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class=\"legendSpanClass\">\u4e0a\u6d77<\/span><span class=\"legendSpanClass\">2023\u5e745\u670817\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u96f2\u9802\u65b0\u8000\uff08HKEX 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Pharmaceuticals\u516c\u53f8\u958b\u767c\uff0c\u8f1d\u745e\u65bc\u53bb\u5e74\u5b8c\u6210\u4e86\u5c0dArena Pharmaceuticals\u7684\u6536\u8cfc\uff0c\u800c\u96f2\u9802\u65b0\u8000\u65bc2017\u5e74\u5f9eArena\u7372\u5f97\u4e86\u5728\u5927\u4e2d\u83ef\u5340\u548c\u97d3\u570b\u958b\u767c\u3001\u751f\u7522\u548c\u5546\u696d\u5316etrasimod\u7684\u7368\u5bb6\u6b0a\u5229\u3002<\/p>\n<p>2022\u5e7412\u6708\uff0c\u8f1d\u745e\u5ba3\u5e03\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u5df2\u53d7\u7406\u5176\u00a0etrasimod\u65b0\u85e5\u4e0a\u5e02\u8a31\u53ef\u7533\u8acb\uff08NDA\uff09\uff0c\u7528\u65bc\u6cbb\u7642\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\uff08UC\uff09\u60a3\u8005\uff0c\u9810\u8a08FDA\u5c07\u65bc2023\u5e74\u4e0b\u534a\u5e74\u4f5c\u51fa\u5be9\u6279\u3002\u9810\u8a08\u4e2d\u7684\u7f8e\u570bFDA\u6279\u51c6\u5c07\u6210\u70baetrasimod\u5728\u5168\u7403\u8303\u570d\u5167\u7372\u5f97\u7684\u9996\u6b21\u65b0\u85e5\u4e0a\u5e02\u8a31\u53ef\u6279\u51c6\u3002\u6b64\u5916\uff0c\u6b50\u6d32\u85e5\u54c1\u7ba1\u7406\u5c40\u540c\u6a23\u5df2\u53d7\u7406etrasimod\u6cbb\u7642\u76f8\u540c\u60a3\u8005\u4eba\u7fa4\u7684\u4e0a\u5e02\u8a31\u53ef\u7533\u8acb\uff0c\u9810\u8a08\u5c07\u65bc2024\u5e74\u4e0a\u534a\u5e74\u4f5c\u51fa\u5be9\u6279\u3002<\/p>\n<p>\u8f1d\u745e\u63d0\u4ea4\u7684\u65b0\u85e5\u4e0a\u5e02\u8a31\u53ef\u7533\u8acb\u57fa\u65bc\u4e4b\u524d\u516c\u5e03\u7684ELEVATE UC 3\u671f\u6ce8\u518a\u9805\u76ee\uff08ELEVATE UC 52\u548cELEVATE UC 12\uff09\u7684\u7814\u7a76\u7d50\u679c\uff0c\u8a72\u9805\u76ee\u65e8\u5728\u8a55\u50f9\u65e2\u5f80\u5c0d\u81f3\u5c11\u4e00\u7a2e\u5e38\u898f\u6cbb\u7642\u3001\u751f\u7269\u5236\u5291\u6216Janus\u6fc0\u9176\uff08JAK\uff09\u6291\u5236\u5291\u6cbb\u7642\u5931\u6557\u6216\u4e0d\u8010\u53d7\u7684\u6f70\u760d\u6027\u7d50\u8178\u708e\u60a3\u8005\uff0c\u6bcf\u65e5\u4e00\u6b21\u670d\u75282mg etrasimod\u7684\u5b89\u5168\u6027\u548c\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\u7684\u7642\u6548\u3002\u9019\u5169\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u7814\u7a76\u5747\u9054\u5230\u4e86\u6240\u6709\u4e3b\u8981\u548c\u95dc\u9375\u6b21\u8981\u7d42\u9ede\uff0c\u5b89\u5168\u6027\u7279\u5f81\u8207\u65e2\u5f80\u7814\u7a76\u4e00\u81f4\u3002\u5728ELEVATE UC 52\u7814\u7a76\u4e2d\uff0c\u7b2c12\u5468\u6642\uff0c\u63a5\u53d7etrasimod\u6cbb\u7642\u7684\u60a3\u8005\u81e8\u5e8a\u7de9\u89e3\u7387\u70ba27.0%\uff0c\u800c\u63a5\u53d7\u5b89\u6170\u5291\u5c0d\u7167\u7684\u60a3\u8005\u70ba7.4%\uff08\u76f8\u5dee19.8%\uff0cP=\u02c2.001\uff09\uff1b\u7b2c52\u5468\u6642\uff0c\u63a5\u53d7etrasimod\u6cbb\u7642\u7684\u60a3\u8005\u81e8\u5e8a\u7de9\u89e3\u7387\u70ba32.1%\uff0c\u800c\u63a5\u53d7\u5b89\u6170\u5291\u5c0d\u7167\u7684\u60a3\u8005\u70ba6.7%\uff08\u76f8\u5dee25.4%\uff0cP=\u02c2.001\uff09\u3002\u5728ELEVATE UC 12\u7814\u7a76\u4e2d\uff0c\u63a5\u53d7Etrasimod\u6cbb\u7642\u7684\u60a3\u8005\u81e8\u5e8a\u7de9\u89e3\u7387\u70ba24.8%\uff0c\u800c\u63a5\u53d7\u5b89\u6170\u5291\u6cbb\u7642\u7684\u60a3\u8005\u70ba15.2%\uff08\u76f8\u5dee9.7%\uff0cP=.0264\uff09\u3002<\/p>\n<p>\u5728ELEVATE UC 12\u7814\u7a76\u4e2d\uff0cetrasimod 2mg\u7d44\u548c\u5b89\u6170\u5291\u7d44\u767c\u751f\u6cbb\u7642\u671f\u9593\u51fa\u73fe\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TEAE\uff09\u7684\u60a3\u8005\u6bd4\u4f8b\u76f8\u4f3c\u3002\u5728ELEVATE UC 52\u7814\u7a76\u4e2d\uff0cetrasimod 2 mg\u7d44\u7684TEAE\u7684\u6bd4\u4f8b\u9ad8\u65bc\u5b89\u6170\u5291\u7d44\u3002\u5169\u9805\u7814\u7a76\u4e2detrasimod 2mg\u7d44\u8207\u5b89\u6170\u5291\u7d44\u767c\u751f\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\u7684\u60a3\u8005\u6bd4\u4f8b\u76f8\u4f3c\u3002\u5169\u9805\u7814\u7a76\u4e2d\uff0c\u6700\u9577\u6cbb\u7642\u671f\u70ba52\u5468\uff0cetrasimod 2mg\u7d44\u8207\u5b89\u6170\u5291\u7d44\u76f8\u6bd4\uff0cTEAE\u767c\u751f\u7387\u70ba3%\u53ca\u4ee5\u4e0a\u4e26\u9ad8\u65bc\u5b89\u6170\u5291\u7d44\u7684\u6700\u5e38\u898bTEAE\u70ba\u982d\u75db\u3001UC\u52a0\u91cd\u3001COVID-19\u611f\u67d3\u3001\u982d\u6688\u3001\u767c\u71b1\u3001\u95dc\u7bc0\u75db\u3001\u8179\u75db\u548c\u60e1\u5fc3\u3002\u6c92\u6709\u5831\u544a\u5fc3\u52d5\u904e\u7de9\u6216\u623f\u5ba4\u963b\u6eef\u7684\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\u3002\u6578\u64da\u8868\u660e\uff0c\u555f\u52d5etrasimod\u6cbb\u7642\u4e0d\u9700\u8981\u5fa9\u96dc\u7684\u5291\u91cf\u6ef4\u5b9a\u65b9\u6848\u3002<\/p>\n<p>\u95dc\u65bcEtrasimod<\/p>\n<p>Etrasimod\u662f\u4e00\u7a2e\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7684\u9078\u64c7\u6027\u9798\u6c28\u9187-1-\u78f7\u9178\uff08S1P\uff09\u53d7\u9ad4\u8abf\u7bc0\u5291\uff0c\u91c7\u7528\u512a\u5316\u7684\u85e5\u7406\u5b78\u8a2d\u8a08\uff0c\u8207S1P\u53d7\u9ad41\u30014\u548c5\u7d50\u5408\uff0c\u6b63\u5728\u7814\u7a76\u5c07\u5176\u7528\u65bc\u6cbb\u7642\u4e00\u7cfb\u5217\u514d\u75ab\u708e\u75c7\u6027\u75be\u75c5\u3002<\/p>\n<p>\u95dc\u65bc\u96f2\u9802\u65b0\u8000<\/p>\n<p>\u96f2\u9802\u65b0\u8000\u662f\u4e00\u5bb6\u5c08\u6ce8\u65bc\u5275\u65b0\u85e5\u548c\u75ab\u82d7\u958b\u767c\u3001\u5236\u9020\u53ca\u5546\u696d\u5316\u7684\u751f\u7269\u5236\u85e5\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u6eff\u8db3\u4e9e\u6d32\u5e02\u5834\u56b4\u91cd\u672a\u6eff\u8db3\u7684\u91ab\u7642\u9700\u6c42\u3002\u96f2\u9802\u65b0\u8000\u7684\u7ba1\u7406\u5718\u968a\u5728\u4e2d\u570b\u53ca\u5168\u7403\u9818\u5148\u5236\u85e5\u4f01\u696d\u5f9e\u4e8b\u904e\u9ad8\u8cea\u91cf\u767c\u73fe\u3001\u81e8\u5e8a\u958b\u767c\u3001\u85e5\u653f\u4e8b\u52d9\u3001\u5316\u5b78\u5236\u9020\u8207\u63a7\u5236\uff08CMC\uff09\u3001\u696d\u52d9\u767c\u5c55\u548c\u904b\u71df\uff0c\u64c1\u6709\u6df1\u539a\u7684\u5c08\u9577\u548c\u8c50\u5bcc\u7684\u7d93\u9a57\u3002\u96f2\u9802\u65b0\u8000\u5df2\u6253\u9020\u591a\u6b3e\u6709\u6f5b\u529b\u6210\u70ba\u5168\u7403\u540c\u985e\u9996\u5275\u6216\u8005\u540c\u985e\u6700\u4f73\u7684\u85e5\u7269\u7d44\u5408\u3002\u516c\u53f8\u7684\u6cbb\u7642\u9818\u57df\u5305\u62ec\u814e\u79d1\u75be\u75c5\u3001\u611f\u67d3\u6027\u548c\u50b3\u67d3\u6027\u75be\u75c5\u3001\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3002\u6709\u95dc\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\u516c\u53f8\u7db2\u7ad9\uff1a<a href=\"http:\/\/www.everestmedicines.com\/\" target=\"_blank\" rel=\"noopener\">www.everestmedicines.com<\/a>\u3002<\/p>\n<p>\u524d\u77bb\u6027\u8072\u660e\uff1a<\/p>\n<p>\u672c\u65b0\u805e\u7a3f\u6240\u767c\u5e03\u7684\u4fe1\u606f\u4e2d\u53ef\u80fd\u6703\u5305\u542b\u67d0\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\uff0c\u4e43\u57fa\u65bc\u672c\u516c\u53f8\u6216\u7ba1\u7406\u5c64\u5728\u505a\u51fa\u8868\u8ff0\u6642\u5c0d\u516c\u53f8\u696d\u52d9\u904b\u71df\u60c5\u6cc1\u53ca\u8ca1\u52d9\u72c0\u6cc1\u7684\u73fe\u6709\u770b\u6cd5\u3001\u76f8\u4fe1\u3001\u548c\u73fe\u6709\u9810\u671f\uff0c\u53ef\u80fd\u6703\u4f7f\u7528\u300c\u5c07\u300d\u3001\u300c\u9810\u671f\u300d\u3001\u300c\u9810\u6e2c\u300d\u3001\u300c\u671f\u671b\u300d\u3001\u300c\u6253\u7b97\u300d\u3001\u300c\u8a08\u5283\u300d\u3001\u300c\u76f8\u4fe1\u300d\u3001\u300c\u9810\u4f30\u300d\u3001\u300c\u78ba\u4fe1\u300d\u53ca\u5176\u4ed6\u985e\u4f3c\u8a5e\u8a9e\u9032\u884c\u8868\u8ff0\u3002\u9019\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u4e26\u975e\u5c0d\u672a\u4f86\u696d\u7e3e\u7684\u4fdd\u8b49\uff0c\u6703\u53d7\u5230\u98a8\u96aa\u3001\u4e0d\u78ba\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u97ff\uff0c\u6709\u4e9b\u4e43\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u8303\u570d\uff0c\u96e3\u4ee5\u9810\u8a08\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u5011\u7684\u696d\u52d9\u3001\u7af6\u722d\u74b0\u5883\u3001\u653f\u6cbb\u3001\u7d93\u6fdf\u3001\u6cd5\u5f8b\u548c\u793e\u6703\u60c5\u6cc1\u7684\u672a\u4f86\u8b8a\u5316\u53ca\u767c\u5c55\u7b49\u5404\u7a2e\u56e0\u7d20\u53ca\u5047\u8a2d\u7684\u5f71\u97ff\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u6703\u8207\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8cc7\u6599\u6709\u8f03\u5927\u5dee\u5225\u3002\u672c\u516c\u53f8\u53ca\u5404\u9644\u5c6c\u516c\u53f8\u3001\u5404\u4f4d\u8463\u4e8b\u3001\u7ba1\u7406\u4eba\u54e1\u3001\u9867\u554f\u53ca\u4ee3\u7406\u672a\u66fe\u4e14\u6982\u4e0d\u627f\u64d4\u66f4\u65b0\u8a72\u7a3f\u4ef6\u6240\u8f09\u524d\u77bb\u6027\u8868\u8ff0\u4ee5\u53cd\u6620\u5728\u672c\u65b0\u805e\u7a3f\u767c\u5e03\u65e5\u5f8c\u6700\u65b0\u4fe1\u606f\u3001\u672a\u4f86\u9805\u76ee\u6216\u60c5\u5f62\u7684\u4efb\u4f55\u7fa9\u52d9\uff0c\u9664\u975e\u6cd5\u5f8b\u8981\u6c42\u3002<\/p>","protected":false},"excerpt":{"rendered":"<p>\u4e0a\u6d772023\u5e745\u670817\u65e5 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2022\u5e7412\u6708\uff0c\u8f1d\u745e\u5ba3\u5e03\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u5df2\u53d7\u7406\u5176\u00a0etrasimod\u65b0\u85e5\u4e0a\u5e02\u8a31\u53ef\u7533\u8acb\uff08NDA\uff09\uff0c\u7528\u65bc\u6cbb\u7642\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\uff08UC\uff09\u60a3\u8005\uff0c\u9810\u8a08FDA\u5c07\u65bc2023\u5e74\u4e0b\u534a\u5e74\u4f5c\u51fa\u5be9\u6279\u3002\u9810\u8a08\u4e2d\u7684\u7f8e\u570bFDA\u6279\u51c6\u5c07\u6210\u70baetrasimod\u5728\u5168\u7403\u8303\u570d\u5167\u7372\u5f97\u7684\u9996\u6b21\u65b0\u85e5\u4e0a\u5e02\u8a31\u53ef\u6279\u51c6\u3002\u6b64\u5916\uff0c\u6b50\u6d32\u85e5\u54c1\u7ba1\u7406\u5c40\u540c\u6a23\u5df2\u53d7\u7406etrasimod\u6cbb\u7642\u76f8\u540c\u60a3\u8005\u4eba\u7fa4\u7684\u4e0a\u5e02\u8a31\u53ef\u7533\u8acb\uff0c\u9810\u8a08\u5c07\u65bc2024\u5e74\u4e0a\u534a\u5e74\u4f5c\u51fa\u5be9\u6279\u3002 \u8f1d\u745e\u63d0\u4ea4\u7684\u65b0\u85e5\u4e0a\u5e02\u8a31\u53ef\u7533\u8acb\u57fa\u65bc\u4e4b\u524d\u516c\u5e03\u7684ELEVATE UC 3\u671f\u6ce8\u518a\u9805\u76ee\uff08ELEVATE UC 52\u548cELEVATE UC 12\uff09\u7684\u7814\u7a76\u7d50\u679c\uff0c\u8a72\u9805\u76ee\u65e8\u5728\u8a55\u50f9\u65e2\u5f80\u5c0d\u81f3\u5c11\u4e00\u7a2e\u5e38\u898f\u6cbb\u7642\u3001\u751f\u7269\u5236\u5291\u6216Janus\u6fc0\u9176\uff08JAK\uff09\u6291\u5236\u5291\u6cbb\u7642\u5931\u6557\u6216\u4e0d\u8010\u53d7\u7684\u6f70\u760d\u6027\u7d50\u8178\u708e\u60a3\u8005\uff0c\u6bcf\u65e5\u4e00\u6b21\u670d\u75282mg etrasimod\u7684\u5b89\u5168\u6027\u548c\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\u7684\u7642\u6548\u3002\u9019\u5169\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u7814\u7a76\u5747\u9054\u5230\u4e86\u6240\u6709\u4e3b\u8981\u548c\u95dc\u9375\u6b21\u8981\u7d42\u9ede\uff0c\u5b89\u5168\u6027\u7279\u5f81\u8207\u65e2\u5f80\u7814\u7a76\u4e00\u81f4\u3002\u5728ELEVATE UC 52\u7814\u7a76\u4e2d\uff0c\u7b2c12\u5468\u6642\uff0c\u63a5\u53d7etrasimod\u6cbb\u7642\u7684\u60a3\u8005\u81e8\u5e8a\u7de9\u89e3\u7387\u70ba27.0%\uff0c\u800c\u63a5\u53d7\u5b89\u6170\u5291\u5c0d\u7167\u7684\u60a3\u8005\u70ba7.4%\uff08\u76f8\u5dee19.8%\uff0cP=\u02c2.001\uff09\uff1b\u7b2c52\u5468\u6642\uff0c\u63a5\u53d7etrasimod\u6cbb\u7642\u7684\u60a3\u8005\u81e8\u5e8a\u7de9\u89e3\u7387\u70ba32.1%\uff0c\u800c\u63a5\u53d7\u5b89\u6170\u5291\u5c0d\u7167\u7684\u60a3\u8005\u70ba6.7%\uff08\u76f8\u5dee25.4%\uff0cP=\u02c2.001\uff09\u3002\u5728ELEVATE UC 12\u7814\u7a76\u4e2d\uff0c\u63a5\u53d7Etrasimod\u6cbb\u7642\u7684\u60a3\u8005\u81e8\u5e8a\u7de9\u89e3\u7387\u70ba24.8%\uff0c\u800c\u63a5\u53d7\u5b89\u6170\u5291\u6cbb\u7642\u7684\u60a3\u8005\u70ba15.2%\uff08\u76f8\u5dee9.7%\uff0cP=.0264\uff09\u3002 \u5728ELEVATE UC 12\u7814\u7a76\u4e2d\uff0cetrasimod 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