnews_span\">US$<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u8cc7\u7522<\/span><\/p>\n<p>     <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u6d41\u52d5\u8cc7\u7522:<\/span><\/p>\n<p>     <\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u73fe\u91d1\u53ca\u73fe\u91d1\u7b49\u50f9\u7269<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">143,758,678<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">128,759,962<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u61c9\u6536\u95dc\u806f\u65b9\u6b3e\u9805<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">619,432<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">393,969<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5176\u4ed6\u6d41\u52d5\u8cc7\u7522\u548c\u9810\u4ed8\u8cec\u6b3e<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">4,937,323<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">3,524,688<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u6d41\u52d5\u8cc7\u7522\u7e3d\u984d<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">149,315,433<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">132,678,619<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u56fa\u5b9a\u8cc7\u7522<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">2,782,963<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">2,222,200<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u4f7f\u7528\u6b0a\u8cc7\u7522<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">191,877<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">292,523<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5176\u4ed6\u975e\u6d41\u52d5\u8cc7\u7522<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">109,572<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">108,922<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u8cc7\u7522\u7e3d\u984d<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">152,399,845<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">135,302,264<\/span><\/p>\n<p class=\"prnml4\">\u00a0<\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u8ca0\u50b5\u548c\u80a1\u6771\u6b0a\u76ca<\/span><\/p>\n<p>     <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u6d41\u52d5\u8ca0\u50b5:<\/span><\/p>\n<p>     <\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u61c9\u4ed8\u8cec\u6b3e<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">3,666,124<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">4,483,776<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5408\u540c\u8ca0\u50b5<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">15,107,276<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">812,916<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u61c9\u4ed8\u95dc\u806f\u65b9\u6b3e\u9805<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">19,323,337<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">17,216,032<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u9810\u63d0\u53ca\u5176\u4ed6\u6d41\u52d5\u8ca0\u50b5<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">3,212,809<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">2,834,565<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u61c9\u4ed8\u6240\u5f97\u7a05<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u2014<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">1,895,063<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u77ed\u671f\u501f\u6b3e<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">10,768,745<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">8,995,544<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u4e00\u5e74\u5167\u5230\u671f\u7684\u9577\u671f\u501f\u6b3e<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">2,850,128<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">2,594,868<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u4e00\u5e74\u5167\u5230\u671f\u7684\u79df\u8cc3\u8ca0\u50b5<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">151,983<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">158,859<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u6d41\u52d5\u8ca0\u50b5\u7e3d\u984d<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">55,080,402<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">38,991,623<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u9577\u671f\u501f\u6b3e<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">14,146,541<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">13,348,003<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u79df\u8cc3\u8ca0\u50b5<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">53,834<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">141,431<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5176\u4ed6\u975e\u6d41\u52d5\u8ca0\u50b5<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">28,718<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">27,679<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u8ca0\u50b5\u7e3d\u984d<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">69,309,495<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">52,508,736<\/span><\/p>\n<p class=\"prnml4\">\u00a0<\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u80a1\u6771\u6b0a\u76ca:<\/span><\/p>\n<p>     <\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u80a1\u672c<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">5,497<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">5,556<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5eab\u5b58\u80a1<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(4)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(4)<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u8cc7\u672c\u516c\u7a4d<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">342,739,268<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">346,958,523<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5176\u4ed6\u7d9c\u5408\u8667\u640d<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(849,305)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(1,256,635)<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u7d2f\u8a08\u8667\u640d<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(258,805,106)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(262,913,912)<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u80a1\u6771\u6b0a\u76ca\u7e3d\u984d<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">83,090,350<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">82,793,528<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u8ca0\u50b5\u548c\u80a1\u6771\u6b0a\u76ca\u7e3d\u984d<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">152,399,845<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">135,302,264<\/span><\/p>\n<\/div>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n<div>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u672a\u7d93\u5be9\u8a08\u7684\u5408\u4f75\u5229\u6f64\u8868 \uff08\u7f8e\u570b\u901a\u7528\u6703\u8a08\u6e96\u5247\uff09<\/span><\/p>\n<p>      <\/p>\n<p class=\"prngen16\"><span class=\"prnews_span\">\u622a\u81f36\u670830\u65e5\u76846\u500b\u6708<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">2022<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">2023<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u6536\u5165<\/span><\/p>\n<p>     <\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u6280\u8853\u8a31\u53ef\u5408\u4f5c<\/span><span class=\"prnews_span\">\u6536\u5165<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">3,923,174<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">17,295,745<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u8cbb\u7528<\/span><\/p>\n<p>     <\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u7814\u767c\u8cbb\u7528<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(45,148,357)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(21,289,434)<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u7ba1\u7406\u8cbb\u7528<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(6,848,925)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(4,470,520)<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u8cbb\u7528\u7e3d\u984d<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(51,997,282)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(25,759,954)<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5176\u4ed6\u71df\u696d\u6536\u5165<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u2014<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">3,415,230<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u71df\u696d\u8667\u640d<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(48,074,108)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(5,048,979)<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5229\u606f\u6536\u5165<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">14,931<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">1,918,971<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5229\u606f\u8cbb\u7528<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(211,434)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(573,507)<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5176\u4ed6\u6536\u5165<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">430,671<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">3,702,660<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u532f\u514c\u640d\u76ca<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">756,085<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">1,620,415<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u7a05\u524d\u8667\u640d<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(47,083,855)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(1,795,670)<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u6240\u5f97\u7a05\u8cbb\u7528<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(558,944)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(2,313,136)<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u6de8\u8667\u640d<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(47,642,799)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(4,108,806)<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u5176\u4ed6\u7d9c\u5408\u6536\u76ca<\/span><\/p>\n<p>     <\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u5916\u5e63\u5831\u8868\u6298\u7b97\u5dee\u7570<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">284,148<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(407,330)<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u7d9c\u5408\u8667\u640d\u7e3d\u984d<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(47,358,651)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(4,516,136)<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u6de8\u8667\u640d<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(47,642,799)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(4,108,806)<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u6b78\u5c6c\u65bc\u666e\u901a\u80a1\u80a1\u6771\u6de8\u8667\u640d\u7e3d\u984d<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(47,642,799)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(4,108,806)<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u7528\u65bc\u8a08\u7b97\u6bcf\u80a1\u666e\u901a\u80a1\u6de8\u640d\u5931\u7684\u52a0\u6b0a\u5e73\u5747\u666e\u901a\u80a1\u80a1\u6578:<\/span><\/p>\n<p>     <\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u2014\u57fa\u672c<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">54,533,161<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">54,604,787<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u2014\u7a00\u91cb\u5f8c<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">54,533,161<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">54,604,787<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u6bcf\u80a1\u666e\u901a\u80a1\u6de8\u8667\u640d<\/span><\/p>\n<p>     <\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u2014\u57fa\u672c<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(0.87)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(0.08)<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u2014\u7a00\u91cb\u5f8c<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(0.87)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(0.08)<\/span><\/p>\n<\/div>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n<div>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u7f8e\u570b\u901a\u7528\u6703\u8a08\u6e96\u5247\uff08GAAP\uff09\u548c\u975e\u7f8e\u570b\u901a\u7528\u6703\u8a08\u6e96\u5247\uff08Non-GAAP\uff09\u4e0b\u7684\u696d\u7e3e\u8abf\u7bc0\u8868<\/span><\/p>\n<p>      <\/p>\n<p class=\"prngen16\"><span class=\"prnews_span\">\u622a\u81f36\u670830\u65e5\u76846\u500b\u6708<\/span><\/p>\n<p>      <\/p>\n<p class=\"prngen16\"><span class=\"prnews_span\">2022\u5e74<\/span><\/p>\n<p>      <\/p>\n<p class=\"prngen16\"><span class=\"prnews_span\">2023\u5e74<\/span><\/p>\n<p>      <\/p>\n<p class=\"prngen16\"><span class=\"prnews_span\">US$<\/span><\/p>\n<p>      <\/p>\n<p class=\"prngen16\"><span class=\"prnews_span\">US$<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u7f8e\u570b\u901a\u7528\u6703\u8a08\u6e96\u5247\u4e0b\u6b78\u5c6c\u65bc\u666e\u901a\u80a1\u80a1\u6771\u6de8\u8667\u640d\u7e3d\u984d<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(47,642,799)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(4,108,806)<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u8abf\u6574:\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><\/p>\n<p>     <\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u80a1\u6b0a\u6fc0\u52f5\u8cbb\u7528<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">5,725,868<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">4,030,214<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u975e\u7f8e\u570b\u901a\u7528\u6703\u8a08\u6e96\u5247\u4e0b\u7684\u666e\u901a\u80a1\u80a1\u6771\u6de8\u8667\u640d\u7e3d\u984d<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(41,916,931)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(78,592)<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u7528\u65bc\u8a08\u7b97\u6bcf\u80a1\u666e\u901a\u80a1\u6de8\u640d\u5931\u7684\u52a0\u6b0a\u5e73\u5747\u666e\u901a\u80a1\u80a1\u6578\uff1a<\/span><\/p>\n<p>     <\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u2014\u57fa\u672c<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">54,533,161<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">54,604,787<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u2014\u7a00\u91cb\u5f8c<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">54,533,161<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">54,604,787<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u975e\u7f8e\u570b\u901a\u7528\u6703\u8a08\u6e96\u5247\u4e0b\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u6de8\u8667\u640d<\/span><\/p>\n<p>     <\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u2014\u57fa\u672c<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(0.77)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(0.00)<\/span><\/p>\n<p class=\"prnml10\"><span class=\"prnews_span\">\u2014\u7a00\u91cb\u5f8c<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(0.77)<\/span><\/p>\n<p>      <\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">(0.00)<\/span><\/p>\n<\/div>\n<p>\u00a0 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Corporation\uff09\u7684\u9996\u5e2d\u6230\u7565\u5b98\uff0c\u5176\u5728\u4f01\u696d\u6230\u7565\u3001\u6230\u7565\u5408\u4f5c\u53ca\u806f\u76df\u7ba1\u7406\u65b9\u9762\u64c1\u6709\u8457\u8c50\u5bcc\u7684\u7d93\u9a57\uff0c\u5c24\u5176\u5728\u50b3\u5947\u751f\u7269\uff08\u91d1\u65af\u745e\u7684\u5b50\u516c\u53f8\uff09\u548c\u8de8\u570b\u85e5\u4f01\u6230\u7565\u5408\u4f5c\u8ac7\u5224\u7684\u65e9\u671f\u968e\u6bb5\u767c\u63ee\u4e86\u95dc\u9375\u4f5c\u7528\u3002\u6b64\u5916\uff0c\u675c\u65b9\u52c7\u535a\u58eb\uff0c2020\u5e74\u8d77\u4efb\u5929\u6f14\u9996\u5e2d\u6280\u8853\u5b98\uff0c\u56e0\u500b\u4eba\u539f\u56e0\u9000\u51fa\u8463\u4e8b\u6703\u3002\u540c\u6642\uff0c\u516c\u53f8\u4efb\u547d\u5929\u6f14\u5275\u59cb\u5718\u968a\u6210\u54e1\uff0c\u751f\u7269\u4fe1\u606f\u79d1\u6280\u9ad8\u7d1a\u526f\u7e3d\u88c1\u674e\u8277\u64d4\u4efb\u8463\u4e8b\u4e00\u8077\u3002\u4eca\u5e74\u65e9\u4e9b\u6642\u5019\uff0c\u5929\u6f14\u516c\u4f48\u4e86\u8463\u4e8b\u6703\u7684\u6700\u65b0\u52d5\u614b\uff1aMervyn Turner\u535a\u58eb\uff0c\u9ed8\u6c99\u6771\u7814\u7a76\u5be6\u9a57\u5ba4\uff08Merck research Laboratories\uff09\u524d\u5168\u7403\u8a31\u53ef\u548c\u5916\u90e8\u7814\u7a76\u90e8\u9580\u8ca0\u8cac\u4eba\uff0c\u88ab\u4efb\u547d\u70ba\u8463\u4e8b\uff1b\u738b\u96e8\u6fdb\u63a5\u66ff\u5b6b\u6a02\u975e\u64d4\u4efb\u7531\u6cdb\u5927\u897f\u6d0b\u6295\u8cc7\u96c6\u5718\u65b0\u52a0\u5761\u8fa6\u4e8b\u8655\uff08General Atlantic Singapore AI Pte. Ltd\uff09\u6307\u5b9a\u7684\u8463\u4e8b\uff1b\u5289\u6bd3\u6587\u56e0\u9996\u6b21\u4efb\u671f\u5c46\u6eff\uff0c\u8fad\u53bb\u8463\u4e8b\u6703\u53ca\u5be9\u8a08\u59d4\u54e1\u6703\u6210\u54e1\u8077\u52d9\u3002 \u79d1\u5b78\u9867\u554f\u59d4\u54e1\u6703\uff1a\u4eca\u5e743\u6708\uff0c\u91ab\u5b78\u535a\u58ebAur\u00e9lien Marabelle\u6559\u6388\u88ab\u4efb\u547d\u70ba\u516c\u53f8\u79d1\u5b78\u9867\u554f\u59d4\u54e1\u6703\u6210\u54e1\u3002Marabelle\u6559\u6388\u662f\u6cd5\u570bGustave Roussy\u764c\u75c7\u4e2d\u5fc3\u85e5\u7269\u958b\u767c\u90e8\uff08DITEP\uff09\u7684\u91ab\u5b78\u79d1\u5b78\u5bb6\uff0c\u4e5f\u662f\u816b\u7624\u5b78\u548c\u514d\u75ab\u5b78\u9818\u57df\u7684\u5c08\u5bb6\u3002\u4ed6\u5728\u816b\u7624\u7279\u7570\u6027\u8abf\u7bc0\u6027T\u7d30\u80de\uff08Treg\uff09\u6e05\u9664\u65b9\u9762\u64c1\u6709\u6df1\u523b\u898b\u89e3\uff0c\u958b\u5275\u6027\u5730\u5f15\u5165\u816b\u7624\u5167\u800c\u975e\u7cfb\u7d71\u7d66\u85e5\u6297CTLA-4\u7642\u6cd5\uff0c\u5f9e\u800c\u514b\u670d\u6297CTLA-4\u7642\u6cd5\u5291\u91cf\u4f9d\u8cf4\u6027\u6bd2\u6027\u554f\u984c\u3002 \u8ca1\u52d9\u4eae\u9ede \u73fe\u91d1\u548c\u73fe\u91d1\u7b49\u50f9\u7269\u73fe\u91d1\u548c\u73fe\u91d1\u7b49\u50f9\u72692022\u5e7412\u670831\u65e5\u7d0414,380\u842c\u7f8e\u5143\uff0c2023\u5e746\u670830\u65e5\u7d0412,880\u842c\u7f8e\u5143\u3002 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\u6de8\u6536\u5165\u6de8\u6536\u5165\u540c\u6bd4\u589e\u9577\u4e86\u7d04341%\u3002\u6de8\u6536\u5165\u76f8\u8f03\u65bc2022\u5e74\u540c\u671f\u7684390\u842c\u7f8e\u5143\u589e\u52a0\u52302023\u5e746\u670830\u65e51,730\u842c\u7f8e\u5143\u3002\u8a72\u589e\u9577\u5305\u542b\u4e86\u56e0\u516c\u53f8\u5c65\u884c\u4e86\u8207\u8cfd\u8afe\u83f2\u548cExelixis\u6240\u5206\u5225\u7c3d\u8a02\u7684\u6280\u8853\u5408\u4f5c\u548c\u6388\u6b0a\u5354\u8b70\u4e2d\u7684\u5c65\u7d04\u7fa9\u52d9\u800c\u78ba\u8a8d\u7684\u6536\u5165\u3002\u6de8\u6536\u5165\u4e5f\u5305\u542b\u4e86\u65bc2023\u5e746\u6708\u5f9eExelixis\u6536\u5230\u7684300\u842c\u7f8e\u5143\u91cc\u7a0b\u7891\u4ed8\u6b3e\u3002 \u7814\u767c\u8cbb\u7528 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\u975e\u7f8e\u570b\u901a\u7528\u6703\u8a08\u6e96\u5247\uff08Non-GAAP\uff09\u4e0b\u7684\u8667\u640d\u975e\u7f8e\u570b\u901a\u7528\u6703\u8a08\u6e96\u5247\u4e0b\u7684\u6de8\u8667\u640d\u5b9a\u7fa9\u70ba\u8a72\u671f\u9593\u7684\u7f8e\u570b\u901a\u7528\u6703\u8a08\u6e96\u5247\u4e0b\u7684\u6de8\u8667\u640d\u5254\u9664\u80a1\u6b0a\u6fc0\u52f5\u8cbb\u7528\u3002\u8a72\u91d1\u984d\u5f9e2022\u5e74\u540c\u671f\u7684\u6de8\u8667\u640d4,190\u842c\u7f8e\u5143\uff0c\u4e0b\u964d\u81f32023\u5e746\u670830\u65e5\u768410\u842c\u7f8e\u5143\u3002\u8acb\u53c3\u95b1\u672c\u65b0\u805e\u7a3f\u4e2d\u984c\u70ba\u300c\u7f8e\u570b\u901a\u7528\u6703\u8a08\u6e96\u5247\uff08GAAP\uff09\u548c\u975e\u7f8e\u570b\u901a\u7528\u6703\u8a08\u6e96\u5247\uff08Non-GAAP\uff09\u4e0b\u7684\u696d\u7e3e\u8abf\u7bc0\u8868\u300d\u90e8\u5206\u77ad\u89e3\u8a73\u60c5\u3002 \u5929\u6f14\u85e5\u696d\u4f7f\u7528Non-GAAP\u6de8\u8667\u640d\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u6de8\u8667\u640d\uff0c\u7528\u65bc\u8a55\u4f30\u672c\u516c\u53f8\u7684\u7d93\u71df\u6210\u679c\uff0c\u4ee5\u53ca\u8ca1\u52d9\u548c\u7d93\u71df\u6c7a\u7b56\u3002\u672c\u516c\u53f8\u8a8d\u70ba\uff0cNon-GAAP\u6de8\u8667\u640d\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u6de8\u8667\u640d\u6709\u52a9\u65bc\u8b58\u5225\u672c\u516c\u53f8\u696d\u52d9\u7684\u57fa\u672c\u8da8\u52e2\uff0c\u800c\u9019\u4e9b\u8da8\u52e2\u53ef\u80fd\u56e0\u672c\u516c\u53f8\u8a08\u5165\u672c\u671f\u9593\u8667\u640d\u7684\u67d0\u4e9b\u8cbb\u7528\u7684\u5f71\u97ff\u800c\u626d\u66f2\u3002\u672c\u516c\u53f8\u8a8d\u70ba\uff0cNon-GAAP\u6de8\u8667\u640d\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u6de8\u8667\u640d\u63d0\u4f9b\u4e86\u6709\u95dc\u5176\u7d93\u71df\u6210\u679c\u7684\u6709\u7528\u4fe1\u606f\uff0c\u6574\u9ad4\u63d0\u5347\u4e86\u5c0d\u5176\u904e\u53bb\u696d\u7e3e\u548c\u672a\u4f86\u524d\u666f\u7684\u5168\u9762\u77ad\u89e3\uff0c\u4e26\u4f7f\u7ba1\u7406\u5c64\u5728\u8ca1\u52d9\u548c\u904b\u71df\u6c7a\u7b56\u4e2d\u4f7f\u7528\u7684\u95dc\u9375\u6307\u6a19\u66f4\u5177\u53ef\u898b\u6027\u3002 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\u8acb\u53c3\u95b1\u672c\u516c\u544a\u7d50\u5c3e\u7684\u300c\u7f8e\u570b\u901a\u7528\u6703\u8a08\u6e96\u5247\uff08GAAP\uff09\u548c\u975e\u7f8e\u570b\u901a\u7528\u6703\u8a08\u6e96\u5247\uff08Non-GAAP\uff09\u4e0b\u7684\u696d\u7e3e\u8abf\u7bc0\u8868\u300d\uff0c\u7372\u53d6\u672c\u671f\u9593Non-GAAP\u6de8\u8667\u640d\u548cNon-GAAP\u7684\u6bcf\u80a1\u666e\u901a\u80a1\u6de8\u8667\u640d\u7684\u5b8c\u6574\u7684\u8abf\u6574\u904e\u7a0b\u3002 \u95dc\u65bc\u5929\u6f14\u85e5\u696d 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\u5982\u9700\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\uff1a\u00a0https:\/\/investor.adagene.com\u00a0\u4e26\u95dc\u6ce8\u5929\u6f14\u85e5\u696d\u5fae\u4fe1\u3001\u9818\u82f1\u53ca\u63a8\u7279\u5b98\u65b9\u5e33\u865f\u3002 SAFEbody\u00ae \u70ba\u5929\u6f14\u5728\u7f8e\u570b\u3001\u4e2d\u570b\u3001\u6fb3\u5927\u5229\u4e9e\u3001\u65e5\u672c\u3001\u65b0\u52a0\u5761\u548c\u6b50\u76df\u7684\u8a3b\u518a\u5546\u6a19\u3002 \u5b89\u5168\u6e2f\u8072\u660e\u00a0 \u672c\u65b0\u805e\u7a3f\u5305\u542b\u524d\u77bb\u6027\u9673\u8ff0\uff0c\u5305\u62ec\u95dc\u65bc\u81e8\u5e8a\u6578\u64da\u5c0d\u60a3\u8005\u7684\u6f5b\u5728\u5f71\u97ff\u7684\u9673\u8ff0\uff0c\u4ee5\u53ca\u5929\u6f14\u85e5\u696d\u7684\u63a8\u9032\u548c\u9810\u671f\u7684\u81e8\u5e8a\u524d\u6d3b\u52d5\u3001\u81e8\u5e8a\u958b\u767c\u3001\u76e3\u7ba1\u91cc\u7a0b\u7891\u4ee5\u53ca\u5176\u5019\u9078\u7522\u54c1\u7684\u5546\u696d\u5316\u3002\u7531\u65bc\u5404\u7a2e\u91cd\u8981\u56e0\u7d20\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u65bc\u5929\u6f14\u85e5\u696d\u8b49\u660e\u5176\u5019\u9078\u85e5\u7269\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u80fd\u529b\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u8207\u524d\u77bb\u6027\u9673\u8ff0\u4e2d\u6240\u793a\u7684\u7d50\u679c\u5b58\u5728\u91cd\u5927\u5dee\u7570\uff1b\u5176\u5019\u9078\u85e5\u7269\u7684\u81e8\u5e8a\u7d50\u679c\uff0c\u53ef\u80fd\u4e0d\u652f\u6301\u9032\u4e00\u6b65\u958b\u767c\u6216\u76e3\u7ba1\u6279\u51c6\uff1b\u76f8\u95dc\u76e3\u7ba1\u6a5f\u69cb\u5c31\u5929\u6f14\u85e5\u696d\u5019\u9078\u85e5\u7269\u7684\u76e3\u7ba1\u6279\u51c6\u505a\u51fa\u6c7a\u5b9a\u7684\u5167\u5bb9\u548c\u6642\u9593\uff1b\u5982\u679c\u7372\u5f97\u6279\u51c6\uff0c\u5929\u6f14\u85e5\u696d\u70ba\u5176\u5019\u9078\u85e5\u7269\u53d6\u5f97\u5546\u696d\u6210\u529f\u7684\u80fd\u529b\uff1b\u5929\u6f14\u85e5\u696d\u70ba\u5176\u6280\u8853\u548c\u85e5\u7269\u7372\u5f97\u548c\u7dad\u6301\u77e5\u8b58\u7522\u6b0a\u4fdd\u8b77\u7684\u80fd\u529b\uff1b\u5929\u6f14\u85e5\u696d\u4f9d\u8cf4\u7b2c\u4e09\u65b9\u9032\u884c\u85e5\u7269\u958b\u767c\u3001\u88fd\u9020\u548c\u5176\u4ed6\u670d\u52d9\uff1b\u5929\u6f14\u85e5\u696d\u6709\u9650\u7684\u7d93\u71df\u6b77\u53f2\u4ee5\u53ca\u5929\u6f14\u85e5\u696d\u7372\u5f97\u984d\u5916\u904b\u71df\u8cc7\u91d1\u4ee5\u53ca\u5b8c\u6210\u5176\u5019\u9078\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u7684\u80fd\u529b\uff1b\u5929\u6f14\u85e5\u696d\u5728\u5176\u73fe\u6709\u6230\u7565\u5925\u4f34\u95dc\u4fc2\u6216\u5408\u4f5c\u4e4b\u5916\u7c3d\u8a02\u984d\u5916\u5408\u4f5c\u5354\u8b70\u7684\u80fd\u529b\uff0c\u4ee5\u53caCOVID-19 \u6d41\u884c\u5c0d\u5929\u6f14\u85e5\u696d\u81e8\u5e8a\u958b\u767c\u3001\u5546\u696d\u548c\u5176\u4ed6\u904b\u71df\u7684\u5f71\u97ff\uff0c\u4ee5\u53ca\u5728\u5929\u6f14\u63d0\u4ea4\u7d66\u7f8e\u570b\u8b49\u5238\u4ea4\u6613\u59d4\u54e1\u6703\u768420-F\u5f62\u5f0f\u76842022\u5e74\u7684\u5e74\u5ea6\u5831\u544a\u4e2d\u300c\u98a8\u96aa\u56e0\u7d20\u300d\u90e8\u5206\u66f4\u5145\u5206\u8a0e\u8ad6\u7684\u90a3\u4e9b\u98a8\u96aa\u3002\u6240\u6709\u524d\u77bb\u6027\u9673\u8ff0\u5747\u57fa\u65bc\u5929\u6f14\u85e5\u696d\u7576\u524d\u53ef\u7372\u5f97\u7684\u4fe1\u606f\uff0c\u9664\u975e\u4f9d\u7167\u6cd5\u5f8b\u4e4b\u53ef\u80fd\u8981\u6c42\uff0c\u5929\u6f14\u85e5\u696d\u4e0d\u627f\u64d4\u56e0\u65b0\u4fe1\u606f\u3001\u672a\u4f86\u4e8b\u4ef6\u6216\u5176\u4ed6\u539f\u56e0\u800c\u516c\u958b\u66f4\u65b0\u6216\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9673\u8ff0\u7684\u7fa9\u52d9\u3002 \u00a0 \u00a0 \u8ca1\u52d9\u5831\u8868 \u672a\u7d93\u5be9\u8a08\u7684\u5408\u4f75\u8cc7\u7522\u8ca0\u50b5\u8868\uff08\u7f8e\u570b\u901a\u7528\u6703\u8a08\u6e96\u5247\uff09 \u622a\u6b62\u81f32022\u5e7412\u670831\u65e5 \u622a\u6b62\u81f32023\u5e746\u670830\u65e5 US$ US$ \u8cc7\u7522 \u6d41\u52d5\u8cc7\u7522: \u73fe\u91d1\u53ca\u73fe\u91d1\u7b49\u50f9\u7269 143,758,678 128,759,962 \u61c9\u6536\u95dc\u806f\u65b9\u6b3e\u9805 619,432 393,969 \u5176\u4ed6\u6d41\u52d5\u8cc7\u7522\u548c\u9810\u4ed8\u8cec\u6b3e 4,937,323 3,524,688 \u6d41\u52d5\u8cc7\u7522\u7e3d\u984d 149,315,433 132,678,619 \u56fa\u5b9a\u8cc7\u7522 2,782,963 2,222,200 \u4f7f\u7528\u6b0a\u8cc7\u7522 191,877 292,523 \u5176\u4ed6\u975e\u6d41\u52d5\u8cc7\u7522 109,572 108,922 \u8cc7\u7522\u7e3d\u984d 152,399,845 135,302,264 \u00a0 \u8ca0\u50b5\u548c\u80a1\u6771\u6b0a\u76ca \u6d41\u52d5\u8ca0\u50b5: \u61c9\u4ed8\u8cec\u6b3e 3,666,124 4,483,776 \u5408\u540c\u8ca0\u50b5 15,107,276 812,916 \u61c9\u4ed8\u95dc\u806f\u65b9\u6b3e\u9805 19,323,337 17,216,032 \u9810\u63d0\u53ca\u5176\u4ed6\u6d41\u52d5\u8ca0\u50b5 3,212,809 2,834,565 \u61c9\u4ed8\u6240\u5f97\u7a05 \u2014 1,895,063 \u77ed\u671f\u501f\u6b3e 10,768,745 8,995,544 \u4e00\u5e74\u5167\u5230\u671f\u7684\u9577\u671f\u501f\u6b3e 2,850,128 2,594,868 \u4e00\u5e74\u5167\u5230\u671f\u7684\u79df\u8cc3\u8ca0\u50b5 151,983 158,859 \u6d41\u52d5\u8ca0\u50b5\u7e3d\u984d 55,080,402 38,991,623 \u9577\u671f\u501f\u6b3e 14,146,541 13,348,003 \u79df\u8cc3\u8ca0\u50b5 53,834 141,431 \u5176\u4ed6\u975e\u6d41\u52d5\u8ca0\u50b5 28,718 27,679 \u8ca0\u50b5\u7e3d\u984d 69,309,495 52,508,736 \u00a0 \u80a1\u6771\u6b0a\u76ca: \u80a1\u672c 5,497 5,556 \u5eab\u5b58\u80a1 (4) (4) \u8cc7\u672c\u516c\u7a4d 342,739,268 346,958,523 \u5176\u4ed6\u7d9c\u5408\u8667\u640d (849,305) (1,256,635) \u7d2f\u8a08\u8667\u640d (258,805,106) (262,913,912) \u80a1\u6771\u6b0a\u76ca\u7e3d\u984d 83,090,350 82,793,528 \u8ca0\u50b5\u548c\u80a1\u6771\u6b0a\u76ca\u7e3d\u984d 152,399,845 135,302,264 \u00a0 \u00a0 \u672a\u7d93\u5be9\u8a08\u7684\u5408\u4f75\u5229\u6f64\u8868 \uff08\u7f8e\u570b\u901a\u7528\u6703\u8a08\u6e96\u5247\uff09 \u622a\u81f36\u670830\u65e5\u76846\u500b\u6708 2022 2023 \u6536\u5165 \u6280\u8853\u8a31\u53ef\u5408\u4f5c\u6536\u5165 3,923,174 17,295,745 \u8cbb\u7528 \u7814\u767c\u8cbb\u7528 (45,148,357) (21,289,434) \u7ba1\u7406\u8cbb\u7528 (6,848,925) (4,470,520) \u8cbb\u7528\u7e3d\u984d (51,997,282) (25,759,954) \u5176\u4ed6\u71df\u696d\u6536\u5165 \u2014 3,415,230 \u71df\u696d\u8667\u640d (48,074,108) (5,048,979) \u5229\u606f\u6536\u5165 14,931 1,918,971 \u5229\u606f\u8cbb\u7528 (211,434) (573,507) \u5176\u4ed6\u6536\u5165 430,671 3,702,660 \u532f\u514c\u640d\u76ca &#8230; <\/p>\n<p class=\"read-more-container\"><a title=\"\u5929\u6f14\u85e5\u696d\uff08Adagene Inc., NASDAQ\uff1aADAG\uff09\u516c\u4f482023\u5e74\u4e0a\u534a\u5e74\u8ca1\u52d9\u696d\u7e3e\u53ca\u516c\u53f8\u9032\u5c55\" class=\"read-more button\" 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