{"id":13212,"date":"2023-06-27T00:30:00","date_gmt":"2023-06-26T16:30:00","guid":{"rendered":"https:\/\/www.franchise.com.hk\/%e4%be%86%e6%81%a9%e7%94%9f%e7%89%a9%e5%ae%a3%e4%bd%88%e5%ae%8c%e6%88%90%e8%b6%853%e5%84%84%e5%85%83b2%e8%bc%aa%e8%9e%8d%e8%b3%87%ef%bc%8c%e5%85%a8%e7%90%83%e9%a0%98%e8%b7%91mrna%e7%b7%a8%e7%a2%bc\/13212"},"modified":"2023-06-27T00:30:00","modified_gmt":"2023-06-26T16:30:00","slug":"%e4%be%86%e6%81%a9%e7%94%9f%e7%89%a9%e5%ae%a3%e4%bd%88%e5%ae%8c%e6%88%90%e8%b6%853%e5%84%84%e5%85%83b2%e8%bc%aa%e8%9e%8d%e8%b3%87%ef%bc%8c%e5%85%a8%e7%90%83%e9%a0%98%e8%b7%91mrna%e7%b7%a8%e7%a2%bc","status":"publish","type":"post","link":"https:\/\/www.franchise.com.hk\/en\/%e4%be%86%e6%81%a9%e7%94%9f%e7%89%a9%e5%ae%a3%e4%bd%88%e5%ae%8c%e6%88%90%e8%b6%853%e5%84%84%e5%85%83b2%e8%bc%aa%e8%9e%8d%e8%b3%87%ef%bc%8c%e5%85%a8%e7%90%83%e9%a0%98%e8%b7%91mrna%e7%b7%a8%e7%a2%bc\/13212","title":{"rendered":"\u4f86\u6069\u751f\u7269\u5ba3\u4f48\u5b8c\u6210\u8d853\u5104\u5143B2\u8f2a\u878d\u8cc7\uff0c\u5168\u7403\u9818\u8dd1mRNA\u7de8\u78bc\u7684TCR-T\u7d30\u80de\u6cbb\u7642\u5be6\u9ad4\u7624"},"content":{"rendered":"

\u65b0\u52a0\u5761\u548c\u4e2d\u570b\u5ee3\u5dde<\/span>2023\u5e746\u670827\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — 2023\u5e746\u670827\u65e5\uff0c\u4f86\u6069\u751f\u7269\uff08Lion TCR\uff09\u5ba3\u4f48\u5b8c\u6210\u8d853\u5104\u5143B2\u8f2a\u878d\u8cc7\uff0c\u7531\u5ee3\u5dde\u7522\u6295\u9818\u6295\u3001\u5ee3\u5dde\u9ad8\u65b0\u5340\u96c6\u5718\u76f4\u5c6c\u4f01\u696d\u570b\u805a\u5275\u6295\u8207\u77f3\u85e5\u7d0d\u5fb7\u57fa\u91d1\u5171\u540c\u5b8c\u6210\u3002\u878d\u8cc7\u8cc7\u91d1\u5c07\u4e3b\u8981\u7528\u65bc\u652f\u6301\u4f86\u6069\u751f\u7269\u81e8\u5e8a\u8a66\u9a57\u7684\u63a8\u9032\u3001\u5ee3\u5ddeGMP\u7d30\u80de\u8eca\u9593\u7684\u5efa\u8a2d\u4ee5\u53ca\u7814\u767c\u7ba1\u7dda\u7684\u62d3\u5c55\u7b49\u3002 2023\u5e746\u670826\u65e5\uff0c\u5728\u65b0\u52a0\u5761\u885b\u751f\u90e8\u90e8\u9577\u738b\u4e59\u5eb7\u5148\u751f\u548c\u5ee3\u6771\u7701\u7701\u9577\u738b\u5049\u4e2d\u5148\u751f\u7684\u5171\u540c\u898b\u8b49\u4e0b\uff0c\u4f86\u6069\u751f\u7269\u8207\u5ee3\u5dde\u7522\u6295\u3001\u570b\u805a\u5275\u6295\u3001\u77f3\u85e5\u7d0d\u5fb7\u57fa\u91d1\u5728\u65b0\u52a0\u5761-\u5ee3\u6771\u5408\u4f5c\u7406\u4e8b\u6703\u7b2c\u5341\u4e09\u6b21\u6703\u8b70\u4e0a\u9032\u884c\u4e86\u6b64\u6b21\u878d\u8cc7\u6295\u8cc7\u5354\u8b70\u7684\u7c3d\u7d04\u3002<\/p>\n

\n

<\/a>
\u4f86\u6069\u751f\u7269\u5728\u5ee3\u6771-\u65b0\u52a0\u5761\u5408\u4f5c\u7406\u4e8b\u6703\u7b2c\u5341\u4e09\u6b21\u6703\u8b70\u4e0a\u7c3d\u7d04<\/span><\/p>\n<\/div>\n

\u4f86\u6069<\/span>\u751f\u7269\u76ee\u524d\u5df2\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u8207\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6388\u4e88\u7684\u570b\u969b\u591a\u4e2d\u5fc3Ib\/II\u671f\u7684IND\u81e8\u5e8a\u6279\u4ef6\uff0c\u9019\u662f\u5168\u7403\u7b2c\u4e00\u500b\u7d93FDA\u6279\u51c6\uff0c\u5229\u7528TCR-T\u7d30\u80de\u6cbb\u7642\u4e59\u809d\u76f8\u95dc\u809d\u7d30\u80de\u764c\u7684\u570b\u969b\u591a\u4e2d\u5fc3\u81e8\u5e8a\u8a66\u9a57\uff0c\u76ee\u524d\u5df2\u5b8c\u6210\u591a\u4f8b\u60a3\u8005\u56de\u8f38\uff0c\u6b64TCR-T\u7d30\u80de\u7642\u6cd5\u9084\u7372\u5f97\u4e86FDA\u6388\u4e88\u7684\u5feb\u901f\u901a\u9053\u8a8d\u5b9a\uff08Fast Track\uff09\u548c\u5b64\u5152\u85e5\uff08Orphan Drug\uff09\u8cc7\u683c\u3002<\/p>\n

\u4f86\u6069\u751f\u7269\u65bc2015\u5e74\u5f9e\u65b0\u52a0\u5761\u79d1\u6280\u7814\u7a76\u5c40\uff08A*STAR\uff09\u5b75\u5316\u800c\u51fa\uff0c\u9996\u6b3e\u7522\u54c1\u70baFirst-in-Class HBV\u7279\u7570\u6027TCR-T\u7d30\u80de\u7642\u6cd5\uff0c\u4e26\u901a\u904emRNA\u6280\u8853\u7de8\u78bcTCR\uff0c\u7528\u65bc\u6cbb\u7642\u809d\u7d30\u80de\u764c\uff0c\u5df2\u7d93\u5c55\u73fe\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u986f\u8457\u7642\u6548\u3002\u76ee\u524d\uff0c\u4f86\u6069\u751f\u7269\u5df2\u7d93\u5efa\u7acb\u4e86TCR\u767c\u73fe\u5e73\u53f0\u8207mRNA\u6280\u8853\u5e73\u53f0\uff0c\u5728\u9019\u5169\u500b\u5e73\u53f0\u57fa\u790e\u4e0a\u62d3\u5c55\u7522\u54c1\u7ba1\u7dda\uff0c\u901a\u904e\u9776\u5411\u4e0d\u540c\u9776\u9ede\u6cbb\u7642\u591a\u7a2e\u5be6\u9ad4\u7624\u3002\u4f86\u6069\u751f\u7269\u4f48\u5c40\u4e86\u5f9e\u81ea\u9ad4\u7d30\u80de\u7642\u6cd5\u5230\u73fe\u8ca8\u578b\u7642\u6cd5\u7522\u54c1\uff0c\u4ee5\u63d0\u9ad8\u60a3\u8005\u7684\u53ef\u53ca\u6027\uff0c\u70ba\u5c1a\u672a\u89e3\u6c7a\u7684\u81e8\u5e8a\u9700\u6c42\u63d0\u4f9b\u5275\u65b0\u7642\u6cd5\u3002<\/p>\n

\u5c0d\u65bc\u672c\u8f2a\u878d\u8cc7\uff0c\u4f86\u6069\u751f\u7269\u9996\u5e2d\u57f7\u884c\u5b98\u5f6d\u66c9\u660e\u535a\u58eb\u8868\u793a\uff1a<\/span>\u300c\u6b64\u6b21\u878d\u8cc7\u6210\u529f\u5c07\u52a9\u529b\u4f86\u6069\u751f\u7269\u6309\u7167\u5df2\u5efa\u7acb\u7684\u6280\u8853\u5e73\u53f0\u767c\u5c55\u6230\u7565\u5feb\u901f\u7a69\u6b65\u63a8\u9032\u7522\u54c1\u7ba1\u7dda\u3002 \u540c\u6642\u4e5f\u6709\u52a9\u65bc\u4f86\u6069\u751f\u7269\u9032\u4e00\u6b65\u4f9d\u6258\u4e2d\u65b0\u5408\u4f5c\u7684\u570b\u969b\u5e73\u53f0\u5927\u529b\u767c\u5c55\u79d1\u6280\u5275\u65b0\uff0c\u651c\u624b\u5ee3\u5dde\u7522\u6295\u3001\u5ee3\u5dde\u9ad8\u65b0\u5340\u96c6\u5718\u53ca\u77f3\u85e5\u96c6\u5718\u5728\u65b0\u52a0\u5761\u548c\u5927\u7063\u5340\u69cb\u7bc9\u570b\u969b\u751f\u7269\u79d1\u6280\u751f\u614b\u5708\uff0c\u5efa\u8a2d\u7d30\u80de\u6cbb\u7642\u9818\u57df\u7684\u793a\u7bc4\u55ae\u4f4d\uff0c\u9020\u798f\u60a3\u8005\uff0c\u56de\u994b\u793e\u6703\u3002\u300d<\/p>\n

\u4f86\u6069\u751f\u7269\u65bc2022\u5e746\u6708\u548c\u5ee3\u5dde\u5e02\u9ec3\u57d4\u5340\u653f\u5e9c\u5728\u751f\u7269\u7522\u696d\u5927\u6703\u4e0a\u6b63\u5f0f\u7c3d\u7d04\uff0c\u5c07\u4e2d\u570b\u7e3d\u90e8\u843d\u5730\u5ee3\u5dde\u4e2d\u65b0\u77e5\u8b58\u57ce\uff0c\u62d3\u5c55\u570b\u969b\u767c\u5c55\u7a7a\u9593\u3002\u5f6d\u66c9\u660e\u535a\u58eb\u9032\u4e00\u6b65\u4ecb\u7d39\uff0c\u300c\u5ee3\u5dde\u64c1\u6709\u4e2d\u570b\u9802\u5c16\u7684\u7684\u91ab\u9662\u8cc7\u6e90\uff0c\u653f\u5e9c\u4e5f\u7d66\u4e88\u91ab\u85e5\u4f01\u696d\u5f88\u591a\u653f\u7b56\u548c\u8cc7\u91d1\u652f\u6301\uff0c\u6211\u5011\u770b\u5230\u4e86\u5ee3\u5dde\u751f\u7269\u91ab\u85e5\u7522\u696d\u767c\u5c55\u7684\u6c7a\u5fc3\u548c\u53cb\u597d\u7684\u751f\u614b\u74b0\u5883\uff0c\u6240\u4ee5\u6c7a\u5b9a\u5c07\u4e2d\u570b\u7e3d\u90e8\u653e\u5728\u5ee3\u5dde\uff0c\u9019\u5c07\u662f\u96c6\u7ba1\u7dda\u7814\u767c\u3001GMP\u751f\u7522\u548c\u81e8\u5e8a\u8a3b\u518a\u65bc\u4e00\u9ad4\u7684\u7d9c\u5408\u57fa\u5730\u3002\u4e2d\u570b\u7e3d\u90e8\u7d9c\u5408\u57fa\u5730\u4f54\u5730\u7e3d\u9762\u7a4d\u8d85\u904e5000\u5e73\u7c73\uff0c\u843d\u6210\u5f8c\u5c07\u5f62\u6210\u9589\u74b0\u7684\u7b26\u5408GMP\u6a19\u6e96\u7684\u7d30\u80de\u7522\u54c1\u751f\u7522\u3001\u653e\u884c\u3001\u51b7\u93c8\u904b\u8f38\u3001\u60a3\u8005\u56de\u8f38\u7b49\u7aef\u5230\u7aef\u904b\u71df\u80fd\u529b\uff0c\u670d\u52d9\u4e2d\u570b\u60a3\u8005\u3002\u300d<\/p>\n

\n

<\/a>
\u4f86\u6069\u751f\u7269\u4e2d\u570b\u7e3d\u90e8\u5ee3\u5dde\u570b\u969b\u751f\u7269\u91ab\u85e5\u5275\u65b0\u4e2d\u5fc3<\/span><\/p>\n<\/div>\n

\u00a0<\/p>\n

\n

<\/a>
\u4f86\u6069\u751f\u7269\u4e2d\u570b\u7e3d\u90e8\u5ee3\u5dde\u4e2d\u65b0\u667a\u6167\u5712<\/span><\/p>\n<\/div>\n

\u5c0d\u65bc\u672c\u6b21\u6295\u8cc7\uff0c\u9664\u4e86\u8003\u616e\u5230\u4f86\u6069\u751f\u7269\u81ea\u8eab\u5728\u6280\u8853\u65b9\u9762\u7684\u904e\u786c\u5be6\u529b\u5916\uff0c\u6295\u8cc7\u65b9\u4e5f\u5404\u6709\u8003\u91cf\u3002<\/p>\n

\u5ee3\u5dde\u7522\u6295\u7684\u6295\u8cc7\u901a\u5e38\u6709\u4e09\u500b\u5927\u65b9\u5411\uff0c\u4e00\u662f\u6295\u8cc7\u5ee3\u5dde\uff0c\u4ee5\u6295\u4fc3\u5f15\u63a8\u52d5\u91cd\u5927\u9805\u76ee\u843d\u5730\u3002\u4e8c\u662f\u6295\u8cc7\u5be6\u9ad4\uff0c\u4ee5\u6295\u4fc3\u7522\u63a8\u9032\u7522\u696d\u8f49\u578b\u5347\u7d1a\u3002\u4e09\u662f\u6295\u8cc7\u672a\u4f86\uff0c\u4ee5\u6295\u4fc3\u5275\u6436\u4f54\u672a\u4f86\u524d\u6cbf\u9663\u5730\u3002\u5ee3\u5dde\u7522\u6295\u96c6\u5718\u7e3d\u6703\u8a08\u5e2b\u90dd\u5fc5\u50b3\u6307\u51fa\uff1a \u5ee3\u5dde\u7522\u6295\u96c6\u5718\u5728\u751f\u7269\u91ab\u85e5\u8207\u5065\u5eb7\u7522\u696d\u9818\u57df\u5df2\u7d2f\u8a08\u6295\u8cc7\u8d8514\u5104\u5143\uff0c\u767c\u63ee\u7522\u696d\u8cc7\u672c\u5f15\u9818\u4f5c\u7528\uff0c\u767c\u6398\u884c\u696d\u9f8d\u982d\u4f01\u696d\u7cbe\u6e96\u300c\u704c\u6e89\u300d\uff0c\u70ba\u5ee3\u5dde\u751f\u7269\u91ab\u85e5\u8207\u5065\u5eb7\u7522\u696d\u88dc\u93c8\u5f37\u93c8\u3002\u6b64\u6b21\u5c0d\u4f86\u6069\u751f\u7269\u7684\u6295\u8cc7\uff0c\u662f\u5ee3\u5dde\u5e02\u5728\u5275\u65b0\u5347\u7d1a\u6a5f\u9047\u4e2d\u7684\u6838\u5fc3\u9700\u6c42\uff0c\u5ee3\u5dde\u7522\u6295\u96c6\u5718\u901a\u904e\u6a39\u7acb\u300c\u6295\u8cc7\u5728\u4eca\u5929\u3001\u529f\u6548\u5728\u672a\u4f86\u300d\u7684\u767c\u5c55\u7406\u5ff5\uff0c\u4ee5\u300c\u8010\u5fc3\u8cc7\u672c\u300d\u5168\u9031\u671f\u966a\u4f34\u7684\u9577\u671f\u601d\u7dad\u70ba\u7522\u696d\u6295\u8cc7\u9805\u76ee\u63d0\u4f9b\u8cc7\u91d1\u3001\u8cc7\u6e90\u3001\u670d\u52d9\u7b49\u7684\u300c\u4e00\u652c\u5b50\u300d\u89e3\u6c7a\u65b9\u6848\uff0c\u63a8\u52d5\u5ee3\u5dde\u7522\u696d\u9ad8\u8cea\u91cf\u767c\u5c55\u3002<\/p>\n

\u570b\u805a\u5275\u6295\u66f4\u591a\u7684\u662f\u5e0c\u671b\u548c\u4f86\u6069\u751f\u7269\u7684\u5408\u4f5c\u80fd\u5920\u5e36\u52d5\u52a0\u901f\u5ee3\u5dde\u5e02\u9ec3\u57d4\u5340\u7684\u751f\u7269\u91ab\u85e5\u767c\u5c55\u3002\u570b\u805a\u5275\u6295\u7684\u8463\u4e8b\u9577\u694a\u66e6\u8868\u793a\uff1a \u4f86\u6069\u751f\u7269\u64c1\u6709\u539f\u5275\u7684\u9776\u9ede\u6280\u8853\u53ca\u5b8c\u5584\u7684\u77e5\u8b58\u7522\u6b0a\uff0c\u5275\u65b0\u7684mRNA\u7de8\u78bc\u7684TCR-T\u5e73\u53f0\u6280\u8853\u53ef\u6301\u7e8c\u62d3\u5c55\u81f3\u591a\u7a2e\u5be6\u9ad4\u7624\uff0c\u4f86\u6069\u751f\u7269\u7684\u52a0\u5165\u5c07\u52a9\u529b\u9ec3\u57d4\u5340\u63a8\u9032\u751f\u7269\u91ab\u85e5\u7522\u696d\u767c\u5c55\uff0c\u5e36\u52d5\u9ad8\u65b0\u751f\u7269\u7522\u696d\u96c6\u7fa4\u7684\u6210\u9577\uff0c\u63d0\u5347\u5ee3\u5dde\u5e02\u4e43\u81f3\u5927\u7063\u5340\u751f\u7269\u91ab\u85e5\u5275\u65b0\u80fd\u7d1a\u3002<\/p>\n

\u77f3\u85e5\u7d0d\u5fb7\u57fa\u91d1\u5247\u662f\u770b\u6e96\u4e86\u4f86\u6069\u751f\u7269\u5728\u884c\u696d\u5167\u9818\u5148\u7684\u6280\u8853\u5be6\u529b\u548c\u767c\u5c55\u524d\u666f\uff0c\u4ee5\u53ca\u5408\u4f5c\u53ef\u80fd\u7d66\u96d9\u65b9\u5e36\u4f86\u7684\u5de8\u5927\u597d\u8655\u3002\u77f3\u85e5\u7d0d\u5fb7\u57fa\u91d1\u7ba1\u7406\u5408\u5925\u4eba\u5b6b\u805a\u6c11\u8868\u793a\uff1a\u300c<\/span>\u4f86\u6069\u751f\u7269\u7684\u539f\u5275\u79d1\u7814\u5be6\u529b\uff0c\u570b\u969b\u5316\u7684\u5718\u968a\u80cc\u666f\uff0c\u5c08\u6ce8\u5728\u539f\u5275\u79d1\u6280\u7684\u63a2\u7d22\u4ee5\u53ca\u5728mRNA\u548cTCR-T\u8cfd\u9053\u4e0a\u7684\u6df1\u8015\u5438\u5f15\u4e86\u6211\u5011\u7684\u6ce8\u610f\u3002\u77f3\u85e5\u96c6\u5718\u662f\u4e2d\u570b\u552f\u4e00\u4e00\u5bb6\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u6279\u51c6\u7dca\u6025\u4f7f\u7528\u7684mRNA\u65b0\u51a0\u75ab\u82d7\u4f01\u696d\uff0c\u5728\u884c\u696d\u4e2d\u8eab\u7d93\u767e\u6230\uff0c\u5728\u81e8\u5e8a\u7814\u7a76\u3001\u5e02\u5834\u63a8\u5ee3\u7b49\u5404\u500b\u74b0\u7bc0\u64c1\u6709\u8c50\u5bcc\u7684\u8cc7\u6e90\u3002\u6b64\u6b21\u6295\u8cc7\u4f86\u6069\u751f\u7269\uff0c\u5e0c\u671b\u9032\u4e00\u6b65\u63a8\u9032\u4f86\u6069\u751f\u7269\u548c\u77f3\u85e5\u96c6\u5718\u5728\u4ee5mRNA\u70ba\u57fa\u790e\u7684\u591a\u7a2e\u6210\u85e5\u65b9\u5f0f\u4e0a\u5171\u540c\u63a2\u7d22\u5408\u4f5c\uff0c\u82e5\u5728\u6210\u85e5\u6027\u4e0a\u5f97\u5230\u62d3\u5c55\u53ca\u7a81\u7834\uff0c\u5c07\u4f86\u6709\u671b\u5728\u81e8\u5e8a\u548c\u5546\u696d\u5316\u7b49\u65b9\u9762\u501f\u52a9\u96d9\u65b9\u8cc7\u6e90\u5f62\u6210\u96d9\u8d0f\u7684\u5c40\u9762\u3002\u300d<\/p>\n

\u95dc\u65bc\u5ee3\u5dde\u7522\u6295<\/p>\n

\u5ee3\u5dde\u7522\u696d\u6295\u8cc7\u63a7\u80a1\u96c6\u5718\u6709\u9650\u516c\u53f8\uff08\u7c21\u7a31\u300c\u5ee3\u5dde\u7522\u6295\u96c6\u5718\u300d\uff09<\/p>\n

\u5ee3\u5dde\u7522\u6295\u96c6\u5718\u5805\u6301\u300c\u6295\u8cc7\u5ee3\u5dde\u3001\u6295\u8cc7\u5be6\u9ad4\u3001\u6295\u8cc7\u672a\u4f86\u300d\u7406\u5ff5\uff0c\u6a39\u7acb\u300c\u8010\u5fc3\u8cc7\u672c\u300d\u7684\u7522\u696d\u767c\u5c55\u601d\u7dad\uff0c\u7acb\u8db3\u6230\u7565\u6295\u8cc7\u767c\u5c55\u5e73\u53f0\u3001\u570b\u6709\u80a1\u6b0a\u6301\u80a1\u5e73\u53f0\u3001\u8cc7\u672c\u904b\u4f5c\u7ba1\u7406\u5e73\u53f0\u4e09\u5927\u529f\u80fd\u5b9a\u4f4d\uff0c\u7a4d\u6975\u64d4\u7576\u7522\u696d\u6295\u884c\u548c\u8cc7\u672c\u904b\u71df\u5169\u5927\u89d2\u8272\uff0c\u63a7\u53c3\u80a1\u5ee3\u6c7d\u96c6\u5718\u3001\u5ee3\u85e5\u96c6\u5718\u3001\u5ee3\u5dde\u767c\u5c55\u3001\u73e0\u6c5f\u5564\u9152\u3001\u5ee3\u5dde\u9152\u5bb6\u3001\u73e0\u6c5f\u92fc\u7434\u3001\u5dba\u5357\u63a7\u80a1\u3001\u4e2d\u570b\u96fb\u5efa\u3001\u5b5a\u80fd\u79d1\u6280\u3001\u5730\u9435\u8a2d\u8a08\u9662\u7b4910\u591a\u5bb6\u4e0a\u5e02\u516c\u53f8\u4ee5\u53ca\u8d8a\u79c0\u96c6\u5718\u3001\u570b\u65b0\u8b49\u5238\u3001\u7d2b\u5149\u96c6\u5718\u3001\u7cb5\u82af\u534a\u5c0e\u9ad4\u3001\u4e2d\u79d1\u5b87\u822a\u7b49\u4e00\u6279\u9f8d\u982d\u4f01\u696d\uff0c\u727d\u982d\u7d44\u5efa\u4e26\u904b\u4f5c\u5be6\u65bd1500\u5104\u5143\u5ee3\u5dde\u7522\u696d\u6295\u8cc7\u6bcd\u57fa\u91d1\u548c500\u5104\u5143\u5ee3\u5dde\u5275\u65b0\u6295\u8cc7\u6bcd\u57fa\u91d1\u3002\u96c6\u5718\u64c1\u67094\u5bb6\u57fa\u91d1\u7ba1\u7406\u516c\u53f8\uff0c\u6295\u8cc7\u8a2d\u7acb\u4e26\u8207\u982d\u90e8\u6a5f\u69cb\u5408\u4f5c\u8a2d\u7acb\u57fa\u91d150\u591a\u652f\uff0c\u63d0\u4f9b\u5168\u93c8\u689d\u57fa\u91d1\u6295\u8cc7\u670d\u52d9\uff0c\u5df2\u5f62\u6210\u300c\u57fa\u91d1\u7ba1\u7406+\u7522\u696d\u6295\u8cc7+\u8cc7\u672c\u904b\u71df+\u5712\u5340\u670d\u52d9+\u79d1\u6280\u670d\u52d9\u300d\u7684\u696d\u52d9\u9ad4\u7cfb\u548c\u300c\u4e0a\u5e02\u516c\u53f8\u96c6\u7fa4+\u529f\u80fd\u5e73\u53f0\u96c6\u7fa4+\u7522\u696d\u767c\u5c55\u57fa\u91d1\u7fa4+\u5275\u65b0\u50f9\u503c\u5712\u5340\u300d\u7684\u904b\u4f5c\u67b6\u69cb\uff0c\u9023\u7e8c\u4e94\u5e74\u8e8b\u8eab\u300c\u4e2d\u570b\u4f01\u696d500\u5f37\u300d\u548c\u300c\u4e2d\u570b\u670d\u52d9\u696d\u4f01\u696d500\u5f37\u300d\uff0c\u5168\u529b\u6253\u9020\u5e02\u5834\u5316\u3001\u5c08\u696d\u5316\u3001\u570b\u969b\u5316\u7684\u4e00\u6d41\u570b\u6709\u8cc7\u672c\u6295\u8cc7\u904b\u71df\u5e73\u53f0\u3002<\/span><\/p>\n

\u95dc\u65bc\u570b\u805a\u5275\u6295<\/p>\n

\u570b\u805a\u5275\u6295\u662f\u5ee3\u5dde\u9ad8\u65b0\u5340\u96c6\u5718\u5168\u8cc7\u79c1\u52df\u80a1\u6b0a\u57fa\u91d1\u5b50\u516c\u53f8\uff0c\u7ba1\u7406\u53ca\u53c3\u8207\u7684\u57fa\u91d1\u898f\u6a21\u903e30\u5104\u5143\u3002\u901a\u904e\u300c\u751f\u7269\u91ab\u85e5\u7522\u696d\u57fa\u91d1\u300d\u767c\u63ee\u7684\u8cc7\u91d1\u5f15\u9818\u653e\u5927\u6548\u7528\uff0c\u53c3\u8207\u8a2d\u7acb\u4e86\u300c\u4e2d\u4ee5\u4e8c\u671f\u57fa\u91d1\u300d\u3001\u300c\u5ee3\u6771\u4e2d\u91ab\u85e5\u5927\u5065\u5eb7\u57fa\u91d1\u300d\uff0c\u9678\u7e8c\u8207\u7d93\u7def\u4e2d\u570b\u3001\u677e\u79be\u8cc7\u672c\u3001\u5143\u79be\u539f\u9ede\u7b49\u77e5\u540d\u6295\u8cc7\u6a5f\u69cb\u9054\u6210\u5408\u4f5c\uff0c\u81f4\u529b\u65bc\u6210\u70ba\u7cb5\u6e2f\u6fb3\u5927\u7063\u5340\u512a\u79c0\u7684\u751f\u7269\u91ab\u85e5\u7522\u696d\u570b\u6709\u5275\u6295\u516c\u53f8\u548c\u570b\u5167\u77e5\u540d\u7684\u5e02\u5834\u5316\u6bcd\u57fa\u91d1\u7ba1\u7406\u6a5f\u69cb\u3002<\/p>\n

\u95dc\u65bc\u77f3\u85e5\u7d0d\u5fb7<\/p>\n

\u77f3\u85e5\u7d0d\u5fb7\u662f\u77f3\u85e5\u96c6\u5718\u548c\u7d0d\u5fb7\u8cc7\u672c\u5408\u4f5c\u7d44\u5efa\u7684\u91ab\u85e5\u6295\u8cc7\u57fa\u91d1\uff0c\u7531\u77f3\u85e5\u96c6\u5718\u4e0b\u5c6c\u7684\u4e0a\u6d77\u77f3\u8c50\u6615\u532f\u5275\u696d\u6295\u8cc7\u7ba1\u7406\u6709\u9650\u516c\u53f8\u7ba1\u7406\u3002<\/p>\n

\u77f3\u85e5\u96c6\u5718\u662f\u4e00\u5bb6\u96c6\u5275\u65b0\u85e5\u7269\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u70ba\u4e00\u9ad4\u7684\u570b\u5bb6\u7d1a\u5275\u65b0\u578b\u4f01\u696d\u3002\u5728\u6e2f\u4e0a\u5e02\u516c\u53f8\uff0801093.HK\uff09\u8e8b\u8eab\u5343\u5104\u5e02\u503c\u4ff1\u6a02\u90e8\u3002\u77f3\u85e5\u96c6\u5718\u7522\u54c1\u92b7\u552e\u904d\u53ca\u5168\u7403100\u591a\u500b\u570b\u5bb6\u548c\u5730\u5340\uff0c\u670936\u500b\u54c1\u7a2e\u55ae\u54c1\u7a2e\u92b7\u552e\u904e\u5104\u5143\u3002<\/p>\n

\n<\/div>","protected":false},"excerpt":{"rendered":"

\u65b0\u52a0\u5761\u548c\u4e2d\u570b\u5ee3\u5dde2023\u5e746\u670827\u65e5 \/\u7f8e\u901a\u793e\/ — 2023\u5e746\u670827\u65e5\uff0c\u4f86\u6069\u751f\u7269\uff08Lion TCR\uff09\u5ba3\u4f48\u5b8c\u6210\u8d853\u5104\u5143B2\u8f2a\u878d\u8cc7\uff0c\u7531\u5ee3\u5dde\u7522\u6295\u9818\u6295\u3001\u5ee3\u5dde\u9ad8\u65b0\u5340\u96c6\u5718\u76f4\u5c6c\u4f01\u696d\u570b\u805a\u5275\u6295\u8207\u77f3\u85e5\u7d0d\u5fb7\u57fa\u91d1\u5171\u540c\u5b8c\u6210\u3002\u878d\u8cc7\u8cc7\u91d1\u5c07\u4e3b\u8981\u7528\u65bc\u652f\u6301\u4f86\u6069\u751f\u7269\u81e8\u5e8a\u8a66\u9a57\u7684\u63a8\u9032\u3001\u5ee3\u5ddeGMP\u7d30\u80de\u8eca\u9593\u7684\u5efa\u8a2d\u4ee5\u53ca\u7814\u767c\u7ba1\u7dda\u7684\u62d3\u5c55\u7b49\u3002 2023\u5e746\u670826\u65e5\uff0c\u5728\u65b0\u52a0\u5761\u885b\u751f\u90e8\u90e8\u9577\u738b\u4e59\u5eb7\u5148\u751f\u548c\u5ee3\u6771\u7701\u7701\u9577\u738b\u5049\u4e2d\u5148\u751f\u7684\u5171\u540c\u898b\u8b49\u4e0b\uff0c\u4f86\u6069\u751f\u7269\u8207\u5ee3\u5dde\u7522\u6295\u3001\u570b\u805a\u5275\u6295\u3001\u77f3\u85e5\u7d0d\u5fb7\u57fa\u91d1\u5728\u65b0\u52a0\u5761-\u5ee3\u6771\u5408\u4f5c\u7406\u4e8b\u6703\u7b2c\u5341\u4e09\u6b21\u6703\u8b70\u4e0a\u9032\u884c\u4e86\u6b64\u6b21\u878d\u8cc7\u6295\u8cc7\u5354\u8b70\u7684\u7c3d\u7d04\u3002 \u4f86\u6069\u751f\u7269\u5728\u5ee3\u6771-\u65b0\u52a0\u5761\u5408\u4f5c\u7406\u4e8b\u6703\u7b2c\u5341\u4e09\u6b21\u6703\u8b70\u4e0a\u7c3d\u7d04 \u4f86\u6069\u751f\u7269\u76ee\u524d\u5df2\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u8207\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6388\u4e88\u7684\u570b\u969b\u591a\u4e2d\u5fc3Ib\/II\u671f\u7684IND\u81e8\u5e8a\u6279\u4ef6\uff0c\u9019\u662f\u5168\u7403\u7b2c\u4e00\u500b\u7d93FDA\u6279\u51c6\uff0c\u5229\u7528TCR-T\u7d30\u80de\u6cbb\u7642\u4e59\u809d\u76f8\u95dc\u809d\u7d30\u80de\u764c\u7684\u570b\u969b\u591a\u4e2d\u5fc3\u81e8\u5e8a\u8a66\u9a57\uff0c\u76ee\u524d\u5df2\u5b8c\u6210\u591a\u4f8b\u60a3\u8005\u56de\u8f38\uff0c\u6b64TCR-T\u7d30\u80de\u7642\u6cd5\u9084\u7372\u5f97\u4e86FDA\u6388\u4e88\u7684\u5feb\u901f\u901a\u9053\u8a8d\u5b9a\uff08Fast Track\uff09\u548c\u5b64\u5152\u85e5\uff08Orphan Drug\uff09\u8cc7\u683c\u3002 \u4f86\u6069\u751f\u7269\u65bc2015\u5e74\u5f9e\u65b0\u52a0\u5761\u79d1\u6280\u7814\u7a76\u5c40\uff08A*STAR\uff09\u5b75\u5316\u800c\u51fa\uff0c\u9996\u6b3e\u7522\u54c1\u70baFirst-in-Class HBV\u7279\u7570\u6027TCR-T\u7d30\u80de\u7642\u6cd5\uff0c\u4e26\u901a\u904emRNA\u6280\u8853\u7de8\u78bcTCR\uff0c\u7528\u65bc\u6cbb\u7642\u809d\u7d30\u80de\u764c\uff0c\u5df2\u7d93\u5c55\u73fe\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u986f\u8457\u7642\u6548\u3002\u76ee\u524d\uff0c\u4f86\u6069\u751f\u7269\u5df2\u7d93\u5efa\u7acb\u4e86TCR\u767c\u73fe\u5e73\u53f0\u8207mRNA\u6280\u8853\u5e73\u53f0\uff0c\u5728\u9019\u5169\u500b\u5e73\u53f0\u57fa\u790e\u4e0a\u62d3\u5c55\u7522\u54c1\u7ba1\u7dda\uff0c\u901a\u904e\u9776\u5411\u4e0d\u540c\u9776\u9ede\u6cbb\u7642\u591a\u7a2e\u5be6\u9ad4\u7624\u3002\u4f86\u6069\u751f\u7269\u4f48\u5c40\u4e86\u5f9e\u81ea\u9ad4\u7d30\u80de\u7642\u6cd5\u5230\u73fe\u8ca8\u578b\u7642\u6cd5\u7522\u54c1\uff0c\u4ee5\u63d0\u9ad8\u60a3\u8005\u7684\u53ef\u53ca\u6027\uff0c\u70ba\u5c1a\u672a\u89e3\u6c7a\u7684\u81e8\u5e8a\u9700\u6c42\u63d0\u4f9b\u5275\u65b0\u7642\u6cd5\u3002 \u5c0d\u65bc\u672c\u8f2a\u878d\u8cc7\uff0c\u4f86\u6069\u751f\u7269\u9996\u5e2d\u57f7\u884c\u5b98\u5f6d\u66c9\u660e\u535a\u58eb\u8868\u793a\uff1a\u300c\u6b64\u6b21\u878d\u8cc7\u6210\u529f\u5c07\u52a9\u529b\u4f86\u6069\u751f\u7269\u6309\u7167\u5df2\u5efa\u7acb\u7684\u6280\u8853\u5e73\u53f0\u767c\u5c55\u6230\u7565\u5feb\u901f\u7a69\u6b65\u63a8\u9032\u7522\u54c1\u7ba1\u7dda\u3002 \u540c\u6642\u4e5f\u6709\u52a9\u65bc\u4f86\u6069\u751f\u7269\u9032\u4e00\u6b65\u4f9d\u6258\u4e2d\u65b0\u5408\u4f5c\u7684\u570b\u969b\u5e73\u53f0\u5927\u529b\u767c\u5c55\u79d1\u6280\u5275\u65b0\uff0c\u651c\u624b\u5ee3\u5dde\u7522\u6295\u3001\u5ee3\u5dde\u9ad8\u65b0\u5340\u96c6\u5718\u53ca\u77f3\u85e5\u96c6\u5718\u5728\u65b0\u52a0\u5761\u548c\u5927\u7063\u5340\u69cb\u7bc9\u570b\u969b\u751f\u7269\u79d1\u6280\u751f\u614b\u5708\uff0c\u5efa\u8a2d\u7d30\u80de\u6cbb\u7642\u9818\u57df\u7684\u793a\u7bc4\u55ae\u4f4d\uff0c\u9020\u798f\u60a3\u8005\uff0c\u56de\u994b\u793e\u6703\u3002\u300d \u4f86\u6069\u751f\u7269\u65bc2022\u5e746\u6708\u548c\u5ee3\u5dde\u5e02\u9ec3\u57d4\u5340\u653f\u5e9c\u5728\u751f\u7269\u7522\u696d\u5927\u6703\u4e0a\u6b63\u5f0f\u7c3d\u7d04\uff0c\u5c07\u4e2d\u570b\u7e3d\u90e8\u843d\u5730\u5ee3\u5dde\u4e2d\u65b0\u77e5\u8b58\u57ce\uff0c\u62d3\u5c55\u570b\u969b\u767c\u5c55\u7a7a\u9593\u3002\u5f6d\u66c9\u660e\u535a\u58eb\u9032\u4e00\u6b65\u4ecb\u7d39\uff0c\u300c\u5ee3\u5dde\u64c1\u6709\u4e2d\u570b\u9802\u5c16\u7684\u7684\u91ab\u9662\u8cc7\u6e90\uff0c\u653f\u5e9c\u4e5f\u7d66\u4e88\u91ab\u85e5\u4f01\u696d\u5f88\u591a\u653f\u7b56\u548c\u8cc7\u91d1\u652f\u6301\uff0c\u6211\u5011\u770b\u5230\u4e86\u5ee3\u5dde\u751f\u7269\u91ab\u85e5\u7522\u696d\u767c\u5c55\u7684\u6c7a\u5fc3\u548c\u53cb\u597d\u7684\u751f\u614b\u74b0\u5883\uff0c\u6240\u4ee5\u6c7a\u5b9a\u5c07\u4e2d\u570b\u7e3d\u90e8\u653e\u5728\u5ee3\u5dde\uff0c\u9019\u5c07\u662f\u96c6\u7ba1\u7dda\u7814\u767c\u3001GMP\u751f\u7522\u548c\u81e8\u5e8a\u8a3b\u518a\u65bc\u4e00\u9ad4\u7684\u7d9c\u5408\u57fa\u5730\u3002\u4e2d\u570b\u7e3d\u90e8\u7d9c\u5408\u57fa\u5730\u4f54\u5730\u7e3d\u9762\u7a4d\u8d85\u904e5000\u5e73\u7c73\uff0c\u843d\u6210\u5f8c\u5c07\u5f62\u6210\u9589\u74b0\u7684\u7b26\u5408GMP\u6a19\u6e96\u7684\u7d30\u80de\u7522\u54c1\u751f\u7522\u3001\u653e\u884c\u3001\u51b7\u93c8\u904b\u8f38\u3001\u60a3\u8005\u56de\u8f38\u7b49\u7aef\u5230\u7aef\u904b\u71df\u80fd\u529b\uff0c\u670d\u52d9\u4e2d\u570b\u60a3\u8005\u3002\u300d \u4f86\u6069\u751f\u7269\u4e2d\u570b\u7e3d\u90e8\u5ee3\u5dde\u570b\u969b\u751f\u7269\u91ab\u85e5\u5275\u65b0\u4e2d\u5fc3 \u00a0 \u4f86\u6069\u751f\u7269\u4e2d\u570b\u7e3d\u90e8\u5ee3\u5dde\u4e2d\u65b0\u667a\u6167\u5712 \u5c0d\u65bc\u672c\u6b21\u6295\u8cc7\uff0c\u9664\u4e86\u8003\u616e\u5230\u4f86\u6069\u751f\u7269\u81ea\u8eab\u5728\u6280\u8853\u65b9\u9762\u7684\u904e\u786c\u5be6\u529b\u5916\uff0c\u6295\u8cc7\u65b9\u4e5f\u5404\u6709\u8003\u91cf\u3002 \u5ee3\u5dde\u7522\u6295\u7684\u6295\u8cc7\u901a\u5e38\u6709\u4e09\u500b\u5927\u65b9\u5411\uff0c\u4e00\u662f\u6295\u8cc7\u5ee3\u5dde\uff0c\u4ee5\u6295\u4fc3\u5f15\u63a8\u52d5\u91cd\u5927\u9805\u76ee\u843d\u5730\u3002\u4e8c\u662f\u6295\u8cc7\u5be6\u9ad4\uff0c\u4ee5\u6295\u4fc3\u7522\u63a8\u9032\u7522\u696d\u8f49\u578b\u5347\u7d1a\u3002\u4e09\u662f\u6295\u8cc7\u672a\u4f86\uff0c\u4ee5\u6295\u4fc3\u5275\u6436\u4f54\u672a\u4f86\u524d\u6cbf\u9663\u5730\u3002\u5ee3\u5dde\u7522\u6295\u96c6\u5718\u7e3d\u6703\u8a08\u5e2b\u90dd\u5fc5\u50b3\u6307\u51fa\uff1a \u5ee3\u5dde\u7522\u6295\u96c6\u5718\u5728\u751f\u7269\u91ab\u85e5\u8207\u5065\u5eb7\u7522\u696d\u9818\u57df\u5df2\u7d2f\u8a08\u6295\u8cc7\u8d8514\u5104\u5143\uff0c\u767c\u63ee\u7522\u696d\u8cc7\u672c\u5f15\u9818\u4f5c\u7528\uff0c\u767c\u6398\u884c\u696d\u9f8d\u982d\u4f01\u696d\u7cbe\u6e96\u300c\u704c\u6e89\u300d\uff0c\u70ba\u5ee3\u5dde\u751f\u7269\u91ab\u85e5\u8207\u5065\u5eb7\u7522\u696d\u88dc\u93c8\u5f37\u93c8\u3002\u6b64\u6b21\u5c0d\u4f86\u6069\u751f\u7269\u7684\u6295\u8cc7\uff0c\u662f\u5ee3\u5dde\u5e02\u5728\u5275\u65b0\u5347\u7d1a\u6a5f\u9047\u4e2d\u7684\u6838\u5fc3\u9700\u6c42\uff0c\u5ee3\u5dde\u7522\u6295\u96c6\u5718\u901a\u904e\u6a39\u7acb\u300c\u6295\u8cc7\u5728\u4eca\u5929\u3001\u529f\u6548\u5728\u672a\u4f86\u300d\u7684\u767c\u5c55\u7406\u5ff5\uff0c\u4ee5\u300c\u8010\u5fc3\u8cc7\u672c\u300d\u5168\u9031\u671f\u966a\u4f34\u7684\u9577\u671f\u601d\u7dad\u70ba\u7522\u696d\u6295\u8cc7\u9805\u76ee\u63d0\u4f9b\u8cc7\u91d1\u3001\u8cc7\u6e90\u3001\u670d\u52d9\u7b49\u7684\u300c\u4e00\u652c\u5b50\u300d\u89e3\u6c7a\u65b9\u6848\uff0c\u63a8\u52d5\u5ee3\u5dde\u7522\u696d\u9ad8\u8cea\u91cf\u767c\u5c55\u3002 \u570b\u805a\u5275\u6295\u66f4\u591a\u7684\u662f\u5e0c\u671b\u548c\u4f86\u6069\u751f\u7269\u7684\u5408\u4f5c\u80fd\u5920\u5e36\u52d5\u52a0\u901f\u5ee3\u5dde\u5e02\u9ec3\u57d4\u5340\u7684\u751f\u7269\u91ab\u85e5\u767c\u5c55\u3002\u570b\u805a\u5275\u6295\u7684\u8463\u4e8b\u9577\u694a\u66e6\u8868\u793a\uff1a \u4f86\u6069\u751f\u7269\u64c1\u6709\u539f\u5275\u7684\u9776\u9ede\u6280\u8853\u53ca\u5b8c\u5584\u7684\u77e5\u8b58\u7522\u6b0a\uff0c\u5275\u65b0\u7684mRNA\u7de8\u78bc\u7684TCR-T\u5e73\u53f0\u6280\u8853\u53ef\u6301\u7e8c\u62d3\u5c55\u81f3\u591a\u7a2e\u5be6\u9ad4\u7624\uff0c\u4f86\u6069\u751f\u7269\u7684\u52a0\u5165\u5c07\u52a9\u529b\u9ec3\u57d4\u5340\u63a8\u9032\u751f\u7269\u91ab\u85e5\u7522\u696d\u767c\u5c55\uff0c\u5e36\u52d5\u9ad8\u65b0\u751f\u7269\u7522\u696d\u96c6\u7fa4\u7684\u6210\u9577\uff0c\u63d0\u5347\u5ee3\u5dde\u5e02\u4e43\u81f3\u5927\u7063\u5340\u751f\u7269\u91ab\u85e5\u5275\u65b0\u80fd\u7d1a\u3002 \u77f3\u85e5\u7d0d\u5fb7\u57fa\u91d1\u5247\u662f\u770b\u6e96\u4e86\u4f86\u6069\u751f\u7269\u5728\u884c\u696d\u5167\u9818\u5148\u7684\u6280\u8853\u5be6\u529b\u548c\u767c\u5c55\u524d\u666f\uff0c\u4ee5\u53ca\u5408\u4f5c\u53ef\u80fd\u7d66\u96d9\u65b9\u5e36\u4f86\u7684\u5de8\u5927\u597d\u8655\u3002\u77f3\u85e5\u7d0d\u5fb7\u57fa\u91d1\u7ba1\u7406\u5408\u5925\u4eba\u5b6b\u805a\u6c11\u8868\u793a\uff1a\u300c\u4f86\u6069\u751f\u7269\u7684\u539f\u5275\u79d1\u7814\u5be6\u529b\uff0c\u570b\u969b\u5316\u7684\u5718\u968a\u80cc\u666f\uff0c\u5c08\u6ce8\u5728\u539f\u5275\u79d1\u6280\u7684\u63a2\u7d22\u4ee5\u53ca\u5728mRNA\u548cTCR-T\u8cfd\u9053\u4e0a\u7684\u6df1\u8015\u5438\u5f15\u4e86\u6211\u5011\u7684\u6ce8\u610f\u3002\u77f3\u85e5\u96c6\u5718\u662f\u4e2d\u570b\u552f\u4e00\u4e00\u5bb6\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u6279\u51c6\u7dca\u6025\u4f7f\u7528\u7684mRNA\u65b0\u51a0\u75ab\u82d7\u4f01\u696d\uff0c\u5728\u884c\u696d\u4e2d\u8eab\u7d93\u767e\u6230\uff0c\u5728\u81e8\u5e8a\u7814\u7a76\u3001\u5e02\u5834\u63a8\u5ee3\u7b49\u5404\u500b\u74b0\u7bc0\u64c1\u6709\u8c50\u5bcc\u7684\u8cc7\u6e90\u3002\u6b64\u6b21\u6295\u8cc7\u4f86\u6069\u751f\u7269\uff0c\u5e0c\u671b\u9032\u4e00\u6b65\u63a8\u9032\u4f86\u6069\u751f\u7269\u548c\u77f3\u85e5\u96c6\u5718\u5728\u4ee5mRNA\u70ba\u57fa\u790e\u7684\u591a\u7a2e\u6210\u85e5\u65b9\u5f0f\u4e0a\u5171\u540c\u63a2\u7d22\u5408\u4f5c\uff0c\u82e5\u5728\u6210\u85e5\u6027\u4e0a\u5f97\u5230\u62d3\u5c55\u53ca\u7a81\u7834\uff0c\u5c07\u4f86\u6709\u671b\u5728\u81e8\u5e8a\u548c\u5546\u696d\u5316\u7b49\u65b9\u9762\u501f\u52a9\u96d9\u65b9\u8cc7\u6e90\u5f62\u6210\u96d9\u8d0f\u7684\u5c40\u9762\u3002\u300d \u95dc\u65bc\u5ee3\u5dde\u7522\u6295 \u5ee3\u5dde\u7522\u696d\u6295\u8cc7\u63a7\u80a1\u96c6\u5718\u6709\u9650\u516c\u53f8\uff08\u7c21\u7a31\u300c\u5ee3\u5dde\u7522\u6295\u96c6\u5718\u300d\uff09 \u5ee3\u5dde\u7522\u6295\u96c6\u5718\u5805\u6301\u300c\u6295\u8cc7\u5ee3\u5dde\u3001\u6295\u8cc7\u5be6\u9ad4\u3001\u6295\u8cc7\u672a\u4f86\u300d\u7406\u5ff5\uff0c\u6a39\u7acb\u300c\u8010\u5fc3\u8cc7\u672c\u300d\u7684\u7522\u696d\u767c\u5c55\u601d\u7dad\uff0c\u7acb\u8db3\u6230\u7565\u6295\u8cc7\u767c\u5c55\u5e73\u53f0\u3001\u570b\u6709\u80a1\u6b0a\u6301\u80a1\u5e73\u53f0\u3001\u8cc7\u672c\u904b\u4f5c\u7ba1\u7406\u5e73\u53f0\u4e09\u5927\u529f\u80fd\u5b9a\u4f4d\uff0c\u7a4d\u6975\u64d4\u7576\u7522\u696d\u6295\u884c\u548c\u8cc7\u672c\u904b\u71df\u5169\u5927\u89d2\u8272\uff0c\u63a7\u53c3\u80a1\u5ee3\u6c7d\u96c6\u5718\u3001\u5ee3\u85e5\u96c6\u5718\u3001\u5ee3\u5dde\u767c\u5c55\u3001\u73e0\u6c5f\u5564\u9152\u3001\u5ee3\u5dde\u9152\u5bb6\u3001\u73e0\u6c5f\u92fc\u7434\u3001\u5dba\u5357\u63a7\u80a1\u3001\u4e2d\u570b\u96fb\u5efa\u3001\u5b5a\u80fd\u79d1\u6280\u3001\u5730\u9435\u8a2d\u8a08\u9662\u7b4910\u591a\u5bb6\u4e0a\u5e02\u516c\u53f8\u4ee5\u53ca\u8d8a\u79c0\u96c6\u5718\u3001\u570b\u65b0\u8b49\u5238\u3001\u7d2b\u5149\u96c6\u5718\u3001\u7cb5\u82af\u534a\u5c0e\u9ad4\u3001\u4e2d\u79d1\u5b87\u822a\u7b49\u4e00\u6279\u9f8d\u982d\u4f01\u696d\uff0c\u727d\u982d\u7d44\u5efa\u4e26\u904b\u4f5c\u5be6\u65bd1500\u5104\u5143\u5ee3\u5dde\u7522\u696d\u6295\u8cc7\u6bcd\u57fa\u91d1\u548c500\u5104\u5143\u5ee3\u5dde\u5275\u65b0\u6295\u8cc7\u6bcd\u57fa\u91d1\u3002\u96c6\u5718\u64c1\u67094\u5bb6\u57fa\u91d1\u7ba1\u7406\u516c\u53f8\uff0c\u6295\u8cc7\u8a2d\u7acb\u4e26\u8207\u982d\u90e8\u6a5f\u69cb\u5408\u4f5c\u8a2d\u7acb\u57fa\u91d150\u591a\u652f\uff0c\u63d0\u4f9b\u5168\u93c8\u689d\u57fa\u91d1\u6295\u8cc7\u670d\u52d9\uff0c\u5df2\u5f62\u6210\u300c\u57fa\u91d1\u7ba1\u7406+\u7522\u696d\u6295\u8cc7+\u8cc7\u672c\u904b\u71df+\u5712\u5340\u670d\u52d9+\u79d1\u6280\u670d\u52d9\u300d\u7684\u696d\u52d9\u9ad4\u7cfb\u548c\u300c\u4e0a\u5e02\u516c\u53f8\u96c6\u7fa4+\u529f\u80fd\u5e73\u53f0\u96c6\u7fa4+\u7522\u696d\u767c\u5c55\u57fa\u91d1\u7fa4+\u5275\u65b0\u50f9\u503c\u5712\u5340\u300d\u7684\u904b\u4f5c\u67b6\u69cb\uff0c\u9023\u7e8c\u4e94\u5e74\u8e8b\u8eab\u300c\u4e2d\u570b\u4f01\u696d500\u5f37\u300d\u548c\u300c\u4e2d\u570b\u670d\u52d9\u696d\u4f01\u696d500\u5f37\u300d\uff0c\u5168\u529b\u6253\u9020\u5e02\u5834\u5316\u3001\u5c08\u696d\u5316\u3001\u570b\u969b\u5316\u7684\u4e00\u6d41\u570b\u6709\u8cc7\u672c\u6295\u8cc7\u904b\u71df\u5e73\u53f0\u3002 \u95dc\u65bc\u570b\u805a\u5275\u6295 \u570b\u805a\u5275\u6295\u662f\u5ee3\u5dde\u9ad8\u65b0\u5340\u96c6\u5718\u5168\u8cc7\u79c1\u52df\u80a1\u6b0a\u57fa\u91d1\u5b50\u516c\u53f8\uff0c\u7ba1\u7406\u53ca\u53c3\u8207\u7684\u57fa\u91d1\u898f\u6a21\u903e30\u5104\u5143\u3002\u901a\u904e\u300c\u751f\u7269\u91ab\u85e5\u7522\u696d\u57fa\u91d1\u300d\u767c\u63ee\u7684\u8cc7\u91d1\u5f15\u9818\u653e\u5927\u6548\u7528\uff0c\u53c3\u8207\u8a2d\u7acb\u4e86\u300c\u4e2d\u4ee5\u4e8c\u671f\u57fa\u91d1\u300d\u3001\u300c\u5ee3\u6771\u4e2d\u91ab\u85e5\u5927\u5065\u5eb7\u57fa\u91d1\u300d\uff0c\u9678\u7e8c\u8207\u7d93\u7def\u4e2d\u570b\u3001\u677e\u79be\u8cc7\u672c\u3001\u5143\u79be\u539f\u9ede\u7b49\u77e5\u540d\u6295\u8cc7\u6a5f\u69cb\u9054\u6210\u5408\u4f5c\uff0c\u81f4\u529b\u65bc\u6210\u70ba\u7cb5\u6e2f\u6fb3\u5927\u7063\u5340\u512a\u79c0\u7684\u751f\u7269\u91ab\u85e5\u7522\u696d\u570b\u6709\u5275\u6295\u516c\u53f8\u548c\u570b\u5167\u77e5\u540d\u7684\u5e02\u5834\u5316\u6bcd\u57fa\u91d1\u7ba1\u7406\u6a5f\u69cb\u3002 \u95dc\u65bc\u77f3\u85e5\u7d0d\u5fb7 \u77f3\u85e5\u7d0d\u5fb7\u662f\u77f3\u85e5\u96c6\u5718\u548c\u7d0d\u5fb7\u8cc7\u672c\u5408\u4f5c\u7d44\u5efa\u7684\u91ab\u85e5\u6295\u8cc7\u57fa\u91d1\uff0c\u7531\u77f3\u85e5\u96c6\u5718\u4e0b\u5c6c\u7684\u4e0a\u6d77\u77f3\u8c50\u6615\u532f\u5275\u696d\u6295\u8cc7\u7ba1\u7406\u6709\u9650\u516c\u53f8\u7ba1\u7406\u3002 \u77f3\u85e5\u96c6\u5718\u662f\u4e00\u5bb6\u96c6\u5275\u65b0\u85e5\u7269\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u70ba\u4e00\u9ad4\u7684\u570b\u5bb6\u7d1a\u5275\u65b0\u578b\u4f01\u696d\u3002\u5728\u6e2f\u4e0a\u5e02\u516c\u53f8\uff0801093.HK\uff09\u8e8b\u8eab\u5343\u5104\u5e02\u503c\u4ff1\u6a02\u90e8\u3002\u77f3\u85e5\u96c6\u5718\u7522\u54c1\u92b7\u552e\u904d\u53ca\u5168\u7403100\u591a\u500b\u570b\u5bb6\u548c\u5730\u5340\uff0c\u670936\u500b\u54c1\u7a2e\u55ae\u54c1\u7a2e\u92b7\u552e\u904e\u5104\u5143\u3002<\/p>\n","protected":false},"author":0,"featured_media":13213,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_generate-full-width-content":"","spay_email":"","footnotes":""},"categories":[1],"tags":[],"yoast_head":"\n\u4f86\u6069\u751f\u7269\u5ba3\u4f48\u5b8c\u6210\u8d853\u5104\u5143B2\u8f2a\u878d\u8cc7\uff0c\u5168\u7403\u9818\u8dd1mRNA\u7de8\u78bc\u7684TCR-T\u7d30\u80de\u6cbb\u7642\u5be6\u9ad4\u7624 - \u9999\u6e2f\u7279\u8a31\u7d93\u71df<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.franchise.com.hk\/en\/%e4%be%86%e6%81%a9%e7%94%9f%e7%89%a9%e5%ae%a3%e4%bd%88%e5%ae%8c%e6%88%90%e8%b6%853%e5%84%84%e5%85%83b2%e8%bc%aa%e8%9e%8d%e8%b3%87%ef%bc%8c%e5%85%a8%e7%90%83%e9%a0%98%e8%b7%91mrna%e7%b7%a8%e7%a2%bc\/13212\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u4f86\u6069\u751f\u7269\u5ba3\u4f48\u5b8c\u6210\u8d853\u5104\u5143B2\u8f2a\u878d\u8cc7\uff0c\u5168\u7403\u9818\u8dd1mRNA\u7de8\u78bc\u7684TCR-T\u7d30\u80de\u6cbb\u7642\u5be6\u9ad4\u7624 - \u9999\u6e2f\u7279\u8a31\u7d93\u71df\" \/>\n<meta property=\"og:description\" content=\"\u65b0\u52a0\u5761\u548c\u4e2d\u570b\u5ee3\u5dde2023\u5e746\u670827\u65e5 \/\u7f8e\u901a\u793e\/ — 2023\u5e746\u670827\u65e5\uff0c\u4f86\u6069\u751f\u7269\uff08Lion TCR\uff09\u5ba3\u4f48\u5b8c\u6210\u8d853\u5104\u5143B2\u8f2a\u878d\u8cc7\uff0c\u7531\u5ee3\u5dde\u7522\u6295\u9818\u6295\u3001\u5ee3\u5dde\u9ad8\u65b0\u5340\u96c6\u5718\u76f4\u5c6c\u4f01\u696d\u570b\u805a\u5275\u6295\u8207\u77f3\u85e5\u7d0d\u5fb7\u57fa\u91d1\u5171\u540c\u5b8c\u6210\u3002\u878d\u8cc7\u8cc7\u91d1\u5c07\u4e3b\u8981\u7528\u65bc\u652f\u6301\u4f86\u6069\u751f\u7269\u81e8\u5e8a\u8a66\u9a57\u7684\u63a8\u9032\u3001\u5ee3\u5ddeGMP\u7d30\u80de\u8eca\u9593\u7684\u5efa\u8a2d\u4ee5\u53ca\u7814\u767c\u7ba1\u7dda\u7684\u62d3\u5c55\u7b49\u3002 2023\u5e746\u670826\u65e5\uff0c\u5728\u65b0\u52a0\u5761\u885b\u751f\u90e8\u90e8\u9577\u738b\u4e59\u5eb7\u5148\u751f\u548c\u5ee3\u6771\u7701\u7701\u9577\u738b\u5049\u4e2d\u5148\u751f\u7684\u5171\u540c\u898b\u8b49\u4e0b\uff0c\u4f86\u6069\u751f\u7269\u8207\u5ee3\u5dde\u7522\u6295\u3001\u570b\u805a\u5275\u6295\u3001\u77f3\u85e5\u7d0d\u5fb7\u57fa\u91d1\u5728\u65b0\u52a0\u5761-\u5ee3\u6771\u5408\u4f5c\u7406\u4e8b\u6703\u7b2c\u5341\u4e09\u6b21\u6703\u8b70\u4e0a\u9032\u884c\u4e86\u6b64\u6b21\u878d\u8cc7\u6295\u8cc7\u5354\u8b70\u7684\u7c3d\u7d04\u3002 \u4f86\u6069\u751f\u7269\u5728\u5ee3\u6771-\u65b0\u52a0\u5761\u5408\u4f5c\u7406\u4e8b\u6703\u7b2c\u5341\u4e09\u6b21\u6703\u8b70\u4e0a\u7c3d\u7d04 \u4f86\u6069\u751f\u7269\u76ee\u524d\u5df2\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u8207\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6388\u4e88\u7684\u570b\u969b\u591a\u4e2d\u5fc3Ib\/II\u671f\u7684IND\u81e8\u5e8a\u6279\u4ef6\uff0c\u9019\u662f\u5168\u7403\u7b2c\u4e00\u500b\u7d93FDA\u6279\u51c6\uff0c\u5229\u7528TCR-T\u7d30\u80de\u6cbb\u7642\u4e59\u809d\u76f8\u95dc\u809d\u7d30\u80de\u764c\u7684\u570b\u969b\u591a\u4e2d\u5fc3\u81e8\u5e8a\u8a66\u9a57\uff0c\u76ee\u524d\u5df2\u5b8c\u6210\u591a\u4f8b\u60a3\u8005\u56de\u8f38\uff0c\u6b64TCR-T\u7d30\u80de\u7642\u6cd5\u9084\u7372\u5f97\u4e86FDA\u6388\u4e88\u7684\u5feb\u901f\u901a\u9053\u8a8d\u5b9a\uff08Fast Track\uff09\u548c\u5b64\u5152\u85e5\uff08Orphan Drug\uff09\u8cc7\u683c\u3002 \u4f86\u6069\u751f\u7269\u65bc2015\u5e74\u5f9e\u65b0\u52a0\u5761\u79d1\u6280\u7814\u7a76\u5c40\uff08A*STAR\uff09\u5b75\u5316\u800c\u51fa\uff0c\u9996\u6b3e\u7522\u54c1\u70baFirst-in-Class HBV\u7279\u7570\u6027TCR-T\u7d30\u80de\u7642\u6cd5\uff0c\u4e26\u901a\u904emRNA\u6280\u8853\u7de8\u78bcTCR\uff0c\u7528\u65bc\u6cbb\u7642\u809d\u7d30\u80de\u764c\uff0c\u5df2\u7d93\u5c55\u73fe\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u986f\u8457\u7642\u6548\u3002\u76ee\u524d\uff0c\u4f86\u6069\u751f\u7269\u5df2\u7d93\u5efa\u7acb\u4e86TCR\u767c\u73fe\u5e73\u53f0\u8207mRNA\u6280\u8853\u5e73\u53f0\uff0c\u5728\u9019\u5169\u500b\u5e73\u53f0\u57fa\u790e\u4e0a\u62d3\u5c55\u7522\u54c1\u7ba1\u7dda\uff0c\u901a\u904e\u9776\u5411\u4e0d\u540c\u9776\u9ede\u6cbb\u7642\u591a\u7a2e\u5be6\u9ad4\u7624\u3002\u4f86\u6069\u751f\u7269\u4f48\u5c40\u4e86\u5f9e\u81ea\u9ad4\u7d30\u80de\u7642\u6cd5\u5230\u73fe\u8ca8\u578b\u7642\u6cd5\u7522\u54c1\uff0c\u4ee5\u63d0\u9ad8\u60a3\u8005\u7684\u53ef\u53ca\u6027\uff0c\u70ba\u5c1a\u672a\u89e3\u6c7a\u7684\u81e8\u5e8a\u9700\u6c42\u63d0\u4f9b\u5275\u65b0\u7642\u6cd5\u3002 \u5c0d\u65bc\u672c\u8f2a\u878d\u8cc7\uff0c\u4f86\u6069\u751f\u7269\u9996\u5e2d\u57f7\u884c\u5b98\u5f6d\u66c9\u660e\u535a\u58eb\u8868\u793a\uff1a\u300c\u6b64\u6b21\u878d\u8cc7\u6210\u529f\u5c07\u52a9\u529b\u4f86\u6069\u751f\u7269\u6309\u7167\u5df2\u5efa\u7acb\u7684\u6280\u8853\u5e73\u53f0\u767c\u5c55\u6230\u7565\u5feb\u901f\u7a69\u6b65\u63a8\u9032\u7522\u54c1\u7ba1\u7dda\u3002 \u540c\u6642\u4e5f\u6709\u52a9\u65bc\u4f86\u6069\u751f\u7269\u9032\u4e00\u6b65\u4f9d\u6258\u4e2d\u65b0\u5408\u4f5c\u7684\u570b\u969b\u5e73\u53f0\u5927\u529b\u767c\u5c55\u79d1\u6280\u5275\u65b0\uff0c\u651c\u624b\u5ee3\u5dde\u7522\u6295\u3001\u5ee3\u5dde\u9ad8\u65b0\u5340\u96c6\u5718\u53ca\u77f3\u85e5\u96c6\u5718\u5728\u65b0\u52a0\u5761\u548c\u5927\u7063\u5340\u69cb\u7bc9\u570b\u969b\u751f\u7269\u79d1\u6280\u751f\u614b\u5708\uff0c\u5efa\u8a2d\u7d30\u80de\u6cbb\u7642\u9818\u57df\u7684\u793a\u7bc4\u55ae\u4f4d\uff0c\u9020\u798f\u60a3\u8005\uff0c\u56de\u994b\u793e\u6703\u3002\u300d \u4f86\u6069\u751f\u7269\u65bc2022\u5e746\u6708\u548c\u5ee3\u5dde\u5e02\u9ec3\u57d4\u5340\u653f\u5e9c\u5728\u751f\u7269\u7522\u696d\u5927\u6703\u4e0a\u6b63\u5f0f\u7c3d\u7d04\uff0c\u5c07\u4e2d\u570b\u7e3d\u90e8\u843d\u5730\u5ee3\u5dde\u4e2d\u65b0\u77e5\u8b58\u57ce\uff0c\u62d3\u5c55\u570b\u969b\u767c\u5c55\u7a7a\u9593\u3002\u5f6d\u66c9\u660e\u535a\u58eb\u9032\u4e00\u6b65\u4ecb\u7d39\uff0c\u300c\u5ee3\u5dde\u64c1\u6709\u4e2d\u570b\u9802\u5c16\u7684\u7684\u91ab\u9662\u8cc7\u6e90\uff0c\u653f\u5e9c\u4e5f\u7d66\u4e88\u91ab\u85e5\u4f01\u696d\u5f88\u591a\u653f\u7b56\u548c\u8cc7\u91d1\u652f\u6301\uff0c\u6211\u5011\u770b\u5230\u4e86\u5ee3\u5dde\u751f\u7269\u91ab\u85e5\u7522\u696d\u767c\u5c55\u7684\u6c7a\u5fc3\u548c\u53cb\u597d\u7684\u751f\u614b\u74b0\u5883\uff0c\u6240\u4ee5\u6c7a\u5b9a\u5c07\u4e2d\u570b\u7e3d\u90e8\u653e\u5728\u5ee3\u5dde\uff0c\u9019\u5c07\u662f\u96c6\u7ba1\u7dda\u7814\u767c\u3001GMP\u751f\u7522\u548c\u81e8\u5e8a\u8a3b\u518a\u65bc\u4e00\u9ad4\u7684\u7d9c\u5408\u57fa\u5730\u3002\u4e2d\u570b\u7e3d\u90e8\u7d9c\u5408\u57fa\u5730\u4f54\u5730\u7e3d\u9762\u7a4d\u8d85\u904e5000\u5e73\u7c73\uff0c\u843d\u6210\u5f8c\u5c07\u5f62\u6210\u9589\u74b0\u7684\u7b26\u5408GMP\u6a19\u6e96\u7684\u7d30\u80de\u7522\u54c1\u751f\u7522\u3001\u653e\u884c\u3001\u51b7\u93c8\u904b\u8f38\u3001\u60a3\u8005\u56de\u8f38\u7b49\u7aef\u5230\u7aef\u904b\u71df\u80fd\u529b\uff0c\u670d\u52d9\u4e2d\u570b\u60a3\u8005\u3002\u300d \u4f86\u6069\u751f\u7269\u4e2d\u570b\u7e3d\u90e8\u5ee3\u5dde\u570b\u969b\u751f\u7269\u91ab\u85e5\u5275\u65b0\u4e2d\u5fc3 \u00a0 \u4f86\u6069\u751f\u7269\u4e2d\u570b\u7e3d\u90e8\u5ee3\u5dde\u4e2d\u65b0\u667a\u6167\u5712 \u5c0d\u65bc\u672c\u6b21\u6295\u8cc7\uff0c\u9664\u4e86\u8003\u616e\u5230\u4f86\u6069\u751f\u7269\u81ea\u8eab\u5728\u6280\u8853\u65b9\u9762\u7684\u904e\u786c\u5be6\u529b\u5916\uff0c\u6295\u8cc7\u65b9\u4e5f\u5404\u6709\u8003\u91cf\u3002 \u5ee3\u5dde\u7522\u6295\u7684\u6295\u8cc7\u901a\u5e38\u6709\u4e09\u500b\u5927\u65b9\u5411\uff0c\u4e00\u662f\u6295\u8cc7\u5ee3\u5dde\uff0c\u4ee5\u6295\u4fc3\u5f15\u63a8\u52d5\u91cd\u5927\u9805\u76ee\u843d\u5730\u3002\u4e8c\u662f\u6295\u8cc7\u5be6\u9ad4\uff0c\u4ee5\u6295\u4fc3\u7522\u63a8\u9032\u7522\u696d\u8f49\u578b\u5347\u7d1a\u3002\u4e09\u662f\u6295\u8cc7\u672a\u4f86\uff0c\u4ee5\u6295\u4fc3\u5275\u6436\u4f54\u672a\u4f86\u524d\u6cbf\u9663\u5730\u3002\u5ee3\u5dde\u7522\u6295\u96c6\u5718\u7e3d\u6703\u8a08\u5e2b\u90dd\u5fc5\u50b3\u6307\u51fa\uff1a \u5ee3\u5dde\u7522\u6295\u96c6\u5718\u5728\u751f\u7269\u91ab\u85e5\u8207\u5065\u5eb7\u7522\u696d\u9818\u57df\u5df2\u7d2f\u8a08\u6295\u8cc7\u8d8514\u5104\u5143\uff0c\u767c\u63ee\u7522\u696d\u8cc7\u672c\u5f15\u9818\u4f5c\u7528\uff0c\u767c\u6398\u884c\u696d\u9f8d\u982d\u4f01\u696d\u7cbe\u6e96\u300c\u704c\u6e89\u300d\uff0c\u70ba\u5ee3\u5dde\u751f\u7269\u91ab\u85e5\u8207\u5065\u5eb7\u7522\u696d\u88dc\u93c8\u5f37\u93c8\u3002\u6b64\u6b21\u5c0d\u4f86\u6069\u751f\u7269\u7684\u6295\u8cc7\uff0c\u662f\u5ee3\u5dde\u5e02\u5728\u5275\u65b0\u5347\u7d1a\u6a5f\u9047\u4e2d\u7684\u6838\u5fc3\u9700\u6c42\uff0c\u5ee3\u5dde\u7522\u6295\u96c6\u5718\u901a\u904e\u6a39\u7acb\u300c\u6295\u8cc7\u5728\u4eca\u5929\u3001\u529f\u6548\u5728\u672a\u4f86\u300d\u7684\u767c\u5c55\u7406\u5ff5\uff0c\u4ee5\u300c\u8010\u5fc3\u8cc7\u672c\u300d\u5168\u9031\u671f\u966a\u4f34\u7684\u9577\u671f\u601d\u7dad\u70ba\u7522\u696d\u6295\u8cc7\u9805\u76ee\u63d0\u4f9b\u8cc7\u91d1\u3001\u8cc7\u6e90\u3001\u670d\u52d9\u7b49\u7684\u300c\u4e00\u652c\u5b50\u300d\u89e3\u6c7a\u65b9\u6848\uff0c\u63a8\u52d5\u5ee3\u5dde\u7522\u696d\u9ad8\u8cea\u91cf\u767c\u5c55\u3002 \u570b\u805a\u5275\u6295\u66f4\u591a\u7684\u662f\u5e0c\u671b\u548c\u4f86\u6069\u751f\u7269\u7684\u5408\u4f5c\u80fd\u5920\u5e36\u52d5\u52a0\u901f\u5ee3\u5dde\u5e02\u9ec3\u57d4\u5340\u7684\u751f\u7269\u91ab\u85e5\u767c\u5c55\u3002\u570b\u805a\u5275\u6295\u7684\u8463\u4e8b\u9577\u694a\u66e6\u8868\u793a\uff1a \u4f86\u6069\u751f\u7269\u64c1\u6709\u539f\u5275\u7684\u9776\u9ede\u6280\u8853\u53ca\u5b8c\u5584\u7684\u77e5\u8b58\u7522\u6b0a\uff0c\u5275\u65b0\u7684mRNA\u7de8\u78bc\u7684TCR-T\u5e73\u53f0\u6280\u8853\u53ef\u6301\u7e8c\u62d3\u5c55\u81f3\u591a\u7a2e\u5be6\u9ad4\u7624\uff0c\u4f86\u6069\u751f\u7269\u7684\u52a0\u5165\u5c07\u52a9\u529b\u9ec3\u57d4\u5340\u63a8\u9032\u751f\u7269\u91ab\u85e5\u7522\u696d\u767c\u5c55\uff0c\u5e36\u52d5\u9ad8\u65b0\u751f\u7269\u7522\u696d\u96c6\u7fa4\u7684\u6210\u9577\uff0c\u63d0\u5347\u5ee3\u5dde\u5e02\u4e43\u81f3\u5927\u7063\u5340\u751f\u7269\u91ab\u85e5\u5275\u65b0\u80fd\u7d1a\u3002 \u77f3\u85e5\u7d0d\u5fb7\u57fa\u91d1\u5247\u662f\u770b\u6e96\u4e86\u4f86\u6069\u751f\u7269\u5728\u884c\u696d\u5167\u9818\u5148\u7684\u6280\u8853\u5be6\u529b\u548c\u767c\u5c55\u524d\u666f\uff0c\u4ee5\u53ca\u5408\u4f5c\u53ef\u80fd\u7d66\u96d9\u65b9\u5e36\u4f86\u7684\u5de8\u5927\u597d\u8655\u3002\u77f3\u85e5\u7d0d\u5fb7\u57fa\u91d1\u7ba1\u7406\u5408\u5925\u4eba\u5b6b\u805a\u6c11\u8868\u793a\uff1a\u300c\u4f86\u6069\u751f\u7269\u7684\u539f\u5275\u79d1\u7814\u5be6\u529b\uff0c\u570b\u969b\u5316\u7684\u5718\u968a\u80cc\u666f\uff0c\u5c08\u6ce8\u5728\u539f\u5275\u79d1\u6280\u7684\u63a2\u7d22\u4ee5\u53ca\u5728mRNA\u548cTCR-T\u8cfd\u9053\u4e0a\u7684\u6df1\u8015\u5438\u5f15\u4e86\u6211\u5011\u7684\u6ce8\u610f\u3002\u77f3\u85e5\u96c6\u5718\u662f\u4e2d\u570b\u552f\u4e00\u4e00\u5bb6\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u6279\u51c6\u7dca\u6025\u4f7f\u7528\u7684mRNA\u65b0\u51a0\u75ab\u82d7\u4f01\u696d\uff0c\u5728\u884c\u696d\u4e2d\u8eab\u7d93\u767e\u6230\uff0c\u5728\u81e8\u5e8a\u7814\u7a76\u3001\u5e02\u5834\u63a8\u5ee3\u7b49\u5404\u500b\u74b0\u7bc0\u64c1\u6709\u8c50\u5bcc\u7684\u8cc7\u6e90\u3002\u6b64\u6b21\u6295\u8cc7\u4f86\u6069\u751f\u7269\uff0c\u5e0c\u671b\u9032\u4e00\u6b65\u63a8\u9032\u4f86\u6069\u751f\u7269\u548c\u77f3\u85e5\u96c6\u5718\u5728\u4ee5mRNA\u70ba\u57fa\u790e\u7684\u591a\u7a2e\u6210\u85e5\u65b9\u5f0f\u4e0a\u5171\u540c\u63a2\u7d22\u5408\u4f5c\uff0c\u82e5\u5728\u6210\u85e5\u6027\u4e0a\u5f97\u5230\u62d3\u5c55\u53ca\u7a81\u7834\uff0c\u5c07\u4f86\u6709\u671b\u5728\u81e8\u5e8a\u548c\u5546\u696d\u5316\u7b49\u65b9\u9762\u501f\u52a9\u96d9\u65b9\u8cc7\u6e90\u5f62\u6210\u96d9\u8d0f\u7684\u5c40\u9762\u3002\u300d \u95dc\u65bc\u5ee3\u5dde\u7522\u6295 \u5ee3\u5dde\u7522\u696d\u6295\u8cc7\u63a7\u80a1\u96c6\u5718\u6709\u9650\u516c\u53f8\uff08\u7c21\u7a31\u300c\u5ee3\u5dde\u7522\u6295\u96c6\u5718\u300d\uff09 \u5ee3\u5dde\u7522\u6295\u96c6\u5718\u5805\u6301\u300c\u6295\u8cc7\u5ee3\u5dde\u3001\u6295\u8cc7\u5be6\u9ad4\u3001\u6295\u8cc7\u672a\u4f86\u300d\u7406\u5ff5\uff0c\u6a39\u7acb\u300c\u8010\u5fc3\u8cc7\u672c\u300d\u7684\u7522\u696d\u767c\u5c55\u601d\u7dad\uff0c\u7acb\u8db3\u6230\u7565\u6295\u8cc7\u767c\u5c55\u5e73\u53f0\u3001\u570b\u6709\u80a1\u6b0a\u6301\u80a1\u5e73\u53f0\u3001\u8cc7\u672c\u904b\u4f5c\u7ba1\u7406\u5e73\u53f0\u4e09\u5927\u529f\u80fd\u5b9a\u4f4d\uff0c\u7a4d\u6975\u64d4\u7576\u7522\u696d\u6295\u884c\u548c\u8cc7\u672c\u904b\u71df\u5169\u5927\u89d2\u8272\uff0c\u63a7\u53c3\u80a1\u5ee3\u6c7d\u96c6\u5718\u3001\u5ee3\u85e5\u96c6\u5718\u3001\u5ee3\u5dde\u767c\u5c55\u3001\u73e0\u6c5f\u5564\u9152\u3001\u5ee3\u5dde\u9152\u5bb6\u3001\u73e0\u6c5f\u92fc\u7434\u3001\u5dba\u5357\u63a7\u80a1\u3001\u4e2d\u570b\u96fb\u5efa\u3001\u5b5a\u80fd\u79d1\u6280\u3001\u5730\u9435\u8a2d\u8a08\u9662\u7b4910\u591a\u5bb6\u4e0a\u5e02\u516c\u53f8\u4ee5\u53ca\u8d8a\u79c0\u96c6\u5718\u3001\u570b\u65b0\u8b49\u5238\u3001\u7d2b\u5149\u96c6\u5718\u3001\u7cb5\u82af\u534a\u5c0e\u9ad4\u3001\u4e2d\u79d1\u5b87\u822a\u7b49\u4e00\u6279\u9f8d\u982d\u4f01\u696d\uff0c\u727d\u982d\u7d44\u5efa\u4e26\u904b\u4f5c\u5be6\u65bd1500\u5104\u5143\u5ee3\u5dde\u7522\u696d\u6295\u8cc7\u6bcd\u57fa\u91d1\u548c500\u5104\u5143\u5ee3\u5dde\u5275\u65b0\u6295\u8cc7\u6bcd\u57fa\u91d1\u3002\u96c6\u5718\u64c1\u67094\u5bb6\u57fa\u91d1\u7ba1\u7406\u516c\u53f8\uff0c\u6295\u8cc7\u8a2d\u7acb\u4e26\u8207\u982d\u90e8\u6a5f\u69cb\u5408\u4f5c\u8a2d\u7acb\u57fa\u91d150\u591a\u652f\uff0c\u63d0\u4f9b\u5168\u93c8\u689d\u57fa\u91d1\u6295\u8cc7\u670d\u52d9\uff0c\u5df2\u5f62\u6210\u300c\u57fa\u91d1\u7ba1\u7406+\u7522\u696d\u6295\u8cc7+\u8cc7\u672c\u904b\u71df+\u5712\u5340\u670d\u52d9+\u79d1\u6280\u670d\u52d9\u300d\u7684\u696d\u52d9\u9ad4\u7cfb\u548c\u300c\u4e0a\u5e02\u516c\u53f8\u96c6\u7fa4+\u529f\u80fd\u5e73\u53f0\u96c6\u7fa4+\u7522\u696d\u767c\u5c55\u57fa\u91d1\u7fa4+\u5275\u65b0\u50f9\u503c\u5712\u5340\u300d\u7684\u904b\u4f5c\u67b6\u69cb\uff0c\u9023\u7e8c\u4e94\u5e74\u8e8b\u8eab\u300c\u4e2d\u570b\u4f01\u696d500\u5f37\u300d\u548c\u300c\u4e2d\u570b\u670d\u52d9\u696d\u4f01\u696d500\u5f37\u300d\uff0c\u5168\u529b\u6253\u9020\u5e02\u5834\u5316\u3001\u5c08\u696d\u5316\u3001\u570b\u969b\u5316\u7684\u4e00\u6d41\u570b\u6709\u8cc7\u672c\u6295\u8cc7\u904b\u71df\u5e73\u53f0\u3002 \u95dc\u65bc\u570b\u805a\u5275\u6295 \u570b\u805a\u5275\u6295\u662f\u5ee3\u5dde\u9ad8\u65b0\u5340\u96c6\u5718\u5168\u8cc7\u79c1\u52df\u80a1\u6b0a\u57fa\u91d1\u5b50\u516c\u53f8\uff0c\u7ba1\u7406\u53ca\u53c3\u8207\u7684\u57fa\u91d1\u898f\u6a21\u903e30\u5104\u5143\u3002\u901a\u904e\u300c\u751f\u7269\u91ab\u85e5\u7522\u696d\u57fa\u91d1\u300d\u767c\u63ee\u7684\u8cc7\u91d1\u5f15\u9818\u653e\u5927\u6548\u7528\uff0c\u53c3\u8207\u8a2d\u7acb\u4e86\u300c\u4e2d\u4ee5\u4e8c\u671f\u57fa\u91d1\u300d\u3001\u300c\u5ee3\u6771\u4e2d\u91ab\u85e5\u5927\u5065\u5eb7\u57fa\u91d1\u300d\uff0c\u9678\u7e8c\u8207\u7d93\u7def\u4e2d\u570b\u3001\u677e\u79be\u8cc7\u672c\u3001\u5143\u79be\u539f\u9ede\u7b49\u77e5\u540d\u6295\u8cc7\u6a5f\u69cb\u9054\u6210\u5408\u4f5c\uff0c\u81f4\u529b\u65bc\u6210\u70ba\u7cb5\u6e2f\u6fb3\u5927\u7063\u5340\u512a\u79c0\u7684\u751f\u7269\u91ab\u85e5\u7522\u696d\u570b\u6709\u5275\u6295\u516c\u53f8\u548c\u570b\u5167\u77e5\u540d\u7684\u5e02\u5834\u5316\u6bcd\u57fa\u91d1\u7ba1\u7406\u6a5f\u69cb\u3002 \u95dc\u65bc\u77f3\u85e5\u7d0d\u5fb7 \u77f3\u85e5\u7d0d\u5fb7\u662f\u77f3\u85e5\u96c6\u5718\u548c\u7d0d\u5fb7\u8cc7\u672c\u5408\u4f5c\u7d44\u5efa\u7684\u91ab\u85e5\u6295\u8cc7\u57fa\u91d1\uff0c\u7531\u77f3\u85e5\u96c6\u5718\u4e0b\u5c6c\u7684\u4e0a\u6d77\u77f3\u8c50\u6615\u532f\u5275\u696d\u6295\u8cc7\u7ba1\u7406\u6709\u9650\u516c\u53f8\u7ba1\u7406\u3002 \u77f3\u85e5\u96c6\u5718\u662f\u4e00\u5bb6\u96c6\u5275\u65b0\u85e5\u7269\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u70ba\u4e00\u9ad4\u7684\u570b\u5bb6\u7d1a\u5275\u65b0\u578b\u4f01\u696d\u3002\u5728\u6e2f\u4e0a\u5e02\u516c\u53f8\uff0801093.HK\uff09\u8e8b\u8eab\u5343\u5104\u5e02\u503c\u4ff1\u6a02\u90e8\u3002\u77f3\u85e5\u96c6\u5718\u7522\u54c1\u92b7\u552e\u904d\u53ca\u5168\u7403100\u591a\u500b\u570b\u5bb6\u548c\u5730\u5340\uff0c\u670936\u500b\u54c1\u7a2e\u55ae\u54c1\u7a2e\u92b7\u552e\u904e\u5104\u5143\u3002\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.franchise.com.hk\/en\/%e4%be%86%e6%81%a9%e7%94%9f%e7%89%a9%e5%ae%a3%e4%bd%88%e5%ae%8c%e6%88%90%e8%b6%853%e5%84%84%e5%85%83b2%e8%bc%aa%e8%9e%8d%e8%b3%87%ef%bc%8c%e5%85%a8%e7%90%83%e9%a0%98%e8%b7%91mrna%e7%b7%a8%e7%a2%bc\/13212\" \/>\n<meta property=\"og:site_name\" content=\"\u9999\u6e2f\u7279\u8a31\u7d93\u71df\" \/>\n<meta property=\"article:published_time\" content=\"2023-06-26T16:30:00+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.franchise.com.hk\/en\/%e4%be%86%e6%81%a9%e7%94%9f%e7%89%a9%e5%ae%a3%e4%bd%88%e5%ae%8c%e6%88%90%e8%b6%853%e5%84%84%e5%85%83b2%e8%bc%aa%e8%9e%8d%e8%b3%87%ef%bc%8c%e5%85%a8%e7%90%83%e9%a0%98%e8%b7%91mrna%e7%b7%a8%e7%a2%bc\/13212#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.franchise.com.hk\/en\/%e4%be%86%e6%81%a9%e7%94%9f%e7%89%a9%e5%ae%a3%e4%bd%88%e5%ae%8c%e6%88%90%e8%b6%853%e5%84%84%e5%85%83b2%e8%bc%aa%e8%9e%8d%e8%b3%87%ef%bc%8c%e5%85%a8%e7%90%83%e9%a0%98%e8%b7%91mrna%e7%b7%a8%e7%a2%bc\/13212\"},\"author\":{\"name\":\"\",\"@id\":\"\"},\"headline\":\"\u4f86\u6069\u751f\u7269\u5ba3\u4f48\u5b8c\u6210\u8d853\u5104\u5143B2\u8f2a\u878d\u8cc7\uff0c\u5168\u7403\u9818\u8dd1mRNA\u7de8\u78bc\u7684TCR-T\u7d30\u80de\u6cbb\u7642\u5be6\u9ad4\u7624\",\"datePublished\":\"2023-06-26T16:30:00+00:00\",\"dateModified\":\"2023-06-26T16:30:00+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.franchise.com.hk\/en\/%e4%be%86%e6%81%a9%e7%94%9f%e7%89%a9%e5%ae%a3%e4%bd%88%e5%ae%8c%e6%88%90%e8%b6%853%e5%84%84%e5%85%83b2%e8%bc%aa%e8%9e%8d%e8%b3%87%ef%bc%8c%e5%85%a8%e7%90%83%e9%a0%98%e8%b7%91mrna%e7%b7%a8%e7%a2%bc\/13212\"},\"wordCount\":41,\"publisher\":{\"@id\":\"https:\/\/www.franchise.com.hk\/en#organization\"},\"articleSection\":[\"\u672a\u5206\u985e\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.franchise.com.hk\/en\/%e4%be%86%e6%81%a9%e7%94%9f%e7%89%a9%e5%ae%a3%e4%bd%88%e5%ae%8c%e6%88%90%e8%b6%853%e5%84%84%e5%85%83b2%e8%bc%aa%e8%9e%8d%e8%b3%87%ef%bc%8c%e5%85%a8%e7%90%83%e9%a0%98%e8%b7%91mrna%e7%b7%a8%e7%a2%bc\/13212\",\"url\":\"https:\/\/www.franchise.com.hk\/en\/%e4%be%86%e6%81%a9%e7%94%9f%e7%89%a9%e5%ae%a3%e4%bd%88%e5%ae%8c%e6%88%90%e8%b6%853%e5%84%84%e5%85%83b2%e8%bc%aa%e8%9e%8d%e8%b3%87%ef%bc%8c%e5%85%a8%e7%90%83%e9%a0%98%e8%b7%91mrna%e7%b7%a8%e7%a2%bc\/13212\",\"name\":\"\u4f86\u6069\u751f\u7269\u5ba3\u4f48\u5b8c\u6210\u8d853\u5104\u5143B2\u8f2a\u878d\u8cc7\uff0c\u5168\u7403\u9818\u8dd1mRNA\u7de8\u78bc\u7684TCR-T\u7d30\u80de\u6cbb\u7642\u5be6\u9ad4\u7624 - \u9999\u6e2f\u7279\u8a31\u7d93\u71df\",\"isPartOf\":{\"@id\":\"https:\/\/www.franchise.com.hk\/en#website\"},\"datePublished\":\"2023-06-26T16:30:00+00:00\",\"dateModified\":\"2023-06-26T16:30:00+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.franchise.com.hk\/en\/%e4%be%86%e6%81%a9%e7%94%9f%e7%89%a9%e5%ae%a3%e4%bd%88%e5%ae%8c%e6%88%90%e8%b6%853%e5%84%84%e5%85%83b2%e8%bc%aa%e8%9e%8d%e8%b3%87%ef%bc%8c%e5%85%a8%e7%90%83%e9%a0%98%e8%b7%91mrna%e7%b7%a8%e7%a2%bc\/13212#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.franchise.com.hk\/en\/%e4%be%86%e6%81%a9%e7%94%9f%e7%89%a9%e5%ae%a3%e4%bd%88%e5%ae%8c%e6%88%90%e8%b6%853%e5%84%84%e5%85%83b2%e8%bc%aa%e8%9e%8d%e8%b3%87%ef%bc%8c%e5%85%a8%e7%90%83%e9%a0%98%e8%b7%91mrna%e7%b7%a8%e7%a2%bc\/13212\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.franchise.com.hk\/en\/%e4%be%86%e6%81%a9%e7%94%9f%e7%89%a9%e5%ae%a3%e4%bd%88%e5%ae%8c%e6%88%90%e8%b6%853%e5%84%84%e5%85%83b2%e8%bc%aa%e8%9e%8d%e8%b3%87%ef%bc%8c%e5%85%a8%e7%90%83%e9%a0%98%e8%b7%91mrna%e7%b7%a8%e7%a2%bc\/13212#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9801\",\"item\":\"https:\/\/www.franchise.com.hk\/en\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u4f86\u6069\u751f\u7269\u5ba3\u4f48\u5b8c\u6210\u8d853\u5104\u5143B2\u8f2a\u878d\u8cc7\uff0c\u5168\u7403\u9818\u8dd1mRNA\u7de8\u78bc\u7684TCR-T\u7d30\u80de\u6cbb\u7642\u5be6\u9ad4\u7624\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.franchise.com.hk\/en#website\",\"url\":\"https:\/\/www.franchise.com.hk\/en\",\"name\":\"\u9999\u6e2f\u7279\u8a31\u7d93\u71df\",\"description\":\"\u9999\u6e2f\u7279\u8a31\u7d93\u71df | Franchise HK\",\"publisher\":{\"@id\":\"https:\/\/www.franchise.com.hk\/en#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.franchise.com.hk\/en?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.franchise.com.hk\/en#organization\",\"name\":\"\u9999\u6e2f\u7279\u8a31\u7d93\u71df\",\"url\":\"https:\/\/www.franchise.com.hk\/en\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.franchise.com.hk\/en#\/schema\/logo\/image\/\",\"url\":\"https:\/\/i0.wp.com\/www.franchise.com.hk\/wp-content\/uploads\/2022\/05\/cropped-cropped-franchise-logo-02-e1652686851566-2.png?fit=350%2C76&ssl=1\",\"contentUrl\":\"https:\/\/i0.wp.com\/www.franchise.com.hk\/wp-content\/uploads\/2022\/05\/cropped-cropped-franchise-logo-02-e1652686851566-2.png?fit=350%2C76&ssl=1\",\"width\":350,\"height\":76,\"caption\":\"\u9999\u6e2f\u7279\u8a31\u7d93\u71df\"},\"image\":{\"@id\":\"https:\/\/www.franchise.com.hk\/en#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u4f86\u6069\u751f\u7269\u5ba3\u4f48\u5b8c\u6210\u8d853\u5104\u5143B2\u8f2a\u878d\u8cc7\uff0c\u5168\u7403\u9818\u8dd1mRNA\u7de8\u78bc\u7684TCR-T\u7d30\u80de\u6cbb\u7642\u5be6\u9ad4\u7624 - \u9999\u6e2f\u7279\u8a31\u7d93\u71df","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.franchise.com.hk\/en\/%e4%be%86%e6%81%a9%e7%94%9f%e7%89%a9%e5%ae%a3%e4%bd%88%e5%ae%8c%e6%88%90%e8%b6%853%e5%84%84%e5%85%83b2%e8%bc%aa%e8%9e%8d%e8%b3%87%ef%bc%8c%e5%85%a8%e7%90%83%e9%a0%98%e8%b7%91mrna%e7%b7%a8%e7%a2%bc\/13212","og_locale":"en_US","og_type":"article","og_title":"\u4f86\u6069\u751f\u7269\u5ba3\u4f48\u5b8c\u6210\u8d853\u5104\u5143B2\u8f2a\u878d\u8cc7\uff0c\u5168\u7403\u9818\u8dd1mRNA\u7de8\u78bc\u7684TCR-T\u7d30\u80de\u6cbb\u7642\u5be6\u9ad4\u7624 - \u9999\u6e2f\u7279\u8a31\u7d93\u71df","og_description":"\u65b0\u52a0\u5761\u548c\u4e2d\u570b\u5ee3\u5dde2023\u5e746\u670827\u65e5 \/\u7f8e\u901a\u793e\/ — 2023\u5e746\u670827\u65e5\uff0c\u4f86\u6069\u751f\u7269\uff08Lion TCR\uff09\u5ba3\u4f48\u5b8c\u6210\u8d853\u5104\u5143B2\u8f2a\u878d\u8cc7\uff0c\u7531\u5ee3\u5dde\u7522\u6295\u9818\u6295\u3001\u5ee3\u5dde\u9ad8\u65b0\u5340\u96c6\u5718\u76f4\u5c6c\u4f01\u696d\u570b\u805a\u5275\u6295\u8207\u77f3\u85e5\u7d0d\u5fb7\u57fa\u91d1\u5171\u540c\u5b8c\u6210\u3002\u878d\u8cc7\u8cc7\u91d1\u5c07\u4e3b\u8981\u7528\u65bc\u652f\u6301\u4f86\u6069\u751f\u7269\u81e8\u5e8a\u8a66\u9a57\u7684\u63a8\u9032\u3001\u5ee3\u5ddeGMP\u7d30\u80de\u8eca\u9593\u7684\u5efa\u8a2d\u4ee5\u53ca\u7814\u767c\u7ba1\u7dda\u7684\u62d3\u5c55\u7b49\u3002 2023\u5e746\u670826\u65e5\uff0c\u5728\u65b0\u52a0\u5761\u885b\u751f\u90e8\u90e8\u9577\u738b\u4e59\u5eb7\u5148\u751f\u548c\u5ee3\u6771\u7701\u7701\u9577\u738b\u5049\u4e2d\u5148\u751f\u7684\u5171\u540c\u898b\u8b49\u4e0b\uff0c\u4f86\u6069\u751f\u7269\u8207\u5ee3\u5dde\u7522\u6295\u3001\u570b\u805a\u5275\u6295\u3001\u77f3\u85e5\u7d0d\u5fb7\u57fa\u91d1\u5728\u65b0\u52a0\u5761-\u5ee3\u6771\u5408\u4f5c\u7406\u4e8b\u6703\u7b2c\u5341\u4e09\u6b21\u6703\u8b70\u4e0a\u9032\u884c\u4e86\u6b64\u6b21\u878d\u8cc7\u6295\u8cc7\u5354\u8b70\u7684\u7c3d\u7d04\u3002 \u4f86\u6069\u751f\u7269\u5728\u5ee3\u6771-\u65b0\u52a0\u5761\u5408\u4f5c\u7406\u4e8b\u6703\u7b2c\u5341\u4e09\u6b21\u6703\u8b70\u4e0a\u7c3d\u7d04 \u4f86\u6069\u751f\u7269\u76ee\u524d\u5df2\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u8207\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6388\u4e88\u7684\u570b\u969b\u591a\u4e2d\u5fc3Ib\/II\u671f\u7684IND\u81e8\u5e8a\u6279\u4ef6\uff0c\u9019\u662f\u5168\u7403\u7b2c\u4e00\u500b\u7d93FDA\u6279\u51c6\uff0c\u5229\u7528TCR-T\u7d30\u80de\u6cbb\u7642\u4e59\u809d\u76f8\u95dc\u809d\u7d30\u80de\u764c\u7684\u570b\u969b\u591a\u4e2d\u5fc3\u81e8\u5e8a\u8a66\u9a57\uff0c\u76ee\u524d\u5df2\u5b8c\u6210\u591a\u4f8b\u60a3\u8005\u56de\u8f38\uff0c\u6b64TCR-T\u7d30\u80de\u7642\u6cd5\u9084\u7372\u5f97\u4e86FDA\u6388\u4e88\u7684\u5feb\u901f\u901a\u9053\u8a8d\u5b9a\uff08Fast Track\uff09\u548c\u5b64\u5152\u85e5\uff08Orphan Drug\uff09\u8cc7\u683c\u3002 \u4f86\u6069\u751f\u7269\u65bc2015\u5e74\u5f9e\u65b0\u52a0\u5761\u79d1\u6280\u7814\u7a76\u5c40\uff08A*STAR\uff09\u5b75\u5316\u800c\u51fa\uff0c\u9996\u6b3e\u7522\u54c1\u70baFirst-in-Class HBV\u7279\u7570\u6027TCR-T\u7d30\u80de\u7642\u6cd5\uff0c\u4e26\u901a\u904emRNA\u6280\u8853\u7de8\u78bcTCR\uff0c\u7528\u65bc\u6cbb\u7642\u809d\u7d30\u80de\u764c\uff0c\u5df2\u7d93\u5c55\u73fe\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u986f\u8457\u7642\u6548\u3002\u76ee\u524d\uff0c\u4f86\u6069\u751f\u7269\u5df2\u7d93\u5efa\u7acb\u4e86TCR\u767c\u73fe\u5e73\u53f0\u8207mRNA\u6280\u8853\u5e73\u53f0\uff0c\u5728\u9019\u5169\u500b\u5e73\u53f0\u57fa\u790e\u4e0a\u62d3\u5c55\u7522\u54c1\u7ba1\u7dda\uff0c\u901a\u904e\u9776\u5411\u4e0d\u540c\u9776\u9ede\u6cbb\u7642\u591a\u7a2e\u5be6\u9ad4\u7624\u3002\u4f86\u6069\u751f\u7269\u4f48\u5c40\u4e86\u5f9e\u81ea\u9ad4\u7d30\u80de\u7642\u6cd5\u5230\u73fe\u8ca8\u578b\u7642\u6cd5\u7522\u54c1\uff0c\u4ee5\u63d0\u9ad8\u60a3\u8005\u7684\u53ef\u53ca\u6027\uff0c\u70ba\u5c1a\u672a\u89e3\u6c7a\u7684\u81e8\u5e8a\u9700\u6c42\u63d0\u4f9b\u5275\u65b0\u7642\u6cd5\u3002 \u5c0d\u65bc\u672c\u8f2a\u878d\u8cc7\uff0c\u4f86\u6069\u751f\u7269\u9996\u5e2d\u57f7\u884c\u5b98\u5f6d\u66c9\u660e\u535a\u58eb\u8868\u793a\uff1a\u300c\u6b64\u6b21\u878d\u8cc7\u6210\u529f\u5c07\u52a9\u529b\u4f86\u6069\u751f\u7269\u6309\u7167\u5df2\u5efa\u7acb\u7684\u6280\u8853\u5e73\u53f0\u767c\u5c55\u6230\u7565\u5feb\u901f\u7a69\u6b65\u63a8\u9032\u7522\u54c1\u7ba1\u7dda\u3002 \u540c\u6642\u4e5f\u6709\u52a9\u65bc\u4f86\u6069\u751f\u7269\u9032\u4e00\u6b65\u4f9d\u6258\u4e2d\u65b0\u5408\u4f5c\u7684\u570b\u969b\u5e73\u53f0\u5927\u529b\u767c\u5c55\u79d1\u6280\u5275\u65b0\uff0c\u651c\u624b\u5ee3\u5dde\u7522\u6295\u3001\u5ee3\u5dde\u9ad8\u65b0\u5340\u96c6\u5718\u53ca\u77f3\u85e5\u96c6\u5718\u5728\u65b0\u52a0\u5761\u548c\u5927\u7063\u5340\u69cb\u7bc9\u570b\u969b\u751f\u7269\u79d1\u6280\u751f\u614b\u5708\uff0c\u5efa\u8a2d\u7d30\u80de\u6cbb\u7642\u9818\u57df\u7684\u793a\u7bc4\u55ae\u4f4d\uff0c\u9020\u798f\u60a3\u8005\uff0c\u56de\u994b\u793e\u6703\u3002\u300d \u4f86\u6069\u751f\u7269\u65bc2022\u5e746\u6708\u548c\u5ee3\u5dde\u5e02\u9ec3\u57d4\u5340\u653f\u5e9c\u5728\u751f\u7269\u7522\u696d\u5927\u6703\u4e0a\u6b63\u5f0f\u7c3d\u7d04\uff0c\u5c07\u4e2d\u570b\u7e3d\u90e8\u843d\u5730\u5ee3\u5dde\u4e2d\u65b0\u77e5\u8b58\u57ce\uff0c\u62d3\u5c55\u570b\u969b\u767c\u5c55\u7a7a\u9593\u3002\u5f6d\u66c9\u660e\u535a\u58eb\u9032\u4e00\u6b65\u4ecb\u7d39\uff0c\u300c\u5ee3\u5dde\u64c1\u6709\u4e2d\u570b\u9802\u5c16\u7684\u7684\u91ab\u9662\u8cc7\u6e90\uff0c\u653f\u5e9c\u4e5f\u7d66\u4e88\u91ab\u85e5\u4f01\u696d\u5f88\u591a\u653f\u7b56\u548c\u8cc7\u91d1\u652f\u6301\uff0c\u6211\u5011\u770b\u5230\u4e86\u5ee3\u5dde\u751f\u7269\u91ab\u85e5\u7522\u696d\u767c\u5c55\u7684\u6c7a\u5fc3\u548c\u53cb\u597d\u7684\u751f\u614b\u74b0\u5883\uff0c\u6240\u4ee5\u6c7a\u5b9a\u5c07\u4e2d\u570b\u7e3d\u90e8\u653e\u5728\u5ee3\u5dde\uff0c\u9019\u5c07\u662f\u96c6\u7ba1\u7dda\u7814\u767c\u3001GMP\u751f\u7522\u548c\u81e8\u5e8a\u8a3b\u518a\u65bc\u4e00\u9ad4\u7684\u7d9c\u5408\u57fa\u5730\u3002\u4e2d\u570b\u7e3d\u90e8\u7d9c\u5408\u57fa\u5730\u4f54\u5730\u7e3d\u9762\u7a4d\u8d85\u904e5000\u5e73\u7c73\uff0c\u843d\u6210\u5f8c\u5c07\u5f62\u6210\u9589\u74b0\u7684\u7b26\u5408GMP\u6a19\u6e96\u7684\u7d30\u80de\u7522\u54c1\u751f\u7522\u3001\u653e\u884c\u3001\u51b7\u93c8\u904b\u8f38\u3001\u60a3\u8005\u56de\u8f38\u7b49\u7aef\u5230\u7aef\u904b\u71df\u80fd\u529b\uff0c\u670d\u52d9\u4e2d\u570b\u60a3\u8005\u3002\u300d \u4f86\u6069\u751f\u7269\u4e2d\u570b\u7e3d\u90e8\u5ee3\u5dde\u570b\u969b\u751f\u7269\u91ab\u85e5\u5275\u65b0\u4e2d\u5fc3 \u00a0 \u4f86\u6069\u751f\u7269\u4e2d\u570b\u7e3d\u90e8\u5ee3\u5dde\u4e2d\u65b0\u667a\u6167\u5712 \u5c0d\u65bc\u672c\u6b21\u6295\u8cc7\uff0c\u9664\u4e86\u8003\u616e\u5230\u4f86\u6069\u751f\u7269\u81ea\u8eab\u5728\u6280\u8853\u65b9\u9762\u7684\u904e\u786c\u5be6\u529b\u5916\uff0c\u6295\u8cc7\u65b9\u4e5f\u5404\u6709\u8003\u91cf\u3002 \u5ee3\u5dde\u7522\u6295\u7684\u6295\u8cc7\u901a\u5e38\u6709\u4e09\u500b\u5927\u65b9\u5411\uff0c\u4e00\u662f\u6295\u8cc7\u5ee3\u5dde\uff0c\u4ee5\u6295\u4fc3\u5f15\u63a8\u52d5\u91cd\u5927\u9805\u76ee\u843d\u5730\u3002\u4e8c\u662f\u6295\u8cc7\u5be6\u9ad4\uff0c\u4ee5\u6295\u4fc3\u7522\u63a8\u9032\u7522\u696d\u8f49\u578b\u5347\u7d1a\u3002\u4e09\u662f\u6295\u8cc7\u672a\u4f86\uff0c\u4ee5\u6295\u4fc3\u5275\u6436\u4f54\u672a\u4f86\u524d\u6cbf\u9663\u5730\u3002\u5ee3\u5dde\u7522\u6295\u96c6\u5718\u7e3d\u6703\u8a08\u5e2b\u90dd\u5fc5\u50b3\u6307\u51fa\uff1a \u5ee3\u5dde\u7522\u6295\u96c6\u5718\u5728\u751f\u7269\u91ab\u85e5\u8207\u5065\u5eb7\u7522\u696d\u9818\u57df\u5df2\u7d2f\u8a08\u6295\u8cc7\u8d8514\u5104\u5143\uff0c\u767c\u63ee\u7522\u696d\u8cc7\u672c\u5f15\u9818\u4f5c\u7528\uff0c\u767c\u6398\u884c\u696d\u9f8d\u982d\u4f01\u696d\u7cbe\u6e96\u300c\u704c\u6e89\u300d\uff0c\u70ba\u5ee3\u5dde\u751f\u7269\u91ab\u85e5\u8207\u5065\u5eb7\u7522\u696d\u88dc\u93c8\u5f37\u93c8\u3002\u6b64\u6b21\u5c0d\u4f86\u6069\u751f\u7269\u7684\u6295\u8cc7\uff0c\u662f\u5ee3\u5dde\u5e02\u5728\u5275\u65b0\u5347\u7d1a\u6a5f\u9047\u4e2d\u7684\u6838\u5fc3\u9700\u6c42\uff0c\u5ee3\u5dde\u7522\u6295\u96c6\u5718\u901a\u904e\u6a39\u7acb\u300c\u6295\u8cc7\u5728\u4eca\u5929\u3001\u529f\u6548\u5728\u672a\u4f86\u300d\u7684\u767c\u5c55\u7406\u5ff5\uff0c\u4ee5\u300c\u8010\u5fc3\u8cc7\u672c\u300d\u5168\u9031\u671f\u966a\u4f34\u7684\u9577\u671f\u601d\u7dad\u70ba\u7522\u696d\u6295\u8cc7\u9805\u76ee\u63d0\u4f9b\u8cc7\u91d1\u3001\u8cc7\u6e90\u3001\u670d\u52d9\u7b49\u7684\u300c\u4e00\u652c\u5b50\u300d\u89e3\u6c7a\u65b9\u6848\uff0c\u63a8\u52d5\u5ee3\u5dde\u7522\u696d\u9ad8\u8cea\u91cf\u767c\u5c55\u3002 \u570b\u805a\u5275\u6295\u66f4\u591a\u7684\u662f\u5e0c\u671b\u548c\u4f86\u6069\u751f\u7269\u7684\u5408\u4f5c\u80fd\u5920\u5e36\u52d5\u52a0\u901f\u5ee3\u5dde\u5e02\u9ec3\u57d4\u5340\u7684\u751f\u7269\u91ab\u85e5\u767c\u5c55\u3002\u570b\u805a\u5275\u6295\u7684\u8463\u4e8b\u9577\u694a\u66e6\u8868\u793a\uff1a \u4f86\u6069\u751f\u7269\u64c1\u6709\u539f\u5275\u7684\u9776\u9ede\u6280\u8853\u53ca\u5b8c\u5584\u7684\u77e5\u8b58\u7522\u6b0a\uff0c\u5275\u65b0\u7684mRNA\u7de8\u78bc\u7684TCR-T\u5e73\u53f0\u6280\u8853\u53ef\u6301\u7e8c\u62d3\u5c55\u81f3\u591a\u7a2e\u5be6\u9ad4\u7624\uff0c\u4f86\u6069\u751f\u7269\u7684\u52a0\u5165\u5c07\u52a9\u529b\u9ec3\u57d4\u5340\u63a8\u9032\u751f\u7269\u91ab\u85e5\u7522\u696d\u767c\u5c55\uff0c\u5e36\u52d5\u9ad8\u65b0\u751f\u7269\u7522\u696d\u96c6\u7fa4\u7684\u6210\u9577\uff0c\u63d0\u5347\u5ee3\u5dde\u5e02\u4e43\u81f3\u5927\u7063\u5340\u751f\u7269\u91ab\u85e5\u5275\u65b0\u80fd\u7d1a\u3002 \u77f3\u85e5\u7d0d\u5fb7\u57fa\u91d1\u5247\u662f\u770b\u6e96\u4e86\u4f86\u6069\u751f\u7269\u5728\u884c\u696d\u5167\u9818\u5148\u7684\u6280\u8853\u5be6\u529b\u548c\u767c\u5c55\u524d\u666f\uff0c\u4ee5\u53ca\u5408\u4f5c\u53ef\u80fd\u7d66\u96d9\u65b9\u5e36\u4f86\u7684\u5de8\u5927\u597d\u8655\u3002\u77f3\u85e5\u7d0d\u5fb7\u57fa\u91d1\u7ba1\u7406\u5408\u5925\u4eba\u5b6b\u805a\u6c11\u8868\u793a\uff1a\u300c\u4f86\u6069\u751f\u7269\u7684\u539f\u5275\u79d1\u7814\u5be6\u529b\uff0c\u570b\u969b\u5316\u7684\u5718\u968a\u80cc\u666f\uff0c\u5c08\u6ce8\u5728\u539f\u5275\u79d1\u6280\u7684\u63a2\u7d22\u4ee5\u53ca\u5728mRNA\u548cTCR-T\u8cfd\u9053\u4e0a\u7684\u6df1\u8015\u5438\u5f15\u4e86\u6211\u5011\u7684\u6ce8\u610f\u3002\u77f3\u85e5\u96c6\u5718\u662f\u4e2d\u570b\u552f\u4e00\u4e00\u5bb6\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u6279\u51c6\u7dca\u6025\u4f7f\u7528\u7684mRNA\u65b0\u51a0\u75ab\u82d7\u4f01\u696d\uff0c\u5728\u884c\u696d\u4e2d\u8eab\u7d93\u767e\u6230\uff0c\u5728\u81e8\u5e8a\u7814\u7a76\u3001\u5e02\u5834\u63a8\u5ee3\u7b49\u5404\u500b\u74b0\u7bc0\u64c1\u6709\u8c50\u5bcc\u7684\u8cc7\u6e90\u3002\u6b64\u6b21\u6295\u8cc7\u4f86\u6069\u751f\u7269\uff0c\u5e0c\u671b\u9032\u4e00\u6b65\u63a8\u9032\u4f86\u6069\u751f\u7269\u548c\u77f3\u85e5\u96c6\u5718\u5728\u4ee5mRNA\u70ba\u57fa\u790e\u7684\u591a\u7a2e\u6210\u85e5\u65b9\u5f0f\u4e0a\u5171\u540c\u63a2\u7d22\u5408\u4f5c\uff0c\u82e5\u5728\u6210\u85e5\u6027\u4e0a\u5f97\u5230\u62d3\u5c55\u53ca\u7a81\u7834\uff0c\u5c07\u4f86\u6709\u671b\u5728\u81e8\u5e8a\u548c\u5546\u696d\u5316\u7b49\u65b9\u9762\u501f\u52a9\u96d9\u65b9\u8cc7\u6e90\u5f62\u6210\u96d9\u8d0f\u7684\u5c40\u9762\u3002\u300d \u95dc\u65bc\u5ee3\u5dde\u7522\u6295 \u5ee3\u5dde\u7522\u696d\u6295\u8cc7\u63a7\u80a1\u96c6\u5718\u6709\u9650\u516c\u53f8\uff08\u7c21\u7a31\u300c\u5ee3\u5dde\u7522\u6295\u96c6\u5718\u300d\uff09 \u5ee3\u5dde\u7522\u6295\u96c6\u5718\u5805\u6301\u300c\u6295\u8cc7\u5ee3\u5dde\u3001\u6295\u8cc7\u5be6\u9ad4\u3001\u6295\u8cc7\u672a\u4f86\u300d\u7406\u5ff5\uff0c\u6a39\u7acb\u300c\u8010\u5fc3\u8cc7\u672c\u300d\u7684\u7522\u696d\u767c\u5c55\u601d\u7dad\uff0c\u7acb\u8db3\u6230\u7565\u6295\u8cc7\u767c\u5c55\u5e73\u53f0\u3001\u570b\u6709\u80a1\u6b0a\u6301\u80a1\u5e73\u53f0\u3001\u8cc7\u672c\u904b\u4f5c\u7ba1\u7406\u5e73\u53f0\u4e09\u5927\u529f\u80fd\u5b9a\u4f4d\uff0c\u7a4d\u6975\u64d4\u7576\u7522\u696d\u6295\u884c\u548c\u8cc7\u672c\u904b\u71df\u5169\u5927\u89d2\u8272\uff0c\u63a7\u53c3\u80a1\u5ee3\u6c7d\u96c6\u5718\u3001\u5ee3\u85e5\u96c6\u5718\u3001\u5ee3\u5dde\u767c\u5c55\u3001\u73e0\u6c5f\u5564\u9152\u3001\u5ee3\u5dde\u9152\u5bb6\u3001\u73e0\u6c5f\u92fc\u7434\u3001\u5dba\u5357\u63a7\u80a1\u3001\u4e2d\u570b\u96fb\u5efa\u3001\u5b5a\u80fd\u79d1\u6280\u3001\u5730\u9435\u8a2d\u8a08\u9662\u7b4910\u591a\u5bb6\u4e0a\u5e02\u516c\u53f8\u4ee5\u53ca\u8d8a\u79c0\u96c6\u5718\u3001\u570b\u65b0\u8b49\u5238\u3001\u7d2b\u5149\u96c6\u5718\u3001\u7cb5\u82af\u534a\u5c0e\u9ad4\u3001\u4e2d\u79d1\u5b87\u822a\u7b49\u4e00\u6279\u9f8d\u982d\u4f01\u696d\uff0c\u727d\u982d\u7d44\u5efa\u4e26\u904b\u4f5c\u5be6\u65bd1500\u5104\u5143\u5ee3\u5dde\u7522\u696d\u6295\u8cc7\u6bcd\u57fa\u91d1\u548c500\u5104\u5143\u5ee3\u5dde\u5275\u65b0\u6295\u8cc7\u6bcd\u57fa\u91d1\u3002\u96c6\u5718\u64c1\u67094\u5bb6\u57fa\u91d1\u7ba1\u7406\u516c\u53f8\uff0c\u6295\u8cc7\u8a2d\u7acb\u4e26\u8207\u982d\u90e8\u6a5f\u69cb\u5408\u4f5c\u8a2d\u7acb\u57fa\u91d150\u591a\u652f\uff0c\u63d0\u4f9b\u5168\u93c8\u689d\u57fa\u91d1\u6295\u8cc7\u670d\u52d9\uff0c\u5df2\u5f62\u6210\u300c\u57fa\u91d1\u7ba1\u7406+\u7522\u696d\u6295\u8cc7+\u8cc7\u672c\u904b\u71df+\u5712\u5340\u670d\u52d9+\u79d1\u6280\u670d\u52d9\u300d\u7684\u696d\u52d9\u9ad4\u7cfb\u548c\u300c\u4e0a\u5e02\u516c\u53f8\u96c6\u7fa4+\u529f\u80fd\u5e73\u53f0\u96c6\u7fa4+\u7522\u696d\u767c\u5c55\u57fa\u91d1\u7fa4+\u5275\u65b0\u50f9\u503c\u5712\u5340\u300d\u7684\u904b\u4f5c\u67b6\u69cb\uff0c\u9023\u7e8c\u4e94\u5e74\u8e8b\u8eab\u300c\u4e2d\u570b\u4f01\u696d500\u5f37\u300d\u548c\u300c\u4e2d\u570b\u670d\u52d9\u696d\u4f01\u696d500\u5f37\u300d\uff0c\u5168\u529b\u6253\u9020\u5e02\u5834\u5316\u3001\u5c08\u696d\u5316\u3001\u570b\u969b\u5316\u7684\u4e00\u6d41\u570b\u6709\u8cc7\u672c\u6295\u8cc7\u904b\u71df\u5e73\u53f0\u3002 \u95dc\u65bc\u570b\u805a\u5275\u6295 \u570b\u805a\u5275\u6295\u662f\u5ee3\u5dde\u9ad8\u65b0\u5340\u96c6\u5718\u5168\u8cc7\u79c1\u52df\u80a1\u6b0a\u57fa\u91d1\u5b50\u516c\u53f8\uff0c\u7ba1\u7406\u53ca\u53c3\u8207\u7684\u57fa\u91d1\u898f\u6a21\u903e30\u5104\u5143\u3002\u901a\u904e\u300c\u751f\u7269\u91ab\u85e5\u7522\u696d\u57fa\u91d1\u300d\u767c\u63ee\u7684\u8cc7\u91d1\u5f15\u9818\u653e\u5927\u6548\u7528\uff0c\u53c3\u8207\u8a2d\u7acb\u4e86\u300c\u4e2d\u4ee5\u4e8c\u671f\u57fa\u91d1\u300d\u3001\u300c\u5ee3\u6771\u4e2d\u91ab\u85e5\u5927\u5065\u5eb7\u57fa\u91d1\u300d\uff0c\u9678\u7e8c\u8207\u7d93\u7def\u4e2d\u570b\u3001\u677e\u79be\u8cc7\u672c\u3001\u5143\u79be\u539f\u9ede\u7b49\u77e5\u540d\u6295\u8cc7\u6a5f\u69cb\u9054\u6210\u5408\u4f5c\uff0c\u81f4\u529b\u65bc\u6210\u70ba\u7cb5\u6e2f\u6fb3\u5927\u7063\u5340\u512a\u79c0\u7684\u751f\u7269\u91ab\u85e5\u7522\u696d\u570b\u6709\u5275\u6295\u516c\u53f8\u548c\u570b\u5167\u77e5\u540d\u7684\u5e02\u5834\u5316\u6bcd\u57fa\u91d1\u7ba1\u7406\u6a5f\u69cb\u3002 \u95dc\u65bc\u77f3\u85e5\u7d0d\u5fb7 \u77f3\u85e5\u7d0d\u5fb7\u662f\u77f3\u85e5\u96c6\u5718\u548c\u7d0d\u5fb7\u8cc7\u672c\u5408\u4f5c\u7d44\u5efa\u7684\u91ab\u85e5\u6295\u8cc7\u57fa\u91d1\uff0c\u7531\u77f3\u85e5\u96c6\u5718\u4e0b\u5c6c\u7684\u4e0a\u6d77\u77f3\u8c50\u6615\u532f\u5275\u696d\u6295\u8cc7\u7ba1\u7406\u6709\u9650\u516c\u53f8\u7ba1\u7406\u3002 \u77f3\u85e5\u96c6\u5718\u662f\u4e00\u5bb6\u96c6\u5275\u65b0\u85e5\u7269\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u70ba\u4e00\u9ad4\u7684\u570b\u5bb6\u7d1a\u5275\u65b0\u578b\u4f01\u696d\u3002\u5728\u6e2f\u4e0a\u5e02\u516c\u53f8\uff0801093.HK\uff09\u8e8b\u8eab\u5343\u5104\u5e02\u503c\u4ff1\u6a02\u90e8\u3002\u77f3\u85e5\u96c6\u5718\u7522\u54c1\u92b7\u552e\u904d\u53ca\u5168\u7403100\u591a\u500b\u570b\u5bb6\u548c\u5730\u5340\uff0c\u670936\u500b\u54c1\u7a2e\u55ae\u54c1\u7a2e\u92b7\u552e\u904e\u5104\u5143\u3002","og_url":"https:\/\/www.franchise.com.hk\/en\/%e4%be%86%e6%81%a9%e7%94%9f%e7%89%a9%e5%ae%a3%e4%bd%88%e5%ae%8c%e6%88%90%e8%b6%853%e5%84%84%e5%85%83b2%e8%bc%aa%e8%9e%8d%e8%b3%87%ef%bc%8c%e5%85%a8%e7%90%83%e9%a0%98%e8%b7%91mrna%e7%b7%a8%e7%a2%bc\/13212","og_site_name":"\u9999\u6e2f\u7279\u8a31\u7d93\u71df","article_published_time":"2023-06-26T16:30:00+00:00","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.franchise.com.hk\/en\/%e4%be%86%e6%81%a9%e7%94%9f%e7%89%a9%e5%ae%a3%e4%bd%88%e5%ae%8c%e6%88%90%e8%b6%853%e5%84%84%e5%85%83b2%e8%bc%aa%e8%9e%8d%e8%b3%87%ef%bc%8c%e5%85%a8%e7%90%83%e9%a0%98%e8%b7%91mrna%e7%b7%a8%e7%a2%bc\/13212#article","isPartOf":{"@id":"https:\/\/www.franchise.com.hk\/en\/%e4%be%86%e6%81%a9%e7%94%9f%e7%89%a9%e5%ae%a3%e4%bd%88%e5%ae%8c%e6%88%90%e8%b6%853%e5%84%84%e5%85%83b2%e8%bc%aa%e8%9e%8d%e8%b3%87%ef%bc%8c%e5%85%a8%e7%90%83%e9%a0%98%e8%b7%91mrna%e7%b7%a8%e7%a2%bc\/13212"},"author":{"name":"","@id":""},"headline":"\u4f86\u6069\u751f\u7269\u5ba3\u4f48\u5b8c\u6210\u8d853\u5104\u5143B2\u8f2a\u878d\u8cc7\uff0c\u5168\u7403\u9818\u8dd1mRNA\u7de8\u78bc\u7684TCR-T\u7d30\u80de\u6cbb\u7642\u5be6\u9ad4\u7624","datePublished":"2023-06-26T16:30:00+00:00","dateModified":"2023-06-26T16:30:00+00:00","mainEntityOfPage":{"@id":"https:\/\/www.franchise.com.hk\/en\/%e4%be%86%e6%81%a9%e7%94%9f%e7%89%a9%e5%ae%a3%e4%bd%88%e5%ae%8c%e6%88%90%e8%b6%853%e5%84%84%e5%85%83b2%e8%bc%aa%e8%9e%8d%e8%b3%87%ef%bc%8c%e5%85%a8%e7%90%83%e9%a0%98%e8%b7%91mrna%e7%b7%a8%e7%a2%bc\/13212"},"wordCount":41,"publisher":{"@id":"https:\/\/www.franchise.com.hk\/en#organization"},"articleSection":["\u672a\u5206\u985e"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.franchise.com.hk\/en\/%e4%be%86%e6%81%a9%e7%94%9f%e7%89%a9%e5%ae%a3%e4%bd%88%e5%ae%8c%e6%88%90%e8%b6%853%e5%84%84%e5%85%83b2%e8%bc%aa%e8%9e%8d%e8%b3%87%ef%bc%8c%e5%85%a8%e7%90%83%e9%a0%98%e8%b7%91mrna%e7%b7%a8%e7%a2%bc\/13212","url":"https:\/\/www.franchise.com.hk\/en\/%e4%be%86%e6%81%a9%e7%94%9f%e7%89%a9%e5%ae%a3%e4%bd%88%e5%ae%8c%e6%88%90%e8%b6%853%e5%84%84%e5%85%83b2%e8%bc%aa%e8%9e%8d%e8%b3%87%ef%bc%8c%e5%85%a8%e7%90%83%e9%a0%98%e8%b7%91mrna%e7%b7%a8%e7%a2%bc\/13212","name":"\u4f86\u6069\u751f\u7269\u5ba3\u4f48\u5b8c\u6210\u8d853\u5104\u5143B2\u8f2a\u878d\u8cc7\uff0c\u5168\u7403\u9818\u8dd1mRNA\u7de8\u78bc\u7684TCR-T\u7d30\u80de\u6cbb\u7642\u5be6\u9ad4\u7624 - \u9999\u6e2f\u7279\u8a31\u7d93\u71df","isPartOf":{"@id":"https:\/\/www.franchise.com.hk\/en#website"},"datePublished":"2023-06-26T16:30:00+00:00","dateModified":"2023-06-26T16:30:00+00:00","breadcrumb":{"@id":"https:\/\/www.franchise.com.hk\/en\/%e4%be%86%e6%81%a9%e7%94%9f%e7%89%a9%e5%ae%a3%e4%bd%88%e5%ae%8c%e6%88%90%e8%b6%853%e5%84%84%e5%85%83b2%e8%bc%aa%e8%9e%8d%e8%b3%87%ef%bc%8c%e5%85%a8%e7%90%83%e9%a0%98%e8%b7%91mrna%e7%b7%a8%e7%a2%bc\/13212#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.franchise.com.hk\/en\/%e4%be%86%e6%81%a9%e7%94%9f%e7%89%a9%e5%ae%a3%e4%bd%88%e5%ae%8c%e6%88%90%e8%b6%853%e5%84%84%e5%85%83b2%e8%bc%aa%e8%9e%8d%e8%b3%87%ef%bc%8c%e5%85%a8%e7%90%83%e9%a0%98%e8%b7%91mrna%e7%b7%a8%e7%a2%bc\/13212"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.franchise.com.hk\/en\/%e4%be%86%e6%81%a9%e7%94%9f%e7%89%a9%e5%ae%a3%e4%bd%88%e5%ae%8c%e6%88%90%e8%b6%853%e5%84%84%e5%85%83b2%e8%bc%aa%e8%9e%8d%e8%b3%87%ef%bc%8c%e5%85%a8%e7%90%83%e9%a0%98%e8%b7%91mrna%e7%b7%a8%e7%a2%bc\/13212#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9801","item":"https:\/\/www.franchise.com.hk\/en"},{"@type":"ListItem","position":2,"name":"\u4f86\u6069\u751f\u7269\u5ba3\u4f48\u5b8c\u6210\u8d853\u5104\u5143B2\u8f2a\u878d\u8cc7\uff0c\u5168\u7403\u9818\u8dd1mRNA\u7de8\u78bc\u7684TCR-T\u7d30\u80de\u6cbb\u7642\u5be6\u9ad4\u7624"}]},{"@type":"WebSite","@id":"https:\/\/www.franchise.com.hk\/en#website","url":"https:\/\/www.franchise.com.hk\/en","name":"\u9999\u6e2f\u7279\u8a31\u7d93\u71df","description":"\u9999\u6e2f\u7279\u8a31\u7d93\u71df | Franchise HK","publisher":{"@id":"https:\/\/www.franchise.com.hk\/en#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.franchise.com.hk\/en?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.franchise.com.hk\/en#organization","name":"\u9999\u6e2f\u7279\u8a31\u7d93\u71df","url":"https:\/\/www.franchise.com.hk\/en","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.franchise.com.hk\/en#\/schema\/logo\/image\/","url":"https:\/\/i0.wp.com\/www.franchise.com.hk\/wp-content\/uploads\/2022\/05\/cropped-cropped-franchise-logo-02-e1652686851566-2.png?fit=350%2C76&ssl=1","contentUrl":"https:\/\/i0.wp.com\/www.franchise.com.hk\/wp-content\/uploads\/2022\/05\/cropped-cropped-franchise-logo-02-e1652686851566-2.png?fit=350%2C76&ssl=1","width":350,"height":76,"caption":"\u9999\u6e2f\u7279\u8a31\u7d93\u71df"},"image":{"@id":"https:\/\/www.franchise.com.hk\/en#\/schema\/logo\/image\/"}}]}},"jetpack_featured_media_url":"https:\/\/i0.wp.com\/www.franchise.com.hk\/wp-content\/uploads\/2023\/06\/Lion_TCR_signing_Investment_Agreement_13th_Meeting_Singapore_Guangdong_Collaboration_Council-gVXi1V.jpeg?fit=600%2C400&ssl=1","_links":{"self":[{"href":"https:\/\/www.franchise.com.hk\/en\/wp-json\/wp\/v2\/posts\/13212"}],"collection":[{"href":"https:\/\/www.franchise.com.hk\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.franchise.com.hk\/en\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/www.franchise.com.hk\/en\/wp-json\/wp\/v2\/comments?post=13212"}],"version-history":[{"count":0,"href":"https:\/\/www.franchise.com.hk\/en\/wp-json\/wp\/v2\/posts\/13212\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.franchise.com.hk\/en\/wp-json\/wp\/v2\/media\/13213"}],"wp:attachment":[{"href":"https:\/\/www.franchise.com.hk\/en\/wp-json\/wp\/v2\/media?parent=13212"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.franchise.com.hk\/en\/wp-json\/wp\/v2\/categories?post=13212"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.franchise.com.hk\/en\/wp-json\/wp\/v2\/tags?post=13212"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}