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\u6301\u7e8c\u9ad8\u6c34\u6e96\u7814\u767c<\/p>\n<p>\u548c\u8b7d\u91ab\u85e5\u76ee\u524d\u5df2\u958b\u767c\u4e86\u5305\u62ec15\u500b\u9805\u76ee\u7814\u767c\u7ba1\u7dda\uff0c\u9032\u5165\u81e8\u5e8a\u968e\u6bb5\u7684\u5df2\u90547\u500b\uff0c\u5176\u4e2dPimicotinib\u3001Irpagratinib\u3001Fexagratinib\u4e09\u689d\u7ba1\u7dda\u9032\u5165\u81e8\u5e8a\u6982\u5ff5\u9a57\u8b49\u968e\u6bb5\u4e26\u5747\u57282022\u5e74\u5e95\u53d6\u5f97\u4e86\u521d\u6b65\u7a4d\u6975\u7d50\u679c\u3002<\/p>\n<p>\u300cPimicotinib\u662f\u548c\u8b7d\u7533\u8acbIND\u7684\u7b2c\u4e00\u500b\u816b\u7624\u514d\u75ab\u5c0f\u5206\u5b50\uff0c\u816b\u7624\u514d\u75ab\u6bd4\u7cbe\u6e96\u9776\u5411\u6709\u512a\u52e2\u7684\u5730\u65b9\u5c31\u662f\u5b83\u7684\u5ee3\u8b5c\u9069\u7528\u6027\u3002Pimicotinib\u8abf\u7bc0\u5de8\u566c\u7d30\u80de\uff0c\u800c\u5de8\u566c\u7d30\u80de\u662f\u514d\u75ab\u7cfb\u7d71\u4e00\u985e\u4e3b\u8981\u7d30\u80de\uff0c\u5728\u4eba\u9ad4\u591a\u500b\u5668\u5b98\u5747\u6709\u5206\u4f48\uff0c\u8ddf\u591a\u7a2e\u75be\u75c5\u76f8\u95dc\u3002\u6240\u4ee5Pimicotinib\u7684\u6f5b\u5728\u9069\u61c9\u75c7\u4e5f\u975e\u5e38\u591a\u300d\uff0c\u9673\u535a\u58eb\u81ea\u8c6a\u5730\u8aaa\uff0c\u300c2022\u5e74\uff0cPimicotinib\u5728\u7b2c\u4e00\u500b\u9069\u61c9\u75c7\u8171\u9798\u9245\u7d30\u80de\u7624\u7684\u81e8\u5e8aIb\u671f\u5be6\u9a57\u4e2d\u5c55\u73fe\u51fa\u512a\u7570\u7684\u7642\u6548\uff0868% ORR\uff09\u548c\u5b89\u5168\u6027\uff0c\u9a57\u8b49\u4e86\u6210\u70ba\u5168\u7403Best-In-Class\u7684\u6f5b\u529b\uff0c\u4e26\u7372\u5f97\u4e2d\u570b\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u8b49\u548c\u4e09\u671f\u8a66\u9a57\u6279\u51c6\uff0c\u5c07\u572823\u5e74\u4e0a\u534a\u5e74\u555f\u52d5\u8a72\u9069\u61c9\u75c7\u7684\u81e8\u5e8aIII\u671f\uff0c\u6210\u70ba\u6211\u5011\u516c\u53f8\u7b2c\u4e00\u500b\u9032\u5165\u8a3b\u518a\u6027\u81e8\u5e8a\u8a66\u9a57\u7684\u85e5\u7269\u3002\u6211\u5011\u4e5f\u5728\u8207FDA\u548cEMA\u9032\u884c\u4ea4\u6d41\uff0c\u5e0c\u671b\u540c\u6b65\u5c07\u8a3b\u518a\u6027\u81e8\u5e8a\u63a8\u9032\u5230\u7f8e\u570b\u548c\u6b50\u6d32\uff0c\u771f\u6b63\u5e36\u4f86\u5168\u7403\u50f9\u503c\u300d\u3002Pimicotinib\u662f\u548c\u8b7d\u91ab\u85e5\u7368\u7acb\u81ea\u4e3b\u7814\u767c\u7684\u4e00\u6b3e\u5168\u65b0\u7684\u53e3\u670d\u3001\u9ad8\u9078\u64c7\u6027\u3001\u9ad8\u6d3b\u6027CSF-1R\u5c0f\u5206\u5b50\u6291\u5236\u5291\uff0c\u4e5f\u662f\u4e2d\u570b\u516c\u53f8\u958b\u767c\u7684\u9996\u6b3e\u5df2\u9032\u5165\u81e8\u5e8a\u8a66\u9a57\u7684\u9ad8\u9078\u64c7\u6027CSF-1R\u6291\u5236\u5291\u3002\u8171\u9798\u9245\u7d30\u80de\u7624\u6bcf\u5e74\u5168\u4e16\u754c\u6709\u6578\u5341\u842c\u65b0\u767c\u75c5\u4eba\uff0c\u5176\u4e2d\u5728\u4e2d\u570b\u7d04\u67096-7\u842c\uff0c\u4e14\u7121\u4efb\u4f55\u7372\u6279\u6cbb\u7642\u85e5\u7269\u3002\u9664\u8171\u9798\u9245\u7d30\u80de\u7624\u5916\uff0c\u548c\u8b7d\u9084\u5728\u540c\u6b65\u5927\u529b\u63a8\u9032Pimicotinib\u5728\u591a\u7a2e\u816b\u7624\u548c\u975e\u816b\u7624\u9069\u61c9\u75c7\u4e2d\u7684\u81e8\u5e8a\uff0c\u529b\u722d\u76e1\u5feb\u6700\u5927\u7a0b\u5ea6\u767c\u63ee\u8a72\u9805\u76ee\u7684\u6cbb\u7642\u548c\u5546\u696d\u5316\u6f5b\u529b\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u300c2022\u5e74\uff0c\u6211\u5011\u7684FGFR4\u6291\u5236\u5291Irpagratinib\u5728\u91dd\u5c0d\u665a\u671f\u809d\u764c\u7684\u81e8\u5e8a1b\u671f\u8a66\u9a57\u4e2d\u5c55\u73fe\u51fa22%-33%\uff08BID\u5291\u91cf\u7d44\uff09\u7684ORR, \u4e0d\u4f46\u662f\u540c\u985e\u6700\u512a\uff0c\u751a\u81f3\u80fd\u6210\u70ba\u540c\u985e\u9996\u5275\u3002\u56e0\u70ba\u6b64\u524d\u5168\u7403\u7bc4\u570d\u5167\u7684\u4e09\u56db\u6b3eFGFR4\u6291\u5236\u5291\u7684\u81e8\u5e8a\u65e9\u671fORR\u50c5\u6709\u767e\u5206\u4e4b\u5341\u5e7e\uff0c\u90fd\u9084\u672a\u80fd\u63a8\u9032\u5230\u8a3b\u518a\u6027\u81e8\u5e8a\u8a66\u9a57\uff0c\u300d\u9673\u535a\u58eb\u8868\u793a\uff0c\u300c\u6211\u5011\u6703\u572823\u5e74\u5b8c\u6210\u62d3\u5c55\u7814\u7a76\uff0c\u78ba\u5b9a\u6700\u597d\u7684\u7d66\u85e5\u5291\u91cf\u548c\u65b9\u5f0f\uff0c\u722d\u53d6\u76e1\u5feb\u9032\u5165\u8a3b\u518a\u6027\u81e8\u5e8a\u3002\u300d\u540c\u6642\uff0c\u548c\u8b7d\u91ab\u85e5\u9084\u5728\u5c0d\u4e2d\u570b\u5167\u5730FGF19\u904e\u8868\u9054\u7684\u665a\u671fHCC\u60a3\u8005\u9032\u884cIrpagratinib\u806f\u5408\u6297PD-L1\u6297\u9ad4\u963f\u66ff\u5229\u73e0\u55ae\u6297\u7684\u81e8\u5e8aII\u671f\u8a66\u9a57\uff0c\u8a72\u8a66\u9a57\u76ee\u6a19\u662f\u885d\u64ca\u4e00\u7dda\u7642\u6cd5\uff0c\u4ee5\u671f\u7372\u5f97\u66f4\u5927\u7684\u5e02\u5834\u6a5f\u6703\u3002<\/p>\n<p>2022\u5e7412\u67088\u65e5\uff0c 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\u6b64\u5916\uff0c\u300c2022\u5e74\uff0c\u6211\u5011\u7684FGFR4\u6291\u5236\u5291Irpagratinib\u5728\u91dd\u5c0d\u665a\u671f\u809d\u764c\u7684\u81e8\u5e8a1b\u671f\u8a66\u9a57\u4e2d\u5c55\u73fe\u51fa22%-33%\uff08BID\u5291\u91cf\u7d44\uff09\u7684ORR, 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2022\u5e7412\u67088\u65e5\uff0c \u548c\u8b7d\u6cdbFGFR\u6291\u5236\u5291Fexagratinib\u5c0d\u5c3f\u8def\u4e0a\u76ae\u764c\u60a3\u8005\u7684\u521d\u6b65II\u671f\u5b89\u5168\u6027\u53ca\u7642\u6548\u7d50\u679c\u516c\u4f48\u3002\u300cFexagratinib\u5728\u8a72\u8a66\u9a57\u521d\u671f\u5c55\u73fe\u51fa30.8%\u7684ORR\uff0c\u8207\u5168\u7403\u5728\u5c3f\u8def\u4e0a\u76ae\u764c\u552f\u4e00\u5df2\u7d93\u7372\u6279\u7684FGFR\u85e5\u7269erdafitinib\u76f8\u7576\u3002\u300d\u9673\u535a\u58eb\u4ecb\u7d39\uff0c\u300c\u5c3f\u8def\u4e0a\u76ae\u764c\u6211\u5011\u5c07\u7e7c\u7e8c\u529b\u63a8Fexagratinib\u7684\u958b\u767c\u3002FGFR\u4f5c\u70ba\u6cdb\u816b\u7624\u9776\u9ede\uff0c \u9084\u8207\u591a\u500b\u9069\u61c9\u75c7\u5bc6\u5207\u76f8\u95dc\uff0c\u5305\u62ec\u80ba\u764c\u3001\u81bd\u7ba1\u764c\u3001\u80c3\u764c\u3001\u4e73\u817a\u764c\u7b49\u3002\u548c\u8b7d\u5728\u9019\u500b\u9818\u57df\u6253\u9020\u4e86Fexagratinib, 061, 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\u300cPimicotinib\u662f\u548c\u8b7d\u7533\u8acbIND\u7684\u7b2c\u4e00\u500b\u816b\u7624\u514d\u75ab\u5c0f\u5206\u5b50\uff0c\u816b\u7624\u514d\u75ab\u6bd4\u7cbe\u6e96\u9776\u5411\u6709\u512a\u52e2\u7684\u5730\u65b9\u5c31\u662f\u5b83\u7684\u5ee3\u8b5c\u9069\u7528\u6027\u3002Pimicotinib\u8abf\u7bc0\u5de8\u566c\u7d30\u80de\uff0c\u800c\u5de8\u566c\u7d30\u80de\u662f\u514d\u75ab\u7cfb\u7d71\u4e00\u985e\u4e3b\u8981\u7d30\u80de\uff0c\u5728\u4eba\u9ad4\u591a\u500b\u5668\u5b98\u5747\u6709\u5206\u4f48\uff0c\u8ddf\u591a\u7a2e\u75be\u75c5\u76f8\u95dc\u3002\u6240\u4ee5Pimicotinib\u7684\u6f5b\u5728\u9069\u61c9\u75c7\u4e5f\u975e\u5e38\u591a\u300d\uff0c\u9673\u535a\u58eb\u81ea\u8c6a\u5730\u8aaa\uff0c\u300c2022\u5e74\uff0cPimicotinib\u5728\u7b2c\u4e00\u500b\u9069\u61c9\u75c7\u8171\u9798\u9245\u7d30\u80de\u7624\u7684\u81e8\u5e8aIb\u671f\u5be6\u9a57\u4e2d\u5c55\u73fe\u51fa\u512a\u7570\u7684\u7642\u6548\uff0868% ORR\uff09\u548c\u5b89\u5168\u6027\uff0c\u9a57\u8b49\u4e86\u6210\u70ba\u5168\u7403Best-In-Class\u7684\u6f5b\u529b\uff0c\u4e26\u7372\u5f97\u4e2d\u570b\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u8b49\u548c\u4e09\u671f\u8a66\u9a57\u6279\u51c6\uff0c\u5c07\u572823\u5e74\u4e0a\u534a\u5e74\u555f\u52d5\u8a72\u9069\u61c9\u75c7\u7684\u81e8\u5e8aIII\u671f\uff0c\u6210\u70ba\u6211\u5011\u516c\u53f8\u7b2c\u4e00\u500b\u9032\u5165\u8a3b\u518a\u6027\u81e8\u5e8a\u8a66\u9a57\u7684\u85e5\u7269\u3002\u6211\u5011\u4e5f\u5728\u8207FDA\u548cEMA\u9032\u884c\u4ea4\u6d41\uff0c\u5e0c\u671b\u540c\u6b65\u5c07\u8a3b\u518a\u6027\u81e8\u5e8a\u63a8\u9032\u5230\u7f8e\u570b\u548c\u6b50\u6d32\uff0c\u771f\u6b63\u5e36\u4f86\u5168\u7403\u50f9\u503c\u300d\u3002Pimicotinib\u662f\u548c\u8b7d\u91ab\u85e5\u7368\u7acb\u81ea\u4e3b\u7814\u767c\u7684\u4e00\u6b3e\u5168\u65b0\u7684\u53e3\u670d\u3001\u9ad8\u9078\u64c7\u6027\u3001\u9ad8\u6d3b\u6027CSF-1R\u5c0f\u5206\u5b50\u6291\u5236\u5291\uff0c\u4e5f\u662f\u4e2d\u570b\u516c\u53f8\u958b\u767c\u7684\u9996\u6b3e\u5df2\u9032\u5165\u81e8\u5e8a\u8a66\u9a57\u7684\u9ad8\u9078\u64c7\u6027CSF-1R\u6291\u5236\u5291\u3002\u8171\u9798\u9245\u7d30\u80de\u7624\u6bcf\u5e74\u5168\u4e16\u754c\u6709\u6578\u5341\u842c\u65b0\u767c\u75c5\u4eba\uff0c\u5176\u4e2d\u5728\u4e2d\u570b\u7d04\u67096-7\u842c\uff0c\u4e14\u7121\u4efb\u4f55\u7372\u6279\u6cbb\u7642\u85e5\u7269\u3002\u9664\u8171\u9798\u9245\u7d30\u80de\u7624\u5916\uff0c\u548c\u8b7d\u9084\u5728\u540c\u6b65\u5927\u529b\u63a8\u9032Pimicotinib\u5728\u591a\u7a2e\u816b\u7624\u548c\u975e\u816b\u7624\u9069\u61c9\u75c7\u4e2d\u7684\u81e8\u5e8a\uff0c\u529b\u722d\u76e1\u5feb\u6700\u5927\u7a0b\u5ea6\u767c\u63ee\u8a72\u9805\u76ee\u7684\u6cbb\u7642\u548c\u5546\u696d\u5316\u6f5b\u529b\u3002 \u6b64\u5916\uff0c\u300c2022\u5e74\uff0c\u6211\u5011\u7684FGFR4\u6291\u5236\u5291Irpagratinib\u5728\u91dd\u5c0d\u665a\u671f\u809d\u764c\u7684\u81e8\u5e8a1b\u671f\u8a66\u9a57\u4e2d\u5c55\u73fe\u51fa22%-33%\uff08BID\u5291\u91cf\u7d44\uff09\u7684ORR, \u4e0d\u4f46\u662f\u540c\u985e\u6700\u512a\uff0c\u751a\u81f3\u80fd\u6210\u70ba\u540c\u985e\u9996\u5275\u3002\u56e0\u70ba\u6b64\u524d\u5168\u7403\u7bc4\u570d\u5167\u7684\u4e09\u56db\u6b3eFGFR4\u6291\u5236\u5291\u7684\u81e8\u5e8a\u65e9\u671fORR\u50c5\u6709\u767e\u5206\u4e4b\u5341\u5e7e\uff0c\u90fd\u9084\u672a\u80fd\u63a8\u9032\u5230\u8a3b\u518a\u6027\u81e8\u5e8a\u8a66\u9a57\uff0c\u300d\u9673\u535a\u58eb\u8868\u793a\uff0c\u300c\u6211\u5011\u6703\u572823\u5e74\u5b8c\u6210\u62d3\u5c55\u7814\u7a76\uff0c\u78ba\u5b9a\u6700\u597d\u7684\u7d66\u85e5\u5291\u91cf\u548c\u65b9\u5f0f\uff0c\u722d\u53d6\u76e1\u5feb\u9032\u5165\u8a3b\u518a\u6027\u81e8\u5e8a\u3002\u300d\u540c\u6642\uff0c\u548c\u8b7d\u91ab\u85e5\u9084\u5728\u5c0d\u4e2d\u570b\u5167\u5730FGF19\u904e\u8868\u9054\u7684\u665a\u671fHCC\u60a3\u8005\u9032\u884cIrpagratinib\u806f\u5408\u6297PD-L1\u6297\u9ad4\u963f\u66ff\u5229\u73e0\u55ae\u6297\u7684\u81e8\u5e8aII\u671f\u8a66\u9a57\uff0c\u8a72\u8a66\u9a57\u76ee\u6a19\u662f\u885d\u64ca\u4e00\u7dda\u7642\u6cd5\uff0c\u4ee5\u671f\u7372\u5f97\u66f4\u5927\u7684\u5e02\u5834\u6a5f\u6703\u3002 2022\u5e7412\u67088\u65e5\uff0c \u548c\u8b7d\u6cdbFGFR\u6291\u5236\u5291Fexagratinib\u5c0d\u5c3f\u8def\u4e0a\u76ae\u764c\u60a3\u8005\u7684\u521d\u6b65II\u671f\u5b89\u5168\u6027\u53ca\u7642\u6548\u7d50\u679c\u516c\u4f48\u3002\u300cFexagratinib\u5728\u8a72\u8a66\u9a57\u521d\u671f\u5c55\u73fe\u51fa30.8%\u7684ORR\uff0c\u8207\u5168\u7403\u5728\u5c3f\u8def\u4e0a\u76ae\u764c\u552f\u4e00\u5df2\u7d93\u7372\u6279\u7684FGFR\u85e5\u7269erdafitinib\u76f8\u7576\u3002\u300d\u9673\u535a\u58eb\u4ecb\u7d39\uff0c\u300c\u5c3f\u8def\u4e0a\u76ae\u764c\u6211\u5011\u5c07\u7e7c\u7e8c\u529b\u63a8Fexagratinib\u7684\u958b\u767c\u3002FGFR\u4f5c\u70ba\u6cdb\u816b\u7624\u9776\u9ede\uff0c \u9084\u8207\u591a\u500b\u9069\u61c9\u75c7\u5bc6\u5207\u76f8\u95dc\uff0c\u5305\u62ec\u80ba\u764c\u3001\u81bd\u7ba1\u764c\u3001\u80c3\u764c\u3001\u4e73\u817a\u764c\u7b49\u3002\u548c\u8b7d\u5728\u9019\u500b\u9818\u57df\u6253\u9020\u4e86Fexagratinib, 061, 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\u6b64\u5916\uff0c\u300c2022\u5e74\uff0c\u6211\u5011\u7684FGFR4\u6291\u5236\u5291Irpagratinib\u5728\u91dd\u5c0d\u665a\u671f\u809d\u764c\u7684\u81e8\u5e8a1b\u671f\u8a66\u9a57\u4e2d\u5c55\u73fe\u51fa22%-33%\uff08BID\u5291\u91cf\u7d44\uff09\u7684ORR, 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